MCID: HMN010
MIFTS: 61

Hemangioma

Categories: Genetic diseases, Cancer diseases

Aliases & Classifications for Hemangioma

Summaries for Hemangioma

Disease Ontology : 12 A cell type benign neoplasm that has physical basis in endothelial cells that line blood vessels and is characterised by increased number of normal or abnormal vessels filled with blood.

MalaCards based summary : Hemangioma is related to hemangioma, capillary infantile and cavernous hemangioma. An important gene associated with Hemangioma is KDR (Kinase Insert Domain Receptor), and among its related pathways/superpathways are PAK Pathway and PI3K-Akt signaling pathway. The drugs Parecoxib and Sufentanil have been mentioned in the context of this disorder. Affiliated tissues include Heart, liver and endothelial, and related phenotypes are cardiovascular system and cellular

Wikipedia : 72 These are quite common lesions, especially in infancy and childhood. The most common sites are the skin... more...

Related Diseases for Hemangioma

Diseases in the Hemangioma family:

Malignant Hemangioma Acquired Hemangioma
Familial Hemangioma

Diseases related to Hemangioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 533)
# Related Disease Score Top Affiliating Genes
1 hemangioma, capillary infantile 34.2 ANTXR1 FLT4 KDR
2 cavernous hemangioma 33.5 KDR KRIT1 NKX2-1 PECAM1
3 glomeruloid hemangioma 33.5 CD34 VEGFA
4 hemangioma of lung 33.4 NKX2-1 SFTPB
5 capillary hemangioma 33.4 FLT4 KDR PECAM1 SLC2A1 TEK VEGFA
6 cerebral cavernous malformations 33.1 KDR KRIT1 PECAM1
7 skin hemangioma 33.1 KDR PROX1 SLC2A1 VEGFA
8 hemangioma of liver 32.9 CD34 KRIT1
9 hobnail hemangioma 32.8 CD34 FLT4 PDPN
10 pyogenic granuloma 32.7 ACTC1 ANGPT2 TEK VEGFA
11 hemangioendothelioma 32.5 FLT4 KDR PECAM1
12 epithelioid hemangioendothelioma 32.4 KDR PECAM1 VEGFA
13 intramuscular hemangioma 32.3 CD34 LYVE1 SLC2A1 TEK
14 acquired hemangioma 32.1 LYVE1 PDPN PROX1
15 angiosarcoma 31.3 FLT4 KDR PECAM1 PROX1 TEK VEGFA
16 intravascular papillary endothelial hyperplasia 30.2 ACTC1 VEGFA
17 angiokeratoma circumscriptum 30.0 KDR SLC2A1 VEGFA
18 hemifacial spasm 29.9 FLT4 VEGFA
19 lymphedema 29.7 FLT4 KDR PROX1
20 endometrial adenocarcinoma 29.6 FGF2 KRAS VEGFA
21 renal cell carcinoma, nonpapillary 29.6 FGF2 FLT4 KDR NKX2-1 SLC2A1 VEGFA
22 lymphatic malformations 29.6 FLT4 PROX1
23 gorham's disease 29.6 FLT4 PROX1
24 exudative vitreoretinopathy 1 29.4 ANGPT2 KDR TEK VEGFA
25 kaposiform hemangioendothelioma 29.1 CD34 FLT4 KDR PECAM1 PROX1
26 lymphangioma 29.0 ACTC1 FLT4 KDR PDPN PROX1 VEGFA
27 hepatocellular carcinoma 28.6 CD34 CYCS FGF2 KDR KRAS VEGFA
28 glomangioma 28.0 ACTC1 CD34 FGF2 PDPN SLC2A1 TEK
29 lung cancer 27.8 CYCS FGF2 FLT4 KDR KRAS NKX2-1
30 hemangioma-thrombocytopenia syndrome 12.2
31 non-involuting congenital hemangioma 12.2
32 sclerosing hemangioma 12.2
33 rapidly involuting congenital hemangioma 12.1
34 bone epithelioid hemangioma 12.0
35 pulmonary sclerosing hemangioma 12.0
36 spindle cell hemangioma 12.0
37 histiocytoid hemangioma 12.0
38 giant hemangioma 12.0
39 central nervous system hemangioma 11.9
40 venous hemangioma 11.9
41 hemangioma of spleen 11.9
42 gastric hemangioma 11.9
43 skin epithelioid hemangioma 11.9
44 hemangioma of subcutaneous tissue 11.9
45 supraumbilical midabdominal raphe and facial cavernous hemangiomas 11.9
46 verrucous hemangioma 11.9
47 breast hemangioma 11.9
48 malignant hemangioma 11.9
49 diffuse cavernous hemangioma of the rectum 11.8
50 hemangioma of orbit 11.8

Graphical network of the top 20 diseases related to Hemangioma:



Diseases related to Hemangioma

Symptoms & Phenotypes for Hemangioma

MGI Mouse Phenotypes related to Hemangioma:

43 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.47 ANTXR1 FLT4 ACTC1 CYCS ANGPT2 FGF2
2 cellular MP:0005384 10.43 FGF2 ANTXR1 CD34 ACTC1 CYCS ANGPT2
3 homeostasis/metabolism MP:0005376 10.4 FGF2 CD34 FLT4 ACTC1 ANGPT2 DIO3
4 growth/size/body region MP:0005378 10.37 ANTXR1 FLT4 CYCS ACTC1 DIO3 NKX2-1
5 mortality/aging MP:0010768 10.33 ANTXR1 FLT4 ACTC1 CYCS ANGPT2 DIO3
6 immune system MP:0005387 10.26 ANTXR1 CD34 CYCS ANGPT2 LYVE1 KRAS
7 hematopoietic system MP:0005397 10.25 FGF2 CD34 CYCS LYVE1 KRAS KDR
8 digestive/alimentary MP:0005381 10.15 ANGPT2 KRAS FLT4 PECAM1 NKX2-1 PROX1
9 embryo MP:0005380 10.14 CYCS KRIT1 KDR FLT4 KRAS TEK
10 muscle MP:0005369 10.11 FGF2 FLT4 ACTC1 KRAS KDR KRIT1
11 integument MP:0010771 10.06 CD34 ANGPT2 KRIT1 KDR FLT4 KRAS
12 liver/biliary system MP:0005370 9.98 DIO3 KDR FLT4 KRAS PECAM1 PROX1
13 neoplasm MP:0002006 9.87 FGF2 ANTXR1 CD34 KRAS KRIT1 NKX2-1
14 respiratory system MP:0005388 9.81 ANGPT2 NKX2-1 KRAS KDR PECAM1 PROX1
15 no phenotypic analysis MP:0003012 9.8 ANTXR1 KDR FLT4 KRAS SLC2A1 NKX2-1
16 skeleton MP:0005390 9.61 FGF2 ANTXR1 CYCS KRAS KDR PECAM1
17 vision/eye MP:0005391 9.23 FGF2 ANGPT2 KDR KRAS KRIT1 TEK

Drugs & Therapeutics for Hemangioma

Drugs for Hemangioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 201)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Parecoxib Approved Phase 4 198470-84-7
2
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
3
Propranolol Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 525-66-6 4946
4
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 83-43-2 6741
5
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-24-8 5755
6
Ethiodized oil Approved, Investigational Phase 4 8008-53-5
7
Dexmedetomidine Approved, Vet_approved Phase 4 76631-46-4, 113775-47-6 5311068 56032 68602
8 Adjuvants, Anesthesia Phase 4
9 Analgesics Phase 4
10 Analgesics, Non-Narcotic Phase 4
11 Analgesics, Opioid Phase 4
12 Anesthetics Phase 4
13 Anesthetics, General Phase 4
14 Anesthetics, Intravenous Phase 4
15 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2
16 Anti-Inflammatory Agents, Non-Steroidal Phase 4
17 Antirheumatic Agents Phase 4
18 Central Nervous System Depressants Phase 4
19 Cyclooxygenase 2 Inhibitors Phase 4
20 Cyclooxygenase Inhibitors Phase 4
21 Narcotics Phase 4
22 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
23 Adrenergic Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
24 Adrenergic Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
25 Adrenergic beta-Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
26 Anti-Arrhythmia Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
27 Antihypertensive Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
28 Autonomic Agents Phase 4,Phase 3,Phase 2
29 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
30 Vasodilator Agents Phase 4,Phase 3,Phase 2,Phase 1
31 Antiemetics Phase 4,Phase 3,Phase 2
32 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2
33 Gastrointestinal Agents Phase 4,Phase 3,Phase 2
34 glucocorticoids Phase 4,Phase 3,Phase 2
35 Hormone Antagonists Phase 4,Phase 3,Phase 2
36 Hormones Phase 4,Phase 3,Phase 2
37 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2
38 Methylprednisolone acetate Phase 4,Phase 3,Phase 2
39 Methylprednisolone Hemisuccinate Phase 4,Phase 3,Phase 2
40 Neuroprotective Agents Phase 4,Phase 3,Phase 2
41 Prednisolone acetate Phase 4,Phase 3,Phase 2
42 Prednisolone hemisuccinate Phase 4,Phase 3,Phase 2
43 Prednisolone phosphate Phase 4,Phase 3,Phase 2
44 Protective Agents Phase 4,Phase 3,Phase 2
45 Adrenergic Agonists Phase 4
46 Adrenergic alpha-Agonists Phase 4
47 Adrenergic alpha-2 Receptor Agonists Phase 4
48 Hypnotics and Sedatives Phase 4
49
Benzocaine Approved, Investigational Phase 3,Phase 2 1994-09-7, 94-09-7 2337
50
Nadolol Approved Phase 3,Phase 2 42200-33-9 39147

Interventional clinical trials:

(show top 50) (show all 198)

# Name Status NCT ID Phase Drugs
1 Role of Parecoxib Sodium for Postoperative Pain Management in Open Hepatectomy Unknown status NCT02204878 Phase 4 Parecoxib Sodium
2 The Safety and Efficiency of Propranolol as an Initial Treatment for Pediatric Hemangioma Completed NCT01908972 Phase 4 Prednisolone;Propranolol
3 Evaluation of Lipiodol® Ultra Fluid in Association With Surgical Glues During Vascular Embolization. Recruiting NCT02625389 Phase 4 Lipiodol® Ultra Fluid with surgical glues
4 Postmarketing Safety Study of Hemoporfin in Patients With Port Wine Stain Recruiting NCT03181984 Phase 4 Hemoporfin
5 A Pilot Study of Hemoporfin PDT in Children With Port-wine Stain Recruiting NCT03125057 Phase 4 Hemoporfin PDT
6 Effect of Dexmedetomidine Combined With Sufentanil for Postoperative Intravenous Analgesia in Neurosurgery Recruiting NCT02552459 Phase 4 Sufentanil;dexmedetomidine 1;dexmedetomidine 2;dexmedetomidine 3
7 Apollo™ Onyx™ Delivery Micro Catheter Post Market Safety Study Active, not recruiting NCT02378883 Phase 4
8 Visceral Artery Aneurysm Embolization by the Penumbra Ruby™ Coil System Not yet recruiting NCT02079818 Phase 4
9 Nadolol Versus Propranolol in Children With Infantile Hemangiomas Unknown status NCT02505971 Phase 3 Nadolol;Propranolol
10 Topical Timolol for Superficial Infantile Hemangioma Unknown status NCT01685398 Phase 3 0.5% timolol maleate eye drop;Normal saline
11 Treatment of Port Wine Stains in Children With Pulsed Dye Laser and Timolol Gel Unknown status NCT01272609 Phase 3 Timolol + LCP
12 Functional Magnetic Resonance Imagine(fMRI)Navigation in Intracranial Arteriovenous Malformation Surgery Unknown status NCT01758211 Phase 3
13 Study to Demonstrate the Efficacy and Safety of Propranolol Oral Solution in Infants With Proliferating Infantile Hemangiomas Requiring Systemic Therapy Completed NCT01056341 Phase 2, Phase 3 Propranolol;Placebo
14 Pulse Steroids Versus Oral Steroids in Problematic Hemangiomas of Infancy Completed NCT00312520 Phase 3 prednisolone;methylprednisolone
15 Evaluation of Vertebroplasty Associated With Radiotherapy for Spine Metastases (EVAR) Completed NCT00267033 Phase 3
16 A Multicenter, Open-label Study for E7040 in Japanese Subjects With Hypervascular Tumor and Subjects With Arteriovenous Malformation Completed NCT01677624 Phase 3
17 A Randomized Trial of Unruptured Brain AVMs Completed NCT00389181 Phase 3
18 Comparative Study to Evaluate the Effectiveness of Atenolol and Propranolol in the Treatment of Infantile Hemangiomas Recruiting NCT03237637 Phase 3 oral propranolol;oral atenolol
19 CyberKnife Based Hypofractionated Radiotherapy for Vertebral Hemangiomas Recruiting NCT02332408 Phase 3
20 Efficacy and Safety of Propranolol Versus Atenolol on the Proliferative Phase of Infantile Hemangioma Recruiting NCT02342275 Phase 3 Propranolol;Atenolol
21 Trial of Sirolimus for Cognitive Impairment in Sturge-Weber Syndrome Recruiting NCT03047980 Phase 2, Phase 3 Sirolimus
22 MELABLOCK: A Clinical Trial on the Efficacy and Safety of Propranolol 80 mg in Melanoma Patients Not yet recruiting NCT02962947 Phase 2, Phase 3 Propranolol;Placebo
23 Propranolol in Capillary Hemangiomas Terminated NCT00744185 Phase 2, Phase 3 propranolol treatment;placebo treatment
24 Efficacy and Safety of Propranolol Versus Acebutolol on the Proliferative Phase of Infantile Hemangioma Terminated NCT01743885 Phase 3 Acebutolol;Propanolol
25 Topical Timolol Gel for the Treatment of Infantile Hemangiomas Completed NCT02145884 Phase 2 timolol maleate 0.5% gel
26 Nadolol for Proliferating Infantile Hemangiomas Completed NCT01010308 Phase 2 Nadolol
27 A Phase II Study of Imiquimod 5 % Cream for the Treatment of Hemangioma in Infancy Completed NCT00601016 Phase 2 Imiquimod 5% cream
28 Study in Infants With Infantile Hemangioma to Compare Propranolol Gel to Placebo Completed NCT01512173 Phase 2 propranolol gel;Placebo
29 Comparative Study of the Use of Beta Blocker and Oral Corticosteroid in the Treatment of Infantile Hemangioma Completed NCT01072045 Phase 2 Propranolol;Prednisone
30 Efficacy of a Timolol Nasal Spray as a Treatment for Epistaxis in Hereditary Hemorrhagic Telangiectasia (HHT) - (TEMPO) Completed NCT02484716 Phase 2 Timolol nasal spray;Placebo nasal spray
31 Measurement Skin Temperature During Pulsed Laser Exposure Completed NCT00540917 Phase 2
32 Treatment of Resistant Port-wine Stains With Bosentan and Pulsed Dye Laser: a Pilot Study Completed NCT02317679 Phase 2 Bosentan
33 The Effects of Aldara as an Adjunct to Laser Treatment Completed NCT00979550 Phase 2 Imiquimod (Aldara);non-medicated petroleum cream
34 Study Comparing Onyx and TRUFILL in Brain Arteriovenous Malformations (AVMs) Completed NCT00857662 Phase 2
35 Phase II Trial of Sunitinib (SU011248) in Patients With Recurrent or Inoperable Meningioma Completed NCT00589784 Phase 2 Sunitinib
36 Treatment of Von Hippel-Lindau (VHL)-Related Hemangioblastoma With PTK787/ZK 222584 Completed NCT00052013 Phase 2 PTK787/ZK 222584
37 Thalidomide Reduces Arteriovenous Malformation Related Gastrointestinal Bleeding Completed NCT00389935 Phase 2 Thalidomide
38 Efficacy and Safety Study of Topical Rapamycin Associated With Pulsed Dye Laser in Patients With Sturge-Weber Syndrome Completed NCT02080624 Phase 2 Drug: Topical Rapamycin
39 Vismodegib and Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Advanced or Metastatic Sarcoma Completed NCT01154452 Phase 1, Phase 2 Gamma-Secretase Inhibitor RO4929097;Vismodegib
40 Efficacy, Safety and Pharmacokinetics of Topical Timolol in Infants With Infantile Hemangioma (IH) Recruiting NCT02913612 Phase 2 0.25% Timolol Maleate Gel Forming Solution;0.5% Timolol Maleate Gel Forming Solution
41 Topical Timolol for Infantile Hemangioma in Early Proliferative Phase Recruiting NCT02731287 Phase 2 Timolol;Placebo
42 A Study to Compare Vincristine to Sirolimus for Treatment of High Risk Vascular Tumors Recruiting NCT02110069 Phase 2 Vincristine;Sirolimus
43 A Phase I/II Trial for Intravitreous Treatment of Severe Ocular Von Hippel-Lindau Disease Using a Combination of the PDGF Antagonist E10030 and the VEGF Antagonist Ranibizumab Recruiting NCT02859441 Phase 1, Phase 2 Ranibizumab;E10030
44 A Safety and Efficacy Trial of Circumferential Anal Canal Radiofrequency Ablation for High-Grade Anal Intraepithelial Neoplasia Using the BARRX™ Anorectal Wand Recruiting NCT03302858 Phase 2
45 Prospective Evaluation of the Efficacy of Sirolimus (Rapamune®) in the Treatment of Severe Arteriovenous Malformations Recruiting NCT02042326 Phase 2 Sirolimus
46 Trametinib in Treating Patients With Epithelioid Hemangioendothelioma That Is Metastatic, Locally Advanced, or Cannot Be Removed by Surgery Recruiting NCT03148275 Phase 2 Trametinib
47 Proton Radiotherapy for Primary Central Nervous System Tumours in Adults Recruiting NCT02797366 Phase 2
48 Eribulin in Angiosarcoma and Epithelioid Hemangioendothelioma (EHE) Recruiting NCT03331250 Phase 2 Eribulin
49 Sirolimus Versus Sirolimus Plus Prednisolone for Kaposiform Hemangioendothelioma With Kasabach-Merritt Syndrome Recruiting NCT03188068 Phase 2 Sirolimus;Prednisolone
50 Gemcitabine Hydrochloride With or Without Pazopanib Hydrochloride in Treating Patients With Refractory Soft Tissue Sarcoma Recruiting NCT01532687 Phase 2 Gemcitabine Hydrochloride;Pazopanib Hydrochloride

Search NIH Clinical Center for Hemangioma

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: hemangioma

Genetic Tests for Hemangioma

Genetic tests related to Hemangioma:

# Genetic test Affiliating Genes
1 Hemangioma 28

Anatomical Context for Hemangioma

MalaCards organs/tissues related to Hemangioma:

38
Liver, Endothelial, Lung, Skin, Brain, Bone, Breast
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Hemangioma:
# Tissue Anatomical CompartmentCell Relevance
1 Heart Cardinal Veins Venous Endothelial Cells Affected by disease

Publications for Hemangioma

Articles related to Hemangioma:

(show top 50) (show all 2521)
# Title Authors Year
1
Orbital Cavernous Hemangioma Causing Spontaneous Compressive Hemorrhage. ( 29419596 )
2018
2
Linear verrucous hemangioma-a rare case and dermoscopic clues to diagnosis. ( 29445574 )
2018
3
Venous outlet syndrome caused by capillary hemangioma of the subclavian vein. ( 29444598 )
2018
4
Analysis of the characteristics of optical coherence tomography angiography for retinal cavernous hemangioma: A case report. ( 29443780 )
2018
5
Hemorrhagic cavernous sinus hemangioma with sudden onset abducens palsy - case report. ( 29325944 )
2018
6
Optic Nerve Meningioma Mimicking Cavernous Hemangioma. ( 29191527 )
2018
7
Selective hemangioma cell dysfunction and apoptosis triggered by in vitro treatment with imiquimod. ( 29410238 )
2018
8
Hemangioma of the Hard Palate in an Elderly Patient as a Life-Threatening Surgical Emergency. ( 29438210 )
2018
9
Risk of infantile hemangiomas in the offspring of women with autoimmune disease and the pathogenic implications of these lesions. ( 29341431 )
2018
10
Dural Penetration of Cavernous Hemangioma on Skull: Uncommon Clinical Presentation. ( 29109062 )
2018
11
Solitary Retinal Capillary Hemangioma with Nonlipid Exudative Retinal Detachment. ( 29389404 )
2018
12
Endoscopic management of Atypical sellar cavernous hemangioma: A case report and review of the literature. ( 29248833 )
2018
13
Long-Term Therapeutic Outcomes of Photodynamic Therapy-Based or Photocoagulation-Based Treatments on Retinal Capillary Hemangioma. ( 29068750 )
2018
14
Curcumin induces apoptosis and inhibits proliferation in infantile hemangioma endothelial cells via downregulation of MCL-1 and HIF-1I+. ( 29443732 )
2018
15
A new surgical technique for excision of orbital cavernous hemangioma: a 15-year experience. ( 29442536 )
2018
16
Topical timolol for an iris hemangioma. ( 29412149 )
2018
17
An unusual lesion on the nose: microvenular hemangioma. ( 29445567 )
2018
18
Primary Spleen Angiosarcoma With Concomitant Hepatic Hemangiomas on 18F-FDG PET/CT. ( 29356748 )
2018
19
Combined Oral and Topical Beta Blockers for the Treatment of Early Proliferative Superficial Periocular Infantile Capillary Hemangioma. ( 28991344 )
2018
20
Optical Coherence Tomography Microangiography Imaging of Circumscribed Choroidal Hemangioma. ( 29443364 )
2018
21
Ultrasound findings in rapidly involuting congenital hemangioma (RICH) - beware of venous ectasia and venous lakes. ( 29362838 )
2018
22
Moyamoya Disease Associated with Tuberculum Sellae Meningioma and Cavernous Sinus Hemangioma. ( 28958924 )
2018
23
Factors associated with delayed referral for infantile hemangioma necessitating propranolol. ( 29405477 )
2018
24
Results of external beam radiotherapy for diffuse choroidal hemangiomas in Sturge-Weber syndrome. ( 29403070 )
2018
25
Spinal hemangioma mimicking a dumbbell-shaped schwannoma: Case report and review of the literature. ( 29398191 )
2018
26
Genital tract cavernous hemangioma as a rare cause of postpartum hemorrhage. ( 28989925 )
2017
27
An Unusual Differential Diagnosis of Orbital Cavernous Hemangioma: Ancient Schwannoma. ( 28626414 )
2017
28
A Giant Cavernous Hemangioma of the Left Atrioventricular Groove. ( 28409047 )
2017
29
SOLITARY RETINAL CAPILLARY HEMANGIOMA IN A PATIENT WITH BILATERAL CHORIORETINAL COLOBOMA. ( 28358746 )
2017
30
Concomitant Intraocular Retinoblastoma and Choroidal Hemangioma in a 1-Year-Old Boy. ( 28984344 )
2017
31
Mixed Hemangioma of the Nasal Cavity Destructing the Nasal Bone. ( 28060104 )
2017
32
Intrasellar cavernous hemangioma presenting as pituitary adenoma: A report of two cases and review of the literature. ( 29189199 )
2017
33
Cutaneous Glomeruloid Hemangioma: A Report on Two Cases and a Review of Literature. ( 28813760 )
2017
34
Swept source optical coherence tomography-angiography of choroid in choroidal hemangioma before and after laser photocoagulation. ( 28820167 )
2017
35
A Rare Cause of Hemoptysis in Childhood: Tracheal Capillary Hemangioma. ( 29404177 )
2017
36
A rare case of diffuse neurofibroma masquerading as a hemangioma: a radiological perspective. ( 29204240 )
2017
37
Optical Coherence Tomography Angiography of Retinal Cavernous Hemangioma. ( 28423387 )
2017
38
Spitz Nevus Intermingling With Hemangioma, Angiomatoid Spitz Nevus, Angiotropism, and Vascular Co-option Viewed With Differing Availability Heuristics. ( 28398920 )
2017
39
A Case of Retinal Cavernous Hemangioma Diagnosed with Spectral Domain Optical Coherence Tomography. ( 28534341 )
2017
40
Utility of the Hemangioma Severity Scale as a Triage Tool and Predictor of Need for Treatment. ( 27981617 )
2017
41
Giant hemangioma of anterior mediastinum mimicking bilateral pleural effusion. ( 29354184 )
2017
42
Common Skin Conditions in Children: Congenital Melanocytic Nevi and Infantile Hemangiomas. ( 28196319 )
2017
43
Optical coherence tomography angiography in retinal cavernous hemangioma. ( 29259920 )
2017
44
Intratumoral coagulation by radiofrequency ablation facilitated the laparoscopic resection of giant hepatic hemangioma: a surgical technique report of two cases. ( 28881707 )
2017
45
The Art of Mimicry: Anterior Clinoid Dural-Based Cavernous Hemangioma Mistaken for a Meningioma. ( 28214640 )
2017
46
A primary cavernous hemangioma of the thyroid gland: A case report and literature review. ( 29245224 )
2017
47
Cardiac tamponade due to apixaban therapy in patient with unknown pericardial hemangioma. ( 28803417 )
2017
48
Posttraumatic Intramuscular Hemangioma Arising from Scalene Muscles in Supraclavicular Region. ( 29392062 )
2017
49
Rapamycin inhibits the proliferation of endothelial cells in hemangioma by blocking the mTOR-FABP4 pathway. ( 27914823 )
2017
50
Intradural-extramedullary capillary hemangioma with acute bleeding, case report and literature review. ( 28823662 )
2017

Variations for Hemangioma

Expression for Hemangioma

Search GEO for disease gene expression data for Hemangioma.

Pathways for Hemangioma

Pathways related to Hemangioma according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.21 ANGPT2 FGF2 FLT4 KDR KRAS SLC2A1
2
Show member pathways
12.8 ANGPT2 FGF2 FLT4 KDR KRAS TEK
3 12.69 CYCS FGF2 FLT4 KRAS SLC2A1 VEGFA
4 12.53 ANGPT2 FGF2 FLT4 KDR KRAS TEK
5
Show member pathways
12.45 ANGPT2 CYCS FGF2 KRAS VEGFA
6
Show member pathways
12.4 ANGPT2 FGF2 FLT4 KDR KRAS KRIT1
7
Show member pathways
12.3 FGF2 FLT4 KDR VEGFA
8
Show member pathways
12.27 FLT4 KDR KRAS VEGFA
9 12.21 FGF2 KDR KRAS VEGFA
10
Show member pathways
12.14 ANGPT2 KRAS PECAM1 TEK
11
Show member pathways
12.13 FGF2 KDR KRAS VEGFA
12 11.95 FGF2 KDR PROX1 VEGFA
13 11.93 ANGPT2 FGF2 FLT4 KDR TEK
14
Show member pathways
11.77 FLT4 KDR VEGFA
15 11.76 ANGPT2 SLC2A1 TEK VEGFA
16
Show member pathways
11.71 FLT4 KDR KRAS
17 11.68 FGF2 SLC2A1 VEGFA
18 11.47 ACTC1 FGF2 KDR
19 11.42 FGF2 KDR VEGFA
20 11.39 FGF2 KDR VEGFA
21 11.25 ANGPT2 SLC2A1 VEGFA
22 11.18 KDR SLC2A1 VEGFA
23 11.11 ANGPT2 FGF2 FLT4 KDR PECAM1 PROX1
24 10.98 FGF2 FLT4 KDR KRAS VEGFA
25 10.94 FGF2 KDR TEK VEGFA
26 10.93 ANGPT2 FGF2 FLT4 KDR TEK
27
Show member pathways
10.78 FLT4 KDR VEGFA

GO Terms for Hemangioma

Cellular components related to Hemangioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.97 ANGPT2 ANTXR1 CD34 DIO3 FLT4 KDR
2 cell periphery GO:0071944 9.13 CD34 LYVE1 PECAM1
3 membrane raft GO:0045121 9.1 KDR KRAS PDPN PECAM1 SLC2A1 TEK

Biological processes related to Hemangioma according to GeneCards Suite gene sharing:

(show all 38)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.93 FGF2 FLT4 KDR TEK
2 peptidyl-tyrosine phosphorylation GO:0018108 9.9 FGF2 FLT4 KDR TEK
3 negative regulation of angiogenesis GO:0016525 9.84 ANGPT2 KRIT1 TEK
4 leukocyte migration GO:0050900 9.83 ANGPT2 CD34 KRAS PECAM1 TEK
5 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.82 FLT4 KDR VEGFA
6 positive regulation of MAP kinase activity GO:0043406 9.8 FGF2 KRAS VEGFA
7 lung development GO:0030324 9.78 NKX2-1 PDPN PROX1 VEGFA
8 positive regulation of protein phosphorylation GO:0001934 9.77 FLT4 KDR KRAS TEK VEGFA
9 positive regulation of blood vessel endothelial cell migration GO:0043536 9.74 FGF2 KDR VEGFA
10 positive regulation of angiogenesis GO:0045766 9.73 ANGPT2 CD34 FGF2 KDR TEK VEGFA
11 angiogenesis GO:0001525 9.7 ANGPT2 FGF2 FLT4 KDR KRIT1 TEK
12 negative regulation of endothelial cell apoptotic process GO:2000352 9.69 KDR KRIT1 TEK
13 endothelial cell proliferation GO:0001935 9.68 CD34 TEK
14 epithelial tube branching involved in lung morphogenesis GO:0060441 9.67 KRAS NKX2-1
15 hyaluronan catabolic process GO:0030214 9.67 FGF2 LYVE1
16 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.67 FLT4 KDR VEGFA
17 positive regulation of positive chemotaxis GO:0050927 9.66 KDR VEGFA
18 lymph vessel development GO:0001945 9.66 FLT4 PROX1
19 positive regulation of cellular component movement GO:0051272 9.65 PDPN VEGFA
20 positive regulation of vasculogenesis GO:2001214 9.65 CD34 KDR
21 stem cell proliferation GO:0072089 9.64 CD34 FGF2
22 positive regulation of protein kinase C signaling GO:0090037 9.64 FLT4 VEGFA
23 vascular endothelial growth factor signaling pathway GO:0038084 9.63 FLT4 KDR
24 positive regulation of focal adhesion assembly GO:0051894 9.63 KDR TEK VEGFA
25 skeletal muscle thin filament assembly GO:0030240 9.61 ACTC1 PROX1
26 endothelium development GO:0003158 9.61 CD34 KDR
27 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.59 KDR VEGFA
28 actin-mediated cell contraction GO:0070252 9.58 ACTC1 PDPN
29 glomerulus vasculature development GO:0072012 9.58 ANGPT2 TEK
30 cell migration involved in sprouting angiogenesis GO:0002042 9.58 FGF2 KDR VEGFA
31 Tie signaling pathway GO:0048014 9.54 ANGPT2 TEK
32 glomerular endothelium development GO:0072011 9.52 CD34 PECAM1
33 lymphangiogenesis GO:0001946 9.5 FLT4 PDPN PROX1
34 positive regulation of endothelial cell migration GO:0010595 9.35 FLT4 KDR PROX1 TEK VEGFA
35 positive regulation of endothelial cell proliferation GO:0001938 9.1 FGF2 FLT4 KDR PROX1 TEK VEGFA
36 negative regulation of apoptotic process GO:0043066 10.03 ACTC1 FLT4 KDR PDPN TEK VEGFA
37 positive regulation of gene expression GO:0010628 10.02 ACTC1 CD34 KRAS NKX2-1 VEGFA
38 positive regulation of cell proliferation GO:0008284 10.02 FGF2 FLT4 KDR KRAS PROX1 VEGFA

Molecular functions related to Hemangioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.33 FLT4 KDR TEK
2 vascular endothelial growth factor-activated receptor activity GO:0005021 9.26 FLT4 KDR
3 protein tyrosine kinase activity GO:0004713 9.26 FGF2 FLT4 KDR TEK
4 growth factor binding GO:0019838 8.8 FLT4 KDR TEK

Sources for Hemangioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
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36 KEGG
37 LifeMap
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41 MeSH
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58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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