Hemihypertrophy malady

Wikipedia: Hemihypertrophy is a condition in which one side of the body or a part of one side is larger than the...⁴⁴ more...

MalaCards: Hemihypertrophy is related to mesoblastic nephroma and congenital mesoblastic nephroma. An important gene associated with Hemihypertrophy is IH (Hemihypertrophy), and among its related pathways are Adipocytokines & Insulin Signaling and ILK Signaling. The compounds glucose and rapamycin have been mentioned in the context of this disorder. Affiliated tissues include kidney and liver, and related mouse phenotypes are hematopoietic system and liver/biliary system.

hemihypertrophy 33 32

Diseases related to hemihypertrophy by text searches and GeneDecks gene sharing:

(show top 50)    (show all 139)

id	Related Disease	Score	Top Affiliating Genes
1	mesoblastic nephroma	28.0	IGF2, WT1
2	congenital mesoblastic nephroma	27.9	IGF2, WT1
3	hepatoblastoma	26.1	AFP, H19, IGF2, INSR, CDKN1C
4	rhabdomyosarcoma	25.5	H19, TH, WT1, IGF2, INSR, CDKN1C
5	beckwith-wiedemann syndrome	24.7	CDKN1C, IGF2, SMPD1, WT1, ABCC8, TH
6	embryonal cancer	13.3	IGF2, H19
7	gestational trophoblastic tumor	13.3	CDKN1C, H19
8	abdominal wall defect	13.2	CDKN1C, AFP
9	kidney clear cell sarcoma	13.2	IGF2, WT1
10	malignant mixed mullerian tumor	13.2	AFP, H19
11	growth disorders	13.2	H19, IGF2
12	spastic paraplegia 17	13.2	H19, IGF2
13	hyperinsulinemic hypoglycemia	13.2	ABCC8, IGF2
14	congenital nephrotic syndrome finnish type	13.1	WT1, AFP
15	rhabdoid tumors	13.1	WT1, IGF2
16	hypoglycemia of infancy	13.1	ABCC8, IGF2
17	persistent hyperinsulinemic hypoglycemia of infancy	13.1	ABCC8, IGF2
18	focal segmental glomerulosclerosis	13.0	WT1, CDKN1C
19	silver-russell syndrome	13.0	H19, IGF2, CDKN1C
20	adrenocortical carcinoma	13.0	H19, IGF2, CDKN1C
21	adrenal adenoma	13.0	H19, IGF2, CDKN1C
22	wagr syndrome	13.0	IGF2, WT1, H19
23	orbit embryonal rhabdomyosarcoma	13.0	H19, WT1, IGF2
24	acinar cell carcinoma	13.0	IGF2, AFP
25	gestational trophoblastic neoplasm	13.0	CDKN1C, AFP
26	alveolar rhabdomyosarcoma	12.9	WT1, TH
27	fetal macrosomia	12.9	INSR, IGF2
28	adrenocortical tumor	12.9	H19, IGF2, CDKN1C
29	down syndrome	12.9	AFP, H19, CDKN1C
30	ketoacidosis due to scot deficiency	12.9	INSR, ABCC8
31	hernia	12.7	CDKN1C, IGF2, WT1, H19
32	peripheral primitive neuroectodermal tumor	12.7	TH, WT1, IGF2
33	gigantism	12.7	H19, WT1, IGF2, CDKN1C
34	myeloproliferative disorder	12.7	H19, WT1, IGF2
35	testicular cancer	12.7	AFP, H19, WT1
36	gangliocytoma	12.6	PTEN, TH
37	spontaneous abortion	12.6	AFP, H19, IGF2
38	seminoma	12.5	IGF2, H19, AFP
39	testicular germ cell tumor	12.5	AFP, H19, WT1, IGF2
40	leiomyosarcoma	12.5	WT1, IGF2, INSR
41	hyperinsulinism	12.4	INSR, IGF2, ABCC8
42	growth retardation with deafness and mental retardation due to igf1 deficiency	12.4	H19, IGF2, INSR, CDKN1C
43	premature ovarian failure	12.4	H19, PTEN, IGF2
44	ovarian clear cell adenocarcinoma	12.4	PTEN, WT1, AFP
45	dysgerminoma	12.4	AFP, WT1, PTEN
46	clear cell adenocarcinoma	12.3	AFP, WT1, PTEN
47	benign tumors	12.3	AFP, PTEN, CDKN1C
48	abrikosov's tumor	12.3	PTEN, WT1, AFP
49	teratoma	12.3	PTEN, H19, AFP
50	cowden disease	12.3	PTEN, AKT2

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to hemihypertrophy:

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MGI Mouse Phenotypes related to hemihypertrophy:

²⁵ (show all 16)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	10.0	IGF2
2	liver/biliary system phenotype	MP:0005370	9.6	SMPD1, H19, TH
3	respiratory system phenotype	MP:0005388	9.4	SMPD1, INSR, TH
4	renal/urinary system phenotype	MP:0005367	7.9	CDKN1C, IGF2, INSR, H19, WT1, PTEN
5	mortality/aging	MP:0010768	7.8	AFP, H19, TH, SMPD1, PTEN, CDKN1C
6	cardiovascular system phenotype	MP:0005385	7.3	IGF2, PTEN, WT1, TH, INSR, CDKN1C
7	behavior/neurological phenotype	MP:0005386	7.3	CDKN1C, TH, SMPD1, PTEN, IGF2, INSR
8	endocrine/exocrine gland phenotype	MP:0005379	INF	H19, ABCC8, , IGF2, INSR, CDKN1C
9	homeostasis/metabolism phenotype	MP:0005376	INF	SMPD1, CDKN1C, PTEN, , IGF2, WT1
10	reproductive system phenotype	MP:0005389	INF	PTEN, , INSR, WT1, AFP, CDKN1C
11	nervous system phenotype	MP:0003631	INF	INSR, PTEN, CDKN1C, H19, IGF2,
12	no phenotypic analysis	MP:0003012	INF	H19, , IGF2
13	cellular phenotype	MP:0005384	INF	INSR, IGF2, , PTEN, SMPD1, WT1
14	muscle phenotype	MP:0005369	INF	H19, WT1, PTEN, , IGF2, INSR
15	growth/size phenotype	MP:0005378	INF	, INSR, WT1, CDKN1C, IGF2, H19
16	normal phenotype	MP:0002873	INF	, PTEN, WT1, TH, H19, CDKN1C

Articles related to hemihypertrophy:

id	Title	Authors	Year	Affiliating Genes
1	Mosaic paternal uniparental isodisomy and an ABCC8 gene mutation in a patient with permanent neonatal diabetes and hemihypertrophy. (17942821)	Shield J.P.... Ellard S.	2008	ABCC8
2	WT1 expression and hemihypertrophy in congenital mesoblastic nephroma. (19011477)	Abosoudah I.... Weitzman S.	2008	WT1
3	Hypoketotic hypofattyacidaemic hypoinsulinaemic hypoglycaemia in a child with hemihypertrophy? A new syndrome. (14764948)	Hussain K.... Aynsley-Green A.	2004	INSR
4	Hepatoblastoma associated with Beckwith-Wiedemann syndrome and hemihypertrophy. (12721741)	Hamada Y.... Hioki K.	2003	AFP
5	Germline and germline mosaic PTEN mutations associated with a Proteus-like syndrome of hemihypertrophy, lower limb asymmetry, arteriovenous malformations and lipomatosis. (10749983)	Zhou X.P.... Eng C.	2000	PTEN
6	Hemihypertrophy and a poorly differentiated embryonal rhabdomyosarcoma of the pelvis. (9917751)	Samuel D.P.... DeBaun M.R.	1999	TH

Genes related to hemihypertrophy according to GeneCards:

(show all 11)

id	Symbol	Description	Score	GeneCards Section Context
1	IH	Hemihypertrophy	11.1	Disorders, Aliases & Descriptions
2	CDKN1C	cyclin-dependent kinase inhibitor 1C (p57, Kip2)	11.0
3	H19	H19, imprinted maternally expressed transcript (non-protein coding)	11.0
4	SMPD1	sphingomyelin phosphodiesterase 1, acid lysosomal	11.0
5	WT1	Wilms tumor 1	11.0	Publications
6	IGF2	insulin-like growth factor 2 (somatomedin A)	11.0
7	ABCC8	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	11.0	Publications
8	TH	tyrosine hydroxylase	11.0	Publications
9	AFP	alpha-fetoprotein	11.0	Publications
10	PTEN	phosphatase and tensin homolog	11.0	Publications
11	INSR	insulin receptor	11.0	Publications

Pathways related to hemihypertrophy according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Adipocytokines & Insulin Signaling37	10.0	INSR
2	ILK Signaling36	INF	INSR, PTEN, , IGF2
3	Glioblastoma Multiforme36	INF	PTEN, IGF2,
4	Development IGF-RI signaling10	INF	IGF2, , PTEN
5	Transcription Receptor-mediated HIF regulation10	INF	, INSR
6	Development_IGF-1 receptor signaling41	INF	, PTEN, IGF2
7	IGF1R Signaling36	INF	IGF2, , PTEN
8	Transcription_Receptor-mediated HIF regulation41	INF	INSR, PTEN,
9	p53 Mediated Apoptosis36	INF	IGF2, , PTEN

Compounds related to hemihypertrophy according to GeneDecks:

(show top 50)    (show all 59)

id	Compound	Score	Top Affiliating Genes
1	glucose32	10.5	IGF2
2	rapamycin32 42	11.4	IGF2
3	nap-232	10.1	IGF2, H19
4	apai32	10.1	IGF2, H19
5	vincristine32 34 9 9	13.0	AFP
6	ag 102432	9.8	INSR, IGF2
7	aspartate32	9.6	SMPD1, TH, ABCC8
8	azathioprine32 34 9 9	12.4	IGF2, H19, AFP
9	phosphatidylinositol32	9.4	INSR, IGF2, SMPD1
10	cytosine32 18	10.4	WT1, H19, AFP
11	etoposide32 42 9 9	12.4	PTEN, AFP
12	progestin32	9.4	INSR, IGF2, TH
13	mannose 6-phosphate32 18	10.3	INSR, SMPD1, IGF2
14	polyethylene glycol32	9.2	INSR, IGF2, AFP
15	verapamil32 34 9 18 9	13.1	IGF2, INSR, TH
16	gefitinib32 34 9 9	12.1	IGF2, PTEN, INSR
17	ibmx32	9.0	INSR, TH, IGF2
18	5-aza-2deoxycytidine32	9.0	CDKN1C, H19, IGF2, PTEN
19	butyrate32	8.9	AFP, IGF2, TH, WT1
20	actinomycin d32	8.6	INSR, IGF2, TH, AFP
21	thymidine32 18	9.6	INSR, AFP, H19, IGF2, WT1
22	zinc32 18	9.6	WT1, SMPD1, IGF2, H19, AFP
23	doxorubicin32 34 9 9	11.6	AFP, WT1, SMPD1, PTEN
24	glutamate32	8.6	TH, ABCC8, IGF2, INSR
25	chloramphenicol32 9 9	10.5	IGF2, AFP, TH, WT1, INSR
26	glutamine32	8.4	TH, INSR, AFP, WT1, IGF2
27	cholesterol32 9 18 9	11.3	ABCC8, SMPD1, CDKN1C, PTEN, AFP
28	steroid32	8.3	WT1, PTEN, IGF2, H19, AFP
29	agar32	8.2	AFP, H19, PTEN, IGF2, INSR
30	vitamin d32	8.1	IGF2, INSR, PTEN, WT1, AFP
31	arginine32	8.0	ABCC8, WT1, PTEN, IGF2, SMPD1, INSR
32	paraffin32	7.9	WT1, H19, PTEN, IGF2, TH, AFP
33	cysteine32	7.8	TH, SMPD1, PTEN, IGF2, INSR, ABCC8
34	retinoic acid32 42 18	9.8	WT1, AFP, PTEN, H19, TH, IGF2
35	h2o232	7.7	INSR, PTEN, SMPD1, TH, AFP, IGF2
36	vegf32	7.6	AFP, TH, WT1, PTEN, IGF2, INSR
37	alanine32	7.5	TH, PTEN, IGF2, INSR, AFP
38	testosterone32 9 18 9	10.2	INSR, IGF2, PTEN, ABCC8, TH, AFP
39	estrogen32	INF	INSR, , PTEN, WT1, TH, AFP
40	oligonucleotide32	INF	IGF2, WT1, SMPD1, PTEN, , AFP
41	glycogen32 18	INF	ABCC8, PTEN, , IGF2, INSR, AFP
42	paclitaxel32 34 9 9	INF	IGF2, PTEN, , AFP
43	wortmannin32 42	INF	INSR, SMPD1, , PTEN
44	threonine32	INF	INSR, AFP, WT1, PTEN,
45	cisplatin32 34 9 9	INF	PTEN, , AFP, IGF2, SMPD1
46	ly29400232	INF	, PTEN, INSR, TH, IGF2
47	tyrosine32	INF	, INSR, IGF2, PTEN, SMPD1, WT1
48	lipid32	INF	PTEN, , INSR, SMPD1, ABCC8, AFP
49	adp32 18	INF	, PTEN, SMPD1, ABCC8, INSR
50	serine32	INF	, INSR, IGF2, PTEN, SMPD1, WT1

Biological processes related to hemihypertrophy according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	heart morphogenesis	GO:003007	9.1	INSR, TH
2	heart development	GO:007507	8.8	PTEN, WT1, TH
3	positive regulation of glycogen biosynthetic process	GO:045725	INF	, IGF2, INSR
4	insulin receptor signaling pathway	GO:008286	INF	IGF2, INSR,
5	positive regulation of glucose import	GO:046326	INF	INSR,

Molecular functions related to hemihypertrophy according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	insulin-like growth factor receptor binding	GO:005159	9.5	INSR, IGF2