MCID: HMN010
MIFTS: 62

Hemangioma malady

Summaries for Hemangioma

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Disease Ontology:8 A cell type benign neoplasm that has physical basis in endothelial cells that line blood vessels and is characterised by increased number of normal or abnormal vessels filled with blood.

MalaCards: Hemangioma is related to pyogenic granuloma and klippel-trenaunay syndrome. An important gene associated with Hemangioma is KDR (kinase insert domain receptor (a type III receptor tyrosine kinase)), and among its related pathways are PI3K-Akt signaling pathway and Angiogenesis. The drugs interferon alfa-2a and interferon alfa-2b and the compounds vegf and tyrosine have been mentioned in the context of this disorder. Related mouse phenotypes are cardiovascular system and nervous system.

Wikipedia:64 A hemangioma is a benign and usually self-involuting tumor (swelling or growth) of the endothelial cells... more...

Aliases & Classifications for Hemangioma

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 27ICD9CM, 35MeSH, 40NCIt
See all sources

Aliases & Descriptions:

hemangioma 8 43 10 45 61


Related Diseases for Hemangioma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Hemangioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 495)
idRelated DiseaseScoreTop Affiliating Genes
1pyogenic granuloma30.7LYVE1, PECAM1, TEK, ACTC1, SLC2A1, FLT4
2klippel-trenaunay syndrome30.6KRIT1, FLT4
3hemangioendothelioma30.6IFNA2, FLT4
4hemangioma, capillary infantile30.6FLT4, KDR
5cerebral cavernous malformation30.5PECAM1, KRIT1, KDR
6adenoma30.4FLT4, PRKG1, NKX2-1, SYP, MUC1, SLC2A1
7epithelioid hemangioendothelioma30.4IFNA2, FLT4
8angiosarcoma30.4KDR, MUC1, FLT4, ACTC1, TEK, PECAM1
9deficiency anemia30.2IFNA2
10adenocarcinoma30.1SFTPB, AR, FLT4, NKX2-1, SYP, SYNM
11arteriovenous malformation30.1SLC2A1, PECAM1
12kaposi's sarcoma30.1TEK, KDR, VEGFA, FLT4, IFNA2, PECAM1
13angiomyolipoma30.0ACTC1
14papillary carcinoma29.8NKX2-1, SYP, MUC1, SLC2A1, ACTC1
15thyroid cancer29.8NKX2-1, KDR, SLC2A1, TEK
16renal clear cell carcinoma29.8VEGFA, MUC1, KDR, SLC2A1
17hemangioma, capillary infantile, somatic29.8FLT4, KDR
18rhabdoid tumor29.8ACTC1, MUC1, SYP
19astrocytoma29.6SYP, VEGFA, KDR, SLC2A1, TEK
20colorectal cancer29.6KDR, VEGFA, NKX2-1, FLT4, IFNA2
21neuroendocrine carcinoma29.6MUC1, SYNM, SYP, NKX2-1
22inflammatory breast carcinoma29.6PROX1, TEK, LYVE1
23hepatitis c29.6IFNA2
24von hippel-lindau disease29.6VEGFA
25paraganglioma29.6SYP
26giant hemangioma10.9
27intramuscular hemangioma10.7
28pulmonary sclerosing hemangioma10.6
29venous hemangioma10.6
30histiocytoid hemangioma10.5
31weber syndrome10.5
32n syndrome10.4
33phace syndrome10.4
34glomeruloid hemangioma10.4
35thrombocytopenia10.4
36poems syndrome10.4
37sturge-weber syndrome10.4
38rapidly involuting congenital hemangioma10.4
39spindle cell hemangioma10.4
40hobnail hemangioma10.4
41gastric hemangioma10.4
42retinal cavernous hemangioma10.3
43hemangioma thrombocytopenia syndrome10.3
44cavernous malformation10.3
45bone epithelioid hemangioma10.3
46blue rubber bleb nevus syndrome10.3
47supraumbilical midabdominal raphe and facial cavernous hemangiomas10.3
48non-involuting congenital hemangioma10.3
49acquired hemangioma10.2
50familial hemangioma10.2

Graphical network of the top 20 diseases related to Hemangioma:



Diseases related to hemangioma

Clinical Features for Hemangioma

Drugs & Therapeutics for Hemangioma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Genetic Tests for Hemangioma

Anatomical Context for Hemangioma

Sources:
31LifeMap Discovery™
See all sources

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Hemangioma:
id TissueAnatomical CompartmentCell Relevance
1 HeartCardinal VeinsVenous Endothelial Cells Affected by disease

Animal Models for Hemangioma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Hemangioma

Sources:
51PubMed
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Articles related to Hemangioma:

(show top 50)    (show all 2073)
idTitleAuthorsYear
1
Rapid complete regression of an early infantile hemangioma with topical timolol gel. (24261914)
2014
2
Intra-abdominal (Type IV) sacrococcygeal teratoma presenting with buttock hemangioma. (24057924)
2013
3
I+6-integrin is required for the adhesion and vasculogenic potential of hemangioma stem cells. (24022922)
2013
4
Epithelioid hemangioma of the spine: a case series of six patients and review of the literature. (24045160)
2013
5
Elevated IGF2 prevents leptin induction and terminal adipocyte differentiation in hemangioma stem cells. (23047069)
2013
6
Pneumocytoma (formerly known as sclerosing hemangioma of the lung): a rare cause of chest pain. (23380035)
2013
7
Cavernous hemangioma of the testis mimicking a testicular teratoma. (23935725)
2013
8
Primary intraosseous hemangioma in the frontal bone. (23730614)
2013
9
Beta-blockers versus corticosteroids in the treatment of infantile hemangioma: an evidence-based systematic review. (23929254)
2013
10
Cavernous hemangioma of the external auditory canal. (23599093)
2013
11
Nasal cavity lobular capillary hemangioma due to insect sting. (22921301)
2012
12
Glomeruloid hemangiomas in the absence of POEMS syndrome. (22443389)
2012
13
Periocular epithelioid hemangioma: response to bevacizumab and vascular pathogenesis. (22965602)
2012
14
Epithelioid hemangioma-a rare scrotal tumor of childhood. (22698477)
2012
15
Airway hemangiomas in PHACE syndrome. (22865344)
2012
16
Microvenular hemangioma-an immunohistochemical study of 9 cases. (23169416)
2012
17
Capillary hemangioma in a rib presenting as large pleural effusion. (21440110)
2011
18
Vitreoretinal surgery for severe retinal capillary hemangiomas in von hippel-lindau disease. (20801520)
2011
19
Mesenteric cavernous hemangioma in a cryptorchid man. (21743240)
2011
20
Iris cavernous hemangioma :a case report. (21913353)
2011
21
Extradural cavernous hemangioma of thoracic spine. (21877050)
2011
22
Pulmonary sclerosing hemangioma in a 21-year-old male with metastatic hereditary non-polyposis colorectal cancer: report of a case. (21645337)
2011
23
Dental caries as a side effect of infantile hemangioma treatment with propranolol solution. (21510011)
2010
24
POEMS syndrome with an isolated lytic lesion and glomeruloid hemangiomas: report of one case]. (19701559)
2009
25
A rare vascular tumor of the external auditory canal: the capillary hemangioma. (19860637)
2009
26
Differential expression of SKI oncogene protein in hemangiomas. (19643254)
2009
27
Adult onset flatfoot associated with an intramuscular hemangioma of the posterior tibialis muscle. (19292229)
2008
28
Expression and significance of Ang1, Ang2 and receptor Tie2 in hemangioma]. (18269030)
2007
29
Two infants with life-threatening diffuse neonatal hemangiomatosis treated with cyclophosphamide. (16369922)
2006
30
Pure epidural cavernous hemangioma of the cervical spine that presented with an acute sensory deficit caused by hemorrhage. (17191320)
2006
31
Morphologic, phenotypic and functional characteristics of endothelial cells derived from human hepatic cavernous hemangioma. (17008795)
2006
32
Cavernous hemangioma of the urinary bladder in an 8-year-old child. (15157217)
2004
33
Rare case of intramasseteric cavernous hemangioma in a three-year-old boy: a diagnostic dilemma. (15224828)
2004
34
Cavernous hemangioma of the foot and antecubital fossa: an alternative therapeutic option. (12652506)
2003
35
A case of headache and disordered vision: cavernous hemangioma of the optic chiasm (2003:8b). (14631971)
2003
36
Dorsal foramenal extraosseous epidural cavernous hemangioma. (14520522)
2003
37
Cavernous hemangioma arising from the lesser omentum: MR findings. (10931994)
2000
38
Diffuse neonatal hemangiomatosis with extensive involvement of the brain and cervical spinal cord. (10369901)
1999
39
Cavernous hemangioma presenting as a renal hilar mass. (9817341)
1998
40
Induction of apoptosis in human dermal microvascular endothelial cells and infantile hemangiomas by interferon-alpha. (9831809)
1998
41
Juvenile hemangioma of the testis: analysis of expression of angiogenic factors. (9037300)
1997
42
Epidermal nevus syndrome with hemangioma simplex. (9046747)
1997
43
Aneurysm of the transverse cervical artery occurring in association with a cavernous hemangioma as a complication of Klippel-TrAcnaunay syndrome: report of a case. (8640026)
1995
44
Hobnail hemangioma. (8520065)
1995
45
Pathologic quiz case 2. Intramuscular capillary hemangioma. (3790291)
1987
46
Diffuse neonatal hemangiomatosis. (3952031)
1986
47
Capillary hemangioma of the optic disc. (6238051)
1984
48
The air meniscus sign in sclerosing hemangioma of the lung. (208101)
1978
49
Intramuscular hemangioma in the head and neck. (1139430)
1975
50
PRESSURE IN THE TREATMENT OF GIANT HEMANGIOMA WITH PURPURA. CASE REPORT AND OBSERVATIONS. (14245719)
1964

Genetic Variations for Hemangioma

Expression for genes affiliated with Hemangioma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Hemangioma

Search GEO for disease gene expression data for Hemangioma.

Pathways for genes affiliated with Hemangioma

Sources:
30KEGG, 4Cell Signaling Technology, 53R&D Systems, 50PharmGKB, 56SinoBiological, 52QIAGEN, 12EMD Millipore, 38NCBI BioSystems Database, 54Reactome
See all sources

Compounds for genes affiliated with Hemangioma

Sources:
45Novoseek, 24HMDB, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 50PharmGKB, 2BitterDB
See all sources

Compounds related to Hemangioma according to GeneCards/GeneDecks:

(show top 50)    (show all 73)
idCompoundScoreTop Affiliating Genes
1vegf4511.6SFTPB, IFNA2, LYVE1, PECAM1, TEK, ACTC1
2tyrosine4511.6SYP, NKX2-1, PRKG1, FLT4, IFNA2, SFTPB
3paraffin4511.6SFTPB, LYVE1, PECAM1, TEK, ACTC1, SLC2A1
4retinoic acid45 2412.4SFTPB, IFNA2, AR, FLT4, NKX2-1, SYP
5matrigel4511.3AR, FLT4, VEGFA, MUC1, KDR, ACTC1
6cysteine4511.3SFTPB, IFNA2, SYP, MUC1, KDR, SLC2A1
7ribonucleic acid4511.3SFTPB, IFNA2, NKX2-1, MUC1, SLC2A1, ACTC1
8thymidine45 2412.3SFTPB, IFNA2, PRKG1, MUC1, KDR, TEK
9progesterone45 60 29 11 2415.3SFTPB, IFNA2, AR, NKX2-1, SYP, MUC1
10serine4511.3SFTPB, PRKG1, NKX2-1, SYP, SLC2A1, KRIT1
11dexamethasone45 50 29 1114.3SFTPB, AR, NKX2-1, VEGFA, KDR, SLC2A1
12nitric oxide45 11 2413.2SFTPB, PRKG1, SYP, MUC1, KDR, KRIT1
13oxygen45 2412.2SFTPB, FLT4, PRKG1, MUC1, SLC2A1, TEK
14actinomycin d4511.2SFTPB, AR, VEGFA, MUC1, SLC2A1, KRIT1
15formaldehyde45 2412.2NKX2-1, SYP, MUC1, KRIT1, ACTC1, PECAM1
16agar4511.2IFNA2, AR, MUC1, KDR, SLC2A1, PECAM1
17tamoxifen45 50 29 1114.2IFNA2, AR, VEGFA, MUC1, KDR, KRIT1
18testosterone45 60 11 2414.2AR, PRKG1, SYP, MUC1, KRIT1, ACTC1
19rapamycin4511.1AR, FLT4, VEGFA, KDR, SLC2A1, PECAM1
20hematoxylin4511.1NKX2-1, SYP, MUC1, ACTC1, PECAM1
21genistein45 29 60 2 11 2416.1AR, SYP, VEGFA, KDR, SLC2A1, KRIT1
222,4-dinitrophenol4511.1SFTPB, AR, NKX2-1, SLC2A1
23mucicarmine4511.1NKX2-1, SYP, MUC1, ACTC1
24threonine4511.1SFTPB, PRKG1, NKX2-1, MUC1, KRIT1, TEK
25gold4511.1SFTPB, IFNA2, SYP, MUC1, KRIT1
26cisplatin45 50 60 1114.1IFNA2, SYP, VEGFA, MUC1, KDR, SLC2A1
27b 7234511.1NKX2-1, SYP, MUC1, ACTC1
28azd 21714511.0FLT4, VEGFA, KDR
29chloramphenicol45 2 1113.0SFTPB, AR, PRKG1, MUC1, LYVE1
30zd64744511.0KDR, VEGFA, FLT4
31cyclic amp45 2412.0SFTPB, NKX2-1, SYP, MUC1, KRIT1, TEK
32axitinib45 60 1113.0FLT4, VEGFA, KDR
33s 1004511.0ACTC1, MUC1, SYP
34progestin4511.0AR, VEGFA, MUC1, KDR
35su54164511.0KDR, VEGFA, FLT4
36reticulin4511.0SYP, MUC1, ACTC1
375fluorouracil4511.0SLC2A1, MUC1, IFNA2
38geldanamycin45 50 60 1114.0AR, VEGFA, KDR, KRIT1
39Regorafenib1110.9TEK, KDR, FLT4
40sunitinib45 50 1112.9FLT4, VEGFA, KDR
41vegfe2910.8FLT4, KDR
42ly2940024510.8AR, FLT4, VEGFA, KDR, SLC2A1
43vegfc2910.8FLT4, KDR
44glucose4510.8IFNA2, PRKG1, MUC1, SLC2A1, ACTC1, LYVE1
45linuron4510.7AR, LYVE1
46procymidone4510.7AR, LYVE1
47polyglycine4510.7LYVE1, AR
48leucovorin45 50 1112.6KDR, VEGFA, IFNA2
49glycogen45 2411.6PRKG1, SYP, MUC1, SLC2A1, ACTC1
50steroid4510.5IFNA2, AR, NKX2-1, SYP, ACTC1, LYVE1

GO Terms for genes affiliated with Hemangioma

Sources:
16Gene Ontology
See all sources

Cellular components related to Hemangioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell-cell junctionGO:00591110.6TEK, KRIT1, SLC2A1
2extracellular regionGO:00557610.5TEK, SFTPA1, IFNA2, FLT4, VEGFA, MUC1

Biological processes related to Hemangioma according to GeneCards/GeneDecks:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of endothelial cell migrationGO:01059511.1TEK, KDR, VEGFA, PROX1, FLT4
2positive regulation of endothelial cell proliferationGO:00193811.1FLT4, PROX1, VEGFA, KDR, TEK
3positive regulation of cell proliferationGO:00828411.0AR, FLT4, PROX1, VEGFA, KDR
4positive regulation of protein phosphorylationGO:00193411.0TEK, KDR, VEGFA, FLT4
5positive regulation of focal adhesion assemblyGO:05189411.0TEK, KDR, VEGFA
6negative regulation of endothelial cell apoptotic processGO:200035211.0TEK, KRIT1, KDR
7cellular response to vascular endothelial growth factor stimulusGO:03592411.0FLT4, VEGFA, KDR
8vascular endothelial growth factor receptor signaling pathwayGO:04801011.0KDR, VEGFA, FLT4
9blood coagulationGO:00759611.0IFNA2, PRKG1, VEGFA, TEK, PECAM1
10angiogenesisGO:00152511.0TEK, KRIT1, KDR, VEGFA
11peptidyl-tyrosine phosphorylationGO:01810810.9TEK, KDR, FLT4
12transmembrane receptor protein tyrosine kinase signaling pathwayGO:00716910.9FLT4, KDR, TEK
13positive regulation of MAPK cascadeGO:04341010.9AR, FLT4, KDR
14skeletal muscle thin filament assemblyGO:03024010.9PROX1, ACTC1
15positive regulation of intracellular protein kinase cascadeGO:01074010.8TEK, VEGFA
16lymph vessel developmentGO:00194510.8KDR, FLT4
17positive regulation of protein kinase C signaling cascadeGO:09003710.8VEGFA, FLT4
18positive regulation of positive chemotaxisGO:05092710.8VEGFA, KDR
19lung developmentGO:03032410.7VEGFA, NKX2-1, PROX1
20surfactant homeostasisGO:04312910.7VEGFA, KDR
21lymphangiogenesisGO:00194610.6FLT4, PROX1
22positive regulation of angiogenesisGO:04576610.6VEGFA, KDR, TEK
23mammary gland alveolus developmentGO:06074910.6VEGFA, AR
24positive regulation of ERK1 and ERK2 cascadeGO:07037410.5TEK, KDR, FLT4
25cell migration involved in sprouting angiogenesisGO:00204210.3KDR, VEGFA

Molecular functions related to Hemangioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551511.0PECAM1, IFNA2, AR, FLT4, PROX1, PRKG1
2vascular endothelial growth factor-activated receptor activityGO:00502110.6KDR, FLT4
3transmembrane receptor protein tyrosine kinase activityGO:00471410.3TEK, KDR, FLT4

Products for genes affiliated with Hemangioma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hemangioma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet