MCID: HMR002
MIFTS: 50

Hemarthrosis malady

Summaries for Hemarthrosis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Hemarthrosis (or haemarthrosis, plural h(a)emarthroses) is a bleeding into joint spaces. more...

MalaCards: Hemarthrosis, also known as hemarthrosis involving pelvic region and thigh, is related to arthropathy and acute myocardial infarction. An important gene associated with Hemarthrosis is F9 (coagulation factor IX), and among its related pathways are Selected targets of HNF1 and Platelet Aggregation Inhibitor Pathway, Pharmacodynamics. The compounds warfarin and tributylphosphate have been mentioned in the context of this disorder. Affiliated tissues include bone, skeletal muscle and myeloid, and related mouse phenotypes are cardiovascular system and homeostasis/metabolism.

Aliases & Classifications for Hemarthrosis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH
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Aliases & Descriptions:

hemarthrosis 8 10 44 60
hemarthrosis involving pelvic region and thigh 8
haemarthrosis of the pelvic region and thigh 8
hemarthrosis of the pelvic region and thigh 8
hemarthrosis involving shoulder region 8
hemarthrosis of the ankle and/or foot 8
hemarthrosis involving ankle and foot 8
hemarthrosis of the shoulder region 8
haemarthrosis of the ankle and foot 8
hemarthrosis of the ankle and foot 8
hemarthrosis of ankle and/or foot 8
hemarthrosis involving lower leg 8
hemarthrosis involving upper arm 8
hemarthrosis of shoulder region 8
haemarthrosis of shoulder joint 8
hemarthrosis involving forearm 8
hemarthrosis of the lower leg 8
hemarthrosis of the upper arm 8
hemarthrosis of the forearm 8
hemarthrosis involving hand 8
hemarthrosis of lower leg 8
hemarthrosis of upper arm 8
hemarthrosis of the hand 8
hemarthrosis of shoulder 8
hemarthrosis of forearm 8
hemarthrosis of hand 8


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Disease Ontology8 DOID:801
ICD9CM27 719.1, 719.10
MeSH34 D006395

Related Diseases for Hemarthrosis

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17GeneCards, 18GeneDecks
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Diseases related to Hemarthrosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 112)
idRelated DiseaseScoreTop Affiliating Genes
1arthropathy30.0F8, F9
2acute myocardial infarction30.0VWF, F3, F10
3factor x deficiency30.0F2, F3, F10, F9
4factor xi deficiency30.0F9, F8, F3, F2
5myocardial infarction30.0F9, F8, F10, F3, VWF
6hemorrhagic disease29.8F9
7hemangioma29.8F8
8ischemia29.8F10
9amyloidosis29.8F9, F10
10lupus erythematosus29.8F3, F2
11leukemia29.8F9, F8, F10
12factor v deficiency29.8F8, F3, F2
13glanzmann's thrombasthenia29.8F9, F8, F10, F3, VWF
14hemophilia b29.8F9, F8, F10, F3, F2
15afibrinogenemia29.8F8, F10, F3, VWF, F2
16systemic lupus erythematosus29.8F8, F10, F3, VWF, F2
17hemophilia10.5
18synovitis10.3
19arthritis10.2
20scurvy10.2
21pigmented villonodular synovitis10.0
22osteoarthritis10.0
23villonodular synovitis10.0
24lipoma10.0
25purpura10.0
26nephrotic syndrome10.0F9
27thrombophlebitis10.0F8
28acquired immunodeficiency syndrome10.0F8
29hellp syndrome10.0VWF
30hemolytic-uremic syndrome10.0VWF
31intermittent claudication10.0VWF
32warfarin sensitivity10.0F9
33angiodysplasia10.0VWF
34cardiac tamponade10.0F8
35endocarditis10.0F10
36uremia10.0VWF
37carotid artery thrombosis10.0F3
38sickle cell disease10.0VWF, F9
39cystic fibrosis10.0F8, F9
40coronary heart disease10.0F10, VWF
41varicose veins10.0F2
42liver cirrhosis10.0F2
43dysfibrinogenemia10.0F2
44atherosclerosis10.0VWF, F3
45peritonitis10.0F2
46peripheral vascular disease10.0F3, VWF
47hypercholesterolemia10.0F10, F8, F9
48factor xii deficiency10.0F3, F13B
49coronary thrombosis10.0F3, VWF
50protein c deficiency10.0F9, F2

Graphical network of the top 20 diseases related to Hemarthrosis:



Diseases related to hemarthrosis

Clinical Features for Hemarthrosis

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Drugs & Therapeutics for Hemarthrosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Hemarthrosis

Drug clinical trials:

Search ClinicalTrials for Hemarthrosis

Search NIH Clinical Center for Hemarthrosis

Search CenterWatch for Hemarthrosis

Genetic Tests for Hemarthrosis

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Anatomical Context for Hemarthrosis

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32MalaCards
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MalaCards organs/tissues related to Hemarthrosis:

32
Bone, Skeletal muscle, Myeloid, Monocytes, B cells

Animal Models for Hemarthrosis or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Hemarthrosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.3F9, F10, F3, F2
2MP:00053767.1F9, F8, F10, F3, VWF, F2

Publications for Hemarthrosis

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50PubMed
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Articles related to Hemarthrosis:

(show top 50)    (show all 206)
idTitleAuthorsYear
1
Recurrent hemarthrosis : an unusual cause. (23680622)
2013
2
Antiplasmin, but not amiloride, prevents synovitis and cartilage damage following hemarthrosis in hemophilic mice. (24283895)
2013
3
A case of bilateral hemarthrosis due to pseudoaneurysms in a patient on anticoagulation therapy. (23669803)
2013
4
Knee hemarthrosis after arthroscopic surgery in an athlete with low factor XIII activity. (23031577)
2012
5
Spontaneous recurrent hemarthrosis of the knee joint in the elderly: a report of two cases. (21607723)
2012
6
MRI findings in adolescent patients with acute traumatic knee hemarthrosis. (23147616)
2012
7
Recurrent hemarthrosis in a boy with synovial hemangioma: a case report. (21088622)
2011
8
Recurrent hemarthrosis after unicompartmental knee arthroplasty. (21902161)
2011
9
Recurrent hemarthrosis in a hemophilic patient after revision total knee arthroplasty. (20954656)
2010
10
Acute traumatic hemarthrosis of the adult's knee--a diagnostic options in arthroscopic era. Literature review. (19133435)
2008
11
Isolation and characterization of connective tissue progenitor cells derived from human fracture-induced hemarthrosis in vitro. (17763429)
2008
12
Hemarthrosis as acute presentation of acquired hemophilia in a patient with systemic lupus erythematosus: successful treatment and long-lasting remission. (18827958)
2008
13
Hemarthrosis associated with failure of a mobile meniscal-bearing total knee arthroplasty. A case report. (14668519)
2003
14
Therapeutic embolization for late hemarthrosis after total knee arthroplasty. A case report. (12954841)
2003
15
Hemarthrosis in acquired hemophilia. Two case-reports. (14667566)
2003
16
Spontaneous hemarthrosis of the knee associated with clopidogrel and aspirin treatment. (12624808)
2003
17
Hemarthrosis and scurvy. (12180758)
2002
18
The role of arthroscopic synovectomy in the management of hemarthrosis in hemophilia patients: financial perspectives. (12209438)
2002
19
Traumatic Hemarthrosis of the Knee Secondary to Hemophilia A in a Collegiate Soccer Player: A Case Report. (12937588)
2002
20
Hemarthrosis after trauma to the pediatric knee joint: what is the value of magnetic resonance imaging in the diagnostic algorithm? (11371817)
2001
21
Cytogenetic studies in patients with hemophilic hemarthrosis treated by 198Au, 186Rh, and 90Y radioactive synoviorthesis. (10647112)
2000
22
Hemarthrosis of the ankle revealing an aneurysm of the anterior tibial artery. (10380266)
1999
23
Decreased Quick percentage, acquired factor X deficiency, hemarthrosis and ecchymosis: amyloidosis]. (10517125)
1999
24
Anatomic and radioanatomic study of the lateral genicular arteries: application to prevention of postoperative hemarthrosis after arthroscopic lateral retinacular release. (10370993)
1999
25
Hemarthrosis as a major complication after arthroscopic subcutaneous lateral retinacular release: a prospective study. (9586738)
1998
26
Hemarthrosis of the knee and bone contusion. (9255057)
1997
27
Open synovectomy for the prevention of recurrent hemarthrosis of the ankle in patients with hemophilia. A report of five cases with magnetic resonance imaging documentation. (9090765)
1997
28
Spontaneous recurrent hemarthrosis of the knee with lesion of the lateral meniscus and arthrosis of the lateral compartment. (9269116)
1997
29
Hemarthrosis and synovitis associated with hemophilia: clinical use of P-32 chromic phosphate synoviorthesis for treatment. (8259416)
1994
30
Atraumatic spontaneous hemarthrosis associated with Lyme arthritis. A case report. (8242943)
1993
31
Ultrastructural changes in synovium and cartilage in experimental hemarthrosis in dogs. (2344263)
1990
32
Late hemarthrosis from a threaded acetabular component. (3361321)
1988
33
Hemarthrosis after femoral neck fracture fixation. (3188856)
1988
34
Persistent hemarthrosis of the shoulder joint with a rotator-cuff tear in the elderly. (3408314)
1988
35
Obstructive sleep apnea caused by hemarthrosis-induced micrognathia. (3817070)
1987
36
Differentiating pyogenic arthritis from spontaneous hemarthrosis in patients with hemophilia. (3953068)
1986
37
Hemarthrosis in undisplaced cervical fractures. Tamponade may cause reversible femoral head ischemia. (3788490)
1986
38
Vitamin K deficiency presenting with hemarthrosis. (6490891)
1984
39
Acute arthroscopy in posttraumatic hemarthrosis of the knee joint. (6888769)
1983
40
Arthroscopy in acute traumatic hemarthrosis of the knee. Incidence of anterior cruciate tears and other injuries. (7391091)
1980
41
Hemarthrosis associated with Glanzmann's thrombasthenia. (518722)
1979
42
Hemarthrosis in psoriatic arthritis. (861064)
1977
43
Hemarthrosis. (1053879)
1975
44
Hemarthrosis as the presenting manifestation of myeloproliferative disease. (1119948)
1975
45
Hemarthrosis as the presenting manifestation of myeloproliferative disease. (4433355)
1974
46
Treatment of hemarthrosis in hemophilia. (5448344)
1970
47
Hemarthrosis and sickle cell trait. (5495397)
1970
48
Ultrastructure of synovial membrane in human hemarthrosis. (4169060)
1967
49
Experimental hemarthrosis: the removal of chromium-51- and iron-59-labeled erythrocytes injected into the knee joint of rabbit and man. (14438187)
1960
50
The effect of closed drainage of the knee on postoperative hemarthrosis: an experimental study. (14808447)
1951

Genetic Variations for Hemarthrosis

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Expression for genes affiliated with Hemarthrosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hemarthrosis

Search GEO for disease gene expression data for Hemarthrosis.

Pathways for genes affiliated with Hemarthrosis

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Sources:
12EMD Millipore, 49PharmGKB, 53Reactome, 51QIAGEN, 37NCBI BioSystems Database, 52R&D Systems, 29KEGG
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Pathways related to Hemarthrosis according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5F13B, F8
29.4F2, VWF
3
Hide members
9.4VWF, F2
49.1F2, F10, F9
5
Hide members
8.8F9, F8, F10, F13B
6
Hide members
8.6F2, VWF, F3
7
Hide members
8.3F9, F10, F3, F2
8
Hide members
8.1F10, F13B, F3, F2
9
Hide members
7.4F9, F8, F10, F13B, F3, F2
10
Hide members
6.9F9, F8, F10, F13B, F3, VWF
11
Hide members
6.9F2, F9, F8, F10, F13B, F3

Compounds for genes affiliated with Hemarthrosis

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 2BitterDB, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Hemarthrosis according to GeneCards/GeneDecks:

(show top 50)    (show all 129)
idCompoundScoreTop Affiliating Genes
1warfarin44 49 11 2413.1VWF, F9
2tributylphosphate449.6F8, VWF, F9
3Gamma-Carboxy-Glutamic Acid119.5F2, F9, F10
4Coagulation Factor IX119.4F8, F10, F2
5rfviii449.3F9, F8, VWF, F10
6Antihemophilic Factor119.2VWF, F2, F10
7tinzaparin44 1110.1F10, VWF, F3
8ecarin449.0F10, F3, F2
9spectrozyme449.0F2, F3, F10
10danaparoid449.0F10, F3, F2
11ximelagatran44 119.9F10, F3, F2
12rivaroxaban44 119.9F2, F3, F10
13cacl2448.9F8, F9, F3, F10
14heparinoids448.9F2, F3, F10
15aprotinin44 119.9F9, F3, VWF, F10
16acenocoumarol44 49 1110.9F9, F3, F2
17bivalirudin44 119.8F10, F2, F3
18argatroban44 119.8F3, F10, F2
19phenprocoumon44 49 1110.8F3, F2, F9
20organon448.7F9, F10, F3, F2
21fondaparinux448.7F3, F2, F10, F9
22coumarins448.7F3, F2, F10, F9
23gamma-carboxyglutamic acid448.7F10, F3, F2, F9
24acetaminophen44 2 49 11 2412.7F9, F10, VWF, F2, F8
25coumarin44 2 49 2411.7F2, F9, F10, F3
26protamine sulfate448.7F10, F3, F2
27ppack448.6F2, VWF, F3, F10
28tirofiban44 119.6F10, F3, VWF, F2
29cardiolipin44 119.6F2, F3, F8, F10
30hydroxyethyl starch448.6F8, F3, VWF, F2
31abciximab44 119.6F2, VWF, F3, F10
32clopidogrel49 44 11 2411.6F10, VWF, F2, F3
33kininogen448.5F9, F3, VWF, F2
34epsilon aminocaproic acid448.4F9, F2, F3
35kaolin448.4F2, F9, F8, F10, F3
36dermatan sulfate448.3F9, VWF, F3, F10, F2
37tranexamic acid44 119.3F9, F8, F3, F2, VWF
38ristocetin448.3VWF, F2, F3, F8, F9
39desmopressin44 59 28 1111.3VWF, F9, F3, F2, F8
40homocysteine44 249.2VWF, F8, F3, F9, F2
41simvastatin44 49 59 28 11 2413.2F3, VWF, F10, F2
42aspirin44 49 28 2411.1F10, F8, F2, F3, VWF
43hirudin447.9F3, F10, F8, F2, VWF, F9
44citrate447.9F9, F2, F3, VWF, F8, F10
45phosphatidylserine44 28 119.9F3, F10, F8, F9, F2, VWF
46fibrinogen447.8F9, F10, F2, VWF, F8, F3
47phospholipid447.8F10, F2, F9, F8, VWF, F3
48aspartate447.8F3, F8, F10, F9, VWF, F2
49heparin44 28 11 2410.8F8, F10, F3, VWF, F2, F9
50alanine447.3F2, F9, VWF, F8, F10, F3

GO Terms for genes affiliated with Hemarthrosis

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Sources:
16Gene Ontology
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Cellular components related to Hemarthrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.6VWF, F8
2intrinsic to external side of plasma membraneGO:0312339.3F3, F10
3Golgi lumenGO:0057969.0F9, F10, F2
4endoplasmic reticulum lumenGO:0057888.8F2, F10, F9
5extracellular regionGO:0055767.8F2, VWF, F13B, F10, F8, F9

Biological processes related to Hemarthrosis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1acute-phase responseGO:0069539.4F2, F8
2peptidyl-glutamic acid carboxylationGO:0171879.1F2, F10, F9
3post-translational protein modificationGO:0436879.0F9, F10, F2
4blood coagulation, extrinsic pathwayGO:0075989.0F9, F10, F3
5platelet activationGO:0301688.7F2, VWF, F8
6blood coagulation, intrinsic pathwayGO:0075978.4F2, VWF, F10, F8, F9
7blood coagulationGO:0075967.0F9, F8, F10, F13B, F3, VWF

Molecular functions related to Hemarthrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase activityGO:0042529.1F2, F10, F9

Products for genes affiliated with Hemarthrosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hemarthrosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet