MCID: HMT002
MIFTS: 61

Hematologic Cancer malady

Cancer diseases, Immune diseases, Blood diseases categories
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Summaries for Hematologic Cancer

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Sources:
8Disease Ontology, 65Wikipedia, 33MalaCards
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Disease Ontology:8 An immune system cancer located in the hematological system that is characterized by uncontrolled cellular proliferation in blood, bone marrow and lymph nodes.

MalaCards: Hematologic Cancer, also known as hematologic neoplasm, is related to paraneoplastic syndromes and aplastic anemia. An important gene associated with Hematologic Cancer is PTHLH (parathyroid hormone-like hormone), and among its related pathways are Apoptosis and survival Caspase cascade and FOXM1 transcription factor network. The compounds gossypol and teniposide have been mentioned in the context of this disorder. Affiliated tissues include the hematological system, bone and bone marrow, and related mouse phenotypes are pigmentation and adipose tissue.

Wikipedia:65 Tumors of the hematopoietic and lymphoid tissues or haematopoietic and lymphoid malignancies are tumors... more...

Aliases & Classifications for Hematologic Cancer

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Sources:
8Disease Ontology, 22GTR, 45Novoseek, 31LifeMap Discovery™, 62UMLS, 40NCIt, 58SNOMED-CT, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Immune diseases, Blood diseases


Aliases & Descriptions:

hematologic cancer 8 45 31
hematologic neoplasm 8 22
hematopoietic and lymphoid system tumor 8
malignant hematopoietic neoplasm 8
hematologic malignancies 45
hematopoietic neoplasms 62
hematologic malignancy 8
hematopoietic neoplasm 8
hematologic neoplasms 62
hematopoietic tumors 8
hematopoietic cancer 8
hematological tumors 8
blood cancer 8


External Ids:

Disease Ontology8 DOID:2531
NCIt40 C27134
MeSH35 D019337

Related Diseases for Hematologic Cancer

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Hematologic Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 231)
idRelated DiseaseScoreTop Affiliating Genes
1paraneoplastic syndromes30.4PTHLH, CSF3
2aplastic anemia30.3BRCA1, BRCA2
3hodgkin's lymphoma30.1CSF3, BRCA1, BRCA2
4leukemia30.0BRCA2, BRCA1, BCL2L11, CSF3, RB1
5acute lymphocytic leukemia29.9RB1, CSF3, PTHLH
6breast cancer29.9BRCA1, BRCA2
7myeloma29.9PTHLH, BCL2L11, CSF3, RB1
8retinoblastoma29.9BRCA2, BRCA1, RB1
9ovarian cancer29.8BRCA2, BRCA1, CSF3, RB1
10prostate cancer29.7PTHLH, BRCA2, BRCA1, BCL2L11, RB1
11burkitt's lymphoma29.7RB1, CSF3, BCL2L11, BRCA2, PTHLH
12hematopoietic stem cell transplantation10.5
13neutropenia10.4
14b-cell lymphomas10.4
15graft versus host disease10.4
16zygomycosis10.4
17bacteremia10.4
18hyperuricemia10.3
19fusariosis10.3
20acute myeloid leukemia10.3
21mantle cell lymphoma10.3
22candidiasis10.3
23myelodysplastic syndromes10.3
24endotheliitis10.3
25strongyloidiasis10.2
26pulmonary alveolar proteinosis10.2
27diffuse large b-cell lymphoma10.2
28chronic lymphocytic leukemia10.2
29disseminated intravascular coagulation10.2
30eosinophilia10.2
31hairy cell leukemia10.2
32hepatitis10.2
33multiple myeloma10.2
34pneumonia10.2
35thyroiditis10.2
36acute graft versus host disease10.2
37lymphoblastic lymphoma10.2
38germ cell tumors10.2
39sepsis10.2
40hemoglobin c disease10.2
41central nervous system hematologic cancer10.2
42refractory hematologic cancer10.2
43megakaryocytic leukemia10.1
44neurofibromatosis10.1
45autoimmune thyroiditis10.1
46follicular lymphoma10.1
47pyomyositis10.1
48hypercalcemia10.1
49systemic lupus erythematosus10.1
50adult t-cell leukemia10.1

Graphical network of the top 20 diseases related to Hematologic Cancer:



Diseases related to hematologic cancer

Symptoms for Hematologic Cancer

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Drugs & Therapeutics for Hematologic Cancer

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 62UMLS, 41NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Hematologic Cancer

Search NIH Clinical Center for Hematologic Cancer

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Hematologic Cancer cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Hematologic Cancer:
ALD-151, umbilical cord blood cells for hematologic and immunodefeciency diseases
Allocord, cord blood-derived hematopoietic progenitor cells for hematopoietic reconstitution
Co-infusion of umbilical cord blood and haploidentical CD34+ cells for hematological diseases
Ducord, umbilical cord blood-derived hematopoietic progenitor cells for hematopoietic reconstitution
Expanded cord blood hematopoietic stem cells for hematologic malignancies
Hemacord
Hematopoietic stem cells for treatment of hematologic malignancies
StemEx
Umbilical cord blood-derived hematopoietic progenitor cells for hematopoietic reconstitution
Umbilical cord blood-derived hematopoietic progenitor cells for hematopoietic reconstitution
Embryonic/Adult Cultured Cells Related to Hematologic Cancer:
Umbilical cord blood ALDH+ cells (ALD-151), PMID: 10430905
Umbilical cord blood-derived hematopoietic progenitor cells (Allocord), PMID: 11953027
Peripheral blood-derived hematopoietic stem cells
Umbilical cord blood-derived hematopoietic progenitor cells (Ducord), PMIDs: 22698485, 21810098, 23711284, 21277377
Mesenchymal Precursor Cells (STRO-3 selected), PMID: 21396596
Expanded umbilical cord blood-derived hematopoietic stem cells, PMID: 21396596
Umbilical cord blood-derived hematopoietic progenitor cells (HEMACORD, PMID: 9828244
Bone marrow-derived hematopoietic stem cells
Umbilical cord blood stem/progenitor cells (Stemex), PMID: 18209724
Umbilical cord blood stem/progenitor cells (Stemex), PMID: 18209724
Umbilical cord blood-derived hematopoietic stem cells (family), PMID: 20676147
Umbilical cord blood-derived hematopoietic stem cells (family)

Genetic Tests for Hematologic Cancer

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Sources:
22GTR
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Genetic tests related to Hematologic Cancer:

id Genetic test Affiliating Genes
1 Hematologic Neoplasm22

Anatomical Context for Hematologic Cancer

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Sources:
33MalaCards, 14FMA
See all sources

MalaCards organs/tissues related to Hematologic Cancer:

33
Bone, Bone marrow, Lymph node, Testes, Breast

FMA organs/tissues related to Hematologic Cancer:

14
The hematological system

Animal Models for Hematologic Cancer or affiliated genes

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Sources:
37MGI
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Publications for Hematologic Cancer

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Sources:
52PubMed
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Articles related to Hematologic Cancer:

(show all 30)
idTitleAuthorsYear
1
Confirmation of the reported association of clonal chromosomal mosaicism with an increased risk of incident hematologic cancer. (23533652)
2013
2
Internet-based program for coping with cancer: a randomized controlled trial with hematologic cancer patients. (22565413)
2013
3
Xist RNA is a potent suppressor of hematologic cancer in mice. (23415223)
2013
4
Evaluation of MycAssaya8c Aspergillus for diagnosis of invasive pulmonary aspergillosis in patients without hematological cancer. (23620764)
2013
5
Thymidylate synthase polymorphisms and hematological cancer risk: a meta-analysis. (22166040)
2012
6
Family history of non-hematologic cancers among Waldenstrom macroglobulinemia patients: a preliminary study. (22099500)
2012
7
A stapled BIM peptide overcomes apoptotic resistance in hematologic cancers. (22622039)
2012
8
p53 codon 72 polymorphism and hematological cancer risk: an update meta-analysis. (23029260)
2012
9
Improving access to information and support for patients with less common cancers: hematologic cancer patients' views about Web-based approaches. (22189354)
2011
10
Physical activity and hematologic cancer prevention. (21113763)
2011
11
Evolving information priorities of hematologic cancer survivors, caregivers, and other relatives. (20119694)
2010
12
Mesial temporal sclerosis as a complication of hematologic cancer. (19434437)
2009
13
Managed care considerations: hematologic cancer as a chronic disease. (19119536)
2008
14
Phase 3 trials suggest ways to improve current hematologic cancer therapies. (18252877)
2008
15
Femoral resurfacing in young patients with hematologic cancer and osteonecrosis. (18679763)
2008
16
Searching for evidence of disease and malignant cell contamination in ovarian tissue stored from hematologic cancer patients. (18344563)
2008
17
Posaconazole prophylaxis in hematologic cancer. (17526090)
2007
18
Posaconazole prophylaxis in hematologic cancer. (17526089)
2007
19
The BRCA1/2 pathway prevents hematologic cancers in addition to breast and ovarian cancers. (17683622)
2007
20
Posaconazole prophylaxis in hematologic cancer. (17522407)
2007
21
Posaconazole prophylaxis in hematologic cancer. (17526091)
2007
22
Serum Aspergillus galactomannan antigen values strongly correlate with outcome of invasive aspergillosis: a study of 56 patients with hematologic cancer. (17607669)
2007
23
Low mannose-binding lectin concentration is associated with severe infection in patients with hematological cancer who are undergoing chemotherapy. (17516403)
2007
24
Patient-rated emotional and physical functioning among hematologic cancer patients during hospitalization for stem-cell transplantation. (15580279)
2005
25
In vitro chemosensitivity testing of hematological cancer patients: detection of ornithine decarboxylase. (12528799)
2003
26
Psychiatric morbidity and impact on hospital length of stay among hematologic cancer patients receiving stem-cell transplantation. (11919251)
2002
27
In vitro chemosensitivity testing of hematological cancers: immunohistochemical detection of ornithine decarboxylase. (10587289)
1999
28
Phase I trial of a 90-minute infusion of the fusion toxin DAB486IL-2 in hematological cancers. (8358720)
1993
29
Autologous bone marrow transplantation for hematologic cancer. (2236163)
1990
30
Alzheimer's disease and senile dementia: genetic relationships to Down's syndrome and hematologic cancer. (154163)
1979

Variations for Hematologic Cancer

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Expression for genes affiliated with Hematologic Cancer

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hematologic Cancer

Search GEO for disease gene expression data for Hematologic Cancer.

Pathways for genes affiliated with Hematologic Cancer

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Sources:
50PathCards, 60Thomson Reuters, 55Reactome, 38NCBI BioSystems Database, 30KEGG, 53QIAGEN, 57SinoBiological, 12EMD Millipore, 5Cell Signaling Technology
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Pathways related to Hematologic Cancer according to GeneCards/GeneDecks:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
FAS pathway and Stress induction of HSP regulation38
Apoptosis and survival FAS signaling cascades60
Caspase cascade in apoptosis38
9.5RB1, BCL2L11
29.4BRCA2, RB1
3
Show member pathways
9.4RB1, BRCA2
49.2RB1, BRCA1
59.2BRCA1, RB1
6
Show member pathways
9.2RB1, BRCA1
7
Show member pathways
DNA damage response38
9.2RB1, BRCA1
8
Show member pathways
Prostate Cancer38
Integrated Cancer pathway38
Steroid Biosynthesis38
9.2BRCA1, RB1
9
Show member pathways
9.0BRCA1, BRCA2
10
Show member pathways
9.0BRCA1, BRCA2
119.0BRCA1, BRCA2
129.0BRCA1, BRCA2
13
Show member pathways
9.0BRCA2, BRCA1
14
Show member pathways
9.0BRCA1, BRCA2
15
Show member pathways
9.0BRCA1, BRCA2
168.6CSF3, BCL2L11, BRCA1
17
Show member pathways
Signaling Pathways in Glioblastoma38
8.6RB1, BRCA1, BRCA2
18
Show member pathways
8.6RB1, BRCA1, BRCA2
198.6RB1, BRCA1, BRCA2
20
Show member pathways
8.6BRCA2, BRCA1, RB1
21
Show member pathways
8.6BRCA2, BRCA1, RB1
22
Show member pathways
8.2BRCA1, BCL2L11, CSF3, RB1

Compounds for genes affiliated with Hematologic Cancer

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Sources:
45Novoseek, 11DrugBank, 51PharmGKB, 24HMDB, 61Tocris Bioscience, 29IUPHAR, 3BitterDB
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Compounds related to Hematologic Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 73)
idCompoundScoreTop Affiliating Genes
1gossypol459.8RB1, BCL2L11
2teniposide45 1110.8RB1, CSF3
3vinorelbine45 51 1111.3CSF3, BRCA1
48-oxoguanine459.3BRCA2, BRCA1
5aphidicolin459.3RB1, BRCA1
6daidzein459.3BRCA2, BRCA1
7matrigel459.2RB1, BRCA2, PTHLH
8lycopene45 2410.2BRCA1, BRCA2
9agar459.1PTHLH, BRCA1, RB1
10actinomycin d459.1PTHLH, BCL2L11, RB1
11carboplatin45 51 1111.1RB1, CSF3, BRCA1
12platinum45 5110.0CSF3, BRCA1
13indole-3-carbinol459.0BRCA1, BRCA2
145fluorouracil459.0BRCA1, CSF3, RB1
15adpribose459.0BRCA2, BRCA1, RB1
16p003459.0RB1, BRCA1, BRCA2
17p002459.0BRCA2, BRCA1, RB1
18resveratrol45 61 24 1112.0BRCA2, BRCA1, RB1
19camptothecin45 61 1110.9BRCA2, BRCA1, RB1
20hydroxyurea45 51 1110.9CSF3, BRCA1, BRCA2
21dexamethasone45 51 29 1111.9PTHLH, BCL2L11, CSF3, RB1
22polyacrylamide458.9BRCA2, BRCA1, RB1
23docetaxel45 51 61 1111.9BRCA2, BRCA1, CSF3
24tamoxifen45 51 29 1111.8PTHLH, BRCA2, BRCA1
25doxorubicin45 51 1110.8BRCA1, CSF3, RB1
26cyclophosphamide45 51 1110.7PTHLH, BRCA1, CSF3, RB1
27vegf458.6RB1, CSF3, BRCA1, PTHLH
28estradiol45 24 1110.6PTHLH, BRCA2, BRCA1, RB1
29paraffin458.6PTHLH, BRCA2, BRCA1, RB1
30progesterone45 29 61 24 1112.6RB1, BRCA1, BRCA2, PTHLH
31bleomycin45 119.5CSF3, BRCA1, BRCA2, PTHLH
32oxygen45 249.5PTHLH, BRCA1, BCL2L11, RB1
33testosterone45 61 24 1111.5RB1, BRCA1, BRCA2, PTHLH
34steroid458.5RB1, BRCA1, BRCA2, PTHLH
35mitomycin c458.5BRCA2, BRCA1, CSF3, RB1
36adriamycin458.5RB1, CSF3, BRCA1, BRCA2
37methotrexate51 45 1110.5RB1, CSF3, BRCA1, BRCA2
38h2o2458.4RB1, BCL2L11, BRCA1, BRCA2
39oligonucleotide458.4BRCA2, BRCA1, BCL2L11, RB1
40genistein45 29 61 3 24 1113.3RB1, BRCA1, BRCA2
41tyrosine458.1PTHLH, BRCA1, BCL2L11, CSF3, RB1
42vincristine45 51 1110.1PTHLH, BRCA2, BRCA1, CSF3, RB1
43thymidine45 249.1RB1, CSF3, BRCA1, BRCA2, PTHLH
44cisplatin45 51 61 1111.1PTHLH, BRCA2, BRCA1, CSF3, RB1
45phosphatidylinositol458.1PTHLH, BRCA2, BRCA1, BCL2L11, RB1
46estrogen458.1PTHLH, BRCA2, BRCA1, BCL2L11, RB1
47retinoic acid45 249.1RB1, CSF3, BRCA1, BRCA2, PTHLH
48cycloheximide458.0PTHLH, BRCA2, BRCA1, BCL2L11, CSF3
49etoposide45 51 61 1111.0BRCA2, BRCA1, BCL2L11, CSF3, RB1
50paclitaxel45 51 119.6RB1, CSF3, BCL2L11, BRCA1, BRCA2, PTHLH

GO Terms for genes affiliated with Hematologic Cancer

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16Gene Ontology
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Biological processes related to Hematologic Cancer according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of sequence-specific DNA binding transcription factor activityGO:0434339.7RB1, PTHLH
2androgen receptor signaling pathwayGO:0305219.3RB1, BRCA1
3intrinsic apoptotic signaling pathway in response to DNA damageGO:0086309.2BCL2L11, BRCA1
4DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.2BRCA1, BRCA2
5double-strand break repair via homologous recombinationGO:0007248.9BRCA1, BRCA2
6double-strand break repairGO:0063028.7BRCA1, BRCA2
7positive regulation of transcription from RNA polymerase II promoterGO:0459448.7RB1, CSF3, BRCA1
8positive regulation of transcription, DNA-templatedGO:0458938.6BRCA2, BRCA1, RB1

Molecular functions related to Hematologic Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1androgen receptor bindingGO:0506819.2RB1, BRCA1

Products for genes affiliated with Hematologic Cancer

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hematologic Cancer

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet