MCID: HMN013
MIFTS: 58

Hemangiopericytoma malady

Summaries for Hemangiopericytoma

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8Disease Ontology, 42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Hemangiopericytoma is a term used to described a group of tumors that are derived from pericytes, the cells normally arranged along specific types of blood vessels called capillaries and venules. these types of tumors are typically slow-growing, may be either benign (non-cancerous) or malignant (cancerous), and may occur anywhere in the body. last updated: 11/19/2013

MalaCards: Hemangiopericytoma, also known as hemangiopericytoma, malignant, is related to meningioma and sarcoma. An important gene associated with Hemangiopericytoma is DES (desmin), and among its related pathways are Striated Muscle Contraction and EGFR Signaling Pathway. The compounds estrogen and glycogen have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and breast, and related mouse phenotypes are reproductive system and embryogenesis.

Disease Ontology:8 A soft tissue cancer that is a soft tissue sarcoma and originates in the pericytes in the walls of capillaries.

Wikipedia:63 A hemangeopericytoma (HPC) is a type of soft tissue sarcoma that originates in the pericytes in the... more...

Aliases & Classifications for Hemangiopericytoma

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
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Aliases & Descriptions:

hemangiopericytoma 8 42 10 44 60
hemangiopericytoma, malignant 8 60
haemangiopericytic meningioma 8
malignant hemangiopericytoma 8


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Disease Ontology8 DOID:264
MeSH34 D006393
SNOMED-CT56 134335004, 36060005
NCIt39 C3087

Related Diseases for Hemangiopericytoma

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17GeneCards, 18GeneDecks
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Diseases in the Hemangiopericytoma family:

Adult Malignant Hemangiopericytoma

Diseases related to Hemangiopericytoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 229)
idRelated DiseaseScoreTop Affiliating Genes
1meningioma30.5PTGDS, EPB41L3, CD34, MUC1, IGF2, NF2
2sarcoma30.4ACTC1, CD34, MUC1, IGF2, NF2, SSX2
3glomus tumor30.3ACTC1, DES, S100A1, VIM
4synovial sarcoma30.2CDH1, MUC1, IGF2, SSX2, DES, MDM2
5pituitary adenoma30.1RB1, MGMT, E2F1
6liposarcoma30.1CD34, DES, RB1, MDM2, VIM
7adenoma30.1ACTC1, CDH1, MUC1, IGF2, RB1, MGMT
8hemangioblastoma30.0MUC1, S100B
9fibrous meningioma30.0MUC1, NF2, S100B
10endometrial stromal sarcoma30.0ACTC1, DES, VIM
11angiosarcoma30.0ACTC1, CD34, MUC1, VIM
12benign meningioma30.0EPB41L3, NF2, MDM2
13fibrous histiocytoma30.0ACTC1, CD34, DES, F13A1, S100B, VIM
14seminoma29.7IGF2, SSX2
15mesenchymal chondrosarcoma29.7MUC1, DES, VIM
16lipoma29.7CD34, DES, MDM2, S100A1
17neurofibromatosis29.7NGFR, NF2, S100B
18retinoblastoma29.7NGFR, RB1, MDM2, E2F1
19smooth muscle tumor29.7ACTC1, IGF2, DES, S100A1, S100B, VIM
20giant cell tumor29.7ACTC1, MUC1, DES, F13A1, S100B, VIM
21papillary carcinoma29.7ACTC1, CDH1, MUC1, E2F1, S100A1
22leiomyoma29.7ACTC1, CD34, IGF2, DES, S100A1, S100B
23chondrosarcoma29.7MUC1, DES, MDM2, E2F1, S100A1, S100B
24gastrointestinal stromal tumor29.7ACTC1, CD34, NF2, DES, E2F1, S100A1
25neurofibroma29.7ACTC1, CD34, MUC1, NGFR, NF2, F13A1
26transitional cell carcinoma29.7CDH1, RB1, MDM2
27meninges hemangiopericytoma10.7
28meningitis10.7
29hypoglycemia10.5
30retroperitoneal hemangiopericytoma10.4
31breast hemangiopericytoma10.4
32kidney hemangiopericytoma10.4
33osteomalacia10.3
34mediastinitis10.3
35hepatitis10.3
36heart malignant hemangiopericytoma10.2
37malignant mediastinum hemangiopericytoma10.2
38conventional malignant hemangiopericytoma10.2
39childhood malignant hemangiopericytoma10.1
40adult intracranial malignant hemangiopericytoma10.1
41hepatitis a10.1
42adult malignant hemangiopericytoma10.1
43cervicitis10.1
44histiocytoma10.1
45pancreatitis10.1
46peritonitis10.1
47intracranial embolism10.0
48trigonitis10.0
49arteriovenous malformation10.0
50cerebritis10.0

Graphical network of the top 20 diseases related to Hemangiopericytoma:



Diseases related to hemangiopericytoma

Clinical Features for Hemangiopericytoma

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Drugs & Therapeutics for Hemangiopericytoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Hemangiopericytoma

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Anatomical Context for Hemangiopericytoma

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32MalaCards
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MalaCards organs/tissues related to Hemangiopericytoma:

32
Bone, Lung, Breast, Liver, Tongue, Pituitary, Kidney, Ovary, Pineal, Heart, Uterus, Spleen, Spinal cord, Adipocyte, Skin, Trachea, Testis, Prostate, Small intestine, Brain, Adrenal gland, Salivary gland, Smooth muscle, Colon, Eye

Animal Models for Hemangiopericytoma or affiliated genes

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36MGI
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Publications for Hemangiopericytoma

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50PubMed
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Articles related to Hemangiopericytoma:

(show top 50)    (show all 532)
idTitleAuthorsYear
1
Hemangiopericytoma of the larynx. (22341336)
2013
2
Optic nerve meningeal hemangiopericytoma: a clinicopathologic case report. (23294915)
2013
3
Hemangiopericytoma invading the craniovertebral junction: First reported case and review of the literature. (24381454)
2013
4
A case of hemangiopericytoma of the soft palate with articulate disorder and dysphagia. (23703709)
2013
5
Juvenile anaplastic hemangiopericytoma of cavernous sinus. (23560021)
2012
6
Pelvic hemangiopericytoma: the role of diffusion weighted imaging in targeting the biopsy site and in monitoring the tumour response to radiotherapy. (22933930)
2011
7
Hemangiopericytoma: long-term outcome revisited. Clinical article. (20672899)
2011
8
Endovascular embolization of cervical hemangiopericytoma with Onyx-18: case report and review of the literature. (21990849)
2011
9
A clinicopathological and immunohistochemical study of central nervous system hemangiopericytomas. (20167500)
2010
10
Hemangiopericytoma arising in the body of the lateral ventricle. (19730782)
2010
11
A case of metastatic hemangiopericytoma occurring 16 years after initial presentation: with special reference to the clinical behavior and treatment of metastatic hemangiopericytoma. (19755799)
2009
12
Isolation of Bartonella vinsonii subsp. berkhoffii genotype II from a boy with epithelioid hemangioendothelioma and a dog with hemangiopericytoma. (19369441)
2009
13
Primary hemangiopericytoma of the liver: sonographic findings. (19253347)
2009
14
Hypoglycemia from IGF2 overexpression associated with activation of fetal promoters and loss of imprinting in a metastatic hemangiopericytoma. (19383775)
2009
15
Non-adenomatous non-epithelial carcinoma (hemangiopericytoma) of prostate treated with conservative surgery followed by adjuvant chemoradiation. (19672428)
2009
16
Gastrointestinal stromal tumor in the duodenum exhibiting hemangiopericytoma-like histological pattern. (19154263)
2009
17
Sequential salvage chemotherapy for recurrent intracranial hemangiopericytoma. (18981882)
2008
18
Pulmonary lipomatous hemangiopericytoma: report of a rare tumor and comparison with solitary fibrous tumor. (17455098)
2007
19
Recurrent intracranial solitary fibrous tumor initially diagnosed as hemangiopericytoma. (18095142)
2007
20
Lipomatous hemangiopericytoma of the skull base and parapharyngeal space. (16791050)
2006
21
Primary mediastinal hemangiopericytoma. (16643656)
2006
22
Case 3. Oncogenic osteomalacia associated with hemangiopericytoma localized by octreotide scan. (15908675)
2005
23
Multiple extracranial metastases from a meningeal hemangiopericytoma and severe hypoglycemia: a case report]. (15227844)
2004
24
Sinonasal hemangiopericytoma. (15577808)
2004
25
Recurrent intracranial hemangiopericytoma with extracranial and unusual multiple metastases: case report and review of the literature. (15237597)
2004
26
Hypoglycemia associated with the production of insulin-like growth factor (IGF)-II by a hemangiopericytoma]. (12571793)
2003
27
Cross-sectional imaging of primary osseous hemangiopericytoma. (11868080)
2002
28
Primary epidural hemangiopericytoma in the lumbar spine: a case report. (11923676)
2002
29
Orbital hemangiopericytoma and solitary fibrous tumor: a morphologic continuum. (12574845)
2001
30
Duodenal hemangiopericytoma: CT and MRI findings. (11483418)
2001
31
Case report of a newborn with a posterior thoracic midline congenital hemangiopericytoma of the back. (10917311)
2000
32
Hemangiopericytoma of greater omentum. (10659488)
2000
33
Hepatic and pulmonary metastases from a meningeal hemangiopericytoma and severe hypoglycemia due to abnormal secretion of insulin-like growth factor: a case report. (10326704)
1999
34
MR appearance of pelvic hemangiopericytoma. (9933402)
1999
35
Hemangiopericytoma of the nose: a case for both internal and external localization. (10216482)
1999
36
Lipomatous hemangiopericytoma: a morphologically distinct soft tissue tumor. (10506450)
1999
37
Giant retroperitoneal hemangiopericytoma with paraneoplastic gynecomastia. Case report and literature review. (10567888)
1999
38
Congenital nasal hemangiopericytoma: intrauterine, intraoperative, and histologic findings. (10378528)
1999
39
Fine-needle aspiration cytology of malignant hemangiopericytoma of the salivary gland: A case report. (10572271)
1999
40
Hemangiopericytoma of the breast: mammographic and sonographic findings. (9580194)
1998
41
Pneumothorax due to hemangiopericytoma metastasis from the thigh. (9720371)
1998
42
Infantile hemangiopericytoma of the musculoskeletal system: case report and literature review. (9600564)
1998
43
Temporal bone hemangiopericytoma. (8643276)
1996
44
Hemangiopericytoma of the inner canthus. (8604742)
1996
45
Resection of primary pulmonary hemangiopericytoma: a report of two cases. (8845617)
1996
46
Giant retroperitoneal hemangiopericytoma. (7494778)
1995
47
Hemangiopericytoma: histopathological pattern or clinicopathologic entity? (8545589)
1995
48
Hemangiopericytoma of the skull base and Collet-Sicard syndrome: a case report. (8556985)
1995
49
The immunophenotype of hemangiopericytomas and glomus tumors, with special reference to muscle protein expression: an immunohistochemical study and review of the literature. (1708501)
1991
50
Preoperative vascular embolization as an adjunct to successful resection of large retroperitoneal hemangiopericytoma. (765503)
1976

Genetic Variations for Hemangiopericytoma

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Expression for genes affiliated with Hemangiopericytoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hemangiopericytoma

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Pathways for genes affiliated with Hemangiopericytoma

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37NCBI BioSystems Database, 53Reactome, 55SinoBiological, 12EMD Millipore, 29KEGG, 51QIAGEN, 4Cell Signaling Technology
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Compounds for genes affiliated with Hemangiopericytoma

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44Novoseek, 24HMDB, 49PharmGKB, 59Tocris Bioscience, 11DrugBank, 28IUPHAR, 2BitterDB
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Compounds related to Hemangiopericytoma according to GeneCards/GeneDecks:

(show top 50)    (show all 114)
idCompoundScoreTop Affiliating Genes
1estrogen4410.8F13A1
2glycogen44 2411.6IGF2, ACTC1, MDM2
3reticulin4410.6VIM, DES, MUC1, ACTC1
4orcein4410.5VIM, ACTC1, S100B, DES
5creatinine4410.4ACTC1, CDH1, IGF2, PTGDS
62-methoxyethanol4410.4S100A1, VIM, IGF2, ACTC1
7s 1004410.3VIM, F13A1, DES, MUC1, ACTC1, S100B
8mucicarmine4410.3S100B, VIM, DES, MUC1, S100A1, ACTC1
9etoposide44 49 59 1113.2S100B, VIM, RB1, IGF2, CDH1, MDM2
10biotin44 11 2412.2ACTC1, MUC1, DES, RB1, VIM, S100A1
11progestin4410.2VIM, DES, CDH1, MUC1, IGF2
12dexamethasone44 49 28 1113.2MGMT, S100B, CDH1, IGF2, RB1, MDM2
13serine4410.2S100B, NF2, CDH1, DES, E2F1
14p0024410.2CDH1, MGMT, MDM2, RB1, IGF2, DES
15silver4410.2S100A1, PTGDS, F13A1, CDH1, DES, CD34
16paclitaxel44 49 1112.2MDM2, S100B, CDH1, IGF2, E2F1, RB1
17adriamycin4410.1VIM, E2F1, MDM2, RB1, DES, MUC1
18thymidylate4410.1MDM2, MGMT, E2F1, RB1, VIM, CDH1
19b 7234410.1MUC1, CDH1, ACTC1, DES, VIM, S100B
20formaldehyde44 2411.1MUC1, ACTC1, VIM, S100B, MGMT, RB1
215-aza-2deoxycytidine4410.0SSX2, MGMT, CDH1, MDM2, EPB41L3, IGF2
22azathioprine44 49 2 1113.0VIM, DES, IGF2, MGMT, CDH1
23methotrexate44 49 1112.0MUC1, RB1, MDM2, MGMT, VIM, CDH1
245fluorouracil4410.0RB1, CDH1, MGMT, MDM2, E2F1, IGF2
25chloramphenicol44 2 1112.0MUC1, MGMT, VIM, S100B, E2F1, IGF2
26vincristine44 49 1112.0RB1, MGMT, E2F1, VIM
27actinomycin d4410.0RB1, DES, IGF2, MUC1, E2F1, VIM
28estradiol44 11 2412.0MDM2, RB1, DES, IGF2, MUC1, E2F1
29rapamycin4410.0MDM2, E2F1, NF2, IGF2, CDH1, VIM
30steroid4410.0ACTC1, DES, NGFR, MDM2, RB1, E2F1
31doxorubicin44 49 1112.0MGMT, VIM, CDH1, E2F1, DES, RB1
3212-o-tetradecanoylphorbol 13-acetate449.9CD34, CDH1, MUC1, NGFR, DES, RB1
33calcium44 49 11 2412.9ACTC1, S100B, MUC1, NGFR, DES, F13A1
34cyclic amp44 2410.9RB1, VIM, CDH1, MUC1, NGFR, DES
35matrigel449.9ACTC1, CDH1, MUC1, NGFR, RB1, VIM
36hematoxylin449.9VIM, S100B, S100A1, F13A1, DES, NGFR
37iron44 2410.9F13A1, S100A1, DES, ACTC1, MDM2, S100B
38oligonucleotide449.8VIM, MGMT, E2F1, MDM2, RB1, F13A1
39agar449.8VIM, MDM2, RB1, NF2, IGF2, NGFR
40nitric oxide44 11 2411.8MGMT, NGFR, E2F1, MDM2, MUC1, DES
41testosterone44 59 11 2412.7MUC1, ACTC1, VIM, PTGDS, S100B, RB1
42crcs449.7MUC1, RB1, MGMT, CDH1
43thymidine44 2410.7MGMT, EPB41L3, DES, NGFR, RB1, MDM2
44cysteine449.6MDM2, NF2, IGF2, VIM, NGFR, MUC1
45cisplatin44 49 59 1112.6RB1, MDM2, MGMT, E2F1, MUC1, IGF2
46tyrosine449.4DES, RB1, E2F1, S100A1, MDM2, NF2
47vegf449.4IGF2, DES, F13A1, RB1, MDM2, MGMT
48retinoic acid44 2410.4VIM, MUC1, CDH1, S100B, S100A1, E2F1
49paraffin449.3MGMT, MDM2, RB1, F13A1, DES, NF2
50progesterone44 59 28 11 2413.0MDM2, MGMT, E2F1, S100A1, S100B, VIM

GO Terms for genes affiliated with Hemangiopericytoma

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16Gene Ontology
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Cellular components related to Hemangiopericytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Rb-E2F complexGO:0351899.9RB1, E2F1
2perinuclear region of cytoplasmGO:0484719.9PTGDS, CD34, CDH1, NF2, S100B

Biological processes related to Hemangiopericytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of transcription involved in G1/S transition of mitotic cell cycleGO:07193010.3RB1, E2F1
2regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:04328110.3CDH1, NGFR, MGMT
3negative regulation of cell-cell adhesionGO:02240810.2CDH1, NF2
4muscle filament slidingGO:03004910.2ACTC1, DES, VIM
5cellular response to hypoxiaGO:07145610.0S100B, E2F1, MDM2
6response to drugGO:0424939.7ACTC1, CDH1, MDM2, MGMT

Molecular functions related to Hemangiopericytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:00520010.2EPB41L3, DES, VIM
2S100 protein bindingGO:0445489.9S100A1, S100B
3identical protein bindingGO:0428029.8DES, RB1, MDM2, S100A1, S100B, VIM
4protein bindingGO:0055158.9MDM2, E2F1, S100A1, S100B, VIM, RB1

Products for genes affiliated with Hemangiopericytoma

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Sources for Hemangiopericytoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet