MCID: HMN010
MIFTS: 71

Hemangioma malady

Genetic diseases, Rare diseases, Cancer diseases categories
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Summaries for Hemangioma

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Disease Ontology:8 A cell type benign neoplasm that has physical basis in endothelial cells that line blood vessels and is characterised by increased number of normal or abnormal vessels filled with blood.

MalaCards based summary: Hemangioma is related to cavernous hemangioma and capillary hemangioma. An important gene associated with Hemangioma is KDR (kinase insert domain receptor (a type III receptor tyrosine kinase)), and among its related pathways are Signaling events mediated by TCPTP and Akt Signaling Pathway. The drugs interferon alfa-2a and interferon alfa-2b and the compounds vegfe and vegfc have been mentioned in the context of this disorder. Affiliated tissues include endothelial, liver and lung, and related mouse phenotypes are no phenotypic analysis and liver/biliary system.

Wikipedia:65 A hemangioma is a benign and usually self-involuting tumor (swelling or growth) of the endothelial cells... more...

Aliases & Classifications for Hemangioma

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Hemangioma, Aliases & Descriptions:

Name: Hemangioma 30 8 42 10 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases, Cancer diseases


Related Diseases for Hemangioma

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Diseases in the Hemangioma family:

Acquired Hemangioma Hemangioma, Hereditary
Familial Hemangioma

Diseases related to Hemangioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 534)
idRelated DiseaseScoreTop Affiliating Genes
1cavernous hemangioma32.4KRIT1
2capillary hemangioma32.4SLC2A1
3sclerosing hemangioma32.2SFTPB
4hemangioendothelioma31.2FLT4, IFNA2
5klippel-trenaunay syndrome31.1KRIT1, FLT4
6hemangioma, capillary infantile31.0KDR, FLT4
7epithelioid hemangioendothelioma31.0IFNA2, FLT4
8pyogenic granuloma31.0TEK, FLT4, ACTC1, SLC2A1
9cerebral cavernous malformation31.0KRIT1, KDR
10hepatitis30.9PRKG1, KRIT1, IFNA2
11lymphangioma30.9ACTC1, FLT4
12meningioma30.6MUC1, SLC2A1
13paraganglioma30.5ACTC1
14teratoma30.5ACTC1, NKX2-1
15papilloma30.4FLT4, IFNA2
16angiosarcoma30.4ACTC1, KDR, MUC1, TEK, FLT4
17hypothyroidism30.4IFNA2, NKX2-1
18rhabdoid tumor30.3ACTC1, MUC1
19giant cell tumor30.3ACTC1, MUC1
20hemangioblastoma30.2MUC1, KDR, VEGFA, SLC2A1
21kaposi's sarcoma30.0TEK, IFNA2, VEGFA, KDR, FLT4
22papillary carcinoma30.0MUC1, NKX2-1, SLC2A1, ACTC1
23papillary adenocarcinoma29.9MUC1, SLC2A1, NKX2-1
24astrocytoma29.8TEK, KDR, SLC2A1, VEGFA
25melanoma29.8KDR, IFNA2, ACTC1, VEGFA, NKX2-1, TEK
26lung cancer29.7MUC1, VEGFA, NKX2-1
27colorectal cancer29.7VEGFA, KDR, FLT4, IFNA2, NKX2-1
28neuroendocrine carcinoma29.6NKX2-1, MUC1
29adenoma29.6SLC2A1, PRKG1, FLT4, NKX2-1, MUC1, ACTC1
30non-small cell lung carcinoma29.5TEK, KDR, FLT4, NKX2-1, SLC2A1, VEGFA
31sarcoma29.4TEK, KDR, ACTC1, AR, FLT4, PRKG1
32leukemia29.0KDR, TEK, KRIT1, FLT4, PRKG1, IFNA2
33adenocarcinoma28.9SFTPB, MUC1, KDR, VEGFA, SLC2A1, TEK
34breast cancer28.9FLT4, AR, SLC2A1, KRIT1, TEK, KDR
35intramuscular hemangioma10.7
36giant hemangioma10.7
37pulmonary sclerosing hemangioma10.7
38retinitis10.7
39endotheliitis10.6
40venous hemangioma10.6
41choroiditis10.5
42adenosarcoma10.5ACTC1
43hydrocele10.5FLT4
44weber syndrome10.5
45histiocytoid hemangioma10.5
46phace syndrome10.5
47thrombocytopenia10.5
48glomeruloid hemangioma10.5
49sturge-weber syndrome10.4
50rapidly involuting congenital hemangioma10.4

Graphical network of the top 20 diseases related to Hemangioma:



Diseases related to hemangioma

Symptoms for Hemangioma

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Drugs & Therapeutics for Hemangioma

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Genetic Tests for Hemangioma

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Anatomical Context for Hemangioma

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MalaCards organs/tissues related to Hemangioma:

32
Endothelial, Liver, Lung, Bone, Skin, Breast, Colon, Thyroid, Spinal cord, Kidney, Testis, Spleen, Tongue, Lymph node, Brain, Small intestine, Cervix, Retina, Heart, Uterus, Adrenal gland, B cells, Eye, Thymus, Placenta, Testes, Myeloid, Trachea, Pituitary, Smooth muscle, Skeletal muscle, Adipocyte, Pancreas, Salivary gland, Ovary, Prostate, Tonsil, Monocytes, Thalamus, Medulla oblongata, Fetal liver, Fetal lung, Appendix

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Hemangioma:
id TissueAnatomical CompartmentCell Relevance
1 HeartCardinal VeinsVenous Endothelial Cells Affected by disease

Animal Models for Hemangioma or affiliated genes

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Publications for Hemangioma

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Articles related to Hemangioma:

(show top 50)    (show all 2051)
idTitleAuthorsYear
1
Time-resolved imaging of contrast kinetics imaging showing a vertebral hemangioma in CNS superficial siderosis. (25234095)
2014
2
Cavernous hemangioma of the third ventricle: a case report and review of the literature. (25069472)
2014
3
Three-dimensional stereophotogrammetry: a novel method in volumetric measurement of infantile hemangioma. (24106998)
2014
4
Chemoresponsive liver hemangioma in a patient with metastatic malignant teratoma. (25168798)
2014
5
Mediastinal hemangioma: Masquerading as pleural effusion. (24347874)
2013
6
Dubin-Johnson syndrome with multiple liver cavernous hemangiomas: report of a familial case. (24228133)
2013
7
Segmental ulcerated perineal hemangioma of infancy: a complex case of PELVIS syndrome successfully treated using a multidisciplinary approach. (23278237)
2013
8
Congenital intraosseous cavernous hemangioma of the skull: an unusual case. (25060919)
2013
9
Malignant Differential Diagnosis in Children Referred for Infantile Hemangioma. (23903077)
2013
10
Cavernous sinus but not intrasellar cavernous hemangioma. (24005750)
2013
11
Nasal lobular capillary hemangioma. (24228209)
2013
12
Rapidly Involuting Congenital Hemangioma Associated with Profound, Transient Thrombocytopenia. (22937785)
2012
13
Pharmacologic therapies for infantile hemangioma: is there a rational basis? (22456390)
2012
14
Editorial comment to a case of large bladder hemangioma successfully treated with endoscopic yttrium aluminium garnet laser irradiation. (22211454)
2012
15
Nasal cavity lobular capillary hemangioma due to insect sting. (22921301)
2012
16
Myometrial cavernous hemangioma with pulmonary thromboembolism in a post-partum woman: a case report and review of the literature. (23176111)
2012
17
Hepatic angiomyolipoma with a giant hemangioma. (22041879)
2011
18
Lobular capillary hemangioma in the soft tissue of the finger: sonographic findings. (20428860)
2010
19
Soluble receptors for vascular endothelial growth factor (sVEGFR1/sVEGFR2) in infantile hemangioma. (20854187)
2010
20
Cavernous hemangioma presenting as a giant cervical mass: a case report. (20066626)
2010
21
Cavernous sinus cavernous hemangioma largely extending into the sella turcica and mimicking pituitary adenoma: case report. (20448429)
2010
22
A giant scrotal cavernous hemangioma extending to the penis and perineum: a case report. (19767262)
2009
23
Spinal radiosurgical treatment for thoracic epidural cavernous hemangioma presenting as radiculomyelopathy: technical case report. (19487867)
2009
24
Use of thalidomide to diminish growth velocity in a life-threatening congenital intracranial hemangioma. (18671617)
2008
25
Adult onset flatfoot associated with an intramuscular hemangioma of the posterior tibialis muscle. (19292229)
2008
26
Electroconvulsive therapy in a patient with a cavernous hemangioma. (18562947)
2008
27
Atrial hemangioma: a rare cause of hydrops fetalis and intrauterine fetal death. (16621228)
2007
28
The expression and role of glucose transporter-1 in infantile hemangioma]. (17554865)
2007
29
Management of urethral hemangiomas associated with Klippel-Trenaunay-Weber syndrome by endoscopic sclerotherapy. (17645615)
2007
30
Intramuscular cavernous hemangioma arising from masseter muscle: a diagnostic dilemma (2006: 12b). (17225132)
2007
31
Venous hemangioma arising from the diaphragm: a case report of computed tomography and magnetic resonance imaging findings. (16915071)
2006
32
Spontaneous hemopneumothorax as a result of venous hemangioma: a unique case? (16572882)
2006
33
Spindle cell hemangioma and epithelioid hemangioendothelioma arising in an area of lymphedema. (16778491)
2006
34
Ahmed glaucoma valve implant for childhood glaucoma in Sturge-Weber syndrome with choroidal hemangioma. (17214399)
2006
35
Intravenous pyogenic granuloma or intravenous lobular capillary hemangioma. (15565332)
2005
36
Surgical treatment of a huge cavernous hemangioma surrounding the right coronary artery. (15854977)
2005
37
Hemoperitoneum from a spontaneous rupture of a giant hemangioma of the liver: report of a case. (12768374)
2003
38
Unilateral progressive multiple sclerosing hemangioma in a young female successfully treated by pneumonectomy: report of a case. (12222919)
2002
39
Clusterin/apoJ expression during the development of hemangioma. (10872662)
2000
40
Posterior mediastinal capillary hemangioma with extradural extension resembling neuroblastoma. (10398787)
1999
41
Pedunculated giant hemangioma of liver. (9167384)
1997
42
Successful treatment of infantile hemangiomas with interferon-alpha-2b. (9201147)
1997
43
Capillary hemangioma--report of a case. (9522754)
1996
44
Aneurysm of the transverse cervical artery occurring in association with a cavernous hemangioma as a complication of Klippel-TrAcnaunay syndrome: report of a case. (8640026)
1995
45
A benign neuroendocrine tumor of the lung: study on the origin of the so-called sclerosing hemangioma of the lung]. (8082241)
1994
46
Gastric hemangioma associated with phleboliths. (3972216)
1985
47
Histiocytoid hemangioma with features of angiolymphoid hyperplasia and Kaposi's sarcoma. A study by light microscopy, electron microscopy, and immunologic techniques. (6230021)
1983
48
Histiocytoid hemangioma of the skin and scapula. A case report with electron microscopy and immunohistochemistry. (6403216)
1983
49
Radionuclide and CT diagnosis: cavernous hemangioma of liver. (6250385)
1980
50
Non-neoplastic sclerotic pulmonary lesion (sclerosing hemangioma). Report of a case. (4331028)
1971

Variations for Hemangioma

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Expression for genes affiliated with Hemangioma

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Expression patterns in normal tissues for genes affiliated with Hemangioma

Search GEO for disease gene expression data for Hemangioma.

Pathways for genes affiliated with Hemangioma

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Pathways related to Hemangioma according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9KDR, VEGFA
29.7FLT4, KDR, TEK
39.7TEK, KDR, FLT4
49.7TEK, KDR, FLT4
5
Show member pathways
9.6FLT4, KDR, VEGFA
6
Show member pathways
9.6FLT4, KDR, VEGFA
7
Show member pathways
9.6FLT4, KDR, VEGFA
8
Show member pathways
VEGFR1 specific signals37
9.6FLT4, KDR, VEGFA
9
Show member pathways
Angiogenesis37
9.6TEK, VEGFA, KDR
109.5VEGFA, KDR, SLC2A1
119.4SLC2A1, VEGFA, TEK
12
Show member pathways
9.3TEK, KDR, FLT4, SLC2A1
13
Show member pathways
9.2TEK, KDR, FLT4, IFNA2
14
Show member pathways
9.0TEK, KDR, FLT4, AR
158.9IFNA2, FLT4, KDR, VEGFA, TEK
16
Show member pathways
8.9TEK, VEGFA, KDR, FLT4, IFNA2
17
Show member pathways
8.9KRIT1, FLT4, KDR, VEGFA, TEK
18
Show member pathways
8.8PRKG1, FLT4, KDR, TEK
19
Show member pathways
8.6TEK, VEGFA, PRKG1, IFNA2

Compounds for genes affiliated with Hemangioma

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Compounds related to Hemangioma according to GeneCards/GeneDecks:

(show top 50)    (show all 90)
idCompoundScoreTop Affiliating Genes
1vegfe2810.3FLT4, KDR
2vegfc2810.2KDR, FLT4
3azd 21714410.1FLT4, VEGFA, KDR
4zd64744410.0VEGFA, KDR, FLT4
5axitinib61 44 1112.0VEGFA, FLT4, KDR
6su54164410.0KDR, VEGFA, FLT4
7sunitinib44 50 1112.0KDR, VEGFA, FLT4
8vandetanib50 1111.0KDR, VEGFA, TEK
9ptk787449.9VEGFA, KDR
10sorafenib44 50 1111.8FLT4, VEGFA, KDR
11mucicarmine449.8ACTC1, NKX2-1, MUC1
12regorafenib50 1110.7VEGFA, FLT4, TEK, KDR
13b 723449.7NKX2-1, MUC1, ACTC1
14leucovorin44 50 1111.7IFNA2, VEGFA, KDR
15su6668449.6VEGFA, KDR
16infliximab44 50 1111.5IFNA2, VEGFA, TEK
17trastuzumab44 50 1111.4KDR, MUC1, VEGFA
182,4-dinitrophenol449.3SFTPB, AR, SLC2A1, NKX2-1
19hematoxylin449.3ACTC1, NKX2-1, MUC1
20formaldehyde44 2410.3KRIT1, MUC1, ACTC1, NKX2-1
21geldanamycin44 50 61 1112.2KRIT1, KDR, VEGFA, AR
22gold449.1MUC1, SFTPB, IFNA2, KRIT1
23progestin449.1VEGFA, MUC1, AR, KDR
24rapamycin449.0AR, FLT4, KDR, VEGFA, SLC2A1
25ly294002449.0KDR, FLT4, SLC2A1, VEGFA, AR
265fluorouracil449.0KDR, IFNA2, SLC2A1, MUC1, VEGFA
27cisplatin44 50 61 1111.8MUC1, KDR, VEGFA, SLC2A1, IFNA2
28ascorbic acid44 249.8SFTPB, IFNA2, SLC2A1, AR
29cyclic amp44 249.8KRIT1, NKX2-1, SFTPB, MUC1, TEK
30genistein44 28 61 2 24 1113.8VEGFA, AR, SLC2A1, KRIT1, KDR
31progesterone44 28 61 24 1112.7MUC1, ACTC1, AR, IFNA2, SFTPB
32agar448.7KDR, MUC1, IFNA2, AR, SLC2A1
33ribonucleic acid448.4NKX2-1, ACTC1, TEK, SFTPB, MUC1, IFNA2
34chloramphenicol44 2 50 1111.4AR, PRKG1, MUC1, SFTPB
35matrigel448.3MUC1, ACTC1, AR, FLT4, TEK, VEGFA
36tamoxifen44 50 28 1111.3AR, MUC1, KRIT1, IFNA2, KDR, VEGFA
37actinomycin d448.3VEGFA, SFTPB, MUC1, KRIT1, SLC2A1, AR
38thymidine44 249.3SFTPB, KDR, TEK, PRKG1, IFNA2, MUC1
39cysteine448.2KRIT1, IFNA2, KDR, SFTPB, TEK, SLC2A1
40nitric oxide44 24 1110.1KRIT1, SFTPB, PRKG1, TEK, KDR, MUC1
41threonine448.1KRIT1, SFTPB, TEK, MUC1, NKX2-1, PRKG1
42retinoic acid44 249.0KDR, FLT4, MUC1, IFNA2, ACTC1, SFTPB
43testosterone44 61 24 1110.9PRKG1, MUC1, ACTC1, KRIT1, AR
44oxygen44 248.6ACTC1, MUC1, FLT4, SFTPB, PRKG1, TEK
45paraffin447.4ACTC1, TEK, SFTPB, VEGFA, KDR, FLT4
46dexamethasone44 50 28 1110.3VEGFA, MUC1, NKX2-1, KRIT1, AR, ACTC1
47serine446.9PRKG1, KDR, SFTPB, TEK, MUC1, NKX2-1
48vegf446.4VEGFA, SFTPB, KDR, FLT4, MUC1, IFNA2
49estrogen446.3KRIT1, NKX2-1, ACTC1, MUC1, IFNA2, VEGFA
50tyrosine446.3SFTPB, ACTC1, IFNA2, PRKG1, MUC1, FLT4

GO Terms for genes affiliated with Hemangioma

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Cellular components related to Hemangioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1actin filamentGO:0058849.9ACTC1, TEK
2cell-cell junctionGO:0059119.2TEK, KRIT1, SLC2A1
3extracellular regionGO:0055768.4TEK, SFTPA1, VEGFA, KDR, FLT4, IFNA2
4extracellular spaceGO:0056158.2KRIT1, ACTC1, IFNA2, VEGFA, SFTPA1, SFTPB
5cytoplasmGO:0057376.6TEK, VEGFA, FLT4, MUC1, PRKG1, ACTC1

Biological processes related to Hemangioma according to GeneCards/GeneDecks:

(show all 30)
idNameGO IDScoreTop Affiliating Genes
1lymph vessel developmentGO:00194510.3KDR, FLT4
2positive regulation of protein kinase C signalingGO:09003710.2VEGFA, FLT4
3surfactant homeostasisGO:04312910.2VEGFA, KDR
4positive regulation of positive chemotaxisGO:05092710.2KDR, VEGFA
5positive regulation of intracellular signal transductionGO:190253310.1VEGFA, TEK
6cell migration involved in sprouting angiogenesisGO:00204210.1KDR, VEGFA
7sprouting angiogenesisGO:00204010.1FLT4, TEK
8branching morphogenesis of an epithelial tubeGO:04875410.0KDR, VEGFA
9cellular response to vascular endothelial growth factor stimulusGO:03592410.0FLT4, KDR, VEGFA
10transmembrane receptor protein tyrosine kinase signaling pathwayGO:00716910.0TEK, KDR, FLT4
11vascular endothelial growth factor receptor signaling pathwayGO:04801010.0VEGFA, KDR, FLT4
12peptidyl-tyrosine phosphorylationGO:01810810.0TEK, KDR, FLT4
13positive regulation of ERK1 and ERK2 cascadeGO:07037410.0FLT4, KDR, TEK
14positive regulation of focal adhesion assemblyGO:0518949.9TEK, VEGFA, KDR
15positive regulation of mesenchymal cell proliferationGO:0020539.9KDR, VEGFA
16positive regulation of angiogenesisGO:0457669.9TEK, VEGFA, KDR
17protein autophosphorylationGO:0467779.9TEK, KDR, FLT4
18negative regulation of endothelial cell apoptotic processGO:20003529.8KRIT1, KDR, TEK
19cell maturationGO:0484699.8KDR, VEGFA
20respiratory gaseous exchangeGO:0075859.7SFTPB, SFTPA1
21positive regulation of endothelial cell migrationGO:0105959.7FLT4, KDR, VEGFA, TEK
22positive regulation of endothelial cell proliferationGO:0019389.7TEK, VEGFA, KDR, FLT4
23positive regulation of protein phosphorylationGO:0019349.7FLT4, KDR, VEGFA, TEK
24ovarian follicle developmentGO:0015419.6KDR, VEGFA
25protein oligomerizationGO:0512599.5AR, TEK
26angiogenesisGO:0015259.5KRIT1, KDR, VEGFA, TEK
27negative regulation of apoptotic processGO:0430669.4TEK, VEGFA, KDR, FLT4, ACTC1
28positive regulation of cell proliferationGO:0082849.3VEGFA, KDR, FLT4, AR
29cell-cell signalingGO:0072679.2AR, IFNA2, TEK
30blood coagulationGO:0075968.8IFNA2, PRKG1, VEGFA, TEK

Molecular functions related to Hemangioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor bindingGO:0198389.7FLT4, KDR, TEK
2vascular endothelial growth factor-activated receptor activityGO:0050219.7FLT4, KDR
3transmembrane receptor protein tyrosine kinase activityGO:0047149.6TEK, KDR, FLT4
4ATP bindingGO:0055248.6ACTC1, PRKG1, FLT4, KDR, TEK
5protein bindingGO:0055155.8TEK, VEGFA, KDR, FLT4, MUC1, PRKG1

Products for genes affiliated with Hemangioma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet