MCID: HMP005
MIFTS: 53

Hemiplegia malady

Rare diseases, Neuronal diseases categories
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Summaries for Hemiplegia

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Wikipedia:65 Hemiparesis is weakness of the entire left or right side of the body. Hemiplegia is its most severe... more...

MalaCards based summary: Hemiplegia, also known as postnatal infantile hemiplegia nos, is related to alternating hemiplegia of childhood and epilepsy syndrome. An important gene associated with Hemiplegia is ATP1A2 (ATPase, Na+/K+ transporting, alpha 2 polypeptide), and among its related pathways are Protein digestion and absorption and Hepatic ABC Transporters. The compounds lithium carbonate and digoxin have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and testes, and related mouse phenotypes are nervous system and behavior/neurological.

Aliases & Classifications for Hemiplegia

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Hemiplegia, Aliases & Descriptions:

Name: Hemiplegia 8 42 10
Postnatal Infantile Hemiplegia Nos 8
Infantile Hemiplegia Nos 8
 
Hemiplegia, Infantile 62
Infantile Hemiplegia 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


External Ids:

Disease Ontology8 DOID:10969
MeSH34 D006429
ICD9CM27 343.4
ICD1025 G81, G81.9

Related Diseases for Hemiplegia

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Graphical network of the top 20 diseases related to Hemiplegia:



Diseases related to hemiplegia

Symptoms for Hemiplegia

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Drugs & Therapeutics for Hemiplegia

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Drug clinical trials:

Search ClinicalTrials for Hemiplegia

Search NIH Clinical Center for Hemiplegia

Genetic Tests for Hemiplegia

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Anatomical Context for Hemiplegia

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MalaCards organs/tissues related to Hemiplegia:

32
Brain, Bone, Testes, Cortex, Skin, Spinal cord, Skeletal muscle, Kidney, Liver, Endothelial, Thalamus

Animal Models for Hemiplegia or affiliated genes

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MGI Mouse Phenotypes related to Hemiplegia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036318.2SLC2A1, SLC1A3, ATP1A2, ATP1A3
2MP:00053867.9ATP1A3, ATP1A2, SLC1A3, SLC2A1
3MP:00053767.4SLC2A1, SLC1A3, NR0B1, ATP1A2, ATP1A3

Publications for Hemiplegia

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Articles related to Hemiplegia:

(show top 50)    (show all 665)
idTitleAuthorsYear
1
Hemiconvulsion-hemiplegia-epilepsy syndrome with 1q44 microdeletion: Causal or chance association. (24214579)
2014
2
Error-based training and emergent awareness in anosognosia for hemiplegia. (25142215)
2014
3
Hemispherectomy in adults patients with severe unilateral epilepsy and hemiplegia. (23623848)
2013
4
Expected for acquisition movement exercise is more effective for functional recovery than simple exercise in a rat model of hemiplegia. (24255829)
2013
5
The effect of ankle-foot orthoses on self-reported balance confidence in persons with chronic poststroke hemiplegia. (23798045)
2013
6
Diffusion tensor imaging predicts the outcome of constraint-induced movement therapy in chronic infarction patients with hemiplegia: A pilot study. (23648673)
2013
7
A multi-site study of functional outcomes following a themed approach to hand-arm bimanual intensive therapy for children with hemiplegia. (23458353)
2013
8
Remission of anosognosia for right hemiplegia and neglect after caloric vestibular stimulation. (23142813)
2013
9
Practicing a matching movement with a mirror in individuals with spastic hemiplegia. (23751296)
2013
10
Functional studies and proteomics in platelets and fibroblasts reveal a lysosomal defect with increased cathepsin-dependent apoptosis in ATP1A3 defective alternating hemiplegia of childhood. (23681173)
2013
11
A plea for consideration of the less affected hand in therapeutic approaches to hemiplegia. (22348374)
2012
12
A pilot study of contralateral homonymous muscle activity simulated electrical stimulation in chronic hemiplegia. (22571491)
2012
13
47 year-old man with HIV infection and hemiplegia. (22697382)
2012
14
A case of rheumatoid arthritis with unilateral knee synovial hypertrophy in hemiplegia. (22506248)
2012
15
Current and future interventions for glenohumeral subluxation in hemiplegia secondary to stroke. (22982832)
2012
16
Child neurology: alternating hemiplegia of childhood. (20368625)
2010
17
A rare cause of hemiplegia. (20089026)
2010
18
Functional electrical stimulation to dorsiflexors and plantar flexors during gait to improve walking in adults with chronic hemiplegia. (20434604)
2010
19
Variable stimulation patterns for poststroke hemiplegia. (19086075)
2009
20
Verbal intelligence in Neglect: the role of anosognosia for hemiplegia. (19381128)
2009
21
Fast responses to target changes are not impaired in children with spastic hemiplegia. (18987560)
2009
22
Reality monitoring in anosognosia for hemiplegia. (19195910)
2009
23
Babinski's anosognosia for hemiplegia in early twentieth-century French neurology. (20183220)
2009
24
Anosognosia for right hemiplegia from dominant anterior cerebral artery stroke. (19570175)
2009
25
Hemiplegia with dysarthria: an initial manifestation of Japanese encephalitis in a 4-year old child. (19248662)
2008
26
Bilateral training does not facilitate performance of copying tasks in poststroke hemiplegia. (17082503)
2006
27
Impairments in precision grip correlate with functional measures in adult hemiplegia. (16679058)
2006
28
Etiology of strokes and hemiplegia in children presenting at Ayub Teaching Hospital, Abbottabad. (16977817)
2006
29
Hemiconvulsion-hemiplegia-epilepsy syndrome as a presenting feature of L-2-hydroxyglutaric aciduria. (16948946)
2006
30
Alternating hemiplegia of childhood successfully treated with topiramate: 18 months of follow-up. (16401872)
2006
31
Topiramate: a new agent for patients with alternating hemiplegia of childhood. (17177149)
2006
32
Misoplegia: a review of the literature and a case without hemiplegia. (16914766)
2006
33
Alternating hemiplegia of childhood: a study of neuropsychological functioning. (15788223)
2005
34
Idiopathic infantile asymmetry and infantile hemiplegia. (15935935)
2005
35
Hemiplegia of the will and trends in stroke incidence. (15696872)
2004
36
Functional gait changes in patients with chronic lower extremity hemiplegia treated with a technology to induce movement (TIM)-type system. (15592989)
2004
37
Novel approach for spastic hemiplegia classification through the use of support vector machines. (17271714)
2004
38
Mobility and muscle strength contralateral to hemiplegia from stroke: benefit from self-training with family support. (12820789)
2003
39
Recovery from complete hemiplegia following resection of a retrocentral metastasis: the prognostic value of intraoperative cortical stimulation. (11765822)
2001
40
Alternating hemiplegia of childhood in half-sisters. (10695898)
2000
41
Is alternating hemiplegia of childhood (AHC) a variant of migraine? (11167894)
2000
42
A novel nonsense mutation in CACNA1A causes episodic ataxia and hemiplegia. (10408533)
1999
43
Acute childhood hemiplegia associated with chickenpox. (9568925)
1998
44
Anosognosia for hemiplegia: patient retrospections. (16571488)
1996
45
Dissociation of anosognosia for hemiplegia and aphasia during left-hemisphere anesthesia. (7824138)
1995
46
Impaired afferent control in patients with spastic hemiplegia at different recovery stages: contribution to gait disorder. (8129585)
1994
47
Gait patterns in spastic hemiplegia in children and young adults. (3667656)
1987
48
Hemiplegia in homocystinuria. (3793712)
1986
49
Physical therapy in the acute care hospital and nursing home: treatment for patients with hemiplegia due to cerebrovascular accident. (103036)
1978
50
Herpes zoster ophthalmicus with contralateral hemiplegia. (303089)
1977

Variations for Hemiplegia

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Expression for genes affiliated with Hemiplegia

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Expression patterns in normal tissues for genes affiliated with Hemiplegia

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Pathways for genes affiliated with Hemiplegia

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Pathways related to Hemiplegia according to GeneCards/GeneDecks:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5ATP1A2, ATP1A3
2
Show member pathways
9.5ATP1A2, ATP1A3
39.5ATP1A3, ATP1A2
49.5ATP1A3, ATP1A2
5
Show member pathways
9.5ATP1A2, ATP1A3
6
Show member pathways
9.5ATP1A2, ATP1A3
7
Show member pathways
9.5ATP1A3, ATP1A2
89.5ATP1A2, ATP1A3
99.5ATP1A3, ATP1A2
109.5ATP1A2, ATP1A3
119.5ATP1A3, ATP1A2
129.5ATP1A2, ATP1A3
13
Show member pathways
calcium transport I37
9.5ATP1A2, ATP1A3
14
Show member pathways
9.5ATP1A2, ATP1A3
159.5ATP1A2, ATP1A3
16
Show member pathways
Synaptic Vesicle Pathway37
9.2SLC1A3, ATP1A2
179.1SLC1A3, ATP1A3
18
Show member pathways
9.0SLC2A1, ATP1A2, ATP1A3
199.0ATP1A3, ATP1A2, SLC2A1
209.0SLC2A1, ATP1A2, ATP1A3
21
Show member pathways
8.2ATP1A3, ATP1A2, SLC1A3, SLC2A1

Compounds for genes affiliated with Hemiplegia

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Compounds related to Hemiplegia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1lithium carbonate619.7ATP1A2, ATP1A3
2digoxin44 61 50 24 1113.6ATP1A2, ATP1A3
3inositol449.1SLC1A3, SLC2A1
4gaba449.1SLC2A1, SLC1A3
5sodium44 249.8ATP1A3, ATP1A2, SLC1A3
6glutamate448.7SLC2A1, SLC1A3, ATP1A2
7cysteine448.4SLC2A1, SLC1A3, NR0B1
8glucose448.4SLC2A1, SLC1A3, ATP1A2

GO Terms for genes affiliated with Hemiplegia

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Cellular components related to Hemiplegia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sodium:potassium-exchanging ATPase complexGO:0058909.6ATP1A2, ATP1A3
2caveolaGO:0059019.5SLC2A1, ATP1A2
3synapseGO:0452029.2ATP1A2, ATP1A3
4membraneGO:0160208.4NR0B1, SLC1A3, SLC2A1
5plasma membraneGO:0058868.2SLC2A1, SLC1A3, ATP1A2, ATP1A3

Biological processes related to Hemiplegia according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1ATP biosynthetic processGO:0067549.6ATP1A2, ATP1A3
2visual learningGO:0085429.5ATP1A3, ATP1A2
3ion transmembrane transportGO:0342209.5ATP1A2, ATP1A3
4adult locomotory behaviorGO:0083449.4ATP1A2, ATP1A3
5neurotransmitter uptakeGO:0015049.3SLC1A3, ATP1A2
6sodium ion transmembrane transportGO:0357259.2ATP1A2, ATP1A3
7transmembrane transportGO:0550858.3SLC2A1, SLC1A3, ATP1A2, ATP1A3

Molecular functions related to Hemiplegia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sodium:potassium-exchanging ATPase activityGO:0053919.5ATP1A2, ATP1A3

Products for genes affiliated with Hemiplegia

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  • Antibodies
  • Proteins
  • Lysates

Sources for Hemiplegia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet