Summaries for Hematuria

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44Wikipedia, 22MalaCards
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Wikipedia: In medicine, hematuria, or haematuria, is the presence of red blood cells (erythrocytes) in the urine....44 more...

MalaCards: Hematuria is related to alport syndrome and hematuria, benign familial. An important gene associated with Hematuria is COL4A4 (collagen, type IV, alpha 4), and among its related pathways are Cell adhesion Endothelial cell contacts by non-junctional mechanisms and Cell adhesion_Endothelial cell contacts by non-junctional mechanisms. The compounds carbohydrates and hirudin have been mentioned in the context of this disorder. Affiliated tissues include kidney and prostate, and related mouse phenotypes are embryogenesis and other.

Aliases & Descriptions for Hematuria

Sources:
7diseasecard
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hematuria 7

Related Diseases for Hematuria

Sources:
13GeneCards, 14GeneDecks
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Diseases related to hematuria by text searches and GeneDecks gene sharing:

(show top 50)    (show all 317)
idRelated DiseaseScoreTop Affiliating Genes
1alport syndrome32.7COL4A5, COL4A6, COL4A3, COL4A4
2hematuria, benign familial31.8COL4A5, COL4A3, COL4A4
3collagen iv-related nephropathies (alport syndrome and thin basement membrane nephropathy)30.5COL4A5, COL4A3, COL4A4
4autosomal recessive alport syndrome28.1COL4A1, COL4A3, COL4A4
5membranoproliferative glomerulonephritis type 227.9CFP, CD79A, C3
6focal segmental glomerulosclerosis27.6NAGLU, CD79A, ACE
7glanzmann's thrombasthenia27.5FN1, F3, F10
8schistosomiasis26.5CD79A, CD40LG, INS, F3
9iga glomerulonephritis25.4NAGLU, CFP, CD79A, CD40LG, FN1, F10
10nephropathy24.7NAGLU, CFP, CD79A, CD40LG, FN1, INS
11glomerulonephritis24.3NAGLU, CFP, CD79A, CD40LG, FN1, INS
12proteinuria23.9PIK3C2A, NAGLU, CFP, CD79A, CD40LG, FN1
13retinitis23.1PIK3C2A, NAGLU, CD79A, CD40LG, FN1, INS
14prostatitis22.0PIK3C2A, NAGLU, BIRC5, CD79A, CD40LG, FN1
15autosomal dominant alport syndrome13.7COL4A3, COL4A4
16subacute bacterial endocarditis13.6CFP, PRTN3
17hypersensitivity vasculitis13.6CD79A, PRTN3
18infective endocarditis13.6CFP, PRTN3
19malignant cylindroma13.6COL4A1, COL4A5
20primary hyperoxaluria13.5NAGLU, AMBP
21collagen type vi-related disorders13.5COL6A3, COL6A1, COL6A2
22scleroatonic muscular dystrophy13.5COL6A3, COL6A1, COL6A2
23bethlem myopathy13.4COL6A3, COL6A1, COL6A2
24urinary tract obstruction13.4NAGLU, AMBP, SRD5A1
25muscle disorders13.4COL6A3, COL6A1, COL6A2
26creatine phosphokinase, elevated serum13.4PIK3C2A, MB
27leiomyomatosis13.4COL4A5, COL4A6, COL4A3, COL4A4
28acute kidney tubular necrosis13.4NAGLU, MB
29cd40 ligand deficiency13.4CD79A, CD40LG
30congenital toxoplasmosis13.4CD79A, CD40LG
31cryofibrinogenemia13.3CD79A, CD40LG, FN1
32goodpasture syndrome13.3CD79A, COL4A1, COL4A5, COL4A3
33silent myocardial infarction13.3PIK3C2A, INS
34secondary syphilis13.3CD79A, CD40LG, FN1
35mesangial proliferative glomerulonephritis13.3CD79A, FN1
36selective iga deficiency disease13.3CD79A, CD40LG
37immunodeficiency with hyper igm13.3CD79A, CD40LG
38sporotrichosis13.3CD79A, CD40LG
39ullrich congenital muscular dystrophy13.2PIK3C2A, COL6A3, COL6A1, COL6A2
40gas gangrene13.2PIK3C2A, MB
41ankylosing spondylitis13.2CD79A, CD40LG, PRTN3
42syphilis13.2CD79A, CD40LG, FN1
43pure red-cell aplasia13.2PIK3C2A, CD79A, CD40LG
44lactic acidosis13.2PIK3C2A, NAGLU, MB
45dysphagia13.2PIK3C2A, F3, PRTN3
46diabetic angiopathy13.2NAGLU, FN1, INS
47al amyloidosis13.1CD79A, CD40LG, F10
48immunodeficiency, centromere instability and facial anomalies syndrome13.1CD79A, CD40LG
49keratoconus13.1FN1, COL4A1, COL4A3, COL4A4, COL6A1
50factor x deficiency13.1F3, F10

Graphical network of the top 20 diseases related to hematuria:



Graphical network of diseases related to hematuria

Clinical Features for Hematuria

Drugs & Therapeutics for Hematuria

Sources:
4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
See all sources

Approved drugs:

Search CenterWatch for hematuria

Drug clinical trials:

Search ClinicalTrials for hematuria

Search NIH Clinical Center for hematuria

Search CenterWatch for hematuria

Genetic Tests for Hematuria

Anatomical Context for Hematuria

Sources:
22MalaCards
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MalaCards organs/tissues related to hematuria:

22
Kidney, Prostate

Phenotypes for genes affiliated with Hematuria

Sources:
25MGI
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MGI Mouse Phenotypes related to hematuria:

25 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1embryogenesis phenotypeMP:00053809.4BIRC5, MB, NOTCH4
2other phenotypeMP:00053959.2C3, CD40LG, FN1, COL4A1, COL4A3
3hematopoietic system phenotypeMP:00053979.1MB, COL4A1, FHIT
4renal/urinary system phenotypeMP:00053679.0COL4A4, NAGLU, INS, COL4A5, C3, COL4A3
5immune system phenotypeMP:00053878.9COL4A5, NAGLU, CFP, CD79A, FN1, FHIT
6normal phenotypeMP:00028737.6BIRC5, C3, COL4A6, NOTCH4, CALB2, F3
7growth/size phenotypeMP:00053787.5PIK3C2A, ACE, COL4A4, COL4A3, COL4A1, NOTCH4
8cardiovascular system phenotypeMP:00053856.8FN1, NAGLU, CFP, ACE, INS, MB
9mortality/agingMP:00107686.6COL4A1, ACE, COL4A4, COL4A3, CFP, COL4A5
10cellular phenotypeMP:00053846.2C3, ACE, COL6A1, COL4A1, F3, NAGLU
11homeostasis/metabolism phenotypeMP:00053764.9COL4A3, FN1, PIK3C2A, BIRC5, CFP, CD79A

Publications for genes affiliated with Hematuria

Sources:
35PubMed
See all sources

Articles related to hematuria:

(show all 34)
idTitleAuthorsYearAffiliating Genes
1A family with X-linked benign familial hematuria. (19937058)Kaneko K.... Takemura T.2010COL4A3, COL4A5, COL4A4
2Molecular analysis of the fragile histidine triad (FHIT) tumor suppressor gene in vesical tumors of cattle with chronic enzootic hematuria (CEH). (18467844)Guidi E.... Ferretti L.2008FHIT
3COL4A3/COL4A4 mutations link familial hematuria and focal segmental glomerulosclerosis. glomerular epithelium destruction via basement membrane thinning? (18661361)Voskarides K.... Deltas C.2008COL4A3, COL4A4
4Identification of two novel mutations C79X and R235Q in the dihydropyrimidine dehydrogenase gene in a patient presenting with hematuria. (18600544)Van Kuilenburg A.B.... Buzing C.2008DPYD
5Persistent prostatic hematuria. (18253111)Rastinehad A.R.... Kavoussi L.R.2008SRD5A1
6True adrenal mesothelial cyst in a patient with flank pain and hematuria: a case report. (18446449)Suh J.... Cohen H.2008CALB2
7Gross hematuria due to acquired haemophilia in hereditary hemorrhagic telangiectasia. (18832920)De Pascalis A.... Buongiorno E.2008F3
8Post-coital gross hematuria: an unusual presentation of benign prostatic hyperplasia. (17968474)Chen Y.H.... Lin Y.M.2007SRD5A1
9Natural history and prognostic factors of IgA nephrop athy presented with isolated microscopic hematuria in Chinese patients. (17596724)Shen P.... Chan M.2007CD79A
10Sixteen novel mutations identified in COL4A3, COL4A4, and COL4A5 genes in Slovenian families with Alport syndrome and benign familial hematuria. (17396119)Slajpah M.... Glavac D.2007COL4A3, COL4A5, COL4A4
11Detection of newly diagnosed bladder cancer, bladder cancer recurrence and bladder cancer in patients with hematuria using quantitative rt-PCR of urinary survivin. (17259754)Kenney D.M.... Li Z.Q.2007BIRC5
12Clinical spectrum of gross hematuria in pediatric patients. (16528433)Youn T.... Gauthier B.2006CD79A
13Persistent familial hematuria in children and the locus for thin basement membrane nephropathy. (16235097)Rana K.... Savige J.2005COL4A3, COL4A4
14Autosomal-dominant familial hematuria with retinal arteriolar tortuosity and contractures: a novel syndrome. (15882279)Plaisier E.... Ronco P.2005COL6A1, NOTCH4, COL6A2
15Value of urinary excretion of microalbumin in predicting glomerular lesions in children with isolated microscopic hematuria. (15942787)Assadi F.K.2005ACE
16From Alport syndrome to benign familial hematuria: clinical and genetic aspect (16895672)Maziers N.... Pirson Y.2005COL4A3, COL4A4
17Hematuria and acanthocyturia in patients with diabetes (16372748)Ono Y.... Yasujima M.2005CD79A
18Mild rhabdomyolysis in a child with fever and 'hematuria'. (12736809)Tasic V.... Korneti P.2003MB
19Autosomal recessive Alport's syndrome and benign familial hematuria are collagen type IV diseases. (14582039)Tazon Vega B.... Torra R.2003COL4A3, COL4A4
20COL4A3/COL4A4 mutations: from familial hematuria to autosomal-dominant or recessive Alport syndrome. (12028435)Longo I.... de Marchi M.2002COL4A3, COL4A4
21Mutations in the COL4A4 and COL4A3 genes cause familial benign hematuria. (11961012)Badenas C.... Torra R.2002COL4A3, COL4A4
22Acute renal failure in IgA nephropathy: aggravation by gross hematuria due to anticoagulant treatment. (12495289)August C.... Lang D.2002CD79A
23Segregation of hematuria in thin basement membrane disease with haplotypes at the loci for Alport syndrome. (11318937)Buzza M.... Savige J.2001COL4A5
24Benign familial hematuria associated with a novel COL4A4 mutation. (11685592)Ozen S.... Antignac C.2001COL4A4
25Recurrent hematuria: a novel clinical presentation of hereditary complete complement C4 deficiency. (8604713)Lhotta K.... Konig P.1996C3, CD40LG, CD79A
26Identification of 17 mutations in ten exons in the COL4A5 collagen gene, but no mutations found in four exons in COL4A6: a study of 250 patients with hematuria and suspected of having Alport syndrome. (8738805)Heiskari N.... Tryggvason K.1996COL4A6, COL4A5
27Benign familial hematuria due to mutation of the type IV collagen alpha4 gene. (8787673)Lemmink H.H.... Smeets H.J.M.1996COL4A3, COL4A4
28Serum tumor necrosis factor in mesangial IgA glomerulonephritis with macroscopic hematuria in children. (8730414)Inaba S.... Okada T.1996CD79A
29Mutation in alpha 5(IV) collagen chain gene in nonfamilial hematuria. (7579094)Kitagawa K.... Yoshikawa N.1995COL4A5
30The clinico-pathological significance of hematuria in diabetics (7967175)Matsumura N.... Dohi K.1994INS
31Microalbumin excretion in the group of patients with asymptomatic hematuria (1352833)Nakamura S.... Azuma T.1992NAGLU
32Quantitative assessment of mesangial immunoglobulin A (IgA) accumulation, elevated circulating IgA immune complexes, and hematuria during vomitoxin-induced IgA nephropathy. (1833256)Dong W.... Pestka J.J.1991CD79A
33Clinicopathological study of patients presenting hematuria and proteinuria by renal biopsy (2046202)Shinohara Y.... Hayashida S.1991CD79A
34Differentiation of hematuria by quantitative determination of urinary marker proteins. (1709219)Hofmann W.... Edel H.H.1991AMBP

Expression for genes affiliated with Hematuria

Sources:
1BioGPS
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Expression patterns in normal tissues for genes affiliated with Hematuria

Pathways for genes affiliated with Hematuria

Sources:
10EMD Millipore, 41Thomson Reuters, 34PharmGKB, 37R&D Systems, 20KEGG, 38Reactome, 36QIAGEN
See all sources

Pathways related to hematuria according to GeneDecks:

(show all 35)
idPathwayScoreTop Affiliating Genes
1Cell adhesion Endothelial cell contacts by non-junctional mechanisms109.7COL4A4, COL4A6, COL4A3, COL4A5, COL4A1, FN1
2Cell adhesion_Endothelial cell contacts by non-junctional mechanisms419.7COL4A5, FN1, COL4A1, COL4A4, COL4A6, COL4A3
3Cell adhesion Plasmin signaling109.7COL4A6, COL4A3, COL4A4, COL4A5, COL4A1, FN1
4Cell adhesion_Plasmin signaling419.6FN1, COL4A1, COL4A6, COL4A3, COL4A4, COL4A5
5Metalloproteases in connective tissue degradation109.6FN1, COL4A1, COL4A5, COL4A6, COL4A3, COL4A4
6Cell adhesion ECM remodeling109.6COL4A1, COL4A5, COL4A6, COL4A3, COL4A4, FN1
7Cell adhesion_ECM remodeling419.6COL4A1, COL4A5, COL4A6, COL4A3, COL4A4, FN1
8Cytoskeleton remodeling Integrin outside-in signaling109.6COL4A4, FN1, COL4A3, COL4A6, COL4A5, COL4A1
9Platelet Aggregation Inhibitor Pathway, Pharmacodynamics349.6COL4A3, COL4A6, COL4A5, COL4A1, COL4A4
10Cytoskeleton remodeling_Integrin outside-in signaling419.6COL4A6, FN1, COL4A1, COL4A3, COL4A5, COL4A4
11Cell adhesion_Integrin-mediated cell adhesion and migration419.5COL4A6, COL4A5, COL4A1, FN1, COL4A3, COL4A4
12Cell adhesion Integrin-mediated cell adhesion and migration109.5COL4A3, COL4A6, COL4A1, FN1, COL4A5, COL4A4
13Blood Coagulation Signaling Pathways379.5COL4A1, F10, F3
14Protein digestion and absorption209.4COL4A1, COL4A5, COL6A3, COL4A6, COL6A1, COL4A4
15Amoebiasis209.3COL4A6, COL4A4, COL4A5, COL4A1, FN1
16Axon guidance389.3COL6A2, COL6A1, COL4A4, COL4A3, COL6A3, COL4A1
17ECM-receptor interaction209.2COL6A1, COL6A2, COL4A6, FN1, COL4A1, COL4A5
18Focal adhesion209.2COL4A5, COL6A2, COL6A1, COL4A4, COL4A6, COL6A3
19Inhibition of Angiogenesis by TSP1369.1COL4A4, COL4A6, COL4A3, COL6A1, COL6A2, COL4A5
20UPA-UPAR Pathway369.1COL4A1, FN1, COL6A2, COL4A5, COL6A3, COL4A6
21FAK1 Signaling369.1COL6A3, FN1, COL4A1, COL4A5, COL4A6, COL4A3
22Integrin Pathway369.1COL4A5, COL4A1, FN1, COL4A4, COL6A3, COL4A6
23GnRH Signaling369.0COL4A4, COL4A3, COL4A6, COL4A1, FN1, COL4A5
24PTEN Pathway369.0COL4A5, COL6A3, COL4A6, COL4A3, COL4A4, FN1
25Transendothelial Migration of Leukocytes369.0COL6A1, COL6A2, COL4A4, COL4A3, COL4A6, COL6A3
26Intrinsic Prothrombin Activation Pathway368.9F10, COL6A1, COL4A4, COL4A6, COL4A3, COL4A1
27ILK Signaling368.9COL6A2, COL4A1, FN1, COL6A1, COL4A4, COL4A3
28Small cell lung cancer208.9FN1, FHIT, COL4A5, COL4A6, COL4A4, COL4A1
29MAPK Signaling368.9COL6A2, COL6A1, COL4A5, COL4A1, FN1, COL6A3
30Phospholipase-C Pathway368.9COL6A2, COL4A1, FN1, CD79A, COL6A3, COL4A5
31Pathways in cancer208.9COL4A4, COL4A5, COL4A1, BIRC5, COL4A6
32Rho Family GTPases368.8FN1, COL4A1, COL4A5, COL6A3, COL4A6, COL4A3
33ERK Signaling368.7COL6A2, COL6A1, COL4A4, COL4A3, COL4A1, COL4A6
34Molecular Mechanisms of Cancer368.7COL6A2, COL6A1, COL4A4, COL4A5, FN1, NOTCH4
35Blood Coagulation Cascade368.6COL4A1, F10, F3, COL4A5, COL6A3, COL4A6

Compounds for genes affiliated with Hematuria

Sources:
32Novoseek , 9DrugBank, 18HMDB, 34PharmGKB, 42Tocris Bioscience
See all sources

Compounds related to hematuria according to GeneDecks:

(show top 50)    (show all 97)
idCompoundScoreTop Affiliating Genes
1carbohydrates32 10.6F10
2hirudin32 10.5F10
3phosphorus32 10.5CFP, NAGLU
4calcium oxalate32 10.2AMBP, FN1, NAGLU
5phosphatidylserine32 9 9 12.2PRTN3, CD79A, F10
6polyethylene glycol32 10.0MB, FN1, F10
7hyaluronic acid32 18 11.0CALB2, MB, PRTN3, FN1
8vancomycin32 9 9 11.9MB, CD79A, CD40LG
9ascorbic acid32 18 10.9F10, CD40LG, CFP
10guanidine hydrochloride32 9.8AMBP, FN1, F10, F3
11silicone32 9.8FN1, CD40LG, CD79A, F10
12pmma32 9.8MB, CD79A, FN1, CD40LG
13citrate32 9.7PIK3C2A, NAGLU, CD79A, F10, MB
14aprotinin32 9 9 11.7MB, F10, AMBP, FN1, NAGLU
15ppack32 9.7F3, CD40LG, F10
16neopterin32 9.5CD79A, CD40LG, C3, NAGLU
17heparin32 9 18 9 12.5PIK3C2A, F10, F3, FN1, CD79A, CFP
18clopidogrel32 34 9 18 9 13.5F10, CD40LG, ACE
19melphalan32 9 9 11.5MB, PIK3C2A, BIRC5, CD79A
20cardiolipin32 9 9 11.5PRTN3, CD79A, CD40LG, F3, F10
21dextran sulfate32 9.4FN1, F10, F3, CD40LG, CFP
22rituximab32 34 9 9 12.3PRTN3, CD79A, CD40LG, BIRC5
23warfarin32 34 9 18 9 13.2F10, PIK3C2A, CD79A, F3, ACE
24n acetylcysteine32 9.2FHIT, BIRC5, NAGLU, CD79A
25thyroxine32 18 10.1MB, INS, CD40LG, CD79A, PIK3C2A
26tacrolimus32 34 9 9 12.1F3, INS, FN1, NAGLU, CD79A
27tirofiban32 9 9 11.1CD40LG, F10, F3
28aspartate32 9.1F10, AMBP, MB, CD40LG, NAGLU, PIK3C2A
29ramipril32 9 9 11.1ACE, INS, CD79A
30acetylcholine32 9 18 9 12.0CD40LG, CALB2, CD79A, PIK3C2A, MB, F10
31vitamin a32 9 18 9 12.0AMBP, C3, MB, CD40LG, BIRC5, NAGLU
32polysaccharide32 8.9CFP, CD79A, CD40LG, C3, FN1, F3
33epinephrine32 9 18 9 11.8MB, INS, PIK3C2A, CD40LG, CD79A, F3
34cyclosporin a32 42 9.6COL4A3, CD79A, NAGLU, FN1, FHIT, PIK3C2A
35norepinephrine32 9 18 9 11.4PIK3C2A, MB, ACE, INS, CD40LG, CD79A
36aspirin32 34 18 10.4BIRC5, CD40LG, FN1, F3, F10, CD79A
37arginine32 8.3MB, FN1, F10, CD40LG, CD79A, INS
38fibrinogen32 8.3C3, F10, F3, AMBP, INS, FN1
39cysteine32 8.3MB, NAGLU, CD79A, CD40LG, FN1, AMBP
40testosterone32 9 18 9 11.2PIK3C2A, BIRC5, CD40LG, INS, MB, CALB2
41steroid32 7.9NAGLU, BIRC5, CD79A, FN1, FHIT, AMBP
42paraffin32 7.7CALB2, MB, FHIT, FN1, BIRC5, CD40LG
43retinoic acid32 42 18 9.7FN1, FHIT, CD40LG, F3, SRD5A1, PRTN3
44creatinine32 7.5INS, NAGLU, PIK3C2A, FN1, C3, CD79A
45alanine32 7.4PRTN3, F10, F3, PIK3C2A, NAGLU, BIRC5
46vegf32 7.4CD79A, PIK3C2A, BIRC5, CD40LG, NOTCH4, DPYD
47serine32 7.3MB, AMBP, F3, FN1, C3, COL4A5
48cisplatin32 34 9 9 10.3CD40LG, FHIT, AMBP, F10, DPYD, PIK3C2A
49lactate32 6.9INS, C3, F10, AMBP, FHIT, FN1
50estrogen32 6.6PRTN3, DPYD, SRD5A1, CALB2, F10, FN1

GO Terms for genes affiliated with Hematuria

Sources:
12Gene Ontology
See all sources

Cellular components related to hematuria according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1collagen type VIGO:0055899.9COL6A3, COL6A1
2transport vesicleGO:0301339.8COL6A2, COL6A1, COL6A3
3collagen type IVGO:0055879.6COL4A4, COL4A3, COL4A6, COL4A5, COL4A1
4intrinsic to external side of plasma membraneGO:0312339.5F10, F3
5extracellular matrixGO:0310128.8FN1, COL4A1, CFP, F3, COL6A3, COL6A1
6endoplasmic reticulum lumenGO:0057888.2COL4A3, COL4A1, COL6A2, COL6A1, INS, F10
7extracellular spaceGO:0056157.5INS, CD40LG, F3, COL6A3, CFP, COL6A2
8extracellular regionGO:0055767.0NOTCH4, F10, AMBP, COL4A1, INS, FN1

Biological processes related to hematuria according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular response to amino acid stimulusGO:0712309.7COL4A1, COL4A6, COL6A1
2blood coagulation, extrinsic pathwayGO:0075989.5F10, F3
3positive regulation of protein kinase B signaling cascadeGO:0518979.3F3, F10, INS
4axon guidanceGO:0074119.2COL6A2, COL6A1, COL4A4, COL4A3, COL6A3, COL4A5
5cell adhesionGO:0071559.1FN1, AMBP, COL6A1, COL4A3, COL4A6, COL6A3
6extracellular matrix organizationGO:0301989.0COL6A3, COL4A3, COL4A6, COL4A4, COL6A1, COL6A2

Molecular functions related to hematuria according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix structural constituentGO:0052019.1FN1, COL4A1, COL4A5, COL4A6, COL4A3, COL4A4

Sources for Hematuria

2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS