MCID: HMF004
MIFTS: 26

Hemifacial Spasm malady

Summaries for Hemifacial Spasm

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43NINDS, 63Wikipedia, 32MalaCards
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NINDS:43 Hemifacial spasm is a neuromuscular disorder characterized by frequent involuntary contractions () of the muscles on one side () of the face (). The disorder occurs in both men and women, although it more frequently affects middle-aged or elderly women. It is much more common in the Asian population.

MalaCards: Hemifacial Spasm is related to migraine and blepharospasm. An important gene associated with Hemifacial Spasm is FLT4 (fms-related tyrosine kinase 4), and among its related pathways are VEGF Signaling Pathway and Signaling by VEGF. The compounds azd 2171 and zd6474 have been mentioned in the context of this disorder. Related mouse phenotype reproductive system.

Wikipedia:63 Hemifacial spasm (HFS) is a rare neuromuscular disease characterized by irregular, involuntary muscle... more...

Aliases & Classifications for Hemifacial Spasm

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43NINDS
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Aliases & Descriptions:

hemifacial spasm 43


Related Diseases for Hemifacial Spasm

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Hemifacial Spasm:



Diseases related to hemifacial spasm

Clinical Features for Hemifacial Spasm

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Drugs & Therapeutics for Hemifacial Spasm

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Hemifacial Spasm

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Anatomical Context for Hemifacial Spasm

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Animal Models for Hemifacial Spasm or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Hemifacial Spasm:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053898.7VEGFA, MTHFR, FLT4

Publications for Hemifacial Spasm

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Genetic Variations for Hemifacial Spasm

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Expression for genes affiliated with Hemifacial Spasm

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hemifacial Spasm

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Pathways for genes affiliated with Hemifacial Spasm

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Sources:
49PharmGKB, 55SinoBiological, 53Reactome, 12EMD Millipore, 4Cell Signaling Technology, 37NCBI BioSystems Database, 29KEGG, 51QIAGEN
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Compounds for genes affiliated with Hemifacial Spasm

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44Novoseek, 59Tocris Bioscience, 11DrugBank, 49PharmGKB, 28IUPHAR, 24HMDB
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Compounds related to Hemifacial Spasm according to GeneCards/GeneDecks:

(show all 49)
idCompoundScoreTop Affiliating Genes
1azd 2171449.9FLT4, VEGFA
2zd6474449.9VEGFA, FLT4
3axitinib44 59 1111.9FLT4, VEGFA
4su5416449.9VEGFA, FLT4
5sunitinib44 49 1111.8FLT4, VEGFA
6vinorelbine44 1110.8TYMS, VEGFA
7cetuximab44 49 1111.7VEGFA, TYMS
8perindopril44 49 1111.7NOS3, VEGFA
9candesartan44 28 1111.7NOS3, VEGFA
10erlotinib44 49 1111.7TYMS, VEGFA
11apocynin44 5910.7NOS3, VEGFA
12carvedilol44 49 28 1112.6NOS3, VEGFA
13topotecan44 1110.6TYMS, VEGFA
14radicicol44 59 1111.6VEGFA, NOS3
15aicar44 11 2411.6TYMS, NOS3
16ch2h4folate449.6MTHFR, TYMS
17pemetrexed49 1110.6MTHFR, TYMS
18b vitamins449.5MTHFR, TYMS
19bevacizumab49 1110.5VEGFA, MTHFR
20tetrahydrofolate449.5TYMS, MTHFR
21ang ii449.5NOS3, VEGFA
22sorafenib44 49 1111.5FLT4, VEGFA
23thiopurine449.5MTHFR, TYMS
24gefitinib44 49 1111.4TYMS, VEGFA
25paclitaxel44 49 1111.4FLT4, VEGFA, TYMS
26vitamin b6449.4TYMS, MTHFR
27dihydrofolate449.3MTHFR, TYMS
28pyridoxal 5-phosphate449.2MTHFR, TYMS
29matrigel449.2NOS3, VEGFA, FLT4
30docetaxel44 49 59 1112.2NOS3, TYMS, VEGFA
31ly294002449.2FLT4, VEGFA, NOS3
32tamoxifen44 49 28 1112.2NOS3, TYMS, VEGFA
33doxorubicin44 49 1111.1NOS3, TYMS, VEGFA
34capecitabine44 49 1111.1TYMS, VEGFA, MTHFR
35taxane449.1TYMS, VEGFA, MTHFR
36leucovorin44 49 1111.1TYMS, VEGFA, MTHFR
37oxaliplatin44 49 1111.0TYMS, VEGFA, MTHFR
38irinotecan44 49 1111.0TYMS, VEGFA, MTHFR
39carboplatin44 49 1111.0TYMS, VEGFA, MTHFR
40gemcitabine44 49 1111.0MTHFR, VEGFA, TYMS
41vitamin b12449.0TYMS, MTHFR
4215-deoxy-delta-12,14-prostaglandin j2449.0NOS3, VEGFA
43thymidylate449.0TYMS, VEGFA, MTHFR
445fluorouracil449.0TYMS, VEGFA, MTHFR
45fluorouracil49 1110.0MTHFR, TYMS, NOS3
46folate448.9NOS3, TYMS, MTHFR
47methotrexate44 49 1110.9MTHFR, TYMS, NOS3
48vegf448.7FLT4, VEGFA, TYMS, NOS3
49cisplatin44 49 59 1111.7TYMS, VEGFA, MTHFR

GO Terms for genes affiliated with Hemifacial Spasm

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16Gene Ontology
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Biological processes related to Hemifacial Spasm according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of protein kinase C signaling cascadeGO:0900379.7VEGFA, FLT4
2cellular response to vascular endothelial growth factor stimulusGO:0359249.6VEGFA, FLT4
3vascular endothelial growth factor receptor signaling pathwayGO:0480109.6VEGFA, FLT4
4positive regulation of endothelial cell migrationGO:0105959.6VEGFA, FLT4
5positive regulation of endothelial cell proliferationGO:0019389.5FLT4, VEGFA
6positive regulation of protein phosphorylationGO:0019349.5VEGFA, FLT4
7lung developmentGO:0303249.2NOS3, VEGFA
8positive regulation of angiogenesisGO:0457669.0NOS3, VEGFA

Products for genes affiliated with Hemifacial Spasm

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  • Antibodies
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Sources for Hemifacial Spasm

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet