MCID: HMR002
MIFTS: 50

Hemarthrosis malady

Summaries for Hemarthrosis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Hemarthrosis (or haemarthrosis, plural h(a)emarthroses) is a bleeding into joint spaces. more...

MalaCards: Hemarthrosis, also known as hemarthrosis involving pelvic region and thigh, is related to arthropathy and acute myocardial infarction. An important gene associated with Hemarthrosis is F9 (coagulation factor IX), and among its related pathways are Selected targets of HNF1 and Platelet Aggregation Inhibitor Pathway, Pharmacodynamics. The compounds warfarin and tributylphosphate have been mentioned in the context of this disorder. Affiliated tissues include bone, skeletal muscle and myeloid, and related mouse phenotypes are cardiovascular system and homeostasis/metabolism.

Aliases & Classifications for Hemarthrosis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH
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Aliases & Descriptions:

hemarthrosis 8 10 44 60
hemarthrosis involving pelvic region and thigh 8
haemarthrosis of the pelvic region and thigh 8
hemarthrosis of the pelvic region and thigh 8
hemarthrosis involving shoulder region 8
hemarthrosis of the ankle and/or foot 8
hemarthrosis involving ankle and foot 8
hemarthrosis of the shoulder region 8
haemarthrosis of the ankle and foot 8
hemarthrosis of the ankle and foot 8
hemarthrosis of ankle and/or foot 8
hemarthrosis involving lower leg 8
hemarthrosis involving upper arm 8
hemarthrosis of shoulder region 8
haemarthrosis of shoulder joint 8
hemarthrosis involving forearm 8
hemarthrosis of the lower leg 8
hemarthrosis of the upper arm 8
hemarthrosis of the forearm 8
hemarthrosis involving hand 8
hemarthrosis of lower leg 8
hemarthrosis of upper arm 8
hemarthrosis of the hand 8
hemarthrosis of shoulder 8
hemarthrosis of forearm 8
hemarthrosis of hand 8


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Disease Ontology8 DOID:801
ICD9CM27 719.1, 719.10
MeSH34 D006395

Related Diseases for Hemarthrosis

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17GeneCards, 18GeneDecks
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Diseases related to Hemarthrosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 112)
idRelated DiseaseScoreTop Affiliating Genes
1arthropathy30.0F8, F9
2acute myocardial infarction30.0VWF, F3, F10
3factor x deficiency30.0F2, F3, F10, F9
4factor xi deficiency30.0F9, F8, F3, F2
5myocardial infarction30.0F9, F8, F10, F3, VWF
6hemorrhagic disease29.8F9
7hemangioma29.8F8
8ischemia29.8F10
9amyloidosis29.8F9, F10
10lupus erythematosus29.8F3, F2
11leukemia29.8F9, F8, F10
12factor v deficiency29.8F8, F3, F2
13glanzmann's thrombasthenia29.8F9, F8, F10, F3, VWF
14hemophilia b29.8F9, F8, F10, F3, F2
15afibrinogenemia29.8F8, F10, F3, VWF, F2
16systemic lupus erythematosus29.8F8, F10, F3, VWF, F2
17hemophilia10.5
18synovitis10.3
19arthritis10.2
20scurvy10.2
21pigmented villonodular synovitis10.0
22osteoarthritis10.0
23villonodular synovitis10.0
24lipoma10.0
25purpura10.0
26nephrotic syndrome10.0F9
27thrombophlebitis10.0F8
28acquired immunodeficiency syndrome10.0F8
29hellp syndrome10.0VWF
30hemolytic-uremic syndrome10.0VWF
31intermittent claudication10.0VWF
32warfarin sensitivity10.0F9
33angiodysplasia10.0VWF
34cardiac tamponade10.0F8
35endocarditis10.0F10
36uremia10.0VWF
37carotid artery thrombosis10.0F3
38sickle cell disease10.0VWF, F9
39cystic fibrosis10.0F8, F9
40coronary heart disease10.0F10, VWF
41varicose veins10.0F2
42liver cirrhosis10.0F2
43dysfibrinogenemia10.0F2
44atherosclerosis10.0VWF, F3
45peritonitis10.0F2
46peripheral vascular disease10.0F3, VWF
47hypercholesterolemia10.0F10, F8, F9
48factor xii deficiency10.0F3, F13B
49coronary thrombosis10.0F3, VWF
50protein c deficiency10.0F9, F2

Graphical network of the top 20 diseases related to Hemarthrosis:



Diseases related to hemarthrosis

Clinical Features for Hemarthrosis

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Drugs & Therapeutics for Hemarthrosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Hemarthrosis

Drug clinical trials:

Search ClinicalTrials for Hemarthrosis

Search NIH Clinical Center for Hemarthrosis

Search CenterWatch for Hemarthrosis

Genetic Tests for Hemarthrosis

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Anatomical Context for Hemarthrosis

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32MalaCards
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MalaCards organs/tissues related to Hemarthrosis:

32
Bone, Skeletal muscle, Myeloid, Monocytes, B cells

Animal Models for Hemarthrosis or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Hemarthrosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.3F2, F3, F10, F9
2MP:00053767.1F2, F9, F8, F10, F3, VWF

Publications for Hemarthrosis

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50PubMed
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Articles related to Hemarthrosis:

(show top 50)    (show all 206)
idTitleAuthorsYear
1
A case of selective arterial embolization for recurrent hemarthrosis after total knee arthroplasty. (22237971)
2013
2
Cartilage and bone markers and inflammatory cytokines are increased in synovial fluid in the acute phase of knee injury (hemarthrosis)--a cross-sectional analysis. (22874525)
2012
3
A rare case of meniscal hematoma with hemarthrosis of the knee: a case report. (21938355)
2011
4
Recurrent hemarthrosis after total knee arthroplasty. (20076944)
2010
5
Spontaneous recurrent hemarthrosis of the knee joint in elderly patients with osteoarthritis: an infrequent presentation of synovial lipoma arborescens. (20526580)
2010
6
Angiographic findings and therapeutic embolization of late hemarthrosis after total joint arthroplasty. (18773205)
2009
7
Hemarthrosis due to a rare cause of hemorrhagic diathesis: Ehlers-Danlos syndrome. (18432503)
2008
8
A case of delayed recurrent hemarthrosis after posterolateral reconstruction of the knee with a staple fixation at the lateral femoral epicondyle. (18365223)
2008
9
Embolization of spontaneous hemarthrosis post total knee replacement. (18185956)
2008
10
Spontaneous recurrent hemarthrosis of the knee in the elderly: arthroscopic treatment and etiology. (18760210)
2008
11
Hemarthrosis revealing congenital factor XI deficiency. (18378181)
2008
12
Therapeutic embolization for the treatment of recurrent hemarthrosis after total knee arthroplasty due to an arteriovenous fistula. (18078896)
2007
13
A prospective magnetic resonance imaging study of the incidence of posterolateral and multiple ligament injuries in acute knee injuries presenting with a hemarthrosis. (18063179)
2007
14
Delayed recurrent hemarthrosis after staple fixation of tibial avulsion fracture of the posterior cruciate ligament: a case report. (16534654)
2006
15
Shoulder hemarthrosis due to a bleeding pseudoaneurysm. (15940564)
2005
16
Recurrent hemarthrosis after knee joint arthroplasty: etiology and treatment. (14973857)
2004
17
Hemarthrosis of the knees following streptokinase therapy for acute myocardial infarction. (12875278)
2003
18
Acute traumatic hemarthrosis of the knee. Is routine arthroscopic examination necessary? A study of 320 consecutive patients. (12558087)
2002
19
Hemarthrosis: an unusual complication of type 1 neurofibromatosis. (11592378)
2001
20
Therapeutic embolization of the genicular arteries for recurrent hemarthrosis after total knee arthroplasty. (11607913)
2001
21
Recurrent spontaneous hemarthrosis associated with reflex sympathetic dystrophy. (9523789)
1998
22
Hemarthrosis and tourniquet use. (9728713)
1998
23
Spontaneous recurrent hemarthrosis of the knee joint: endovascular treatment of a ruptured aneurysm with platinum microcoils. A case report. (9111408)
1997
24
Cartilage damage as a result of hemarthrosis in a human in vitro model. (9228136)
1997
25
The diagnostic validity of magnetic resonance imaging in acute knee injuries with hemarthrosis. A single-blinded evaluation in 69 patients using high-field MRI before arthroscopy. (8739577)
1996
26
Recurrent hemarthrosis following a total knee arthroplasty. (8776057)
1995
27
Proteoglycan degradation in hemarthrosis. Intraarticular, autologous blood injection in rat knees. (7863774)
1995
28
The effect of experimental hemarthrosis on joint stiffness and synovial histology in a rabbit model. (8194245)
1994
29
Acute hemarthrosis of the knee. (1607844)
1992
30
Hemarthrosis in patients with acquired factor VIII inhibitor. (1902518)
1991
31
Hemarthrosis and oral anticoagulants. (1865684)
1991
32
99mTc-DPD uptake in juvenile hemarthrosis. Scintimetry and autoradiography of the knee in dogs. (2710706)
1989
33
A case of acetabular fracture with hip tamponade. Relief from aspiration of hemarthrosis. (2603667)
1989
34
Experimental hemarthrosis in dogs: progressive synovitis monitored with technetium-99m pyrophosphate joint imaging. (2842240)
1988
35
Sudden open bite resulting from hemarthrosis: report of a case. (3164061)
1988
36
Hemarthrosis and idiopathic thrombocytopenic purpura. (3599011)
1987
37
A long-term study of hemophilic arthropathy of the knee joint on a program of Factor VIII replacement given at time of each hemarthrosis. (3917602)
1985
38
Avulsion of the popliteus tendon. A rare cause of chondral fracture and hemarthrosis. (4073352)
1985
39
Intracapsular pressure and hemarthrosis following femoral neck fracture. (6692612)
1984
40
The presence of siderosomes in synovioblasts (B cells) of chronic spontaneous hemarthrosis. Histologic, electron microscopic, and roentgenographic electron microanalysis studies of three cases. (6548901)
1984
41
Hemarthrosis secondary to suspected warfarin toxicosis in a dog. (6863130)
1983
42
Hemarthrosis from heparin therapy. (7382051)
1980
43
Hemarthrosis of the temporomandibular joint in a patient with hemophilia B: report of case. (286767)
1979
44
The management of deep soft tissue bleeding and hemarthrosis in hemophilia. (5011042)
1972
45
Double-blind studies on the use of steroids in the treatment of acute hemarthrosis in patients with hemophilia. (4907066)
1970
46
Hemarthrosis. (4921532)
1970
47
Hemarthrosis complicating anticoagulant therapy. Report of three cases. (5952425)
1966
48
Some observations on experimental hemarthrosis and the pathogenesis of hemophilic arthritis. (14438188)
1959
49
The use of hyaluronidase in the treatment of acute hemophilic hemarthrosis. (13035639)
1953
50
The treatment of acute hemophilic hemarthrosis; a report on the use of hyaluronidase. (13002609)
1952

Genetic Variations for Hemarthrosis

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Expression for genes affiliated with Hemarthrosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hemarthrosis

Search GEO for disease gene expression data for Hemarthrosis.

Pathways for genes affiliated with Hemarthrosis

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Sources:
12EMD Millipore, 49PharmGKB, 53Reactome, 51QIAGEN, 37NCBI BioSystems Database, 52R&D Systems, 29KEGG
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Pathways related to Hemarthrosis according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5F13B, F8
29.4F2, VWF
3
Hide members
9.4VWF, F2
49.1F2, F10, F9
5
Hide members
8.8F9, F8, F10, F13B
6
Hide members
8.6F2, VWF, F3
7
Hide members
8.3F9, F10, F3, F2
8
Hide members
8.1F10, F13B, F3, F2
9
Hide members
7.4F9, F8, F10, F13B, F3, F2
10
Hide members
6.9F9, F8, F10, F13B, F3, VWF
11
Hide members
6.9F2, F9, F8, F10, F13B, F3

Compounds for genes affiliated with Hemarthrosis

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 2BitterDB, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Hemarthrosis according to GeneCards/GeneDecks:

(show top 50)    (show all 129)
idCompoundScoreTop Affiliating Genes
1warfarin44 49 11 2413.1VWF, F9
2tributylphosphate449.6F8, VWF, F9
3Gamma-Carboxy-Glutamic Acid119.5F2, F9, F10
4Coagulation Factor IX119.4F8, F10, F2
5rfviii449.3F9, F8, VWF, F10
6Antihemophilic Factor119.2VWF, F2, F10
7tinzaparin44 1110.1F10, VWF, F3
8ecarin449.0F10, F3, F2
9spectrozyme449.0F2, F3, F10
10danaparoid449.0F10, F3, F2
11ximelagatran44 119.9F10, F3, F2
12rivaroxaban44 119.9F2, F3, F10
13cacl2448.9F8, F9, F3, F10
14heparinoids448.9F2, F3, F10
15aprotinin44 119.9F9, F3, VWF, F10
16acenocoumarol44 49 1110.9F9, F3, F2
17bivalirudin44 119.8F10, F2, F3
18argatroban44 119.8F3, F10, F2
19phenprocoumon44 49 1110.8F3, F2, F9
20organon448.7F9, F10, F3, F2
21fondaparinux448.7F3, F2, F10, F9
22coumarins448.7F3, F2, F10, F9
23gamma-carboxyglutamic acid448.7F10, F3, F2, F9
24acetaminophen44 2 49 11 2412.7F9, F10, VWF, F2, F8
25coumarin44 2 49 2411.7F2, F9, F10, F3
26protamine sulfate448.7F10, F3, F2
27ppack448.6F2, VWF, F3, F10
28tirofiban44 119.6F10, F3, VWF, F2
29cardiolipin44 119.6F2, F3, F8, F10
30hydroxyethyl starch448.6F8, F3, VWF, F2
31abciximab44 119.6F2, VWF, F3, F10
32clopidogrel49 44 11 2411.6F10, VWF, F2, F3
33kininogen448.5F9, F3, VWF, F2
34epsilon aminocaproic acid448.4F9, F2, F3
35kaolin448.4F2, F9, F8, F10, F3
36dermatan sulfate448.3F9, VWF, F3, F10, F2
37tranexamic acid44 119.3F9, F8, F3, F2, VWF
38ristocetin448.3VWF, F2, F3, F8, F9
39desmopressin44 59 28 1111.3VWF, F9, F3, F2, F8
40homocysteine44 249.2VWF, F8, F3, F9, F2
41simvastatin44 49 59 28 11 2413.2F3, VWF, F10, F2
42aspirin44 49 28 2411.1F10, F8, F2, F3, VWF
43hirudin447.9F3, F10, F8, F2, VWF, F9
44citrate447.9F9, F2, F3, VWF, F8, F10
45phosphatidylserine44 28 119.9F3, F10, F8, F9, F2, VWF
46fibrinogen447.8F9, F10, F2, VWF, F8, F3
47phospholipid447.8F10, F2, F9, F8, VWF, F3
48aspartate447.8F3, F8, F10, F9, VWF, F2
49heparin44 28 11 2410.8F8, F10, F3, VWF, F2, F9
50alanine447.3F2, F9, VWF, F8, F10, F3

GO Terms for genes affiliated with Hemarthrosis

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16Gene Ontology
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Cellular components related to Hemarthrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.6VWF, F8
2intrinsic to external side of plasma membraneGO:0312339.3F3, F10
3Golgi lumenGO:0057969.0F9, F10, F2
4endoplasmic reticulum lumenGO:0057888.8F2, F10, F9
5extracellular regionGO:0055767.8F2, VWF, F13B, F10, F8, F9

Biological processes related to Hemarthrosis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1acute-phase responseGO:0069539.4F2, F8
2peptidyl-glutamic acid carboxylationGO:0171879.1F2, F10, F9
3post-translational protein modificationGO:0436879.0F9, F10, F2
4blood coagulation, extrinsic pathwayGO:0075989.0F9, F10, F3
5platelet activationGO:0301688.7F2, VWF, F8
6blood coagulation, intrinsic pathwayGO:0075978.4F2, VWF, F10, F8, F9
7blood coagulationGO:0075967.0F9, F8, F10, F13B, F3, VWF

Molecular functions related to Hemarthrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase activityGO:0042529.1F2, F10, F9

Products for genes affiliated with Hemarthrosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hemarthrosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet