MCID: HMT018
MIFTS: 58

Hematopoietic Stem Cell Transplantation

Categories: Blood diseases, Rare diseases

Aliases & Classifications for Hematopoietic Stem Cell Transplantation

MalaCards integrated aliases for Hematopoietic Stem Cell Transplantation:

Name: Hematopoietic Stem Cell Transplantation 37 55

Characteristics:

Orphanet epidemiological data:

55
hematopoietic stem cell transplantation
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe);

Classifications:



External Ids:

Orphanet 55 ORPHA90053
ICD10 via Orphanet 33 Z94.8

Summaries for Hematopoietic Stem Cell Transplantation

MalaCards based summary : Hematopoietic Stem Cell Transplantation is related to aspergillosis and chronic active epstein-barr virus infection. An important gene associated with Hematopoietic Stem Cell Transplantation is ARHGAP45 (Rho GTPase Activating Protein 45), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. The drugs Micafungin and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include t cells, myeloid and bone, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 72 Hematopoietic stem cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem... more...

Related Diseases for Hematopoietic Stem Cell Transplantation

Diseases related to Hematopoietic Stem Cell Transplantation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 597)
# Related Disease Score Top Affiliating Genes
1 aspergillosis 32.6 CLEC7A IFNG IL10
2 chronic active epstein-barr virus infection 31.5 CTLA4 IFNG IL10 IL2
3 bronchiolitis obliterans 30.7 IFNG IL10 IL6 TNF
4 bronchiolitis 30.7 IFNG IL10 IL6 TNF
5 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 30.7 CTLA4 IFNG IL10
6 cytomegalovirus retinitis 30.6 HLA-B IFNG TNF
7 hemophagocytic lymphohistiocytosis 30.6 IFNG IL10 TNF
8 pneumonia 30.5 IL10 IL6 TNF
9 post-transplant lymphoproliferative disease 30.4 IL10 IL6 TNF
10 acute graft versus host disease 30.4 ARHGAP45 IFNG IL10 IL2 TNF
11 omenn syndrome 30.2 IFNG IL10 TNF
12 pure red-cell aplasia 30.2 HLA-A HLA-B IL2
13 candidiasis 30.2 CLEC7A IFNG IL10
14 mycobacterium tuberculosis 1 30.1 IFNG IL10 TNF
15 demyelinating disease 30.1 IFNG IL10 TNF
16 trichosporonosis 30.1 IFNG TNF
17 cytomegalovirus infection 30.1 IFNG IL10 IL6 KIR3DL1 TNF
18 severe cutaneous adverse reaction 30.0 HLA-A HLA-B HLA-C
19 monocytic leukemia 29.9 IFNG IL6 TNF
20 leishmaniasis 29.9 IFNG IL10 TNF
21 viral encephalitis 29.8 IL10 IL6 TNF
22 meningitis 29.8 IFNG IL10 IL6 TNF
23 nervous system disease 29.8 IFNG IL10 IL6 TNF
24 bacterial meningitis 29.8 IL10 IL6 TNF
25 myocarditis 29.8 HLA-B IL6 TNF
26 central nervous system vasculitis 29.8 IFNG IL6 TNF
27 rheumatic disease 29.7 HLA-B IFNG IL10 TNF
28 multicentric castleman disease 29.7 IFNG IL10 IL6
29 toxoplasmosis 29.7 IFNG IL10 IL6 TNF
30 relapsing-remitting multiple sclerosis 29.7 IFNG IL10 IL6 TNF
31 thyroiditis 29.7 CTLA4 IFNG IL2
32 periodontitis 29.5 IFNG IL10 IL6 TNF
33 interstitial lung disease 29.4 IFNG IL10 IL6 TNF
34 crohn's disease 29.4 IFNG IL10 IL6 TNF
35 erythema multiforme 29.4 IFNG IL2 TNF
36 aplastic anemia 29.4 HLA-A HLA-B IFNG IL2 IL6 TNF
37 arthritis 29.3 IFNG IL10 IL6 TNF
38 conjunctivitis 29.3 IFNG IL2 IL6
39 sezary's disease 29.3 CTLA4 IFNG IL2 KIR3DL1
40 tetanus 29.3 IFNG IL10 IL2
41 herpes zoster 29.2 HLA-A IFNG IL10 IL2
42 visceral leishmaniasis 29.1 IFNG IL10 IL2 TNF
43 graft-versus-host disease 29.0 ARHGAP45 HLA-A HLA-B HLA-C IFNG IL10
44 colitis 29.0 IFNG IL10 IL2 IL6 TNF
45 hashimoto thyroiditis 29.0 CTLA4 IFNG IL2
46 multiple sclerosis 28.9 CTLA4 IFNG IL10 IL2 IL6 TNF
47 immune suppression 28.9 IFNG IL10 IL2 IL6
48 myasthenia gravis 28.6 CTLA4 IFNG IL10 IL2 TNF
49 ulcerative colitis 28.6 IFNG IL10 IL2 IL6 TNF
50 systemic lupus erythematosus 28.3 CTLA4 IFNG IL10 IL2 IL6 TNF

Graphical network of the top 20 diseases related to Hematopoietic Stem Cell Transplantation:



Diseases related to Hematopoietic Stem Cell Transplantation

Symptoms & Phenotypes for Hematopoietic Stem Cell Transplantation

GenomeRNAi Phenotypes related to Hematopoietic Stem Cell Transplantation according to GeneCards Suite gene sharing:

25 (show all 34)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-101 10.28 CLEC7A
2 Increased shRNA abundance (Z-score > 2) GR00366-A-103 10.28 HLA-B HLA-A CLEC7A HLA-C
3 Increased shRNA abundance (Z-score > 2) GR00366-A-107 10.28 CLEC7A
4 Increased shRNA abundance (Z-score > 2) GR00366-A-110 10.28 HLA-A HLA-B HLA-C
5 Increased shRNA abundance (Z-score > 2) GR00366-A-115 10.28 HLA-E
6 Increased shRNA abundance (Z-score > 2) GR00366-A-118 10.28 HLA-B HLA-A HLA-C
7 Increased shRNA abundance (Z-score > 2) GR00366-A-12 10.28 CLEC7A
8 Increased shRNA abundance (Z-score > 2) GR00366-A-124 10.28 HLA-C
9 Increased shRNA abundance (Z-score > 2) GR00366-A-128 10.28 CLEC7A
10 Increased shRNA abundance (Z-score > 2) GR00366-A-135 10.28 CLEC7A
11 Increased shRNA abundance (Z-score > 2) GR00366-A-143 10.28 CLEC7A
12 Increased shRNA abundance (Z-score > 2) GR00366-A-147 10.28 CLEC7A
13 Increased shRNA abundance (Z-score > 2) GR00366-A-149 10.28 CLEC7A HLA-E HLA-C
14 Increased shRNA abundance (Z-score > 2) GR00366-A-156 10.28 HLA-B HLA-A HLA-C
15 Increased shRNA abundance (Z-score > 2) GR00366-A-158 10.28 CLEC7A
16 Increased shRNA abundance (Z-score > 2) GR00366-A-162 10.28 HLA-C
17 Increased shRNA abundance (Z-score > 2) GR00366-A-164 10.28 CLEC7A
18 Increased shRNA abundance (Z-score > 2) GR00366-A-168 10.28 HLA-E
19 Increased shRNA abundance (Z-score > 2) GR00366-A-178 10.28 HLA-A HLA-B HLA-C
20 Increased shRNA abundance (Z-score > 2) GR00366-A-186 10.28 CLEC7A HLA-E
21 Increased shRNA abundance (Z-score > 2) GR00366-A-19 10.28 HLA-B HLA-A HLA-C
22 Increased shRNA abundance (Z-score > 2) GR00366-A-202 10.28 CLEC7A HLA-C
23 Increased shRNA abundance (Z-score > 2) GR00366-A-205 10.28 CLEC7A
24 Increased shRNA abundance (Z-score > 2) GR00366-A-214 10.28 CLEC7A
25 Increased shRNA abundance (Z-score > 2) GR00366-A-29 10.28 CLEC7A
26 Increased shRNA abundance (Z-score > 2) GR00366-A-30 10.28 CLEC7A
27 Increased shRNA abundance (Z-score > 2) GR00366-A-31 10.28 HLA-A HLA-B HLA-E HLA-C
28 Increased shRNA abundance (Z-score > 2) GR00366-A-47 10.28 HLA-C
29 Increased shRNA abundance (Z-score > 2) GR00366-A-57 10.28 CLEC7A
30 Increased shRNA abundance (Z-score > 2) GR00366-A-7 10.28 HLA-B HLA-A HLA-C
31 Increased shRNA abundance (Z-score > 2) GR00366-A-74 10.28 HLA-B HLA-A HLA-C
32 Increased shRNA abundance (Z-score > 2) GR00366-A-79 10.28 CLEC7A
33 Increased shRNA abundance (Z-score > 2) GR00366-A-9 10.28 CLEC7A
34 Increased shRNA abundance (Z-score > 2) GR00366-A-93 10.28 HLA-C

MGI Mouse Phenotypes related to Hematopoietic Stem Cell Transplantation:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.5 CLEC7A CTLA4 IFNG IL10 IL2 IL6
2 respiratory system MP:0005388 9.17 CLEC7A CTLA4 IFNG IL10 IL2 IL6

Drugs & Therapeutics for Hematopoietic Stem Cell Transplantation

Drugs for Hematopoietic Stem Cell Transplantation (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 586)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Micafungin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 235114-32-6 477468 3081921
2
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 22916-47-8 4189
3
Azacitidine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 320-67-2 9444
4
Decitabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 2353-33-5 451668
5
Cyclophosphamide Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 50-18-0, 6055-19-2 2907
6
Etoposide Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 33419-42-0 36462
7
Teniposide Approved Phase 4,Phase 2 29767-20-2 34698
8
Nystatin Approved, Vet_approved Phase 4,Phase 3 1400-61-9 11953884
9
Idarubicin Approved Phase 4,Phase 3,Phase 2,Phase 1 58957-92-9 42890
10
Iron Approved Phase 4,Phase 2,Phase 3 7439-89-6 23925
11
Methotrexate Approved Phase 4,Phase 2,Phase 3,Phase 1 1959-05-2, 59-05-2 126941
12
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 104987-11-3 445643 439492
13
Busulfan Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 55-98-1 2478
14
Cytarabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 147-94-4 6253
15
Lomustine Approved, Investigational Phase 4 13010-47-4 3950
16
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 128794-94-5 5281078
17
Mycophenolic acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 24280-93-1 446541
18
Fludarabine Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 21679-14-1, 75607-67-9 30751
19
Vidarabine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 24356-66-9 21704 32326
20
Posaconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1 171228-49-2 147912
21
Voriconazole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 137234-62-9 71616
22
Basiliximab Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 179045-86-4, 152923-56-3
23
Foscarnet Approved Phase 4,Phase 3,Phase 2 4428-95-9, 63585-09-1 3415
24
Ganciclovir Approved, Investigational Phase 4,Phase 3,Phase 2 82410-32-0 3454
25
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-02-2 5743
26
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 53-03-2 5865
27
Deferasirox Approved, Investigational Phase 4,Phase 2 201530-41-8 5493381
28
Itraconazole Approved, Investigational Phase 4,Phase 3,Phase 2 84625-61-6 55283
29
Protein C Approved Phase 4
30
Menthol Approved Phase 4,Phase 2,Phase 1 2216-51-5 16666
31
Hydroxocobalamin Approved Phase 4 13422-51-0 5460373 44475014 11953898
32
Ledipasvir Approved Phase 4 1256388-51-8 67505836
33
Sofosbuvir Approved Phase 4 1190307-88-0 45375808
34
Peginterferon alfa-2b Approved Phase 4 215647-85-1, 99210-65-8
35
Aprepitant Approved, Investigational Phase 4 170729-80-3 6918365 151165
36
Fosaprepitant Approved Phase 4 172673-20-0 219090
37
Tropisetron Approved, Investigational Phase 4 105826-92-4, 89565-68-4 5595
38
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 59-30-3 6037
39
leucovorin Approved, Nutraceutical Phase 4,Phase 2,Phase 3,Phase 1 58-05-9 143 6006
40
Cholecalciferol Approved, Nutraceutical Phase 4,Phase 2 67-97-0 10883523 5280795 6221
41
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 1,Phase 2 50-14-6 5280793
42
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 1,Phase 2 1406-16-2
43
Cyanocobalamin Approved, Nutraceutical Phase 4 68-19-9 44176380
44
Methylcobalamin Approved, Experimental, Investigational, Nutraceutical Phase 4 13422-55-4
45
Phosphonoacetic Acid Experimental Phase 4,Phase 3,Phase 2 4408-78-0 546
46
Treosulfan Investigational Phase 4,Phase 3,Phase 2,Phase 1 299-75-2 9296
47
Substance P Investigational Phase 4 33507-63-0 44359816
48 Antifungal Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
49 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
50 Echinocandins Phase 4,Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 1691)

# Name Status NCT ID Phase Drugs
1 Micafungin Prevention Study for Fungal Disease in Child Receiving Allogenic Hematopoietic Stem Cell Transplantation Unknown status NCT01135589 Phase 4 Micafungin
2 Efficacy and Safety of rHuTPO on Platelet Engraftment After Allo-HSCT Unknown status NCT01379391 Phase 4 Recombinant Human Thrombopoietin (rHTPO)
3 Decitabine for Myelodysplastic Syndromes and Acute Myeloid Leukemia Before Allogeneic Hematopoietic Cell Transplantation Unknown status NCT01806116 Phase 4 decitabine
4 ATG Could Improve the Outcome Of Hematopoietic Stem Cell Transplant in Patients With Highly Aggressive T Cell Tumors Unknown status NCT02290132 Phase 4 Rabbit Anti-human Thymocyte Globulin (ATG)
5 Oral Hygiene Regimen in Patients on HCT Unknown status NCT02662374 Phase 4 .02% Chlorohexidine Gluconate;3% Sodium Bicarbonate;Nystatin 10000U/ml;Supersaturated Calcium Phosphate
6 HD-Idarubicin/Etoposide Intensified Conditioning Regimen Allo-HSCT for Adult ALL Unknown status NCT01873807 Phase 4 IDA;CTX;VP-16
7 Post Hematopoietic Stem Cell Transplantation Completed NCT01610297 Phase 4 ICL670
8 Study to Assess the Safety and Efficacy of Tacrolimus (Prograf Capsule/Injection) and Methotrexate (MTX) Combination Therapy for Prevention of Graft Versus Host Disease (GVHD) in Patients Who Received Peripheral Hematopoietic Stem Cell Transplantation Fro Completed NCT02660684 Phase 4 Prograf;Methotrexate;Cyclosporine
9 Efficacy of Prophylactic Itraconazole in High-Dose Chemotherapy and Autologous Hematopoietic Stem Cell Transplantation Completed NCT00336531 Phase 4 itraconazole
10 ATG in Haploidentical HSCT for Acute Graft-versus-host Disease Prophylaxis Completed NCT01883180 Phase 4 ATG
11 Open-Label Single-Arm Pilot Study in Adult Allogeneic Hematopoietic Stem Cell Transplant Recipients With Transfusional Iron Overload Completed NCT01335035 Phase 4 deferasirox
12 Glutamine Popsicles in Bone Marrow Transplant (BMT)/Hematopoietic Stem Cell Transplant (HSCT) Patients Completed NCT00204958 Phase 4 nutritional supplement;glutamine popsicle
13 Efficacy and Safety of Oral Deferasirox (20 mg/kg/d) in Pts 3 to 6 Months After Allogeneic Hematopoietic Cell Transplantation Who Present With Iron Overload Completed NCT00654589 Phase 4 Deferasirox
14 Bronchodilator Responsiveness in Obliterative Bronchiolitis Completed NCT01112241 Phase 4 albuterol plus tiotropium
15 Busulfan Safety/Efficacy as Conditioning Prior to Hematopoietic Cell Transplantation (HCT) Completed NCT00361140 Phase 4 Busulfan;Fludarabine
16 A Safety Evaluation of Drotrecogin Alfa (Activated) in Patients With Blood Cancer, Severe Infection Related to Bone Marrow Transplantation Completed NCT00067730 Phase 4 Drotrecogin Alfa (activated)
17 Adjuvanted Influenza Vaccine in Stem Cell Transplant Completed NCT02560909 Phase 4
18 A New Dosing Regimen for Posaconazole Prophylaxis in Children Based on Body Surface Area Completed NCT02372357 Phase 4 Posaconazole prophylaxis 120 mg/m² tid
19 A Trial Comparing Efficacy and Safety of Voriconazole Administered With Therapeutic Drug Monitoring vs. Standard Dosing Completed NCT01416025 Phase 4 Prospective TDM Arm
20 Erythropoietin in the Treatment of Anemia After Autologous Hematopoietic Stem Cell Transplantation Recruiting NCT03010579 Phase 4 erythropoietin;iron supplementation
21 Haploidentical Hematopoietic Stem Cell Transplantation for Patients With Thalassemia Major Recruiting NCT03171831 Phase 4 Busulfan;Cyclophosphamide;Fludarabine;Mycophenolate mofetil;Tacrolimus;Methotrexate;Thymoglobulin;Basiliximab
22 Efficacy of Basiliximab in the Prevention of Acute Graft-versus-host Disease in Unrelated Allogeneic Hematopoietic Stem Cell Transplantation Therapy for Thalassemia Major Recruiting NCT02342145 Phase 4 Basiliximab,;cyclosporine A;Methotrexate;Mycophenolate mofetil
23 Ledipasvir/Sofosbuvir Treatment for Hepatitis C in HCT Recipients. Recruiting NCT03279133 Phase 4 Ledipasvir 90mg/Sofosubvir 400mg
24 CMV-CTL for the Treatment of CMV Infection After HSCT Recruiting NCT03004261 Phase 4 Foscarnet;Ganciclovir
25 PEG-rhG-CSF in Lymphoma Patients After Autologous Hematopoietic Stem Cell Transplantation Recruiting NCT02905942 Phase 4 PEG-rhG-CSF;rhG-CSF
26 Post-transplantation Cyclophosphamide for Haploidentical Transplant From Maternal or Collateral Donors Recruiting NCT02412423 Phase 4 post-transplantation cyclophosphamide
27 Study of Standard and Individualized Treatment Model for Relapse and Refractory Lymphatic System Malignant Tumors Recruiting NCT02929615 Phase 4
28 Early Tapering of Immunosuppressive Agents to Immunomodulation to Improve Survival of AML Patients Recruiting NCT03150134 Phase 4 Cyclosporine;routine reduction of immunosuppressive drugs(cyclosporine)
29 Peg Interferon α-2b for Relapsed Hematological Malignancies After Allo-HSCT Recruiting NCT02634294 Phase 4 Peg interferon alfa-2b
30 ALL SCTped FORUM - Pharmacogenomic Study (add-on Study) Recruiting NCT02670564 Phase 4
31 ATG Based Conditioning Regimen in HLA Related HSCT for Aggressive T-cell Tumors Recruiting NCT02938741 Phase 4 Anti-human Thymoglobulin;Placebo
32 Chemotherapy and Imatinib in Young Adults With Acute Lymphoblastic Leukemia Ph (BCR-ABL) POSITIVE Recruiting NCT01491763 Phase 4 Imatinib
33 A Pralatrexate Study in Asian Patients With Peripheral T-cell Lymphoma After Prior Therapy Recruiting NCT03150602 Phase 4 Pralatrexate
34 A Study Evaluating the Efficacy and Safety of Aprepitant in Autologous Hematopoietic Stem Cell Transplantation Active, not recruiting NCT02576327 Phase 4 Tropisetron;Dexamethasone;Aprepitant
35 A Optimal Anti-Thymoglobuline (ATG) Dose Decrease cGVHD But Not Increase Leukemia Relapse for Haplo-HSCT Not yet recruiting NCT03190733 Phase 4 ATG
36 A Randomized Phase IV Control Trial of Single High Dose Oral Vitamin D3 in Pediatric Patients Undergoing HSCT Not yet recruiting NCT03176849 Phase 4
37 Evaluation of Antifungal Prophylaxis on Graft-versus-host Disease (GVHD) Patients Terminated NCT01282879 Phase 4 Itraconazole
38 Hematopoietic Stem Cell Transplantation for Mucopolysaccharidosis Unknown status NCT01238328 Phase 2, Phase 3 Conditioning regimen;Graft-versus-host disease (GVHD) prophylaxis
39 Hematopoietic Stem Cell Transplantation for Malignant Infantile Osteopetrosis Unknown status NCT01087398 Phase 2, Phase 3 Busulfan, Cyclophosphamide, Thymoglobulin, Fludarabine (Conditioning regimen);Cyclosporin, Methotrexate (GVHD prophylaxis)
40 Palifermin for Patients Receiving Hematopoietic Stem Cell Transplantation Unknown status NCT02313792 Phase 3 Palifermin
41 Hematopoietic Stem Cell Transplantation in Myeloma Unknown status NCT00415987 Phase 2, Phase 3
42 Evaluation of Plasmatic Levels of Busulfan in Patients Undergoing Hematopoietic Stem Cell Transplantation Unknown status NCT01800643 Phase 2, Phase 3
43 Allogeneic Transplantation For Severe Osteopetrosis Unknown status NCT00775931 Phase 2, Phase 3 Campath-1H;Cyclophosphamide;Busulfan;Fludarabine monophosphate
44 Lactobacillus Brevis CD2 Preventing Oral Mucositis Unknown status NCT02085694 Phase 2, Phase 3 Lactobacillus brevis CD2
45 The Effect of Folinic Acid Rescue Following MTX GVHD Prophylaxis on Regimen Related Toxicity and Transplantation Outcome Unknown status NCT02506231 Phase 2, Phase 3 Folinic acid;Placebo
46 Comparison of Cy-Atg vs Flu-Atg for the Conditioning Therapy in Allo-HCT for Adult Aplastic Anemia Unknown status NCT01145976 Phase 3 Cy-ATG;Flu-ATG
47 Prospective Study of Patients With Thrombocytopenia Following HSCT Unknown status NCT02487563 Phase 3 decitabine;rhTPO
48 Hemofiltration for Respiratory Failure After Bone Marrow Transplantation Unknown status NCT00120575 Phase 2, Phase 3
49 Interferon Alfa-2b Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Recurrent or Refractory Hodgkin's Disease or Non-Hodgkin's Lymphoma Unknown status NCT00003924 Phase 3
50 High-Dose Melphalan and a Second Stem Cell Transplant or Low-Dose Cyclophosphamide in Treating Patients With Relapsed Multiple Myeloma After Chemotherapy Unknown status NCT00747877 Phase 3 cyclophosphamide;melphalan

Search NIH Clinical Center for Hematopoietic Stem Cell Transplantation

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Stem-cell-based therapeutic approaches for Hematopoietic Stem Cell Transplantation:
ATIR
Bone marrow-derived mesenchymal stem cells combined with cord blood for treatment of graft failure
Bone marrow-derived mesenchymal stem cells for treatment of poor graft function
Embryonic/Adult Cultured Cells Related to Hematopoietic Stem Cell Transplantation:
ATIR PMIDs: 17977031 17878399 23206844 20798236 12091325
Bone marrow-derived mesenchymal stem cells

Genetic Tests for Hematopoietic Stem Cell Transplantation

Anatomical Context for Hematopoietic Stem Cell Transplantation

MalaCards organs/tissues related to Hematopoietic Stem Cell Transplantation:

38
T Cells, Myeloid, Bone, Bone Marrow, B Cells, Kidney, Lung

Publications for Hematopoietic Stem Cell Transplantation

Articles related to Hematopoietic Stem Cell Transplantation:

(show top 50) (show all 1831)
# Title Authors Year
1
Poor outcome with hematopoietic stem cell transplantation for bone marrow failure and MDS with severe MIRAGE syndrome phenotype. ( 29365320 )
2018
2
Chronic disseminated candidiasis and acute leukemia: Impact on survival and hematopoietic stem cell transplantation agenda. ( 29307444 )
2018
3
Outcomes of Children with Hemophagocytic Lymphohistiocytosis Given Allogeneic Hematopoietic Stem Cell Transplantation in Italy. ( 29410181 )
2018
4
Allogeneic Hematopoietic Stem-Cell Transplantation for GATA2 Deficiency Using a Busulfan-Based Regimen. ( 29412158 )
2018
5
Characterization of innate immune viral sensors in patients following allogeneic hematopoietic stem cell transplantation. ( 29433372 )
2018
6
Successful treatment of refractory autoimmune hemolytic anemia after allogeneic hematopoietic stem cell transplantation with bortezomib. ( 29345206 )
2018
7
A Controlled Trial of Sheng-Yu-Tang for Post-Hematopoietic Stem Cell Transplantation Leukemia Patients: A Proposed Protocol and Insights From a Preliminary Pilot Study. ( 29431027 )
2018
8
Treatment of High-Risk Acute Myeloid Leukemia With Cladribine, Cytarabine, Mitoxantrone, and Granulocyte Colony-Stimulating Factor Then Subsequent Bridging to Myeloablative Allogeneic Hematopoietic Stem Cell Transplantation: A Case Series. ( 29407318 )
2018
9
Allogeneic hematopoietic stem cell transplantation for relapsed follicular lymphoma: A combined analysis on behalf of the Lymphoma Working Party of the EBMT and the Lymphoma Committee of the CIBMTR. ( 29424927 )
2018
10
Allogeneic hematopoietic stem cell transplantation for relapsed acute myeloid leukemia in ETO positive with reduced-intensity conditioning. ( 29416633 )
2018
11
Single Antigen-Mismatched Unrelated Hematopoietic Stem Cell Transplantation Using High-Dose Post-Transplantation Cyclophosphamide Is a Suitable Alternative for Patients Lacking HLA-Matched Donors. ( 29410343 )
2018
12
Successful treatment of pure red cell aplasia with high-dose dexamethasone after ABO-incompatible allogeneic hematopoietic stem cell transplantation. ( 29079126 )
2018
13
Association analysis between SUFU polymorphism rs17114808 and acute graft versus host disease after hematopoietic stem cell transplantation. ( 29330404 )
2018
14
Efficacy of high-dose steroids for bronchiolitis obliterans syndrome post pediatric hematopoietic stem cell transplantation. ( 29417689 )
2018
15
Visual perceptual skills and visual motor integration in children and adolescents after allogeneic hematopoietic stem cell transplantation. ( 29417695 )
2018
16
Mycobacterium abscessus and massiliense lung infection during macrolide treatment for bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation. ( 28988958 )
2018
17
CD1d is a novel cell-surface marker for human monocytic myeloid-derived suppressor cells with T cell suppression activity in peripheral blood after allogeneic hematopoietic stem cell transplantation. ( 29108995 )
2018
18
Outcomes of patients with relapsed aggressive adult T-cell leukemia-lymphoma: clinical effectiveness of anti-CCR4 antibody and allogeneic hematopoietic stem cell transplantation. ( 29371324 )
2018
19
Advantages of non-cryopreserved autologous hematopoietic stem cell transplantation against a cryopreserved strategy. ( 29440738 )
2018
20
Role of up-front allogeneic hematopoietic stem cell transplantation for patients with aggressive adult T-cell leukemia-lymphoma: a decision analysis. ( 29371687 )
2018
21
Possible involvement of IL-6-producing tissue-resident macrophages in early-onset pericardial effusion pathogenesis after hematopoietic stem cell transplantation. ( 29384263 )
2018
22
Cardiovascular risk factors and subclinical organ damage after hematopoietic stem cell transplantation in pediatric age. ( 29426831 )
2018
23
Syngeneic hematopoietic stem cell transplantation from HTLV-1 seropositive twin for adult T-cell leukemia-lymphoma. ( 29358601 )
2018
24
Allogeneic hematopoietic stem cell transplant overcomes the adverse survival effect of very high risk and unfavorable karyotype in myelofibrosis. ( 29388258 )
2018
25
Intravesicular cidofovir for BK hemorrhagic cystitis in pediatric patients after hematopoietic stem cell transplant. ( 29388318 )
2018
26
Kaposi Sarcoma After Allogeneic Hematopoietic Stem Cell Transplant: A Rare Complication. ( 29292681 )
2018
27
HLA-Matched Sibling Vs. Unrelated Vs. Haploidentical Related Donor Allogeneic Hematopoietic Stem Cell Transplantation for Patients Aged Over 60 Years with Acute Myeloid Leukemia: a Single-Center Donor Comparison. ( 29448057 )
2018
28
Hematopoietic stem cell transplantation in Niemann-Pick disease type B monitored by chitotriosidase activity. ( 29090525 )
2018
29
Salvaged allogeneic hematopoietic stem cell transplantation for pediatric chemotherapy refractory acute leukemia. ( 29423036 )
2018
30
Donor Cell-Derived Hematological Neoplasms after Hematopoietic Stem Cell Transplantation. a Systematic Review. ( 29410295 )
2018
31
Allogeneic hematopoietic stem cell transplantation in Primary Cutaneous T Cell Lymphoma. ( 29442161 )
2018
32
Gallbladder wall oedema and ascites are independent predictors of progression to hepatic veno-occlusive disease for children with hematopoietic stem cell transplantation. ( 29294155 )
2018
33
Successful management of concurrent acquired hemophilia A and a lupus anticoagulant in a pediatric hematopoietic stem cell transplant patient. ( 29330401 )
2018
34
Optimal donor for severe aplastic anemia patient requiring allogeneic hematopoietic stem cell transplantation: A large-sample study from China. ( 29410500 )
2018
35
Allogeneic Stem Cell Transplantation for Advanced Myelodysplastic Syndrome: Comparison of Outcomes between CD34<sup>+</sup>Selected and Unmodified Hematopoietic Stem Cell Transplantation. ( 29325829 )
2018
36
Second Malignancies after Hematopoietic Stem Cell Transplantation. ( 29423555 )
2018
37
Total Hip Arthroplasty in Patients With Avascular Necrosis After Hematopoietic Stem Cell Transplantation. ( 29451944 )
2018
38
Viral encephalitis after haplo-identical hematopoietic stem cell transplantation: Causative viral spectrum, characteristics, and risk factors. ( 28129450 )
2017
39
Early blood stream infection following allogeneic hematopoietic stem cell transplantation is a risk factor for acute grade III-IV GVHD in children and adolescents. ( 28921804 )
2017
40
Outcome of Second Transplantation Using Umbilical Cord Blood for Graft Failure after Allogeneic Hematopoietic Stem Cell Transplantation for Aplastic Anemia. ( 28844947 )
2017
41
Effect of donor STAT4 polymorphism rs7574865 on clinical outcomes of pediatric acute leukemia patients after hematopoietic stem cell transplant. ( 27960128 )
2017
42
Transmission of West Nile Virus Through a Hematopoietic Stem Cell Transplant. ( 29309636 )
2017
43
Hematopoietic Stem Cell Transplantation for Myelodysplastic Syndrome in a Child With Klinefelter Syndrome. ( 28902077 )
2017
44
Sphingosine 1-Phosphate Signaling and Its Pharmacological Modulation in Allogeneic Hematopoietic Stem Cell Transplantation. ( 28934113 )
2017
45
The impact of KIR2DS4 gene on clinical outcome after hematopoietic stem cell transplantation. ( 27998801 )
2017
46
Diagnosis and treatment of neoplastic post-transplant lymphoproliferative disorder following hematopoietic stem cell transplant in I^-thalassemia: A pediatric case report. ( 29384898 )
2017
47
Perspectives on the co-treatment with GnRHa in female patients undergoing hematopoietic stem cell transplantation. ( 28947558 )
2017
48
Design of the DREPAGREFFE trial: A prospective controlled multicenter study evaluating the benefit of genoidentical hematopoietic stem cell transplantation over chronic transfusion in sickle cell anemia children detected to be at risk of stroke by transcranial Doppler (NCT 01340404). ( 28821470 )
2017
49
Prognostic Impact of Donor Source on Allogeneic Hematopoietic Stem Cell Transplantation Outcomes in Adults with Chronic Myelomonocytic Leukemia: A Nationwide Retrospective Analysis in Japan. ( 29196081 )
2017
50
Nosocomial BK Polyomavirus Infection Causing Hemorrhagic Cystitis Among Patients With Hematological Malignancies After Hematopoietic Stem Cell Transplantation. ( 28295968 )
2017

Variations for Hematopoietic Stem Cell Transplantation

Expression for Hematopoietic Stem Cell Transplantation

Search GEO for disease gene expression data for Hematopoietic Stem Cell Transplantation.

Pathways for Hematopoietic Stem Cell Transplantation

Pathways related to Hematopoietic Stem Cell Transplantation according to GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.87 ARHGAP45 CLEC7A CTLA4 HLA-A HLA-B HLA-C
2
Show member pathways
13.47 CTLA4 HLA-A HLA-B HLA-C HLA-E KIR2DL1
3
Show member pathways
13.35 HLA-A HLA-B HLA-C HLA-E IFNG IL10
4
Show member pathways
13.01 HLA-A HLA-B HLA-C HLA-E IL2 IL6
5
Show member pathways
12.75 HLA-A HLA-B HLA-C HLA-E IFNG IL2
6
Show member pathways
12.63 IFNG IL10 IL2 IL6 TNF
7
Show member pathways
12.62 IFNG IL10 IL2 IL6 TNF
8
Show member pathways
12.61 HLA-A HLA-B HLA-C HLA-E IL6 TNF
9 12.6 CTLA4 IFNG IL10 IL2 TNF
10
Show member pathways
12.57 HLA-A HLA-B HLA-C HLA-E IFNG
11
Show member pathways
12.56 IFNG IL10 IL2 IL6 TNF
12
Show member pathways
12.51 CTLA4 HLA-A HLA-B HLA-C HLA-E IFNG
13
Show member pathways
12.47 HLA-A HLA-B HLA-C HLA-E
14
Show member pathways
12.46 CTLA4 IFNG IL10 IL2 IL6 TNF
15 12.4 HLA-A HLA-B HLA-C HLA-E
16
Show member pathways
12.39 IFNG IL10 IL2 IL6
17
Show member pathways
12.38 IFNG IL2 IL6 MTHFR TNF
18 12.38 HLA-A HLA-B HLA-C HLA-E IL2 IL6
19
Show member pathways
12.33 HLA-A HLA-B HLA-C HLA-E IFNG IL2
20 12.32 HLA-A HLA-B HLA-C HLA-E
21 12.29 HLA-A HLA-B HLA-C HLA-E IFNG IL10
22 12.28 CLEC7A IFNG IL10 IL6 TNF
23 12.18 CLEC7A HLA-A HLA-B HLA-C HLA-E
24 12.15 CTLA4 HLA-A HLA-B HLA-C HLA-E
25 12.07 HLA-A HLA-B HLA-C HLA-E IL6 KIR2DL1
26 12.05 IFNG IL2 IL6 TNF
27 12.02 IFNG IL10 IL2 IL6 TNF
28 11.96 IL10 IL6 TNF
29
Show member pathways
11.95 HLA-A IFNG IL2
30 11.94 IFNG IL10 IL6 TNF
31
Show member pathways
11.94 IFNG IL10 IL2 IL6 TNF
32 11.93 HLA-A HLA-B HLA-C HLA-E KIR2DL1 KIR2DL3
33 11.91 CTLA4 IFNG IL6 TNF
34 11.9 IFNG IL10 IL2 IL6
35 11.85 IFNG IL10 IL2 TNF
36
Show member pathways
11.82 CTLA4 IFNG IL2 TNF
37 11.81 IFNG IL2 IL6
38 11.77 IL10 IL6 TNF
39 11.75 CTLA4 IL10 IL6 TNF
40 11.74 IFNG IL10 IL2 IL6 TNF
41
Show member pathways
11.72 IFNG IL2 IL6 TNF
42
Show member pathways
11.7 HLA-A IFNG IL2 TNF
43 11.61 IFNG IL2 IL6 TNF
44 11.57 IL10 IL6 TNF
45 11.57 IFNG IL10 IL6 TNF
46 11.56 IFNG IL2 TNF
47 11.54 IFNG IL10 IL2
48 11.53 IFNG IL6 TNF
49
Show member pathways
11.49 HLA-A HLA-B HLA-C HLA-E IFNG IL10
50 11.4 IL10 IL6 TNF

GO Terms for Hematopoietic Stem Cell Transplantation

Cellular components related to Hematopoietic Stem Cell Transplantation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.95 CTLA4 HLA-A HLA-B KIR2DL1 KIR2DL3 KIR3DL1
2 cell surface GO:0009986 9.83 HLA-A HLA-B HLA-C HLA-E TNF
3 early endosome membrane GO:0031901 9.67 HLA-A HLA-B HLA-C HLA-E
4 phagocytic vesicle membrane GO:0030670 9.62 HLA-A HLA-B HLA-C HLA-E
5 recycling endosome membrane GO:0055038 9.56 HLA-A HLA-B HLA-C HLA-E
6 ER to Golgi transport vesicle membrane GO:0012507 9.46 HLA-A HLA-B HLA-C HLA-E
7 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.26 HLA-A HLA-B HLA-C HLA-E
8 MHC class I protein complex GO:0042612 8.92 HLA-A HLA-B HLA-C HLA-E
9 plasma membrane GO:0005886 10.2 ARHGAP45 CLEC7A CTLA4 HLA-A HLA-B HLA-C

Biological processes related to Hematopoietic Stem Cell Transplantation according to GeneCards Suite gene sharing:

(show all 29)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.99 CLEC7A CTLA4 HLA-A HLA-B HLA-C IL2
2 regulation of receptor activity GO:0010469 9.97 IFNG IL10 IL2 IL6 TNF
3 adaptive immune response GO:0002250 9.88 CTLA4 HLA-E IFNG IL2
4 positive regulation of DNA binding transcription factor activity GO:0051091 9.81 IL10 IL6 TNF
5 defense response to Gram-positive bacterium GO:0050830 9.8 HLA-E IL6 TNF
6 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 9.8 HLA-A HLA-B HLA-C HLA-E
7 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.77 IFNG IL2 IL6
8 response to glucocorticoid GO:0051384 9.77 IL10 IL6 TNF
9 type I interferon signaling pathway GO:0060337 9.76 HLA-A HLA-B HLA-C HLA-E
10 humoral immune response GO:0006959 9.74 IFNG IL6 TNF
11 antigen processing and presentation GO:0019882 9.71 HLA-A HLA-B HLA-C HLA-E
12 regulation of regulatory T cell differentiation GO:0045589 9.65 CTLA4 IFNG IL2
13 interferon-gamma-mediated signaling pathway GO:0060333 9.65 HLA-A HLA-B HLA-C HLA-E IFNG
14 negative regulation of B cell proliferation GO:0030889 9.64 CTLA4 IL10
15 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.64 IFNG TNF
16 negative regulation of growth of symbiont in host GO:0044130 9.63 IL10 TNF
17 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.62 IL10 TNF
18 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.62 HLA-A HLA-B HLA-C HLA-E
19 negative regulation of lipid storage GO:0010888 9.61 IL6 TNF
20 endothelial cell apoptotic process GO:0072577 9.61 IL10 TNF
21 positive regulation of immunoglobulin secretion GO:0051024 9.61 HLA-E IL2 IL6
22 negative regulation of cytokine secretion involved in immune response GO:0002740 9.56 IL10 TNF
23 receptor biosynthetic process GO:0032800 9.55 IL10 TNF
24 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.54 IFNG TNF
25 protection from natural killer cell mediated cytotoxicity GO:0042270 9.54 HLA-A HLA-B HLA-E
26 positive regulation of vitamin D biosynthetic process GO:0060557 9.52 IFNG TNF
27 regulation of immune response GO:0050776 9.5 HLA-A HLA-B HLA-C HLA-E KIR2DL1 KIR2DL3
28 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.46 HLA-A HLA-B HLA-C HLA-E
29 immune response GO:0006955 9.44 CTLA4 HLA-A HLA-B HLA-C HLA-E IFNG

Molecular functions related to Hematopoietic Stem Cell Transplantation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.35 IFNG IL10 IL2 IL6 TNF
2 beta-2-microglobulin binding GO:0030881 9.26 HLA-A HLA-E
3 peptide antigen binding GO:0042605 8.92 HLA-A HLA-B HLA-C HLA-E
4 protein binding GO:0005515 10.03 ARHGAP45 CLEC7A CTLA4 HLA-A HLA-B HLA-C

Sources for Hematopoietic Stem Cell Transplantation

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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