MCID: HMP005
MIFTS: 44

Hemiplegia malady

Rare diseases, Neuronal diseases categories

Summaries for Hemiplegia

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MalaCards based summary: Hemiplegia, also known as postnatal infantile hemiplegia nos, is related to alternating hemiplegia of childhood and epilepsy syndrome. An important gene associated with Hemiplegia is ATP1A2 (ATPase, Na+/K+ transporting, alpha 2 polypeptide), and among its related pathways are Protein digestion and absorption and Hepatic ABC Transporters. The compounds lithium carbonate and digoxin have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and testes, and related mouse phenotypes are nervous system and behavior/neurological.

Aliases & Classifications for Hemiplegia

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Hemiplegia, Aliases & Descriptions:

Name: Hemiplegia 9 41 11
Postnatal Infantile Hemiplegia Nos 9
Infantile Hemiplegia Nos 9
 
Hemiplegia, Infantile 60
Infantile Hemiplegia 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


External Ids:

Disease Ontology9 DOID:10969
MeSH33 D006429
ICD9CM27 343.4
ICD1025 G81, G81.9

Related Diseases for Hemiplegia

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Diseases related to Hemiplegia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 285)
idRelated DiseaseScoreTop Affiliating Genes
1alternating hemiplegia of childhood31.8ATP1A2
2epilepsy syndrome30.7SLC2A1, ATP1A2
3migraine30.2SLC1A3, ATP1A2
4mental retardation29.4SLC1A3, NR0B1, ATP1A2
5spastic hemiplegia10.8
6spasticity10.8
7anosognosia10.7
8cerebritis10.6
9laryngitis10.4
10herpes zoster10.4
11herpes zoster ophthalmicus10.4
12hemiplegic migraine10.3
13alternating hemiplegia of childhood 210.3
14cerebral palsy10.3
15dystonia10.2
16reflex sympathetic dystrophy10.2
17episodic ataxia10.2
18porencephaly10.2
19encephalitis10.2
20benign familial nocturnal alternating hemiplegia of childhood10.2
21idiopathic hemiconvulsion-hemiplegia syndrome10.2
22masa syndrome10.1
23mucopolysaccharidosis is10.1
24familial hemiplegic migraine10.1
25epileptic hemiplegia10.1
26hemiplegia alterans10.1
27blindness10.1
28sneddon syndrome10.1
29brain injury10.1
30spastic diplegia10.1
31quadriplegia10.1
32cadasil10.1
33adams-oliver syndrome10.1
34aphasia10.1
35familial porencephaly10.1
36medial medullary syndrome10.1
37rhabdoid tumor10.1
38atp1a2-related alternating hemiplegia of childhood10.1
39atp1a3-related alternating hemiplegia of childhood10.1
40ataxia10.1
41startle epilepsy10.1
42movement disease10.0ATP1A3, SLC2A1
43rheumatoid arthritis10.0
44fucosidosis10.0
45schizencephaly10.0
46primary lateral sclerosis, juvenile10.0
47von hippel-lindau syndrome10.0
48vasculopathy, retinal, with cerebral leukodystrophy10.0
49pierson syndrome10.0
50parkes weber syndrome10.0

Graphical network of the top 20 diseases related to Hemiplegia:



Diseases related to hemiplegia

Symptoms for Hemiplegia

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Drugs & Therapeutics for Hemiplegia

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Drug clinical trials:

Search ClinicalTrials for Hemiplegia

Search NIH Clinical Center for Hemiplegia

Genetic Tests for Hemiplegia

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Anatomical Context for Hemiplegia

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MalaCards organs/tissues related to Hemiplegia:

31
Brain, Bone, Testes, Skin, Cortex, Spinal cord, Skeletal muscle, Kidney, Liver, Endothelial, Thalamus

Animal Models for Hemiplegia or affiliated genes

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MGI Mouse Phenotypes related to Hemiplegia:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036318.2SLC2A1, SLC1A3, ATP1A2, ATP1A3
2MP:00053867.9ATP1A3, ATP1A2, SLC1A3, SLC2A1
3MP:00053767.4SLC2A1, SLC1A3, NR0B1, ATP1A2, ATP1A3

Publications for Hemiplegia

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Articles related to Hemiplegia:

(show top 50)    (show all 685)
idTitleAuthorsYear
1
Postural stability in children with hemiplegia estimated for three postural conditions: standing, sitting and kneeling. (25677032)
2015
2
Sudden onset hemiplegia at high altitude. (25687257)
2015
3
Hemiconvulsion-hemiplegia-epilepsy syndrome with 1q44 microdeletion: Causal or chance association. (24214579)
2014
4
Error-based training and emergent awareness in anosognosia for hemiplegia. (25142215)
2014
5
Hemispherectomy in adults patients with severe unilateral epilepsy and hemiplegia. (23623848)
2013
6
Expected for acquisition movement exercise is more effective for functional recovery than simple exercise in a rat model of hemiplegia. (24255829)
2013
7
The effect of ankle-foot orthoses on self-reported balance confidence in persons with chronic poststroke hemiplegia. (23798045)
2013
8
Diffusion tensor imaging predicts the outcome of constraint-induced movement therapy in chronic infarction patients with hemiplegia: A pilot study. (23648673)
2013
9
A multi-site study of functional outcomes following a themed approach to hand-arm bimanual intensive therapy for children with hemiplegia. (23458353)
2013
10
Remission of anosognosia for right hemiplegia and neglect after caloric vestibular stimulation. (23142813)
2013
11
Practicing a matching movement with a mirror in individuals with spastic hemiplegia. (23751296)
2013
12
Functional studies and proteomics in platelets and fibroblasts reveal a lysosomal defect with increased cathepsin-dependent apoptosis in ATP1A3 defective alternating hemiplegia of childhood. (23681173)
2013
13
A plea for consideration of the less affected hand in therapeutic approaches to hemiplegia. (22348374)
2012
14
A pilot study of contralateral homonymous muscle activity simulated electrical stimulation in chronic hemiplegia. (22571491)
2012
15
47 year-old man with HIV infection and hemiplegia. (22697382)
2012
16
A case of rheumatoid arthritis with unilateral knee synovial hypertrophy in hemiplegia. (22506248)
2012
17
Current and future interventions for glenohumeral subluxation in hemiplegia secondary to stroke. (22982832)
2012
18
Child neurology: alternating hemiplegia of childhood. (20368625)
2010
19
A rare cause of hemiplegia. (20089026)
2010
20
Functional electrical stimulation to dorsiflexors and plantar flexors during gait to improve walking in adults with chronic hemiplegia. (20434604)
2010
21
Variable stimulation patterns for poststroke hemiplegia. (19086075)
2009
22
Verbal intelligence in Neglect: the role of anosognosia for hemiplegia. (19381128)
2009
23
Fast responses to target changes are not impaired in children with spastic hemiplegia. (18987560)
2009
24
Reality monitoring in anosognosia for hemiplegia. (19195910)
2009
25
Babinski's anosognosia for hemiplegia in early twentieth-century French neurology. (20183220)
2009
26
Anosognosia for right hemiplegia from dominant anterior cerebral artery stroke. (19570175)
2009
27
Hemiplegia with dysarthria: an initial manifestation of Japanese encephalitis in a 4-year old child. (19248662)
2008
28
Bilateral training does not facilitate performance of copying tasks in poststroke hemiplegia. (17082503)
2006
29
Impairments in precision grip correlate with functional measures in adult hemiplegia. (16679058)
2006
30
Etiology of strokes and hemiplegia in children presenting at Ayub Teaching Hospital, Abbottabad. (16977817)
2006
31
Hemiconvulsion-hemiplegia-epilepsy syndrome as a presenting feature of L-2-hydroxyglutaric aciduria. (16948946)
2006
32
Alternating hemiplegia of childhood successfully treated with topiramate: 18 months of follow-up. (16401872)
2006
33
Topiramate: a new agent for patients with alternating hemiplegia of childhood. (17177149)
2006
34
Alternating hemiplegia of childhood: a study of neuropsychological functioning. (15788223)
2005
35
Idiopathic infantile asymmetry and infantile hemiplegia. (15935935)
2005
36
Hemiplegia of the will and trends in stroke incidence. (15696872)
2004
37
Functional gait changes in patients with chronic lower extremity hemiplegia treated with a technology to induce movement (TIM)-type system. (15592989)
2004
38
Novel approach for spastic hemiplegia classification through the use of support vector machines. (17271714)
2004
39
Mobility and muscle strength contralateral to hemiplegia from stroke: benefit from self-training with family support. (12820789)
2003
40
Recovery from complete hemiplegia following resection of a retrocentral metastasis: the prognostic value of intraoperative cortical stimulation. (11765822)
2001
41
Alternating hemiplegia of childhood in half-sisters. (10695898)
2000
42
Is alternating hemiplegia of childhood (AHC) a variant of migraine? (11167894)
2000
43
Acute childhood hemiplegia associated with chickenpox. (9568925)
1998
44
Anosognosia for hemiplegia: patient retrospections. (16571488)
1996
45
Dissociation of anosognosia for hemiplegia and aphasia during left-hemisphere anesthesia. (7824138)
1995
46
Impaired afferent control in patients with spastic hemiplegia at different recovery stages: contribution to gait disorder. (8129585)
1994
47
Gait patterns in spastic hemiplegia in children and young adults. (3667656)
1987
48
Hemiplegia in homocystinuria. (3793712)
1986
49
Physical therapy in the acute care hospital and nursing home: treatment for patients with hemiplegia due to cerebrovascular accident. (103036)
1978
50
Herpes zoster ophthalmicus with contralateral hemiplegia. (303089)
1977

Variations for Hemiplegia

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Expression for genes affiliated with Hemiplegia

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Search GEO for disease gene expression data for Hemiplegia.

Pathways for genes affiliated with Hemiplegia

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Pathways related to Hemiplegia according to GeneCards Suite gene sharing:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5ATP1A2, ATP1A3
2
Show member pathways
9.5ATP1A2, ATP1A3
39.5ATP1A3, ATP1A2
49.5ATP1A3, ATP1A2
5
Show member pathways
9.5ATP1A2, ATP1A3
6
Show member pathways
9.5ATP1A2, ATP1A3
7
Show member pathways
9.5ATP1A3, ATP1A2
89.5ATP1A2, ATP1A3
99.5ATP1A3, ATP1A2
109.5ATP1A2, ATP1A3
119.5ATP1A3, ATP1A2
12
Show member pathways
calcium transport I36
9.5ATP1A2, ATP1A3
13
Show member pathways
9.5ATP1A2, ATP1A3
149.5ATP1A2, ATP1A3
15
Show member pathways
Synaptic Vesicle Pathway36
9.2SLC1A3, ATP1A2
169.1SLC1A3, ATP1A3
17
Show member pathways
9.0SLC2A1, ATP1A2, ATP1A3
189.0ATP1A3, ATP1A2, SLC2A1
199.0SLC2A1, ATP1A2, ATP1A3
20
Show member pathways
8.2ATP1A3, ATP1A2, SLC1A3, SLC2A1

Compounds for genes affiliated with Hemiplegia

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Compounds related to Hemiplegia according to GeneCards Suite gene sharing:

idCompoundScoreTop Affiliating Genes
1lithium carbonate599.7ATP1A2, ATP1A3
2digoxin43 59 49 24 1213.6ATP1A2, ATP1A3
3inositol439.1SLC1A3, SLC2A1
4gaba439.1SLC2A1, SLC1A3
5sodium43 249.8ATP1A3, ATP1A2, SLC1A3
6glutamate438.7SLC2A1, SLC1A3, ATP1A2
7cysteine438.4SLC2A1, SLC1A3, NR0B1
8glucose438.4SLC2A1, SLC1A3, ATP1A2

GO Terms for genes affiliated with Hemiplegia

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Cellular components related to Hemiplegia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1sodium:potassium-exchanging ATPase complexGO:00058909.6ATP1A2, ATP1A3
2caveolaGO:00059019.5SLC2A1, ATP1A2
3synapseGO:00452029.2ATP1A2, ATP1A3
4membraneGO:00160208.4NR0B1, SLC1A3, SLC2A1
5plasma membraneGO:00058868.2SLC2A1, SLC1A3, ATP1A2, ATP1A3

Biological processes related to Hemiplegia according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1ATP biosynthetic processGO:00067549.6ATP1A2, ATP1A3
2visual learningGO:00085429.5ATP1A3, ATP1A2
3ion transmembrane transportGO:00342209.5ATP1A2, ATP1A3
4adult locomotory behaviorGO:00083449.4ATP1A2, ATP1A3
5neurotransmitter uptakeGO:00015049.3SLC1A3, ATP1A2
6sodium ion transmembrane transportGO:00357259.2ATP1A2, ATP1A3
7transmembrane transportGO:00550858.3SLC2A1, SLC1A3, ATP1A2, ATP1A3

Molecular functions related to Hemiplegia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1sodium:potassium-exchanging ATPase activityGO:00053919.5ATP1A2, ATP1A3

Products for genes affiliated with Hemiplegia

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  • Antibodies
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Sources for Hemiplegia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet