MCID: HMP005
MIFTS: 47

Hemiplegia malady

Neuronal category

Summaries for Hemiplegia

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Hemiplegia /he.mə.pliː.dʒiə/ is paralysis of the arm, leg, and trunk on the same side of the body.... more...

MalaCards: Hemiplegia, also known as postnatal infantile hemiplegia nos, is related to spastic hemiplegia and alternating hemiplegia of childhood. An important gene associated with Hemiplegia is ATP1A2 (ATPase, Na+/K+ transporting, alpha 2 polypeptide), and among its related pathways are Sodium-coupled transporters and pumps and Bile secretion. The compounds lithium carbonate and estrogen have been mentioned in the context of this disorder. Related mouse phenotypes are homeostasis/metabolism and nervous system.

Aliases & Classifications for Hemiplegia

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 61UMLS, 57SNOMED-CT, 35MeSH, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Aliases & Descriptions:

hemiplegia 8 43 10
postnatal infantile hemiplegia nos 8
infantile hemiplegia nos 8
hemiplegia, infantile 61
infantile hemiplegia 8


External Ids:

Disease Ontology8 DOID:10969
MeSH35 D006429
ICD9CM27 343.4
ICD1025 G81, G81.9

Related Diseases for Hemiplegia

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Hemiplegia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 272)
idRelated DiseaseScoreTop Affiliating Genes
1spastic hemiplegia31.2HFM1, GAS7, GABARAPL1
2alternating hemiplegia of childhood30.7ATP1A2
3hemiplegic migraine30.3ATP1A2, CACNA1A
4episodic ataxia30.1SLC1A3
5familial hemiplegic migraine30.1ATP1A2, CACNA1A
6mental retardation29.9ATP1A2, SLC1A3, CACNA1A, NR0B1
7anosognosia10.6
8herpes zoster10.3
9n syndrome10.3
10herpes zoster ophthalmicus10.3
11reflex sympathetic dystrophy10.1
12epileptic hemiplegia10.1
13idiopathic hemiconvulsion-hemiplegia syndrome10.1
14lateral medullary syndrome10.1
15spastic cerebral palsy10.1
16familial porencephaly10.1
17spasticity10.1
18alternating hemiplegia of childhood 210.1
19spastic diplegia10.0
20quadriplegia10.0
21japanese encephalitis10.0
22horner's syndrome10.0
23aphasia10.0
24char syndrome10.0
25medial medullary syndrome10.0
26porencephaly10.0
27ataxia10.0
28brain injury10.0
29hemiplegia alterans10.0
30startle epilepsy10.0
31benign familial nocturnal alternating hemiplegia of childhood10.0
32obesity10.0NR0B1, SLC2A1
33dementia10.0SLC1A3
34migraine without aura10.0ATP1A2, CACNA1A
35wilms tumor10.0NR0B1
36ischemia10.0SLC1A3, ATP1A2
37meningitis10.0MMP9
38epicondylitis10.0HFM1, TAC1
39neuropathy10.0TAC1, CACNA1A, CALCA
40hypertension10.0CALCA, MMP9, TAC1
41giant cell tumor10.0CALCA
42osteosarcoma10.0SLC1A3, ACP5, MMP9
43migraine10.0SLC1A3, CALCA, CACNA1A, ATP1A2, TAC1
44metaphyseal dysplasia10.0NR0B1
45diabetes mellitus10.0SLC2A1, MMP9, CALCA, TAC1
46schizophrenia10.0SLC2A1, TAC1, CACNA1A, SLC1A3
47glioblastoma multiforme10.0SLC1A3, MMP9, TAC1, SLC2A1
48sneddon syndrome9.9
49cerebral angioma9.9
50conversion disorder9.9

Graphical network of the top 20 diseases related to Hemiplegia:



Diseases related to hemiplegia

Clinical Features for Hemiplegia

Drugs & Therapeutics for Hemiplegia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Hemiplegia

Drug clinical trials:

Search ClinicalTrials for Hemiplegia

Search NIH Clinical Center for Hemiplegia

Search CenterWatch for Hemiplegia

Genetic Tests for Hemiplegia

Anatomical Context for Hemiplegia

Animal Models for Hemiplegia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Hemiplegia

Sources:
51PubMed
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Articles related to Hemiplegia:

(show top 50)    (show all 641)
idTitleAuthorsYear
1
Hemiconvulsion-hemiplegia-epilepsy syndrome with 1q44 microdeletion: Causal or chance association. (24214579)
2014
2
Remission of anosognosia for right hemiplegia and neglect after caloric vestibular stimulation. (23142813)
2013
3
Cohort study examining long-term respiratory health, career duration and racing performance in racehorses that undergo left-sided prosthetic laryngoplasty and ventriculocordectomy surgery for treatment of left-sided laryngeal hemiplegia. (22812572)
2013
4
COMBIT: protocol of a randomised comparison trial of COMbined modified constraint induced movement therapy and bimanual intensive training with distributed model of standard upper limb rehabilitation in children with congenital hemiplegia. (23809257)
2013
5
Gait detection in children with and without hemiplegia using single-axis wearable gyroscopes. (24023825)
2013
6
Multilevel surgery improves gait in spastic hemiplegia but does not resolve hip dysplasia. (21984351)
2012
7
Heterozygous de-novo mutations in ATP1A3 in patients with alternating hemiplegia of childhood: a whole-exome sequencing gene-identification study. (22850527)
2012
8
Motor imagery of the unaffected hand in children with spastic hemiplegia. (22292833)
2012
9
Anosognosia for hemiplegia with preserved awareness of complete cortical blindness following intracranial hemorrhage. (21194684)
2011
10
Development of a self-contained accelerometry based system for control of functional electrical stimulation in hemiplegia. (22255570)
2011
11
Patient-centered rehabilitation, three years of gait recovery in a child affected by hemiplegia:. case report. (21304448)
2011
12
The effect of arm sling on balance in patients with hemiplegia. (20888770)
2010
13
Recovery from spatial neglect and hemiplegia in a child despite a large anterior circulation stroke and Wallerian degeneration. (19850563)
2010
14
Neonatal onset of bath-induced alternating hemiplegia of childhood. (19717320)
2010
15
An unusual cause of hemiplegia: external hydrocephalus. (19650367)
2009
16
Effect of ankle-foot orthosis alignment and foot-plate length on the gait of adults with poststroke hemiplegia. (19406301)
2009
17
Clinical reasoning: a 35-year-old man with a right hemiplegia and a cerebral mass. (19704073)
2009
18
A randomized controlled trial of an implantable 2-channel peroneal nerve stimulator on walking speed and activity in poststroke hemiplegia. (17678657)
2007
19
Improving hand function in stroke survivors: a pilot study of contralaterally controlled functional electric stimulation in chronic hemiplegia. (17398254)
2007
20
Kinematic aiming task: measuring functional changes in hand and arm movements after botulinum toxin-A injections in children with spastic hemiplegia. (17581288)
2007
21
A modified constraint-induced movement therapy regimen for individuals with upper extremity hemiplegia. (17458370)
2007
22
Impairments in precision grip correlate with functional measures in adult hemiplegia. (16679058)
2006
23
Etiology of strokes and hemiplegia in children presenting at Ayub Teaching Hospital, Abbottabad. (16977817)
2006
24
Effect of "phased whole acupuncture therapy" on ability of daily life in 63 cases of cerebral infarction-induced hemiplegia. (16817265)
2006
25
Hemiconvulsion, hemiplegia, epilepsy syndrome and inherited protein S deficiency. (16514228)
2006
26
Noradrenergic modulation of hemiplegia: facilitation and maintenance of recovery. (15502264)
2004
27
Physiotherapy for pusher behaviour in a patient with post-stroke hemiplegia. (15370735)
2004
28
Acute hemiplegia associated with cat-scratch disease. (15476060)
2004
29
Does weight-shifting exercise improve postural symmetry in sitting in people with hemiplegia? (12850944)
2003
30
Long-latency motor evoked potentials in congenital hemiplegia. (14499742)
2003
31
Gait training in hemiplegia. (11918646)
2002
32
Bilateral facilitation of motor control in chronic hemiplegia. (12102112)
2002
33
Increased frequency dependence of specific airway resistance in patients with laryngeal hemiplegia. (11829082)
2001
34
Congenital bilateral perisylvian polymicrogyria presenting as congenital hemiplegia. (9633745)
1998
35
Accelerated bone remodeling in patients with poststroke hemiplegia. (17895057)
1998
36
Alternating hemiplegia of childhood: treatment of attacks with chloral hydrate and niaprazine. (9039526)
1997
37
Comparison of two injection techniques using botulinum toxin in spastic hemiplegia. (8985111)
1996
38
Skeletal muscle mitochondrial dysfunction in alternating hemiplegia of childhood. (7574469)
1995
39
Impaired afferent control in patients with spastic hemiplegia at different recovery stages: contribution to gait disorder. (8129585)
1994
40
Benign familial nocturnal alternating hemiplegia of childhood. (7936227)
1994
41
Prognostic value of triple phase bone scanning for reflex sympathetic dystrophy in hemiplegia. (8328893)
1993
42
Rectal chloral hydrate for alternating hemiplegia of childhood. (2257994)
1990
43
Herpes zoster ophthalmicus, contralateral hemiplegia, and recurrent ocular toxoplasmosis in a patient with acquired immune deficiency syndrome-related complex. (2531159)
1989
44
Familial porencephaly and congenital hemiplegia. (3761085)
1986
45
Anatomopathology and pathogeny of the hemiconvulsion-hemiplegia-epilepsy syndrome. Part II. (536746)
1979
46
Physical therapy in the acute care hospital and nursing home: treatment for patients with hemiplegia due to cerebrovascular accident. (103036)
1978
47
Acute hemiplegia and cortical blindness due to moya moya disease: report of a case in a child with Down's syndrome. (141647)
1977
48
Herpes zoster ophthalmicus complicated by contralateral hemiplegia. (14414739)
1960
49
Electromyographic observations in spastic hemiplegia of corticospinal origin. (13042045)
1953
50
Erythromelalgia Consequent to Hemiplegia : With Report of a Case. (20892504)
1932

Genetic Variations for Hemiplegia

Expression for genes affiliated with Hemiplegia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hemiplegia

Search GEO for disease gene expression data for Hemiplegia.

Pathways for genes affiliated with Hemiplegia

Sources:
12EMD Millipore, 30KEGG, 38NCBI BioSystems Database
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Pathways related to Hemiplegia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2ATP1A2, ATP1A3
210.1SLC2A1, ATP1A2, ATP1A3
3
Hide members
10.1SLC2A1, ATP1A2, ATP1A3
410.1ATP1A2, COL4A2, ATP1A3
5
Hide members
10.1ATP1A2, SLC1A3, CACNA1A
69.8FEV, ATP1A3, TAC1, SLC1A3

Compounds for genes affiliated with Hemiplegia

Sources:
60Tocris Bioscience, 45Novoseek, 29IUPHAR, 50PharmGKB, 11DrugBank, 24HMDB
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Compounds related to Hemiplegia according to GeneCards/GeneDecks:

(show all 22)
idCompoundScoreTop Affiliating Genes
1lithium carbonate6010.5ATP1A2, ATP1A3
2estrogen4510.5TAC1
3rp6758045 2911.4TAC1, CALCA
4gr 7363245 6011.4TAC1, CALCA
5helospectin4510.4TAC1, CALCA
6resiniferatoxin45 2911.4TAC1, CALCA
7digoxin45 50 60 11 2414.4ATP1A3, ATP1A2, TAC1
8guanethidine45 1111.3TAC1, CALCA
9hydroxyproline45 11 2412.3CALCA, MMP9, ACP5
10cromakalim45 2911.3TAC1, CALCA
11l-nmma4510.2ACP5, MMP9, TAC1
12prostaglandin f2alpha4510.2SLC2A1, TAC1, CALCA
13i-app4510.2TAC1, CALCA
14capsazepine45 60 2912.1TAC1, CALCA
15gaba4510.1TAC1, MMP9, SLC2A1, SLC1A3
16tartrate4510.0ACP5, CALCA
17sodium45 2411.0CACNA1A, ATP1A3, ATP1A2, TAC1, SLC1A3
18adenylate459.9SLC1A3, SLC2A1, MMP9, TAC1, CALCA
19glutamate459.7SLC1A3, CALCA, CACNA1A, ATP1A2, TAC1, MMP9
20verapamil45 50 29 11 2413.7CACNA1A, TAC1, SLC2A1
21dexamethasone45 50 29 1112.6ACP5, SLC2A1, MMP9, TAC1, NR0B1
22cysteine459.5NR0B1, TAC1, MMP9, SLC2A1, SLC1A3, ACP5

GO Terms for genes affiliated with Hemiplegia

Sources:
16Gene Ontology
See all sources

Cellular components related to Hemiplegia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sodium:potassium-exchanging ATPase complexGO:00589010.2ATP1A2, ATP1A3
2neuronal cell bodyGO:0430259.5SLC1A3, TAC1, CACNA1A, CALCA

Biological processes related to Hemiplegia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neurotransmitter uptakeGO:00150410.3SLC1A3, ATP1A2
2response to painGO:04826510.1TAC1, CALCA
3regulation of blood pressureGO:00821710.0CALCA, ATP1A2, TAC1
4elevation of cytosolic calcium ion concentrationGO:0072049.9CALCA, CACNA1A, TAC1
5response to lipopolysaccharideGO:0324969.6LY96, ACP5, TAC1

Molecular functions related to Hemiplegia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sodium:potassium-exchanging ATPase activityGO:00539110.2ATP1A2, ATP1A3

Products for genes affiliated with Hemiplegia

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hemiplegia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet