MCID: HMF004
MIFTS: 43

Hemifacial Spasm malady

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Summaries for Hemifacial Spasm

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NINDS:43 Hemifacial spasm is a neuromuscular disorder characterized by frequent involuntary contractions () of the muscles on one side () of the face (). The disorder occurs in both men and women, although it more frequently affects middle-aged or elderly women. It is much more common in the Asian population.

MalaCards based summary: Hemifacial Spasm is related to hypertension and hemangioma. An important gene associated with Hemifacial Spasm is FLT4 (fms-related tyrosine kinase 4), and among its related pathways are Signaling by VEGF and Transcription Ligand dependent activation of the ESR1 SP pathway. The compounds azd 2171 and zd6474 have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and thalamus, and related mouse phenotypes are limbs/digits/tail and liver/biliary system.

Wikipedia:65 Hemifacial spasm (HFS) is a rare neuromuscular disease characterized by irregular, involuntary muscle... more...

Aliases & Classifications for Hemifacial Spasm

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Hemifacial Spasm, Aliases & Descriptions:

Name: Hemifacial Spasm 43


Related Diseases for Hemifacial Spasm

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Graphical network of the top 20 diseases related to Hemifacial Spasm:



Diseases related to hemifacial spasm

Symptoms for Hemifacial Spasm

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Drugs & Therapeutics for Hemifacial Spasm

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Drug clinical trials:

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Search NIH Clinical Center for Hemifacial Spasm

Genetic Tests for Hemifacial Spasm

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Anatomical Context for Hemifacial Spasm

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MalaCards organs/tissues related to Hemifacial Spasm:

32
Bone, Brain, Thalamus, Caudate nucleus

Animal Models for Hemifacial Spasm or affiliated genes

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MGI Mouse Phenotypes related to Hemifacial Spasm:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.4NOS3, MTHFR, VEGFA
2MP:00053708.4VEGFA, FLT4, NOS3
3MP:00053898.1NOS3, MTHFR, FLT4, VEGFA
4MP:00053788.1NOS3, MTHFR, FLT4, VEGFA

Publications for Hemifacial Spasm

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Articles related to Hemifacial Spasm:

(show top 50)    (show all 540)
idTitleAuthorsYear
1
Microvascular decompression in patients with coexistent trigeminal neuralgia, hemifacial spasm and glossopharyngeal neuralgia. (24604137)
2014
2
Delayed dural arteriovenous fistula after microvascular decompression for hemifacial spasm. (25328659)
2014
3
Immediate disappearance of hemifacial spasm after partial removal of ponto-medullary junction anaplastic astrocytoma: case report. (25382264)
2014
4
Facial nerve palsy and hemifacial spasm. (23931790)
2013
5
Use of fillers as adjunct therapy for the treatment of lower face hemifacial spasm. (23559346)
2013
6
Hemifacial spasm and recurrent stroke due to vertebrobasilar dolichoectasia coexisting with saccular aneurysm of the basilar artery: a case report. (23546920)
2013
7
Relation between the Persistence of an Abnormal Muscle Response and the Long-Term Clinical Course after Microvascular Decompression for Hemifacial Spasm. (24305017)
2013
8
Intraoperative facial electromyography and brainstem auditory evoked potential findings in microvascular decompression for hemifacial spasm: correlation with postoperative delayed facial palsy. (22777492)
2012
9
The role of autonomic nervous system in the pathophysiology of hemifacial spasm. (22663936)
2012
10
The effect of microvascular decompression for hemifacial spasm caused by vertebrobasilar dolichoectasia. (23091664)
2012
11
Monitoring of abnormal muscle response and facial motor evoked potential during microvascular decompression for hemifacial spasm. (23226604)
2012
12
Assessment of non-motor hearing symptoms in hemifacial spasm using magnetoencephalography. (22116454)
2012
13
Hemifacial spasm due to contralateral aneurysmal compression of the facial nerve successfully treated with endovascular coil embolization: case report. (21832966)
2011
14
An analysis of failed microvascular decompression in patients with hemifacial spasm: focused on the early reoperative findings. (20949293)
2010
15
Treatment of idiopathic hemifacial spasm with radiosurgery or hypofractionated stereotactic radiotherapy: preliminary results. (20376743)
2010
16
Validation of a Chinese version of disease specific quality of life scale (HFS-36) for hemifacial spasm in Taiwan. (20034399)
2009
17
Outcome predictors, efficacy and safety of Botox and Dysport in the long-term treatment of hemifacial spasm. (19364366)
2009
18
Hemifacial spasm and pontine compression caused by a giant vertebrobasilar dolichoectasia. (19295203)
2009
19
Results of auditory brainstem response monitoring of microvascular decompression: a prospective study of 22 patients with hemifacial spasm. (19655333)
2009
20
The role of genetic factors in the development of hemifacial spasm: preliminary results. (18642643)
2008
21
Chronologic analysis of symptomatic change following microvascular decompression for hemifacial spasm: value for predicting midterm outcome. (18665406)
2008
22
Focal motor seizures mimicking hemifacial spasm. (18325823)
2008
23
Imaging in hemifacial spasm and hypertension. (17851251)
2007
24
A double-blind, randomized, crossover study of prosigne versus botox in patients with blepharospasm and hemifacial spasm. (17272968)
2007
25
Hemifacial spasm induced by trigeminal stimuli and coupled with ipsilateral migraine: a spasmodic migraine. (16919068)
2006
26
Hemifacial spasm associated with otitis media with effusion: a first reported case. (16293320)
2006
27
Post-traumatic hemifacial spasm. (16860719)
2006
28
Hemifacial spasm resulting from vertebral artery dolichoectasia. (22473144)
2005
29
Health-related quality of life in blepharospasm or hemifacial spasm. (15595940)
2005
30
Hemifacial spasm: results of treatment with low dose botulinum toxin injection. (15560699)
2004
31
Microvascular decompression for hemifacial spasm caused by the vertebral artery: a simple and effective transposition method using surgical glue. (15031085)
2004
32
Demonstration of neurovascular compression in trigeminal neuralgia and hemifacial spasm with magnetic resonance imaging: comparison with surgical findings in 60 consecutive cases. (12648904)
2003
33
Lateral spread response elicited by double stimulation in patients with hemifacial spasm. (12115973)
2002
34
Monitoring of facial evoked EMG for hemifacial spasm: a critical analysis of its prognostic value. (11437290)
2001
35
Accommodative esotropia: an unrecognized cause of hemifacial spasm in children. (11508921)
2001
36
Neuroendoscopy in microvascular decompression for trigeminal neuralgia and hemifacial spasm: technical note. (10935228)
2000
37
Use of botulinum toxin A in the treatment of hemifacial spasm and blepharospasm. (10063705)
1999
38
Unilateral glaucomatous damage in a patient with hemifacial spasm. (10420114)
1999
39
Bilateral hemifacial spasm: a report of five cases and a literature review. (10091632)
1999
40
Hemifacial spasm. (9598695)
1998
41
Computed tomographic analysis of hemifacial spasm: narrowing of the posterior fossa as a possible facilitating factor for neurovascular compression. (9153617)
1997
42
Microvascular decompression for hemifacial spasm: analysis of 266 patients at Ramathibodi Hospital. (8855618)
1996
43
Hemifacial spasm: treatment with pizotifen. (8676145)
1996
44
Hemifacial spasm: successful treatment with felbamate. (7673772)
1995
45
Recordings from the facial motonucleus in rats with signs of hemifacial spasm. (7870279)
1994
46
Hemifacial spasm in an infant due to fourth ventricular ganglioglioma. Case report. (2045898)
1991
47
Blepharospasm, hemifacial spasm and the nurse's role. (2265130)
1990
48
Hemifacial spasm and facial myokymia: electrophysiological findings. (3614256)
1987
49
Intracranial microvascular decompression for "cryptogenic" hemifacial spasm, trigeminal and glossopharyngeal neuralgia, paroxysmal vertigo and tinnitus: I. Surgical technique and results. (3733416)
1986
50
Blepharospasm, Meige syndrome, and hemifacial spasm: treatment with botulinum toxin. (4033932)
1985

Variations for Hemifacial Spasm

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Expression for genes affiliated with Hemifacial Spasm

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Expression patterns in normal tissues for genes affiliated with Hemifacial Spasm

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Pathways for genes affiliated with Hemifacial Spasm

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Pathways related to Hemifacial Spasm according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5VEGFA, FLT4
2
Show member pathways
Development Ligand dependent activation of the ESR1 AP 1 pathway60
9.4VEGFA, TYMS
3
Show member pathways
One Carbon Metabolism37
dTMP de novo biosynthesis (mitochondrial)37
tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate37
Trans-sulfuration and one carbon metabolism37
methionine salvage37
Methionine metabolism60
9.3TYMS, MTHFR
4
Show member pathways
9.3MTHFR, TYMS
59.2NOS3, FLT4
6
Show member pathways
9.2FLT4, NOS3
7
Show member pathways
9.2NOS3, FLT4
89.1VEGFA, NOS3
9
Show member pathways
Development VEGF signaling via VEGFR2 generic cascades60
9.1VEGFA, NOS3
10
Show member pathways
Angiogenesis37
9.1NOS3, VEGFA
11
Show member pathways
8.7VEGFA, FLT4, NOS3
12
Show member pathways
8.7VEGFA, FLT4, NOS3
138.7NOS3, FLT4, VEGFA
14
Show member pathways
VEGFR1 specific signals37
8.7NOS3, FLT4, VEGFA
15
Show member pathways
8.7VEGFA, FLT4, NOS3

Compounds for genes affiliated with Hemifacial Spasm

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Compounds related to Hemifacial Spasm according to GeneCards/GeneDecks:

(show top 50)    (show all 74)
idCompoundScoreTop Affiliating Genes
1azd 2171449.9FLT4, VEGFA
2zd6474449.9FLT4, VEGFA
3axitinib61 44 1111.9FLT4, VEGFA
4su5416449.9FLT4, VEGFA
5sunitinib44 50 1111.8FLT4, VEGFA
6regorafenib50 1110.8VEGFA, FLT4
7ch2h4folate449.8TYMS, MTHFR
8b vitamins449.8MTHFR, TYMS
9pemetrexed50 1110.7TYMS, MTHFR
10vinorelbine44 50 1111.7VEGFA, TYMS
115,10-Methylene-THF249.7TYMS, MTHFR
12bevacizumab50 1110.7VEGFA, MTHFR
13tetrahydrofolate449.7MTHFR, TYMS
14thiopurine449.7TYMS, MTHFR
15cetuximab44 50 1111.7VEGFA, TYMS
16topotecan44 1110.5TYMS, VEGFA
17vitamin b6449.5TYMS, MTHFR
18erlotinib44 50 1111.5TYMS, VEGFA
19perindopril44 50 1111.5NOS3, VEGFA
20candesartan44 50 28 1112.4NOS3, VEGFA
21apocynin44 6110.4VEGFA, NOS3
22carvedilol44 50 28 1112.4NOS3, VEGFA
23radicicol44 61 1111.4VEGFA, NOS3
24sildenafil28 44 50 24 1113.3VEGFA, NOS3
25dihydrofolate449.3MTHFR, TYMS
26aicar44 24 1111.3NOS3, TYMS
27capecitabine44 50 1111.3VEGFA, TYMS, MTHFR
28taxane449.3MTHFR, TYMS, VEGFA
29leucovorin44 50 1111.3TYMS, VEGFA, MTHFR
30oxaliplatin44 50 1111.3MTHFR, TYMS, VEGFA
31irinotecan44 50 1111.2VEGFA, MTHFR, TYMS
32carboplatin44 50 1111.2VEGFA, MTHFR, TYMS
33gemcitabine44 50 1111.2MTHFR, VEGFA, TYMS
34thymidylate449.2TYMS, VEGFA, MTHFR
355fluorouracil449.2TYMS, MTHFR, VEGFA
36pyridoxal 5-phosphate449.0MTHFR, TYMS
37ang ii449.0NOS3, VEGFA
38matrigel449.0FLT4, VEGFA, NOS3
39docetaxel44 50 61 1112.0TYMS, NOS3, VEGFA
40ly294002449.0FLT4, NOS3, VEGFA
41tamoxifen44 50 28 1112.0TYMS, NOS3, VEGFA
42cyclophosphamide44 50 1110.9VEGFA, MTHFR, NOS3
43folate448.9MTHFR, TYMS, NOS3
44doxorubicin44 50 1110.9NOS3, VEGFA, TYMS
45methotrexate50 44 1110.9NOS3, TYMS, MTHFR
46cisplatin44 50 61 1111.8MTHFR, VEGFA, TYMS
47paclitaxel44 50 1110.6VEGFA, TYMS, FLT4, NOS3
48vegf448.6NOS3, VEGFA, FLT4, TYMS
49fluorouracil50 119.4VEGFA, MTHFR, TYMS, NOS3
50estrogen448.4FLT4, MTHFR, NOS3, VEGFA

GO Terms for genes affiliated with Hemifacial Spasm

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Biological processes related to Hemifacial Spasm according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of protein kinase C signalingGO:0900379.7VEGFA, FLT4
2cellular response to vascular endothelial growth factor stimulusGO:0359249.7VEGFA, FLT4
3vascular endothelial growth factor receptor signaling pathwayGO:0480109.6VEGFA, FLT4
4positive regulation of endothelial cell migrationGO:0105959.6FLT4, VEGFA
5positive regulation of endothelial cell proliferationGO:0019389.6VEGFA, FLT4
6response to folic acidGO:0515939.5TYMS, MTHFR
7response to hypoxiaGO:0016669.3VEGFA, MTHFR
8positive regulation of protein phosphorylationGO:0019349.2VEGFA, FLT4
9lung developmentGO:0303249.1NOS3, VEGFA
10positive regulation of angiogenesisGO:0457669.0VEGFA, NOS3

Molecular functions related to Hemifacial Spasm according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1flavin adenine dinucleotide bindingGO:0506609.0NOS3, MTHFR
2NADP bindingGO:0506618.7NOS3, MTHFR

Products for genes affiliated with Hemifacial Spasm

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Sources for Hemifacial Spasm

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet