MCID: HMT002
MIFTS: 52

Hematologic Cancer malady

Immune diseases, Blood diseases, Cancer diseases categories

Summaries for Hematologic Cancer

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Disease Ontology:9 An immune system cancer located in the hematological system that is characterized by uncontrolled cellular proliferation in blood, bone marrow and lymph nodes.

MalaCards based summary: Hematologic Cancer, also known as hematologic neoplasm, is related to paraneoplastic syndromes and aplastic anemia. An important gene associated with Hematologic Cancer is PTHLH (parathyroid hormone-like hormone), and among its related pathways are Apoptosis and survival Caspase cascade and FOXM1 transcription factor network. The compounds gossypol and teniposide have been mentioned in the context of this disorder. Affiliated tissues include the hematological system, bone and bone marrow, and related mouse phenotypes are pigmentation and adipose tissue.

Aliases & Classifications for Hematologic Cancer

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Hematologic Cancer, Aliases & Descriptions:

Name: Hematologic Cancer 30 9 43
Hematologic Neoplasm 9 22
Malignant Tumor of Lymphoid Hemopoietic and Related Tissue 60
Hematopoietic and Lymphoid System Tumor 9
Malignant Hematopoietic Neoplasm 9
Hematologic Malignancies 43
Hematopoietic Neoplasms 60
 
Hematologic Malignancy 9
Hematopoietic Neoplasm 9
Hematologic Neoplasms 60
Hematopoietic Tumors 9
Hematological Tumors 9
Hematopoietic Cancer 9
Blood Cancer 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Immune diseases, Blood diseases


External Ids:

Disease Ontology9 DOID:2531
NCIt38 C27134
MeSH33 D019337

Related Diseases for Hematologic Cancer

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Diseases related to Hematologic Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 230)
idRelated DiseaseScoreTop Affiliating Genes
1paraneoplastic syndromes30.6PTHLH, CSF3
2aplastic anemia30.4BRCA1, BRCA2
3hodgkin lymphoma30.0CSF3, BRCA1, BRCA2
4chronic lymphocytic leukemia30.0RB1, BRCA2
5myeloma29.9PTHLH, BCL2L11, CSF3, RB1
6breast cancer29.8BRCA1, BRCA2
7retinoblastoma29.6BRCA2, BRCA1, RB1
8burkitt lymphoma29.3RB1, CSF3, BCL2L11, BRCA2, PTHLH
9prostate cancer29.1PTHLH, BRCA2, BRCA1, BCL2L11, RB1
10leukemia29.0BRCA2, BRCA1, BCL2L11, CSF3, RB1
11hematopoietic stem cell transplantation10.6
12neutropenia10.5
13bacteremia10.4
14b-cell lymphomas10.4
15zygomycosis10.4
16lung cancer10.4CSF3
17hyperuricemia10.3
18fusariosis10.3
19endotheliitis10.3
20myelodysplastic syndrome10.3
21mantle cell lymphoma10.3
22pulmonary alveolar proteinosis10.3
23candidiasis10.3
24central nervous system hematologic cancer10.3
25refractory hematologic cancer10.3
26hereditary breast ovarian cancer10.3BRCA2
27multiple myeloma10.2
28diffuse large b-cell lymphoma10.2
29hepatitis10.2
30lymphoblastic lymphoma10.2
31systemic mastocytosis10.2
32strongyloidiasis10.2
33disseminated intravascular coagulation10.2
34eosinophilia10.2
35mediastinitis10.2
36pneumonia10.2
37rhabdomyosarcoma10.2
38sarcoma10.2
39thyroiditis10.2
40acute graft versus host disease10.2
41mastocytosis10.2
42hemoglobin c disease10.2
43bone cancer10.1RB1, PTHLH
44systemic lupus erythematosus10.1
45mismatch repair cancer syndrome10.1
46leukemia, acute myeloid10.1
47acute biphenotypic leukemia10.1
48acute erythroid leukemia10.1
49adult acute lymphocytic leukemia10.1
50adult t-cell leukemia10.1

Graphical network of the top 20 diseases related to Hematologic Cancer:



Diseases related to hematologic cancer

Symptoms for Hematologic Cancer

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Drugs & Therapeutics for Hematologic Cancer

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Drug clinical trials:

Search ClinicalTrials for Hematologic Cancer

Search NIH Clinical Center for Hematologic Cancer

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Hematologic Cancer cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Hematologic Cancer:
ALD-151, umbilical cord blood cells for hematologic and immunodefeciency diseases
Allocord, cord blood-derived hematopoietic progenitor cells for hematopoietic reconstitution
Co-infusion of umbilical cord blood and haploidentical CD34+ cells for hematological diseases
Ducord, umbilical cord blood-derived hematopoietic progenitor cells for hematopoietic reconstitution
Expanded cord blood hematopoietic stem cells for hematologic malignancies
Hemacord
Hematopoietic stem cells for treatment of hematologic malignancies
StemEx
Umbilical cord blood-derived hematopoietic progenitor cells for hematopoietic reconstitution
Umbilical cord blood-derived hematopoietic progenitor cells for hematopoietic reconstitution
Embryonic/Adult Cultured Cells Related to Hematologic Cancer:
Umbilical cord blood ALDH+ cells (ALD-151), PMID: 10430905
Umbilical cord blood-derived hematopoietic progenitor cells (Allocord), PMID: 11953027
Peripheral blood-derived hematopoietic stem cells
Umbilical cord blood-derived hematopoietic progenitor cells (Ducord), PMIDs: 22698485, 21810098, 23711284, 21277377
Mesenchymal Precursor Cells (STRO-3 selected), PMID: 21396596
Expanded umbilical cord blood-derived hematopoietic stem cells, PMID: 21396596
Umbilical cord blood-derived hematopoietic progenitor cells (HEMACORD, PMID: 9828244
Bone marrow-derived hematopoietic stem cells
Umbilical cord blood stem/progenitor cells (Stemex), PMID: 18209724
Umbilical cord blood stem/progenitor cells (Stemex), PMID: 18209724
Umbilical cord blood-derived hematopoietic stem cells (family), PMID: 20676147
Umbilical cord blood-derived hematopoietic stem cells (family)

Genetic Tests for Hematologic Cancer

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Genetic tests related to Hematologic Cancer:

id Genetic test Affiliating Genes
1 Hematologic Neoplasm22

Anatomical Context for Hematologic Cancer

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MalaCards organs/tissues related to Hematologic Cancer:

31
Bone, Bone marrow, Lymph node, Testes, Heart, Breast, Myeloid

FMA organs/tissues related to Hematologic Cancer:

14
The hematological system

Animal Models for Hematologic Cancer or affiliated genes

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Publications for Hematologic Cancer

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Articles related to Hematologic Cancer:

(show all 34)
idTitleAuthorsYear
1
Hospitalization risk according to geriatric assessment and laboratory parameters in elderly hematologic cancer patients. (25684525)
2015
2
Survivorship Care Plans and Treatment Summaries a8"in Adult Patients With Hematologic Cancer: a8"An Integrative Literature Review. (25901380)
2015
3
The microfluidic multitrap nanophysiometer for hematologic cancer cell characterization reveals temporal sensitivity of the calcein-AM efflux assay. (24873950)
2014
4
Design of a cost-effectiveness analysis alongside a randomized trial of transplantation using umbilical cord blood versus HLA-haploidentical related bone marrow in advanced hematologic cancer. (24645687)
2014
5
Combination of vaccine-strain measles and mumps virus synergistically kills a wide range of human hematological cancer cells: Special focus on acute myeloid leukemia. (25193462)
2014
6
The falling incidence of hematologic cancer after heart transplantation. (25100534)
2014
7
Confirmation of the reported association of clonal chromosomal mosaicism with an increased risk of incident hematologic cancer. (23533652)
2013
8
Internet-based program for coping with cancer: a randomized controlled trial with hematologic cancer patients. (22565413)
2013
9
Xist RNA is a potent suppressor of hematologic cancer in mice. (23415223)
2013
10
Evaluation of MycAssaya8c Aspergillus for diagnosis of invasive pulmonary aspergillosis in patients without hematological cancer. (23620764)
2013
11
Thymidylate synthase polymorphisms and hematological cancer risk: a meta-analysis. (22166040)
2012
12
Family history of non-hematologic cancers among Waldenstrom macroglobulinemia patients: a preliminary study. (22099500)
2012
13
p53 codon 72 polymorphism and hematological cancer risk: an update meta-analysis. (23029260)
2012
14
Improving access to information and support for patients with less common cancers: hematologic cancer patients' views about Web-based approaches. (22189354)
2011
15
Physical activity and hematologic cancer prevention. (21113763)
2011
16
Mesial temporal sclerosis as a complication of hematologic cancer. (19434437)
2009
17
Managed care considerations: hematologic cancer as a chronic disease. (19119536)
2008
18
Phase 3 trials suggest ways to improve current hematologic cancer therapies. (18252877)
2008
19
Femoral resurfacing in young patients with hematologic cancer and osteonecrosis. (18679763)
2008
20
Searching for evidence of disease and malignant cell contamination in ovarian tissue stored from hematologic cancer patients. (18344563)
2008
21
Posaconazole prophylaxis in hematologic cancer. (17526090)
2007
22
Posaconazole prophylaxis in hematologic cancer. (17526089)
2007
23
The BRCA1/2 pathway prevents hematologic cancers in addition to breast and ovarian cancers. (17683622)
2007
24
Posaconazole prophylaxis in hematologic cancer. (17522407)
2007
25
Posaconazole prophylaxis in hematologic cancer. (17526091)
2007
26
Serum Aspergillus galactomannan antigen values strongly correlate with outcome of invasive aspergillosis: a study of 56 patients with hematologic cancer. (17607669)
2007
27
Low mannose-binding lectin concentration is associated with severe infection in patients with hematological cancer who are undergoing chemotherapy. (17516403)
2007
28
Patient-rated emotional and physical functioning among hematologic cancer patients during hospitalization for stem-cell transplantation. (15580279)
2005
29
In vitro chemosensitivity testing of hematological cancer patients: detection of ornithine decarboxylase. (12528799)
2003
30
Psychiatric morbidity and impact on hospital length of stay among hematologic cancer patients receiving stem-cell transplantation. (11919251)
2002
31
In vitro chemosensitivity testing of hematological cancers: immunohistochemical detection of ornithine decarboxylase. (10587289)
1999
32
Phase I trial of a 90-minute infusion of the fusion toxin DAB486IL-2 in hematological cancers. (8358720)
1993
33
Autologous bone marrow transplantation for hematologic cancer. (2236163)
1990
34
Alzheimer's disease and senile dementia: genetic relationships to Down's syndrome and hematologic cancer. (154163)
1979

Variations for Hematologic Cancer

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Expression for genes affiliated with Hematologic Cancer

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Search GEO for disease gene expression data for Hematologic Cancer.

Pathways for genes affiliated with Hematologic Cancer

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Pathways related to Hematologic Cancer according to GeneCards Suite gene sharing:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
FAS pathway and Stress induction of HSP regulation36
Apoptosis and survival FAS signaling cascades58
Caspase cascade in apoptosis36
9.5RB1, BCL2L11
29.4BRCA2, RB1
3
Show member pathways
9.4RB1, BRCA2
49.2RB1, BRCA1
59.2BRCA1, RB1
6
Show member pathways
9.2RB1, BRCA1
7
Show member pathways
DNA damage response36
9.2RB1, BRCA1
8
Show member pathways
Prostate Cancer36
Integrated Cancer pathway36
Steroid Biosynthesis36
9.2BRCA1, RB1
9
Show member pathways
9.0BRCA1, BRCA2
109.0BRCA1, BRCA2
119.0BRCA1, BRCA2
12
Show member pathways
9.0BRCA2, BRCA1
13
Show member pathways
9.0BRCA1, BRCA2
14
Show member pathways
9.0BRCA1, BRCA2
158.6CSF3, BCL2L11, BRCA1
16
Show member pathways
Signaling Pathways in Glioblastoma36
8.6RB1, BRCA1, BRCA2
17
Show member pathways
8.6RB1, BRCA1, BRCA2
188.6RB1, BRCA1, BRCA2
19
Show member pathways
8.6BRCA2, BRCA1, RB1
20
Show member pathways
8.6BRCA2, BRCA1, RB1
21
Show member pathways
8.2BRCA1, BCL2L11, CSF3, RB1

Compounds for genes affiliated with Hematologic Cancer

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Compounds related to Hematologic Cancer according to GeneCards Suite gene sharing:

(show top 50)    (show all 73)
idCompoundScoreTop Affiliating Genes
1gossypol439.8BCL2L11, RB1
2teniposide43 1210.8RB1, CSF3
3vinorelbine43 49 1211.3CSF3, BRCA1
48-oxoguanine439.3BRCA1, BRCA2
5aphidicolin439.3RB1, BRCA1
6daidzein439.3BRCA1, BRCA2
7matrigel439.2BRCA2, RB1, PTHLH
8lycopene43 2410.2BRCA1, BRCA2
9agar439.1RB1, PTHLH, BRCA1
10actinomycin d439.1RB1, PTHLH, BCL2L11
11carboplatin43 49 1211.1RB1, CSF3, BRCA1
12platinum43 4910.0CSF3, BRCA1
13indole-3-carbinol439.0BRCA2, BRCA1
145fluorouracil439.0RB1, CSF3, BRCA1
15adpribose439.0RB1, BRCA2, BRCA1
16p003439.0BRCA1, BRCA2, RB1
17p002439.0RB1, BRCA1, BRCA2
18resveratrol43 59 24 1212.0BRCA1, RB1, BRCA2
19camptothecin43 59 1210.9RB1, BRCA1, BRCA2
20hydroxyurea43 49 1210.9BRCA2, BRCA1, CSF3
21dexamethasone43 49 28 1211.9RB1, PTHLH, BCL2L11, CSF3
22polyacrylamide438.9BRCA2, BRCA1, RB1
23docetaxel43 49 59 1211.9BRCA1, CSF3, BRCA2
24tamoxifen43 49 28 1211.8PTHLH, BRCA2, BRCA1
25doxorubicin43 49 1210.8BRCA1, CSF3, RB1
26cyclophosphamide43 49 1210.7BRCA1, CSF3, PTHLH, RB1
27vegf438.6RB1, PTHLH, BRCA1, CSF3
28estradiol43 24 1210.6PTHLH, BRCA2, BRCA1, RB1
29paraffin438.6BRCA2, BRCA1, PTHLH, RB1
30progesterone43 28 59 24 1212.6BRCA1, PTHLH, BRCA2, RB1
31bleomycin43 129.5BRCA2, BRCA1, CSF3, PTHLH
32oxygen43 249.5BCL2L11, RB1, BRCA1, PTHLH
33testosterone43 59 24 1211.5BRCA1, BRCA2, PTHLH, RB1
34steroid438.5PTHLH, BRCA2, BRCA1, RB1
35mitomycin c438.5CSF3, BRCA2, RB1, BRCA1
36adriamycin438.5BRCA2, BRCA1, CSF3, RB1
37methotrexate49 43 1210.5BRCA1, RB1, CSF3, BRCA2
38h2o2438.4BRCA1, BRCA2, BCL2L11, RB1
39oligonucleotide438.4BRCA2, RB1, BRCA1, BCL2L11
40genistein43 28 59 2 24 1213.3BRCA2, BRCA1, RB1
41tyrosine438.1CSF3, BCL2L11, BRCA1, PTHLH, RB1
42vincristine43 49 1210.1PTHLH, RB1, BRCA2, BRCA1, CSF3
43thymidine43 249.1RB1, BRCA1, BRCA2, PTHLH, CSF3
44cisplatin43 49 59 1211.1BRCA2, CSF3, PTHLH, BRCA1, RB1
45phosphatidylinositol438.1BRCA1, PTHLH, BRCA2, BCL2L11, RB1
46estrogen438.1PTHLH, RB1, BRCA1, BRCA2, BCL2L11
47retinoic acid43 249.1BRCA1, RB1, CSF3, BRCA2, PTHLH
48cycloheximide438.0BRCA2, PTHLH, BCL2L11, CSF3, BRCA1
49etoposide43 49 59 1211.0BRCA2, CSF3, RB1, BCL2L11, BRCA1
50paclitaxel43 49 129.6BRCA1, RB1, CSF3, BCL2L11, BRCA2, PTHLH

GO Terms for genes affiliated with Hematologic Cancer

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Biological processes related to Hematologic Cancer according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of sequence-specific DNA binding transcription factor activityGO:00434339.7RB1, PTHLH
2androgen receptor signaling pathwayGO:00305219.3RB1, BRCA1
3intrinsic apoptotic signaling pathway in response to DNA damageGO:00086309.2BCL2L11, BRCA1
4DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00069789.2BRCA1, BRCA2
5double-strand break repair via homologous recombinationGO:00007248.9BRCA1, BRCA2
6double-strand break repairGO:00063028.7BRCA1, BRCA2
7positive regulation of transcription from RNA polymerase II promoterGO:00459448.7RB1, CSF3, BRCA1
8positive regulation of transcription, DNA-templatedGO:00458938.6BRCA2, BRCA1, RB1

Molecular functions related to Hematologic Cancer according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1androgen receptor bindingGO:00506819.2RB1, BRCA1

Products for genes affiliated with Hematologic Cancer

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Hematologic Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet