MCID: HMN010
MIFTS: 68

Hemangioma malady

Summaries for Hemangioma

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A cell type benign neoplasm that has physical basis in endothelial cells that line blood vessels and is characterised by increased number of normal or abnormal vessels filled with blood.

MalaCards: Hemangioma is related to cavernous hemangioma and capillary hemangioma. An important gene associated with Hemangioma is KDR (kinase insert domain receptor (a type III receptor tyrosine kinase)), and among its related pathways are PI3K-Akt signaling pathway and Angiogenesis. The drugs interferon alfa-2a and interferon alfa-2b and the compounds vegf and tyrosine have been mentioned in the context of this disorder. Affiliated tissues include endothelial, liver and lung, and related mouse phenotypes are cardiovascular system and nervous system.

Wikipedia:63 A hemangioma is a benign and usually self-involuting tumor (swelling or growth) of the endothelial cells... more...

Aliases & Classifications for Hemangioma

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 39NCIt
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Aliases & Descriptions:

hemangioma 8 42 10 44 60


Related Diseases for Hemangioma

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17GeneCards, 18GeneDecks
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Diseases in the Hemangioma family:

Acquired Hemangioma Familial Hemangioma

Diseases related to Hemangioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 502)
idRelated DiseaseScoreTop Affiliating Genes
1cavernous hemangioma31.6KRIT1
2capillary hemangioma31.5SLC2A1
3sclerosing hemangioma31.2SFTPB
4hemangioma of lung31.0SFTPB
5hepatitis31.0KRIT1, PRKG1, IFNA2
6klippel-trenaunay syndrome30.6KRIT1, FLT4
7von hippel-lindau disease30.4VEGFA
8retinal disease30.4VEGFA, KDR, SLC2A1, TEK
9angiosarcoma30.3KDR, MUC1, FLT4, ACTC1, TEK, PECAM1
10cerebral cavernous malformation30.3PECAM1, KRIT1, KDR
11hemangioma, capillary infantile30.2FLT4, KDR
12sarcoma30.2ACTC1, KDR, MUC1, PRKG1, FLT4, AR
13hepatocellular carcinoma30.2TEK, KRIT1, SLC2A1, KDR, VEGFA, NKX2-1
14adenoma30.2FLT4, PRKG1, NKX2-1, SYP, MUC1, SLC2A1
15lymphangioma30.2FLT4, PROX1, ACTC1, PECAM1, LYVE1
16meningioma30.1SLC2A1, MUC1, SYP
17deficiency anemia30.1IFNA2
18adenocarcinoma30.1SFTPB, AR, FLT4, NKX2-1, SYP, SYNM
19arteriovenous malformation30.1SLC2A1, PECAM1
20melanoma30.0IFNA2, FLT4, NKX2-1, VEGFA, KDR, ACTC1
21pyogenic granuloma30.0LYVE1, PECAM1, TEK, ACTC1, SLC2A1, FLT4
22hemangioblastoma30.0SLC2A1, KDR, MUC1, VEGFA, SYP
23fibrosarcoma30.0ACTC1
24kaposi's sarcoma29.9TEK, KDR, VEGFA, FLT4, IFNA2, PECAM1
25lung adenocarcinoma29.9SFTPB, FLT4, NKX2-1, VEGFA, MUC1, KDR
26neuroblastoma29.9SYP
27angiomyolipoma29.9ACTC1
28breast cancer29.8AR, FLT4, PROX1, VEGFA, MUC1, KDR
29papillary carcinoma29.8NKX2-1, SYP, MUC1, SLC2A1, ACTC1
30thyroid cancer29.8NKX2-1, KDR, SLC2A1, TEK
31renal clear cell carcinoma29.8VEGFA, MUC1, KDR, SLC2A1
32hemangioendothelioma29.8IFNA2, FLT4
33glomus tumor29.8ACTC1, SYP
34hemangioma, capillary infantile, somatic29.8FLT4, KDR
35medulloblastoma29.8ACTC1, SYNM, SYP
36papilloma29.8IFNA2, FLT4
37non-small cell lung carcinoma29.6FLT4, NKX2-1, SYP, VEGFA, KDR, SLC2A1
38leukemia29.6IFNA2, FLT4, PRKG1, KDR, KRIT1, TEK
39ovarian cancer29.6FLT4, NKX2-1, VEGFA, MUC1, KDR, SLC2A1
40endometrial carcinoma29.6FLT4, NKX2-1, VEGFA, SLC2A1, TEK
41astrocytoma29.6SYP, VEGFA, KDR, SLC2A1, TEK
42lung small cell carcinoma29.6FLT4, NKX2-1, SYP, MUC1, KDR
43colon cancer29.6FLT4, VEGFA, KDR, KRIT1
44lung cancer29.6VEGFA, SYP, NKX2-1, PRKG1, SFTPB
45colorectal cancer29.6KDR, VEGFA, NKX2-1, FLT4, IFNA2
46neuroendocrine carcinoma29.6MUC1, SYNM, SYP, NKX2-1
47lymphedema29.6LYVE1, PROX1, FLT4
48papillary adenocarcinoma29.6SLC2A1, MUC1, NKX2-1
49inflammatory breast carcinoma29.6PROX1, TEK, LYVE1
50leiomyoma29.6ACTC1, PRKG1

Graphical network of the top 20 diseases related to Hemangioma:



Diseases related to hemangioma

Clinical Features for Hemangioma

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Drugs & Therapeutics for Hemangioma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Hemangioma

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Anatomical Context for Hemangioma

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30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Hemangioma:

32
Endothelial, Liver, Lung, Bone, Skin, Breast, Colon, Thyroid, Testis, Kidney, Spinal cord, Spleen, Tongue, Small intestine, Brain, Cervix, Retina, Heart, Lymph node, Uterus, Adrenal gland, B cells, Placenta, Eye, Trachea, Pituitary, Myeloid, Thymus, Testes, Skeletal muscle, Fetal liver, Appendix, Ovary, Fetal lung, Tonsil, Prostate, Adipocyte, Salivary gland, Pancreas, Monocytes, Smooth muscle, Thalamus

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Hemangioma:
id TissueAnatomical CompartmentCell Relevance
1 HeartCardinal VeinsVenous Endothelial Cells Affected by disease

Animal Models for Hemangioma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Hemangioma:

36 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538511.3LYVE1, AR, FLT4, PROX1, PRKG1, NKX2-1
2MP:000363111.2AR, NETO2, PROX1, PRKG1, NKX2-1, SYP
3MP:001076811.1PRKG1, PROX1, FLT4, AR, SFTPB, NKX2-1
4MP:000538411.1AR, PROX1, PRKG1, NKX2-1, VEGFA, KDR
5MP:000287311.1AR, FLT4, PROX1, PRKG1, SYP, VEGFA
6MP:000538111.1AR, FLT4, PROX1, PRKG1, NKX2-1, VEGFA
7MP:000537610.9AR, PROX1, ACTC1, PECAM1
8MP:000539710.8PROX1, PRKG1, VEGFA, KDR, TEK, PECAM1
9MP:000537010.8AR, FLT4, PROX1, VEGFA, MUC1, KDR
10MP:000536910.8PRKG1, KDR, ACTC1
11MP:000301210.7FLT4, NKX2-1, SYP, VEGFA, MUC1, KDR
12MP:000538010.5AR, FLT4, VEGFA, KDR, SLC2A1, KRIT1

Publications for Hemangioma

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50PubMed
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Articles related to Hemangioma:

(show top 50)    (show all 1972)
idTitleAuthorsYear
1
Segmental ulcerated perineal hemangioma of infancy: a complex case of PELVIS syndrome successfully treated using a multidisciplinary approach. (23278237)
2013
2
Cavernous sinus but not intrasellar cavernous hemangioma. (24005750)
2013
3
Pericytes from infantile hemangioma display proangiogenic properties and dysregulated angiopoietin-1. (23288163)
2013
4
Approach to the patient with an infantile hemangioma. (23557656)
2013
5
A retrospective study of propranolol therapy in 109 infants with infantile hemangioma. (23252446)
2013
6
A hepatic sclerosed hemangioma with significant morphological change over a period of 10 years: a case report. (23714181)
2013
7
Unusual features in an adult pancreatic hemangioma: CT and MRI demonstration. (24043972)
2013
8
A rare tumor of the lung: pulmonary sclerosing hemangioma (pneumocytoma). (23290153)
2013
9
Pulmonary angiomatosis and hemangioma in common dolphins (Delphinus delphis) stranded in Canary Islands. (22467071)
2012
10
Epithelioid hemangioma (angiolymphoid hyperplasia with eosinophilia) in the oral mucosa. (22945722)
2012
11
Solitary cavernous hemangioma of the small intestine as the cause of long-standing iron deficiency anemia. (22875598)
2012
12
Lessons from a liver hemangioma registry: subtype classification. (22244411)
2012
13
Adult primary retroperitoneal cavernous hemangioma: a case report. (23216883)
2012
14
Thrombosed cavernous hemangioma arising in cervical ectopic thymus tissue: a case report. (23248863)
2012
15
Giant tentorial cavernous hemangioma: case report and review of literature. (21820241)
2011
16
Radiology case of the month: 11-year-old girl with intramuscular hemangioma. Intramuscular hemangioma within the right soleus muscle. (21954659)
2011
17
Extradural cavernous hemangioma of thoracic spine. (21877050)
2011
18
Intravenous lobular capillary hemangioma. (20494549)
2010
19
Multilevel ulnar neuropathy caused by multiple intraneural hemangiomas. (19918768)
2010
20
Capillary hemangioma or pyogenic granuloma: A diagnostic dilemma. (22114397)
2010
21
Cavernous hemangioma replacing the septal leaflet of the tricuspid valve. (20529155)
2010
22
Case of a malignant melanoma developing on an underlying cavernous hemangioma. (19250327)
2009
23
Adult Kasabach-Merritt Syndrome due to Hepatic Giant Hemangioma. (21103246)
2009
24
Placental anomalies in children with infantile hemangioma. (17845154)
2007
25
Expression of E-cadherin, beta-catenin and p120ctn in the pulmonary sclerosing hemangioma. (17383052)
2007
26
PHACE syndrome with intracerebral hemangiomas, heterotopia, and endocrine dysfunction. (17560503)
2007
27
Venous hemangioma arising from the diaphragm: a case report of computed tomography and magnetic resonance imaging findings. (16915071)
2006
28
Adult giant hemangioma of the larynx: a case report. (16934420)
2006
29
Obstructive jaundice in a child with pancreatic hemangioma. (16047179)
2005
30
The relationship between the expression of HIF-1alpha and the angiogenesis in infancy hemangioma]. (16011198)
2005
31
Maxillary sinus cavernous hemangioma: a rare entity. (15141765)
2004
32
Genomic imprinting of IGF2 is maintained in infantile hemangioma despite its high level of expression. (15706404)
2004
33
Cervicofacial hemangioma and its association with PHACE syndrome. (12748574)
2003
34
Treatment of retinal capillary hemangioma. (12359597)
2002
35
Subglottic hemangioma treated with interferon alpha 2A. (11894636)
2002
36
Cavernous hemangioma of the sphenoid sinus: case report and review of the literature. (11311917)
2001
37
Intramuscular hemangioma with phleboliths or choristoma? (11732048)
2001
38
Ossified intramuscular hemangioma: multimodality imaging findings. (11682298)
2001
39
Solitary retinal capillary hemangioma: hereditary (von Hippel-Lindau disease) or nonhereditary? (11176984)
2001
40
Large cavernous hemangioma of the kidney presenting as a solid renal mass. (12452609)
2001
41
Ruthenium-106 brachytherapy for peripheral retinal capillary hemangioma. (9709747)
1998
42
Radiologic case study. Intramuscular hemangioma. (8905869)
1996
43
Interferon for hemangiomas of infancy]. (8070722)
1994
44
Intramuscular hemangioma of the head and neck. (8437870)
1993
45
Treatment of a massive orbital-capillary hemangioma with interferon alfa-2b: short-term results. (1417530)
1992
46
Blue rubber bleb nevus syndrome with oral hemangiomas. (1994329)
1991
47
Giant hemangioma of liver with bleeding tendency: report of 2 cases. (4067463)
1985
48
Parapharyngeal combined neurilemmoma and hemangioma. (6512450)
1984
49
Ossifying capillary hemangioma of the maxillary and ethmoid sinuses - a case report. (6801269)
1981
50
Sclerosing hemangioma of the lung. (5676973)
1968

Genetic Variations for Hemangioma

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Expression for genes affiliated with Hemangioma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hemangioma

Search GEO for disease gene expression data for Hemangioma.

Pathways for genes affiliated with Hemangioma

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Sources:
29KEGG, 4Cell Signaling Technology, 52R&D Systems, 49PharmGKB, 55SinoBiological, 51QIAGEN, 12EMD Millipore, 37NCBI BioSystems Database, 53Reactome
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Compounds for genes affiliated with Hemangioma

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44Novoseek, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 49PharmGKB, 2BitterDB
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Compounds related to Hemangioma according to GeneCards/GeneDecks:

(show top 50)    (show all 73)
idCompoundScoreTop Affiliating Genes
1vegf4411.6PROX1, FLT4, AR, IFNA2, SFTPB, PRKG1
2tyrosine4411.6FLT4, IFNA2, SFTPB, PECAM1, KDR, MUC1
3paraffin4411.6MUC1, SYP, LYVE1, PECAM1, TEK, SFTPB
4retinoic acid44 2412.4SFTPB, ACTC1, KDR, MUC1, SYP, NKX2-1
5matrigel4411.3MUC1, PECAM1, TEK, ACTC1, KDR, VEGFA
6cysteine4411.3PECAM1, SLC2A1, KDR, MUC1, SYP, IFNA2
7ribonucleic acid4411.3MUC1, PECAM1, TEK, ACTC1, SFTPB, IFNA2
8thymidine44 2412.3TEK, PECAM1, LYVE1, IFNA2, PRKG1, MUC1
9progesterone44 59 28 11 2415.3LYVE1, MUC1, SYP, NKX2-1, AR, IFNA2
10serine4411.3PECAM1, KRIT1, SYP, NKX2-1, PRKG1, SFTPB
11dexamethasone44 49 28 1114.3NKX2-1, KDR, SLC2A1, KRIT1, VEGFA, AR
12nitric oxide44 11 2413.2KRIT1, SFTPB, MUC1, KDR, PRKG1, SYP
13oxygen44 2412.2MUC1, PECAM1, SLC2A1, PRKG1, FLT4, TEK
14actinomycin d4411.2KRIT1, PECAM1, MUC1, VEGFA, SLC2A1, AR
15formaldehyde44 2412.2NKX2-1, SYP, KRIT1, ACTC1, PECAM1, MUC1
16agar4411.2KDR, IFNA2, AR, MUC1, PECAM1, SLC2A1
17tamoxifen44 49 28 1114.2IFNA2, AR, MUC1, KDR, KRIT1, VEGFA
18testosterone44 59 11 2414.2KRIT1, ACTC1, SYP, PRKG1, AR, LYVE1
19rapamycin4411.1SLC2A1, KDR, PECAM1, VEGFA, AR, FLT4
20hematoxylin4411.1PECAM1, NKX2-1, ACTC1, SYP, MUC1
21genistein44 28 59 2 11 2416.1SYP, AR, VEGFA, SLC2A1, KRIT1, KDR
222,4-dinitrophenol4411.1NKX2-1, SLC2A1, SFTPB, AR
23mucicarmine4411.1ACTC1, NKX2-1, MUC1, SYP
24threonine4411.1PECAM1, TEK, KRIT1, PRKG1, MUC1, NKX2-1
25gold4411.1IFNA2, MUC1, KRIT1, SYP, SFTPB
26cisplatin44 49 59 1114.1SYP, SLC2A1, KDR, VEGFA, IFNA2, MUC1
27b 7234411.1ACTC1, SYP, MUC1, NKX2-1
28azd 21714411.0FLT4, VEGFA, KDR
29chloramphenicol44 2 1113.0MUC1, PRKG1, SFTPB, AR, LYVE1
30zd64744411.0KDR, VEGFA, FLT4
31cyclic amp44 2412.0SYP, KRIT1, MUC1, TEK, SFTPB, NKX2-1
32axitinib44 59 1113.0FLT4, VEGFA, KDR
33s 1004411.0ACTC1, SYP, MUC1
34progestin4411.0AR, VEGFA, MUC1, KDR
35su54164411.0VEGFA, KDR, FLT4
36reticulin4411.0SYP, ACTC1, MUC1
375fluorouracil4411.0SLC2A1, MUC1, IFNA2
38geldanamycin44 49 59 1114.0KRIT1, KDR, VEGFA, AR
39Regorafenib1110.9FLT4, KDR, TEK
40sunitinib44 49 1112.9KDR, VEGFA, FLT4
41vegfc2810.8FLT4, KDR
42ly2940024410.8FLT4, AR, VEGFA, KDR, SLC2A1
43vegfe2810.8KDR, FLT4
44glucose4410.8SLC2A1, ACTC1, MUC1, IFNA2, LYVE1, PRKG1
45procymidone4410.7LYVE1, AR
46linuron4410.7LYVE1, AR
47polyglycine4410.7LYVE1, AR
48leucovorin44 49 1112.6KDR, VEGFA, IFNA2
49glycogen44 2411.6SLC2A1, PRKG1, ACTC1, SYP, MUC1
50steroid4410.5IFNA2, SYP, AR, NKX2-1, ACTC1, LYVE1

GO Terms for genes affiliated with Hemangioma

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16Gene Ontology
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Cellular components related to Hemangioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell-cell junctionGO:00591110.6TEK, KRIT1, SLC2A1
2extracellular regionGO:00557610.5TEK, SFTPA1, IFNA2, FLT4, VEGFA, MUC1

Biological processes related to Hemangioma according to GeneCards/GeneDecks:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of endothelial cell migrationGO:01059511.1TEK, KDR, VEGFA, PROX1, FLT4
2positive regulation of endothelial cell proliferationGO:00193811.1FLT4, PROX1, VEGFA, KDR, TEK
3positive regulation of cell proliferationGO:00828411.0AR, FLT4, PROX1, VEGFA, KDR
4positive regulation of protein phosphorylationGO:00193411.0TEK, KDR, VEGFA, FLT4
5positive regulation of focal adhesion assemblyGO:05189411.0TEK, KDR, VEGFA
6negative regulation of endothelial cell apoptotic processGO:200035211.0TEK, KRIT1, KDR
7cellular response to vascular endothelial growth factor stimulusGO:03592411.0FLT4, VEGFA, KDR
8vascular endothelial growth factor receptor signaling pathwayGO:04801011.0KDR, VEGFA, FLT4
9blood coagulationGO:00759611.0IFNA2, PRKG1, VEGFA, TEK, PECAM1
10angiogenesisGO:00152511.0TEK, KRIT1, KDR, VEGFA
11peptidyl-tyrosine phosphorylationGO:01810810.9TEK, KDR, FLT4
12transmembrane receptor protein tyrosine kinase signaling pathwayGO:00716910.9FLT4, KDR, TEK
13positive regulation of MAPK cascadeGO:04341010.9AR, FLT4, KDR
14skeletal muscle thin filament assemblyGO:03024010.9PROX1, ACTC1
15positive regulation of intracellular protein kinase cascadeGO:01074010.8TEK, VEGFA
16lymph vessel developmentGO:00194510.8KDR, FLT4
17positive regulation of protein kinase C signaling cascadeGO:09003710.8VEGFA, FLT4
18positive regulation of positive chemotaxisGO:05092710.8VEGFA, KDR
19lung developmentGO:03032410.7VEGFA, NKX2-1, PROX1
20surfactant homeostasisGO:04312910.7VEGFA, KDR
21lymphangiogenesisGO:00194610.6FLT4, PROX1
22positive regulation of angiogenesisGO:04576610.6VEGFA, KDR, TEK
23mammary gland alveolus developmentGO:06074910.6VEGFA, AR
24positive regulation of ERK1 and ERK2 cascadeGO:07037410.5TEK, KDR, FLT4
25cell migration involved in sprouting angiogenesisGO:00204210.3KDR, VEGFA

Molecular functions related to Hemangioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551511.0PECAM1, IFNA2, AR, FLT4, PROX1, PRKG1
2vascular endothelial growth factor-activated receptor activityGO:00502110.6KDR, FLT4
3transmembrane receptor protein tyrosine kinase activityGO:00471410.3TEK, KDR, FLT4

Products for genes affiliated with Hemangioma

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  • Antibodies
  • Proteins
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Sources for Hemangioma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet