MCID: HMF004
MIFTS: 41

Hemifacial Spasm

Categories: Rare diseases, Neuronal diseases, Genetic diseases

Aliases & Classifications for Hemifacial Spasm

MalaCards integrated aliases for Hemifacial Spasm:

Name: Hemifacial Spasm 50 28

Classifications:



Summaries for Hemifacial Spasm

NINDS : 50 Hemifacial spasm is a neuromuscular disorder characterized by frequent involuntary contractions (spasms) of the muscles on one side (hemi-) of the face (facial). The disorder occurs in both men and women, although it more frequently affects middle-aged or elderly women. It is much more common in the Asian population.  The first symptom is usually an intermittent twitching of the eyelid muscle that can lead to forced closure of the eye. The spasm may then gradually spread to involve the muscles of the lower face, which may cause the mouth to be pulled to one side. Eventually the spasms involve all of the muscles on one side of the face almost continuously. The condition may be caused by a facial nerve injury, or a tumor, or it may have no apparent cause. Rarely, doctors see individuals with spasm on both sides of the face.  Most often hemifacial spasm is caused by a blood vessel pressing on the facial nerve at the place where it exits the brainstem.

MalaCards based summary : Hemifacial Spasm is related to hemangioma and hemifacial spasm, familial. An important gene associated with Hemifacial Spasm is FLT4 (Fms Related Tyrosine Kinase 4), and among its related pathways/superpathways are PI3K-Akt signaling pathway and VEGF Pathway (Qiagen). The drugs Acetylcholine and abobotulinumtoxinA have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and brain.

Wikipedia : 72 Hemifacial spasm (HFS) is a rare neuromuscular disease characterized by irregular, involuntary muscle... more...

Related Diseases for Hemifacial Spasm

Diseases in the Hemifacial Spasm family:

Hemifacial Spasm, Familial

Diseases related to Hemifacial Spasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 136)
# Related Disease Score Top Affiliating Genes
1 hemangioma 29.6 FLT4 VEGFA
2 hemifacial spasm, familial 12.6
3 blepharospasm 10.7
4 trigeminal neuralgia 10.5
5 dystonia 10.4
6 aneurysm 10.4
7 blepharospasm, benign essential 10.3
8 glossopharyngeal neuralgia 10.3
9 meningioma, familial 10.3
10 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.3
11 focal dystonia 10.2
12 capillary hemangioma 10.2 FLT4 VEGFA
13 hydrocele 10.2 FLT4 VEGFA
14 lymphangiosarcoma 10.2 FLT4 VEGFA
15 lymphangioma 10.2 FLT4 VEGFA
16 torticollis 10.1
17 cervical dystonia 10.1
18 cervicitis 10.1
19 lipomatosis, multiple 10.1
20 vascular cancer 10.1 FLT4 VEGFA
21 retinal vascular occlusion 10.1 MTHFR VEGFA
22 breast carcinoma in situ 10.1 FLT4 VEGFA
23 central retinal vein occlusion 10.1 MTHFR VEGFA
24 seizures, benign familial neonatal, 1 10.1
25 headache 10.1
26 astrocytoma 10.1
27 migraine with or without aura 1 10.1
28 angiosarcoma 10.1 FLT4 VEGFA
29 retinal vein occlusion 10.1 MTHFR VEGFA
30 chronic myocardial ischemia 10.1 NOS3 VEGFA
31 osteonecrosis 10.1 MTHFR VEGFA
32 chronic mountain sickness 10.1 NOS3 VEGFA
33 buerger disease 10.0 MTHFR NOS3
34 ischemic heart disease 10.0 MTHFR NOS3
35 aging 10.0
36 central nervous system origin vertigo 10.0
37 arachnoiditis 10.0
38 cerebellopontine angle tumor 10.0
39 lymphedema, hereditary, ii 10.0
40 intracranial hypertension 10.0
41 tremor 10.0
42 bell's palsy 10.0
43 arachnoid cysts 10.0
44 retinal vascular disease 10.0 MTHFR VEGFA
45 arteritic anterior ischemic optic neuropathy 10.0 MTHFR NOS3
46 hepatic vascular disease 10.0 MTHFR NOS3
47 diabetic macular edema 10.0 NOS3 VEGFA
48 acute mountain sickness 10.0 NOS3 VEGFA
49 ischemic optic neuropathy 10.0 MTHFR NOS3
50 varicose veins 10.0 MTHFR VEGFA

Graphical network of the top 20 diseases related to Hemifacial Spasm:



Diseases related to Hemifacial Spasm

Symptoms & Phenotypes for Hemifacial Spasm

Drugs & Therapeutics for Hemifacial Spasm

Drugs for Hemifacial Spasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved Phase 4,Phase 3,Phase 2 51-84-3 187
2 abobotulinumtoxinA Phase 4,Phase 3,Phase 2
3 Cholinergic Agents Phase 4,Phase 3,Phase 2
4 Neuromuscular Agents Phase 4,Phase 3,Phase 2
5 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
6 onabotulinumtoxinA Phase 4,Phase 3,Phase 2
7 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
8 Botulinum Toxins Phase 4,Phase 3,Phase 2
9 Botulinum Toxins, Type A Phase 4,Phase 3,Phase 2
10
Zinc Approved, Investigational 7440-66-6 32051 23994
11
Isoflurane Approved, Vet_approved 26675-46-7 3763
12
Propofol Approved, Investigational, Vet_approved 2078-54-8 4943
13
Desflurane Approved 57041-67-5 42113
14
Sevoflurane Approved, Vet_approved 28523-86-6 5206
15
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
16
Glucosamine Approved, Investigational, Nutraceutical 3416-24-8 439213
17 tannic acid Approved, Nutraceutical
18
Methylcobalamin Approved, Experimental, Investigational, Nutraceutical Early Phase 1 13422-55-4
19 Fibrinolytic Agents
20 Central Nervous System Depressants
21 Micronutrients
22 Trace Elements
23 Glucuronyl glucosamine glycan sulfate
24 Anesthetics
25 Anesthetics, General
26 Anesthetics, Inhalation
27 Anticoagulants
28 Hypoglycemic Agents
29 Hypolipidemic Agents
30 Antimetabolites
31 Lipid Regulating Agents
32 Anesthetics, Local
33 Zinc Supplement Nutraceutical

Interventional clinical trials:

(show all 19)

# Name Status NCT ID Phase Drugs
1 Post Marketing Surveillance Study of Dysport Completed NCT00210431 Phase 4
2 Frontalis Botulinum Toxin Not yet recruiting NCT03186001 Phase 4 Abobotulinum toxin A
3 Assessment of Effectiveness and Safety of Dysport® for the Treatment of Hemifacial Spasm Completed NCT00276315 Phase 3 Botulinum type A toxin (Dysport®) - one single injection
4 Effect on Tear Functions of Pretarsal and Preseptal Techniques of Botulinum Toxin Type A Injection in Hemifacial Spasm Unknown status NCT01564979 Phase 2 preseptal injection of botulinum toxin type A;pretarsal injection of Botulinum toxin type A
5 Hemifacial Spasm and Desflurane Unknown status NCT01726725 desflurane
6 Observe Abnormal Potential From the Offending Vessel to the Facial Muscles of HFS Patients Unknown status NCT01271634
7 Testing the Effect of Zinc Supplementation to Improve the Treatment Effect of Botulinum Toxin for Oculofacial Spasm Unknown status NCT01546805 Zinc Supplement;Sugar pill
8 Effect of Hemifacial Spasm on Intraocular Pressure Measurement Completed NCT03390803
9 A Multicenter, Observational Study to Evaluate Clinical Manifestation, Diagnosis and Treatment of Primary Hemifacial Spasm in Chinese Patients Completed NCT01728428
10 Movement Disorder Survey in East China Completed NCT01168388
11 Determination of Target of Adequate Partial Neuromuscular Blockade for Electrophysiologic Monitoring During Microvascular Decompression Surgery Completed NCT01613781
12 Determination of Target of Adequate Partial Neuromuscular Blockade for Electrophysiologic Monitoring During Microvascular Decompression Surgery Completed NCT01598961
13 Botulinum Toxin A in the Treatment of Hemifacial Spasm Recruiting NCT03306940 Botulinum Toxin Type A
14 Effect of Acupuncture on Inflammation and Immune Function After Craniotomy Recruiting NCT02761096
15 Blepharospasm Tools Recruiting NCT02780336
16 An RCT of a Patient-initiated Treatment Service for BEB and HFS Active, not recruiting NCT02577224
17 Autologous Adipose Mesenchymal Stem Cell Transplantation in the Treatment of Patients With Hemifacial Spasm Not yet recruiting NCT02853942 Early Phase 1 Mecobalamin
18 Diagnostic Test of Choice for HELPS Syndrome Not yet recruiting NCT03126955
19 CSF Leak Following Microvascular Decompression: the Benefit of Routine Postoperative Lumbar Tap Withdrawn NCT01932255

Search NIH Clinical Center for Hemifacial Spasm

Genetic Tests for Hemifacial Spasm

Genetic tests related to Hemifacial Spasm:

# Genetic test Affiliating Genes
1 Hemifacial Spasm 28

Anatomical Context for Hemifacial Spasm

MalaCards organs/tissues related to Hemifacial Spasm:

38
Eye, Testes, Brain, Bone, Caudate Nucleus, Thalamus

Publications for Hemifacial Spasm

Articles related to Hemifacial Spasm:

(show top 50) (show all 670)
# Title Authors Year
1
How I do it: endoscopic microvascular decompression for hemifacial spasm associated with the vertebral artery. ( 29143107 )
2018
2
The critical warning sign of real-time brainstem auditory evoked potentials during microvascular decompression for hemifacial spasm. ( 29342440 )
2018
3
What Should We Do for Those Hemifacial Spasm Patients Without Efficacy Following Microvascular Decompression: Expectation of Delayed Relief or Early Reoperation? ( 29191535 )
2018
4
Reorganization of sensory input at brainstem in hemifacial spasm and postparalytic facial syndrome. ( 29124438 )
2018
5
Microvascular Decompression for Hemifacial Spasm. ( 29239883 )
2018
6
Isolated hemifacial spasm presenting as unilateral, involuntary ear movements. ( 29329937 )
2018
7
Blepharospasm and Hemifacial Spasm. ( 29239872 )
2018
8
Long-Term Efficacy of Initial Microvascular Decompression Versus Subsequent Microvascular Decompression for Idiopathic Hemifacial Spasm. ( 29074421 )
2018
9
Facial Myokymia and Hemifacial Spasm in Multiple Sclerosis: A Descriptive Study on Clinical Features and Treatment Outcomes. ( 29266036 )
2018
10
Neurological Imaging for Hemifacial Spasm. ( 29239882 )
2018
11
Intraoperative monitoring of Z-L response (ZLR) and abnormal muscle response (AMR) during microvascular decompression for hemifacial spasm. Interpreting the role of ZLR. ( 29344780 )
2018
12
Microvascular Decompression for Patients With Hemifacial Spasm Associated With Common Trunk Anomaly of the Cerebellar Arteries-Case Study and Review of Literature. ( 29351689 )
2018
13
Quantitative study of the correlation between cerebellar retraction factors and hearing loss following microvascular decompression for hemifacial spasm. ( 29075904 )
2018
14
Long-Term Outcome of Repeat Microvascular Decompression for Hemifacial Spasm. ( 29203317 )
2018
15
Surgical Myectomy for Essential Blepharospasm and Hemifacial Spasm. ( 29239878 )
2018
16
Efficacy of Biomedical Glue Sling Technique Versus Traditional Technique for Microvascular Decompression for Hemifacial Spasm with Refractory Hypertension. ( 29146437 )
2018
17
Botulinum Toxins for Treating Essential Blepharospasm and Hemifacial Spasm. ( 29239877 )
2018
18
Results of Atypical Hemifacial Spasm with Microvascular Decompression: 14 Case Reports and Literature Review. ( 28619495 )
2017
19
Nonspastic hemifacial spasm confirmed by abnormal muscle responses. ( 28695043 )
2017
20
Evaluating the effects of Botulinum Toxin A on tear metrics in patients with hemifacial spasm. ( 28627956 )
2017
21
Microvascular decompression for hemifacial spasm: can intraoperative lateral spread response monitoring improve surgical efficacy? ( 28498061 )
2017
22
Tenth case of bilateral hemifacial spasm treated by microvascular decompression: Review of the pathophysiology. ( 29026661 )
2017
23
Teaching Video Neuro<i>Images</i>: Hemifacial spasm due to cerebellopontine angle mass. ( 29084931 )
2017
24
Improvement of quality of life in patients with hemifacial spasm after microvascular decompression: a prospective study. ( 28826863 )
2017
25
Delayed facial palsy after microvascular decompression for hemifacial spasm: friend or foe? ( 28862543 )
2017
26
Hemifacial Spasm Secondary to Parotid Pleomorphic Adenoma With Stylomastoid Foramen Extension. ( 27755360 )
2017
27
Health-related quality of life outcomes from botulinum toxin treatment in hemifacial spasm. ( 28507604 )
2017
28
Teflon granuloma after microvascular decompression for hemifacial spasm: a case report and literature review. ( 28534142 )
2017
29
Hearing outcome following microvascular decompression for hemifacial spasm: series of 1434 cases. ( 28927910 )
2017
30
The Effect of Microvascular Decompression on Hemifacial Spasm With Atherosclerosis of Vertebral Artery. ( 28749841 )
2017
31
Botulinum toxin A is effective to treat tension-type headache caused by hemifacial spasm. ( 28734794 )
2017
32
A comparative crossover study on the treatment of hemifacial spasm and blepharospasm: preseptal and pretarsal botulinum toxin injection techniques. ( 28884242 )
2017
33
Treatment of Blepharospasm/Hemifacial Spasm. ( 28965229 )
2017
34
Hemifacial spasm and neurovascular compression syndrome. ( 28500109 )
2017
35
The effects of combined intraoperative monitoring of abnormal muscle response and Z-L response for hemifacial spasm. ( 28882717 )
2017
36
Treatment of hemifacial spasm in patient with hemifacial atrophy using combination therapy (ultrasound therapy and TENS): a case report. ( 29123626 )
2017
37
Treatment of Posterior Inferior Cerebellar Artery Adhesion on Petrous Bone During Microvascular Decompression Procedure for Hemifacial Spasm: Technique Note. ( 28863115 )
2017
38
Surgical Treatment of Hemifacial Spasm Caused by the Compression of Internal Auditory Canal of Facial Nerve. ( 28796106 )
2017
39
Operative complications of microvascular decompression for hemifacial spasm: lessons from experience of 1548 cases. ( 28823667 )
2017
40
Lower cranial nerve palsy after the infrafloccular approach in microvascular decompression for hemifacial spasm. ( 28540133 )
2017
41
Surgical management of hemifacial spasm associated with chiari I malformation: analysis of 28 cases. ( 28823670 )
2017
42
The value of lateral spread response monitoring in predicting the clinical outcome after microvascular decompression in hemifacial spasm: a prospective study on 100 patients. ( 27053220 )
2016
43
Outcome of microvascular decompression for hemifacial spasm associated with the vertebral artery. ( 27278791 )
2016
44
Facial spasms, but not hemifacial spasm: a case report and review of literature. ( 26984806 )
2016
45
Delayed Facial Palsy After Microvascular Decompression for Hemifacial Spasm. ( 27046467 )
2016
46
Efficacy of levetiracetam in primary hemifacial spasm. ( 27460515 )
2016
47
Tentorial meningioma presenting as hemifacial spasm: An unusual clinical scenario. ( 27057238 )
2016
48
Coexistence of ocular neuromyotonia and hemifacial spasm. ( 26810424 )
2016
49
A significant correlation between delayed cure after microvascular decompression and positive response to preoperative anticonvulsant therapy in patients with hemifacial spasm. ( 27235129 )
2016
50
Facial asymmetry in patients with hemifacial spasm before and after botulinum toxin A treatment. ( 27431279 )
2016

Variations for Hemifacial Spasm

Expression for Hemifacial Spasm

Search GEO for disease gene expression data for Hemifacial Spasm.

Pathways for Hemifacial Spasm

GO Terms for Hemifacial Spasm

Biological processes related to Hemifacial Spasm according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 angiogenesis GO:0001525 9.5 FLT4 NOS3 VEGFA
2 lung development GO:0030324 9.49 NOS3 VEGFA
3 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.48 FLT4 VEGFA
4 positive regulation of endothelial cell proliferation GO:0001938 9.46 FLT4 VEGFA
5 positive regulation of endothelial cell migration GO:0010595 9.43 FLT4 VEGFA
6 positive regulation of blood vessel endothelial cell migration GO:0043536 9.4 NOS3 VEGFA
7 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.37 FLT4 VEGFA
8 tetrahydrofolate interconversion GO:0035999 9.26 MTHFR TYMS
9 tetrahydrofolate metabolic process GO:0046653 9.16 MTHFR TYMS
10 response to folic acid GO:0051593 8.96 MTHFR TYMS
11 positive regulation of protein kinase C signaling GO:0090037 8.62 FLT4 VEGFA

Molecular functions related to Hemifacial Spasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 flavin adenine dinucleotide binding GO:0050660 8.96 MTHFR NOS3
2 NADP binding GO:0050661 8.62 MTHFR NOS3

Sources for Hemifacial Spasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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