MCID: HMF004
MIFTS: 39

Hemifacial Spasm malady

Categories: Neuronal diseases, Rare diseases, Genetic diseases

Aliases & Classifications for Hemifacial Spasm

Aliases & Descriptions for Hemifacial Spasm:

Name: Hemifacial Spasm 51 29

Classifications:



Summaries for Hemifacial Spasm

NINDS : 51 Hemifacial spasm is a neuromuscular disorder characterized by frequent involuntary contractions (spasms) of the muscles on one side (hemi-) of the face (facial). The disorder occurs in both men and women, although it more frequently affects middle-aged or elderly women. It is much more common in the Asian population.  The first symptom is usually an intermittent twitching of the eyelid muscle that can lead to forced closure of the eye. The spasm may then gradually spread to involve the muscles of the lower face, which may cause the mouth to be pulled to one side. Eventually the spasms involve all of the muscles on one side of the face almost continuously. The condition may be caused by a facial nerve injury, or a tumor, or it may have no apparent cause. Rarely, doctors see individuals with spasm on both sides of the face.  Most often hemifacial spasm is caused by a blood vessel pressing on the facial nerve at the place where it exits the brainstem.

MalaCards based summary : Hemifacial Spasm is related to focal dystonia and hemifacial spasm, familial. An important gene associated with Hemifacial Spasm is FLT4 (Fms Related Tyrosine Kinase 4), and among its related pathways/superpathways are PI3K-Akt signaling pathway and VEGF Pathway (Qiagen). The drugs Acetylcholine and Cholinergic Agents have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and bone, and related phenotype is reproductive system.

Wikipedia : 71 Hemifacial spasm (HFS) is a rare neuromuscular disease characterized by irregular, involuntary muscle... more...

Related Diseases for Hemifacial Spasm

Diseases in the Hemifacial Spasm family:

Hemifacial Spasm, Familial

Diseases related to Hemifacial Spasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 115)
id Related Disease Score Top Affiliating Genes
1 focal dystonia 30.2 NOS3 VEGFA
2 hemifacial spasm, familial 12.4
3 epidermoid brain tumor 10.9
4 blepharospasm 10.6
5 trigeminal neuralgia 10.4
6 dystonia 10.3
7 aneurysm 10.3
8 glossopharyngeal neuralgia 10.2
9 vesiculobullous skin disease 10.1 FLT4 VEGFA
10 factitious disorder 10.1 FLT4 VEGFA
11 renal adenoma 10.1 FLT4 VEGFA
12 benign familial neonatal epilepsy 10.1 FLT4 VEGFA
13 mitral valve stenosis 10.1 FLT4 VEGFA
14 cryptosporidiosis 10.1 MTHFR VEGFA
15 angular blepharoconjunctivitis 10.1 MTHFR VEGFA
16 metagonimiasis 10.1 FLT4 VEGFA
17 human granulocytic anaplasmosis 10.1 FLT4 VEGFA
18 scar contracture 10.1 MTHFR VEGFA
19 kartagener syndrome 10.1 MTHFR NOS3
20 common variable immunodeficiency 10.1 NOS3 VEGFA
21 ectodermal dysplasia 9, hair/nail type 10.1 NOS3 VEGFA
22 glutathionuria 10.1 MTHFR NOS3
23 lipoma 10.1
24 cervical dystonia 10.1
25 cervicitis 10.1
26 pancreas adenocarcinoma 10.1 MTHFR VEGFA
27 pyriform sinus cancer 10.1 NOS3 VEGFA
28 villous adenoma 10.1 MTHFR NOS3
29 vernal conjunctivitis 10.1 MTHFR VEGFA
30 alpha-2-plasmin inhibitor deficiency 10.1 MTHFR NOS3
31 zellweger syndrome 10.1 NOS3 VEGFA
32 neuropathy, hereditary sensory, type ib 10.0 MTHFR VEGFA
33 acute posterior multifocal placoid pigment epitheliopathy 10.0 NOS3 VEGFA
34 contagious pustular dermatitis 10.0 MTHFR VEGFA
35 oppositional defiant disorder 10.0 NOS3 VEGFA
36 astrocytoma 10.0
37 fiedler's myocarditis 10.0 NOS3 VEGFA
38 neurofibroma of the heart 10.0 MTHFR NOS3
39 citrullinemia, type ii, neonatal-onset 10.0 NOS3 VEGFA
40 vaginal endometrial stromal sarcoma 10.0 TYMS VEGFA
41 obstructive jaundice 10.0 MTHFR VEGFA
42 hemolytic anemia 10.0 FLT4 VEGFA
43 human venous malformation 10.0 NOS3 VEGFA
44 non-distal monosomy 10q 10.0 MTHFR VEGFA
45 arachnoiditis 10.0
46 cerebellopontine angle tumor 10.0
47 intracranial hypertension 10.0
48 bell's palsy 10.0
49 meige syndrome 10.0
50 tremor 10.0

Graphical network of the top 20 diseases related to Hemifacial Spasm:



Diseases related to Hemifacial Spasm

Symptoms & Phenotypes for Hemifacial Spasm

MGI Mouse Phenotypes related to Hemifacial Spasm:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 reproductive system MP:0005389 8.92 FLT4 MTHFR NOS3 VEGFA

Drugs & Therapeutics for Hemifacial Spasm

Drugs for Hemifacial Spasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 34)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved Phase 4,Phase 3,Phase 2 51-84-3 187
2 Cholinergic Agents Phase 4,Phase 3,Phase 2
3 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
4 abobotulinumtoxinA Phase 4,Phase 3,Phase 2
5 incobotulinumtoxinA Phase 4,Phase 3,Phase 2
6 onabotulinumtoxinA Phase 4,Phase 3,Phase 2
7 Botulinum Toxins, Type A Phase 4,Phase 3,Phase 2
8 Neuromuscular Agents Phase 3,Phase 2
9 Peripheral Nervous System Agents Phase 3,Phase 2
10 Botulinum Toxins Phase 3,Phase 2
11
Zinc Approved 7440-66-6 32051 23994
12
Isoflurane Approved, Vet_approved 26675-46-7 3763
13
Propofol Approved, Investigational, Vet_approved 2078-54-8 4943
14
Desflurane Approved 57041-67-5 42113
15
Sevoflurane Approved, Vet_approved 28523-86-6 5206
16
Benzocaine Approved 1994-09-7, 94-09-7 2337
17
Glucosamine Approved, Nutraceutical 3416-24-8 439213
18 tannic acid Approved, Nutraceutical
19 Glucuronyl glucosamine glycan sulfate
20 Trace Elements
21 Anesthetics
22 Anesthetics, General
23 Anesthetics, Inhalation
24 Hypoglycemic Agents
25 Hypolipidemic Agents
26 Fibrinolytic Agents
27 Anticoagulants
28 Lipid Regulating Agents
29 Antimetabolites
30 Micronutrients
31 Central Nervous System Depressants
32 Anesthetics, Local
33 Zinc Supplement Nutraceutical
34
Methylcobalamin Experimental, Nutraceutical Early Phase 1 13422-55-4

Interventional clinical trials:

(show all 16)
id Name Status NCT ID Phase
1 Post Marketing Surveillance Study of Dysport Completed NCT00210431 Phase 4
2 Assessment of Effectiveness and Safety of Dysport® for the Treatment of Hemifacial Spasm Completed NCT00276315 Phase 3
3 Effect on Tear Functions of Pretarsal and Preseptal Techniques of Botulinum Toxin Type A Injection in Hemifacial Spasm Unknown status NCT01564979 Phase 2
4 Hemifacial Spasm and Desflurane Unknown status NCT01726725
5 Observe Abnormal Potential From the Offending Vessel to the Facial Muscles of HFS Patients Unknown status NCT01271634
6 Testing the Effect of Zinc Supplementation to Improve the Treatment Effect of Botulinum Toxin for Oculofacial Spasm Unknown status NCT01546805
7 A Multicenter, Observational Study to Evaluate Clinical Manifestation, Diagnosis and Treatment of Primary Hemifacial Spasm in Chinese Patients Completed NCT01728428
8 Movement Disorder Survey in East China Completed NCT01168388
9 Determination of Target of Adequate Partial Neuromuscular Blockade for Electrophysiologic Monitoring During Microvascular Decompression Surgery Completed NCT01613781
10 Determination of Target of Adequate Partial Neuromuscular Blockade for Electrophysiologic Monitoring During Microvascular Decompression Surgery Completed NCT01598961
11 Effect of Acupuncture on Inflammation and Immune Function After Craniotomy Recruiting NCT02761096
12 Blepharospasm Tools Recruiting NCT02780336
13 An RCT of a Patient-initiated Treatment Service for BEB and HFS Active, not recruiting NCT02577224
14 Autologous Adipose Mesenchymal Stem Cell Transplantation in the Treatment of Patients With Hemifacial Spasm Not yet recruiting NCT02853942 Early Phase 1
15 Diagnostic Test of Choice for HELPS Syndrome Not yet recruiting NCT03126955
16 CSF Leak Following Microvascular Decompression: the Benefit of Routine Postoperative Lumbar Tap Withdrawn NCT01932255

Search NIH Clinical Center for Hemifacial Spasm

Genetic Tests for Hemifacial Spasm

Genetic tests related to Hemifacial Spasm:

id Genetic test Affiliating Genes
1 Hemifacial Spasm 29

Anatomical Context for Hemifacial Spasm

MalaCards organs/tissues related to Hemifacial Spasm:

39
Eye, Brain, Bone, Caudate Nucleus, Thalamus

Publications for Hemifacial Spasm

Articles related to Hemifacial Spasm:

(show top 50) (show all 630)
id Title Authors Year
1
Hemifacial Spasm Secondary to Parotid Pleomorphic Adenoma With Stylomastoid Foramen Extension. ( 27755360 )
2017
2
Analysis of facial motor evoked potentials for assessing a central mechanism in hemifacial spasm. ( 27177175 )
2016
3
Hemifacial spasm associated with type 1 Chiari malformation: a retrospective study of 13 cases. ( 27422274 )
2016
4
Facial spasms, but not hemifacial spasm: a case report and review of literature. ( 26984806 )
2016
5
Ephaptic transmission is the origin of the abnormal muscle response seen in hemifacial spasm. ( 27072096 )
2016
6
Erratum to: 'Effectiveness and cost-effectiveness of a patient-initiated botulinum toxin treatment model for blepharospasm and hemifacial spasm compared to standard care: study protocol for a randomised controlled trial'. ( 27439615 )
2016
7
The value of lateral spread response monitoring in predicting the clinical outcome after microvascular decompression in hemifacial spasm: a prospective study on 100 patients. ( 27053220 )
2016
8
Imaging of Neurovascular Compression Syndromes: Trigeminal Neuralgia, Hemifacial Spasm, Vestibular Paroxysmia, and Glossopharyngeal Neuralgia. ( 26892985 )
2016
9
Five-Year Retrospective Review of Cases with Benign Essential Blepharospasm and Hemifacial Spasm Presenting in a Tertiary Eye Care Center in North India. ( 27078720 )
2016
10
A Rare Cause of Hemifacial Spasm: Papillary Oncocytic Cystadenoma. ( 27761290 )
2016
11
A significant correlation between delayed cure after microvascular decompression and positive response to preoperative anticonvulsant therapy in patients with hemifacial spasm. ( 27235129 )
2016
12
Vagoglossopharyngeal Neuralgia Occurred Concomitantly with Ipsilateral Hemifacial Spasm and Versive Seizure-Like Movement: A First Case Report. ( 27455832 )
2016
13
Outcome of microvascular decompression for hemifacial spasm associated with the vertebral artery. ( 27278791 )
2016
14
Botulinum Toxin Treatment of Blepharospasm, Orofacial/Oromandibular Dystonia, and Hemifacial Spasm. ( 26866500 )
2016
15
Coexistence of ocular neuromyotonia and hemifacial spasm. ( 26810424 )
2016
16
Sexual Well-Being in Patients with Blepharospasm, Spasmodic Torticollis, and Hemifacial Spasm: A Pilot Study. ( 27761118 )
2016
17
Application of electrophysiological methodsA and magnetic resonance tomographic angiography in the differentiation between hemifacial spasm and Meige syndrome. ( 26838523 )
2016
18
Delayed Facial Palsy After Microvascular Decompression for Hemifacial Spasm. ( 27046467 )
2016
19
Prognostic ability of intraoperative electromyographic monitoring during microvascular decompression for hemifacial spasm to predict lateral spread response outcome. ( 27104851 )
2016
20
Comparison of brain MRI angiography and brain MRI cisternography in patients with hemifacial spasm. ( 26908032 )
2016
21
Significance of anomalous anterior inferior cerebellar artery-posterior inferior cerebellar artery common trunk compression in microvascular decompression for hemifacial spasm. ( 27155382 )
2016
22
Bioglue-Coated Teflon Sling Technique in Microvascular Decompression for Hemifacial Spasm Involving the Vertebral Artery. ( 27651870 )
2016
23
Is hypertension a risk factor of hemifacial spasm? ( 26969561 )
2016
24
Alleviating Maneuvers for Benign Essential Blepharospasm and Hemifacial Spasm. ( 27607413 )
2016
25
Preoperative three-dimensional diagnosis of neurovascular relationships at the root exit zones during microvascular decompression for hemifacial spasm. ( 27178237 )
2016
26
Effectiveness and cost-effectiveness of a patient-initiated botulinum toxin treatment model for blepharospasm and hemifacial spasm compared to standard care: study protocol for a randomised controlled trial. ( 26961367 )
2016
27
Increasing the area and varying the dosage of Botulinum toxin a injections for effective treatment of hemifacial spasm. ( 27067535 )
2016
28
Hemifacial Spasm Associated with Contralateral Foramen Magnum Meningioma. ( 26826538 )
2016
29
Brainstem Developmental Venous Anomaly Causing Hemifacial Spasm - Case Report and Review of the Literature. ( 27133013 )
2016
30
Reply to "The origin of the abnormal muscle response seen in hemifacial spasm remains controversial". ( 27189845 )
2016
31
Long-term surgical results in microvascular decompression for hemifacial spasm: efficacy, morbidity and quality of life. ( 27214834 )
2016
32
Vascular tortuosity in relationship with hypertension and posterior fossa volume in hemifacial spasm. ( 27473840 )
2016
33
The origin of the abnormal muscle response seen in hemifacial spasm remains controversial. ( 27222310 )
2016
34
Tentorial meningioma presenting as hemifacial spasm: An unusual clinical scenario. ( 27057238 )
2016
35
Good surgical outcomes of hemifacial spasm patients with obvious facial nerve indentation and color change. ( 27184901 )
2016
36
The association between vertebrobasilar dolichoectasia and hemifacial spasm. ( 27567723 )
2016
37
Endoscopic Microvascular Decompression with Transposition for Trigeminal Neuralgia and Hemifacial Spasm: Technical Note. ( 27595274 )
2016
38
Flatness of the infratentorial space associated with hemifacial spasm. ( 27179978 )
2016
39
Facial asymmetry in patients with hemifacial spasm before and after botulinum toxin A treatment. ( 27431279 )
2016
40
Benefits of microvascular decompression on social anxiety disorder and health-related quality of life in patients with hemifacial spasm. ( 27155866 )
2016
41
Teflon Might Be a Factor Accounting for a Failed Microvascular Decompression in Hemifacial Spasm: A Technical Note. ( 27251374 )
2016
42
Efficacy of levetiracetam in primary hemifacial spasm. ( 27460515 )
2016
43
Placement of Teflon Sponges in Microvascular Decompression Procedure for Treatment of Hemifacial Spasm. ( 25798798 )
2015
44
Preoperative Evaluation of Patients with Hemifacial Spasm by Three-dimensional Time-of-Flight (3D-TOF) and Three-dimensional Constructive Interference in Steady State (3D-CISS) Sequence. ( 25795466 )
2015
45
Systematic Literature Review of AbobotulinumtoxinA in Clinical Trials for Blepharospasm and Hemifacial Spasm. ( 26566457 )
2015
46
Cerebellar retraction and hearing loss after microvascular decompression for hemifacial spasm. ( 25514867 )
2015
47
Subjective and Objective Measures in the Treatment of Hemifacial Spasm With OnabotulinumtoxinA. ( 25811161 )
2015
48
Clinical and electrophysiological studies of botulinum toxin type A to treat hemifacial spasm complicated with auricular symptoms. ( 26309655 )
2015
49
Microvascular decompression under neuroendoscopic view in hemifacial spasm: rostral-type compression and perforator-type compression. ( 25502988 )
2015
50
CPAP Therapy Improves Intractable Hemifacial Spasm. ( 26550503 )
2015

Variations for Hemifacial Spasm

Expression for Hemifacial Spasm

Search GEO for disease gene expression data for Hemifacial Spasm.

Pathways for Hemifacial Spasm

GO Terms for Hemifacial Spasm

Biological processes related to Hemifacial Spasm according to GeneCards Suite gene sharing:

(show all 11)
id Name GO ID Score Top Affiliating Genes
1 angiogenesis GO:0001525 9.54 FLT4 NOS3 VEGFA
2 positive regulation of angiogenesis GO:0045766 9.49 NOS3 VEGFA
3 lung development GO:0030324 9.48 NOS3 VEGFA
4 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.46 FLT4 VEGFA
5 positive regulation of endothelial cell proliferation GO:0001938 9.43 FLT4 VEGFA
6 positive regulation of endothelial cell migration GO:0010595 9.4 FLT4 VEGFA
7 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.32 FLT4 VEGFA
8 tetrahydrofolate interconversion GO:0035999 9.26 MTHFR TYMS
9 tetrahydrofolate metabolic process GO:0046653 9.16 MTHFR TYMS
10 response to folic acid GO:0051593 8.96 MTHFR TYMS
11 positive regulation of protein kinase C signaling GO:0090037 8.62 FLT4 VEGFA

Molecular functions related to Hemifacial Spasm according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 flavin adenine dinucleotide binding GO:0050660 8.96 MTHFR NOS3
2 NADP binding GO:0050661 8.62 MTHFR NOS3

Sources for Hemifacial Spasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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