MCID: HMR002
MIFTS: 51

Hemarthrosis malady

Bone diseases category

Summaries for Hemarthrosis

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66Wikipedia, 34MalaCards
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Wikipedia:66 Hemarthrosis (or haemarthrosis, plural h(a)emarthroses) is a bleeding into joint spaces. more...

MalaCards: Hemarthrosis, also known as hemarthrosis involving pelvic region and thigh, is related to arthropathy and factor x deficiency. An important gene associated with Hemarthrosis is F9 (coagulation factor IX), and among its related pathways are PTM- gamma carboxylation, hypusine formation and arylsulfatase activation and Response to elevated platelet cytosolic Ca2+. The compounds recombinate and kogenate have been mentioned in the context of this disorder. Affiliated tissues include bone, skeletal muscle and myeloid, and related mouse phenotype homeostasis/metabolism.

Aliases & Classifications for Hemarthrosis

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Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 59SNOMED-CT, 28ICD9CM, 36MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases


Aliases & Descriptions:

hemarthrosis 9 11 46 63
hemarthrosis involving pelvic region and thigh 9
haemarthrosis of the pelvic region and thigh 9
hemarthrosis of the pelvic region and thigh 9
hemarthrosis involving shoulder region 9
hemarthrosis involving ankle and foot 9
hemarthrosis of the ankle and/or foot 9
hemarthrosis of the shoulder region 9
haemarthrosis of the ankle and foot 9
hemarthrosis of the ankle and foot 9
hemarthrosis of ankle and/or foot 9
hemarthrosis involving lower leg 9
hemarthrosis involving upper arm 9
hemarthrosis of shoulder region 9
haemarthrosis of shoulder joint 9
hemarthrosis involving forearm 9
hemarthrosis of the upper arm 9
hemarthrosis of the lower leg 9
hemarthrosis involving hand 9
hemarthrosis of the forearm 9
hemarthrosis of upper arm 9
hemarthrosis of lower leg 9
hemarthrosis of the hand 9
hemarthrosis of shoulder 9
hemarthrosis of forearm 9
hemarthrosis of hand 9


External Ids:

Disease Ontology9 DOID:801
ICD9CM28 719.1, 719.10
MeSH36 D006395

Related Diseases for Hemarthrosis

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Hemarthrosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 99)
idRelated DiseaseScoreTop Affiliating Genes
1arthropathy30.2F8, F9
2factor x deficiency30.1F9, F10, F3
3factor xi deficiency30.1F3, F9, F8
4acute myocardial infarction30.1F3, F10, VWF
5glanzmann's thrombasthenia30.0VWF
6myocardial infarction30.0F10, F3, F8, VWF, F9
7amyloidosis29.9F10, F9
8hemophilia b29.8F3, F8, F10, F9
9systemic lupus erythematosus29.8VWF, F10, F3, F8
10hemorrhagic disease29.8F3, VWF, F8, F9, F10
11hemophilia10.5
12synovitis10.3
13arthritis10.3
14scurvy10.2
15thrombasthenia10.2
16aneurysm10.2
17cardiac tamponade10.1F8
18thrombophlebitis10.1F8
19angiodysplasia10.1VWF
20carotid artery thrombosis10.1F3
21pigmented villonodular synovitis10.1
22villonodular synovitis10.1
23osteoarthritis10.1
24lipoma10.1
25purpura10.1
26acquired hemophilia10.1
27blindness10.1
28factor v deficiency10.1F3, F8
29protein s deficiency10.0F8, F3
30peripheral vascular disease10.0VWF, F3
31viral hepatitis10.0F10, F8
32sickle cell disease10.0VWF, F9
33coronary thrombosis10.0F3, VWF
34bladder carcinoma10.0F9, F10
35stroke, ischemic10.0VWF, F3
36hypercholesterolemia10.0F8, F10, F9
37pulmonary embolism10.0F10, F9, F3
38factor viii deficiency10.0F3, F9, F8
39hemolytic anemia10.0VWF, F3
40hepatitis10.0F8, F10, F9
41bernard-soulier syndrome10.0VWF, F9, F8
42hyperhomocysteinemia10.0F8, F9, VWF
43factor xii deficiency10.0F3, F13B
44hypothyroidism10.0F9, F8, VWF
45blood platelet disease10.0F8, F10, VWF
46pregnancy loss10.0F3, F10, F8
47liver cirrhosis10.0F3, F9, F10
48sepsis10.0F9, F10, F3
49thrombocytosis10.0F3, F10, VWF
50connective tissue disease10.0F3, VWF

Graphical network of the top 20 diseases related to Hemarthrosis:



Diseases related to hemarthrosis

Symptoms for Hemarthrosis

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Drugs & Therapeutics for Hemarthrosis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Hemarthrosis

Drug clinical trials:

Search ClinicalTrials for Hemarthrosis

Search NIH Clinical Center for Hemarthrosis

Search CenterWatch for Hemarthrosis

Genetic Tests for Hemarthrosis

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Anatomical Context for Hemarthrosis

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34MalaCards
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MalaCards organs/tissues related to Hemarthrosis:

34
Bone, Skeletal muscle, Myeloid, Monocytes, B cells

Animal Models for Hemarthrosis or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Hemarthrosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.9F8, F3, F10, F9, VWF

Publications for Hemarthrosis

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Sources:
53PubMed
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Articles related to Hemarthrosis:

(show top 50)    (show all 205)
idTitleAuthorsYear
1
Hemarthrosis in hemophilic mice results in alterations in M1-M2 monocyte/macrophage polarization. (24252538)
2013
2
Recurrent hemarthrosis : an unusual cause. (23680622)
2013
3
Antiplasmin, but not amiloride, prevents synovitis and cartilage damage following hemarthrosis in hemophilic mice. (24283895)
2013
4
Knee hemarthrosis after arthroscopic surgery in an athlete with low factor XIII activity. (23031577)
2012
5
Spontaneous recurrent hemarthrosis of the knee joint in the elderly: a report of two cases. (21607723)
2012
6
MRI findings in adolescent patients with acute traumatic knee hemarthrosis. (23147616)
2012
7
Intra-articular nodular fasciitis of the knee: a rare cause of recurrent hemarthrosis. (21431289)
2012
8
A rare case of meniscal hematoma with hemarthrosis of the knee: a case report. (21938355)
2011
9
Glanzmann thrombasthenia detected because of knee hemarthrosis: a case report. (20736850)
2010
10
Hemarthrosis due to a rare cause of hemorrhagic diathesis: Ehlers-Danlos syndrome. (18432503)
2008
11
A case of delayed recurrent hemarthrosis after posterolateral reconstruction of the knee with a staple fixation at the lateral femoral epicondyle. (18365223)
2008
12
Embolization of spontaneous hemarthrosis post total knee replacement. (18185956)
2008
13
In vitro multipotentiality and characterization of human unfractured traumatic hemarthrosis-derived progenitor cells: A potential cell source for tissue repair. (17171634)
2007
14
Recurrent hemarthrosis after knee joint arthroplasty: etiology and treatment. (14973857)
2004
15
Hemarthrosis and scurvy. (12180758)
2002
16
Yersinia enterocolitica O:3 infection of a prosthetic knee joint related to recurrent hemarthrosis. (11928845)
2002
17
Spontaneous hemarthrosis 6 years after total knee arthroplasty. (11172285)
2001
18
Hemarthrosis as initial presentation of scurvy. (11508601)
2001
19
Cytogenetic studies in patients with hemophilic hemarthrosis treated by 198Au, 186Rh, and 90Y radioactive synoviorthesis. (10647112)
2000
20
Recurrent spontaneous hemarthrosis associated with reflex sympathetic dystrophy. (9523789)
1998
21
Hemarthrosis and hip joint pressure in femoral neck fractures. (9728169)
1998
22
Hemarthrosis and tourniquet use. (9728713)
1998
23
Recurrent acute hemarthrosis after anterior cruciate ligament reconstruction. Report of an unusual complication and a review of the literature. (8739716)
1996
24
Cuff tear arthropathy with hemarthrosis. A report on 3 elderly patients. (9065069)
1996
25
Recurrent hemarthrosis following a total knee arthroplasty. (8776057)
1995
26
Recurrent spontaneous hemarthrosis nine years after a total knee arthroplasty. A presentation with pigmented villonodular synovitis. (8501094)
1993
27
Acute traumatic knee hemarthrosis. (8461076)
1993
28
Recurrent hemarthrosis associated with gout. (1555350)
1992
29
Reduction and osteosynthesis of subcapital fractures of the femoral neck: possible repercussions on post-fracture hemarthrosis of the hip. (1345649)
1992
30
Hemarthrosis in patients with acquired factor VIII inhibitor. (1902518)
1991
31
Hemarthrosis of the ankle secondary to false aneurysm caused by impingement from an osteophyte. A case report. (2745490)
1989
32
Late hemarthrosis from a threaded acetabular component. (3361321)
1988
33
Hemarthrosis after femoral neck fracture fixation. (3188856)
1988
34
The significance of hemarthrosis of the knee in children. (3358674)
1988
35
Spontaneous hemarthrosis associated with an exostosis of the talus. (3572920)
1987
36
Differentiating pyogenic arthritis from spontaneous hemarthrosis in patients with hemophilia. (3953068)
1986
37
Intracapsular pressure and hemarthrosis following femoral neck fracture. (6692612)
1984
38
The presence of siderosomes in synovioblasts (B cells) of chronic spontaneous hemarthrosis. Histologic, electron microscopic, and roentgenographic electron microanalysis studies of three cases. (6548901)
1984
39
Hemarthrosis in an heparinized patient. (856220)
1977
40
Letter: Hemarthrosis secondary to heparin therapy. (962976)
1976
41
On the pathogenesis of hemophilic hemarthrosis]. (808446)
1975
42
Hemarthrosis. (1053879)
1975
43
Management of hemarthrosis. (5440065)
1970
44
Double-blind studies on the use of steroids in the treatment of acute hemarthrosis in patients with hemophilia. (4907066)
1970
45
Chronic myeloid leukemia with hemarthrosis. A case report. (5231484)
1967
46
Experimental hemarthrosis. The response of canine knees to injections of autologous blood. (6018731)
1967
47
Hemarthrosis complicating anticoagulant therapy. Report of three cases. (5952425)
1966
48
Experimental hemarthrosis: the removal of chromium-51- and iron-59-labeled erythrocytes injected into the knee joint of rabbit and man. (14438187)
1960
49
Some observations on experimental hemarthrosis and the pathogenesis of hemophilic arthritis. (14438188)
1959
50
The use of hyaluronidase in the treatment of acute hemophilic hemarthrosis. (13035639)
1953

Variations for Hemarthrosis

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Expression for genes affiliated with Hemarthrosis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hemarthrosis

Search GEO for disease gene expression data for Hemarthrosis.

Pathways for genes affiliated with Hemarthrosis

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Sources:
51PathCards, 56Reactome, 52PharmGKB, 39NCBI BioSystems Database, 13EMD Millipore, 54QIAGEN, 31KEGG, 55R&D Systems
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Pathways related to Hemarthrosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7F10, F9
2
Show member pathways
9.5VWF, F8
39.4F13B, F8
4
Show member pathways
7.8F9, F3, F10, F8, F13B
5
Show member pathways
Complement Activation, Classical Pathway39
Complement and Coagulation Cascades39
7.3F3, F10, F13B, F9, VWF, F8
6
Show member pathways
7.3F8, F3, F10, F13B, F9, VWF
7
Show member pathways
7.3F13B, F9, F3, F8, VWF, F10

Compounds for genes affiliated with Hemarthrosis

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Sources:
46Novoseek, 52PharmGKB, 12DrugBank, 3BitterDB, 25HMDB, 62Tocris Bioscience, 30IUPHAR
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Compounds related to Hemarthrosis according to GeneCards/GeneDecks:

(show top 50)    (show all 103)
idCompoundScoreTop Affiliating Genes
1recombinate469.8F8, VWF
2kogenate469.8VWF, F8
3echicetin469.6F9, VWF
4tributylphosphate469.6F8, VWF, F9
5roxifiban469.5F3, F10
6ivig469.4F9, F8, VWF
7efegatran469.4F10, F3
8desirudin469.3F10, F3
9organon469.3F10, F9, F3
10fondaparinux469.3F9, F10, F3
11rituximab46 52 1211.3VWF, F9, F8
12coumarins469.3F9, F3, F10
13ecarin469.2F3, F10
14gamma-carboxyglutamic acid469.2F3, F9, F10
15coumarin46 3 52 2512.2F3, F9, F10
16rfviii469.2F9, VWF, F8, F10
17dextran sulfate469.2F3, F10, F9
18dabigatran52 4610.1F3, F10
19tinzaparin46 1210.1F10, VWF, F3
20acetaminophen46 3 52 25 1213.1F8, F9, F10, VWF
21ppack469.1F10, F3, VWF
22cardiolipin46 1210.1F10, F8, F3
23tirofiban46 1210.1F10, F3, VWF
24abciximab46 1210.1VWF, F10, F3
25hydroxyethyl starch469.1VWF, F8, F3
26clopidogrel46 52 25 1212.1VWF, F3, F10
27kininogen469.0F9, F3, VWF
28guanidine hydrochloride468.9F3, VWF, F10
29kaolin468.9F3, F9, F10, F8
30cacl2468.9F3, F10, F8, F9
31dermatan sulfate468.8F10, F9, VWF, F3
32aprotinin46 129.7F10, VWF, F3, F9
33tranexamic acid46 129.7F3, F9, VWF, F8
34ristocetin468.7F3, VWF, F8, F9
35desmopressin46 62 30 1211.7F3, F9, F8, VWF
36homocysteine46 259.7F3, F8, F9, VWF
37cyclophosphamide46 52 1210.7VWF, F8, F3, F9
38aspirin46 52 30 2511.6F3, F8, VWF, F10
39glutamine468.4F9, VWF, F10, F8
40hirudin468.3F3, F10, VWF, F9, F8
41warfarin46 52 25 1211.3F8, F3, F10, F9, VWF
42citrate468.3VWF, F9, F10, F3, F8
43phosphatidylserine46 30 1210.3F10, F8, F3, VWF, F9
44fibrinogen468.3F10, F9, VWF, F8, F3
45phospholipid468.3F9, VWF, F10, F3, F8
46aspartate468.3F3, VWF, F8, F10, F9
47heparin46 30 25 1211.3F9, F10, VWF, F3, F8
48alanine468.2F3, F10, F8, F9, VWF
49adp46 30 2510.2F10, F9, F3, F8, VWF
50cysteine468.1VWF, F9, F3, F8, F10

GO Terms for genes affiliated with Hemarthrosis

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17Gene Ontology
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Cellular components related to Hemarthrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:0057969.7F9, F10
2intrinsic component of external side of plasma membraneGO:0312339.2F10, F3
3platelet alpha granule lumenGO:0310939.2F8, VWF
4extracellular regionGO:0055768.0F8, VWF, F9, F13B, F10

Biological processes related to Hemarthrosis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1peptidyl-glutamic acid carboxylationGO:0171879.7F10, F9
2platelet degranulationGO:0025769.5VWF, F8
3positive regulation of protein kinase B signalingGO:0518978.9F3, F10
4blood coagulation, extrinsic pathwayGO:0075988.9F9, F10, F3
5cell adhesionGO:0071558.9MSLNL, VWF, F8
6blood coagulation, intrinsic pathwayGO:0075978.9F8, VWF, F9, F10
7blood coagulationGO:0075967.4VWF, F9, F13B, F10, F3, F8

Molecular functions related to Hemarthrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phospholipid bindingGO:0055439.2F3, F10
2serine-type endopeptidase activityGO:0042529.1F8, F10, F9
3protease bindingGO:0020208.8F3, VWF

Products for genes affiliated with Hemarthrosis

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  • Antibodies
  • Proteins
  • Lysates
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Sources for Hemarthrosis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet