MCID: HMP005
MIFTS: 52

Hemiplegia malady

Rare diseases, Neuronal diseases categories

Summaries for Hemiplegia

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66Wikipedia, 34MalaCards
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Wikipedia:66 Hemiplegia /he.m?.pli?.d?i?/ is paralysis of the arm, leg, and trunk on the same side of the body.... more...

MalaCards: Hemiplegia, also known as postnatal infantile hemiplegia nos, is related to alternating hemiplegia of childhood and epilepsy syndrome. An important gene associated with Hemiplegia is ATP1A2 (ATPase, Na+/K+ transporting, alpha 2 polypeptide), and among its related pathways are Protein digestion and absorption and Hepatic ABC Transporters. The compounds lithium carbonate and digoxin have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and testes, and related mouse phenotypes are nervous system and behavior/neurological.

Aliases & Classifications for Hemiplegia

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Sources:
9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 63UMLS, 59SNOMED-CT, 28ICD9CM, 36MeSH, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

hemiplegia 9 44 11
postnatal infantile hemiplegia nos 9
infantile hemiplegia nos 9
hemiplegia, infantile 63
infantile hemiplegia 9


External Ids:

Disease Ontology9 DOID:10969
ICD9CM28 343.4
MeSH36 D006429
ICD1026 G81, G81.9

Related Diseases for Hemiplegia

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Hemiplegia:



Diseases related to hemiplegia

Symptoms for Hemiplegia

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Drugs & Therapeutics for Hemiplegia

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Hemiplegia

Drug clinical trials:

Search ClinicalTrials for Hemiplegia

Search NIH Clinical Center for Hemiplegia

Search CenterWatch for Hemiplegia

Genetic Tests for Hemiplegia

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Anatomical Context for Hemiplegia

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Sources:
34MalaCards
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MalaCards organs/tissues related to Hemiplegia:

34
Brain, Bone, Testes, Cortex, Skin, Endothelial, Liver, Kidney, Skeletal muscle, Spinal cord, Thalamus

Animal Models for Hemiplegia or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Hemiplegia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036318.2SLC2A1, SLC1A3, ATP1A2, ATP1A3
2MP:00053867.9ATP1A3, ATP1A2, SLC1A3, SLC2A1
3MP:00053767.4SLC2A1, SLC1A3, NR0B1, ATP1A2, ATP1A3

Publications for Hemiplegia

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Sources:
53PubMed
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Articles related to Hemiplegia:

(show top 50)    (show all 630)
idTitleAuthorsYear
1
Hemiconvulsion-hemiplegia-epilepsy syndrome with 1q44 microdeletion: Causal or chance association. (24214579)
2014
2
Expected for acquisition movement exercise is more effective for functional recovery than simple exercise in a rat model of hemiplegia. (24255829)
2013
3
The effect of ankle-foot orthoses on self-reported balance confidence in persons with chronic poststroke hemiplegia. (23798045)
2013
4
Diffusion tensor imaging predicts the outcome of constraint-induced movement therapy in chronic infarction patients with hemiplegia: A pilot study. (23648673)
2013
5
A multi-site study of functional outcomes following a themed approach to hand-arm bimanual intensive therapy for children with hemiplegia. (23458353)
2013
6
Remission of anosognosia for right hemiplegia and neglect after caloric vestibular stimulation. (23142813)
2013
7
Practicing a matching movement with a mirror in individuals with spastic hemiplegia. (23751296)
2013
8
Functional studies and proteomics in platelets and fibroblasts reveal a lysosomal defect with increased cathepsin-dependent apoptosis in ATP1A3 defective alternating hemiplegia of childhood. (23681173)
2013
9
A plea for consideration of the less affected hand in therapeutic approaches to hemiplegia. (22348374)
2012
10
A pilot study of contralateral homonymous muscle activity simulated electrical stimulation in chronic hemiplegia. (22571491)
2012
11
47 year-old man with HIV infection and hemiplegia. (22697382)
2012
12
A case of rheumatoid arthritis with unilateral knee synovial hypertrophy in hemiplegia. (22506248)
2012
13
Current and future interventions for glenohumeral subluxation in hemiplegia secondary to stroke. (22982832)
2012
14
Child neurology: alternating hemiplegia of childhood. (20368625)
2010
15
A rare cause of hemiplegia. (20089026)
2010
16
Functional electrical stimulation to dorsiflexors and plantar flexors during gait to improve walking in adults with chronic hemiplegia. (20434604)
2010
17
Variable stimulation patterns for poststroke hemiplegia. (19086075)
2009
18
Verbal intelligence in Neglect: the role of anosognosia for hemiplegia. (19381128)
2009
19
Fast responses to target changes are not impaired in children with spastic hemiplegia. (18987560)
2009
20
Reality monitoring in anosognosia for hemiplegia. (19195910)
2009
21
Babinski's anosognosia for hemiplegia in early twentieth-century French neurology. (20183220)
2009
22
Anosognosia for right hemiplegia from dominant anterior cerebral artery stroke. (19570175)
2009
23
Hemiplegia with dysarthria: an initial manifestation of Japanese encephalitis in a 4-year old child. (19248662)
2008
24
Motor planning in congenital hemiplegia. (17364753)
2007
25
Impairments in precision grip correlate with functional measures in adult hemiplegia. (16679058)
2006
26
Etiology of strokes and hemiplegia in children presenting at Ayub Teaching Hospital, Abbottabad. (16977817)
2006
27
Hemiconvulsion-hemiplegia-epilepsy syndrome as a presenting feature of L-2-hydroxyglutaric aciduria. (16948946)
2006
28
Alternating hemiplegia of childhood successfully treated with topiramate: 18 months of follow-up. (16401872)
2006
29
Topiramate: a new agent for patients with alternating hemiplegia of childhood. (17177149)
2006
30
Misoplegia: a review of the literature and a case without hemiplegia. (16914766)
2006
31
Alternating hemiplegia of childhood: a study of neuropsychological functioning. (15788223)
2005
32
Idiopathic infantile asymmetry and infantile hemiplegia. (15935935)
2005
33
Hemiplegia of the will and trends in stroke incidence. (15696872)
2004
34
Functional gait changes in patients with chronic lower extremity hemiplegia treated with a technology to induce movement (TIM)-type system. (15592989)
2004
35
Novel approach for spastic hemiplegia classification through the use of support vector machines. (17271714)
2004
36
Mobility and muscle strength contralateral to hemiplegia from stroke: benefit from self-training with family support. (12820789)
2003
37
Does weight-shifting exercise improve postural symmetry in sitting in people with hemiplegia? (12850944)
2003
38
Recovery from complete hemiplegia following resection of a retrocentral metastasis: the prognostic value of intraoperative cortical stimulation. (11765822)
2001
39
Alternating hemiplegia of childhood in half-sisters. (10695898)
2000
40
Is alternating hemiplegia of childhood (AHC) a variant of migraine? (11167894)
2000
41
A novel nonsense mutation in CACNA1A causes episodic ataxia and hemiplegia. (10408533)
1999
42
Acute childhood hemiplegia associated with chickenpox. (9568925)
1998
43
Congenital bilateral perisylvian polymicrogyria presenting as congenital hemiplegia. (9633745)
1998
44
Anosognosia for hemiplegia: patient retrospections. (16571488)
1996
45
Dissociation of anosognosia for hemiplegia and aphasia during left-hemisphere anesthesia. (7824138)
1995
46
Impaired afferent control in patients with spastic hemiplegia at different recovery stages: contribution to gait disorder. (8129585)
1994
47
Gait patterns in spastic hemiplegia in children and young adults. (3667656)
1987
48
Hemiplegia in homocystinuria. (3793712)
1986
49
Physical therapy in the acute care hospital and nursing home: treatment for patients with hemiplegia due to cerebrovascular accident. (103036)
1978
50
Herpes zoster ophthalmicus with contralateral hemiplegia. (303089)
1977

Variations for Hemiplegia

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Expression for genes affiliated with Hemiplegia

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hemiplegia

Search GEO for disease gene expression data for Hemiplegia.

Pathways for genes affiliated with Hemiplegia

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Sources:
51PathCards, 31KEGG, 54QIAGEN, 56Reactome, 13EMD Millipore, 39NCBI BioSystems Database
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Pathways related to Hemiplegia according to GeneCards/GeneDecks:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5ATP1A2, ATP1A3
2
Show member pathways
9.5ATP1A2, ATP1A3
39.5ATP1A3, ATP1A2
49.5ATP1A3, ATP1A2
5
Show member pathways
9.5ATP1A2, ATP1A3
6
Show member pathways
9.5ATP1A2, ATP1A3
7
Show member pathways
9.5ATP1A3, ATP1A2
89.5ATP1A2, ATP1A3
99.5ATP1A3, ATP1A2
109.5ATP1A2, ATP1A3
119.5ATP1A3, ATP1A2
129.5ATP1A2, ATP1A3
13
Show member pathways
calcium transport I39
9.5ATP1A2, ATP1A3
14
Show member pathways
9.5ATP1A2, ATP1A3
159.5ATP1A2, ATP1A3
16
Show member pathways
Synaptic Vesicle Pathway39
9.2SLC1A3, ATP1A2
179.1SLC1A3, ATP1A3
18
Show member pathways
9.0SLC2A1, ATP1A2, ATP1A3
199.0ATP1A3, ATP1A2, SLC2A1
209.0SLC2A1, ATP1A2, ATP1A3
21
Show member pathways
8.2ATP1A3, ATP1A2, SLC1A3, SLC2A1

Compounds for genes affiliated with Hemiplegia

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Sources:
62Tocris Bioscience, 46Novoseek, 52PharmGKB, 25HMDB, 12DrugBank
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Compounds related to Hemiplegia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1lithium carbonate629.7ATP1A2, ATP1A3
2digoxin46 62 52 25 1213.6ATP1A2, ATP1A3
3inositol469.1SLC1A3, SLC2A1
4gaba469.1SLC2A1, SLC1A3
5sodium46 259.8ATP1A3, ATP1A2, SLC1A3
6glutamate468.7SLC2A1, SLC1A3, ATP1A2
7cysteine468.4SLC2A1, SLC1A3, NR0B1
8glucose468.4SLC2A1, SLC1A3, ATP1A2

GO Terms for genes affiliated with Hemiplegia

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Sources:
17Gene Ontology
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Cellular components related to Hemiplegia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sodium:potassium-exchanging ATPase complexGO:0058909.6ATP1A2, ATP1A3
2caveolaGO:0059019.5SLC2A1, ATP1A2
3synapseGO:0452029.2ATP1A2, ATP1A3
4membraneGO:0160208.4NR0B1, SLC1A3, SLC2A1
5plasma membraneGO:0058868.2SLC2A1, SLC1A3, ATP1A2, ATP1A3

Biological processes related to Hemiplegia according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1ATP biosynthetic processGO:0067549.6ATP1A2, ATP1A3
2visual learningGO:0085429.5ATP1A3, ATP1A2
3ion transmembrane transportGO:0342209.5ATP1A2, ATP1A3
4adult locomotory behaviorGO:0083449.4ATP1A2, ATP1A3
5neurotransmitter uptakeGO:0015049.3SLC1A3, ATP1A2
6sodium ion transmembrane transportGO:0357259.2ATP1A2, ATP1A3
7transmembrane transportGO:0550858.3SLC2A1, SLC1A3, ATP1A2, ATP1A3

Molecular functions related to Hemiplegia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sodium:potassium-exchanging ATPase activityGO:0053919.5ATP1A2, ATP1A3

Products for genes affiliated with Hemiplegia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hemiplegia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet