MCID: HMP005
MIFTS: 54

Hemiplegia malady

Neuronal diseases category

Summaries for Hemiplegia

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63Wikipedia, 32MalaCards
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Wikipedia:63 Hemiplegia /he.mə.pliː.dʒiə/ is paralysis of the arm, leg, and trunk on the same side of the body.... more...

MalaCards: Hemiplegia, also known as postnatal infantile hemiplegia nos, is related to alternating hemiplegia of childhood and spastic hemiplegia. An important gene associated with Hemiplegia is ATP1A2 (ATPase, Na+/K+ transporting, alpha 2 polypeptide), and among its related pathways are Sodium-coupled transporters and pumps and Bile secretion. The compounds lithium carbonate and estrogen have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and testes, and related mouse phenotypes are homeostasis/metabolism and nervous system.

Aliases & Classifications for Hemiplegia

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

hemiplegia 8 42 10
postnatal infantile hemiplegia nos 8
infantile hemiplegia nos 8
hemiplegia, infantile 60
infantile hemiplegia 8


External Ids:

Disease Ontology8 DOID:10969
MeSH34 D006429
ICD9CM27 343.4
ICD1025 G81, G81.9

Related Diseases for Hemiplegia

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Hemiplegia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 250)
idRelated DiseaseScoreTop Affiliating Genes
1alternating hemiplegia of childhood31.2ATP1A2
2spastic hemiplegia31.2HFM1, GAS7, GABARAPL1
3migraine30.3SLC1A3, CALCA, CACNA1A, ATP1A2, TAC1
4episodic ataxia30.1SLC1A3
5familial hemiplegic migraine30.1ATP1A2, CACNA1A
6hypertension29.8CALCA, MMP9, TAC1
7dementia29.6SLC1A3
8hemiplegic migraine29.6ATP1A2, CACNA1A
9meningitis29.6MMP9
10diabetes mellitus29.6SLC2A1, MMP9, CALCA, TAC1
11anosognosia10.6
12cerebritis10.5
13epilepsy syndrome10.5
14laryngitis10.4
15herpes zoster10.3
16cerebral palsy10.2
17reflex sympathetic dystrophy10.1
18encephalitis10.1
19lateral medullary syndrome10.1
20spastic cerebral palsy10.1
21alternating hemiplegia of childhood 210.1
22idiopathic hemiconvulsion-hemiplegia syndrome10.1
23spastic diplegia10.0
24quadriplegia10.0
25japanese encephalitis10.0
26aphasia10.0
27focal epilepsy10.0
28image syndrome10.0
29familial porencephaly10.0
30medial medullary syndrome10.0
31hemiplegia alterans10.0
32benign familial nocturnal alternating hemiplegia of childhood10.0
33obesity10.0NR0B1, SLC2A1
34migraine without aura10.0ATP1A2, CACNA1A
35wilms tumor10.0NR0B1
36ischemia10.0SLC1A3, ATP1A2
37epicondylitis10.0HFM1, TAC1
38neuropathy10.0TAC1, CACNA1A, CALCA
39mental retardation10.0ATP1A2, SLC1A3, CACNA1A, NR0B1
40giant cell tumor10.0CALCA
41osteosarcoma10.0SLC1A3, ACP5, MMP9
42metaphyseal dysplasia10.0NR0B1
43schizophrenia10.0SLC2A1, TAC1, CACNA1A, SLC1A3
44glioblastoma multiforme10.0SLC1A3, MMP9, TAC1, SLC2A1
45cerebral angioma9.9
46conversion disorder9.9
47cerebral artery occlusion9.9
48cadasil9.9
49homocystinuria9.9
50brown-sequard syndrome9.9

Graphical network of the top 20 diseases related to Hemiplegia:



Diseases related to hemiplegia

Clinical Features for Hemiplegia

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Drugs & Therapeutics for Hemiplegia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Hemiplegia

Search CenterWatch for Hemiplegia

Genetic Tests for Hemiplegia

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Anatomical Context for Hemiplegia

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32MalaCards
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MalaCards organs/tissues related to Hemiplegia:

32
Brain, Bone, Testes, Cortex, Skin, Endothelial, Liver, Kidney, Skeletal muscle, Spinal cord, Thalamus

Animal Models for Hemiplegia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Hemiplegia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.0CALCA, CACNA1A, FEV, ATP1A3, ATP1A2, NR0B1
2MP:00036318.9SLC1A3, C1QTNF5, COL4A2, CALCA, CACNA1A, FEV
3MP:00053868.8CALCA, CACNA1A, FEV, ATP1A3, ATP1A2, TAC1

Publications for Hemiplegia

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Sources:
50PubMed
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Articles related to Hemiplegia:

(show top 50)    (show all 641)
idTitleAuthorsYear
1
Motion of the center of mass in children with spastic hemiplegia: balance, energy transfer, and work performed by the affected leg vs. the unaffected leg. (24119778)
2014
2
The effect of ankle-foot orthoses on self-reported balance confidence in persons with chronic poststroke hemiplegia. (23798045)
2013
3
Evaluation of Reach and Grasp Robot-Assisted Therapy Suggests Similar Functional Recovery Patterns on Proximal and Distal Arm Segments in Sub-Acute Hemiplegia. (23744701)
2013
4
Multi-modal brain imaging showing brain damage to the orbitofrontal cortex and left hemisphere, in a case of prolonged hypoglycemia-induced transient hemiplegia followed by persistent encephalopathy. (23711198)
2013
5
Heterotopic ossification as rare complication of hemiplegia following stroke: two cases. (24088051)
2013
6
Validity and responsiveness of the German version of the Motor Activity Log for the assessment of self-perceived arm use in hemiplegia after stroke. (23949073)
2013
7
Effects of a dynamic progressive orthotic intervention for chronic hemiplegia: a case series. (23149271)
2013
8
Comparison of activities of daily living (ADLs) in two different one arm drive wheelchairs: a study of individuals/participants with hemiplegia. (24131370)
2013
9
Modified constraint-induced movement therapy versus intensive bimanual training for children with hemiplegia - a randomized controlled trial. (23818409)
2013
10
Dynamic equinus with hindfoot valgus in children with hemiplegia. (22425192)
2012
11
Late cytotoxic edema in 2 children with hemiplegia: hemiplegic migraine or stroke? (22404149)
2012
12
An 11-year follow-up study of neonatal-onset, bath-induced alternating hemiplegia of childhood in twins. (22378663)
2012
13
Contralaterally controlled functional electrical stimulation for upper extremity hemiplegia: an early-phase randomized clinical trial in subacute stroke patients. (21875892)
2012
14
Muscle releases to improve passive motion and relieve pain in patients with spastic hemiplegia and elbow flexion contractures. (22217645)
2012
15
Seeing the gaps: a systematic review of visual perception tools for children with hemiplegia. (21265609)
2011
16
Absence of small-vessel abnormalities in alternating hemiplegia of childhood. (20826074)
2011
17
Unawareness after stroke: a review and practical guide to understanding, assessing, and managing anosognosia for hemiplegia. (21936643)
2011
18
Clinical features of nine patients with alternating hemiplegia of childhood. (21449903)
2011
19
Alternating hemiplegia of childhood: successful treatment with topiramate and flunarizine, a case report. (21575320)
2011
20
Benign nocturnal alternating hemiplegia of childhood: two cases with positive evolution. (20817433)
2011
21
Anosognosia for hemiplegia as a global deficit in motor awareness: evidence from the non-paralysed limb. (20667488)
2010
22
The relationship between unimanual capacity and bimanual performance in children with congenital hemiplegia. (20132142)
2010
23
Upper limb function and brain reorganization after constraint-induced movement therapy in children with hemiplegia. (20067342)
2010
24
Gait patterns in hemiplegic children with Cerebral Palsy: comparison of right and left hemiplegia. (20674265)
2010
25
Fast responses to target changes are not impaired in children with spastic hemiplegia. (18987560)
2009
26
Anosognosia for right hemiplegia from dominant anterior cerebral artery stroke. (19570175)
2009
27
Botulinum toxin-a in children with congenital spastic hemiplegia does not improve upper extremity motor-related function over rehabilitation alone: a randomized controlled trial. (19106252)
2009
28
A novel functional electrical stimulation treatment for recovery of hand function in hemiplegia: 12-week pilot study. (18812432)
2009
29
Stage-oriented comprehensive acupuncture treatment plus rehabilitation training for apoplectic hemiplegia. (18652112)
2008
30
Phase II trial to evaluate the ActiGait implanted drop-foot stimulator in established hemiplegia. (17468789)
2007
31
A preliminary study into the criterion validity of the Modified Modified Ashworth Scale using the new measure of the alpha motoneuron excitability in spastic hemiplegia. (17557652)
2007
32
Alternating hemiplegia of childhood: a study of neuropsychological functioning. (15788223)
2005
33
General anesthesia for a patient with alternating hemiplegia of childhood. (16326684)
2005
34
Functional gait changes in patients with chronic lower extremity hemiplegia treated with a technology to induce movement (TIM)-type system. (15592989)
2004
35
Leg orthosis treatment for a patient with left parietal foot amputation and right hemiplegia. (15480950)
2004
36
Laryngeal hemiplegia in a ram associated with Sarcocystis species infection. (12877218)
2003
37
Caesarean section under general anaesthetic in a woman with alternating hemiplegia of childhood. (15321538)
2002
38
Hemiconvulsion-hemiplegia-epilepsy syndrome: characteristic early magnetic resonance imaging findings. (11913562)
2002
39
Alternating hemiplegia of childhood or Hashimoto's encephalopathy? (10201439)
1999
40
Spastic hemiplegia of the upper extremity in children. (9526161)
1998
41
Hemicorporal distribution of lepromatous leprosy in a patient with hemiplegia. (9675480)
1998
42
Hemiconvulsion-hemiplegia-epilepsy syndrome. A clinical, electroencephalographic and neuroradiological study. (9224914)
1997
43
Anosognosia for hemiplegia, neglect dyslexia, and drawing neglect: clinical findings and theoretical considerations. (9375168)
1996
44
Alternating hemiplegia of childhood. (8772847)
1996
45
Early diagnosis of spastic diplegia, spastic hemiplegia, and quadriplegia. (2816867)
1989
46
Hemiplegia in homocystinuria. (3793712)
1986
47
Cavernous sinus thrombosis with retrobulbar mass and hemiplegia. (6671735)
1983
48
Alterations in dynamic and static properties of the stretch reflex in patients with spastic hemiplegia. (5647955)
1968
49
Cerebral oedema and spastic hemiplegia following minor burns in young children. (13890107)
1962
50
Frontal osteomyelitis with subdural abscess and hemiplegia after frontal sinusitis. (21025615)
1946

Genetic Variations for Hemiplegia

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Expression for genes affiliated with Hemiplegia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hemiplegia

Search GEO for disease gene expression data for Hemiplegia.

Pathways for genes affiliated with Hemiplegia

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12EMD Millipore, 29KEGG, 37NCBI BioSystems Database
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Pathways related to Hemiplegia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2ATP1A2, ATP1A3
210.1SLC2A1, ATP1A2, ATP1A3
3
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10.1SLC2A1, ATP1A2, ATP1A3
410.1ATP1A2, ATP1A3, COL4A2
5
Hide members
10.1CACNA1A, ATP1A2, SLC1A3
69.8SLC1A3, TAC1, ATP1A3, FEV

Compounds for genes affiliated with Hemiplegia

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Sources:
59Tocris Bioscience, 44Novoseek, 28IUPHAR, 49PharmGKB, 11DrugBank, 24HMDB
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Compounds related to Hemiplegia according to GeneCards/GeneDecks:

(show all 22)
idCompoundScoreTop Affiliating Genes
1lithium carbonate5910.5ATP1A2, ATP1A3
2estrogen4410.5TAC1
3rp6758044 2811.4TAC1, CALCA
4gr 7363244 5911.4TAC1, CALCA
5helospectin4410.4TAC1, CALCA
6resiniferatoxin44 2811.4TAC1, CALCA
7digoxin44 49 59 11 2414.4ATP1A3, ATP1A2, TAC1
8guanethidine44 1111.3TAC1, CALCA
9hydroxyproline44 11 2412.3CALCA, MMP9, ACP5
10cromakalim44 2811.3TAC1, CALCA
11l-nmma4410.2ACP5, MMP9, TAC1
12prostaglandin f2alpha4410.2SLC2A1, TAC1, CALCA
13i-app4410.2TAC1, CALCA
14capsazepine44 59 2812.1TAC1, CALCA
15gaba4410.1TAC1, MMP9, SLC2A1, SLC1A3
16tartrate4410.0ACP5, CALCA
17sodium44 2411.0CACNA1A, ATP1A3, ATP1A2, TAC1, SLC1A3
18adenylate449.9SLC1A3, SLC2A1, MMP9, TAC1, CALCA
19glutamate449.7SLC1A3, CALCA, CACNA1A, ATP1A2, TAC1, MMP9
20verapamil44 49 28 11 2413.7CACNA1A, TAC1, SLC2A1
21dexamethasone44 49 28 1112.6ACP5, SLC2A1, MMP9, TAC1, NR0B1
22cysteine449.5NR0B1, TAC1, MMP9, SLC2A1, SLC1A3, ACP5

GO Terms for genes affiliated with Hemiplegia

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16Gene Ontology
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Cellular components related to Hemiplegia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sodium:potassium-exchanging ATPase complexGO:00589010.2ATP1A2, ATP1A3
2neuronal cell bodyGO:0430259.5SLC1A3, TAC1, CACNA1A, CALCA

Biological processes related to Hemiplegia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neurotransmitter uptakeGO:00150410.3SLC1A3, ATP1A2
2response to painGO:04826510.1TAC1, CALCA
3regulation of blood pressureGO:00821710.0TAC1, ATP1A2, CALCA
4elevation of cytosolic calcium ion concentrationGO:0072049.9CALCA, CACNA1A, TAC1
5response to lipopolysaccharideGO:0324969.6LY96, ACP5, TAC1

Molecular functions related to Hemiplegia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sodium:potassium-exchanging ATPase activityGO:00539110.2ATP1A2, ATP1A3

Products for genes affiliated with Hemiplegia

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Sources for Hemiplegia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet