MCID: HMP006
MIFTS: 31

Hemiplegic Migraine malady

Summaries for Hemiplegic Migraine

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Hemiplegic migraine refers to migraine with aura accompanied with motor weakness. signs and symptoms vary but may include visual disturbance, sensory loss, difficulty with speech, weakness on one side of the body, confusion, and impaired consciousness. frequency of hemiplegic migraine can vary considerably. it can take time for symptoms to resolve, but permanent motor, sensory, language, or visual symptoms are extremely rare. it can occur as a sporadic or genetic disorder. when inherited, it is passed through families in an autosomal dominant fashion. last updated: 8/26/2013

MalaCards: Hemiplegic Migraine, also known as migraine hemiplegic, is related to migraine and familial hemiplegic migraine. An important gene associated with Hemiplegic Migraine is CACNA1A (calcium channel, voltage-dependent, P/Q type, alpha 1A subunit), and among its related pathways are Adrenoceptors and Proximal tubule bicarbonate reclamation. The compounds aft-ii and bc-iii have been mentioned in the context of this disorder. Related mouse phenotypes are normal and homeostasis/metabolism.

Wikipedia:63 Familial hemiplegic migraine (FHM) is an autosomal dominant classical migraine subtype that typically... more...

Aliases & Classifications for Hemiplegic Migraine

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42NIH Rare Diseases, 60UMLS, 44Novoseek
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Aliases & Descriptions:

hemiplegic migraine 42 60
migraine hemiplegic 44


Related Diseases for Hemiplegic Migraine

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17GeneCards, 18GeneDecks
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Diseases in the Familial Hemiplegic Migraine Type 1 family:

Familial Hemiplegic Migraine Familial Hemiplegic Migraine Type 2
Familial Hemiplegic Migraine Type 3 hemiplegic migraine

Diseases related to Hemiplegic Migraine via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 43)
idRelated DiseaseScoreTop Affiliating Genes
1migraine32.0NOTCH3, CALCA, CACNA1A, SCN1A, ATP1A2, PRRT2
2familial hemiplegic migraine31.9CACNA1A, SCN1A, ATP1A2, DNAH8, NOTCH3
3migraine with aura31.0CACNA1E
4alternating hemiplegia of childhood30.8ATP1A2
5hemiplegia30.7ATP1A2, CACNA1A
6migraine without aura30.5CACNA1E
7episodic ataxia type 230.4CACNA1A
8hypertension30.4DNAH8, CALCA
9spinocerebellar ataxia type 630.1CACNA1A
10ischemia30.1SCN5A, ATP1A2, DNAH8
11familial hemiplegic migraine type 110.7
12cerebritis10.7
13familial hemiplegic migraine type 210.7
14familial hemiplegic migraine type 310.7
15neuronitis10.6
16sporadic hemiplegic migraine10.6
17episodic ataxia10.5
18cerebellar ataxia10.5
19cadasil10.4
20moyamoya disease10.3
21patent foramen ovale10.3
22meningitis10.3
23retinal degeneration10.3
24retinitis10.3
25mitral valve prolapse10.1
26cystic fibrosis10.1
27status epilepticus10.1
28erdheim-chester disease10.1
29arteriovenous malformation10.1
30aseptic meningitis10.1
31intracranial hypertension10.1
32mood disorder10.1
33spinocerebellar ataxia10.1
34image syndrome10.1
35hemiplegia alterans10.1
36benign familial infantile epilepsy10.0ATP1A2
37idiopathic generalized epilepsy10.0CACNA1A, SCN1A
38diabetes mellitus10.0DNAH8, CALCA
39cholera10.0DNAH8, CALCA
40essential hypertension10.0CACNA1B
41amnestic disorder10.0DNAH8, OPRM1
42neuropathy10.0DNAH8, CACNA1A, CALCA
43epilepsy syndrome10.0CACNA1A, SCN1A, OPRM1, ATP1A2, DNAH8

Graphical network of the top 20 diseases related to Hemiplegic Migraine:



Diseases related to hemiplegic migraine

Clinical Features for Hemiplegic Migraine

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Drugs & Therapeutics for Hemiplegic Migraine

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Hemiplegic Migraine

Drug clinical trials:

Search ClinicalTrials for Hemiplegic Migraine

Search NIH Clinical Center for Hemiplegic Migraine

Search CenterWatch for Hemiplegic Migraine

Genetic Tests for Hemiplegic Migraine

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Anatomical Context for Hemiplegic Migraine

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Animal Models for Hemiplegic Migraine or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Hemiplegic Migraine:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.3CALCA, CACNA1E, CACNA1A, SCN5A, OPRM1, ATP1A2
2MP:00053767.7CACNA1E, CACNA1A, CACNA1B, OPRM1, ATP1A2, PRKCSH
3MP:00107686.8GNB1, CACNA1B, CACNA1A, CALCA, SCN5A, SCN1A
4MP:00053866.8CACNA1B, CACNA1A, CACNA1E, CALCA, GNB1, SCN5A
5MP:00036316.3NOTCH3, CALCA, CACNA1E, CACNA1A, CACNA1B, GNB1

Publications for Hemiplegic Migraine

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Genetic Variations for Hemiplegic Migraine

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Expression for genes affiliated with Hemiplegic Migraine

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hemiplegic Migraine

Search GEO for disease gene expression data for Hemiplegic Migraine.

Pathways for genes affiliated with Hemiplegic Migraine

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53Reactome, 49PharmGKB, 29KEGG, 12EMD Millipore, 37NCBI BioSystems Database, 51QIAGEN
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Pathways related to Hemiplegic Migraine according to GeneCards/GeneDecks:

(show all 36)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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9.9CACNA1B, CACNA1A
29.8ATP1A2, ATP1B2
39.8ATP1B2, ATP1A2
4
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9.7ATP1A2, CACNA1B, CACNA1A
5
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9.5CACNA1E, CACNA1A, CACNA1B
69.5CACNA1B, CACNA1A, CACNA1E
7
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9.5CACNA1B, CACNA1A, CACNA1E
8
Development Ligand-independent activation of ESR1 and ESR2
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9.5CACNA1B, CACNA1A, CACNA1E
99.5CACNA1E, CACNA1A, CACNA1B
109.5CACNA1B, CACNA1A, CACNA1E
119.5CACNA1E, CACNA1A, CACNA1B
129.5CACNA1E, CACNA1A, CACNA1B
13
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9.5CACNA1B, ATP1B2, ATP1A2
14
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9.3SCN5A, SCN1A, ATP1B2, ATP1A2
159.3CACNA1E, CACNA1A, CACNA1B, SCN1A
169.3NOTCH3, CACNA1B, CACNA1A, CACNA1E
17
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9.1GNB1, CACNA1B, CACNA1A
189.0GNG2, GNB1
19
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8.5CACNA1A, CACNA1B, GNB1, GNG2
20
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8.4CALCA, GNB1, GNG2, OPRM1
21
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8.4CACNA1E, CACNA1A, GNB1, GNG2
22
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8.4CACNA1B, GNB1, GNG2, OPRM1
23
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8.1CACNA1E, CACNA1A, CACNA1B, GNB1, GNG2
24
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8.1CACNA1E, CACNA1A, CACNA1B, GNB1, GNG2
25
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8.1CACNA1E, CACNA1A, CACNA1B, GNB1, GNG2
26
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8.1GNG2, GNB1, CACNA1B, CACNA1A, CACNA1E
27
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8.1CACNA1E, CACNA1A, CACNA1B, GNB1, GNG2
28
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8.1GNG2, GNB1, CACNA1B, CACNA1A, CACNA1E
29
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8.1CACNA1E, CACNA1A, CACNA1B, GNB1, GNG2
30
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8.1GNG2, GNB1, CACNA1B, CACNA1A, CACNA1E
318.1CACNA1E, CACNA1A, CACNA1B, GNB1, GNG2
32
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7.9CACNA1A, CACNA1B, GNB1, GNG2, SCN1A, OPRM1
33
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7.9NOTCH3, GNG2, GNB1, CACNA1B, CACNA1A, CACNA1E
34
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7.6CACNA1E, CACNA1A, CACNA1B, GNB1, GNG2, SCN5A
35
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7.6CACNA1E, CACNA1A, CACNA1B, GNB1, GNG2, SCN5A
36
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7.4ATP1B2, CALCA, CACNA1E, CACNA1A, CACNA1B, GNB1

Compounds for genes affiliated with Hemiplegic Migraine

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28IUPHAR, 59Tocris Bioscience, 44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB
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Compounds related to Hemiplegic Migraine according to GeneCards/GeneDecks:

(show all 35)
idCompoundScoreTop Affiliating Genes
1aft-ii2810.3SCN5A, SCN1A
2bc-iii2810.3SCN5A, SCN1A
3ω-conotoxin mviic2810.3CACNA1A, CACNA1B
4atx-ii2810.3SCN5A, SCN1A
5batrachotoxin2810.2SCN5A, SCN1A
6qx 314 chloride5910.2SCN5A, SCN1A
7tetrodotoxin citrate5910.2SCN5A, SCN1A
8phrixotoxin 35910.2SCN5A, SCN1A
9veratridine44 59 2812.1SCN5A, SCN1A
10lithium carbonate5910.1ATP1B2, ATP1A2
11pb2+2810.1CACNA1B, CACNA1E
12tetrodotoxin44 59 2812.0CALCA, SCN5A, SCN1A
13loperamide44 11 2412.0OPRM1, CACNA1A
14(+-)-bay k 86445910.0CACNA1E, CACNA1A, CACNA1B
15nnc 55-0396 dihydrochloride599.9CACNA1E, CACNA1A, CACNA1B
16mibefradil dihydrochloride599.9CACNA1E, CACNA1A, CACNA1B
17omega-conotoxin gvia599.9CACNA1E, CACNA1A, CACNA1B
18pregabalin59 44 1111.9CACNA1E, CACNA1A, CACNA1B
19mibg449.9CACNA1B, CALCA
20anandamide44 28 59 2412.9CALCA, CACNA1B, OPRM1
21bepridil44 28 1111.9CACNA1A, DNAH8
22capsaicin44 2810.8OPRM1, CACNA1B, CALCA
23digoxin44 49 59 11 2413.7ATP1B2, ATP1A2, DNAH8
24ether449.7DNAH8, CALCA
25verapamil44 49 28 11 2413.5CACNA1A, CACNA1B, SCN5A, DNAH8
26clonidine44 28 1111.4CALCA, CACNA1B, OPRM1, DNAH8
27epinephrine44 11 2411.3DNAH8, OPRM1, CACNA1B, CALCA
285-hydroxytryptamine449.3CALCA, OPRM1, DNAH8
29norepinephrine44 11 2411.3DNAH8, OPRM1, CACNA1B, CALCA
30acetylcholine44 49 28 11 2413.2CALCA, CACNA1A, CACNA1B, OPRM1, DNAH8
31sodium44 2410.2CACNA1A, CACNA1B, SCN5A, SCN1A, ATP1B2, ATP1A2
32glutamate448.9CALCA, CACNA1A, CACNA1B, OPRM1, ATP1A2, DNAH8
33potassium44 11 2410.9ATP1A2, ATP1B2, OPRM1, SCN1A, SCN5A, CACNA1B
34glutamine448.9DNAH8, OPRM1, SCN5A, CACNA1A
35calcium44 49 11 2410.6CALCA, CACNA1E, CACNA1A, CACNA1B, SCN5A, OPRM1

GO Terms for genes affiliated with Hemiplegic Migraine

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16Gene Ontology
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Cellular components related to Hemiplegic Migraine according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1voltage-gated sodium channel complexGO:00151810.0SCN1A, SCN5A
2T-tubuleGO:0303159.8SCN5A, SCN1A, ATP1A2
3voltage-gated calcium channel complexGO:0058919.5CACNA1E, CACNA1A, CACNA1B
4sodium:potassium-exchanging ATPase complexGO:0058909.5ATP1A2, ATP1B2
5neuronal cell bodyGO:0430259.3CALCA, CACNA1A, CACNA1B, SCN1A
6plasma membraneGO:0058866.5NOTCH3, CACNA1E, CACNA1A, CACNA1B, GNB1, GNG2

Biological processes related to Hemiplegic Migraine according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1reduction of cytosolic calcium ion concentrationGO:05148110.0OPRM1, ATP1A2
2sodium ion transportGO:0068149.9ATP1A2, SCN1A, SCN5A
3regulation of cardiac muscle cell contractionGO:0860049.9SCN5A, ATP1A2
4response to painGO:0482659.8CACNA1B, CALCA
5regulation of blood pressureGO:0082179.8ATP1A2, CACNA1B, CALCA
6regulation of heart rateGO:0020279.8SCN5A, CACNA1E, CALCA
7behavioral response to painGO:0482669.6CACNA1A, CACNA1E
8membrane depolarizationGO:0518999.6SCN5A, CACNA1B, CACNA1A, CACNA1E
9locomotory behaviorGO:0076269.5OPRM1, CACNA1B, CACNA1E
10cellular response to catecholamine stimulusGO:0718709.2GNB1, GNG2
11cellular response to prostaglandin E stimulusGO:0713809.1GNB1, GNG2
12elevation of cytosolic calcium ion concentrationGO:0072049.1CALCA, CACNA1A, GNB1, OPRM1
13adenylate cyclase-activating dopamine receptor signaling pathwayGO:0071919.0OPRM1, GNG2, GNB1
14energy reserve metabolic processGO:0061128.7CACNA1E, CACNA1A, GNB1, GNG2
15synaptic transmissionGO:0072688.3CACNA1E, CACNA1A, CACNA1B, GNB1, GNG2

Molecular functions related to Hemiplegic Migraine according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1voltage-gated sodium channel activityGO:00524810.0SCN1A, SCN5A
2sodium:potassium-exchanging ATPase activityGO:0053919.7ATP1A2, ATP1B2
3voltage-gated calcium channel activityGO:0052459.2OPRM1, CACNA1B, CACNA1A, CACNA1E
4calcium ion bindingGO:0055098.4CACNA1E, CACNA1B, PRKCSH, HPCA, NOTCH3

Products for genes affiliated with Hemiplegic Migraine

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  • Antibodies
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Sources for Hemiplegic Migraine

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet