MCID: HMP006
MIFTS: 51

Hemiplegic Migraine malady

Genetic diseases, Rare diseases, Neuronal diseases categories
Download this MalaCard

Summaries for Hemiplegic Migraine

About this section


Fully expand this MalaCard
NIH Rare Diseases:42 Hemiplegic migraine refers to migraine with aura accompanied with motor weakness. signs and symptoms vary but may include visual disturbance, sensory loss, difficulty with speech, weakness on one side of the body, confusion, and impaired consciousness. frequency of hemiplegic migraine can vary considerably. it can take time for symptoms to resolve, but permanent motor, sensory, language, or visual symptoms are extremely rare. it can occur as a sporadic or genetic disorder. when inherited, it is passed through families in an autosomal dominant fashion. last updated: 8/26/2013

MalaCards based summary: Hemiplegic Migraine, also known as migraine hemiplegic, is related to migraine and familial hemiplegic migraine. An important gene associated with Hemiplegic Migraine is CACNA1A (calcium channel, voltage-dependent, P/Q type, alpha 1A subunit), and among its related pathways are Interaction between L1 and Ankyrins and Proximal tubule bicarbonate reclamation. The compounds bc-iii and atx-ii have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and cortex, and related mouse phenotypes are normal and respiratory system.

Wikipedia:65 Familial hemiplegic migraine (FHM) is an autosomal dominant classical migraine subtype that typically... more...

Aliases & Classifications for Hemiplegic Migraine

About this section
Sources:
42NIH Rare Diseases, 62UMLS, 44Novoseek
See all sources

Hemiplegic Migraine, Aliases & Descriptions:

Name: Hemiplegic Migraine 42 62
 
Migraine Hemiplegic 44


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Neuronal diseases


Related Diseases for Hemiplegic Migraine

About this section

Diseases in the Familial Hemiplegic Migraine Type 1 family:

Familial Hemiplegic Migraine Familial Hemiplegic Migraine Type 2
Familial Hemiplegic Migraine Type 3 hemiplegic migraine

Diseases related to Hemiplegic Migraine via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 62)
idRelated DiseaseScoreTop Affiliating Genes
1migraine31.9ATP1A2, CACNA1A, NOTCH3, PRRT2, SCN1A, CALCA
2familial hemiplegic migraine31.9SCN1A, DNAH8, CACNA1A, ATP1A2, NOTCH3
3alternating hemiplegia of childhood31.6ATP1A2
4hemiplegia31.4CACNA1A, ATP1A2
5sporadic hemiplegic migraine11.0
6familial hemiplegic migraine type 110.9
7familial hemiplegic migraine type 210.8
8ataxia10.8
9cerebritis10.7
10familial hemiplegic migraine type 310.7
11neuronitis10.7
12cerebellar ataxia10.6
13episodic ataxia10.6
14benign familial infantile epilepsy10.5ATP1A2
15epilepsy syndrome10.4PRRT2
16cadasil10.4
17migraine with aura10.4
18sturge-weber syndrome10.4
19weber syndrome10.4
20dravet syndrome10.4SCN1A
21migraine without aura10.4CACNA1A, ATP1A2
22hypertension10.3
23patent foramen ovale10.3
24moyamoya disease10.3
25dystonia10.3
26meningitis10.3
27retinal degeneration10.3
28retinitis10.3
29spinocerebellar ataxia10.3
30episodic ataxia type 210.3
31spinocerebellar ataxia type 610.3
32mental retardation10.3
33cluster headache10.3CALCA, CACNA1A
34idiopathic generalized epilepsy10.3CACNA1A, SCN1A
35cystic fibrosis10.2
36progressive hemifacial atrophy10.2
37status epilepticus10.2
38mitral valve prolapse10.2
39erdheim-chester disease10.2
40aseptic meningitis10.2
41arteriovenous malformation10.2
42crest syndrome10.2
43intracranial hypertension10.2
44ischemia10.2
45mood disorder10.2
46basilar migraine10.2
47hemicrania continua10.2
48pulmonary arteriovenous malformation10.2
49spastic paraparesis10.2
50cerebral atrophy10.2

Graphical network of the top 20 diseases related to Hemiplegic Migraine:



Diseases related to hemiplegic migraine

Symptoms for Hemiplegic Migraine

About this section

Drugs & Therapeutics for Hemiplegic Migraine

About this section

Drug clinical trials:

Search ClinicalTrials for Hemiplegic Migraine

Search NIH Clinical Center for Hemiplegic Migraine

Genetic Tests for Hemiplegic Migraine

About this section

Anatomical Context for Hemiplegic Migraine

About this section

MalaCards organs/tissues related to Hemiplegic Migraine:

32
Brain, Testes, Cortex, Cerebellum, Thalamus, Trigeminal ganglion, Tongue

Animal Models for Hemiplegic Migraine or affiliated genes

About this section

MGI Mouse Phenotypes related to Hemiplegic Migraine:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.5ATP1A2, SCN1A, SCN5A, CACNA1A, CALCA, OPRM1
2MP:00053888.3ATP1A2, GNB1, GNAI2, CACNA1A, CALCA, NOTCH3
3MP:00053847.8GNB1, GNAI2, SCN5A, PRKCSH, CACNA1A, OPRM1
4MP:00053867.4NOTCH3, ATP1B2, ATP1A2, GNB1, GNAI2, SCN1A
5MP:00036317.3ATP1B2, ATP1A2, GNB1, GNAI2, SCN1A, SCN5A
6MP:00107687.0GNAI2, GNB1, ATP1A2, ATP1B2, SCN1A, SCN5A

Publications for Hemiplegic Migraine

About this section

Articles related to Hemiplegic Migraine:

(show top 50)    (show all 361)
idTitleAuthorsYear
1
PRRT2 and hemiplegic migraine: a complex association. (24928127)
2014
2
Hemiplegic migraine: neuroimaging findings during a hemiplegic migraine attack. (24512003)
2014
3
A novel ATP1A2 gene mutation in familial hemiplegic migraine and epilepsy. (23918834)
2014
4
Familial hemiplegic migraine and spreading depression. (25143767)
2014
5
Delayed recovery post anesthesia: an atypical presentation of familial hemiplegic migraine. (24347352)
2013
6
Magnetic Resonance Angiography Evidence of Vasospasm in Children With Suspected Acute Hemiplegic Migraine. (23594822)
2013
7
Hemiplegic migraine with reversible cerebral vasoconstriction caused by ATP1A2 mutations. (23821026)
2013
8
Functional characterization of a novel C-terminal ATP1A2 mutation causing hemiplegic migraine and epilepsy. (23838748)
2013
9
Pulmonary arterial hypertension in familial hemiplegic migraine with ATP1A2 channelopathy. (24136331)
2013
10
Familial hemiplegic migraine with prolonged global aura: follow-up findings of subtraction ictal SPECT co-registered to MRI (SISCOM). (22933508)
2012
11
Stroke and familial hemiplegic migraine. (22608661)
2012
12
Calcitonin gene-related peptide does not cause migraine attacks in patients with familial hemiplegic migraine. (21457239)
2011
13
Increased susceptibility to cortical spreading depression in the mouse model of familial hemiplegic migraine type 2. (21731499)
2011
14
Transient nonverbal learning disorder in a child suffering from Familial Hemiplegic Migraine. (21908445)
2011
15
A novel mutation in CACNA1A associated with hemiplegic migraine, cerebellar dysfunction and late-onset cognitive decline. (21035146)
2011
16
Acute striatal necrosis in hemiplegic migraine with de novo CACNA1A mutation. (22082423)
2011
17
Enhanced subcortical spreading depression in familial hemiplegic migraine type 1 mutant mice. (21490217)
2011
18
De novo mutations in ATP1A2 and CACNA1A are frequent in early-onset sporadic hemiplegic migraine. (20837964)
2010
19
Insights into migraine mechanisms and CaV2.1 calcium channel function from mouse models of familial hemiplegic migraine. (20194127)
2010
20
Moyamoya disease presented as a case of hemiplegic migraine. (22798438)
2010
21
Neurological picture. Cortical oedema: a link between delusional misidentification syndromes and hemiplegic migraine. (20019221)
2010
22
Coexisting typical migraine in familial hemiplegic migraine. (20157162)
2010
23
Large scale calcium channel gene rearrangements in episodic ataxia and hemiplegic migraine: implications for diagnostic testing. (19586927)
2009
24
Familial hemiplegic migraine is associated with febrile seizures in an FHM2 family with a novel de novo ATP1A2 mutation. (19874388)
2009
25
Genetic analysis of 27 Spanish patients with hemiplegic migraine, basilar-type migraine and childhood periodic syndromes. (18644040)
2008
26
Diverse functional consequences of mutations in the Na+/K+-ATPase alpha2-subunit causing familial hemiplegic migraine type 2. (18728015)
2008
27
Sporadic hemiplegic migraine: report of a case with clinical and radiological features. (18810316)
2008
28
A novel de novo nonsense mutation in ATP1A2 associated with sporadic hemiplegic migraine and epileptic seizures. (18644608)
2008
29
Recurrent ATP1A2 mutations in Portuguese families with familial hemiplegic migraine. (17952365)
2007
30
Sporadic and familial hemiplegic migraine: diagnosis and treatment. (16628531)
2006
31
Alterations in the alpha2 isoform of Na,K-ATPase associated with familial hemiplegic migraine type 2. (16037212)
2005
32
Single-fiber EMG in familial hemiplegic migraine. (15883351)
2005
33
Familial hemiplegic migraine type 1 mutations K1336E, W1684R, and V1696I alter Cav2.1 Ca2+ channel gating: evidence for beta-subunit isoform-specific effects. (15448138)
2004
34
Phenotypes of spinocerebellar ataxia type 6 and familial hemiplegic migraine caused by a unique CACNA1A missense mutation in patients from a large family. (12707077)
2003
35
Serial MRI in a case of familial hemiplegic migraine. (12669159)
2003
36
Treatment of sporadic hemiplegic migraine with calcium-channel blocker verapamil. (12525732)
2003
37
Magnetic resonance angiogram evidence of vasospasm in familial hemiplegic migraine. (12174974)
2002
38
Idiopathic intracranial hypertension presenting as hemiplegic migraine. (12222727)
2002
39
Mutation analysis of the CACNA1A calcium channel subunit gene in 27 patients with sporadic hemiplegic migraine. (12056940)
2002
40
Multimodal functional imaging of prolonged neurological deficits in a patient suffering from familial hemiplegic migraine. (12384224)
2002
41
Migraine with aura susceptibility locus on chromosome 19p13 is distinct from the familial hemiplegic migraine locus. (11735221)
2001
42
Familial hemiplegic migraine: a ion channel disorder. (11719257)
2001
43
The clinical spectrum of familial hemiplegic migraine associated with mutations in a neuronal calcium channel. (11439943)
2001
44
Motor cortex excitability in patients with migraine with aura and hemiplegic migraine. (10817446)
2000
45
Functional consequences of mutations in the human alpha1A calcium channel subunit linked to familial hemiplegic migraine. (10024348)
1999
46
A new locus for hemiplegic migraine maps to chromosome 1q31. (9371899)
1997
47
Wolff Award 1997. Involvement of a Ca2+ channel gene in familial hemiplegic migraine and migraine with and without aura. Dutch Migraine Genetics Research Group. (9329229)
1997
48
Hemiplegic migraine. (2391303)
1990
49
Unusual angiographic appearance during attack of hemiplegic migraine. (3721866)
1986
50
Hemiplegic migraine. (7288457)
1981

Variations for Hemiplegic Migraine

About this section

Expression for genes affiliated with Hemiplegic Migraine

About this section
Expression patterns in normal tissues for genes affiliated with Hemiplegic Migraine

Search GEO for disease gene expression data for Hemiplegic Migraine.

Pathways for genes affiliated with Hemiplegic Migraine

About this section

Pathways related to Hemiplegic Migraine according to GeneCards/GeneDecks:

(show top 50)    (show all 58)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9SCN5A, SCN1A
2
Show member pathways
9.8ATP1B2, ATP1A2
39.8ATP1A2, ATP1B2
49.6NOTCH3, ATP1A2, ATP1B2
5
Show member pathways
9.5GNAI2, ATP1A2, ATP1B2
69.3GNG2, GNB1
79.3GNG2, GNB1
89.3GNB1, GNG2
9
Show member pathways
9.3SCN1A, ATP1B2, SCN5A, ATP1A2
109.2SCN5A, GNAI2, ATP1B2, ATP1A2
11
Show member pathways
9.0GNB1, GNAI2, GNG2
129.0GNB1, GNAI2, GNG2
13
Show member pathways
9.0GNB1, GNAI2, GNG2
14
Show member pathways
Apoptosis and survival BAD phosphorylation60
Development Alpha 2 adrenergic receptor activation of ERK60
Chemotaxis CXCR4 signaling pathway60
9.0GNB1, GNAI2, GNG2
15
Show member pathways
Development Beta adrenergic receptors regulation of ERK60
G protein signaling G Protein alpha s signaling cascades60
G protein signaling G Protein beta gamma signaling cascades60
9.0GNB1, GNAI2, GNG2
16
Show member pathways
Signal transduction cAMP signaling60
9.0GNB1, GNG2, GNAI2
17
Show member pathways
9.0GNAI2, GNG2, GNB1
18
Show member pathways
9.0GNB1, GNG2, GNAI2
19
Show member pathways
9.0GNB1, GNG2, GNAI2
20
Show member pathways
Development A1 receptor signaling60
G protein signaling G Protein alpha q signaling cascades60
9.0GNAI2, GNG2, GNB1
21
Show member pathways
Cytoskeleton remodeling Reverse signaling by ephrin B60
9.0GNAI2, GNB1, GNG2
22
Show member pathways
G protein signaling G Protein alpha 12 signaling pathway60
9.0GNG2, GNB1, GNAI2
23
Show member pathways
9.0GNAI2, GNB1, GNG2
24
Show member pathways
9.0GNAI2, GNG2, GNB1
259.0GNAI2, GNB1, GNG2
269.0GNAI2, GNG2, GNB1
279.0GNG2, GNB1, GNAI2
288.7CACNA1A, GNB1, GNG2, GNAI2
29
Show member pathways
8.7GNB1, CACNA1A, GNG2, GNAI2
30
Show member pathways
8.7CACNA1A, GNB1, GNAI2, GNG2
31
Show member pathways
8.7CACNA1A, GNAI2, GNG2, GNB1
32
Show member pathways
8.7GNG2, GNB1, CACNA1A, GNAI2
33
Show member pathways
8.7GNB1, GNAI2, CACNA1A, GNG2
34
Show member pathways
8.7CACNA1A, GNAI2, GNG2, GNB1
35
Show member pathways
8.7GNG2, GNAI2, CACNA1A, GNB1
36
Show member pathways
8.7GNG2, GNAI2, CACNA1A, GNB1
37
Show member pathways
8.7GNB1, GNG2, GNAI2, CACNA1A
38
Show member pathways
8.7GNG2, ATP1B2, ATP1A2, GNB1
39
Show member pathways
8.6GNB1, GNG2, CALCA, GNAI2
408.6GNAI2, GNB1, CALCA, GNG2
41
Show member pathways
8.6OPRM1, GNAI2, GNG2, GNB1
42
Show member pathways
8.5GNAI2, GNG2, GNB1, ATP1B2
43
Show member pathways
8.5GNAI2, GNB1, GNG2, NOTCH3, CACNA1A
44
Show member pathways
8.3OPRM1, CALCA, GNAI2, GNG2, GNB1
45
Show member pathways
8.3GNB1, GNG2, GNAI2, CALCA, OPRM1
46
Show member pathways
8.2SCN1A, SCN5A, GNAI2, CACNA1A, GNG2, GNB1
47
Show member pathways
8.2GNB1, GNAI2, SCN1A, GNG2, CACNA1A, SCN5A
48
Show member pathways
8.2GNB1, GNG2, CACNA1A, GNAI2, OPRM1, SCN1A
49
Show member pathways
8.0GNB1, CALCA, GNG2, OPRM1, GNAI2, NOTCH3
50
Show member pathways
Calcium Regulation in the Cardiac Cell37
8.0CALCA, GNB1, GNG2, GNAI2, CACNA1A, ATP1B2

Compounds for genes affiliated with Hemiplegic Migraine

About this section

Compounds related to Hemiplegic Migraine according to GeneCards/GeneDecks:

(show all 35)
idCompoundScoreTop Affiliating Genes
1bc-iii2810.3SCN1A, SCN5A
2atx-ii2810.3SCN1A, SCN5A
3aft-ii2810.3SCN1A, SCN5A
4batrachotoxin2810.3SCN1A, SCN5A
5qx 314 chloride6110.2SCN1A, SCN5A
6tetrodotoxin citrate6110.2SCN1A, SCN5A
7phrixotoxin 36110.2SCN1A, SCN5A
8veratridine44 61 2812.2SCN1A, SCN5A
9lithium carbonate6110.2ATP1B2, ATP1A2
10loperamide44 24 1112.1CACNA1A, OPRM1
11tetrodotoxin44 61 2812.0CALCA, SCN5A, SCN1A
12zonisamide44 50 1111.9SCN5A, SCN1A
13heroin44 50 1111.9CALCA, OPRM1
14lidocaine44 28 1111.7OPRM1, SCN5A
15bepridil44 28 1111.7DNAH8, CACNA1A
16ether44 5010.5CALCA, DNAH8
17sodium44 2410.5ATP1B2, ATP1A2, SCN1A, SCN5A, CACNA1A
18verapamil44 28 50 24 1113.4CACNA1A, DNAH8, SCN5A
19digoxin44 61 50 24 1113.4DNAH8, ATP1A2, ATP1B2
20gallein619.4GNAI2, GNG2, GNB1
21clonidine44 50 28 1112.4DNAH8, CALCA, OPRM1
22g-protein antagonist peptide619.4GNAI2, GNG2, GNB1
23suramin hexasodium salt619.4GNB1, GNG2, GNAI2
248-bromo-cgmp, sodium salt619.4GNB1, GNG2, GNAI2
25pertussis toxin619.4GNB1, GNG2, GNAI2
265-hydroxytryptamine449.2OPRM1, CALCA, DNAH8
27potassium44 24 1111.1OPRM1, CACNA1A, SCN5A, SCN1A, ATP1A2, ATP1B2
28Guanosine monophosphate249.1GNAI2, GNG2, GNB1
29acetylcholine44 50 28 24 1113.1OPRM1, CALCA, CACNA1A, DNAH8
30glutamine449.1SCN5A, DNAH8, CACNA1A, OPRM1
31quinidine44 28 50 1112.1DNAH8, SCN5A
32Guanosine diphosphate249.0GNAI2, GNG2, GNB1
33epinephrine44 24 1111.0DNAH8, CALCA, OPRM1
34glutamate448.9ATP1A2, DNAH8, CACNA1A, CALCA, OPRM1
35calcium44 50 24 1111.3ATP1A2, SCN5A, DNAH8, CACNA1A, CALCA, OPRM1

GO Terms for genes affiliated with Hemiplegic Migraine

About this section

Cellular components related to Hemiplegic Migraine according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sodium:potassium-exchanging ATPase complexGO:0058909.8ATP1A2, ATP1B2
2voltage-gated sodium channel complexGO:0015189.8SCN1A, SCN5A
3T-tubuleGO:0303159.8ATP1A2, SCN1A, SCN5A
4neuronal cell bodyGO:0430259.7CALCA, CACNA1A, SCN1A
5intercalated discGO:0147049.6SCN5A, SCN1A
6heterotrimeric G-protein complexGO:0058349.0GNAI2, GNG2, GNB1
7plasma membraneGO:0058867.1NOTCH3, ATP1B2, ATP1A2, GNB1, GNG2, GNAI2

Biological processes related to Hemiplegic Migraine according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1neuromuscular process controlling postureGO:05088410.2PRRT2, SCN1A
2regulation of cardiac muscle cell contractionGO:08600410.2SCN5A, ATP1A2
3negative regulation of cytosolic calcium ion concentrationGO:05148110.2OPRM1, ATP1A2
4membrane depolarizationGO:05189910.1CACNA1A, SCN5A
5gamma-aminobutyric acid signaling pathwayGO:00721410.1CACNA1A, GNAI2
6sodium ion transportGO:00681410.0ATP1A2, SCN1A, SCN5A
7regulation of heart rateGO:00202710.0CALCA, SCN5A
8adult walking behaviorGO:0076289.9CACNA1A, SCN1A
9negative regulation of adenylate cyclase activityGO:0071949.9GNAI2, OPRM1
10G-protein coupled acetylcholine receptor signaling pathwayGO:0072139.9GNB1, GNAI2
11adenylate cyclase-inhibiting G-protein coupled receptor signaling pathwayGO:0071939.8OPRM1, GNAI2
12cellular response to catecholamine stimulusGO:0718709.7GNG2, GNB1
13cellular response to prostaglandin E stimulusGO:0713809.6GNG2, GNB1
14sodium ion transmembrane transportGO:0357259.6ATP1B2, ATP1A2, SCN1A, SCN5A
15positive regulation of cytosolic calcium ion concentrationGO:0072049.4OPRM1, CALCA, CACNA1A, GNB1
16energy reserve metabolic processGO:0061129.4GNB1, GNG2, CACNA1A
17adenylate cyclase-activating dopamine receptor signaling pathwayGO:0071919.3OPRM1, GNG2, GNB1
18cellular response to glucagon stimulusGO:0713779.3GNB1, GNG2
19phospholipase C-activating G-protein coupled receptor signaling pathwayGO:0072009.3OPRM1, GNB1
20platelet activationGO:0301689.0GNAI2, GNG2, GNB1
21synaptic transmissionGO:0072689.0CACNA1A, GNAI2, GNG2, GNB1
22blood coagulationGO:0075968.8ATP1B2, GNB1, GNG2, GNAI2

Molecular functions related to Hemiplegic Migraine according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sodium:potassium-exchanging ATPase activityGO:0053919.8ATP1A2, ATP1B2
2voltage-gated sodium channel activityGO:0052489.8SCN5A, SCN1A
3voltage-gated calcium channel activityGO:0052459.6OPRM1, CACNA1A
4signal transducer activityGO:0048719.0GNAI2, GNG2, GNB1

Products for genes affiliated with Hemiplegic Migraine

About this section
  • Antibodies
  • Proteins
  • Lysates

Sources for Hemiplegic Migraine

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet