MCID: HMT002
MIFTS: 56

Hematologic Cancer malady

Summaries for Hematologic Cancer

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Disease Ontology:8 An immune system cancer located in the hematological system that is characterized by uncontrolled cellular proliferation in blood, bone marrow and lymph nodes.

MalaCards: Hematologic Cancer, also known as hematologic neoplasm, is related to acute leukemia and graft versus host disease. An important gene associated with Hematologic Cancer is PTHLH (parathyroid hormone-like hormone), and among its related pathways are Inhibition of Ribosome Biogenesis by p14(ARF) and IL2 signaling events mediated by PI3K. The compounds estrogen and dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include the hematological system, and related mouse phenotypes are embryogenesis and limbs/digits/tail.

Wikipedia:64 Hematological malignancies (British spelling \"Haematological\" malignancies) are the types of cancer... more...

Aliases & Classifications for Hematologic Cancer

Sources:
8Disease Ontology, 45Novoseek, 31LifeMap Discovery™, 22GTR, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt
See all sources

Aliases & Descriptions:

hematologic cancer 8 45 31
hematologic neoplasm 8 22
hematopoietic and lymphoid system tumor 8
malignant hematopoietic neoplasm 8
hematologic malignancies 45
hematopoietic neoplasms 61
hematologic malignancy 8
hematopoietic neoplasm 8
hematologic neoplasms 61
hematological tumors 8
hematopoietic tumors 8
hematopoietic cancer 8
blood cancer 8


External Ids:

Disease Ontology8 DOID:2531
MeSH35 D019337
NCIt40 C27134

Related Diseases for Hematologic Cancer

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Hematologic Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 306)
idRelated DiseaseScoreTop Affiliating Genes
1acute leukemia30.6CSF3, IL2
2graft versus host disease30.5CSF3, IL2RA, IL2RB, IL2
3paraneoplastic syndromes30.3CSF3, PTHLH
4aplastic anemia30.3BRCA2, BRCA1
5acute graft versus host disease30.2CSF3, IL2RA, IL2RB, IL2
6t-cell leukemia30.2TYMS, IL2RA, IL2RB, IL2, FCER2, PTHLH
7hypercalcemia30.1PTHLH
8myelodysplastic syndromes30.1CSF3
9aspergillosis30.1MBL2
10adult acute lymphocytic leukemia30.1TYMS
11systemic lupus erythematosus30.1MBL2, IL2RA, IL2RB, IL2, FCER2
12thymoma29.9IL2
13alzheimer's disease29.9IL2RB
14hemophagocytic lymphohistiocytosis29.9IL2RA
15acquired immunodeficiency syndrome29.9IL2
16adult t-cell leukemia29.9PTHLH, IL2RA
17anaplastic large cell lymphoma29.9IL2RB, IL2RA
18wilms tumor29.9ODC1, BRCA2
19urticaria29.9FCER2
20mycosis fungoides29.9IL2RA, IL2RB, IL2
21diphtheria29.9IL2RA, IL2RB, IL2
22acute lymphocytic leukemia29.9CSF3, RB1, TYMS, PTHLH
23leukopenia29.9CSF3, TYMS, IL2
24non-hodgkin lymphoma29.9CSF3, IL2RA, IL2RB, IL2, FCER2
25burkitt's lymphoma29.8TP53, ODC1, BRCA2, CSF3, RB1, TYMS
26hematopoietic stem cell transplantation10.5
27bacteremia10.4
28zygomycosis10.3
29hyperuricemia10.3
30fusariosis10.3
31acute myeloid leukemia10.3
32mantle cell lymphoma10.3
33n syndrome10.3
34strongyloidiasis10.2
35hepatitis c10.2
36pulmonary alveolar proteinosis10.2
37hepatitis d10.2
38lymphoblastic lymphoma10.2
39sepsis10.2
40central nervous system hematologic cancer10.2
41hemoglobin e disease10.2
42megakaryocytic leukemia10.1
43neurofibromatosis10.1
44hemoglobin d disease10.1
45acute t cell leukemia10.1
46pancytopenia10.1
47pyomyositis10.1
48diffuse large b-cell lymphoma10.1
49splenic marginal zone lymphoma10.1
50granuloma annulare10.1

Graphical network of the top 20 diseases related to Hematologic Cancer:



Diseases related to hematologic cancer

Clinical Features for Hematologic Cancer

Drugs & Therapeutics for Hematologic Cancer

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Hematologic Cancer

Drug clinical trials:

Search ClinicalTrials for Hematologic Cancer

Search NIH Clinical Center for Hematologic Cancer

Search CenterWatch for Hematologic Cancer

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Hematologic Cancer cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Hematologic Cancer:
ALD-151, umbilical cord blood cells for hematologic and immunodefeciency diseases
Allocord, cord blood-derived hematopoietic progenitor cells for hematopoietic reconstitution
Co-infusion of umbilical cord blood and haploidentical CD34+ cells for hematological diseases
Ducord, umbilical cord blood-derived hematopoietic progenitor cells for hematopoietic reconstitution
Expanded cord blood hematopoietic stem cells for hematologic malignancies
Hemacord
Hematopoietic stem cells for treatment of hematologic malignancies
StemEx
Umbilical cord blood-derived hematopoietic progenitor cells for hematopoietic reconstitution
Umbilical cord blood-derived hematopoietic progenitor cells for hematopoietic reconstitution
Embryonic/Adult Cultured Cells Related to Hematologic Cancer:
Umbilical cord blood ALDH+ cells (ALD-151), PMID: 10430905
Umbilical cord blood-derived hematopoietic progenitor cells (Allocord), PMID: 11953027
Peripheral blood-derived hematopoietic stem cells
Umbilical cord blood-derived hematopoietic progenitor cells (Ducord), PMIDs: 22698485, 21810098, 23711284, 21277377
Mesenchymal Precursor Cells (STRO-3 selected), PMID: 21396596
Expanded umbilical cord blood-derived hematopoietic stem cells, PMID: 21396596
Umbilical cord blood-derived hematopoietic progenitor cells (HEMACORD, PMID: 9828244
Bone marrow-derived hematopoietic stem cells
Umbilical cord blood stem/progenitor cells (Stemex), PMID: 18209724
Umbilical cord blood-derived hematopoietic stem cells (family), PMID: 20676147
Umbilical cord blood-derived hematopoietic stem cells (family)

Genetic Tests for Hematologic Cancer

Sources:
22GTR
See all sources

Genetic tests related to Hematologic Cancer:

id Genetic test Affiliating Genes
1 Hematologic Neoplasm22

Anatomical Context for Hematologic Cancer

Sources:
14FMA
See all sources

FMA organs/tissues related to Hematologic Cancer:

14
The hematological system

Animal Models for Hematologic Cancer or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Hematologic Cancer

Sources:
51PubMed
See all sources

Articles related to Hematologic Cancer:

(show top 50)    (show all 54)
idTitleAuthorsYear
1
Confirmation of the reported association of clonal chromosomal mosaicism with an increased risk of incident hematologic cancer. (23533652)
2013
2
Internet-based program for coping with cancer: a randomized controlled trial with hematologic cancer patients. (22565413)
2013
3
Xist RNA is a potent suppressor of hematologic cancer in mice. (23415223)
2013
4
Refining the UGT1A haplotype associated with irinotecan-induced hematological toxicity in metastatic colorectal cancer patients treated with 5-fluorouracil/irinotecan-based regimens. (23386248)
2013
5
Evaluation of MycAssaya8c Aspergillus for diagnosis of invasive pulmonary aspergillosis in patients without hematological cancer. (23620764)
2013
6
Pharmacokinetics of piperacillin/tazobactam in cancer patients with hematological malignancies and febrile neutropenia after chemotherapy. (24286231)
2013
7
Targeting p53 in vivo: a first-in-human study with p53-targeting compound APR-246 in refractory hematologic malignancies and prostate cancer. (22965953)
2012
8
Thymidylate synthase polymorphisms and hematological cancer risk: a meta-analysis. (22166040)
2012
9
Family history of non-hematologic cancers among Waldenstrom macroglobulinemia patients: a preliminary study. (22099500)
2012
10
A stapled BIM peptide overcomes apoptotic resistance in hematologic cancers. (22622039)
2012
11
Febrile neutropenia incidence and hematological toxicity with the FEC100-docetaxel regimen in the treatment of early-stage breast cancer. (22713627)
2012
12
p53 codon 72 polymorphism and hematological cancer risk: an update meta-analysis. (23029260)
2012
13
A genome-wide association study identifies four genetic markers for hematological toxicities in cancer patients receiving gemcitabine therapy. (22293537)
2012
14
Improving access to information and support for patients with less common cancers: hematologic cancer patients' views about Web-based approaches. (22189354)
2011
15
Physical activity and hematologic cancer prevention. (21113763)
2011
16
Impact of influenza A(H1N1) in pediatric patients with cancer and hematologic disorders: establishment of information sharing system for swine influenza. (22185798)
2011
17
Evolving information priorities of hematologic cancer survivors, caregivers, and other relatives. (20119694)
2010
18
Invasive fusariosis in patients with hematologic malignancies at a cancer center: 1998-2009. (20138081)
2010
19
Mesial temporal sclerosis as a complication of hematologic cancer. (19434437)
2009
20
Managed care considerations: hematologic cancer as a chronic disease. (19119536)
2008
21
Phase 3 trials suggest ways to improve current hematologic cancer therapies. (18252877)
2008
22
Searching for evidence of disease and malignant cell contamination in ovarian tissue stored from hematologic cancer patients. (18344563)
2008
23
Posaconazole prophylaxis in hematologic cancer. (17526090)
2007
24
A yeast two-hybrid system using Sp17 identified ropporin as a novel cancer-testis antigen in hematologic malignancies. (17551920)
2007
25
Wheat grass juice may improve hematological toxicity related to chemotherapy in breast cancer patients: a pilot study. (17571966)
2007
26
Posaconazole prophylaxis in hematologic cancer. (17526089)
2007
27
The BRCA1/2 pathway prevents hematologic cancers in addition to breast and ovarian cancers. (17683622)
2007
28
Posaconazole prophylaxis in hematologic cancer. (17522407)
2007
29
Posaconazole prophylaxis in hematologic cancer. (17526091)
2007
30
Serum Aspergillus galactomannan antigen values strongly correlate with outcome of invasive aspergillosis: a study of 56 patients with hematologic cancer. (17607669)
2007
31
Role of MTHFR (677, 1298) haplotype in the risk of developing secondary leukemia after treatment of breast cancer and hematological malignancies. (17476281)
2007
32
Low mannose-binding lectin concentration is associated with severe infection in patients with hematological cancer who are undergoing chemotherapy. (17516403)
2007
33
Double-blind, placebo-controlled study of quality of life, hematologic end points, and safety of weekly epoetin alfa in children with cancer receiving myelosuppressive chemotherapy. (16877725)
2006
34
Patient-rated emotional and physical functioning among hematologic cancer patients during hospitalization for stem-cell transplantation. (15580279)
2005
35
Impact of five prophylactic filgrastim schedules on hematologic toxicity in early breast cancer patients treated with epirubicin and cyclophosphamide. (16129844)
2005
36
The spermatozoa protein, SLLP1, is a novel cancer-testis antigen in hematologic malignancies. (15475442)
2004
37
In vitro chemosensitivity testing of hematological cancer patients: detection of ornithine decarboxylase. (12528799)
2003
38
Psychiatric morbidity and impact on hospital length of stay among hematologic cancer patients receiving stem-cell transplantation. (11919251)
2002
39
Cytokeratin 20 is not a reliable molecular marker for occult breast cancer cell detection in hematological tissues. (11368411)
2001
40
In vitro chemosensitivity testing of hematological cancers: immunohistochemical detection of ornithine decarboxylase. (10587289)
1999
41
Acute hematologic feasibility of G-CSF supported dose-escalated FEC therapy as adjuvant treatment after breast cancer surgery. (10650787)
1999
42
Bropirimine (U-54461S) early phase II clinical studies--to investigate the efficacy and safety of bropirimine treatment on various malignant tumors (urological, hematologic, and dermal cancers)]. (9020948)
1997
43
Dose escalation of paclitaxel with high-dose cyclophosphamide, with analysis of progenitor-cell mobilization and hematologic support of advanced ovarian cancer patients receiving rapidly sequenced high-dose carboplatin/cyclophosphamide courses. (7537799)
1995
44
Effect of granulocyte-macrophage colony-stimulating factor (GM-CSF) on hematologic toxicity induced by high-dose chemotherapy in patients with metastatic breast cancer. (7492381)
1995
45
Phase I trial of a 90-minute infusion of the fusion toxin DAB486IL-2 in hematological cancers. (8358720)
1993
46
Changes in hematologic parameters during treatment with medroxyprogesterone acetate for breast cancer. (1828463)
1991
47
Recombinant human granulocyte-macrophage colony-stimulating factor reduces hematologic toxicity and widens clinical applicability of high-dose cyclophosphamide treatment in breast cancer and non-Hodgkin's lymphoma. (2185337)
1990
48
Autologous bone marrow transplantation for hematologic cancer. (2236163)
1990
49
Alzheimer's disease and senile dementia: genetic relationships to Down's syndrome and hematologic cancer. (154163)
1979
50
Albinism: hematologic-storage disease, susceptibility to skin cancer, and optic neuronal defects shared in all types of oculocutaneous and ocular albinism. (546241)
1979

Genetic Variations for Hematologic Cancer

Expression for genes affiliated with Hematologic Cancer

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Hematologic Cancer

Search GEO for disease gene expression data for Hematologic Cancer.

Pathways for genes affiliated with Hematologic Cancer

Sources:
52QIAGEN, 38NCBI BioSystems Database, 12EMD Millipore, 54Reactome, 53R&D Systems, 30KEGG, 50PharmGKB, 4Cell Signaling Technology
See all sources

Pathways related to Hematologic Cancer according to GeneCards/GeneDecks:

(show all 38)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4TP53, RB1
2
Hide members
9.3IL2, IL2RA, IL2RB
39.3IL2, IL2RA, IL2RB
4
Hide members
9.3IL2RA, IL2RB, IL2
5
Hide members
9.3IL2RB, IL2RA, IL2
6
Hide members
9.3IL2, IL2RB, IL2RA
79.3IL2, IL2RB, IL2RA
8
Hide members
9.3IL2RB, IL2RA, IL2
9
Immune response IL-2 activation and signaling pathway
Hide members
9.3IL2RA, IL2, IL2RB
109.3IL2RA, IL2RB, IL2
119.3IL2RB, IL2, IL2RA
12
Hide members
9.3IL2RA, IL2RB, IL2
139.2BRCA1, TP53
149.2TP53, BRCA1
159.2CSF3, IL2RA, FCER2
169.2RB1, BRCA1, TYMS
179.0TYMS, TP53
18
Hide members
9.0BRCA1, RB1, TP53
19
Hide members
9.0RB1, BRCA1, TP53
20
Hide members
8.9BRCA2, RB1, TP53
21
Hide members
8.9IL2, IL2RA, FCER2, IL2RB
228.9IL2, RB1, TP53
23
DNA damage Role of Brca1 and Brca2 in DNA repair
Hide members
8.8TP53, BRCA2, BRCA1
24
Hide members
8.8CSF3, TP53, IL2RA
258.7IL2RB, IL2RA, IL2, CSF3
26
Hide members
8.7BRCA2, BRCA1, RB1, TYMS
27
Hide members
8.7RB1, IL2RA, IL2RB, BCL2L11, IL2
288.5BRCA1, RB1, TP53, BRCA2
298.5BRCA1, TP53, RB1, BRCA2
30
Hide members
8.5BRCA1, BRCA2, RB1, TP53
31
Hide members
8.4TP53, IL2RA, IL2RB, IL2
32
Hide members
8.2RB1, IL2RA, IL2, TP53, BCL2L11
338.2IL2RB, TP53, RB1, IL2RA, IL2
348.2TYMS, TP53, BRCA1, BRCA2
35
Hide members
7.9CSF3, IL2RB, IL2RA, TP53, IL2
36
Hide members
7.5IL2, FCER2, TP53, BRCA2, BRCA1, IL2RA
377.2IL2RB, BRCA1, CSF3, BCL2L11, IL2, TP53
38
Hide members
7.0RB1, CSF3, BRCA1, IL2, IL2RA, IL2RB

Compounds for genes affiliated with Hematologic Cancer

Sources:
45Novoseek, 50PharmGKB, 29IUPHAR, 11DrugBank, 60Tocris Bioscience, 24HMDB, 2BitterDB
See all sources

Compounds related to Hematologic Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 155)
idCompoundScoreTop Affiliating Genes
1estrogen4510.6MBL2
2dexamethasone45 50 29 1113.3RB1, FCER2
3resveratrol45 60 11 2413.1ODC1, BRCA2
4serine459.8BRCA1, IL2RB, FCER2
5p003459.8BRCA2, RB1, IL2RB
6cycloheximide459.7BRCA1, BRCA2, IL2RB
7denileukin diftitox45 50 1111.4IL2, IL2RB, IL2RA
8valine459.3PTHLH, ODC1, TYMS
9con a459.3IL2RA, MBL2, IL2, IL2RB
10okt3459.3FCER2, IL2, IL2RB, IL2RA
11adriamycin459.2TYMS, RB1, CSF3, ODC1
122,5-oligoadenylate459.2ODC1, IL2RB, IL2, IL2RA
13tamoxifen45 50 29 1112.2IL2RB, TYMS, IL2, PTHLH
14alemtuzumab45 1110.1IL2RA, CSF3, IL2RB, IL2
15levamisole45 1110.0IL2, IL2RB, IL2RA, TYMS
16neopterin459.0MBL2, IL2RA, FCER2, IL2, IL2RB
17indole-3-carbinol458.7ODC1, BRCA1, BRCA2, TP53
18mycophenolate mofetil45 50 1110.7IL2RA, CSF3, IL2, IL2RB
19aphidicolin458.7RB1, TP53, TYMS, BRCA1
20rapamycin458.7BCL2L11, IL2, ODC1, IL2RB, RB1, IL2RA
21prednisolone45 29 1110.6MBL2, IL2RA, IL2, IL2RB, CSF3, PTHLH
22ionomycin458.6PTHLH, FCER2, IL2RA, IL2RB, IL2
232-chlorodeoxyadenosine458.6TP53, CSF3, IL2RA, IL2
24paraffin458.5MBL2, PTHLH, FCER2, IL2RA, BRCA2, BRCA1
25thymidylate458.4TYMS, ODC1, BRCA1, RB1, TP53
26topotecan45 119.2CSF3, BRCA1, TYMS, TP53
27carboplatin45 50 1110.2CSF3, BRCA1, RB1, TYMS, TP53
28actinomycin d458.2TP53, ODC1, RB1, IL2, BCL2L11, PTHLH
29steroid458.2IL2RB, RB1, MBL2, PTHLH, BRCA2, BRCA1
30camptothecin45 60 1110.2TYMS, TP53, BRCA1, BRCA2, RB1
31bleomycin45 119.1IL2RA, PTHLH, BRCA2, CSF3, BRCA1, TP53
32folate458.0ODC1, IL2RA, BRCA2, BRCA1, TYMS
33progesterone45 60 29 11 2412.0BRCA2, BRCA1, MBL2, TP53, RB1, IL2RB
34genistein45 29 60 2 11 2412.9ODC1, BRCA1, BRCA2, IL2RA, IL2RB, IL2
35docetaxel45 50 60 1110.9BRCA1, BRCA2, TP53, TYMS, CSF3
36h2o2457.9TP53, BCL2L11, RB1, BRCA1, ODC1, BRCA2
37hydroxyurea45 50 119.8ODC1, TP53, TYMS, CSF3, BRCA2, BRCA1
38methotrexate45 50 119.7ODC1, IL2RA, BRCA1, IL2RB, BRCA2, CSF3
39doxorubicin45 50 119.6CSF3, TP53, IL2RA, ODC1, BRCA1, RB1
40vincristine45 50 119.6RB1, IL2RA, TP53, PTHLH, BRCA2, ODC1
415fluorouracil457.4TYMS, TP53, IL2RA, RB1, CSF3, BRCA1
42mitomycin c457.3TP53, TYMS, IL2, RB1, CSF3, BRCA1
43paclitaxel45 50 119.3ODC1, TYMS, BCL2L11, BRCA2, TP53, BRCA1
44retinoic acid45 248.2TP53, FCER2, IL2RB, RB1, BRCA2, CSF3
45etoposide45 50 60 1110.2TYMS, BRCA2, IL2RA, TP53, CSF3, RB1
46cyclophosphamide45 50 119.2TP53, IL2RB, CSF3, IL2RA, IL2, PTHLH
47tyrosine457.0BCL2L11, FCER2, IL2, MBL2, IL2RB, IL2RA
48vegf456.5MBL2, BRCA1, IL2RB, IL2RA, CSF3, TYMS
49cisplatin45 50 60 119.4BRCA1, BRCA2, PTHLH, CSF3, RB1, TYMS
50thymidine45 246.8TP53, PTHLH, FCER2, IL2, IL2RB, IL2RA

GO Terms for genes affiliated with Hematologic Cancer

Sources:
16Gene Ontology
See all sources

Biological processes related to Hematologic Cancer according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1regulation of T cell homeostatic proliferationGO:0460139.8IL2, IL2RA
2regulation of transcription involved in G1/S transition of mitotic cell cycleGO:0000839.6TYMS, RB1
3positive regulation of cell cycle arrestGO:0711589.3TP53, BRCA1
4positive regulation of activated T cell proliferationGO:0421049.3IL2, IL2RA
5response to X-rayGO:0101659.1TP53, BRCA2
6DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.0TP53, BRCA2, BRCA1
7double-strand break repairGO:0063028.9BRCA1, BRCA2, TP53
8positive regulation of cell proliferationGO:0082848.9ODC1, CSF3, IL2, PTHLH
9positive regulation of transcription from RNA polymerase II promoterGO:0459448.1BRCA1, CSF3, RB1, IL2, TP53

Molecular functions related to Hematologic Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-2 bindingGO:0199769.8IL2RB, IL2RA
2interleukin-2 receptor activityGO:0049119.5IL2RB, IL2RA

Products for genes affiliated with Hematologic Cancer

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hematologic Cancer

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet