MCID: HMT002
MIFTS: 60

Hematologic Cancer malady

Immune diseases, Blood diseases, Cancer diseases categories

Summaries for Hematologic Cancer

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Disease Ontology:10 An immune system cancer located in the hematological system that is characterized by uncontrolled cellular proliferation in blood, bone marrow and lymph nodes.

MalaCards based summary: Hematologic Cancer, also known as hematologic malignancies, is related to paraneoplastic syndromes and aplastic anemia. An important gene associated with Hematologic Cancer is PTHLH (parathyroid hormone-like hormone), and among its related pathways are Apoptosis and survival Caspase cascade and FOXM1 transcription factor network. The compounds gossypol and teniposide have been mentioned in the context of this disorder. Affiliated tissues include the hematological system, bone and bone marrow, and related mouse phenotypes are pigmentation and adipose tissue.

Aliases & Classifications for Hematologic Cancer

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Hematologic Cancer, Aliases & Descriptions:

Name: Hematologic Cancer 32 10 45
Hematologic Malignancies 45 62
Hematologic Neoplasm 10 24
Hematopoietic and Lymphoid System Tumor 10
Malignant Haematopoietic Neoplasm 62
Malignant Hematopoietic Neoplasm 10
Haematologic Malignancy 62
Hematopoietic Neoplasms 62
 
Hematopoietic Neoplasm 10
Hematologic Malignancy 10
Hematologic Neoplasms 62
Hematopoietic Tumors 10
Hematological Tumors 10
Hematopoietic Cancer 10
Blood Cancer 10


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Immune diseases, Blood diseases


External Ids:

Disease Ontology10 DOID:2531
NCIt40 C27134
MeSH35 D019337

Related Diseases for Hematologic Cancer

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Diseases related to Hematologic Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 231)
idRelated DiseaseScoreTop Affiliating Genes
1paraneoplastic syndromes30.4PTHLH, CSF3
2aplastic anemia30.3BRCA1, BRCA2
3hodgkin lymphoma30.3CSF3, BRCA1, BRCA2
4chronic lymphocytic leukemia30.3RB1, BRCA2
5myeloma30.2PTHLH, BCL2L11, CSF3, RB1
6burkitt lymphoma30.1RB1, CSF3, BCL2L11, BRCA2, PTHLH
7breast cancer30.0BRCA1, BRCA2
8retinoblastoma29.9BRCA2, BRCA1, RB1
9prostate cancer29.9PTHLH, BRCA2, BRCA1, BCL2L11, RB1
10leukemia29.8BRCA2, BRCA1, BCL2L11, CSF3, RB1
11hematopoietic stem cell transplantation10.6
12neutropenia10.5
13bacteremia10.4
14b-cell lymphomas10.4
15zygomycosis10.4
16hyperuricemia10.3
17fusariosis10.3
18endotheliitis10.3
19myelodysplastic syndrome10.3
20mantle cell lymphoma10.3
21pulmonary alveolar proteinosis10.3
22candidiasis10.3
23multiple myeloma10.2
24diffuse large b-cell lymphoma10.2
25hepatitis10.2
26lymphoblastic lymphoma10.2
27systemic mastocytosis10.2
28strongyloidiasis10.2
29disseminated intravascular coagulation10.2
30eosinophilia10.2
31mediastinitis10.2
32pneumonia10.2
33rhabdomyosarcoma10.2
34sarcoma10.2
35thyroiditis10.2
36acute graft versus host disease10.2
37mastocytosis10.2
38central nervous system hematologic cancer10.2
39refractory hematologic cancer10.2
40hemoglobin c disease10.2
41systemic lupus erythematosus10.1
42mismatch repair cancer syndrome10.1
43leukemia, acute myeloid10.1
44acute biphenotypic leukemia10.1
45acute erythroid leukemia10.1
46adult acute lymphocytic leukemia10.1
47adult t-cell leukemia10.1
48follicular lymphoma10.1
49granuloma annulare10.1
50lymphoma, large-cell, immunoblastic10.1

Graphical network of the top 20 diseases related to Hematologic Cancer:



Diseases related to hematologic cancer

Symptoms for Hematologic Cancer

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Drugs & Therapeutics for Hematologic Cancer

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Drug clinical trials:

Search ClinicalTrials for Hematologic Cancer

Search NIH Clinical Center for Hematologic Cancer

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Hematologic Cancer cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Hematologic Cancer:
ALD-151, umbilical cord blood cells for hematologic and immunodefeciency diseases
Allocord, cord blood-derived hematopoietic progenitor cells for hematopoietic reconstitution
Co-infusion of umbilical cord blood and haploidentical CD34+ cells for hematological diseases
Ducord, umbilical cord blood-derived hematopoietic progenitor cells for hematopoietic reconstitution
Expanded cord blood hematopoietic stem cells for hematologic malignancies
Hemacord
Hematopoietic stem cells for treatment of hematologic malignancies
StemEx
Umbilical cord blood-derived hematopoietic progenitor cells for hematopoietic reconstitution
Umbilical cord blood-derived hematopoietic progenitor cells for hematopoietic reconstitution
Embryonic/Adult Cultured Cells Related to Hematologic Cancer:
Umbilical cord blood ALDH+ cells (ALD-151), PMID: 10430905
Umbilical cord blood-derived hematopoietic progenitor cells (Allocord), PMID: 11953027
Peripheral blood-derived hematopoietic stem cells
Umbilical cord blood-derived hematopoietic progenitor cells (Ducord), PMIDs: 22698485, 21810098, 23711284, 21277377
Mesenchymal Precursor Cells (STRO-3 selected), PMID: 21396596
Expanded umbilical cord blood-derived hematopoietic stem cells, PMID: 21396596
Umbilical cord blood-derived hematopoietic progenitor cells (HEMACORD, PMID: 9828244
Bone marrow-derived hematopoietic stem cells
Umbilical cord blood stem/progenitor cells (Stemex), PMID: 18209724
Umbilical cord blood stem/progenitor cells (Stemex), PMID: 18209724
Umbilical cord blood-derived hematopoietic stem cells (family), PMID: 20676147
Umbilical cord blood-derived hematopoietic stem cells (family)

Genetic Tests for Hematologic Cancer

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Genetic tests related to Hematologic Cancer:

id Genetic test Affiliating Genes
1 Hematologic Neoplasm24

Anatomical Context for Hematologic Cancer

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MalaCards organs/tissues related to Hematologic Cancer:

33
Bone, Bone marrow, Lymph node, Testes, Heart, Breast, Myeloid

FMA organs/tissues related to Hematologic Cancer:

16
The hematological system

Animal Models for Hematologic Cancer or affiliated genes

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Publications for Hematologic Cancer

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Articles related to Hematologic Cancer:

(show all 34)
idTitleAuthorsYear
1
Hospitalization risk according to geriatric assessment and laboratory parameters in elderly hematologic cancer patients. (25684525)
2015
2
Survivorship Care Plans and Treatment Summaries a8"in Adult Patients With Hematologic Cancer: a8"An Integrative Literature Review. (25901380)
2015
3
The microfluidic multitrap nanophysiometer for hematologic cancer cell characterization reveals temporal sensitivity of the calcein-AM efflux assay. (24873950)
2014
4
Design of a cost-effectiveness analysis alongside a randomized trial of transplantation using umbilical cord blood versus HLA-haploidentical related bone marrow in advanced hematologic cancer. (24645687)
2014
5
Combination of vaccine-strain measles and mumps virus synergistically kills a wide range of human hematological cancer cells: Special focus on acute myeloid leukemia. (25193462)
2014
6
The falling incidence of hematologic cancer after heart transplantation. (25100534)
2014
7
Confirmation of the reported association of clonal chromosomal mosaicism with an increased risk of incident hematologic cancer. (23533652)
2013
8
Internet-based program for coping with cancer: a randomized controlled trial with hematologic cancer patients. (22565413)
2013
9
Xist RNA is a potent suppressor of hematologic cancer in mice. (23415223)
2013
10
Evaluation of MycAssaya8c Aspergillus for diagnosis of invasive pulmonary aspergillosis in patients without hematological cancer. (23620764)
2013
11
Thymidylate synthase polymorphisms and hematological cancer risk: a meta-analysis. (22166040)
2012
12
Family history of non-hematologic cancers among Waldenstrom macroglobulinemia patients: a preliminary study. (22099500)
2012
13
p53 codon 72 polymorphism and hematological cancer risk: an update meta-analysis. (23029260)
2012
14
Improving access to information and support for patients with less common cancers: hematologic cancer patients' views about Web-based approaches. (22189354)
2011
15
Physical activity and hematologic cancer prevention. (21113763)
2011
16
Mesial temporal sclerosis as a complication of hematologic cancer. (19434437)
2009
17
Managed care considerations: hematologic cancer as a chronic disease. (19119536)
2008
18
Phase 3 trials suggest ways to improve current hematologic cancer therapies. (18252877)
2008
19
Femoral resurfacing in young patients with hematologic cancer and osteonecrosis. (18679763)
2008
20
Searching for evidence of disease and malignant cell contamination in ovarian tissue stored from hematologic cancer patients. (18344563)
2008
21
Posaconazole prophylaxis in hematologic cancer. (17526090)
2007
22
Posaconazole prophylaxis in hematologic cancer. (17526089)
2007
23
The BRCA1/2 pathway prevents hematologic cancers in addition to breast and ovarian cancers. (17683622)
2007
24
Posaconazole prophylaxis in hematologic cancer. (17522407)
2007
25
Posaconazole prophylaxis in hematologic cancer. (17526091)
2007
26
Serum Aspergillus galactomannan antigen values strongly correlate with outcome of invasive aspergillosis: a study of 56 patients with hematologic cancer. (17607669)
2007
27
Low mannose-binding lectin concentration is associated with severe infection in patients with hematological cancer who are undergoing chemotherapy. (17516403)
2007
28
Patient-rated emotional and physical functioning among hematologic cancer patients during hospitalization for stem-cell transplantation. (15580279)
2005
29
In vitro chemosensitivity testing of hematological cancer patients: detection of ornithine decarboxylase. (12528799)
2003
30
Psychiatric morbidity and impact on hospital length of stay among hematologic cancer patients receiving stem-cell transplantation. (11919251)
2002
31
In vitro chemosensitivity testing of hematological cancers: immunohistochemical detection of ornithine decarboxylase. (10587289)
1999
32
Phase I trial of a 90-minute infusion of the fusion toxin DAB486IL-2 in hematological cancers. (8358720)
1993
33
Autologous bone marrow transplantation for hematologic cancer. (2236163)
1990
34
Alzheimer's disease and senile dementia: genetic relationships to Down's syndrome and hematologic cancer. (154163)
1979

Variations for Hematologic Cancer

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Expression for genes affiliated with Hematologic Cancer

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Search GEO for disease gene expression data for Hematologic Cancer.

Pathways for genes affiliated with Hematologic Cancer

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Pathways related to Hematologic Cancer according to GeneCards/GeneDecks:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
FAS pathway and Stress induction of HSP regulation38
Apoptosis and survival FAS signaling cascades60
Caspase cascade in apoptosis38
9.5RB1, BCL2L11
29.4BRCA2, RB1
3
Show member pathways
9.4RB1, BRCA2
49.2RB1, BRCA1
59.2BRCA1, RB1
6
Show member pathways
9.2RB1, BRCA1
7
Show member pathways
DNA damage response38
9.2RB1, BRCA1
8
Show member pathways
Prostate Cancer38
Integrated Cancer pathway38
Steroid Biosynthesis38
9.2BRCA1, RB1
9
Show member pathways
9.0BRCA1, BRCA2
10
Show member pathways
9.0BRCA1, BRCA2
119.0BRCA1, BRCA2
129.0BRCA1, BRCA2
13
Show member pathways
9.0BRCA2, BRCA1
14
Show member pathways
9.0BRCA1, BRCA2
15
Show member pathways
9.0BRCA1, BRCA2
168.6CSF3, BCL2L11, BRCA1
17
Show member pathways
Signaling Pathways in Glioblastoma38
8.6RB1, BRCA1, BRCA2
18
Show member pathways
8.6RB1, BRCA1, BRCA2
198.6RB1, BRCA1, BRCA2
20
Show member pathways
8.6BRCA2, BRCA1, RB1
21
Show member pathways
8.6BRCA2, BRCA1, RB1
22
Show member pathways
8.2BRCA1, BCL2L11, CSF3, RB1

Compounds for genes affiliated with Hematologic Cancer

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Compounds related to Hematologic Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 73)
idCompoundScoreTop Affiliating Genes
1gossypol459.8RB1, BCL2L11
2teniposide45 1310.8RB1, CSF3
3vinorelbine45 51 1311.3CSF3, BRCA1
48-oxoguanine459.3BRCA2, BRCA1
5aphidicolin459.3RB1, BRCA1
6daidzein459.3BRCA2, BRCA1
7matrigel459.2RB1, BRCA2, PTHLH
8lycopene45 2610.2BRCA1, BRCA2
9agar459.1PTHLH, BRCA1, RB1
10actinomycin d459.1PTHLH, BCL2L11, RB1
11carboplatin45 51 1311.1RB1, CSF3, BRCA1
12platinum45 5110.0CSF3, BRCA1
13indole-3-carbinol459.0BRCA1, BRCA2
145fluorouracil459.0BRCA1, CSF3, RB1
15adpribose459.0BRCA2, BRCA1, RB1
16p003459.0RB1, BRCA1, BRCA2
17p002459.0BRCA2, BRCA1, RB1
18resveratrol45 61 26 1312.0BRCA2, BRCA1, RB1
19camptothecin45 61 1310.9BRCA2, BRCA1, RB1
20hydroxyurea45 51 1310.9CSF3, BRCA1, BRCA2
21dexamethasone45 51 30 1311.9PTHLH, BCL2L11, CSF3, RB1
22polyacrylamide458.9BRCA2, BRCA1, RB1
23docetaxel45 51 61 1311.9BRCA2, BRCA1, CSF3
24tamoxifen45 51 30 1311.8PTHLH, BRCA2, BRCA1
25doxorubicin45 51 1310.8BRCA1, CSF3, RB1
26cyclophosphamide45 51 1310.7PTHLH, BRCA1, CSF3, RB1
27vegf458.6RB1, CSF3, BRCA1, PTHLH
28estradiol45 26 1310.6PTHLH, BRCA2, BRCA1, RB1
29paraffin458.6PTHLH, BRCA2, BRCA1, RB1
30progesterone45 30 61 26 1312.6RB1, BRCA1, BRCA2, PTHLH
31bleomycin45 139.5CSF3, BRCA1, BRCA2, PTHLH
32oxygen45 269.5PTHLH, BRCA1, BCL2L11, RB1
33testosterone45 61 26 1311.5RB1, BRCA1, BRCA2, PTHLH
34steroid458.5RB1, BRCA1, BRCA2, PTHLH
35mitomycin c458.5BRCA2, BRCA1, CSF3, RB1
36adriamycin458.5RB1, CSF3, BRCA1, BRCA2
37methotrexate51 45 1310.5RB1, CSF3, BRCA1, BRCA2
38h2o2458.4RB1, BCL2L11, BRCA1, BRCA2
39oligonucleotide458.4BRCA2, BRCA1, BCL2L11, RB1
40genistein45 30 61 3 26 1313.3RB1, BRCA1, BRCA2
41tyrosine458.1PTHLH, BRCA1, BCL2L11, CSF3, RB1
42vincristine45 51 1310.1PTHLH, BRCA2, BRCA1, CSF3, RB1
43thymidine45 269.1RB1, CSF3, BRCA1, BRCA2, PTHLH
44cisplatin45 51 61 1311.1PTHLH, BRCA2, BRCA1, CSF3, RB1
45phosphatidylinositol458.1PTHLH, BRCA2, BRCA1, BCL2L11, RB1
46estrogen458.1PTHLH, BRCA2, BRCA1, BCL2L11, RB1
47retinoic acid45 269.1RB1, CSF3, BRCA1, BRCA2, PTHLH
48cycloheximide458.0PTHLH, BRCA2, BRCA1, BCL2L11, CSF3
49etoposide45 51 61 1311.0BRCA2, BRCA1, BCL2L11, CSF3, RB1
50paclitaxel45 51 139.6RB1, CSF3, BCL2L11, BRCA1, BRCA2, PTHLH

GO Terms for genes affiliated with Hematologic Cancer

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Biological processes related to Hematologic Cancer according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of sequence-specific DNA binding transcription factor activityGO:00434339.7RB1, PTHLH
2androgen receptor signaling pathwayGO:00305219.3RB1, BRCA1
3intrinsic apoptotic signaling pathway in response to DNA damageGO:00086309.2BCL2L11, BRCA1
4DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00069789.2BRCA1, BRCA2
5double-strand break repair via homologous recombinationGO:00007248.9BRCA1, BRCA2
6double-strand break repairGO:00063028.7BRCA1, BRCA2
7positive regulation of transcription from RNA polymerase II promoterGO:00459448.7RB1, CSF3, BRCA1
8positive regulation of transcription, DNA-templatedGO:00458938.6BRCA2, BRCA1, RB1

Molecular functions related to Hematologic Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1androgen receptor bindingGO:00506819.2RB1, BRCA1

Products for genes affiliated with Hematologic Cancer

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Hematologic Cancer

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet