MCID: HMN010
MIFTS: 70

Hemangioma malady

Genetic diseases, Rare diseases, Cancer diseases categories
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Summaries for Hemangioma

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Sources:
8Disease Ontology, 65Wikipedia, 33MalaCards
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Disease Ontology:8 A cell type benign neoplasm that has physical basis in endothelial cells that line blood vessels and is characterised by increased number of normal or abnormal vessels filled with blood.

MalaCards: Hemangioma is related to cavernous hemangioma and capillary hemangioma. An important gene associated with Hemangioma is KDR (kinase insert domain receptor (a type III receptor tyrosine kinase)), and among its related pathways are Signaling events mediated by TCPTP and Akt Signaling Pathway. The drugs interferon alfa-2a and interferon alfa-2b and the compounds vegfe and vegfc have been mentioned in the context of this disorder. Affiliated tissues include endothelial, liver and lung, and related mouse phenotypes are no phenotypic analysis and liver/biliary system.

Wikipedia:65 A hemangioma is a benign and usually self-involuting tumor (swelling or growth) of the endothelial cells... more...

Aliases & Classifications for Hemangioma

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8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 62UMLS, 35MeSH, 58SNOMED-CT, 27ICD9CM, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases, Cancer diseases


Aliases & Descriptions:

hemangioma 8 43 10 45 62


Related Diseases for Hemangioma

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Hemangioma family:

Acquired Hemangioma Hemangioma, Hereditary
Familial Hemangioma

Diseases related to Hemangioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 514)
idRelated DiseaseScoreTop Affiliating Genes
1cavernous hemangioma31.9KRIT1
2capillary hemangioma31.7SLC2A1
3sclerosing hemangioma31.5SFTPB
4hepatitis31.0KRIT1, IFNA2, PRKG1
5hemangioendothelioma30.7FLT4, IFNA2
6pyogenic granuloma30.7SLC2A1, TEK, FLT4, ACTC1
7klippel-trenaunay syndrome30.7FLT4, KRIT1
8epithelioid hemangioendothelioma30.6FLT4, IFNA2
9cerebral cavernous malformation30.5KRIT1, KDR
10hemangioma, capillary infantile30.5FLT4, KDR
11angiosarcoma30.4TEK, KDR, FLT4, MUC1, ACTC1
12lymphangioma30.4FLT4, ACTC1
13meningioma30.3SLC2A1, MUC1
14teratoma30.2NKX2-1, ACTC1
15hemangioblastoma30.1VEGFA, KDR, MUC1, SLC2A1
16adenoma30.1FLT4, MUC1, PRKG1, ACTC1, NKX2-1, SLC2A1
17glomus tumor30.1ACTC1
18melanoma30.0TEK, VEGFA, KDR, FLT4, IFNA2, ACTC1
19kaposi's sarcoma30.0TEK, VEGFA, KDR, FLT4, IFNA2
20sarcoma30.0KDR, FLT4, MUC1, PRKG1, ACTC1, AR
21papilloma30.0IFNA2, FLT4
22hypothyroidism30.0NKX2-1, IFNA2
23rhabdoid tumor30.0MUC1, ACTC1
24giant cell tumor30.0MUC1, ACTC1
25thyroid cancer29.9TEK, KDR, NKX2-1, SLC2A1
26papillary carcinoma29.9SLC2A1, NKX2-1, ACTC1, MUC1
27hepatocellular carcinoma29.9TEK, VEGFA, KDR, PRKG1, IFNA2, NKX2-1
28adenocarcinoma29.9TEK, SFTPB, VEGFA, KDR, FLT4, MUC1
29papillary adenocarcinoma29.7MUC1, NKX2-1, SLC2A1
30astrocytoma29.7TEK, VEGFA, KDR, SLC2A1
31neuroendocrine carcinoma29.7MUC1, NKX2-1
32lung cancer29.7VEGFA, MUC1, NKX2-1
33colorectal cancer29.6VEGFA, KDR, FLT4, IFNA2, NKX2-1
34breast cancer29.6TEK, VEGFA, KDR, FLT4, MUC1, KRIT1
35non-small cell lung carcinoma29.6TEK, VEGFA, KDR, FLT4, NKX2-1, SLC2A1
36leukemia29.5TEK, KDR, FLT4, PRKG1, IFNA2, KRIT1
37giant hemangioma10.7
38intramuscular hemangioma10.7
39pulmonary sclerosing hemangioma10.6
40endotheliitis10.6
41retinitis10.6
42venous hemangioma10.5
43choroiditis10.5
44histiocytoid hemangioma10.5
45weber syndrome10.5
46phace syndrome10.5
47glomeruloid hemangioma10.4
48thrombocytopenia10.4
49poems syndrome10.4
50hobnail hemangioma10.4

Graphical network of the top 20 diseases related to Hemangioma:



Diseases related to hemangioma

Symptoms for Hemangioma

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Drugs & Therapeutics for Hemangioma

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Genetic Tests for Hemangioma

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Anatomical Context for Hemangioma

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Sources:
31LifeMap Discovery™, 33MalaCards
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MalaCards organs/tissues related to Hemangioma:

33
Endothelial, Liver, Lung, Bone, Skin, Breast, Colon, Thyroid, Spinal cord, Kidney, Testis, Spleen, Cervix, Small intestine, Tongue, Brain, Heart, Retina, Lymph node, Uterus, B cells, Placenta, Eye, Adrenal gland, Thymus, Trachea, Pituitary, Testes, Thalamus, Fetal liver, Fetal lung, Appendix, Smooth muscle, Monocytes, Skeletal muscle, Tonsil, Adipocyte, Pancreas, Prostate, Salivary gland, Ovary, Myeloid

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Hemangioma:
id TissueAnatomical CompartmentCell Relevance
1 HeartCardinal VeinsVenous Endothelial Cells Affected by disease

Animal Models for Hemangioma or affiliated genes

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37MGI
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Publications for Hemangioma

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52PubMed
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Articles related to Hemangioma:

(show top 50)    (show all 1946)
idTitleAuthorsYear
1
Three-dimensional stereophotogrammetry: a novel method in volumetric measurement of infantile hemangioma. (24106998)
2014
2
Mediastinal hemangioma: Masquerading as pleural effusion. (24347874)
2013
3
Dubin-Johnson syndrome with multiple liver cavernous hemangiomas: report of a familial case. (24228133)
2013
4
Segmental ulcerated perineal hemangioma of infancy: a complex case of PELVIS syndrome successfully treated using a multidisciplinary approach. (23278237)
2013
5
Malignant Differential Diagnosis in Children Referred for Infantile Hemangioma. (23903077)
2013
6
Cavernous sinus but not intrasellar cavernous hemangioma. (24005750)
2013
7
Nasal lobular capillary hemangioma. (24228209)
2013
8
Rapidly Involuting Congenital Hemangioma Associated with Profound, Transient Thrombocytopenia. (22937785)
2012
9
Editorial comment to a case of large bladder hemangioma successfully treated with endoscopic yttrium aluminium garnet laser irradiation. (22211454)
2012
10
Nasal cavity lobular capillary hemangioma due to insect sting. (22921301)
2012
11
Myometrial cavernous hemangioma with pulmonary thromboembolism in a post-partum woman: a case report and review of the literature. (23176111)
2012
12
Evolution of hemangioma endothelium. (22565125)
2012
13
Spinal epidural arteriovenous hemangioma mimicking lumbar disc herniation. (23133733)
2012
14
Hepatic angiomyolipoma with a giant hemangioma. (22041879)
2011
15
Lobular capillary hemangioma in the soft tissue of the finger: sonographic findings. (20428860)
2010
16
Soluble receptors for vascular endothelial growth factor (sVEGFR1/sVEGFR2) in infantile hemangioma. (20854187)
2010
17
Cavernous hemangioma presenting as a giant cervical mass: a case report. (20066626)
2010
18
Cavernous sinus cavernous hemangioma largely extending into the sella turcica and mimicking pituitary adenoma: case report. (20448429)
2010
19
A giant scrotal cavernous hemangioma extending to the penis and perineum: a case report. (19767262)
2009
20
Spinal radiosurgical treatment for thoracic epidural cavernous hemangioma presenting as radiculomyelopathy: technical case report. (19487867)
2009
21
Use of thalidomide to diminish growth velocity in a life-threatening congenital intracranial hemangioma. (18671617)
2008
22
Adult onset flatfoot associated with an intramuscular hemangioma of the posterior tibialis muscle. (19292229)
2008
23
Electroconvulsive therapy in a patient with a cavernous hemangioma. (18562947)
2008
24
Atrial hemangioma: a rare cause of hydrops fetalis and intrauterine fetal death. (16621228)
2007
25
The expression and role of glucose transporter-1 in infantile hemangioma]. (17554865)
2007
26
Management of urethral hemangiomas associated with Klippel-Trenaunay-Weber syndrome by endoscopic sclerotherapy. (17645615)
2007
27
Intramuscular cavernous hemangioma arising from masseter muscle: a diagnostic dilemma (2006: 12b). (17225132)
2007
28
Blue rubber bleb nevus syndrome: Report of a patient with hemangiomas of the vaginal portion of the cervix appearing during pregnancy. (17688627)
2007
29
Venous hemangioma arising from the diaphragm: a case report of computed tomography and magnetic resonance imaging findings. (16915071)
2006
30
Spontaneous hemopneumothorax as a result of venous hemangioma: a unique case? (16572882)
2006
31
Spindle cell hemangioma and epithelioid hemangioendothelioma arising in an area of lymphedema. (16778491)
2006
32
Ahmed glaucoma valve implant for childhood glaucoma in Sturge-Weber syndrome with choroidal hemangioma. (17214399)
2006
33
Intravenous pyogenic granuloma or intravenous lobular capillary hemangioma. (15565332)
2005
34
Surgical treatment of a huge cavernous hemangioma surrounding the right coronary artery. (15854977)
2005
35
Hemoperitoneum from a spontaneous rupture of a giant hemangioma of the liver: report of a case. (12768374)
2003
36
Unilateral progressive multiple sclerosing hemangioma in a young female successfully treated by pneumonectomy: report of a case. (12222919)
2002
37
Clusterin/apoJ expression during the development of hemangioma. (10872662)
2000
38
Posterior mediastinal capillary hemangioma with extradural extension resembling neuroblastoma. (10398787)
1999
39
Pedunculated giant hemangioma of liver. (9167384)
1997
40
Successful treatment of infantile hemangiomas with interferon-alpha-2b. (9201147)
1997
41
Distinguishing small hepatic hemangiomas from vascular liver metastases in gastrinoma: use of a somatostatin-receptor scintigraphic agent. (8988205)
1997
42
Juvenile hemangioma of the testis: analysis of expression of angiogenic factors. (9037300)
1997
43
Capillary hemangioma--report of a case. (9522754)
1996
44
Aneurysm of the transverse cervical artery occurring in association with a cavernous hemangioma as a complication of Klippel-TrAcnaunay syndrome: report of a case. (8640026)
1995
45
A benign neuroendocrine tumor of the lung: study on the origin of the so-called sclerosing hemangioma of the lung]. (8082241)
1994
46
Gastric hemangioma associated with phleboliths. (3972216)
1985
47
Histiocytoid hemangioma with features of angiolymphoid hyperplasia and Kaposi's sarcoma. A study by light microscopy, electron microscopy, and immunologic techniques. (6230021)
1983
48
Histiocytoid hemangioma of the skin and scapula. A case report with electron microscopy and immunohistochemistry. (6403216)
1983
49
Radionuclide and CT diagnosis: cavernous hemangioma of liver. (6250385)
1980
50
Non-neoplastic sclerotic pulmonary lesion (sclerosing hemangioma). Report of a case. (4331028)
1971

Variations for Hemangioma

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Expression for genes affiliated with Hemangioma

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hemangioma

Search GEO for disease gene expression data for Hemangioma.

Pathways for genes affiliated with Hemangioma

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Sources:
50PathCards, 38NCBI BioSystems Database, 54R&D Systems, 5Cell Signaling Technology, 55Reactome, 61Tocris Bioscience, 53QIAGEN, 60Thomson Reuters, 51PharmGKB, 57SinoBiological, 30KEGG
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Pathways related to Hemangioma according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9KDR, VEGFA
29.7FLT4, KDR, TEK
39.7TEK, KDR, FLT4
49.7TEK, KDR, FLT4
5
Show member pathways
9.6FLT4, KDR, VEGFA
6
Show member pathways
9.6FLT4, KDR, VEGFA
7
Show member pathways
9.6FLT4, KDR, VEGFA
8
Show member pathways
VEGFR1 specific signals38
9.6FLT4, KDR, VEGFA
9
Show member pathways
Angiogenesis38
9.6TEK, VEGFA, KDR
109.5VEGFA, KDR, SLC2A1
119.4SLC2A1, VEGFA, TEK
12
Show member pathways
9.3TEK, KDR, FLT4, SLC2A1
13
Show member pathways
9.2TEK, KDR, FLT4, IFNA2
14
Show member pathways
9.0TEK, KDR, FLT4, AR
158.9IFNA2, FLT4, KDR, VEGFA, TEK
16
Show member pathways
8.9TEK, VEGFA, KDR, FLT4, IFNA2
17
Show member pathways
8.9KRIT1, FLT4, KDR, VEGFA, TEK
18
Show member pathways
8.8PRKG1, FLT4, KDR, TEK
19
Show member pathways
8.6TEK, VEGFA, PRKG1, IFNA2

Compounds for genes affiliated with Hemangioma

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Sources:
29IUPHAR, 45Novoseek, 61Tocris Bioscience, 11DrugBank, 51PharmGKB, 24HMDB, 3BitterDB
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Compounds related to Hemangioma according to GeneCards/GeneDecks:

(show top 50)    (show all 90)
idCompoundScoreTop Affiliating Genes
1vegfe2910.3KDR, FLT4
2vegfc2910.2KDR, FLT4
3azd 21714510.1VEGFA, KDR, FLT4
4zd64744510.0FLT4, KDR, VEGFA
5axitinib61 45 1112.0FLT4, KDR, VEGFA
6su54164510.0VEGFA, KDR, FLT4
7sunitinib45 51 1112.0VEGFA, KDR, FLT4
8vandetanib51 1111.0KDR, VEGFA, TEK
9ptk787459.9KDR, VEGFA
10sorafenib45 51 1111.8VEGFA, KDR, FLT4
11mucicarmine459.8MUC1, ACTC1, NKX2-1
12regorafenib51 1110.7TEK, VEGFA, KDR, FLT4
13b 723459.7NKX2-1, ACTC1, MUC1
14leucovorin45 51 1111.7IFNA2, KDR, VEGFA
15su6668459.6KDR, VEGFA
16infliximab45 51 1111.5IFNA2, VEGFA, TEK
17trastuzumab45 51 1111.4VEGFA, KDR, MUC1
182,4-dinitrophenol459.3AR, SLC2A1, NKX2-1, SFTPB
19hematoxylin459.3NKX2-1, ACTC1, MUC1
20formaldehyde45 2410.3MUC1, ACTC1, NKX2-1, KRIT1
21geldanamycin45 51 61 1112.2AR, KRIT1, KDR, VEGFA
22gold459.1KRIT1, IFNA2, MUC1, SFTPB
23progestin459.1AR, MUC1, KDR, VEGFA
24rapamycin459.0VEGFA, KDR, FLT4, SLC2A1, AR
25ly294002459.0AR, SLC2A1, FLT4, KDR, VEGFA
265fluorouracil459.0VEGFA, KDR, MUC1, IFNA2, SLC2A1
27cisplatin45 51 61 1111.8SLC2A1, IFNA2, MUC1, KDR, VEGFA
28ascorbic acid45 249.8AR, SLC2A1, IFNA2, SFTPB
29cyclic amp45 249.8TEK, SFTPB, MUC1, NKX2-1, KRIT1
30genistein45 29 61 3 24 1113.8VEGFA, KDR, KRIT1, SLC2A1, AR
31progesterone45 29 61 24 1112.7AR, ACTC1, IFNA2, MUC1, SFTPB
32agar458.7KDR, MUC1, IFNA2, SLC2A1, AR
33ribonucleic acid458.4TEK, SFTPB, MUC1, IFNA2, ACTC1, NKX2-1
34chloramphenicol45 3 51 1111.4SFTPB, MUC1, PRKG1, AR
35matrigel458.3TEK, VEGFA, KDR, FLT4, MUC1, ACTC1
36tamoxifen45 51 29 1111.3VEGFA, KDR, MUC1, IFNA2, KRIT1, AR
37actinomycin d458.3SFTPB, VEGFA, MUC1, KRIT1, SLC2A1, AR
38thymidine45 249.3TEK, SFTPB, KDR, MUC1, PRKG1, IFNA2
39cysteine458.2TEK, SFTPB, KDR, MUC1, IFNA2, KRIT1
40nitric oxide45 24 1110.1TEK, SFTPB, KDR, MUC1, PRKG1, KRIT1
41threonine458.1TEK, SFTPB, MUC1, PRKG1, NKX2-1, KRIT1
42retinoic acid45 249.0SFTPB, KDR, FLT4, MUC1, IFNA2, ACTC1
43testosterone45 61 24 1110.9MUC1, PRKG1, ACTC1, KRIT1, AR
44oxygen45 248.6TEK, SFTPB, FLT4, MUC1, PRKG1, IFNA2
45paraffin457.4SLC2A1, NKX2-1, ACTC1, MUC1, FLT4, KDR
46dexamethasone45 51 29 1110.3FLT4, KDR, VEGFA, SFTPB, MUC1, ACTC1
47serine456.9TEK, SFTPB, KDR, MUC1, PRKG1, NKX2-1
48vegf456.4AR, TEK, SLC2A1, ACTC1, IFNA2, PRKG1
49estrogen456.3VEGFA, KDR, FLT4, MUC1, PRKG1, IFNA2
50tyrosine456.3FLT4, KDR, VEGFA, SFTPB, TEK, MUC1

GO Terms for genes affiliated with Hemangioma

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16Gene Ontology
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Cellular components related to Hemangioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1actin filamentGO:0058849.9ACTC1, TEK
2cell-cell junctionGO:0059119.2TEK, KRIT1, SLC2A1
3extracellular regionGO:0055768.4TEK, SFTPA1, VEGFA, KDR, FLT4, IFNA2
4extracellular spaceGO:0056158.2KRIT1, ACTC1, IFNA2, VEGFA, SFTPA1, SFTPB
5cytoplasmGO:0057376.6TEK, VEGFA, FLT4, MUC1, PRKG1, ACTC1

Biological processes related to Hemangioma according to GeneCards/GeneDecks:

(show all 30)
idNameGO IDScoreTop Affiliating Genes
1lymph vessel developmentGO:00194510.3KDR, FLT4
2positive regulation of protein kinase C signalingGO:09003710.2VEGFA, FLT4
3surfactant homeostasisGO:04312910.2VEGFA, KDR
4positive regulation of positive chemotaxisGO:05092710.2KDR, VEGFA
5positive regulation of intracellular signal transductionGO:190253310.1VEGFA, TEK
6cell migration involved in sprouting angiogenesisGO:00204210.1KDR, VEGFA
7sprouting angiogenesisGO:00204010.1FLT4, TEK
8branching morphogenesis of an epithelial tubeGO:04875410.0KDR, VEGFA
9cellular response to vascular endothelial growth factor stimulusGO:03592410.0FLT4, KDR, VEGFA
10transmembrane receptor protein tyrosine kinase signaling pathwayGO:00716910.0TEK, KDR, FLT4
11vascular endothelial growth factor receptor signaling pathwayGO:04801010.0VEGFA, KDR, FLT4
12peptidyl-tyrosine phosphorylationGO:01810810.0TEK, KDR, FLT4
13positive regulation of ERK1 and ERK2 cascadeGO:07037410.0FLT4, KDR, TEK
14positive regulation of focal adhesion assemblyGO:0518949.9TEK, VEGFA, KDR
15positive regulation of mesenchymal cell proliferationGO:0020539.9KDR, VEGFA
16positive regulation of angiogenesisGO:0457669.9TEK, VEGFA, KDR
17protein autophosphorylationGO:0467779.9TEK, KDR, FLT4
18negative regulation of endothelial cell apoptotic processGO:20003529.8KRIT1, KDR, TEK
19cell maturationGO:0484699.8KDR, VEGFA
20respiratory gaseous exchangeGO:0075859.7SFTPB, SFTPA1
21positive regulation of endothelial cell migrationGO:0105959.7FLT4, KDR, VEGFA, TEK
22positive regulation of endothelial cell proliferationGO:0019389.7TEK, VEGFA, KDR, FLT4
23positive regulation of protein phosphorylationGO:0019349.7FLT4, KDR, VEGFA, TEK
24ovarian follicle developmentGO:0015419.6KDR, VEGFA
25protein oligomerizationGO:0512599.5AR, TEK
26angiogenesisGO:0015259.5KRIT1, KDR, VEGFA, TEK
27negative regulation of apoptotic processGO:0430669.4TEK, VEGFA, KDR, FLT4, ACTC1
28positive regulation of cell proliferationGO:0082849.3VEGFA, KDR, FLT4, AR
29cell-cell signalingGO:0072679.2AR, IFNA2, TEK
30blood coagulationGO:0075968.8IFNA2, PRKG1, VEGFA, TEK

Molecular functions related to Hemangioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor bindingGO:0198389.7FLT4, KDR, TEK
2vascular endothelial growth factor-activated receptor activityGO:0050219.7FLT4, KDR
3transmembrane receptor protein tyrosine kinase activityGO:0047149.6TEK, KDR, FLT4
4ATP bindingGO:0055248.6ACTC1, PRKG1, FLT4, KDR, TEK
5protein bindingGO:0055155.8TEK, VEGFA, KDR, FLT4, MUC1, PRKG1

Products for genes affiliated with Hemangioma

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Sources for Hemangioma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet