MCID: HMT002
MIFTS: 52

Hematologic Cancer malady

Immune diseases, Blood diseases, Cancer diseases categories

Aliases & Classifications for Hematologic Cancer

About this section

Aliases & Descriptions for Hematologic Cancer:

Name: Hematologic Cancer 30 8 44
Hematologic Neoplasm 8 22
Malignant Tumor of Lymphoid Hemopoietic and Related Tissue 61
Hematopoietic and Lymphoid System Tumor 8
Malignant Hematopoietic Neoplasm 8
Hematologic Malignancies 44
Hematopoietic Neoplasms 61
 
Hematologic Malignancy 8
Hematopoietic Neoplasm 8
Hematologic Neoplasms 61
Hematopoietic Tumors 8
Hematological Tumors 8
Hematopoietic Cancer 8
Blood Cancer 8


Classifications:



External Ids:

Disease Ontology8 DOID:2531
NCIt39 C27134
MeSH33 D019337

Summaries for Hematologic Cancer

About this section
Disease Ontology:8 An immune system cancer located in the hematological system that is characterized by uncontrolled cellular proliferation in blood, bone marrow and lymph nodes.

MalaCards based summary: Hematologic Cancer, also known as hematologic neoplasm, is related to paraneoplastic syndromes and aplastic anemia. An important gene associated with Hematologic Cancer is PTHLH (parathyroid hormone-like hormone), and among its related pathways are Apoptosis and survival Caspase cascade and FOXM1 transcription factor network. The compounds gossypol and teniposide have been mentioned in the context of this disorder. Affiliated tissues include the hematological system, bone and bone marrow, and related mouse phenotypes are pigmentation and adipose tissue.

Related Diseases for Hematologic Cancer

About this section

Diseases related to Hematologic Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 230)
idRelated DiseaseScoreTop Affiliating Genes
1paraneoplastic syndromes30.6PTHLH, CSF3
2aplastic anemia30.4BRCA1, BRCA2
3hodgkin lymphoma30.0CSF3, BRCA1, BRCA2
4chronic lymphocytic leukemia30.0RB1, BRCA2
5myeloma29.9PTHLH, BCL2L11, CSF3, RB1
6breast cancer29.8BRCA1, BRCA2
7retinoblastoma29.6BRCA2, BRCA1, RB1
8burkitt lymphoma29.3RB1, CSF3, BCL2L11, BRCA2, PTHLH
9prostate cancer29.1PTHLH, BRCA2, BRCA1, BCL2L11, RB1
10leukemia29.0BRCA2, BRCA1, BCL2L11, CSF3, RB1
11hematopoietic stem cell transplantation10.6
12neutropenia10.5
13bacteremia10.4
14b-cell lymphomas10.4
15zygomycosis10.4
16lung cancer10.4CSF3
17hyperuricemia10.3
18fusariosis10.3
19endotheliitis10.3
20myelodysplastic syndrome10.3
21mantle cell lymphoma10.3
22pulmonary alveolar proteinosis10.3
23candidiasis10.3
24central nervous system hematologic cancer10.3
25refractory hematologic cancer10.3
26hereditary breast ovarian cancer10.3BRCA2
27multiple myeloma10.2
28diffuse large b-cell lymphoma10.2
29hepatitis10.2
30lymphoblastic lymphoma10.2
31systemic mastocytosis10.2
32strongyloidiasis10.2
33disseminated intravascular coagulation10.2
34eosinophilia10.2
35mediastinitis10.2
36pneumonia10.2
37rhabdomyosarcoma10.2
38sarcoma10.2
39thyroiditis10.2
40acute graft versus host disease10.2
41mastocytosis10.2
42hemoglobin c disease10.2
43bone cancer10.1RB1, PTHLH
44systemic lupus erythematosus10.1
45mismatch repair cancer syndrome10.1
46leukemia, acute myeloid10.1
47acute biphenotypic leukemia10.1
48acute erythroid leukemia10.1
49adult acute lymphocytic leukemia10.1
50adult t-cell leukemia10.1

Graphical network of the top 20 diseases related to Hematologic Cancer:



Diseases related to hematologic cancer

Symptoms for Hematologic Cancer

About this section

Drugs & Therapeutics for Hematologic Cancer

About this section

Drug clinical trials:

Search ClinicalTrials for Hematologic Cancer

Search NIH Clinical Center for Hematologic Cancer

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Hematologic Cancer cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Hematologic Cancer:
ALD-151, umbilical cord blood cells for hematologic and immunodefeciency diseases
Allocord, cord blood-derived hematopoietic progenitor cells for hematopoietic reconstitution
Co-infusion of umbilical cord blood and haploidentical CD34+ cells for hematological diseases
Ducord, umbilical cord blood-derived hematopoietic progenitor cells for hematopoietic reconstitution
Expanded cord blood hematopoietic stem cells for hematologic malignancies
Hemacord
Hematopoietic stem cells for treatment of hematologic malignancies
StemEx
Umbilical cord blood-derived hematopoietic progenitor cells for hematopoietic reconstitution
Umbilical cord blood-derived hematopoietic progenitor cells for hematopoietic reconstitution
Embryonic/Adult Cultured Cells Related to Hematologic Cancer:
Umbilical cord blood ALDH+ cells (ALD-151), PMID: 10430905
Umbilical cord blood-derived hematopoietic progenitor cells (Allocord), PMID: 11953027
Peripheral blood-derived hematopoietic stem cells
Umbilical cord blood-derived hematopoietic progenitor cells (Ducord), PMIDs: 22698485, 21810098, 23711284, 21277377
Mesenchymal Precursor Cells (STRO-3 selected), PMID: 21396596
Expanded umbilical cord blood-derived hematopoietic stem cells, PMID: 21396596
Umbilical cord blood-derived hematopoietic progenitor cells (HEMACORD, PMID: 9828244
Bone marrow-derived hematopoietic stem cells
Umbilical cord blood stem/progenitor cells (Stemex), PMID: 18209724
Umbilical cord blood stem/progenitor cells (Stemex), PMID: 18209724
Umbilical cord blood-derived hematopoietic stem cells (family), PMID: 20676147
Umbilical cord blood-derived hematopoietic stem cells (family)

Genetic Tests for Hematologic Cancer

About this section

Genetic tests related to Hematologic Cancer:

id Genetic test Affiliating Genes
1 Hematologic Neoplasm22

Anatomical Context for Hematologic Cancer

About this section

MalaCards organs/tissues related to Hematologic Cancer:

31
Bone, Bone marrow, Lymph node, Testes, Heart, Breast, Myeloid

FMA organs/tissues related to Hematologic Cancer:

14
The hematological system

Animal Models for Hematologic Cancer or affiliated genes

About this section

Publications for Hematologic Cancer

About this section

Articles related to Hematologic Cancer:

(show all 34)
idTitleAuthorsYear
1
Hospitalization risk according to geriatric assessment and laboratory parameters in elderly hematologic cancer patients. (25684525)
2015
2
Survivorship Care Plans and Treatment Summaries a8"in Adult Patients With Hematologic Cancer: a8"An Integrative Literature Review. (25901380)
2015
3
The microfluidic multitrap nanophysiometer for hematologic cancer cell characterization reveals temporal sensitivity of the calcein-AM efflux assay. (24873950)
2014
4
Design of a cost-effectiveness analysis alongside a randomized trial of transplantation using umbilical cord blood versus HLA-haploidentical related bone marrow in advanced hematologic cancer. (24645687)
2014
5
Combination of vaccine-strain measles and mumps virus synergistically kills a wide range of human hematological cancer cells: Special focus on acute myeloid leukemia. (25193462)
2014
6
The falling incidence of hematologic cancer after heart transplantation. (25100534)
2014
7
Confirmation of the reported association of clonal chromosomal mosaicism with an increased risk of incident hematologic cancer. (23533652)
2013
8
Internet-based program for coping with cancer: a randomized controlled trial with hematologic cancer patients. (22565413)
2013
9
Xist RNA is a potent suppressor of hematologic cancer in mice. (23415223)
2013
10
Evaluation of MycAssaya8c Aspergillus for diagnosis of invasive pulmonary aspergillosis in patients without hematological cancer. (23620764)
2013
11
Thymidylate synthase polymorphisms and hematological cancer risk: a meta-analysis. (22166040)
2012
12
Family history of non-hematologic cancers among Waldenstrom macroglobulinemia patients: a preliminary study. (22099500)
2012
13
p53 codon 72 polymorphism and hematological cancer risk: an update meta-analysis. (23029260)
2012
14
Improving access to information and support for patients with less common cancers: hematologic cancer patients' views about Web-based approaches. (22189354)
2011
15
Physical activity and hematologic cancer prevention. (21113763)
2011
16
Mesial temporal sclerosis as a complication of hematologic cancer. (19434437)
2009
17
Managed care considerations: hematologic cancer as a chronic disease. (19119536)
2008
18
Phase 3 trials suggest ways to improve current hematologic cancer therapies. (18252877)
2008
19
Femoral resurfacing in young patients with hematologic cancer and osteonecrosis. (18679763)
2008
20
Searching for evidence of disease and malignant cell contamination in ovarian tissue stored from hematologic cancer patients. (18344563)
2008
21
Posaconazole prophylaxis in hematologic cancer. (17526090)
2007
22
Posaconazole prophylaxis in hematologic cancer. (17526089)
2007
23
The BRCA1/2 pathway prevents hematologic cancers in addition to breast and ovarian cancers. (17683622)
2007
24
Posaconazole prophylaxis in hematologic cancer. (17522407)
2007
25
Posaconazole prophylaxis in hematologic cancer. (17526091)
2007
26
Serum Aspergillus galactomannan antigen values strongly correlate with outcome of invasive aspergillosis: a study of 56 patients with hematologic cancer. (17607669)
2007
27
Low mannose-binding lectin concentration is associated with severe infection in patients with hematological cancer who are undergoing chemotherapy. (17516403)
2007
28
Patient-rated emotional and physical functioning among hematologic cancer patients during hospitalization for stem-cell transplantation. (15580279)
2005
29
In vitro chemosensitivity testing of hematological cancer patients: detection of ornithine decarboxylase. (12528799)
2003
30
Psychiatric morbidity and impact on hospital length of stay among hematologic cancer patients receiving stem-cell transplantation. (11919251)
2002
31
In vitro chemosensitivity testing of hematological cancers: immunohistochemical detection of ornithine decarboxylase. (10587289)
1999
32
Phase I trial of a 90-minute infusion of the fusion toxin DAB486IL-2 in hematological cancers. (8358720)
1993
33
Autologous bone marrow transplantation for hematologic cancer. (2236163)
1990
34
Alzheimer's disease and senile dementia: genetic relationships to Down's syndrome and hematologic cancer. (154163)
1979

Variations for Hematologic Cancer

About this section

Expression for genes affiliated with Hematologic Cancer

About this section
Search GEO for disease gene expression data for Hematologic Cancer.

Pathways for genes affiliated with Hematologic Cancer

About this section

Pathways related to Hematologic Cancer according to GeneCards Suite gene sharing:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
FAS pathway and Stress induction of HSP regulation36
Apoptosis and survival FAS signaling cascades59
Caspase cascade in apoptosis36
9.5RB1, BCL2L11
29.4BRCA2, RB1
3
Show member pathways
9.4RB1, BRCA2
49.2RB1, BRCA1
59.2BRCA1, RB1
6
Show member pathways
9.2RB1, BRCA1
7
Show member pathways
DNA damage response36
9.2RB1, BRCA1
8
Show member pathways
Prostate Cancer36
Integrated Cancer pathway36
Steroid Biosynthesis36
9.2BRCA1, RB1
9
Show member pathways
9.0BRCA1, BRCA2
109.0BRCA1, BRCA2
119.0BRCA1, BRCA2
12
Show member pathways
9.0BRCA2, BRCA1
13
Show member pathways
9.0BRCA1, BRCA2
14
Show member pathways
9.0BRCA1, BRCA2
158.6CSF3, BCL2L11, BRCA1
16
Show member pathways
Signaling Pathways in Glioblastoma36
8.6RB1, BRCA1, BRCA2
17
Show member pathways
8.6RB1, BRCA1, BRCA2
188.6RB1, BRCA1, BRCA2
19
Show member pathways
8.6BRCA2, BRCA1, RB1
20
Show member pathways
8.6BRCA2, BRCA1, RB1
21
Show member pathways
8.2BRCA1, BCL2L11, CSF3, RB1

Compounds for genes affiliated with Hematologic Cancer

About this section

Compounds related to Hematologic Cancer according to GeneCards Suite gene sharing:

(show top 50)    (show all 73)
idCompoundScoreTop Affiliating Genes
1gossypol449.8BCL2L11, RB1
2teniposide44 1110.8RB1, CSF3
3vinorelbine44 50 1111.3CSF3, BRCA1
48-oxoguanine449.3BRCA1, BRCA2
5aphidicolin449.3RB1, BRCA1
6daidzein449.3BRCA1, BRCA2
7matrigel449.2BRCA2, RB1, PTHLH
8lycopene44 2410.2BRCA1, BRCA2
9agar449.1RB1, PTHLH, BRCA1
10actinomycin d449.1RB1, PTHLH, BCL2L11
11carboplatin44 50 1111.1RB1, CSF3, BRCA1
12platinum44 5010.0CSF3, BRCA1
13indole-3-carbinol449.0BRCA2, BRCA1
145fluorouracil449.0RB1, CSF3, BRCA1
15adpribose449.0RB1, BRCA2, BRCA1
16p003449.0BRCA1, BRCA2, RB1
17p002449.0RB1, BRCA1, BRCA2
18resveratrol44 60 24 1112.0BRCA1, RB1, BRCA2
19camptothecin44 60 1110.9RB1, BRCA1, BRCA2
20hydroxyurea44 50 1110.9BRCA2, BRCA1, CSF3
21dexamethasone44 50 28 1111.9RB1, PTHLH, BCL2L11, CSF3
22polyacrylamide448.9BRCA2, BRCA1, RB1
23docetaxel44 50 60 1111.9BRCA1, CSF3, BRCA2
24tamoxifen44 50 28 1111.8PTHLH, BRCA2, BRCA1
25doxorubicin44 50 1110.8BRCA1, CSF3, RB1
26cyclophosphamide44 50 1110.7BRCA1, CSF3, PTHLH, RB1
27vegf448.6RB1, PTHLH, BRCA1, CSF3
28estradiol44 24 1110.6PTHLH, BRCA2, BRCA1, RB1
29paraffin448.6BRCA2, BRCA1, PTHLH, RB1
30progesterone44 28 60 24 1112.6BRCA1, PTHLH, BRCA2, RB1
31bleomycin44 119.5BRCA2, BRCA1, CSF3, PTHLH
32oxygen44 249.5BCL2L11, RB1, BRCA1, PTHLH
33testosterone44 60 24 1111.5BRCA1, BRCA2, PTHLH, RB1
34steroid448.5PTHLH, BRCA2, BRCA1, RB1
35mitomycin c448.5CSF3, BRCA2, RB1, BRCA1
36adriamycin448.5BRCA2, BRCA1, CSF3, RB1
37methotrexate50 44 1110.5BRCA1, RB1, CSF3, BRCA2
38h2o2448.4BRCA1, BRCA2, BCL2L11, RB1
39oligonucleotide448.4BRCA2, RB1, BRCA1, BCL2L11
40genistein44 28 60 1 24 1113.3BRCA2, BRCA1, RB1
41tyrosine448.1CSF3, BCL2L11, BRCA1, PTHLH, RB1
42vincristine44 50 1110.1PTHLH, RB1, BRCA2, BRCA1, CSF3
43thymidine44 249.1RB1, BRCA1, BRCA2, PTHLH, CSF3
44cisplatin44 50 60 1111.1BRCA2, CSF3, PTHLH, BRCA1, RB1
45phosphatidylinositol448.1BRCA1, PTHLH, BRCA2, BCL2L11, RB1
46estrogen448.1PTHLH, RB1, BRCA1, BRCA2, BCL2L11
47retinoic acid44 249.1BRCA1, RB1, CSF3, BRCA2, PTHLH
48cycloheximide448.0BRCA2, PTHLH, BCL2L11, CSF3, BRCA1
49etoposide44 50 60 1111.0BRCA2, CSF3, RB1, BCL2L11, BRCA1
50paclitaxel44 50 119.6BRCA1, RB1, CSF3, BCL2L11, BRCA2, PTHLH

GO Terms for genes affiliated with Hematologic Cancer

About this section

Biological processes related to Hematologic Cancer according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of sequence-specific DNA binding transcription factor activityGO:00434339.7RB1, PTHLH
2androgen receptor signaling pathwayGO:00305219.3RB1, BRCA1
3intrinsic apoptotic signaling pathway in response to DNA damageGO:00086309.2BCL2L11, BRCA1
4DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00069789.2BRCA1, BRCA2
5double-strand break repair via homologous recombinationGO:00007248.9BRCA1, BRCA2
6double-strand break repairGO:00063028.7BRCA1, BRCA2
7positive regulation of transcription from RNA polymerase II promoterGO:00459448.7RB1, CSF3, BRCA1
8positive regulation of transcription, DNA-templatedGO:00458938.6BRCA2, BRCA1, RB1

Molecular functions related to Hematologic Cancer according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1androgen receptor bindingGO:00506819.2RB1, BRCA1

Sources for Hematologic Cancer

About this section
2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet