MCID: HMN010
MIFTS: 68

Hemangioma malady

Summaries for Hemangioma

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A cell type benign neoplasm that has physical basis in endothelial cells that line blood vessels and is characterised by increased number of normal or abnormal vessels filled with blood.

MalaCards: Hemangioma is related to cavernous hemangioma and capillary hemangioma. An important gene associated with Hemangioma is KDR (kinase insert domain receptor (a type III receptor tyrosine kinase)), and among its related pathways are PI3K-Akt signaling pathway and Angiogenesis. The drugs interferon alfa-2a and interferon alfa-2b and the compounds vegf and tyrosine have been mentioned in the context of this disorder. Affiliated tissues include endothelial, liver and lung, and related mouse phenotypes are cardiovascular system and nervous system.

Wikipedia:63 A hemangioma is a benign and usually self-involuting tumor (swelling or growth) of the endothelial cells... more...

Aliases & Classifications for Hemangioma

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 39NCIt
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Aliases & Descriptions:

hemangioma 8 42 10 44 60


Related Diseases for Hemangioma

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17GeneCards, 18GeneDecks
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Diseases in the Hemangioma family:

Acquired Hemangioma Familial Hemangioma

Diseases related to Hemangioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 502)
idRelated DiseaseScoreTop Affiliating Genes
1cavernous hemangioma31.6KRIT1
2capillary hemangioma31.5SLC2A1
3sclerosing hemangioma31.2SFTPB
4hemangioma of lung31.0SFTPB
5hepatitis31.0KRIT1, PRKG1, IFNA2
6klippel-trenaunay syndrome30.6KRIT1, FLT4
7von hippel-lindau disease30.4VEGFA
8retinal disease30.4VEGFA, KDR, SLC2A1, TEK
9angiosarcoma30.3KDR, MUC1, FLT4, ACTC1, TEK, PECAM1
10cerebral cavernous malformation30.3PECAM1, KRIT1, KDR
11hemangioma, capillary infantile30.2FLT4, KDR
12sarcoma30.2ACTC1, KDR, MUC1, PRKG1, FLT4, AR
13hepatocellular carcinoma30.2TEK, KRIT1, SLC2A1, KDR, VEGFA, NKX2-1
14adenoma30.2FLT4, PRKG1, NKX2-1, SYP, MUC1, SLC2A1
15lymphangioma30.2FLT4, PROX1, ACTC1, PECAM1, LYVE1
16meningioma30.1SLC2A1, MUC1, SYP
17deficiency anemia30.1IFNA2
18adenocarcinoma30.1SFTPB, AR, FLT4, NKX2-1, SYP, SYNM
19arteriovenous malformation30.1SLC2A1, PECAM1
20melanoma30.0IFNA2, FLT4, NKX2-1, VEGFA, KDR, ACTC1
21pyogenic granuloma30.0LYVE1, PECAM1, TEK, ACTC1, SLC2A1, FLT4
22hemangioblastoma30.0SLC2A1, KDR, MUC1, VEGFA, SYP
23fibrosarcoma30.0ACTC1
24kaposi's sarcoma29.9TEK, KDR, VEGFA, FLT4, IFNA2, PECAM1
25lung adenocarcinoma29.9SFTPB, FLT4, NKX2-1, VEGFA, MUC1, KDR
26neuroblastoma29.9SYP
27angiomyolipoma29.9ACTC1
28breast cancer29.8AR, FLT4, PROX1, VEGFA, MUC1, KDR
29papillary carcinoma29.8NKX2-1, SYP, MUC1, SLC2A1, ACTC1
30thyroid cancer29.8NKX2-1, KDR, SLC2A1, TEK
31renal clear cell carcinoma29.8VEGFA, MUC1, KDR, SLC2A1
32hemangioendothelioma29.8IFNA2, FLT4
33glomus tumor29.8ACTC1, SYP
34hemangioma, capillary infantile, somatic29.8FLT4, KDR
35medulloblastoma29.8ACTC1, SYNM, SYP
36papilloma29.8IFNA2, FLT4
37non-small cell lung carcinoma29.6FLT4, NKX2-1, SYP, VEGFA, KDR, SLC2A1
38leukemia29.6IFNA2, FLT4, PRKG1, KDR, KRIT1, TEK
39ovarian cancer29.6FLT4, NKX2-1, VEGFA, MUC1, KDR, SLC2A1
40endometrial carcinoma29.6FLT4, NKX2-1, VEGFA, SLC2A1, TEK
41astrocytoma29.6SYP, VEGFA, KDR, SLC2A1, TEK
42lung small cell carcinoma29.6FLT4, NKX2-1, SYP, MUC1, KDR
43colon cancer29.6FLT4, VEGFA, KDR, KRIT1
44lung cancer29.6VEGFA, SYP, NKX2-1, PRKG1, SFTPB
45colorectal cancer29.6KDR, VEGFA, NKX2-1, FLT4, IFNA2
46neuroendocrine carcinoma29.6MUC1, SYNM, SYP, NKX2-1
47lymphedema29.6LYVE1, PROX1, FLT4
48papillary adenocarcinoma29.6SLC2A1, MUC1, NKX2-1
49inflammatory breast carcinoma29.6PROX1, TEK, LYVE1
50leiomyoma29.6ACTC1, PRKG1

Graphical network of the top 20 diseases related to Hemangioma:



Diseases related to hemangioma

Clinical Features for Hemangioma

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Drugs & Therapeutics for Hemangioma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Hemangioma

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Anatomical Context for Hemangioma

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30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Hemangioma:

32
Endothelial, Liver, Lung, Bone, Skin, Breast, Colon, Thyroid, Spinal cord, Kidney, Testis, Spleen, Tongue, Cervix, Small intestine, Brain, Heart, Retina, Lymph node, Uterus, B cells, Adrenal gland, Placenta, Eye, Pituitary, Myeloid, Testes, Trachea, Thymus, Fetal lung, Fetal liver, Appendix, Thalamus, Smooth muscle, Monocytes, Skeletal muscle, Tonsil, Adipocyte, Pancreas, Prostate, Salivary gland, Ovary

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Hemangioma:
id TissueAnatomical CompartmentCell Relevance
1 HeartCardinal VeinsVenous Endothelial Cells Affected by disease

Animal Models for Hemangioma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Hemangioma:

36 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538511.3LYVE1, AR, FLT4, PROX1, PRKG1, NKX2-1
2MP:000363111.2AR, NETO2, PROX1, PRKG1, NKX2-1, SYP
3MP:001076811.1PRKG1, PROX1, FLT4, AR, SFTPB, NKX2-1
4MP:000538411.1AR, PROX1, PRKG1, NKX2-1, VEGFA, KDR
5MP:000287311.1AR, FLT4, PROX1, PRKG1, SYP, VEGFA
6MP:000538111.1AR, FLT4, PROX1, PRKG1, NKX2-1, VEGFA
7MP:000537610.9AR, PROX1, ACTC1, PECAM1
8MP:000539710.8PROX1, PRKG1, VEGFA, KDR, TEK, PECAM1
9MP:000537010.8AR, FLT4, PROX1, VEGFA, MUC1, KDR
10MP:000536910.8PRKG1, KDR, ACTC1
11MP:000301210.7FLT4, NKX2-1, SYP, VEGFA, MUC1, KDR
12MP:000538010.5AR, FLT4, VEGFA, KDR, SLC2A1, KRIT1

Publications for Hemangioma

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50PubMed
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Articles related to Hemangioma:

(show top 50)    (show all 1972)
idTitleAuthorsYear
1
Angiomatous Kaposi Sarcoma: A Variant That Mimics Hemangiomas. (24067801)
2013
2
Thoracic vertebral hemangioma causing paraplegia in Klippel-Trenaunay-Weber syndrome: case report. (24101274)
2013
3
Infantile hemangiomas and retinopathy of prematurity: clues to the regulation of vasculogenesis. (23408311)
2013
4
Spinal epidural arteriovenous hemangioma mimicking lumbar disc herniation. (23133733)
2012
5
Periocular epithelioid hemangioma: response to bevacizumab and vascular pathogenesis. (22965602)
2012
6
Treatment of 28 patients with sclerosing hemangioma (SH) of the lung. (22515818)
2012
7
Radiotherapy as a risk factor for malignant melanoma after childhood skin hemangioma. (22082956)
2012
8
RICH (rapidly involuting congenital hemangioma): not only a definition of wealth. (22497907)
2012
9
Acute presentation of cavernous hemangioma of the orbit. (21780934)
2011
10
Vitreoretinal surgery for severe retinal capillary hemangiomas in von hippel-lindau disease. (20801520)
2011
11
Localized cavernous hemangioma of the uterus involving adenomyotic foci. (21546746)
2011
12
Sclerosing hemangioma in the liver. (22102394)
2011
13
Surgery for Pulmonary Sclerosing Hemangioma: Lobectomy versus Limited Resection. (22263122)
2011
14
Soluble receptors for vascular endothelial growth factor (sVEGFR1/sVEGFR2) in infantile hemangioma. (20854187)
2010
15
Optochiasmatic cavernous hemangioma. (20465461)
2010
16
Venous hemangioma presenting as a superior sulcus tumor. (21095359)
2010
17
Primary intraosseous cavernous hemangioma of the metacarpal bone: a very rare entity. Case report. (19366066)
2009
18
Sclerosing hemangioma with an air halo. (19026830)
2008
19
Intramedullary spinal arteriovenous malformation in a boy of familial cerebral cavernous hemangioma. (18157540)
2008
20
A rare intramuscular hemangioma - case report. (23133075)
2008
21
Electrocorticography discharge patterns in patients with a cavernous hemangioma and pharmacoresistent epilepsy. (17886546)
2007
22
Retinal capillary hemangioma in von Hippel-Lindau disease. (16049535)
2005
23
Liver transplantation after backtable resection of giant hemangioma. (15973725)
2005
24
Cavernous hemangioma of the gallbladder. Case report and review of the literature. (16459643)
2005
25
Craniofacial cavernous hemangioma: succesful treatment with methylprednisolone. (16001100)
2005
26
Expression of the estrogen receptor beta in 37 surgically treated pulmonary sclerosing hemangiomas in comparison with non-small cell lung carcinomas. (16226111)
2005
27
Capillary hemangioma of the calvaria. (12845203)
2003
28
Retinal capillary hemangioma treatment by indocyanine green-mediated photothrombosis. (12614766)
2003
29
Cavernous hemangioma of the temporal muscle. (11954767)
2002
30
Intracranial cavernous hemangioma in a neonate. (11511998)
2001
31
Soft-tissue hemangiomas in infants and children: diagnosis using Doppler sonography. (9648798)
1998
32
Monoclonality of both pale cells and cuboidal cells of sclerosing hemangioma of the lung. (9546367)
1998
33
Giant hemangioma of the sternocleidomastoid muscle: report of a case. (9024361)
1997
34
Capillary hemangioma--report of a case. (9522754)
1996
35
Mortality from leukemia after irradiation in infancy for skin hemangioma. (8619025)
1996
36
Capillary hemangioma of the vocal cord. (7628325)
1995
37
Venous hemangioma of the mesoappendix: report of a case and a brief review of the Japanese literature. (8640022)
1995
38
Testicular juvenile capillary hemangioma: conservative management with frozen-section examination. A case report. (7982154)
1994
39
Treatment of a capillary hemangioma with the flashlamp pumped-dye laser. (2298954)
1990
40
Tumors after radiotherapy for skin hemangioma in childhood. A case-control study. (2206565)
1990
41
Synovial venous hemangioma of the knee joint. (2774881)
1989
42
Histiocytoid hemangioma of the innominate vein. (3065750)
1988
43
Renal hemangioma and renal artery aneurysm in the Klippel-Trenaunay syndrome. (2837586)
1988
44
Acquired "tufted" angioma (progressive capillary hemangioma). A distinctive clinicopathologic entity related to lobular capillary hemangioma. (3631454)
1987
45
Infiltrating angiolipoma or intramuscular hemangioma? A report of five cases. (3958171)
1986
46
Fine needle aspiration cytology of sclerosing hemangioma of the lung, a mimicker of bronchioloalveolar carcinoma. (3004083)
1986
47
Is sclerosing hemangioma of lung an alveolar mixed tumour? (6310472)
1983
48
Giant hemangioma of the liver. (5074786)
1972
49
Hypomelia-hypotrichosis-facial hemangioma syndrome (pseudothalidomide, SC syndrome, SC phocomelia syndrome). (5033248)
1972
50
Thrombocytopenia and giant hemangioma in infants. (13248227)
1955

Genetic Variations for Hemangioma

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Expression for genes affiliated with Hemangioma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hemangioma

Search GEO for disease gene expression data for Hemangioma.

Pathways for genes affiliated with Hemangioma

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Sources:
29KEGG, 4Cell Signaling Technology, 52R&D Systems, 49PharmGKB, 55SinoBiological, 51QIAGEN, 12EMD Millipore, 37NCBI BioSystems Database, 53Reactome
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Compounds for genes affiliated with Hemangioma

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44Novoseek, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 49PharmGKB, 2BitterDB
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Compounds related to Hemangioma according to GeneCards/GeneDecks:

(show top 50)    (show all 73)
idCompoundScoreTop Affiliating Genes
1vegf4411.6PROX1, FLT4, AR, IFNA2, SFTPB, PRKG1
2tyrosine4411.6FLT4, IFNA2, SFTPB, PECAM1, KDR, MUC1
3paraffin4411.6MUC1, SYP, LYVE1, PECAM1, TEK, SFTPB
4retinoic acid44 2412.4SFTPB, ACTC1, KDR, MUC1, SYP, NKX2-1
5matrigel4411.3MUC1, PECAM1, TEK, ACTC1, KDR, VEGFA
6cysteine4411.3PECAM1, SLC2A1, KDR, MUC1, SYP, IFNA2
7ribonucleic acid4411.3MUC1, PECAM1, TEK, ACTC1, SFTPB, IFNA2
8thymidine44 2412.3TEK, PECAM1, LYVE1, IFNA2, PRKG1, MUC1
9progesterone44 59 28 11 2415.3LYVE1, MUC1, SYP, NKX2-1, AR, IFNA2
10serine4411.3PECAM1, KRIT1, SYP, NKX2-1, PRKG1, SFTPB
11dexamethasone44 49 28 1114.3NKX2-1, KDR, SLC2A1, KRIT1, VEGFA, AR
12nitric oxide44 11 2413.2KRIT1, SFTPB, MUC1, KDR, PRKG1, SYP
13oxygen44 2412.2MUC1, PECAM1, SLC2A1, PRKG1, FLT4, TEK
14actinomycin d4411.2KRIT1, PECAM1, MUC1, VEGFA, SLC2A1, AR
15formaldehyde44 2412.2NKX2-1, SYP, KRIT1, ACTC1, PECAM1, MUC1
16agar4411.2KDR, IFNA2, AR, MUC1, PECAM1, SLC2A1
17tamoxifen44 49 28 1114.2IFNA2, AR, MUC1, KDR, KRIT1, VEGFA
18testosterone44 59 11 2414.2KRIT1, ACTC1, SYP, PRKG1, AR, LYVE1
19rapamycin4411.1SLC2A1, KDR, PECAM1, VEGFA, AR, FLT4
20hematoxylin4411.1PECAM1, NKX2-1, ACTC1, SYP, MUC1
21genistein44 28 59 2 11 2416.1SYP, AR, VEGFA, SLC2A1, KRIT1, KDR
222,4-dinitrophenol4411.1NKX2-1, SLC2A1, SFTPB, AR
23mucicarmine4411.1ACTC1, NKX2-1, MUC1, SYP
24threonine4411.1PECAM1, TEK, KRIT1, PRKG1, MUC1, NKX2-1
25gold4411.1IFNA2, MUC1, KRIT1, SYP, SFTPB
26cisplatin44 49 59 1114.1SYP, SLC2A1, KDR, VEGFA, IFNA2, MUC1
27b 7234411.1ACTC1, SYP, MUC1, NKX2-1
28azd 21714411.0FLT4, VEGFA, KDR
29chloramphenicol44 2 1113.0MUC1, PRKG1, SFTPB, AR, LYVE1
30zd64744411.0KDR, VEGFA, FLT4
31cyclic amp44 2412.0SYP, KRIT1, MUC1, TEK, SFTPB, NKX2-1
32axitinib44 59 1113.0FLT4, VEGFA, KDR
33s 1004411.0ACTC1, SYP, MUC1
34progestin4411.0AR, VEGFA, MUC1, KDR
35su54164411.0VEGFA, KDR, FLT4
36reticulin4411.0SYP, ACTC1, MUC1
375fluorouracil4411.0SLC2A1, MUC1, IFNA2
38geldanamycin44 49 59 1114.0KRIT1, KDR, VEGFA, AR
39Regorafenib1110.9FLT4, KDR, TEK
40sunitinib44 49 1112.9KDR, VEGFA, FLT4
41vegfc2810.8FLT4, KDR
42ly2940024410.8FLT4, AR, VEGFA, KDR, SLC2A1
43vegfe2810.8KDR, FLT4
44glucose4410.8SLC2A1, ACTC1, MUC1, IFNA2, LYVE1, PRKG1
45procymidone4410.7LYVE1, AR
46linuron4410.7LYVE1, AR
47polyglycine4410.7LYVE1, AR
48leucovorin44 49 1112.6KDR, VEGFA, IFNA2
49glycogen44 2411.6SLC2A1, PRKG1, ACTC1, SYP, MUC1
50steroid4410.5IFNA2, SYP, AR, NKX2-1, ACTC1, LYVE1

GO Terms for genes affiliated with Hemangioma

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16Gene Ontology
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Cellular components related to Hemangioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell-cell junctionGO:00591110.6TEK, KRIT1, SLC2A1
2extracellular regionGO:00557610.5TEK, SFTPA1, IFNA2, FLT4, VEGFA, MUC1

Biological processes related to Hemangioma according to GeneCards/GeneDecks:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of endothelial cell migrationGO:01059511.1TEK, KDR, VEGFA, PROX1, FLT4
2positive regulation of endothelial cell proliferationGO:00193811.1FLT4, PROX1, VEGFA, KDR, TEK
3positive regulation of cell proliferationGO:00828411.0AR, FLT4, PROX1, VEGFA, KDR
4positive regulation of protein phosphorylationGO:00193411.0TEK, KDR, VEGFA, FLT4
5positive regulation of focal adhesion assemblyGO:05189411.0TEK, KDR, VEGFA
6negative regulation of endothelial cell apoptotic processGO:200035211.0TEK, KRIT1, KDR
7cellular response to vascular endothelial growth factor stimulusGO:03592411.0FLT4, VEGFA, KDR
8vascular endothelial growth factor receptor signaling pathwayGO:04801011.0KDR, VEGFA, FLT4
9blood coagulationGO:00759611.0IFNA2, PRKG1, VEGFA, TEK, PECAM1
10angiogenesisGO:00152511.0TEK, KRIT1, KDR, VEGFA
11peptidyl-tyrosine phosphorylationGO:01810810.9TEK, KDR, FLT4
12transmembrane receptor protein tyrosine kinase signaling pathwayGO:00716910.9FLT4, KDR, TEK
13positive regulation of MAPK cascadeGO:04341010.9AR, FLT4, KDR
14skeletal muscle thin filament assemblyGO:03024010.9PROX1, ACTC1
15positive regulation of intracellular protein kinase cascadeGO:01074010.8TEK, VEGFA
16lymph vessel developmentGO:00194510.8KDR, FLT4
17positive regulation of protein kinase C signaling cascadeGO:09003710.8VEGFA, FLT4
18positive regulation of positive chemotaxisGO:05092710.8VEGFA, KDR
19lung developmentGO:03032410.7VEGFA, NKX2-1, PROX1
20surfactant homeostasisGO:04312910.7VEGFA, KDR
21lymphangiogenesisGO:00194610.6FLT4, PROX1
22positive regulation of angiogenesisGO:04576610.6VEGFA, KDR, TEK
23mammary gland alveolus developmentGO:06074910.6VEGFA, AR
24positive regulation of ERK1 and ERK2 cascadeGO:07037410.5TEK, KDR, FLT4
25cell migration involved in sprouting angiogenesisGO:00204210.3KDR, VEGFA

Molecular functions related to Hemangioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551511.0PECAM1, IFNA2, AR, FLT4, PROX1, PRKG1
2vascular endothelial growth factor-activated receptor activityGO:00502110.6KDR, FLT4
3transmembrane receptor protein tyrosine kinase activityGO:00471410.3TEK, KDR, FLT4

Products for genes affiliated with Hemangioma

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  • Antibodies
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Sources for Hemangioma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet