MCID: HMF004
MIFTS: 43

Hemifacial Spasm malady

Summaries for Hemifacial Spasm

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45NINDS, 66Wikipedia, 34MalaCards
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NINDS:45 Hemifacial spasm is a neuromuscular disorder characterized by frequent involuntary contractions () of the muscles on one side () of the face (). The disorder occurs in both men and women, although it more frequently affects middle-aged or elderly women. It is much more common in the Asian population.

MalaCards: Hemifacial Spasm is related to hypertension and hemangioma. An important gene associated with Hemifacial Spasm is FLT4 (fms-related tyrosine kinase 4), and among its related pathways are Signaling by VEGF and Transcription Ligand dependent activation of the ESR1 SP pathway. The compounds azd 2171 and zd6474 have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and thalamus, and related mouse phenotypes are limbs/digits/tail and liver/biliary system.

Wikipedia:66 Hemifacial spasm (HFS) is a rare neuromuscular disease characterized by irregular, involuntary muscle... more...

Aliases & Classifications for Hemifacial Spasm

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45NINDS
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Aliases & Descriptions:

hemifacial spasm 45


Related Diseases for Hemifacial Spasm

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Hemifacial Spasm:



Diseases related to hemifacial spasm

Symptoms for Hemifacial Spasm

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Drugs & Therapeutics for Hemifacial Spasm

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Hemifacial Spasm

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Genetic Tests for Hemifacial Spasm

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Anatomical Context for Hemifacial Spasm

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34MalaCards
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MalaCards organs/tissues related to Hemifacial Spasm:

34
Bone, Brain, Thalamus, Caudate nucleus

Animal Models for Hemifacial Spasm or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Hemifacial Spasm:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.4NOS3, MTHFR, VEGFA
2MP:00053708.4VEGFA, FLT4, NOS3
3MP:00053898.1NOS3, MTHFR, FLT4, VEGFA
4MP:00053788.1NOS3, MTHFR, FLT4, VEGFA

Publications for Hemifacial Spasm

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53PubMed
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Articles related to Hemifacial Spasm:

(show top 50)    (show all 522)
idTitleAuthorsYear
1
Facial nerve palsy and hemifacial spasm. (23931790)
2013
2
Use of fillers as adjunct therapy for the treatment of lower face hemifacial spasm. (23559346)
2013
3
Hemifacial spasm and recurrent stroke due to vertebrobasilar dolichoectasia coexisting with saccular aneurysm of the basilar artery: a case report. (23546920)
2013
4
Relation between the Persistence of an Abnormal Muscle Response and the Long-Term Clinical Course after Microvascular Decompression for Hemifacial Spasm. (24305017)
2013
5
Intraoperative facial electromyography and brainstem auditory evoked potential findings in microvascular decompression for hemifacial spasm: correlation with postoperative delayed facial palsy. (22777492)
2012
6
The role of autonomic nervous system in the pathophysiology of hemifacial spasm. (22663936)
2012
7
The effect of microvascular decompression for hemifacial spasm caused by vertebrobasilar dolichoectasia. (23091664)
2012
8
Monitoring of abnormal muscle response and facial motor evoked potential during microvascular decompression for hemifacial spasm. (23226604)
2012
9
Assessment of non-motor hearing symptoms in hemifacial spasm using magnetoencephalography. (22116454)
2012
10
Sympathetic nerves bridge the cross-transmission in hemifacial spasm. (22531749)
2012
11
Glucose hypermetabolism in the thalamus of patients with hemifacial spasm. (22344604)
2012
12
A "sling swing transposition" technique with pedicled dural flap for microvascular decompression in hemifacial spasm. (22186845)
2012
13
Hemifacial spasm due to contralateral aneurysmal compression of the facial nerve successfully treated with endovascular coil embolization: case report. (21832966)
2011
14
An analysis of failed microvascular decompression in patients with hemifacial spasm: focused on the early reoperative findings. (20949293)
2010
15
Treatment of idiopathic hemifacial spasm with radiosurgery or hypofractionated stereotactic radiotherapy: preliminary results. (20376743)
2010
16
Validation of a Chinese version of disease specific quality of life scale (HFS-36) for hemifacial spasm in Taiwan. (20034399)
2009
17
Outcome predictors, efficacy and safety of Botox and Dysport in the long-term treatment of hemifacial spasm. (19364366)
2009
18
Hemifacial spasm and pontine compression caused by a giant vertebrobasilar dolichoectasia. (19295203)
2009
19
Results of auditory brainstem response monitoring of microvascular decompression: a prospective study of 22 patients with hemifacial spasm. (19655333)
2009
20
The role of genetic factors in the development of hemifacial spasm: preliminary results. (18642643)
2008
21
Chronologic analysis of symptomatic change following microvascular decompression for hemifacial spasm: value for predicting midterm outcome. (18665406)
2008
22
Focal motor seizures mimicking hemifacial spasm. (18325823)
2008
23
Imaging in hemifacial spasm and hypertension. (17851251)
2007
24
A double-blind, randomized, crossover study of prosigne versus botox in patients with blepharospasm and hemifacial spasm. (17272968)
2007
25
Hemifacial spasm induced by trigeminal stimuli and coupled with ipsilateral migraine: a spasmodic migraine. (16919068)
2006
26
Hemifacial spasm associated with otitis media with effusion: a first reported case. (16293320)
2006
27
Post-traumatic hemifacial spasm. (16860719)
2006
28
Hemifacial spasm resulting from vertebral artery dolichoectasia. (22473144)
2005
29
Health-related quality of life in blepharospasm or hemifacial spasm. (15595940)
2005
30
Hemifacial spasm: results of treatment with low dose botulinum toxin injection. (15560699)
2004
31
Microvascular decompression for hemifacial spasm caused by the vertebral artery: a simple and effective transposition method using surgical glue. (15031085)
2004
32
Demonstration of neurovascular compression in trigeminal neuralgia and hemifacial spasm with magnetic resonance imaging: comparison with surgical findings in 60 consecutive cases. (12648904)
2003
33
Lateral spread response elicited by double stimulation in patients with hemifacial spasm. (12115973)
2002
34
Comparison of preseptal and pretarsal injections of botulinum toxin in the treatment of blepharospasm and hemifacial spasm. (11954870)
2002
35
Accommodative esotropia: an unrecognized cause of hemifacial spasm in children. (11508921)
2001
36
Neuroendoscopy in microvascular decompression for trigeminal neuralgia and hemifacial spasm: technical note. (10935228)
2000
37
Use of botulinum toxin A in the treatment of hemifacial spasm and blepharospasm. (10063705)
1999
38
Unilateral glaucomatous damage in a patient with hemifacial spasm. (10420114)
1999
39
Bilateral hemifacial spasm: a report of five cases and a literature review. (10091632)
1999
40
Hemifacial spasm. (9598695)
1998
41
Computed tomographic analysis of hemifacial spasm: narrowing of the posterior fossa as a possible facilitating factor for neurovascular compression. (9153617)
1997
42
Microvascular decompression for hemifacial spasm: analysis of 266 patients at Ramathibodi Hospital. (8855618)
1996
43
Hemifacial spasm: treatment with pizotifen. (8676145)
1996
44
Hemifacial spasm: successful treatment with felbamate. (7673772)
1995
45
Recordings from the facial motonucleus in rats with signs of hemifacial spasm. (7870279)
1994
46
Hemifacial spasm in an infant due to fourth ventricular ganglioglioma. Case report. (2045898)
1991
47
Blepharospasm, hemifacial spasm and the nurse's role. (2265130)
1990
48
Hemifacial spasm and facial myokymia: electrophysiological findings. (3614256)
1987
49
Intracranial microvascular decompression for "cryptogenic" hemifacial spasm, trigeminal and glossopharyngeal neuralgia, paroxysmal vertigo and tinnitus: I. Surgical technique and results. (3733416)
1986
50
Blepharospasm, Meige syndrome, and hemifacial spasm: treatment with botulinum toxin. (4033932)
1985

Variations for Hemifacial Spasm

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Expression for genes affiliated with Hemifacial Spasm

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hemifacial Spasm

Search GEO for disease gene expression data for Hemifacial Spasm.

Pathways for genes affiliated with Hemifacial Spasm

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51PathCards, 56Reactome, 61Thomson Reuters, 31KEGG, 39NCBI BioSystems Database, 52PharmGKB, 5Cell Signaling Technology, 62Tocris Bioscience, 58SinoBiological, 54QIAGEN
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Pathways related to Hemifacial Spasm according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5VEGFA, FLT4
2
Show member pathways
Development Ligand dependent activation of the ESR1 AP 1 pathway61
9.4VEGFA, TYMS
3
Show member pathways
One Carbon Metabolism39
dTMP de novo biosynthesis (mitochondrial)39
tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate39
Trans-sulfuration and one carbon metabolism39
methionine salvage39
Methionine metabolism61
9.3TYMS, MTHFR
4
Show member pathways
9.3MTHFR, TYMS
59.2NOS3, FLT4
6
Show member pathways
9.2FLT4, NOS3
7
Show member pathways
9.2NOS3, FLT4
89.1VEGFA, NOS3
9
Show member pathways
Development VEGF signaling via VEGFR2 generic cascades61
9.1VEGFA, NOS3
10
Show member pathways
Angiogenesis39
9.1NOS3, VEGFA
11
Show member pathways
8.7VEGFA, FLT4, NOS3
12
Show member pathways
8.7VEGFA, FLT4, NOS3
138.7NOS3, FLT4, VEGFA
14
Show member pathways
VEGFR1 specific signals39
8.7NOS3, FLT4, VEGFA
15
Show member pathways
8.7VEGFA, FLT4, NOS3

Compounds for genes affiliated with Hemifacial Spasm

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Sources:
46Novoseek, 62Tocris Bioscience, 12DrugBank, 52PharmGKB, 25HMDB, 30IUPHAR
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Compounds related to Hemifacial Spasm according to GeneCards/GeneDecks:

(show top 50)    (show all 74)
idCompoundScoreTop Affiliating Genes
1azd 2171469.9VEGFA, FLT4
2zd6474469.9FLT4, VEGFA
3axitinib62 46 1211.9FLT4, VEGFA
4su5416469.9VEGFA, FLT4
5sunitinib46 52 1211.8FLT4, VEGFA
6regorafenib52 1210.8VEGFA, FLT4
7ch2h4folate469.8TYMS, MTHFR
85,10-Methylene-THF259.8TYMS, MTHFR
9pemetrexed52 1210.7TYMS, MTHFR
10vinorelbine46 52 1211.7TYMS, VEGFA
11b vitamins469.7TYMS, MTHFR
12bevacizumab52 1210.7MTHFR, VEGFA
13tetrahydrofolate469.7TYMS, MTHFR
14thiopurine469.7MTHFR, TYMS
15cetuximab46 52 1211.7VEGFA, TYMS
16erlotinib46 52 1211.5VEGFA, TYMS
17vitamin b6469.5MTHFR, TYMS
18topotecan46 1210.5VEGFA, TYMS
19perindopril46 52 1211.5NOS3, VEGFA
20candesartan46 52 30 1212.4NOS3, VEGFA
21apocynin46 6210.4NOS3, VEGFA
22carvedilol46 52 30 1212.4NOS3, VEGFA
23radicicol46 62 1211.4VEGFA, NOS3
24sildenafil30 46 52 25 1213.3NOS3, VEGFA
25pyridoxal 5-phosphate469.3MTHFR, TYMS
26aicar46 25 1211.3TYMS, NOS3
27capecitabine46 52 1211.3MTHFR, VEGFA, TYMS
28taxane469.3TYMS, VEGFA, MTHFR
29leucovorin46 52 1211.3TYMS, VEGFA, MTHFR
30oxaliplatin46 52 1211.3MTHFR, VEGFA, TYMS
31irinotecan46 52 1211.2MTHFR, VEGFA, TYMS
32carboplatin46 52 1211.2MTHFR, VEGFA, TYMS
33gemcitabine46 52 1211.2TYMS, VEGFA, MTHFR
34thymidylate469.2MTHFR, VEGFA, TYMS
355fluorouracil469.2TYMS, VEGFA, MTHFR
36dihydrofolate469.0MTHFR, TYMS
37ang ii469.0NOS3, VEGFA
38matrigel469.0NOS3, FLT4, VEGFA
39docetaxel46 52 62 1212.0TYMS, VEGFA, NOS3
40ly294002469.0NOS3, FLT4, VEGFA
41tamoxifen46 52 30 1212.0TYMS, VEGFA, NOS3
42cyclophosphamide46 52 1210.9NOS3, MTHFR, VEGFA
43folate468.9TYMS, MTHFR, NOS3
44doxorubicin46 52 1210.9TYMS, VEGFA, NOS3
45methotrexate52 46 1210.9TYMS, MTHFR, NOS3
46cisplatin46 52 62 1211.8TYMS, VEGFA, MTHFR
47paclitaxel46 52 1210.6NOS3, FLT4, VEGFA, TYMS
48vegf468.6TYMS, VEGFA, FLT4, NOS3
49fluorouracil52 129.4NOS3, MTHFR, VEGFA, TYMS
50estrogen468.4NOS3, MTHFR, FLT4, VEGFA

GO Terms for genes affiliated with Hemifacial Spasm

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17Gene Ontology
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Biological processes related to Hemifacial Spasm according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of protein kinase C signalingGO:0900379.7FLT4, VEGFA
2cellular response to vascular endothelial growth factor stimulusGO:0359249.7VEGFA, FLT4
3vascular endothelial growth factor receptor signaling pathwayGO:0480109.6FLT4, VEGFA
4positive regulation of endothelial cell migrationGO:0105959.6FLT4, VEGFA
5positive regulation of endothelial cell proliferationGO:0019389.6VEGFA, FLT4
6response to folic acidGO:0515939.5MTHFR, TYMS
7response to hypoxiaGO:0016669.3MTHFR, VEGFA
8positive regulation of protein phosphorylationGO:0019349.2FLT4, VEGFA
9lung developmentGO:0303249.1NOS3, VEGFA
10positive regulation of angiogenesisGO:0457669.0NOS3, VEGFA

Molecular functions related to Hemifacial Spasm according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1flavin adenine dinucleotide bindingGO:0506609.0NOS3, MTHFR
2NADP bindingGO:0506618.7NOS3, MTHFR

Products for genes affiliated with Hemifacial Spasm

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  • Antibodies
  • Proteins
  • Lysates
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Sources for Hemifacial Spasm

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet