MCID: HMT002
MIFTS: 63

Hematologic Cancer malady

Cancer diseases, Immune diseases, Blood diseases categories
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Summaries for Hematologic Cancer

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Disease Ontology:8 An immune system cancer located in the hematological system that is characterized by uncontrolled cellular proliferation in blood, bone marrow and lymph nodes.

MalaCards based summary: Hematologic Cancer, also known as hematologic malignancies, is related to paraneoplastic syndromes and aplastic anemia. An important gene associated with Hematologic Cancer is PTHLH (parathyroid hormone-like hormone), and among its related pathways are Apoptosis and survival Caspase cascade and FOXM1 transcription factor network. The compounds gossypol and teniposide have been mentioned in the context of this disorder. Affiliated tissues include the hematological system, bone and bone marrow, and related mouse phenotypes are pigmentation and adipose tissue.

Wikipedia:65 Tumors of the hematopoietic and lymphoid tissues or haematopoietic and lymphoid malignancies are tumors... more...

Aliases & Classifications for Hematologic Cancer

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Hematologic Cancer, Aliases & Descriptions:

Name: Hematologic Cancer 30 8 44
Hematologic Malignancies 44 62
Hematologic Neoplasm 8 22
Hematopoietic and Lymphoid System Tumor 8
Malignant Haematopoietic Neoplasm 62
Malignant Hematopoietic Neoplasm 8
Haematologic Malignancy 62
Hematopoietic Neoplasms 62
 
Hematopoietic Neoplasm 8
Hematologic Malignancy 8
Hematologic Neoplasms 62
Hematopoietic Tumors 8
Hematological Tumors 8
Hematopoietic Cancer 8
Blood Cancer 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Immune diseases, Blood diseases


External Ids:

Disease Ontology8 DOID:2531
NCIt39 C27134
MeSH34 D019337

Related Diseases for Hematologic Cancer

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Diseases related to Hematologic Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 239)
idRelated DiseaseScoreTop Affiliating Genes
1paraneoplastic syndromes30.6PTHLH, CSF3
2aplastic anemia30.4BRCA2, BRCA1
3chronic lymphocytic leukemia30.0BRCA2, RB1
4acute lymphoblastic leukemia30.0CSF3, PTHLH, RB1
5hodgkin's lymphoma29.9BRCA2, BRCA1, CSF3
6breast cancer29.8BRCA2, BRCA1
7myeloma29.6RB1, BCL2L11, PTHLH, CSF3
8retinoblastoma29.6RB1, BRCA2, BRCA1
9ovarian cancer29.3CSF3, RB1, BRCA1, BRCA2
10burkitt's lymphoma29.3CSF3, BCL2L11, BRCA2, PTHLH, RB1
11prostate cancer29.1BRCA2, PTHLH, BRCA1, RB1, BCL2L11
12leukemia29.0BRCA2, BRCA1, BCL2L11, RB1, CSF3
13hematopoietic stem cell transplantation10.6
14neutropenia10.5
15b-cell lymphomas10.4
16bacteremia10.4
17graft versus host disease10.4
18zygomycosis10.4
19lung cancer10.4CSF3
20hyperuricemia10.3
21fusariosis10.3
22endotheliitis10.3
23breast-ovarian cancer, familial, 110.3BRCA2
24mantle cell lymphoma10.3
25myelodysplastic syndromes10.3
26pulmonary alveolar proteinosis10.3
27candidiasis10.3
28hairy cell leukemia10.3
29diffuse large b-cell lymphoma10.2
30hepatitis10.2
31lymphoblastic lymphoma10.2
32systemic mastocytosis10.2
33strongyloidiasis10.2
34disseminated intravascular coagulation10.2
35eosinophilia10.2
36mediastinitis10.2
37pneumonia10.2
38rhabdomyosarcoma10.2
39sarcoma10.2
40thyroiditis10.2
41acute graft versus host disease10.2
42mastocytosis10.2
43germ cell tumors10.2
44sepsis10.2
45hemoglobin c disease10.2
46central nervous system hematologic cancer10.2
47refractory hematologic cancer10.2
48bone cancer10.2RB1, PTHLH
49acute biphenotypic leukemia10.1
50acute erythroid leukemia10.1

Graphical network of the top 20 diseases related to Hematologic Cancer:



Diseases related to hematologic cancer

Symptoms for Hematologic Cancer

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Drugs & Therapeutics for Hematologic Cancer

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Drug clinical trials:

Search ClinicalTrials for Hematologic Cancer

Search NIH Clinical Center for Hematologic Cancer

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Hematologic Cancer cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Hematologic Cancer:
ALD-151, umbilical cord blood cells for hematologic and immunodefeciency diseases
Allocord, cord blood-derived hematopoietic progenitor cells for hematopoietic reconstitution
Co-infusion of umbilical cord blood and haploidentical CD34+ cells for hematological diseases
Ducord, umbilical cord blood-derived hematopoietic progenitor cells for hematopoietic reconstitution
Expanded cord blood hematopoietic stem cells for hematologic malignancies
Hemacord
Hematopoietic stem cells for treatment of hematologic malignancies
StemEx
Umbilical cord blood-derived hematopoietic progenitor cells for hematopoietic reconstitution
Umbilical cord blood-derived hematopoietic progenitor cells for hematopoietic reconstitution
Embryonic/Adult Cultured Cells Related to Hematologic Cancer:
Umbilical cord blood ALDH+ cells (ALD-151), PMID: 10430905
Umbilical cord blood-derived hematopoietic progenitor cells (Allocord), PMID: 11953027
Peripheral blood-derived hematopoietic stem cells
Umbilical cord blood-derived hematopoietic progenitor cells (Ducord), PMIDs: 22698485, 21810098, 23711284, 21277377
Mesenchymal Precursor Cells (STRO-3 selected), PMID: 21396596
Expanded umbilical cord blood-derived hematopoietic stem cells, PMID: 21396596
Umbilical cord blood-derived hematopoietic progenitor cells (HEMACORD, PMID: 9828244
Bone marrow-derived hematopoietic stem cells
Umbilical cord blood stem/progenitor cells (Stemex), PMID: 18209724
Umbilical cord blood stem/progenitor cells (Stemex), PMID: 18209724
Umbilical cord blood-derived hematopoietic stem cells (family), PMID: 20676147
Umbilical cord blood-derived hematopoietic stem cells (family)

Genetic Tests for Hematologic Cancer

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Genetic tests related to Hematologic Cancer:

id Genetic test Affiliating Genes
1 Hematologic Neoplasm22

Anatomical Context for Hematologic Cancer

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MalaCards organs/tissues related to Hematologic Cancer:

32
Bone, Bone marrow, Lymph node, Testes, Heart, Breast, Myeloid

FMA organs/tissues related to Hematologic Cancer:

14
The hematological system

Animal Models for Hematologic Cancer or affiliated genes

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Publications for Hematologic Cancer

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Articles related to Hematologic Cancer:

(show all 34)
idTitleAuthorsYear
1
The microfluidic multitrap nanophysiometer for hematologic cancer cell characterization reveals temporal sensitivity of the calcein-AM efflux assay. (24873950)
2014
2
Design of a cost-effectiveness analysis alongside a randomized trial of transplantation using umbilical cord blood versus HLA-haploidentical related bone marrow in advanced hematologic cancer. (24645687)
2014
3
Combination of vaccine-strain measles and mumps virus synergistically kills a wide range of human hematological cancer cells: Special focus on acute myeloid leukemia. (25193462)
2014
4
The falling incidence of hematologic cancer after heart transplantation. (25100534)
2014
5
Confirmation of the reported association of clonal chromosomal mosaicism with an increased risk of incident hematologic cancer. (23533652)
2013
6
Internet-based program for coping with cancer: a randomized controlled trial with hematologic cancer patients. (22565413)
2013
7
Xist RNA is a potent suppressor of hematologic cancer in mice. (23415223)
2013
8
Evaluation of MycAssaya8c Aspergillus for diagnosis of invasive pulmonary aspergillosis in patients without hematological cancer. (23620764)
2013
9
Thymidylate synthase polymorphisms and hematological cancer risk: a meta-analysis. (22166040)
2012
10
Family history of non-hematologic cancers among Waldenstrom macroglobulinemia patients: a preliminary study. (22099500)
2012
11
A stapled BIM peptide overcomes apoptotic resistance in hematologic cancers. (22622039)
2012
12
p53 codon 72 polymorphism and hematological cancer risk: an update meta-analysis. (23029260)
2012
13
Improving access to information and support for patients with less common cancers: hematologic cancer patients' views about Web-based approaches. (22189354)
2011
14
Physical activity and hematologic cancer prevention. (21113763)
2011
15
Evolving information priorities of hematologic cancer survivors, caregivers, and other relatives. (20119694)
2010
16
Mesial temporal sclerosis as a complication of hematologic cancer. (19434437)
2009
17
Managed care considerations: hematologic cancer as a chronic disease. (19119536)
2008
18
Phase 3 trials suggest ways to improve current hematologic cancer therapies. (18252877)
2008
19
Femoral resurfacing in young patients with hematologic cancer and osteonecrosis. (18679763)
2008
20
Searching for evidence of disease and malignant cell contamination in ovarian tissue stored from hematologic cancer patients. (18344563)
2008
21
Posaconazole prophylaxis in hematologic cancer. (17526090)
2007
22
Posaconazole prophylaxis in hematologic cancer. (17526089)
2007
23
The BRCA1/2 pathway prevents hematologic cancers in addition to breast and ovarian cancers. (17683622)
2007
24
Posaconazole prophylaxis in hematologic cancer. (17522407)
2007
25
Posaconazole prophylaxis in hematologic cancer. (17526091)
2007
26
Serum Aspergillus galactomannan antigen values strongly correlate with outcome of invasive aspergillosis: a study of 56 patients with hematologic cancer. (17607669)
2007
27
Low mannose-binding lectin concentration is associated with severe infection in patients with hematological cancer who are undergoing chemotherapy. (17516403)
2007
28
Patient-rated emotional and physical functioning among hematologic cancer patients during hospitalization for stem-cell transplantation. (15580279)
2005
29
In vitro chemosensitivity testing of hematological cancer patients: detection of ornithine decarboxylase. (12528799)
2003
30
Psychiatric morbidity and impact on hospital length of stay among hematologic cancer patients receiving stem-cell transplantation. (11919251)
2002
31
In vitro chemosensitivity testing of hematological cancers: immunohistochemical detection of ornithine decarboxylase. (10587289)
1999
32
Phase I trial of a 90-minute infusion of the fusion toxin DAB486IL-2 in hematological cancers. (8358720)
1993
33
Autologous bone marrow transplantation for hematologic cancer. (2236163)
1990
34
Alzheimer's disease and senile dementia: genetic relationships to Down's syndrome and hematologic cancer. (154163)
1979

Variations for Hematologic Cancer

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Expression for genes affiliated with Hematologic Cancer

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Expression patterns in normal tissues for genes affiliated with Hematologic Cancer

Search GEO for disease gene expression data for Hematologic Cancer.

Pathways for genes affiliated with Hematologic Cancer

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Pathways related to Hematologic Cancer according to GeneCards/GeneDecks:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
FAS pathway and Stress induction of HSP regulation37
Apoptosis and survival FAS signaling cascades60
Caspase cascade in apoptosis37
9.5RB1, BCL2L11
29.4BRCA2, RB1
3
Show member pathways
9.4RB1, BRCA2
49.2RB1, BRCA1
59.2BRCA1, RB1
6
Show member pathways
9.2RB1, BRCA1
7
Show member pathways
DNA damage response37
9.2RB1, BRCA1
8
Show member pathways
Prostate Cancer37
Integrated Cancer pathway37
Steroid Biosynthesis37
9.2BRCA1, RB1
9
Show member pathways
9.0BRCA1, BRCA2
10
Show member pathways
9.0BRCA1, BRCA2
119.0BRCA1, BRCA2
129.0BRCA1, BRCA2
13
Show member pathways
9.0BRCA2, BRCA1
14
Show member pathways
9.0BRCA1, BRCA2
15
Show member pathways
9.0BRCA1, BRCA2
168.6CSF3, BCL2L11, BRCA1
17
Show member pathways
Signaling Pathways in Glioblastoma37
8.6RB1, BRCA1, BRCA2
18
Show member pathways
8.6RB1, BRCA1, BRCA2
198.6RB1, BRCA1, BRCA2
20
Show member pathways
8.6BRCA2, BRCA1, RB1
21
Show member pathways
8.6BRCA2, BRCA1, RB1
22
Show member pathways
8.2BRCA1, BCL2L11, CSF3, RB1

Compounds for genes affiliated with Hematologic Cancer

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Compounds related to Hematologic Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 73)
idCompoundScoreTop Affiliating Genes
1gossypol449.8BCL2L11, RB1
2teniposide44 1110.8RB1, CSF3
3vinorelbine44 50 1111.3CSF3, BRCA1
48-oxoguanine449.3BRCA1, BRCA2
5aphidicolin449.3RB1, BRCA1
6daidzein449.3BRCA1, BRCA2
7matrigel449.2BRCA2, RB1, PTHLH
8lycopene44 2410.2BRCA1, BRCA2
9agar449.1RB1, PTHLH, BRCA1
10actinomycin d449.1RB1, PTHLH, BCL2L11
11carboplatin44 50 1111.1RB1, CSF3, BRCA1
12platinum44 5010.0CSF3, BRCA1
13indole-3-carbinol449.0BRCA2, BRCA1
145fluorouracil449.0RB1, CSF3, BRCA1
15adpribose449.0RB1, BRCA2, BRCA1
16p003449.0BRCA1, BRCA2, RB1
17p002449.0RB1, BRCA1, BRCA2
18resveratrol44 61 24 1112.0BRCA1, RB1, BRCA2
19camptothecin44 61 1110.9RB1, BRCA1, BRCA2
20hydroxyurea44 50 1110.9BRCA2, BRCA1, CSF3
21dexamethasone44 50 28 1111.9RB1, PTHLH, BCL2L11, CSF3
22polyacrylamide448.9BRCA2, BRCA1, RB1
23docetaxel44 50 61 1111.9BRCA1, CSF3, BRCA2
24tamoxifen44 50 28 1111.8PTHLH, BRCA2, BRCA1
25doxorubicin44 50 1110.8BRCA1, CSF3, RB1
26cyclophosphamide44 50 1110.7BRCA1, CSF3, PTHLH, RB1
27vegf448.6RB1, PTHLH, BRCA1, CSF3
28estradiol44 24 1110.6PTHLH, BRCA2, BRCA1, RB1
29paraffin448.6BRCA2, BRCA1, PTHLH, RB1
30progesterone44 28 61 24 1112.6BRCA1, PTHLH, BRCA2, RB1
31bleomycin44 119.5BRCA2, BRCA1, CSF3, PTHLH
32oxygen44 249.5BCL2L11, RB1, BRCA1, PTHLH
33testosterone44 61 24 1111.5BRCA1, BRCA2, PTHLH, RB1
34steroid448.5PTHLH, BRCA2, BRCA1, RB1
35mitomycin c448.5CSF3, BRCA2, RB1, BRCA1
36adriamycin448.5BRCA2, BRCA1, CSF3, RB1
37methotrexate50 44 1110.5BRCA1, RB1, CSF3, BRCA2
38h2o2448.4BRCA1, BRCA2, BCL2L11, RB1
39oligonucleotide448.4BRCA2, RB1, BRCA1, BCL2L11
40genistein44 28 61 2 24 1113.3BRCA2, BRCA1, RB1
41tyrosine448.1CSF3, BCL2L11, BRCA1, PTHLH, RB1
42vincristine44 50 1110.1PTHLH, RB1, BRCA2, BRCA1, CSF3
43thymidine44 249.1RB1, BRCA1, BRCA2, PTHLH, CSF3
44cisplatin44 50 61 1111.1BRCA2, CSF3, PTHLH, BRCA1, RB1
45phosphatidylinositol448.1BRCA1, PTHLH, BRCA2, BCL2L11, RB1
46estrogen448.1PTHLH, RB1, BRCA1, BRCA2, BCL2L11
47retinoic acid44 249.1BRCA1, RB1, CSF3, BRCA2, PTHLH
48cycloheximide448.0BRCA2, PTHLH, BCL2L11, CSF3, BRCA1
49etoposide44 50 61 1111.0BRCA2, CSF3, RB1, BCL2L11, BRCA1
50paclitaxel44 50 119.6BRCA1, RB1, CSF3, BCL2L11, BRCA2, PTHLH

GO Terms for genes affiliated with Hematologic Cancer

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Biological processes related to Hematologic Cancer according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of sequence-specific DNA binding transcription factor activityGO:0434339.7RB1, PTHLH
2androgen receptor signaling pathwayGO:0305219.3RB1, BRCA1
3intrinsic apoptotic signaling pathway in response to DNA damageGO:0086309.2BCL2L11, BRCA1
4DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.2BRCA1, BRCA2
5double-strand break repair via homologous recombinationGO:0007248.9BRCA1, BRCA2
6double-strand break repairGO:0063028.7BRCA1, BRCA2
7positive regulation of transcription from RNA polymerase II promoterGO:0459448.7RB1, CSF3, BRCA1
8positive regulation of transcription, DNA-templatedGO:0458938.6BRCA2, BRCA1, RB1

Molecular functions related to Hematologic Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1androgen receptor bindingGO:0506819.2RB1, BRCA1

Products for genes affiliated with Hematologic Cancer

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  • Antibodies
  • Proteins
  • Lysates

Sources for Hematologic Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet