MCID: HMP006
MIFTS: 45

Hemiplegic Migraine malady

Categories: Rare diseases, Genetic diseases, Neuronal diseases

Aliases & Classifications for Hemiplegic Migraine

Aliases & Descriptions for Hemiplegic Migraine:

Name: Hemiplegic Migraine 50 69
Migraine Hemiplegic 52

Classifications:



Summaries for Hemiplegic Migraine

NIH Rare Diseases : 50 hemiplegic migraine (hm) is a rare type of migraine with aura that occurs with motor weakness during the aura. there are two types of hm which are distinguished based on the family history: familial hemiplegic migraine (fhm, in which at least one other family member has the condition) and sporadic hemiplegic migraine (shm, in which there is no family history). signs and symptoms vary but may include visual disturbances, sensory loss, difficulty with speech, weakness on one side of the body, confusion, and impaired consciousness. severe attacks may occur in both types with prolonged hemiplegia, coma, fever and/or seizures. fhm may be caused by a mutation in any of several genes and is inherited in an autosomal dominant manner. last updated: 11/17/2014

MalaCards based summary : Hemiplegic Migraine, also known as migraine hemiplegic, is related to familial hemiplegic migraine and sporadic hemiplegic migraine. An important gene associated with Hemiplegic Migraine is CACNA1A (Calcium Voltage-Gated Channel Subunit Alpha1 A), and among its related pathways/superpathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Vascular smooth muscle contraction. The drugs Topiramate and Anticonvulsants have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and trigeminal ganglion, and related phenotypes are Increased viability with SS1P at EC90 and behavior/neurological

Related Diseases for Hemiplegic Migraine

Diseases in the Hemiplegic Migraine family:

Migraine, Familial Hemiplegic, 2 Migraine, Familial Hemiplegic, 3
Migraine, Familial Hemiplegic, 1 Familial Hemiplegic Migraine
Sporadic Hemiplegic Migraine Familial or Sporadic Hemiplegic Migraine

Diseases related to Hemiplegic Migraine via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 62)
id Related Disease Score Top Affiliating Genes
1 familial hemiplegic migraine 12.7
2 sporadic hemiplegic migraine 12.5
3 familial or sporadic hemiplegic migraine 12.1
4 migraine, familial hemiplegic, 1 11.9
5 migraine, familial hemiplegic, 2 11.9
6 migraine, familial hemiplegic, 3 11.9
7 alternating hemiplegia of childhood 11.6
8 episodic ataxia 11.3
9 migraine with or without aura 1 11.0
10 alternating hemiplegia of childhood 2 11.0
11 hemiplegia alterans 11.0
12 ataxia 10.4
13 cerebritis 10.3
14 neuronitis 10.3
15 epilepsy 10.2
16 cerebellar ataxia 10.2
17 hemiplegia 10.2
18 encephalopathy 10.1
19 atrial fibrillation and stroke 10.1 ATP1A2 CACNA1A PRRT2 SCN1A
20 syphilitic spinal sclerosis 10.1 GNB1 PRRT2 SCN1A
21 placental abruption 10.1 ATP1A2 CACNA1A PRRT2
22 acro-pectoro-renal dysplasia 10.1 ATP1A2 CACNA1A PRRT2 SCN1A
23 ramsay hunt syndrome i 10.1 PRRT2 SLC2A1
24 infantile hypotonia 10.1 ATP1A2 CACNA1A CALCA SCN1A
25 myopathy mitochondrial cataract 10.1 SCN1A SLC2A1
26 tonoki syndrome 10.0 ATP1A2 ATP1B1 ATP1B2
27 glut1 deficiency syndrome 2 10.0 PRRT2 SLC2A1
28 cadasil 10.0
29 weber syndrome 10.0
30 moyamoya disease 10.0
31 migraine with aura 10.0
32 patent foramen ovale 9.9
33 episodic ataxia, type 2 9.9
34 retinitis 9.9
35 dystonia 9.9
36 retinal degeneration 9.9
37 meningitis 9.9
38 salpingo-oophoritis 9.9 ATP1A2 ATP1A3 CACNA1A CALCA SCN1A SLC2A1
39 interstitial emphysema 9.8 ATP1A2 CACNA1A KCNK18 NOTCH3 PRRT2
40 deafness, autosomal dominant 7 9.8 ATP1A2 ATP1A3 CACNA1A CALCA SLC2A1 XK
41 arteriovenous malformation 9.8
42 aseptic meningitis 9.8
43 hemicrania continua 9.8
44 pulmonary arteriovenous malformation 9.8
45 spastic paraparesis 9.8
46 status epilepticus 9.8
47 cystic fibrosis 9.8
48 ischemia 9.8
49 mood disorder 9.8
50 cerebral atrophy 9.8

Graphical network of the top 20 diseases related to Hemiplegic Migraine:



Diseases related to Hemiplegic Migraine

Symptoms & Phenotypes for Hemiplegic Migraine

GenomeRNAi Phenotypes related to Hemiplegic Migraine according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with SS1P at EC90 GR00376-A-1 8.8 ATP1A3 GNAI2 GNB1

MGI Mouse Phenotypes related to Hemiplegic Migraine:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.15 ATP1A2 ATP1A3 ATP1B2 CACNA1A GNAI2 GNB1
2 mortality/aging MP:0010768 10.13 PRKCSH SCN1A SCN5A SLC2A1 ATP1A2 ATP1A3
3 nervous system MP:0003631 10 KCNK18 NOTCH3 OPRM1 PRRT2 SCN1A SCN5A
4 muscle MP:0005369 9.8 ATP1B1 CACNA1A NOTCH3 SCN5A XK ATP1A2
5 normal MP:0002873 9.56 ATP1A2 ATP1B1 CACNA1A GNAI2 NOTCH3 OPRM1
6 respiratory system MP:0005388 9.17 ATP1A2 ATP1A3 ATP1B1 CACNA1A GNAI2 GNB1

Drugs & Therapeutics for Hemiplegic Migraine

Drugs for Hemiplegic Migraine (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Topiramate Approved Phase 2, Phase 3 97240-79-4 5284627
2 Anticonvulsants Phase 2, Phase 3
3 Anti-Obesity Agents Phase 2, Phase 3
4 Neuroprotective Agents Phase 2, Phase 3
5 Protective Agents Phase 2, Phase 3
6
Nitroglycerin Approved, Investigational 55-63-0 4510
7
Salmon Calcitonin Approved, Investigational 47931-85-1 16129616
8
Pancrelipase Approved 53608-75-6
9 Vasodilator Agents
10 Bone Density Conservation Agents
11 calcitonin
12 Calcitonin Gene-Related Peptide
13 pancreatin

Interventional clinical trials:


id Name Status NCT ID Phase
1 Dose Comparison Study of Topiramate in Pediatric Subjects With Basilar/Hemiplegic Migraine Completed NCT00131443 Phase 2, Phase 3
2 A Study of Topiramate in Pediatric Subjects With Basilar/Hemiplegic Migraine Completed NCT00158002 Phase 2
3 Glyceryl-Trinitrate-Induced Headache in Patients With Familial Hemiplegic Migraine Completed NCT00541736
4 Calcitonin Gene Related Peptide-Induced Headache in Patients With Familial Hemiplegic Migraine Type 1 and 2. Completed NCT00358839
5 Glyceryl-Trinitrate-Induced Headache in Patients With Familial Hemiplegic Migraine Type 1 and 2 Completed NCT00257985
6 Calcitonin Gene-related Peptide in Familial Hemiplegic Migraine (FHM) and Migraine With Aura (MA) Completed NCT00687947
7 Genetic Analysis of Children With Cyclic Vomiting Syndrome (CVS) and Migraines Recruiting NCT00727974

Search NIH Clinical Center for Hemiplegic Migraine

Genetic Tests for Hemiplegic Migraine

Anatomical Context for Hemiplegic Migraine

MalaCards organs/tissues related to Hemiplegic Migraine:

39
Brain, Testes, Trigeminal Ganglion, Tongue, Thalamus, Kidney, Cortex

Publications for Hemiplegic Migraine

Articles related to Hemiplegic Migraine:

(show top 50) (show all 396)
id Title Authors Year
1
Epilepsy in hemiplegic migraine: Genetic mutations and clinical implications. ( 28058944 )
2017
2
Inefficient constitutive inhibition of P2X3 receptors by brain natriuretic peptide system contributes to sensitization of trigeminal sensory neurons in a genetic mouse model of familial hemiplegic migraine. ( 27175010 )
2016
3
Defective glutamate and K+ clearance by cortical astrocytes in familial hemiplegic migraine type 2. ( 27354390 )
2016
4
Early-onset familial hemiplegic migraine due to a novel SCN1A mutation. ( 26763045 )
2016
5
Clinical and electroencephalographic abnormalities during the full duration of a sporadic hemiplegic migraine attack. ( 27155821 )
2016
6
Postoperative Hemiplegic Migraine After a Laparoscopic Cholecystectomy: A Case Report. ( 28045726 )
2016
7
A retrospective analysis of triptan and dhe use for basilar and hemiplegic migraine. ( 27062528 )
2016
8
Time course of downbeat positioning nystagmus in familial hemiplegic migraine type 1 treated with acetazolamide. ( 27538634 )
2016
9
Prevalence of lifetime depression in a large hemiplegic migraine cohort. ( 27807184 )
2016
10
Recurrent coma and fever in familial hemiplegic migraine type 2. A prospective 15-year follow-up of a large family with a novel ATP1A2 mutation. ( 27226003 )
2016
11
A novel SCN1A mutation identified in a Chinese family with familial hemiplegic migraine: A case report. ( 27919014 )
2016
12
Glutamate-system defects behind psychiatric manifestations in a familial hemiplegic migraine type 2 disease-mutation mouse model. ( 26911348 )
2016
13
Activity-dependent calcium, oxygen, and vascular responses in a mouse model of familial hemiplegic migraine type 1. ( 27314908 )
2016
14
Hemiplegic Migraine Presenting with Prolonged Somnolence: A Case Report. ( 27790126 )
2016
15
Hemiplegic migraine and late-onset photosensitive epileptic seizures. ( 27406575 )
2016
16
Familial Hemiplegic Migraine with Severe Attacks: A New Report with ATP1A2 Mutation. ( 27818813 )
2016
17
Loss of inhibition by brain natriuretic peptide over P2X3 receptors contributes to enhanced spike firing of trigeminal ganglion neurons in a mouse model of familial hemiplegic migraine type-1. ( 27346147 )
2016
18
Familial hemiplegic migraine type-1 mutated cav2.1 calcium channels alter inhibitory and excitatory synaptic transmission in the lateral superior olive of mice. ( 25481823 )
2015
19
Abnormal cortical synaptic transmission in CaV2.1 knockin mice with the S218L missense mutation which causes a severe familial hemiplegic migraine syndrome in humans. ( 25741235 )
2015
20
CAPOS syndrome and hemiplegic migraine in a novel pedigree with the specific ATP1A3 mutation. ( 26453127 )
2015
21
Concordant Occipital and Supraorbital Neurostimulation Therapy for Hemiplegic Migraine; Initial Experience; A Case Series. ( 25688595 )
2015
22
A case report of sporadic hemiplegic migraine associated cerebral hypoperfusion: comparison of arterial spin labeling and dynamic susceptibility contrast perfusion MR imaging. ( 26250760 )
2015
23
Biphasic neurovascular changes in prolonged migraine aura in familial hemiplegic migraine type 2. ( 25411546 )
2015
24
Novel frameshift mutation in the CACNA1A gene causing a mixed phenotype of episodic ataxia and familiar hemiplegic migraine. ( 25468264 )
2015
25
Perfusion and pH MRI in familial hemiplegic migraine with prolonged aura. ( 25948653 )
2015
26
Stress hormone corticosterone enhances susceptibility to cortical spreading depression in familial hemiplegic migraine type 1 mutant mice. ( 25447936 )
2015
27
Plasma metabolic profiling after cortical spreading depression in a transgenic mouse model of hemiplegic migraine by capillary electrophoresis - mass spectrometry. ( 25856790 )
2015
28
Familial Hemiplegic Migraine and Recurrent Episodes of Psychosis: A Case Report. ( 26087244 )
2015
29
Abnormal synaptic Ca(2+) homeostasis and morphology in cortical neurons of familial hemiplegic migraine type 1 mutant mice. ( 26032020 )
2015
30
Familial hemiplegic migraine type 1 associated with parkinsonism: a case report. ( 25969684 )
2015
31
Sporadic hemiplegic migraine and giant tumefactive perivascular space: Is there an association? ( 26696413 )
2015
32
An altered GABA-A receptor function in spinocerebellar ataxia type 6 and familial hemiplegic migraine type 1 associated with the CACNA1A gene mutation. ( 26675662 )
2014
33
Familial hemiplegic migraine treated by sodium valproate and lamotrigine. ( 24443394 )
2014
34
A novel ATP1A2 gene mutation in familial hemiplegic migraine and epilepsy. ( 23918834 )
2014
35
Two novel SCN1A mutations identified in families with familial hemiplegic migraine. ( 24707016 )
2014
36
Pharmacological Correction of Gating Defects in the Voltage-Gated Cav2.1 Ca(2+) Channel due to a Familial Hemiplegic Migraine Mutation. ( 24411734 )
2014
37
A novel SLC2A1 mutation linking hemiplegic migraine with alternating hemiplegia of childhood. ( 24824604 )
2014
38
Repeated encephalopathy and hemicerebral atrophy in a patient with familial hemiplegic migraine type 1. ( 25274239 )
2014
39
A hyperexcitability phenotype in mouse trigeminal sensory neurons expressing the R192Q Cacna1a missense mutation of familial hemiplegic migraine type-1. ( 24583041 )
2014
40
Hemiplegic migraine: neuroimaging findings during a hemiplegic migraine attack. ( 24512003 )
2014
41
Familial hemiplegic migraine due to L263V SCN1A mutation: Discordance for epilepsy between two kindreds from Douro Valley. ( 24646837 )
2014
42
Sturge-Weber syndrome with late onset hemiplegic migraine-like attacks and progressive unilateral cerebral atrophy. ( 24045571 )
2014
43
Functional analysis of human Na(+)/K(+)-ATPase familial or sporadic hemiplegic migraine mutations expressed in Xenopus oocytes. ( 24921013 )
2014
44
Synaptic gain-of-function effects of mutant Cav2.1 channels in a mouse model of familial hemiplegic migraine are due to increased basal [Ca2+]i. ( 24849341 )
2014
45
Familial hemiplegic migraine: A model for the genetic studies of migraine. ( 24707017 )
2014
46
PRRT2 and hemiplegic migraine: a complex association. ( 24928127 )
2014
47
Arterial surgery for sporadic hemiplegic migraine: preliminary results. ( 24703384 )
2014
48
The prevalence of familial hemiplegic migraine with cerebellar ataxia and spinocerebellar ataxia type 6 in Portugal. ( 24898624 )
2014
49
Hemiplegic migraine: An atypical presentation of Moyamoya disease. ( 25538508 )
2014
50
Biochemical changes in the brain of hemiplegic migraine patients measured with 7 tesla 1H-MRS. ( 24651393 )
2014

Variations for Hemiplegic Migraine

Expression for Hemiplegic Migraine

Search GEO for disease gene expression data for Hemiplegic Migraine.

Pathways for Hemiplegic Migraine

Pathways related to Hemiplegic Migraine according to GeneCards Suite gene sharing:

(show all 36)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.34 ATP1A2 ATP1A3 ATP1B1 ATP1B2 GNB1 GNG2
2
Show member pathways
12.86 ATP1A2 ATP1A3 ATP1B1 ATP1B2 GNAI2 SCN5A
3
Show member pathways
12.84 CACNA1A GNAI2 GNB1 GNG2 SCN1A SCN5A
4
Show member pathways
12.73 ATP1A2 ATP1A3 ATP1B1 ATP1B2 KCNK18 SCN1A
5
Show member pathways
12.72 CACNA1A GNAI2 GNB1 GNG2 SCN1A
6
Show member pathways
12.59 ATP1A2 ATP1A3 ATP1B1 ATP1B2 SCN1A SCN5A
7
Show member pathways
12.54 CACNA1A GNAI2 GNB1 GNG2 OPRM1
8 12.51 CALCA NOTCH3 OPRM1 SCN1A SCN5A
9
Show member pathways
12.47 ATP1A2 ATP1A3 ATP1B1 ATP1B2
10
Show member pathways
12.35 ATP1A2 ATP1A3 ATP1B1 ATP1B2 SLC2A1
11 12.31 CACNA1A GNAI2 GNB1 GNG2
12
Show member pathways
12.3 CACNA1A GNAI2 GNB1 GNG2 SLC2A1
13
Show member pathways
12.29 ATP1B1 ATP1B2 CACNA1A CALCA GNAI2 GNB1
14
Show member pathways
12.21 ATP1A2 ATP1A3 ATP1B1 ATP1B2 GNAI2
15
Show member pathways
12.17 GNAI2 GNB1 GNG2 SLC2A1
16
Show member pathways
12.09 ATP1A2 ATP1A3 ATP1B1 ATP1B2 GNAI2
17 12.08 CALCA GNAI2 GNB1 GNG2
18 12.03 GNAI2 GNB1 GNG2 NOTCH3
19
Show member pathways
11.98 ATP1A2 ATP1A3 ATP1B1 ATP1B2
20 11.92 CACNA1A GNAI2 GNB1 GNG2
21 11.83 ATP1A2 ATP1A3 ATP1B1 ATP1B2
22
Show member pathways
11.8 GNAI2 GNB1 GNG2
23 11.69 ATP1A2 ATP1A3 ATP1B1 ATP1B2
24 11.66 GNAI2 GNB1 GNG2
25 11.63 GNAI2 GNB1 GNG2
26 11.46 GNAI2 GNB1 GNG2
27 11.44 ATP1A2 ATP1A3 ATP1B1 ATP1B2
28 11.38 ATP1A2 ATP1A3 ATP1B1 ATP1B2
29 11.31 ATP1A2 ATP1A3 ATP1B1 ATP1B2
30 11.28 GNAI2 GNB1 GNG2
31 11.2 ATP1A2 ATP1A3 ATP1B1 ATP1B2 SLC2A1
32 11.19 ATP1A2 ATP1A3 ATP1B1 ATP1B2
33 11.16 ATP1A2 ATP1A3 ATP1B1 ATP1B2 NOTCH3 SLC2A1
34 10.92 GNB1 GNG2
35 10.82 ATP1A2 ATP1A3 ATP1B1 ATP1B2
36 10.48 GNB1 GNG2

GO Terms for Hemiplegic Migraine

Cellular components related to Hemiplegic Migraine according to GeneCards Suite gene sharing:

(show all 13)
id Name GO ID Score Top Affiliating Genes
1 axon GO:0030424 9.81 ATP1A3 CALCA OPRM1 SCN1A
2 myelin sheath GO:0043209 9.76 ATP1A2 ATP1A3 ATP1B1 GNB1
3 caveola GO:0005901 9.67 ATP1A2 ATP1B1 SCN5A SLC2A1
4 intercalated disc GO:0014704 9.62 ATP1A2 ATP1B1 SCN1A SCN5A
5 T-tubule GO:0030315 9.61 ATP1A2 SCN1A SCN5A
6 heterotrimeric G-protein complex GO:0005834 9.58 GNAI2 GNB1 GNG2
7 sarcolemma GO:0042383 9.55 ATP1A2 ATP1A3 ATP1B1 OPRM1 SCN5A
8 voltage-gated sodium channel complex GO:0001518 9.49 SCN1A SCN5A
9 extracellular vesicle GO:1903561 9.35 ATP1A2 ATP1A3 ATP1B1 GNAI2 GNB1
10 sodium:potassium-exchanging ATPase complex GO:0005890 8.92 ATP1A2 ATP1A3 ATP1B1 ATP1B2
11 membrane GO:0016020 10.38 ATP1A2 ATP1A3 ATP1B1 ATP1B2 CACNA1A GNAI2
12 integral component of membrane GO:0016021 10.34 ATP1A2 ATP1A3 ATP1B1 ATP1B2 CACNA1A KCNK18
13 plasma membrane GO:0005886 10.16 ATP1A2 ATP1A3 ATP1B1 ATP1B2 CACNA1A GNAI2

Biological processes related to Hemiplegic Migraine according to GeneCards Suite gene sharing:

(show all 34)
id Name GO ID Score Top Affiliating Genes
1 ion transmembrane transport GO:0034220 9.97 ATP1A2 ATP1A3 ATP1B1 ATP1B2 SCN1A SCN5A
2 potassium ion transport GO:0006813 9.93 ATP1A2 ATP1A3 ATP1B1 ATP1B2 KCNK18
3 regulation of ion transmembrane transport GO:0034765 9.91 CACNA1A KCNK18 SCN1A SCN5A
4 protein folding GO:0006457 9.91 GNAI2 GNB1 GNG2 PRKCSH
5 sodium ion transport GO:0006814 9.88 ATP1A2 ATP1A3 ATP1B1 ATP1B2 SCN1A SCN5A
6 regulation of cardiac conduction GO:1903779 9.85 ATP1A2 ATP1A3 ATP1B1 ATP1B2
7 cellular calcium ion homeostasis GO:0006874 9.83 ATP1B1 CALCA XK
8 cardiac muscle contraction GO:0060048 9.78 ATP1A2 ATP1A3 ATP1B1 SCN5A
9 membrane depolarization during action potential GO:0086010 9.74 CACNA1A SCN1A SCN5A
10 potassium ion import GO:0010107 9.73 ATP1A2 ATP1A3 ATP1B1 ATP1B2
11 adenylate cyclase-activating dopamine receptor signaling pathway GO:0007191 9.7 GNB1 GNG2 OPRM1
12 membrane repolarization GO:0086009 9.69 ATP1A2 ATP1B1 ATP1B2
13 cellular sodium ion homeostasis GO:0006883 9.67 ATP1A2 ATP1A3 ATP1B1 ATP1B2
14 cellular response to prostaglandin E stimulus GO:0071380 9.66 GNB1 GNG2
15 cardiac muscle cell action potential involved in contraction GO:0086002 9.66 SCN1A SCN5A
16 G-protein coupled acetylcholine receptor signaling pathway GO:0007213 9.65 GNAI2 GNB1
17 neuromuscular process controlling posture GO:0050884 9.65 PRRT2 SCN1A
18 regulation of cardiac muscle cell contraction GO:0086004 9.64 ATP1A2 SCN5A
19 relaxation of cardiac muscle GO:0055119 9.64 ATP1A2 ATP1B1
20 membrane depolarization during cardiac muscle cell action potential GO:0086012 9.63 ATP1A2 SCN5A
21 cellular response to steroid hormone stimulus GO:0071383 9.63 ATP1A2 ATP1A3
22 potassium ion import across plasma membrane GO:1990573 9.62 ATP1A2 ATP1B1
23 cellular response to catecholamine stimulus GO:0071870 9.62 GNB1 GNG2
24 cell communication by electrical coupling involved in cardiac conduction GO:0086064 9.62 ATP1A2 ATP1A3 ATP1B1 ATP1B2
25 positive regulation of potassium ion transmembrane transporter activity GO:1901018 9.6 ATP1B1 ATP1B2
26 response to glycoside GO:1903416 9.59 ATP1A2 ATP1A3
27 positive regulation of sodium ion export from cell GO:1903278 9.58 ATP1B1 ATP1B2
28 positive regulation of potassium ion import GO:1903288 9.58 ATP1B1 ATP1B2
29 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.56 ATP1A2 ATP1A3 ATP1B1 ATP1B2
30 cellular potassium ion homeostasis GO:0030007 9.46 ATP1A2 ATP1A3 ATP1B1 ATP1B2
31 ATP hydrolysis coupled transmembrane transport GO:0090662 9.26 ATP1A2 ATP1A3 ATP1B1 ATP1B2
32 sodium ion export from cell GO:0036376 8.92 ATP1A2 ATP1A3 ATP1B1 ATP1B2
33 transport GO:0006810 10.26 ATP1A2 ATP1A3 ATP1B1 ATP1B2 CACNA1A KCNK18
34 ion transport GO:0006811 10.06 ATP1A2 ATP1A3 ATP1B1 ATP1B2 CACNA1A KCNK18

Molecular functions related to Hemiplegic Migraine according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 ion channel activity GO:0005216 9.54 CACNA1A SCN1A SCN5A
2 potassium ion binding GO:0030955 9.32 ATP1A2 ATP1B1
3 sodium ion binding GO:0031402 9.26 ATP1A2 ATP1B1
4 G-protein beta-subunit binding GO:0031681 9.16 GNG2 OPRM1
5 steroid hormone binding GO:1990239 8.96 ATP1A2 ATP1A3
6 sodium:potassium-exchanging ATPase activity GO:0005391 8.92 ATP1A2 ATP1A3 ATP1B1 ATP1B2

Sources for Hemiplegic Migraine

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
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30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
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70 UMLS via Orphanet
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