MCID: HMN012
MIFTS: 50

Hemangioma of Lung malady

Respiratory diseases category

Summaries for Hemangioma of Lung

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32MalaCards
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MalaCards: Hemangioma of Lung, also known as pulmonary hemangioma, is related to sclerosing hemangioma and hemangioma. An important gene associated with Hemangioma of Lung is STK11 (serine/threonine kinase 11), and among its related pathways are Inhibition of TSC complex formation by PKB and LKB1 signaling events. The compounds cycloheximide and exemestane have been mentioned in the context of this disorder. Affiliated tissues include lung, endothelial and tongue, and related mouse phenotypes are vision/eye and endocrine/exocrine gland.

Aliases & Classifications for Hemangioma of Lung

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8Disease Ontology, 10DISEASES, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases


Aliases & Descriptions:

hemangioma of lung 8 10
pulmonary hemangioma 8


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Disease Ontology8 DOID:490

Related Diseases for Hemangioma of Lung

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17GeneCards, 18GeneDecks
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Diseases related to Hemangioma of Lung via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 201)
idRelated DiseaseScoreTop Affiliating Genes
1sclerosing hemangioma30.4SFTPB
2hemangioma30.4NKX2-1, SFTPB
3lung adenocarcinoma30.0CEACAM3, TSC2, ERBB2, KRAS, CDKN2A, MUC1
4adenocarcinoma29.9CEACAM3, TSC2, TSC1, ERBB2, PTEN, KRAS
5pulmonary sclerosing hemangioma10.0
6merkel cell carcinoma10.0NKX2-1
7esophagitis10.0GAST
8wilms tumor10.0NKX2-1
9pneumothorax10.0TSC1
10angiosarcoma10.0MUC1
11gastritis10.0GAST
12pulmonary blastoma10.0NKX2-1
13perivascular epithelioid cell tumor10.0TSC2
14pancreatitis10.0KRAS
15duodenitis10.0GAST
16thyroiditis10.0CALCA
17kidney rhabdoid cancer10.0TSC2
18neurofibroma10.0MUC1
19von hippel-lindau disease10.0TSC2
20rhabdoid tumor10.0MUC1
21hypertension10.0CALCA
22hidradenoma10.0MUC1
23hypothyroidism10.0NKX2-1
24colon adenocarcinoma10.0KRAS
25benign mesothelioma10.0NKX2-1
26teratoma10.0NKX2-1
27apudoma10.0CALCA
28hepatitis c10.0KRAS
29myeloid leukemia10.0CDKN3
30hepatitis b10.0KRAS
31interstitial lung disease10.0MUC1
32myoma10.0PGR
33diabetes mellitus10.0CALCA
34bilateral breast cancer10.0PGR
35hemangiopericytoma10.0MUC1
36pituitary adenoma10.0RB1
37alopecia10.0AR
38thymoma10.0CEACAM3, NKX2-1
39pituitary tumors10.0RB1
40gastrinoma10.0GAST
41rhabdomyosarcoma10.0RB1
42chordoma10.0CEACAM3, MUC1
43liposarcoma10.0RB1
44liver cirrhosis10.0KRAS
45gliosarcoma10.0PTEN
46cystadenocarcinoma10.0CEACAM3, MUC1
47eccrine porocarcinoma10.0MUC1
48uterine carcinosarcoma10.0ERBB2
49prostatic hypertrophy10.0AR
50gliomatosis cerebri10.0PTEN

Graphical network of the top 20 diseases related to Hemangioma of Lung:



Diseases related to hemangioma of lung

Clinical Features for Hemangioma of Lung

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Drugs & Therapeutics for Hemangioma of Lung

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Hemangioma of Lung

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Genetic Tests for Hemangioma of Lung

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Anatomical Context for Hemangioma of Lung

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32MalaCards
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MalaCards organs/tissues related to Hemangioma of Lung:

32
Lung, Endothelial, Tongue, Thyroid, Fetal lung

Animal Models for Hemangioma of Lung or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Hemangioma of Lung:

36 (show all 23)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053919.8MUC1, EGFR, STK11
2MP:00053799.6KRAS, CDKN2A, GAST, RB1
3MP:00053809.6ERBB2, TSC2, TSC1, PGR, AR
4MP:00036319.5PRKG1, NKX2-1, ERBB2, TSC1
5MP:00053909.5AR, TSC1, PGR, NKX2-1, RB1
6MP:00053699.4PRKG1, RB1, TSC1, CDKN2A
7MP:00053769.3PGR, CALCA, TSC2, GAST, AR, TSC1
8MP:00053679.0AR, STK11, PRKG1, TSC1, TSC2, EGFR
9MP:00053888.9ERBB2, EGFR, TSC1, PTEN, SFTPB, KRAS
10MP:00107718.7KRAS, STK11, RB1, CALCA, PTEN, TSC1
11MP:00030128.5NKX2-1, EGFR, CDKN2A, RB1, STK11, PGR
12MP:00053708.3PTEN, STK11, RB1, EGFR, MUC1, CDKN2A
13MP:00053898.3STK11, EGFR, PRKG1, CDKN2A, KRAS, PTEN
14MP:00053787.8AR, STK11, RB1, NKX2-1, TSC2, TSC1
15MP:00053977.7TSC2, PTEN, AR, STK11, RB1, PRKG1
16MP:00028737.5MUC1, PRKG1, PTEN, EGFR, TSC2, RB1
17MP:00053817.4PTEN, CDKN2A, GAST, ERBB2, KRAS, MUC1
18MP:00053877.4KRAS, PGR, PRKG1, EGFR, RB1, AR
19MP:00053857.3AR, TSC1, ERBB2, KRAS, TSC2, PGR
20MP:00053867.2PGR, KRAS, PTEN, ERBB2, TSC1, TSC2
21MP:00053847.2AR, TSC2, TSC1, ERBB2, PTEN, STK11
22MP:00020067.1NKX2-1, STK11, RB1, EGFR, MUC1, CDKN2A
23MP:00107686.5EGFR, CALCA, ERBB2, SFTPB, TSC1, GAST

Publications for Hemangioma of Lung

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50PubMed
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Articles related to Hemangioma of Lung:

(show top 50)    (show all 80)
idTitleAuthorsYear
1
Pneumocytoma (formerly known as sclerosing hemangioma of the lung): a rare cause of chest pain. (23380035)
2013
2
An unusual case of cavernous hemangioma of the rib in a young man with lung tuberculosis: a brief review and case report. (23728568)
2013
3
A rare tumor of the lung: pulmonary sclerosing hemangioma (pneumocytoma). (23290153)
2013
4
Pulmonary sclerosing hemangioma: a unique epithelial neoplasm of the lung (report of 26 cases). (23587094)
2013
5
Sclerosing hemangioma of the lung manifesting as a cystic lesion with an air-fluid level. (22832056)
2012
6
Treatment of 28 patients with sclerosing hemangioma (SH) of the lung. (22515818)
2012
7
Metastatic adenocarcinoma from the lung diagnosed by presenting sign of a hemangioma-like cutaneous lesion. (23165850)
2012
8
Napsin A is differentially expressed in sclerosing hemangiomas of the lung. (23194051)
2012
9
Changes in CT density of solitary capillary hemangioma of the lung upon varying patient position. (22875585)
2012
10
Sclerosing hemangioma of the lung. (19415961)
2009
11
Role of the PI3K/Akt, mTOR, and STK11/LKB1 pathways in the tumorigenesis of sclerosing hemangioma of the lung. (18067639)
2008
12
Proximal nerve root capillary hemangioma presenting as a lung mass with bandlike chest pain: case report and review of literature. (16720181)
2006
13
Sclerosing hemangioma of the lung: a benign tumour with potential for malignancy? (17095978)
2006
14
Radiology-pathology conference: sclerosing hemangioma of the lung. (17101410)
2006
15
Expression of the estrogen receptor beta in 37 surgically treated pulmonary sclerosing hemangiomas in comparison with non-small cell lung carcinomas. (16226111)
2005
16
Endobronchial variant of sclerosing hemangioma of the lung: histological and cytological features on endobronchial material. (14704717)
2004
17
A case of sclerosing hemangioma of the lung presenting as a gigantic tumor occupying the left thoracic cavity. (12715177)
2003
18
Sclerosing hemangioma of the lung. (12938610)
2003
19
Sclerosing hemangioma of the lung: an analysis of 44 cases. (12728972)
2003
20
Air-trapping zone surrounding sclerosing hemangioma of the lung. (12016362)
2002
21
Expression of thyroid transcription factor-1 and other markers in sclerosing hemangioma of the lung. (11570910)
2001
22
FDG-PET findings in sclerosing hemangioma of the lung: a case report. (11550723)
2001
23
Sclerosing hemangioma of the lung. (11089322)
2000
24
Sclerosing hemangioma of the lung: MR findings and correlation with pathological features. (9843249)
1998
25
Sclerosing hemangioma of the lung: a case report. (8956547)
1996
26
A case of sclerosing hemangioma of the lung: correlation of MR images with pathological findings. (7667514)
1995
27
Sclerosing hemangioma of the lung: radiological findings and pathological diagnosis. (8577531)
1995
28
Sclerosing hemangioma of the lung. Granulomatous variant. (7944888)
1994
29
Sclerosing hemangioma of the lung: pathological study and enzyme immunoassay for estrogen and progesterone receptors. (8237370)
1993
30
Fine needle aspiration biopsy cytology of sclerosing hemangioma of the lung. A case report. (8249516)
1993
31
Fine-needle aspiration cytology of sclerosing hemangioma of the lung: case report with immunohistochemical study. (8519196)
1993
32
Sclerosing hemangioma of the lung: a clinicopathologic study. (8252456)
1993
33
Estrogen and progesterone receptors in lymphangioleiomyomatosis, epithelioid hemangioendothelioma, and sclerosing hemangioma of the lung. (1716416)
1991
34
So-called sclerosing hemangioma of the lung. An immunohistochemical, histochemical and ultrastructural study. (2463730)
1988
35
So-called sclerosing hemangioma of the lung with nuclear inclusion bodies. Immunohistochemical study of a case. (2847478)
1988
36
Sclerosing hemangioma of the lung. An epithelial tumor composed of immunohistochemically heterogenous cells. (2823596)
1987
37
Sclerosing hemangioma of the lung: report of a case. (2824660)
1987
38
Fine needle aspiration cytology of sclerosing hemangioma of the lung, a mimicker of bronchioloalveolar carcinoma. (3004083)
1986
39
Is sclerosing hemangioma of lung an alveolar mixed tumour? (6310472)
1983
40
Sclerosing hemangioma of the lung: an ultrastructural study. (225006)
1979
41
The air meniscus sign in sclerosing hemangioma of the lung. (208101)
1978
42
Capillary hemangioma of the lung. Radiological quiz. (866635)
1977
43
Sclerosing hemangioma of the lung: an endothelial or epithelial neoplasm? (196998)
1977
44
Ultrastructure of a sclerosing hemangioma of the lung. (4340663)
1972
45
Sclerosing hemangioma of the lung. (5676973)
1968
46
Sclerosing hemangioma of the lung. (13667023)
1959
47
Concerning a case of capillary hemangioma of the lung. (13397449)
1957
48
Sclerosing hemangioma of the lung; an interesting problem of differential diagnosis. (13444086)
1957
49
Sclerosing hemangioma (histiocytoma, xanthoma) of the lung. (13284701)
1956
50
Capillary hemangioma of the lung. (14391169)
1955

Genetic Variations for Hemangioma of Lung

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Expression for genes affiliated with Hemangioma of Lung

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hemangioma of Lung

Search GEO for disease gene expression data for Hemangioma of Lung.

Pathways for genes affiliated with Hemangioma of Lung

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Sources:
53Reactome, 37NCBI BioSystems Database, 12EMD Millipore, 4Cell Signaling Technology, 55SinoBiological, 52R&D Systems, 29KEGG, 51QIAGEN
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Pathways related to Hemangioma of Lung according to GeneCards/GeneDecks:

(show all 39)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1TSC1, TSC2
29.9TSC2, STK11, TSC1
3
Hide members
9.9TSC2, TSC1, STK11
49.9STK11, TSC1, TSC2
5
Hide members
9.8TSC1, PTEN, TSC2
69.8PTEN, TSC1, TSC2
7
Hide members
9.7TSC2, KRAS, STK11, TSC1
89.6EGFR, ERBB2, MUC1
9
Hide members
9.6ERBB2, KRAS, EGFR
109.6EGFR, ERBB2, AR
11
Hide members
9.5KRAS, MUC1, PTEN, RB1
12
Hide members
9.5KRAS, TSC2, PTEN, ERBB2
13
Development Endothelin-1/EDNRA signaling
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9.4EGFR, KRAS, PTEN, TSC2
14
Hide members
9.4PTEN, RB1, CDKN2A, TSC2
159.4RB1, TSC2, PTEN, EGFR
16
Hide members
9.4KRAS, TSC2, TSC1, AR, RB1
179.3RB1, PTEN, EGFR, AR
18
Hide members
9.3RB1, TSC2, TSC1, PTEN, AR
19
Hide members
9.3PTEN, KRAS, EGFR, ERBB2
20
Hide members
9.3RB1, EGFR, PTEN, ERBB2
21
Hide members
9.2TSC2, TSC1, PRKG1, EGFR
22
Hide members
9.1TSC2, PTEN, ERBB2, EGFR, KRAS
23
Hide members
9.1EGFR, KRAS, PTEN, TSC2, ERBB2
24
Hide members
9.1TSC2, PTEN, KRAS, EGFR, ERBB2
25
Hide members
9.1KRAS, ERBB2, EGFR, PTEN, TSC2
26
Transcription Androgen Receptor nuclear signaling
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9.1AR, TSC2, ERBB2, PTEN, EGFR
279.1KRAS, TSC1, PTEN, TSC2, STK11, EGFR
28
Hide members
9.1RB1, TSC2, STK11, TSC1, PTEN, ERBB2
29
Hide members
9.0KRAS, EGFR, ERBB2, CDKN2A, RB1
309.0KRAS, EGFR, ERBB2, PTEN, CDKN2A
318.9TSC1, TSC2, KRAS, PTEN, EGFR, ERBB2
32
Hide members
8.9TSC2, ERBB2, PTEN, AR, TSC1, EGFR
338.9RB1, TSC1, CDKN2A, PTEN, TSC2, EGFR
348.9KRAS, EGFR, PTEN, ERBB2, AR, STK11
35
Hide members
8.9ERBB2, PTEN, KRAS, TSC2, PGR, EGFR
36
Translation Insulin regulation of translation
Hide members
8.8ERBB2, KRAS, PTEN, EGFR, STK11, TSC2
378.6PTEN, TSC1, STK11, KRAS, TSC2, RB1
388.5ERBB2, PTEN, KRAS, CDKN2A, EGFR, AR
39
Hide members
7.9TSC2, TSC1, ERBB2, PGR, EGFR, CALCA

Compounds for genes affiliated with Hemangioma of Lung

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Sources:
44Novoseek, 49PharmGKB, 59Tocris Bioscience, 11DrugBank, 28IUPHAR, 2BitterDB, 24HMDB
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Compounds related to Hemangioma of Lung according to GeneCards/GeneDecks:

(show top 50)    (show all 160)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.7SFTPB
2exemestane49 44 59 1112.6PGR, AR, EGFR, ERBB2
3dexamethasone44 49 28 1112.6SFTPB, AR, CDKN2A, RB1, NKX2-1
4lapatinib44 49 1111.6EGFR, PGR, ERBB2, AR
5crcs449.6KRAS, CDKN2A, MUC1, RB1, PTEN
6fulvestrant44 49 28 1112.6AR, EGFR, ERBB2, PGR
7hematoxylin449.5NKX2-1, PTEN, CEACAM3, MUC1, CDKN2A
8letrozole44 49 59 1112.5AR, ERBB2, PGR, EGFR
9taxane449.5PTEN, PGR, EGFR, ERBB2
10leucovorin44 49 1111.3EGFR, PGR, KRAS, ERBB2, CEACAM3
11panitumumab44 49 1111.3PTEN, KRAS, EGFR
12chloramphenicol44 2 1111.3PRKG1, SFTPB, MUC1, CDKN2A, ERBB2
13cetuximab44 49 1111.2ERBB2, PTEN, CDKN3, EGFR, KRAS
14progestin449.2ERBB2, EGFR, AR, PGR, MUC1
15erlotinib44 49 1111.2ERBB2, KRAS, PTEN, CDKN3, EGFR
16irinotecan44 49 1111.2CEACAM3, ERBB2, EGFR, CDKN2A, KRAS
17gefitinib44 49 1111.1EGFR, KRAS, ERBB2, PTEN, CDKN3
18trastuzumab44 49 1111.1PTEN, ERBB2, PGR, CDKN3, MUC1, EGFR
19tetracycline44 1110.0EGFR, RB1, GAST, ERBB2, CDKN2A
20guanine44 11 2411.0STK11, ERBB2, PGK1, PRKG1, AR, CALCA
21adriamycin449.0RB1, MUC1, CDKN2A, ERBB2, PGK1, PGR
22cyclic amp44 2410.0SFTPB, STK11, CALCA, NKX2-1, MUC1, CDKN2A
23steroid449.0RB1, TSC2, AR, ERBB2, CDKN2A, NKX2-1
24biotin44 11 2410.9RB1, CDKN2A, ERBB2, MUC1, CDKN3
25methotrexate44 49 1110.8CDKN2A, ERBB2, MUC1, CEACAM3, RB1, PGR
26tamoxifen44 49 28 1111.8MUC1, AR, CEACAM3, EGFR, PGR, PTEN
27glycogen44 249.8TSC2, PRKG1, MUC1, CDKN3, STK11, PTEN
28agar448.7RB1, EGFR, MUC1, CDKN2A, PTEN, PGR
29paclitaxel44 49 1110.7CDKN2A, EGFR, PGR, PGK1, KRAS, PTEN
30ly294002448.5AR, RB1, EGFR, CDKN3, KRAS, PTEN
31polyacrylamide448.5SFTPB, KRAS, PGK1, PRKG1, GAST, RB1
32serine448.5TSC2, TSC1, ERBB2, KRAS, CDKN3, NKX2-1
33doxorubicin44 49 1110.5PTEN, PGR, CDKN2A, EGFR, AR, RB1
34h2o2448.5CDKN2A, CDKN3, AR, RB1, PGK1, PTEN
35genistein44 28 59 2 11 2413.4RB1, PGR, EGFR, CDKN2A, CDKN3, ERBB2
365fluorouracil448.4RB1, EGFR, MUC1, PGR, PTEN, ERBB2
37rapamycin448.2AR, STK11, RB1, EGFR, CDKN3, KRAS
38cisplatin44 49 59 1111.1ERBB2, PTEN, KRAS, CDKN3, GAST, CDKN2A
39glucose448.1CEACAM3, TSC2, PTEN, TSC1, GAST, STK11
40aspartate448.1PRKG1, CDKN3, CDKN2A, PTEN, AR, CEACAM3
41alanine448.0PTEN, GAST, CDKN2A, TSC1, ERBB2, PGR
42oxygen44 249.0CDKN2A, RB1, PRKG1, SFTPB, MUC1, STK11
43threonine448.0SFTPB, STK11, NKX2-1, MUC1, CDKN2A, CDKN3
44retinoic acid44 249.0MUC1, CDKN2A, PGR, KRAS, PTEN, NKX2-1
45progesterone44 59 28 11 2412.0PGR, SFTPB, AR, RB1, PTEN, NKX2-1
46atp44 288.9PGK1, CDKN2A, PTEN, PRKG1, RB1, TSC2
47paraffin447.2PGR, CDKN2A, MUC1, EGFR, RB1, STK11
48testosterone44 59 11 249.7RB1, EGFR, PRKG1, MUC1, TSC2, ERBB2
49tyrosine446.6CEACAM3, MUC1, CDKN3, PGK1, KRAS, PTEN
50vegf445.6CALCA, SFTPB, GAST, AR, STK11, RB1

GO Terms for genes affiliated with Hemangioma of Lung

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16Gene Ontology
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Cellular components related to Hemangioma of Lung according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1TSC1-TSC2 complexGO:0335969.8TSC2, TSC1
2protein complexGO:0432349.6TSC1, CDKN2A, STK11, AR

Biological processes related to Hemangioma of Lung according to GeneCards/GeneDecks:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1tertiary branching involved in mammary gland duct morphogenesisGO:06074810.3AR, PGR
2protein heterooligomerizationGO:05129110.2TSC2, TSC1, STK11
3negative regulation of cell sizeGO:04579210.2PTEN, TSC1, TSC2
4morphogenesis of an epithelial foldGO:06057110.2AR, EGFR
5prostate gland growthGO:06073610.2AR, PTEN
6negative regulation of immature T cell proliferation in thymusGO:03308810.1CDKN2A, ERBB2
7cerebral cortex cell migrationGO:02179510.1NKX2-1, EGFR
8positive regulation of transcription from RNA polymerase III promoterGO:04594510.1AR, ERBB2
9insulin receptor signaling pathwayGO:00828610.0TSC2, TSC1, KRAS, STK11
10positive regulation of macrophage differentiationGO:04565110.0CALCA, RB1
11negative regulation of protein kinase activityGO:0064699.9TSC2, CDKN2A, RB1
12negative regulation of epithelial cell proliferationGO:0506809.9TSC2, PTEN, RB1, AR
13positive regulation of MAP kinase activityGO:0434069.8EGFR, KRAS, ERBB2
14protein stabilizationGO:0508219.8CDKN2A, PTEN, TSC1
15Ras protein signal transductionGO:0072659.8KRAS, CDKN2A, RB1
16negative regulation of phosphatidylinositol 3-kinase cascadeGO:0140679.7TSC2, PTEN
17phosphatidylinositol-mediated signalingGO:0480159.6TSC2, ERBB2, PTEN, EGFR
18positive regulation of protein phosphorylationGO:0019349.6ERBB2, KRAS, EGFR
19fibroblast growth factor receptor signaling pathwayGO:0085439.5TSC2, ERBB2, PTEN, KRAS, EGFR
20Fc-epsilon receptor signaling pathwayGO:0380959.4EGFR, KRAS, PTEN, ERBB2, TSC2
21epidermal growth factor receptor signaling pathwayGO:0071739.4EGFR, KRAS, PTEN, ERBB2, TSC2
22neurotrophin TRK receptor signaling pathwayGO:0480119.4EGFR, KRAS, PTEN, ERBB2, TSC2
23cell cycle arrestGO:0070509.3TSC2, STK11, RB1, CDKN2A, CDKN3, TSC1
24negative regulation of cell proliferationGO:0082859.2STK11, CDKN2A, CDKN3, PTEN, TSC1, TSC2
25signal transductionGO:0071658.3GAST, AR, EGFR, PRKG1, PGR, ERBB2

Molecular functions related to Hemangioma of Lung according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1LRR domain bindingGO:03027510.1KRAS, STK11
2epidermal growth factor-activated receptor activityGO:0050069.9EGFR, ERBB2
3p53 bindingGO:0020399.9CDKN2A, MUC1, STK11
4receptor signaling protein tyrosine kinase activityGO:0047169.8ERBB2, EGFR
5enzyme bindingGO:0198999.1PTEN, PGR, EGFR, AR
6identical protein bindingGO:0428029.0CALCA, STK11, RB1, EGFR, ERBB2
7protein bindingGO:0055155.7TSC2, CALCA, GAST, AR, STK11, RB1

Products for genes affiliated with Hemangioma of Lung

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet