MCID: HMF006
MIFTS: 54

Hemifacial Microsomia malady

Categories: Genetic diseases, Rare diseases, Eye diseases, Ear diseases, Bone diseases, Fetal diseases

Aliases & Classifications for Hemifacial Microsomia

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Sources:
50OMIM, 11Disease Ontology, 46NIH Rare Diseases, 23GeneTests, 52Orphanet, 12diseasecard, 13DISEASES, 37MeSH, 66UMLS, 25GTR, 28ICD10, 43NCIt, 29ICD10 via Orphanet, 38MESH via Orphanet, 67UMLS via Orphanet, 60SNOMED-CT, 62The Human Phenotype Ontology
See all MalaCards sources

Aliases & Descriptions for Hemifacial Microsomia:

Name: Hemifacial Microsomia 50 11 46 23 52 12
Goldenhar Syndrome 11 46 23 13 52 37 66
First and Second Branchial Arch Syndrome 11 46 23
Otomandibular Dysostosis 11 23 52
Expanded Spectrum of Hemifacial Microsomia 46 52
Facioauriculovertebral Dysplasia 46 52
Oculoauriculovertebral Dysplasia 46 52
Oculoauriculovertebral Syndrome 46 52
Goldenhar Disease 46 25
Oav Dysplasia 46 52
 
Oavs 46 52
Goldenhar Syndrome with Ipsilateral Radial Defect 66
Facio-Auriculo-Vertebral Spectrum 11
Facioauriculovertebral Sequence 46
First Branchial Arch Syndrome 52
Laterofacial Microsomia 52
Otomandibular Syndrome 52
First Arch Syndrome 11
Oav Dysplasia 11
Fav Sequence 46

Characteristics:

Orphanet epidemiological data:

52
goldenhar syndrome:
Inheritance: Autosomal dominant,Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: Antenatal,Neonatal; Age of death: normal life expectancy

HPO:

62
hemifacial microsomia:
Inheritance: autosomal dominant inheritance


Classifications:



External Ids:

OMIM50 164210
Disease Ontology11 DOID:2907
ICD1028 Q87.0
MeSH37 D006053
NCIt43 C84740
ICD10 via Orphanet29 Q87.0, Q75.8
MESH via Orphanet38 D006053
UMLS via Orphanet67 C0265240, C0432130

Summaries for Hemifacial Microsomia

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NIH Rare Diseases:46 Goldenhar disease is a condition that is present at birth and mainly affects the development of the eye, ear and spine.  the main characteristics are facial asymmetry (one side of the face is different from the other),  a partially formed ear (microtia) or totally absent ear (anotia), noncancerous (benign) growths of the eye (ocular dermoid cysts), and spinal abnormalities. goldenhar disease may also affect the heart, lungs, kidneys, and central nervous system. it is due to problems that occur when the fetus is forming within the womb of the mother, in structures known as the "first and second brachial arch". these structures will develop to form the neck and the head. the cause is still unknown. goldenhar syndrome is part of a group of conditions known as "craniofacial microsomia". it is not known whether the conditions included in the group really are different conditions or part of the same problem with different degrees of severity. treatment is age-dependent, with interventions at appropriate stages of skull and face growth and development. last updated: 4/23/2016

MalaCards based summary: Hemifacial Microsomia, also known as goldenhar syndrome, is related to hemifacial microsomia with radial defects and craniofacial microsomia, and has symptoms including facial asymmetry, micrognathia and hearing impairment. An important gene associated with Hemifacial Microsomia is HFM (Hemifacial Microsomia), and among its related pathways is Transcriptional regulation of pluripotent stem cells. Affiliated tissues include eye, kidney and lung, and related mouse phenotypes are hearing/vestibular/ear and vision/eye.

Disease Ontology:11 A syndrome that is characterized by incomplete development of the ear, nose, soft palate, lip, and mandible. it is associated with anomalous development of the first branchial arch and second branchial arch.

OMIM:50 Hemifacial microsomia is a common birth defect involving the first and second branchial arch derivatives. It typically... (164210) more...

Wikipedia:69 Hemifacial microsomia is a congenital disorder that affects the development of the lower half of the... more...

Related Diseases for Hemifacial Microsomia

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Diseases related to Hemifacial Microsomia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)
idRelated DiseaseScoreTop Affiliating Genes
1hemifacial microsomia with radial defects12.3
2craniofacial microsomia11.6
3oculo-auriculo-vertebral spectrum11.0
4lateral facial dysplasia10.8
5vacterl association10.7
6pseudohypoparathyroidism ia10.3SALL1, SALL4
7dysostosis10.3
8stuttering, familial persistent, 410.2SALL1, SALL4
9microtia10.2
10orbital granuloma10.2SALL1, SALL4
11klippel-feil syndrome10.2
12cleft lip10.1
13sirenomelia10.1
14ureter small cell carcinoma10.0ALX3, HOXA2
15intracranial berry aneurysm10.0ALX3, SATB2
16book syndrome10.0ALX3, SATB2
17thrombocytopenia-absent radius syndrome10.0SALL4, SATB2
18optic nerve hypoplasia10.0
19townes-brocks syndrome10.0
20cat eye syndrome10.0
21cri-du-chat syndrome10.0
22femoral-facial syndrome10.0
23cerebellar hypoplasia10.0
24lymphedema10.0
25inguinal hernia10.0
26microphthalmia10.0
27heart disease10.0
28facial paralysis10.0
29congenital heart disease10.0
30ankylosis10.0
31pancreatitis10.0
32skin tag10.0
33gigantism10.0
34hypotonia10.0
35ptosis9.9
36central core myopathy9.9
37myopathy9.9
38agnathia-otocephaly complex9.9ALX3, OTX2
39autosomal dominant microcephaly9.9HOXA2, OTX2, SALL1
40pancreatic and cerebellar agenesis9.6FRAS1, HOXA2, SALL1
41cornelia de lange syndrome 59.6FRAS1, HOXA2, OTX2
42mental retardation, autosomal recessive 469.6ALX3, HOXA2
43foramen magnum meningioma9.5OTX2, PTCH1
44microphthalmia, isolated 16.8ALX3, FRAS1, HFM, HOXA2, OTX2, PTCH1

Graphical network of the top 20 diseases related to Hemifacial Microsomia:



Diseases related to hemifacial microsomia

Symptoms for Hemifacial Microsomia

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Symptoms by clinical synopsis from OMIM:

164210

Clinical features from OMIM:

164210

Symptoms:

 52 (show all 44)
  • ectopic kidney
  • renal agenesis
  • wide mouth
  • cleft palate
  • malar flattening
  • facial asymmetry
  • hypoplasia of the maxilla
  • micrognathia
  • abnormality of the inner ear
  • hearing impairment
  • low-set, posteriorly rotated ears
  • abnormality of the middle ear
  • preauricular skin tag
  • atresia of the external auditory canal
  • visual impairment
  • anophthalmia
  • microphthalmos
  • abnormality of the pharynx
  • upper eyelid coloboma
  • autism
  • abnormality of the ribs
  • epibulbar dermoid
  • intellectual disability
  • muscular hypotonia
  • agenesis of corpus callosum
  • laryngomalacia
  • ventricular septal defect
  • tetralogy of fallot
  • pulmonary hypoplasia
  • ventriculomegaly
  • cerebral cortical atrophy
  • neurological speech impairment
  • tracheoesophageal fistula
  • scoliosis
  • tracheomalacia
  • hemivertebrae
  • block vertebrae
  • short stature
  • vertebral hypoplasia
  • microtia
  • unilateral external ear deformity
  • feeding difficulties in infancy
  • aplasia/hypoplasia of the thumb
  • non-midline cleft lip

HPO human phenotypes related to Hemifacial Microsomia:

(show all 79)
id Description Frequency HPO Source Accession
1 facial asymmetry hallmark (90%) HP:0000324
2 micrognathia hallmark (90%) HP:0000347
3 hearing impairment hallmark (90%) HP:0000365
4 preauricular skin tag hallmark (90%) HP:0000384
5 cleft palate typical (50%) HP:0000175
6 micrognathia typical (50%) HP:0000347
7 abnormality of the inner ear typical (50%) HP:0000359
8 low-set, posteriorly rotated ears typical (50%) HP:0000368
9 abnormality of the middle ear typical (50%) HP:0000370
10 preauricular skin tag typical (50%) HP:0000384
11 atresia of the external auditory canal typical (50%) HP:0000413
12 epibulbar dermoid typical (50%) HP:0001140
13 neurological speech impairment typical (50%) HP:0002167
14 abnormal form of the vertebral bodies typical (50%) HP:0003312
15 non-midline cleft lip typical (50%) HP:0100335
16 wide mouth occasional (7.5%) HP:0000154
17 visual impairment occasional (7.5%) HP:0000505
18 abnormality of the pharynx occasional (7.5%) HP:0000600
19 cleft eyelid occasional (7.5%) HP:0000625
20 autism occasional (7.5%) HP:0000717
21 abnormality of the ribs occasional (7.5%) HP:0000772
22 muscular hypotonia occasional (7.5%) HP:0001252
23 laryngomalacia occasional (7.5%) HP:0001601
24 ventricular septal defect occasional (7.5%) HP:0001629
25 tetralogy of fallot occasional (7.5%) HP:0001636
26 ventriculomegaly occasional (7.5%) HP:0002119
27 cerebral cortical atrophy occasional (7.5%) HP:0002120
28 tracheoesophageal fistula occasional (7.5%) HP:0002575
29 scoliosis occasional (7.5%) HP:0002650
30 tracheomalacia occasional (7.5%) HP:0002779
31 vertebral segmentation defect occasional (7.5%) HP:0003422
32 short stature occasional (7.5%) HP:0004322
33 aplasia/hypoplasia of the lungs occasional (7.5%) HP:0006703
34 aplasia/hypoplasia of the corpus callosum occasional (7.5%) HP:0007370
35 aplasia/hypoplasia affecting the eye occasional (7.5%) HP:0008056
36 renal hypoplasia/aplasia occasional (7.5%) HP:0008678
37 aplasia/hypoplasia of the thumb occasional (7.5%) HP:0009601
38 abnormal localization of kidney occasional (7.5%) HP:0100542
39 cognitive impairment occasional (7.5%) HP:0100543
40 multicystic kidney dysplasia HP:0000003
41 ureteropelvic junction obstruction HP:0000074
42 vesicoureteral reflux HP:0000076
43 ectopic kidney HP:0000086
44 renal agenesis HP:0000104
45 wide mouth HP:0000154
46 cleft palate HP:0000175
47 cleft upper lip HP:0000204
48 hydrocephalus HP:0000238
49 malar flattening HP:0000272
50 facial asymmetry HP:0000324
51 hypoplasia of the maxilla HP:0000327
52 micrognathia HP:0000347
53 preauricular skin tag HP:0000384
54 conductive hearing impairment HP:0000405
55 sensorineural hearing impairment HP:0000407
56 atresia of the external auditory canal HP:0000413
57 strabismus HP:0000486
58 anophthalmia HP:0000528
59 microphthalmia HP:0000568
60 blepharophimosis HP:0000581
61 upper eyelid coloboma HP:0000636
62 epibulbar dermoid HP:0001140
63 intellectual disability HP:0001249
64 agenesis of corpus callosum HP:0001274
65 ventricular septal defect HP:0001629
66 tetralogy of fallot HP:0001636
67 patent ductus arteriosus HP:0001643
68 coarctation of aorta HP:0001680
69 occipital encephalocele HP:0002085
70 pulmonary hypoplasia HP:0002089
71 arnold-chiari malformation HP:0002308
72 hemivertebrae HP:0002937
73 block vertebrae HP:0003305
74 hypoplasia of facial musculature HP:0004660
75 vertebral hypoplasia HP:0008417
76 microtia HP:0008551
77 unilateral external ear deformity HP:0008605
78 branchial anomaly HP:0009794
79 anotia HP:0009892

Drugs & Therapeutics for Hemifacial Microsomia

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Drugs for Hemifacial Microsomia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
PregabalinPhase 4348148553-50-85486971
Synonyms:
(3S)-3-(aminomethyl)-5-methylhexanoic acid
(R-)-3-isobutyl GABA
(S)-3-(Aminomethyl)-5-methylhexanoic acid
(S)-3-Isobutyl gaba
(S+)-3-isobutyl GABA
121GE001
148553-50-8
3-Isobutyl gaba
3-isobutyl GABA
AC-1158
AC1NUP03
AKOS005145504
C080245
C8H17NO2
CHEBI:236161
CHEMBL1059
CI 1008
CI-1008
CID5486971
 
D02716
DB00230
FT-0080911
HSDB 7530
LS-75191
Lyrica
Lyrica (TN)
MolPort-000-861-733
PD 144723
PD-144723
Pregabalin
Pregabalin (JAN/USAN/INN)
Pregabalin [USAN]
Pregablin
S-(+)-3-isobutylgaba
S1731_Selleck
SBB062901
TL8001062
TOS-BB-0910
UNII-55JG375S6M
2calcium channel blockersPhase 41889

Interventional clinical trials:

idNameStatusNCT IDPhase
1Examination of Pregabalin Access for Treatment of Indicated Pain Disorders: the ExPAND StudyTerminatedNCT01280747Phase 4
2Clinical Trial of Fat Grafts Supplemented With Adipose-derived Regenerative CellsCompletedNCT01674439Phase 2
3Positive Exposure: A Photography and Video Intervention for Individuals With Craniofacial DifferencesCompletedNCT00340964
4Craniofacial Microsomia: Longitudinal Outcomes in Children Pre-Kindergarten (CLOCK)RecruitingNCT02224677
5Natural History of Craniofacial Anomalies and Developmental Growth VariantsRecruitingNCT02639312
6Role of Mesenchymal Stem Cells in Fat GraftingNot yet recruitingNCT02494752

Search NIH Clinical Center for Hemifacial Microsomia


Cochrane evidence based reviews: goldenhar syndrome

Genetic Tests for Hemifacial Microsomia

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Genetic tests related to Hemifacial Microsomia:

id Genetic test Affiliating Genes
1 Goldenhar Syndrome25 23
2 First and Second Branchial Arch Syndrome23
3 Hemifacial Microsomia23
4 Otomandibular Dysostosis23

Anatomical Context for Hemifacial Microsomia

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MalaCards organs/tissues related to Hemifacial Microsomia:

34
Eye, Kidney, Lung, Heart, Trachea, Bone, Skin

Animal Models for Hemifacial Microsomia or affiliated genes

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MGI Mouse Phenotypes related to Hemifacial Microsomia:

39 (show all 14)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053779.4HOXA2, OTX2, SALL1, SALL4
2MP:00053917.8ALX3, FRAS1, OTX2, PTCH1, SALL4
3MP:00036317.7ALX3, HOXA2, OTX2, PTCH1, SALL1, SALL4
4MP:00053887.5ALX3, FRAS1, HOXA2, OTX2, PTCH1, SATB2
5MP:00053867.4ALX3, HOXA2, OTX2, PTCH1, SALL1, SALL4
6MP:00053807.4ALX3, HOXA2, OTX2, PTCH1, SALL1, SALL4
7MP:00053847.3ALX3, FRAS1, HOXA2, OTX2, PTCH1, SALL1
8MP:00053827.2ALX3, FRAS1, HOXA2, OTX2, PTCH1, SALL4
9MP:00053857.0FRAS1, HOXA2, OTX2, PTCH1, SALL1, SALL4
10MP:00053717.0ALX3, FRAS1, PTCH1, SALL1, SALL4, SATB2
11MP:00053816.7ALX3, FRAS1, HOXA2, OTX2, PTCH1, SALL1
12MP:00107686.6ALX3, FRAS1, HOXA2, OTX2, PTCH1, SALL1
13MP:00053786.4ALX3, FRAS1, HOXA2, OTX2, PTCH1, SALL1
14MP:00053906.4ALX3, FRAS1, HOXA2, OTX2, PTCH1, SALL1

Publications for Hemifacial Microsomia

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Articles related to Hemifacial Microsomia:

(show top 50)    (show all 56)
idTitleAuthorsYear
1
Bimaxillary Orthognathic Approach to Correct Skeletal Facial Asymmetry of Hemifacial Microsomia in Adults. (26908014)
2016
2
Clinico-Radiologic Perspective of a Case of Hemifacial Microsomia. (26894197)
2016
3
Computer-Assisted Distraction Osteogenesis in the Treatment of Hemifacial Microsomia. (27526230)
2016
4
Simultaneous maxillo-mandibular distraction in early adolescence as a single treatment modality for durable correction of type II unilateral hemifacial microsomia: Follow-up till completion of growth. (27499513)
2016
5
Cleft characteristics and treatment outcomes in hemifacial microsomia compared to non-syndromic cleft lip/palate. (26775633)
2016
6
Relationship Between Mandibular Ramus Height and Masticatory Muscle Function in Patients With Unilateral Hemifacial Microsomia. (26752018)
2016
7
Parental Stress in Parents of a Child With Hemifacial Microsomia: The Role of Child Characteristics and Parental Coping Strategies. (27632763)
2016
8
Installing an original sleeve for rod unaccessible pain from a distraction device in a hemifacial microsomia patient. (26073915)
2015
9
The influence of gender and laterality on the incidence of hemifacial microsomia. (25723655)
2015
10
Three-dimensional functional unit analysis of hemifacial microsomia mandible-a preliminary report. (26413495)
2015
11
Hemifacial microsomia and lung hypoplasia. (25946776)
2015
12
Sequential treatment for a patient with hemifacial microsomia: 10 year-long term follow up. (25664313)
2015
13
A Child with Lung Hypoplasia, Congenital Heart Disease, Hemifacial Microsomia, and Inguinal Hernia: Ipsilateral Congenital Malformations. (26294998)
2015
14
Cranial base deviation in hemifacial microsomia by craniometric analysis. (25569421)
2015
15
Precise positioning of an intraoral distractor using augmented reality in patients with hemifacial microsomia. (25465484)
2015
16
Mandibular deformity in hemifacial microsomia: a reassessment of the Pruzansky and Kaban classification. (25357063)
2014
17
Onlay bone grafting simultaneous with facial soft tissue augmentation in a hemifacial microsomia patient using de-epithelialized orthograde submental flap: a technical note. (24753799)
2014
18
Reply: mandibular deformity in hemifacial microsomia: a reassessment of the Pruzansky and Kaban classification. (25357064)
2014
19
Development of a morphing technique for predicting the position and size of an artificial ear in hemifacial microsomia patients. (25191888)
2014
20
Three-dimensional longitudinal changes in craniofacial growth in untreated hemifacial microsomia patients with cone-beam computed tomography. (24785922)
2014
21
Maxillary involvement in hemifacial microsomia: an objective three-dimensional analysis of the craniofacial skeleton. (25006903)
2014
22
Cephalometric outcomes of orthognathic surgery in hemifacial microsomia. (25203574)
2014
23
Cephalometric Outcomes of Orthognathic Surgery in Hemifacial Microsomia. (25072970)
2014
24
Frey's syndrome following total ear reconstruction in hemifacial microsomia. (24909627)
2014
25
OTX2 duplication is implicated in hemifacial microsomia. (24816892)
2014
26
Hemifacial microsomia in cat-eye syndrome: 22q11.1-q11.21 as candidate loci for facial symmetry. (23794175)
2013
27
A de novo 1.38 Mb duplication of 1q31.1 in a boy with hemifacial microsomia, anophthalmia, anotia, macrostomia, and cleft lip and palate. (23312528)
2013
28
A fetus with hemifacial microsomia and sirenomelia. The same mesodermal defect spectrum? (22643051)
2013
29
Mandibular volumetric comparison of treacher collins syndrome and hemifacial microsomia. (22456406)
2012
30
Isolated microtia as a marker for unsuspected hemifacial microsomia. (17938322)
2007
31
A family with features overlapping Okihiro syndrome, hemifacial microsomia and isolated Duane anomaly caused by a novel SALL4 mutation. (16411190)
2006
32
Prenatal diagnosis of hemifacial microsomia and ipsilateral cerebellar hypoplasia in a fetus with oculoauriculovertebral spectrum. (15287060)
2004
33
An optic nerve hypoplasia and coloboma in a patient with hemifacial microsomia. (15305536)
2004
34
Femoral-facial syndrome with hemifacial microsomia and hypoglossia. (15127766)
2004
35
Sliding type hernia and ectopic pancreatic tissue in the stomach with renal agenesis and ear abnormalities: branchio-oto-renal syndrome or hemifacial microsomia with additional findings. (12884440)
2003
36
Neurovascular free-muscle transfer to treat facial paralysis associated with hemifacial microsomia. (11964969)
2002
37
Townes-Brocks syndrome versus expanded spectrum hemifacial microsomia: review of eight patients and further evidence of a "hot spot" for mutation in the SALL1 gene. (11478532)
2001
38
Fibrous ankylosis after distraction osteogenesis of a costochondral neomandible in a patient with grade III hemifacial microsomia. (11572253)
2001
39
A patient with VACTERL association, amelia and hemifacial microsomia. (10319203)
1999
40
Hemifacial microsomia in a newborn with hypoplastic skin lesions, an eyelid skin tag, and microphthalmia: an unusual presentation of Delleman syndrome. (9823495)
1998
41
Facial asymmetries in hemifacial microsomia, Goldenhar syndrome, and Treacher Collins syndrome. (11873461)
1996
42
Interrelationships of the hemifacial microsomia-VATER, VATER, and sirenomelia phenotypes. (8368258)
1993
43
Association between "plagiocephaly" and hemifacial microsomia. (8291557)
1993
44
Mandibulofacial dysostosis or bilateral hemifacial microsomia with hearing loss, telecanthus, tetramelic postaxial hexadactyly, congenital hypotonia and lymphedema with joint hypermobility, and pigmentary dysplasia: a new syndrome? (2556918)
1989
45
Dysmorphogenesis of the mandible, zygoma, and middle ear ossicles in hemifacial microsomia and mandibulofacial dysostosis. (2705480)
1989
46
Microtia: a microform of hemifacial microsomia. (4070453)
1985
47
Hemifacial microsomia associated with congenital partial gigantism. (6653913)
1983
48
A comparison of microtia and temporal bone anomalies in hemifacial microsomia and mandibulofacial dysostosis. (6929227)
1980
49
Goldenhar syndrome and hemifacial microsomia: observations on three patients. (7389743)
1980
50
Lateral facial dysplasia (first and second branchial arch syndrome, hemifacial microsomia). (1212511)
1975

Variations for Hemifacial Microsomia

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Expression for genes affiliated with Hemifacial Microsomia

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Search GEO for disease gene expression data for Hemifacial Microsomia.

Pathways for genes affiliated with Hemifacial Microsomia

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Pathways related to Hemifacial Microsomia according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.8SALL1, SALL4

GO Terms for genes affiliated with Hemifacial Microsomia

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Cellular components related to Hemifacial Microsomia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1heterochromatinGO:00007929.8SALL1, SALL4

Biological processes related to Hemifacial Microsomia according to GeneCards Suite gene sharing:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1ventricular septum developmentGO:000328110.1SALL1, SALL4
2somatic stem cell population maintenanceGO:003501910.1SALL1, SALL4
3osteoblast developmentGO:000207610.0HOXA2, SATB2
4negative regulation of osteoblast differentiationGO:00456689.8HOXA2, PTCH1
5regulation of smoothened signaling pathwayGO:00085899.8OTX2, PTCH1
6branching involved in ureteric bud morphogenesisGO:00016589.7PTCH1, SALL1
7neural tube closureGO:00018439.7PTCH1, SALL4
8palate developmentGO:00600219.6FRAS1, SATB2
9dorsal/ventral pattern formationGO:00099539.3HOXA2, PTCH1
10cell fate determinationGO:00017099.3HOXA2, PTCH1
11pattern specification processGO:00073899.0ALX3, HOXA2, PTCH1
12embryonic skeletal system morphogenesisGO:00487049.0ALX3, HOXA2, SATB2
13embryonic limb morphogenesisGO:00303269.0FRAS1, PTCH1, SALL4
14positive regulation of transcription from RNA polymerase II promoterGO:00459448.4HOXA2, OTX2, SALL1, SALL4, SATB2
15negative regulation of transcription from RNA polymerase II promoterGO:00001227.7HOXA2, PTCH1, SALL1, SALL4, SATB2

Molecular functions related to Hemifacial Microsomia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II core promoter proximal region sequence-specific DNA bindingGO:00009789.4HOXA2, OTX2, SALL1
2sequence-specific DNA bindingGO:00435658.3ALX3, HOXA2, SALL1, SALL4, SATB2

Sources for Hemifacial Microsomia

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet