MCID: HMN010
MIFTS: 59

Hemangioma malady

Categories: Cancer diseases, Genetic diseases

Aliases & Classifications for Hemangioma

Summaries for Hemangioma

Disease Ontology : 12 A cell type benign neoplasm that has physical basis in endothelial cells that line blood vessels and is characterised by increased number of normal or abnormal vessels filled with blood.

MalaCards based summary : Hemangioma is related to cavernous hemangioma of face and meige syndrome. An important gene associated with Hemangioma is KDR (Kinase Insert Domain Receptor), and among its related pathways/superpathways are PAK Pathway and Ras signaling pathway. The drugs Parecoxib and Sufentanil have been mentioned in the context of this disorder. Affiliated tissues include Heart, endothelial and liver, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 71 An infantile hemangioma (IH) is one of the most common benign tumors of infancy and occurs in... more...

Related Diseases for Hemangioma

Diseases in the Hemangioma family:

Acquired Hemangioma Hemangioma, Hereditary
Familial Hemangioma

Diseases related to Hemangioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 492)
id Related Disease Score Top Affiliating Genes
1 cavernous hemangioma of face 32.6 CHGA NKX2-1 SFTPB SYP
2 meige syndrome 29.6 CHGA NKX2-1 SYP
3 intrahepatic cholangiocarcinoma 29.2 LYVE1 PDPN PROX1
4 hemolytic anemia 26.4 ACTC1 ANGPT1 ANGPT2 CD34 CHGA DIO3
5 capillary hemangioma 12.2
6 cavernous hemangioma 12.2
7 non-involuting congenital hemangioma 12.1
8 hemangioma, capillary infantile 12.1
9 hemangioma-thrombocytopenia syndrome 12.1
10 sclerosing hemangioma 12.1
11 rapidly involuting congenital hemangioma 12.0
12 glomeruloid hemangioma 12.0
13 intramuscular hemangioma 11.9
14 pulmonary sclerosing hemangioma 11.8
15 giant hemangioma 11.8
16 spindle cell hemangioma 11.8
17 histiocytoid hemangioma 11.8
18 skin hemangioma 11.8
19 hemangioma of liver 11.8
20 venous hemangioma 11.8
21 hemangioma of spleen 11.8
22 hobnail hemangioma 11.8
23 gastric hemangioma 11.8
24 hemangioma of lung 11.8
25 acquired hemangioma 11.8
26 supraumbilical midabdominal raphe and facial cavernous hemangiomas 11.8
27 verrucous hemangioma 11.8
28 breast hemangioma 11.8
29 bone epithelioid hemangioma 11.8
30 diffuse cavernous hemangioma of the rectum 11.7
31 hemangioma of orbit 11.7
32 cavernous hemangioma of orbit 11.7
33 hemangioma, hereditary 11.7
34 intracranial structure hemangioma 11.7
35 central nervous system hemangioma 11.7
36 hemangioma of intra-abdominal structure 11.7
37 skin epithelioid hemangioma 11.7
38 breast epithelioid hemangioma 11.7
39 hemangioma of subcutaneous tissue 11.7
40 cavernous hemangioma of colon 11.7
41 breast capillary hemangioma 11.6
42 hemangioma, capillary infantile susceptibility 11.6
43 hemangiomas, cavernous, of face and supraumbilical midline raphe 11.6
44 sacral hemangiomas multiple congenital abnormalities 11.6
45 verrucous keratotic hemangioma 11.6
46 pyogenic granuloma 11.6
47 cerebral cavernous malformations-1 11.6
48 partially involuting congenital hemangioma 11.6
49 transverse limb deficiency hemangioma 11.6
50 hemangioma of peripheral nerve 11.6

Graphical network of the top 20 diseases related to Hemangioma:



Diseases related to Hemangioma

Symptoms & Phenotypes for Hemangioma

MGI Mouse Phenotypes related to Hemangioma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.33 ACTC1 ANGPT1 ANGPT2 CHGA FGF2 FLT4
2 homeostasis/metabolism MP:0005376 10.25 CHGA DIO3 FGF2 FLT4 KDR NKX2-1
3 cellular MP:0005384 10.21 ACTC1 ANGPT2 CD34 DIO3 FGF2 KDR
4 growth/size/body region MP:0005378 10.18 ACTC1 ANGPT1 CHGA DIO3 FLT4 KDR
5 mortality/aging MP:0010768 10.16 ACTC1 ANGPT1 ANGPT2 CHGA DIO3 FGF2
6 digestive/alimentary MP:0005381 9.95 ANGPT2 FLT4 NKX2-1 PDPN PECAM1 PROX1
7 muscle MP:0005369 9.85 TEK VEGFA ACTC1 ANGPT1 FGF2 FLT4
8 respiratory system MP:0005388 9.56 KDR NKX2-1 PDPN PECAM1 PROX1 SFTPB
9 vision/eye MP:0005391 9.23 ANGPT1 ANGPT2 FGF2 KDR KRIT1 PROX1

Drugs & Therapeutics for Hemangioma

Drugs for Hemangioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 196)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Parecoxib Approved Phase 4 198470-84-7
2
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
3
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 83-43-2 6741
4
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-24-8 5755
5
Propranolol Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 525-66-6 4946
6
Dexmedetomidine Approved, Vet_approved Phase 4 76631-46-4, 113775-47-6 68602 5311068 56032
7
Ethiodized oil Approved Phase 4 8008-53-5
8 Adjuvants, Anesthesia Phase 4
9 Analgesics Phase 4
10 Analgesics, Non-Narcotic Phase 4
11 Analgesics, Opioid Phase 4
12 Anesthetics Phase 4
13 Anesthetics, General Phase 4
14 Anesthetics, Intravenous Phase 4
15 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2
16 Anti-Inflammatory Agents, Non-Steroidal Phase 4
17 Antirheumatic Agents Phase 4
18 Central Nervous System Depressants Phase 4
19 Cyclooxygenase 2 Inhibitors Phase 4
20 Cyclooxygenase Inhibitors Phase 4
21 Narcotics Phase 4
22 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
23 Adrenergic Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
24 Adrenergic Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
25 Adrenergic beta-Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
26 Anti-Arrhythmia Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
27 Antihypertensive Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
28 Autonomic Agents Phase 4,Phase 3,Phase 2
29 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
30 Antiemetics Phase 4,Phase 3,Phase 2
31 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2
32 Gastrointestinal Agents Phase 4,Phase 3,Phase 2
33 glucocorticoids Phase 4,Phase 3,Phase 2
34 Hormone Antagonists Phase 4,Phase 3,Phase 2
35 Hormones Phase 4,Phase 3,Phase 2
36 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2
37 Methylprednisolone acetate Phase 4,Phase 3,Phase 2
38 Methylprednisolone Hemisuccinate Phase 4,Phase 3,Phase 2
39 Neuroprotective Agents Phase 4,Phase 3,Phase 2
40 Prednisolone acetate Phase 4,Phase 3,Phase 2
41 Prednisolone hemisuccinate Phase 4,Phase 3,Phase 2
42 Prednisolone phosphate Phase 4,Phase 3,Phase 2
43 Protective Agents Phase 4,Phase 3,Phase 2
44 Vasodilator Agents Phase 4,Phase 2,Phase 3,Phase 1
45 Adrenergic Agonists Phase 4
46 Adrenergic alpha-Agonists Phase 4
47 Adrenergic alpha-2 Receptor Agonists Phase 4
48 Hypnotics and Sedatives Phase 4
49
Ephedrine Approved Phase 3 299-42-3 9294
50
Pseudoephedrine Approved Phase 3 90-82-4 7028

Interventional clinical trials:

(show top 50) (show all 181)
id Name Status NCT ID Phase
1 Role of Parecoxib Sodium for Postoperative Pain Management in Open Hepatectomy Unknown status NCT02204878 Phase 4
2 The Safety and Efficiency of Propranolol as an Initial Treatment for Pediatric Hemangioma Completed NCT01908972 Phase 4
3 Effect of Dexmedetomidine Combined With Sufentanil for Postoperative Intravenous Analgesia in Neurosurgery Recruiting NCT02552459 Phase 4
4 Apollo™ Onyx™ Delivery Micro Catheter Post Market Safety Study Active, not recruiting NCT02378883 Phase 4
5 Evaluation of Lipiodol® Ultra Fluid in Association With Surgical Glues During Vascular Embolization. Not yet recruiting NCT02625389 Phase 4
6 Postmarketing Safety Study of Hemoporfin in Patients With Port Wine Stain Not yet recruiting NCT03181984 Phase 4
7 A Pilot Study of Hemoporfin PDT in Children With Port-wine Stain Not yet recruiting NCT03125057 Phase 4
8 Visceral Artery Aneurysm Embolization by the Penumbra Ruby™ Coil System Not yet recruiting NCT02079818 Phase 4
9 Topical Timolol for Superficial Infantile Hemangioma Unknown status NCT01685398 Phase 3
10 Treatment of Port Wine Stains in Children With Pulsed Dye Laser and Timolol Gel Unknown status NCT01272609 Phase 3
11 Functional Magnetic Resonance Imagine(fMRI)Navigation in Intracranial Arteriovenous Malformation Surgery Unknown status NCT01758211 Phase 3
12 Study to Demonstrate the Efficacy and Safety of Propranolol Oral Solution in Infants With Proliferating Infantile Hemangiomas Requiring Systemic Therapy Completed NCT01056341 Phase 2, Phase 3
13 Pulse Steroids Versus Oral Steroids in Problematic Hemangiomas of Infancy Completed NCT00312520 Phase 3
14 Evaluation of Vertebroplasty Associated With Radiotherapy for Spine Metastases (EVAR) Completed NCT00267033 Phase 3
15 A Multicenter, Open-label Study for E7040 in Japanese Subjects With Hypervascular Tumor and Subjects With Arteriovenous Malformation Completed NCT01677624 Phase 3
16 A Randomized Trial of Unruptured Brain AVMs Completed NCT00389181 Phase 3
17 Nadolol Versus Propranolol in Children With Infantile Hemangiomas Recruiting NCT02505971 Phase 3
18 CyberKnife Based Hypofractionated Radiotherapy for Vertebral Hemangiomas Recruiting NCT02332408 Phase 3
19 Efficacy and Safety of Propranolol Versus Atenolol on the Proliferative Phase of Infantile Hemangioma Recruiting NCT02342275 Phase 3
20 Trial of Sirolimus for Cognitive Impairment in Sturge-Weber Syndrome Recruiting NCT03047980 Phase 2, Phase 3
21 MELABLOCK: A Clinical Trial on the Efficacy and Safety of Propranolol 80 mg in Melanoma Patients Not yet recruiting NCT02962947 Phase 2, Phase 3
22 Propranolol in Capillary Hemangiomas Terminated NCT00744185 Phase 2, Phase 3
23 Efficacy and Safety of Propranolol Versus Acebutolol on the Proliferative Phase of Infantile Hemangioma Terminated NCT01743885 Phase 3
24 Treatment of Resistant Port-wine Stains With Bosentan and Pulsed Dye Laser: a Pilot Study Unknown status NCT02317679 Phase 2
25 Nadolol for Proliferating Infantile Hemangiomas Completed NCT01010308 Phase 2
26 A Phase II Study of Imiquimod 5 % Cream for the Treatment of Hemangioma in Infancy Completed NCT00601016 Phase 2
27 Topical Timolol Gel for the Treatment of Infantile Hemangiomas Completed NCT02145884 Phase 2
28 Study in Infants With Infantile Hemangioma to Compare Propranolol Gel to Placebo Completed NCT01512173 Phase 2
29 Comparative Study of the Use of Beta Blocker and Oral Corticosteroid in the Treatment of Infantile Hemangioma Completed NCT01072045 Phase 2
30 Measurement Skin Temperature During Pulsed Laser Exposure Completed NCT00540917 Phase 2
31 The Effects of Aldara as an Adjunct to Laser Treatment Completed NCT00979550 Phase 2
32 Study Comparing Onyx and TRUFILL in Brain Arteriovenous Malformations (AVMs) Completed NCT00857662 Phase 2
33 Treatment of Von Hippel-Lindau (VHL)-Related Hemangioblastoma With PTK787/ZK 222584 Completed NCT00052013 Phase 2
34 Phase II Trial of Sunitinib (SU011248) in Patients With Recurrent or Inoperable Meningioma Completed NCT00589784 Phase 2
35 Thalidomide Reduces Arteriovenous Malformation Related Gastrointestinal Bleeding Completed NCT00389935 Phase 2
36 Efficacy and Safety Study of Topical Rapamycin Associated With Pulsed Dye Laser in Patients With Sturge-Weber Syndrome Completed NCT02080624 Phase 2
37 Vismodegib and Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Advanced or Metastatic Sarcoma Completed NCT01154452 Phase 1, Phase 2
38 Efficacy, Safety and Pharmacokinetics of Topical Timolol in Infants With Infantile Hemangioma (IH) Recruiting NCT02913612 Phase 2
39 Topical Timolol for Infantile Hemangioma in Early Proliferative Phase Recruiting NCT02731287 Phase 2
40 A Study to Compare Vincristine to Sirolimus for Treatment of High Risk Vascular Tumors Recruiting NCT02110069 Phase 2
41 A Phase I/II Trial for Intravitreous Treatment of Severe Ocular Von Hippel-Lindau Disease Using a Combination of the PDGF Antagonist E10030 and the VEGF Antagonist Ranibizumab Recruiting NCT02859441 Phase 1, Phase 2
42 Efficacy of a Timolol Nasal Spray as a Treatment for Epistaxis in Hereditary Hemorrhagic Telangiectasia (HHT) - (TEMPO) Recruiting NCT02484716 Phase 2
43 Prospective Evaluation of the Efficacy of Sirolimus (Rapamune®) in the Treatment of Severe Arteriovenous Malformations Recruiting NCT02042326 Phase 2
44 Trametinib in Treating Patients With Epithelioid Hemangioendothelioma That Is Metastatic, Locally Advanced, or Cannot Be Removed by Surgery Recruiting NCT03148275 Phase 2
45 Proton Radiotherapy for Primary Central Nervous System Tumours in Adults Recruiting NCT02797366 Phase 2
46 Gemcitabine Hydrochloride With or Without Pazopanib Hydrochloride in Treating Patients With Refractory Soft Tissue Sarcoma Recruiting NCT01532687 Phase 2
47 Trial to Evaluate the Safety of TTAC-0001(Tanibirumab) in Recurrent Glioblastoma Active, not recruiting NCT03033524 Phase 2
48 Safety and Efficacy Study of Sirolimus in Complicated Vascular Anomalies Active, not recruiting NCT00975819 Phase 2
49 Cannabidiol Expanded Access Study in Medically Refractory Sturge-Weber Syndrome Active, not recruiting NCT02332655 Phase 1, Phase 2
50 Propranolol for Prevention of Threshold Retinopathy of Prematurity Not yet recruiting NCT03083431 Phase 2

Search NIH Clinical Center for Hemangioma

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: hemangioma

Genetic Tests for Hemangioma

Genetic tests related to Hemangioma:

id Genetic test Affiliating Genes
1 Hemangioma 29

Anatomical Context for Hemangioma

MalaCards organs/tissues related to Hemangioma:

39
Endothelial, Liver, Lung, Bone, Skin, Breast, Thyroid
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Hemangioma:
id Tissue Anatomical CompartmentCell Relevance
1 Heart Cardinal Veins Venous Endothelial Cells Affected by disease

Publications for Hemangioma

Articles related to Hemangioma:

(show top 50) (show all 2382)
id Title Authors Year
1
Growing skull hemangioma: first and unique description in a patient with Klippel-TrAcnaunay-Weber syndrome. ( 27822901 )
2017
2
Propranolol as First Line Treatment for Life-threatening Diffuse Infantile Hepatic Hemangioma: A Case Report. ( 28056491 )
2017
3
Segmental hemangioma of the head and neck: High prevalence of PHACE syndrome. ( 28089002 )
2017
4
Rapamycin inhibits the proliferation of endothelial cells in hemangioma by blocking the mTOR-FABP4 pathway. ( 27914823 )
2017
5
A case of diffuse cavernous hemangioma of the appendix: laparoscopic surgery can facilitate diagnosis and treatment. ( 28054281 )
2017
6
Anastomosing Hemangioma of the Ovary: A Clinicopathological Study of Six Cases with Stromal Luteinization. ( 28050796 )
2017
7
Mixed Hemangioma of the Nasal Cavity Destructing the Nasal Bone. ( 28060104 )
2017
8
The pigment epithelium-derived factor (PEDF): an important potential therapeutic agent for infantile hemangioma. ( 28197761 )
2017
9
Utility of the Hemangioma Severity Scale as a Triage Tool and Predictor of Need for Treatment. ( 27981617 )
2017
10
A Case of Giant Intradural Extramedullary Capillary Hemangioma. ( 28091424 )
2017
11
Acquired hemangioma with features of Dabska tum or: an additional case. ( 27804154 )
2017
12
Tricuspid Valve Hemangioma Associated with Hypoplastic Left Heart Syndrome Presenting as Sudden Infant Death Syndrome. ( 28272668 )
2017
13
Ultrasound Diagnosis of Scrotal Wall Cavernous Hemangioma. ( 27981934 )
2016
14
History of the infantile hepatic hemangioma: From imaging to generating a differential diagnosis. ( 27610342 )
2016
15
Sclerosing hemangioma: A diagnostic dilemma in fine needle aspiration cytology. ( 27168758 )
2016
16
Inheritance Patterns of Infantile Hemangioma. ( 27940781 )
2016
17
Transcervical excision of intramasseteric cavernous hemangioma: A case report. ( 26998058 )
2016
18
Intracranial Capillary Hemangioma in the Posterior Fossa of an Adult Male. ( 27747124 )
2016
19
Preoperative Diagnosis in 46 Cases of Pulmonary Sclerosing Hemangioma. ( 27231179 )
2016
20
Juvenile capillary hemangioma. ( 27057499 )
2016
21
Postictal Prosopometamorphopsia after Focal Status Epilepticus due to Cavernous Hemangioma in the Right Occipital Lobe. ( 27095527 )
2016
22
Capillary hemangioma or pyogenic granuloma. ( 27041829 )
2016
23
Cavernous Hemangioma of the Rib: A Case Report. ( 27878064 )
2016
24
Cavernous hemangioma in unusual location: pterygopalatine fossa. ( 27117893 )
2016
25
A case of giant fetal intracranial capillary hemangioma cured with propranolol. ( 26824594 )
2016
26
Ectopic ACTH syndrome caused by pulmonary carcinoid tumor mimicking long-standing sclerosing hemangioma. ( 26828249 )
2016
27
Intradural extramedullary capillary hemangioma: A case report and review of the literature. ( 27073572 )
2016
28
Pleural effusion caused by a capillary hemangioma in the pleural cavity. ( 27087237 )
2016
29
How to manage testicular capillary haemangioma: Editorial Comment on: W. BiaA8ek, S. Rudzki, L. Wroniecki: Capillary hemangioma of the testis. A case report of a rare benign tumor. ( 27104008 )
2016
30
Visual function alterations in cavernous hemangioma of the orbital apex after surgery. ( 27803876 )
2016
31
Anatomical patterns of infantile hemangioma (IH) of the extremities (IHE). ( 27114263 )
2016
32
EP10.01: Isolated fetal neck hemangioma mimicking thyroid. ( 27644985 )
2016
33
Intramuscular Hemangioma of the Pronator Quadratus Muscle of Forearm. ( 27454644 )
2016
34
Spectral-Domain Optical Coherence Tomography Findings in Cavernous Hemangioma of the Optic Disk. ( 27552290 )
2016
35
Multiparametric sonographic imaging of a capillary hemangioma of the testis: appearances on gray-scale, color Doppler, contrast-enhanced ultrasound and strain elastography. ( 26941881 )
2016
36
Intramuscular hemangioma of the arm: ultrasonography and pathology features. ( 27516028 )
2016
37
Resection of Giant Hemangioma of the Tongue Utilizing a Miniature Tourniquet Technique. ( 27391511 )
2016
38
Neonatal Abdominal Hemangiomatosis: Propranolol beyond Infantile Hemangioma. ( 27110421 )
2016
39
Epidural spinal cavernous hemangioma and hybrid vascular subtype. ( 27487399 )
2016
40
Calvarial bone cavernous hemangioma with intradural invasion: An unusual aggressive course-Case report and literature review. ( 27061482 )
2016
41
Glomeruloid hemangioma and POEMS syndrome. ( 27208909 )
2016
42
Intracranial capillary hemangioma misdiagnosed as a meningioma. ( 27097011 )
2016
43
A very rare cause of abdominal pain in a male adolescent: cavernous hemangioma. ( 27599403 )
2016
44
Degenerative hepatic hemangioma mimicking biliary cystadenocarcinoma. ( 26896817 )
2016
45
Prenatal diagnosis of thrombosed dural sinus malformation with periorbital hemangioma: a case report. ( 26603566 )
2016
46
Dyschromatosis symmetrica hereditaria complicated by intracranial hemangiomas and Parry-Romberg syndrome. ( 27040761 )
2016
47
Endothelial and circulating C19MC microRNAs are biomarkers of infantile hemangioma. ( 27660822 )
2016
48
Whole-exome sequencing identifies recurrent AKT1 mutations in sclerosing hemangioma of lung. ( 27601661 )
2016
49
Pure laparoscopic right hepatectomy for giant hemangioma using anterior approach. ( 27620909 )
2016
50
Choroidal haemangioma and photodynamic therapy. Anatomical and functional response of patients with choroidal hemangioma treated with photodynamic therapy. ( 28017484 )
2016

Variations for Hemangioma

Expression for Hemangioma

Search GEO for disease gene expression data for Hemangioma.

Pathways for Hemangioma

Pathways related to Hemangioma according to GeneCards Suite gene sharing:

(show all 19)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.17 ANGPT1 ANGPT2 FGF2 FLT4 KDR SLC2A1
2
Show member pathways
12.4 ANGPT1 ANGPT2 FGF2 FLT4 KDR KRIT1
3 12.33 ANGPT1 ANGPT2 FGF2 FLT4 KDR TEK
4
Show member pathways
12.25 FGF2 FLT4 KDR VEGFA
5
Show member pathways
12.1 ANGPT1 ANGPT2 PECAM1 TEK
6 11.95 ANGPT2 FGF2 FLT4 KDR TEK
7 11.92 FGF2 KDR PROX1 VEGFA
8
Show member pathways
11.72 FLT4 KDR VEGFA
9 11.72 ANGPT1 ANGPT2 SLC2A1 TEK VEGFA
10 11.71 ANGPT1 TEK VEGFA
11 11.66 FGF2 SLC2A1 SYP VEGFA
12 11.44 ACTC1 FGF2 KDR
13 11.39 FGF2 KDR VEGFA
14 11.35 FGF2 KDR VEGFA
15 11.24 ANGPT1 ANGPT2 SLC2A1 VEGFA
16 11.18 KDR SLC2A1 VEGFA
17 11.11 ANGPT2 FGF2 FLT4 KDR PECAM1 PROX1
18
Show member pathways
10.81 FLT4 KDR VEGFA
19 10.73 ANGPT1 FGF2 KDR TEK VEGFA

GO Terms for Hemangioma

Cellular components related to Hemangioma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.85 ANGPT1 ANGPT2 CD34 CHGA FGF2 FLT4
2 extracellular space GO:0005615 9.61 ACTC1 ANGPT1 ANGPT2 CHGA FGF2 KRIT1
3 cell periphery GO:0071944 9.43 CD34 LYVE1 PECAM1
4 membrane raft GO:0045121 9.02 ANGPT1 KDR PECAM1 SLC2A1 TEK

Biological processes related to Hemangioma according to GeneCards Suite gene sharing:

(show all 38)
id Name GO ID Score Top Affiliating Genes
1 peptidyl-tyrosine phosphorylation GO:0018108 9.92 FGF2 FLT4 KDR TEK
2 positive regulation of protein phosphorylation GO:0001934 9.91 FLT4 KDR TEK VEGFA
3 leukocyte migration GO:0050900 9.89 ANGPT1 ANGPT2 CD34 PECAM1 TEK
4 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.88 ANGPT1 FGF2 FLT4 KDR TEK
5 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.87 ANGPT1 FLT4 KDR TEK
6 lung development GO:0030324 9.85 NKX2-1 PDPN PROX1 VEGFA
7 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.83 FLT4 KDR VEGFA
8 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.82 ANGPT1 KDR TEK
9 negative regulation of angiogenesis GO:0016525 9.81 ANGPT2 KRIT1 TEK
10 positive chemotaxis GO:0050918 9.77 ANGPT1 FGF2 VEGFA
11 sprouting angiogenesis GO:0002040 9.73 ANGPT1 FLT4 TEK
12 positive regulation of angiogenesis GO:0045766 9.73 ANGPT2 CD34 FGF2 KDR TEK VEGFA
13 positive regulation of focal adhesion assembly GO:0051894 9.71 KDR TEK VEGFA
14 negative regulation of endothelial cell apoptotic process GO:2000352 9.71 ANGPT1 KDR KRIT1 TEK
15 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.7 FLT4 KDR VEGFA
16 positive regulation of blood vessel endothelial cell migration GO:0043536 9.69 ANGPT1 FGF2 VEGFA
17 negative regulation of blood vessel endothelial cell migration GO:0043537 9.68 ANGPT2 FGF2
18 lymph vessel development GO:0001945 9.67 FLT4 PROX1
19 positive regulation of positive chemotaxis GO:0050927 9.67 KDR VEGFA
20 positive regulation of cellular component movement GO:0051272 9.66 PDPN VEGFA
21 positive regulation of vasculogenesis GO:2001214 9.66 CD34 KDR
22 stem cell proliferation GO:0072089 9.65 CD34 FGF2
23 positive regulation of protein kinase C signaling GO:0090037 9.63 FLT4 VEGFA
24 vascular endothelial growth factor signaling pathway GO:0038084 9.63 FLT4 KDR
25 cell migration involved in sprouting angiogenesis GO:0002042 9.63 FGF2 KDR VEGFA
26 positive regulation of endothelial cell proliferation GO:0001938 9.63 FGF2 FLT4 KDR PROX1 TEK VEGFA
27 endothelium development GO:0003158 9.62 CD34 KDR
28 skeletal muscle thin filament assembly GO:0030240 9.61 ACTC1 PROX1
29 lymphangiogenesis GO:0001946 9.61 FLT4 PDPN PROX1
30 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.6 KDR VEGFA
31 glomerular endothelium development GO:0072011 9.58 CD34 PECAM1
32 angiogenesis GO:0001525 9.56 ANGPT1 ANGPT2 FGF2 FLT4 KDR KRIT1
33 glomerulus vasculature development GO:0072012 9.54 ANGPT1 ANGPT2 TEK
34 Tie signaling pathway GO:0048014 9.5 ANGPT1 ANGPT2 TEK
35 positive regulation of endothelial cell migration GO:0010595 9.1 ANGPT1 FLT4 KDR PROX1 TEK VEGFA
36 multicellular organism development GO:0007275 10.19 ANGPT1 ANGPT2 FGF2 KDR PDPN PROX1
37 positive regulation of cell proliferation GO:0008284 10.07 FGF2 FLT4 KDR PROX1 VEGFA
38 negative regulation of apoptotic process GO:0043066 10.06 ACTC1 ANGPT1 FLT4 KDR TEK VEGFA

Molecular functions related to Hemangioma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.33 FLT4 KDR TEK
2 vascular endothelial growth factor-activated receptor activity GO:0005021 9.26 FLT4 KDR
3 protein tyrosine kinase activity GO:0004713 9.26 FGF2 FLT4 KDR TEK
4 growth factor binding GO:0019838 8.8 FLT4 KDR TEK

Sources for Hemangioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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