MCID: HMN013
MIFTS: 51

Hemangiopericytoma malady

Rare diseases, Cancer diseases categories

Summaries for Hemangiopericytoma

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NIH Rare Diseases:41 Hemangiopericytoma is a term used to described a group of tumors that are derived from pericytes, the cells normally arranged along specific types of blood vessels called capillaries and venules. these types of tumors are typically slow-growing, may be either benign (non-cancerous) or malignant (cancerous), and may occur anywhere in the body. last updated: 11/19/2013

MalaCards based summary: Hemangiopericytoma, also known as solitary fibrous tumor, is related to infantile myofibromatosis and fasciitis, and has symptoms including autosomal recessive inheritanceand abnormality of the cardiovascular system. An important gene associated with Hemangiopericytoma is NAB2 (NGFI-A binding protein 2 (EGR1 binding protein 2)), and among its related pathways are Aurora B signaling and Cardiac Progenitor Differentiation. The compounds eosin and toluidine have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and breast, and related mouse phenotypes are liver/biliary system and tumorigenesis.

Disease Ontology:9 A soft tissue cancer that is a soft tissue sarcoma and originates in the pericytes in the walls of capillaries.

Wikipedia:63 A hemangiopericytoma (HPC) is a type of soft tissue sarcoma that originates in the pericytes in the... more...

Aliases & Classifications for Hemangiopericytoma

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Sources:
9Disease Ontology, 41NIH Rare Diseases, 11DISEASES, 43Novoseek, 60UMLS, 47Orphanet, 55SNOMED-CT, 38NCIt, 33MeSH, 34MESH via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet
See all sources

Hemangiopericytoma, Aliases & Descriptions:

Name: Hemangiopericytoma 9 41 11 43 60
Solitary Fibrous Tumor 41 47 60
Hemangiopericytoma, Malignant 9 60
 
Haemangiopericytic Meningioma 9
Malignant Hemangiopericytoma 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Orphanet: 47 
Rare tumors


Characteristics (Orphanet epidemiological data):

47
solitary fibrous tumor:
Age of onset: All ages; Age of death: any age


External Ids:

Disease Ontology9 DOID:264
NCIt38 C3087
MeSH33 D006393
Orphanet47 2126
SNOMED-CT55 36060005, 134335004
MESH via Orphanet34 D006393
ICD10 via Orphanet26 C49.9
UMLS via Orphanet61 C0018922

Related Diseases for Hemangiopericytoma

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Diseases in the Hemangiopericytoma family:

Adult Malignant Hemangiopericytoma

Diseases related to Hemangiopericytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 187)
idRelated DiseaseScoreTop Affiliating Genes
1infantile myofibromatosis31.0DES
2fasciitis30.9ACTC1
3desmoplastic small round cell tumor30.8MUC1, DES
4glomus tumor30.7DES, VIM, ACTC1
5hemangioma30.6ACTC1, F13A1
6liposarcoma30.5VIM, DES
7fibrous meningioma30.5NF2, MUC1
8malignant peripheral nerve sheath tumor30.4VIM, NF2
9endometrial stromal sarcoma30.3DES, VIM, ACTC1
10angiosarcoma30.3VIM, MUC1, ACTC1
11rhabdomyosarcoma30.3DES, IGF2, VIM, ACTC1
12mesenchymal chondrosarcoma30.2DES, VIM, MUC1
13fibroma30.2DES, F13A1, VIM, ACTC1
14chondrosarcoma30.2MUC1, VIM, DES
15mesothelioma30.2DES, VIM, MUC1, ACTC1, NF2
16pleomorphic adenoma30.1ACTC1, MUC1, VIM, IGF2, DES
17adenocarcinoma30.1F13A1, VIM, MUC1, ACTC1, NF2
18fibrous histiocytoma30.0ACTC1, VIM, F13A1, DES
19dermatofibrosarcoma protuberans30.0DES, F13A1, VIM, MUC1, ACTC1
20leiomyoma29.9DES, IGF2, VIM, ACTC1
21gastrointestinal stromal tumor29.7DES, VIM, ACTC1, NF2
22sarcoma29.6DES, IGF2, F13A1, VIM, MUC1, ACTC1
23neurofibroma29.4NF2, ACTC1, MUC1, VIM, F13A1
24meninges hemangiopericytoma10.8
25meningitis10.7
26thyroiditis10.7
27hypoglycemia10.5
28syringoma10.5MUC1
29retroperitoneal hemangiopericytoma10.5
30adenomatoid tumor10.5VIM
31malignant peritoneal solitary fibrous tumor10.5
32malignant pleural solitary fibrous tumor10.5
33hidradenoma10.5MUC1
34cystadenocarcinoma10.5MUC1
35islet cell tumor10.4
36hypoglycemic coma10.4
37spindle cell lipoma10.4
38goiter10.4
39dedifferentiated liposarcoma10.4
40macular holes10.4PTGDS
41perineurioma10.4MUC1, VIM
42osteomalacia10.4
43mediastinitis10.4
44secretory meningioma10.4MUC1, VIM
45neurilemmoma10.3NF2
46clear cell ependymoma10.3MUC1, VIM
47choroid plexus papilloma10.3MUC1, IGF2
48insulin-like growth factor i10.3
49benign fibrous mesothelioma10.3
50tonsillitis10.3

Graphical network of the top 20 diseases related to Hemangiopericytoma:



Diseases related to hemangiopericytoma

Symptoms for Hemangiopericytoma

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HPO human phenotypes related to Hemangiopericytoma:

id Description Frequency HPO Source Accession
1 autosomal recessive inheritance HP:0000007
2 abnormality of the cardiovascular system HP:0001626

Drugs & Therapeutics for Hemangiopericytoma

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Drug clinical trials:

Search ClinicalTrials for Hemangiopericytoma

Search NIH Clinical Center for Hemangiopericytoma

Genetic Tests for Hemangiopericytoma

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Anatomical Context for Hemangiopericytoma

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MalaCards organs/tissues related to Hemangiopericytoma:

31
Bone, Lung, Breast, Liver, Tongue, Kidney, Pineal, Pituitary, Spleen, Heart, Ovary, Uterus, Spinal cord, Adipocyte, Skin, Eye, Brain, Smooth muscle, Small intestine, Colon, Salivary gland, Adrenal gland, Prostate, Testis, Trachea

Animal Models for Hemangiopericytoma or affiliated genes

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MGI Mouse Phenotypes related to Hemangiopericytoma:

35 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.8NF2, STAT6, MUC1, IGF2
2MP:00020068.6NF2, STAT6, MUC1, PTGDS
3MP:00053918.5IGF2, VIM, MUC1, STAT6, NF2
4MP:00107718.2IGF2, PTGDS, NAB2, MUC1, STAT6, NF2
5MP:00053868.0DES, IGF2, PTGDS, NAB2, VIM, NF2
6MP:00053887.8IGF2, F13A1, NAB2, VIM, STAT6, NF2
7MP:00053787.8IGF2, NAB2, VIM, STAT6, ACTC1, NF2
8MP:00053897.8IGF2, F13A1, NAB2, VIM, STAT6, NF2
9MP:00053857.5DES, IGF2, F13A1, VIM, ACTC1
10MP:00107686.4DES, IGF2, F13A1, PTGDS, NAB2, VIM
11MP:00053766.3NF2, DES, IGF2, F13A1, PTGDS, VIM

Publications for Hemangiopericytoma

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Articles related to Hemangiopericytoma:

(show top 50)    (show all 566)
idTitleAuthorsYear
1
Hemangiopericytoma of the spleen. (25638732)
2015
2
Intracranial infantile hemangiopericytoma. (24905842)
2014
3
Intradural extra medullary hemangiopericytoma of dorsal spine. (25059986)
2014
4
Diffuse hypopigmentation followed by hyperpigmentation in an african american woman with hemangiopericytoma treated with dasatinib. (25584281)
2014
5
Meningeal hemangiopericytoma and solitary fibrous tumors carry the NAB2-STAT6 fusion and can be diagnosed by nuclear expression of STAT6 protein. (23575898)
2013
6
Endoscopic Resection of Sinonasal Hemangiopericytoma following Preoperative Embolisation: A Case Report and Literature Review. (23738175)
2013
7
Clinical analysis of intracranial hemangiopericytoma. (24294454)
2013
8
Large hemangiopericytoma associated with arteriovenous malformations and dural arteriovenous fistulae. (22251512)
2011
9
Lipomatous hemangiopericytoma of the stomach: a case report and a review of literature. (22147987)
2011
10
Phase II study of subcutaneous octreotide in adults with recurrent or progressive meningioma and meningeal hemangiopericytoma. (21558077)
2011
11
Hemangiopericytoma in the trigone of the lateral ventricle. (21613766)
2011
12
Intradural hemangiopericytoma of the thoracic spine: a case report. (21641873)
2011
13
Hemangiopericytoma: collision with meningioma and recurrence. (20198500)
2010
14
Concurrent Cochlear Implantation with Resection of Skull Base Hemangiopericytoma following Sudden Deafness in an Only Hearing Ear. (21311622)
2010
15
Hemangiopericytoma-solitary fibrous tumour of soft tissue: description of a case showing atypical histological features. (20731251)
2010
16
Inhibiting the VEGF-VEGFR pathway in angiosarcoma, epithelioid hemangioendothelioma, and hemangiopericytoma/solitary fibrous tumor. (20485168)
2010
17
Intradural hemangiopericytoma of the lumbar spine: a rare entity. (18768724)
2009
18
A case of metastatic hemangiopericytoma occurring 16 years after initial presentation: with special reference to the clinical behavior and treatment of metastatic hemangiopericytoma. (19755799)
2009
19
Sudden death due to undiagnosed intracranial hemangiopericytoma. (18520488)
2008
20
Hemangiopericytoma of the Breast: A Case Report. (21048916)
2008
21
Pulmonary lipomatous hemangiopericytoma: report of a rare tumor and comparison with solitary fibrous tumor. (17455098)
2007
22
Metastatic hemangiopericytoma of the skin treated with wide local excision and MGN-3. (16393616)
2006
23
D2-40 staining in sinonasal-type hemangiopericytoma--further evidence of distinction from conventional hemangiopericytoma and solitary fibrous tumor. (16362413)
2006
24
Bone metastasis of intracranial meningeal hemangiopericytoma. (15990973)
2005
25
Preoperative embolization in surgical treatment of a primary hemangiopericytoma of the rib: a case report. (15832008)
2005
26
Case 3. Oncogenic osteomalacia associated with hemangiopericytoma localized by octreotide scan. (15908675)
2005
27
Multiple extracranial metastases from a meningeal hemangiopericytoma and severe hypoglycemia: a case report]. (15227844)
2004
28
Sinonasal-type hemangiopericytoma: a clinicopathologic and immunophenotypic analysis of 104 cases showing perivascular myoid differentiation. (12766577)
2003
29
Oncogenic hypophosphatemic osteomalacia associated with a nasal hemangiopericytoma. (17043447)
2003
30
Solitary fibrous tumor of the oral mucosa--morphological and immunohistochemical profile in the differential diagnosis with hemangiopericytoma. (12676265)
2003
31
Cutaneous malignant hemangiopericytoma with unusual clinical behavior. (12081167)
2002
32
Case of primary malignant hemangiopericytoma of the heart expressing basement membrane-degradable enzymes. (12366815)
2002
33
Hemangiopericytoma of the parotid gland: CT and MR features. (11419156)
2001
34
Intraocular hemangiopericytoma. A case report. (11528266)
2001
35
Preoperative embolization in surgical treatment of mediastinal hemangiopericytoma. (10750792)
2000
36
Liver angiosarcoma and hemangiopericytoma after occupational exposure to vinyl chloride monomer. (10964802)
2000
37
Fine-needle aspiration cytology of hemangiopericytoma: report of two cases. (10945907)
2000
38
Hemangiopericytoma in children and infants. (10618624)
2000
39
Positron emission tomography in a case of intracranial hemangiopericytoma. (10348440)
1999
40
Cytogenetic, ras, and p53: studies in cases of canine neoplasms (hemangiopericytoma, mastocytoma, histiocytoma, chloroma). (9987918)
1999
41
Oncogenic osteomalacia secondary to a hemangiopericytoma of the hip: case report. (10047746)
1999
42
Hepatic and pulmonary metastases from a meningeal hemangiopericytoma and severe hypoglycemia due to abnormal secretion of insulin-like growth factor: a case report. (10326704)
1999
43
Hemangiopericytoma of the third ventricle. Case report. (9950509)
1999
44
Long-term survival after repetitive surgery for malignant hemangiopericytoma of the lung with subsequent systemic metastases: case report and review of the literature. (9477464)
1997
45
Primary orbital hemangiopericytoma: a case report. (9294920)
1997
46
Meningeal hemangiopericytoma metastatic to the heart. (8776772)
1996
47
Hemangiopericytoma of the masticator space. (8659939)
1996
48
Hemangiopericytoma of the uterus: an unusual cause of the postmenopausal metrorrhagia. (7572113)
1995
49
Giant retroperitoneal hemangiopericytoma. (7494778)
1995
50
Hemangiopericytoma of the uterus vs. hemangiopericytoma-like endometrial stromal sarcoma: a histopathological approach to differential diagnosis. (4054418)
1985

Variations for Hemangiopericytoma

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Expression for genes affiliated with Hemangiopericytoma

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Search GEO for disease gene expression data for Hemangiopericytoma.

Pathways for genes affiliated with Hemangiopericytoma

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Pathways related to Hemangiopericytoma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Signaling by Aurora kinases36
Aurora C signaling36
9.7VIM, DES
29.4ACTC1, IGF2
3
Show member pathways
9.1ACTC1, VIM, DES
4
Show member pathways
8.6DES, IGF2, VIM, MUC1, STAT6
58.5NF2, ACTC1, VIM, DES

Compounds for genes affiliated with Hemangiopericytoma

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Compounds related to Hemangiopericytoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 67)
idCompoundScoreTop Affiliating Genes
1eosin4310.0MUC1, VIM
2toluidine439.9VIM, DES
3phalloidin439.7VIM, DES
44-hydroxytamoxifen439.7STAT6, VIM, IGF2
5adriamycin439.6MUC1, VIM, DES
6acetone439.6IGF2, MUC1
7azathioprine43 2 49 1212.6VIM, IGF2, DES
8hyaluronic acid43 2410.6MUC1, VIM, DES
9hydrocortisone43 2 59 1212.5IGF2, VIM, MUC1
10orcein439.5ACTC1, VIM, DES
11folate439.4IGF2, VIM, MUC1
12methotrexate49 43 1211.4STAT6, MUC1, VIM
132-methoxyethanol439.4ACTC1, VIM, IGF2
14imatinib43 49 1211.3DES, IGF2, ACTC1
15progestin439.3DES, IGF2, VIM, MUC1
16chloramphenicol43 2 49 1212.3IGF2, VIM, MUC1
17dihydrotestosterone43 28 24 1212.3DES, IGF2, VIM, MUC1
18estradiol43 24 1211.2DES, IGF2, VIM, MUC1
19retinoid439.2STAT6, VIM, PTGDS
20silver439.1PTGDS, F13A1, DES
21histamine43 28 2411.1IGF2, PTGDS, VIM, STAT6
22mucicarmine439.1DES, VIM, MUC1, ACTC1
23agar439.1NF2, MUC1, VIM, IGF2
24biotin43 24 1211.1ACTC1, MUC1, VIM, DES
25formaldehyde43 2410.1DES, VIM, MUC1, ACTC1
26cycloheximide439.0STAT6, VIM, PTGDS, IGF2
27actinomycin d439.0DES, IGF2, VIM, MUC1, STAT6
28steroid439.0ACTC1, STAT6, IGF2, DES
29heparin43 28 24 1211.7DES, IGF2, F13A1, VIM
30matrigel438.7ACTC1, MUC1, VIM
31cysteine438.7DES, IGF2, VIM, MUC1, NF2
32glycogen43 249.7DES, IGF2, VIM, MUC1, ACTC1
33dexamethasone43 49 28 1211.7IGF2, VIM, MUC1, STAT6, ACTC1
34procollagen438.6ACTC1, VIM, F13A1, DES
35oligonucleotide438.6IGF2, F13A1, VIM, STAT6
36iron43 249.6DES, F13A1, VIM, ACTC1
37serine438.4DES, IGF2, VIM, MUC1, STAT6, NF2
38s 100438.3ACTC1, MUC1, VIM, F13A1, DES
39reticulin438.3DES, F13A1, VIM, MUC1, ACTC1
40b 723438.3DES, F13A1, VIM, MUC1, ACTC1
41hematoxylin438.3DES, F13A1, VIM, MUC1, ACTC1
42tyrosine438.2DES, IGF2, MUC1, STAT6, ACTC1, NF2
43creatinine438.2DES, IGF2, PTGDS, VIM, MUC1, ACTC1
44testosterone43 59 24 1211.2DES, IGF2, PTGDS, VIM, MUC1, ACTC1
45retinoic acid43 248.9DES, IGF2, PTGDS, VIM, MUC1, STAT6
46calcium43 49 24 1210.7DES, F13A1, PTGDS, MUC1, STAT6, ACTC1
47vegf437.6DES, IGF2, F13A1, NAB2, VIM, MUC1
48paraffin437.4DES, IGF2, F13A1, VIM, MUC1, ACTC1
49progesterone43 28 59 24 1211.4DES, IGF2, F13A1, VIM, MUC1, ACTC1
50estrogen437.4DES, IGF2, F13A1, PTGDS, VIM, MUC1

GO Terms for genes affiliated with Hemangiopericytoma

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Cellular components related to Hemangiopericytoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:00310939.2F13A1, IGF2

Biological processes related to Hemangiopericytoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:00300499.1ACTC1, VIM, DES

Products for genes affiliated with Hemangiopericytoma

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Sources for Hemangiopericytoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet