MCID: HMR002
MIFTS: 52

Hemarthrosis malady

Bone diseases category
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Summaries for Hemarthrosis

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Wikipedia:65 Hemarthrosis (or haemarthrosis, plural h(a)emarthroses) is a bleeding into joint spaces. more...

MalaCards based summary: Hemarthrosis, also known as haemarthrosis of shoulder joint, is related to glanzmann's thrombasthenia and arthropathy. An important gene associated with Hemarthrosis is F9 (coagulation factor IX), and among its related pathways are PTM- gamma carboxylation, hypusine formation and arylsulfatase activation and Response to elevated platelet cytosolic Ca2+. The compounds recombinate and kogenate have been mentioned in the context of this disorder. Affiliated tissues include bone, skeletal muscle and myeloid, and related mouse phenotype homeostasis/metabolism.

Aliases & Classifications for Hemarthrosis

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Hemarthrosis, Aliases & Descriptions:

Name: Hemarthrosis 8 10 44 62
Haemarthrosis of Shoulder Joint 8 62
Hemarthrosis Involving Pelvic Region and Thigh 8
Haemarthrosis of the Pelvic Region and Thigh 8
Hemarthrosis of the Pelvic Region and Thigh 8
Hemarthrosis Involving Shoulder Region 8
Hemarthrosis Involving Ankle and Foot 8
Hemarthrosis of the Ankle and/or Foot 8
Haemarthrosis of the Shoulder Region 62
Hemarthrosis of the Shoulder Region 8
Haemarthrosis of the Ankle and Foot 8
Hemarthrosis of the Ankle and Foot 8
Hemarthrosis of Ankle and/or Foot 8
Hemarthrosis Involving Upper Arm 8
Haemarthrosis of Shoulder Region 62
Hemarthrosis Involving Lower Leg 8
Hemarthrosis of Shoulder Region 8
Hemarthrosis Involving Forearm 8
Haemarthrosis of the Lower Leg 62
 
Haemarthrosis of the Upper Arm 62
Hemarthrosis of the Lower Leg 8
Hemarthrosis of the Upper Arm 8
Haemarthrosis of the Forearm 62
Hemarthrosis Involving Hand 8
Hemarthrosis of the Forearm 8
Haemarthrosis of Lower Leg 62
Haemarthrosis of Upper Arm 62
Haemarthrosis of Shoulder 62
Haemarthrosis of the Hand 62
Hemarthrosis of Upper Arm 8
Hemarthrosis of Lower Leg 8
Haemarthrosis of Forearm 62
Hemarthrosis of the Hand 8
Hemarthrosis of Shoulder 8
Hemarthrosis of Forearm 8
Haemarthrosis of Hand 62
Hemarthrosis of Hand 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases


External Ids:

Disease Ontology8 DOID:801
ICD9CM27 719.1, 719.10
MeSH34 D006395

Related Diseases for Hemarthrosis

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Diseases related to Hemarthrosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 99)
idRelated DiseaseScoreTop Affiliating Genes
1glanzmann's thrombasthenia30.5VWF
2arthropathy30.4F9, F8
3factor x deficiency30.3F3, F10, F9
4factor v deficiency30.3F8, F3
5factor xi deficiency30.3F8, F3, F9
6amyloidosis30.1F10, F9
7acute myocardial infarction30.1F3, F10, VWF
8hemophilia b29.8F8, F3, F10, F9
9afibrinogenemia29.7VWF, F10, F3, F8
10myocardial infarction29.6F8, F3, F10, F9, VWF
11systemic lupus erythematosus29.6VWF, F10, F3, F8
12hemorrhagic disease29.4VWF, F9, F10, F3, F8
13hemophilia10.5
14cardiac tamponade10.4F8
15thrombophlebitis10.4F8
16angiodysplasia10.4VWF
17carotid artery thrombosis10.4F3
18synovitis10.4
19arthritis10.3
20scurvy10.2
21protein s deficiency10.2F8, F3
22thrombasthenia10.2
23aneurysm10.2
24peripheral vascular disease10.2F3, VWF
25viral hepatitis10.2F8, F10
26sickle cell disease10.2F9, VWF
27coronary thrombosis10.1F3, VWF
28bladder carcinoma10.1F10, F9
29stroke, ischemic10.1F3, VWF
30hypercholesterolemia10.1F8, F10, F9
31osteoarthritis10.1
32pigmented villonodular synovitis10.1
33villonodular synovitis10.1
34lipoma10.1
35purpura10.1
36acquired hemophilia10.1
37pulmonary embolism10.1F3, F10, F9
38factor viii deficiency10.1F9, F3, F8
39hemolytic anemia10.1VWF, F3
40hepatitis10.1F8, F10, F9
41bernard-soulier syndrome10.1VWF, F9, F8
42hyperhomocysteinemia10.1VWF, F9, F8
43factor xii deficiency10.1F3, F13B
44hypothyroidism10.1VWF, F9, F8
45blood platelet disease10.1VWF, F10, F8
46pregnancy loss10.0F10, F3, F8
47liver cirrhosis10.0F9, F10, F3
48sepsis10.0F3, F10, F9
49thrombocytosis10.0F3, F10, VWF
50connective tissue disease10.0F3, VWF

Graphical network of the top 20 diseases related to Hemarthrosis:



Diseases related to hemarthrosis

Symptoms for Hemarthrosis

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Drugs & Therapeutics for Hemarthrosis

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Drug clinical trials:

Search ClinicalTrials for Hemarthrosis

Search NIH Clinical Center for Hemarthrosis

Genetic Tests for Hemarthrosis

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Anatomical Context for Hemarthrosis

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MalaCards organs/tissues related to Hemarthrosis:

32
Bone, Skeletal muscle, Myeloid, Monocytes, B cells

Animal Models for Hemarthrosis or affiliated genes

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MGI Mouse Phenotypes related to Hemarthrosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.9F8, F3, F10, F9, VWF

Publications for Hemarthrosis

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Articles related to Hemarthrosis:

(show top 50)    (show all 205)
idTitleAuthorsYear
1
Occult Intra-articular Knee Injuries in Children With Hemarthrosis. (24753236)
2014
2
Hemarthrosis in hemophilic mice results in alterations in M1-M2 monocyte/macrophage polarization. (24252538)
2013
3
Recurrent hemarthrosis : an unusual cause. (23680622)
2013
4
Antiplasmin, but not amiloride, prevents synovitis and cartilage damage following hemarthrosis in hemophilic mice. (24283895)
2013
5
Knee hemarthrosis after arthroscopic surgery in an athlete with low factor XIII activity. (23031577)
2012
6
Spontaneous recurrent hemarthrosis of the knee joint in the elderly: a report of two cases. (21607723)
2012
7
MRI findings in adolescent patients with acute traumatic knee hemarthrosis. (23147616)
2012
8
Intra-articular nodular fasciitis of the knee: a rare cause of recurrent hemarthrosis. (21431289)
2012
9
A rare case of meniscal hematoma with hemarthrosis of the knee: a case report. (21938355)
2011
10
Glanzmann thrombasthenia detected because of knee hemarthrosis: a case report. (20736850)
2010
11
Hemarthrosis due to a rare cause of hemorrhagic diathesis: Ehlers-Danlos syndrome. (18432503)
2008
12
A case of delayed recurrent hemarthrosis after posterolateral reconstruction of the knee with a staple fixation at the lateral femoral epicondyle. (18365223)
2008
13
Embolization of spontaneous hemarthrosis post total knee replacement. (18185956)
2008
14
In vitro multipotentiality and characterization of human unfractured traumatic hemarthrosis-derived progenitor cells: A potential cell source for tissue repair. (17171634)
2007
15
Recurrent hemarthrosis after knee joint arthroplasty: etiology and treatment. (14973857)
2004
16
Hemarthrosis and scurvy. (12180758)
2002
17
Yersinia enterocolitica O:3 infection of a prosthetic knee joint related to recurrent hemarthrosis. (11928845)
2002
18
Spontaneous hemarthrosis 6 years after total knee arthroplasty. (11172285)
2001
19
Hemarthrosis as initial presentation of scurvy. (11508601)
2001
20
Cytogenetic studies in patients with hemophilic hemarthrosis treated by 198Au, 186Rh, and 90Y radioactive synoviorthesis. (10647112)
2000
21
Recurrent spontaneous hemarthrosis associated with reflex sympathetic dystrophy. (9523789)
1998
22
Hemarthrosis and hip joint pressure in femoral neck fractures. (9728169)
1998
23
Recurrent acute hemarthrosis after anterior cruciate ligament reconstruction. Report of an unusual complication and a review of the literature. (8739716)
1996
24
Cuff tear arthropathy with hemarthrosis. A report on 3 elderly patients. (9065069)
1996
25
Surgical orthopedic correction of hemophilic hemarthrosis at Ramathibodi Hospital. (7886589)
1993
26
Recurrent spontaneous hemarthrosis nine years after a total knee arthroplasty. A presentation with pigmented villonodular synovitis. (8501094)
1993
27
Acute traumatic knee hemarthrosis. (8461076)
1993
28
Recurrent hemarthrosis associated with gout. (1555350)
1992
29
Reduction and osteosynthesis of subcapital fractures of the femoral neck: possible repercussions on post-fracture hemarthrosis of the hip. (1345649)
1992
30
Hemarthrosis in patients with acquired factor VIII inhibitor. (1902518)
1991
31
Hemarthrosis of the ankle secondary to false aneurysm caused by impingement from an osteophyte. A case report. (2745490)
1989
32
Late hemarthrosis from a threaded acetabular component. (3361321)
1988
33
Hemarthrosis after femoral neck fracture fixation. (3188856)
1988
34
The significance of hemarthrosis of the knee in children. (3358674)
1988
35
Spontaneous hemarthrosis associated with an exostosis of the talus. (3572920)
1987
36
Differentiating pyogenic arthritis from spontaneous hemarthrosis in patients with hemophilia. (3953068)
1986
37
Intracapsular pressure and hemarthrosis following femoral neck fracture. (6692612)
1984
38
The presence of siderosomes in synovioblasts (B cells) of chronic spontaneous hemarthrosis. Histologic, electron microscopic, and roentgenographic electron microanalysis studies of three cases. (6548901)
1984
39
Hemarthrosis in an heparinized patient. (856220)
1977
40
Letter: Hemarthrosis secondary to heparin therapy. (962976)
1976
41
On the pathogenesis of hemophilic hemarthrosis]. (808446)
1975
42
Hemarthrosis. (1053879)
1975
43
Management of hemarthrosis. (5440065)
1970
44
Double-blind studies on the use of steroids in the treatment of acute hemarthrosis in patients with hemophilia. (4907066)
1970
45
Chronic myeloid leukemia with hemarthrosis. A case report. (5231484)
1967
46
Experimental hemarthrosis. The response of canine knees to injections of autologous blood. (6018731)
1967
47
Hemarthrosis complicating anticoagulant therapy. Report of three cases. (5952425)
1966
48
Experimental hemarthrosis: the removal of chromium-51- and iron-59-labeled erythrocytes injected into the knee joint of rabbit and man. (14438187)
1960
49
Some observations on experimental hemarthrosis and the pathogenesis of hemophilic arthritis. (14438188)
1959
50
The use of hyaluronidase in the treatment of acute hemophilic hemarthrosis. (13035639)
1953

Variations for Hemarthrosis

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Expression for genes affiliated with Hemarthrosis

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Expression patterns in normal tissues for genes affiliated with Hemarthrosis

Search GEO for disease gene expression data for Hemarthrosis.

Pathways for genes affiliated with Hemarthrosis

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Pathways related to Hemarthrosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7F10, F9
2
Show member pathways
9.5F8, VWF
39.4F8, F13B
4
Show member pathways
7.8F9, F13B, F10, F3, F8
5
Show member pathways
7.3VWF, F9, F13B, F10, F3, F8
6
Show member pathways
Complement Activation, Classical Pathway37
Complement and Coagulation Cascades37
7.3VWF, F9, F13B, F10, F3, F8
7
Show member pathways
7.3F8, F3, F10, F13B, F9, VWF

Compounds for genes affiliated with Hemarthrosis

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Compounds related to Hemarthrosis according to GeneCards/GeneDecks:

(show top 50)    (show all 103)
idCompoundScoreTop Affiliating Genes
1recombinate449.8F8, VWF
2kogenate449.8VWF, F8
3echicetin449.6F9, VWF
4tributylphosphate449.6F8, VWF, F9
5roxifiban449.5F3, F10
6ivig449.4F9, F8, VWF
7efegatran449.4F10, F3
8desirudin449.3F10, F3
9organon449.3F10, F9, F3
10fondaparinux449.3F9, F10, F3
11rituximab44 50 1111.3VWF, F9, F8
12coumarins449.3F9, F3, F10
13ecarin449.2F3, F10
14gamma-carboxyglutamic acid449.2F3, F9, F10
15coumarin44 2 50 2412.2F3, F9, F10
16rfviii449.2F9, VWF, F8, F10
17dextran sulfate449.2F3, F10, F9
18dabigatran50 4410.1F3, F10
19tinzaparin44 1110.1F10, VWF, F3
20acetaminophen44 2 50 24 1113.1F8, F9, F10, VWF
21ppack449.1F10, F3, VWF
22cardiolipin44 1110.1F10, F8, F3
23tirofiban44 1110.1F10, F3, VWF
24abciximab44 1110.1VWF, F10, F3
25hydroxyethyl starch449.1VWF, F8, F3
26clopidogrel44 50 24 1112.1VWF, F3, F10
27kininogen449.0F9, F3, VWF
28guanidine hydrochloride448.9F3, VWF, F10
29kaolin448.9F3, F9, F10, F8
30cacl2448.9F3, F10, F8, F9
31dermatan sulfate448.8F10, F9, VWF, F3
32aprotinin44 119.7F10, VWF, F3, F9
33tranexamic acid44 119.7F3, F9, VWF, F8
34ristocetin448.7F3, VWF, F8, F9
35desmopressin44 61 28 1111.7F3, F9, F8, VWF
36homocysteine44 249.7F3, F8, F9, VWF
37cyclophosphamide44 50 1110.7VWF, F8, F3, F9
38aspirin44 50 28 2411.6F3, F8, VWF, F10
39glutamine448.4F9, VWF, F10, F8
40hirudin448.3F3, F10, VWF, F9, F8
41warfarin44 50 24 1111.3F8, F3, F10, F9, VWF
42citrate448.3VWF, F9, F10, F3, F8
43phosphatidylserine44 28 1110.3F10, F8, F3, VWF, F9
44fibrinogen448.3F10, F9, VWF, F8, F3
45phospholipid448.3F9, VWF, F10, F3, F8
46aspartate448.3F3, VWF, F8, F10, F9
47heparin44 28 24 1111.3F9, F10, VWF, F3, F8
48alanine448.2F3, F10, F8, F9, VWF
49adp44 28 2410.2F10, F9, F3, F8, VWF
50cysteine448.1VWF, F9, F3, F8, F10

GO Terms for genes affiliated with Hemarthrosis

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Cellular components related to Hemarthrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:0057969.7F10, F9
2intrinsic component of external side of plasma membraneGO:0312339.2F3, F10
3platelet alpha granule lumenGO:0310939.2F8, VWF
4extracellular regionGO:0055768.0VWF, F9, F13B, F10, F8

Biological processes related to Hemarthrosis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1peptidyl-glutamic acid carboxylationGO:0171879.7F10, F9
2platelet degranulationGO:0025769.5F8, VWF
3positive regulation of protein kinase B signalingGO:0518978.9F3, F10
4blood coagulation, extrinsic pathwayGO:0075988.9F9, F10, F3
5cell adhesionGO:0071558.9VWF, MSLNL, F8
6blood coagulation, intrinsic pathwayGO:0075978.9F8, F10, F9, VWF
7blood coagulationGO:0075967.4VWF, F9, F13B, F10, F3, F8

Molecular functions related to Hemarthrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phospholipid bindingGO:0055439.2F3, F10
2serine-type endopeptidase activityGO:0042529.1F8, F10, F9
3protease bindingGO:0020208.8F3, VWF

Products for genes affiliated with Hemarthrosis

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Sources for Hemarthrosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet