MCID: HMP006
MIFTS: 44

Hemiplegic Migraine malady

Summaries for Hemiplegic Migraine

Sources:
43NIH Rare Diseases, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Hemiplegic migraine refers to migraine with aura accompanied with motor weakness. signs and symptoms vary but may include visual disturbance, sensory loss, difficulty with speech, weakness on one side of the body, confusion, and impaired consciousness. frequency of hemiplegic migraine can vary considerably. it can take time for symptoms to resolve, but permanent motor, sensory, language, or visual symptoms are extremely rare. it can occur as a sporadic or genetic disorder. when inherited, it is passed through families in an autosomal dominant fashion. last updated: 8/26/2013

MalaCards: Hemiplegic Migraine, also known as migraine hemiplegic, is related to familial hemiplegic migraine and alternating hemiplegia of childhood. An important gene associated with Hemiplegic Migraine is CACNA1A (calcium channel, voltage-dependent, P/Q type, alpha 1A subunit), and among its related pathways are Adrenoceptors and Proximal tubule bicarbonate reclamation. The compounds aft-ii and bc-iii have been mentioned in the context of this disorder. Affiliated tissues include tongue, brain and kidney, and related mouse phenotypes are normal and homeostasis/metabolism.

Wikipedia:64 Familial hemiplegic migraine (FHM) is an autosomal dominant classical migraine subtype that typically... more...

Aliases & Classifications for Hemiplegic Migraine

Sources:
43NIH Rare Diseases, 61UMLS, 45Novoseek
See all sources

Aliases & Descriptions:

hemiplegic migraine 43 61
migraine hemiplegic 45


Related Diseases for Hemiplegic Migraine

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the familial hemiplegic migraine type 1 family:

familial hemiplegic migraine familial hemiplegic migraine type 2
familial hemiplegic migraine type 3 hemiplegic migraine

Diseases related to Hemiplegic Migraine via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 53)
idRelated DiseaseScoreTop Affiliating Genes
1familial hemiplegic migraine31.9NOTCH3, ATP1A2, SCN1A, CACNA1A, DNAH8
2alternating hemiplegia of childhood30.5ATP1A2
3familial hemiplegic migraine type 110.7
4ataxia10.7
5familial hemiplegic migraine type 210.7
6familial hemiplegic migraine type 310.7
7episodic ataxia10.6
8basilar migraine10.4
9cadasil10.4
10sturge-weber syndrome10.4
11weber syndrome10.4
12paroxysmal dyskinesia10.4
13moyamoya disease10.3
14patent foramen ovale10.3
15n syndrome10.3
16mental retardation10.3
17migraine, familial basilar10.3
18mitral valve prolapse10.1
19cystic fibrosis10.1
20status epilepticus10.1
21erdheim-chester disease10.1
22arteriovenous malformation10.1
23spinocerebellar ataxia10.1
24pulmonary arteriovenous malformation10.1
25familial deafness10.1
26familial hypertension10.1
27torticollis, familial10.1
28hemicrania continua10.1
29progressive hemifacial atrophy10.1
30spastic paraparesis10.1
31cerebral atrophy10.1
32febrile seizures10.1
33headache10.1
34hemiplegia alterans10.1
35seizure disorder10.1
36tremor10.1
37blindness10.1
38episodic ataxia type 210.0CACNA1A
39benign familial infantile epilepsy10.0ATP1A2
40spinocerebellar ataxia type 610.0CACNA1A
41hemiplegia10.0CACNA1A, ATP1A2
42migraine with aura10.0CACNA1E
43migraine without aura10.0CACNA1E
44idiopathic generalized epilepsy10.0SCN1A, CACNA1A
45diabetes mellitus10.0CALCA, DNAH8
46cholera10.0CALCA, DNAH8
47ischemia10.0DNAH8, SCN5A, ATP1A2
48essential hypertension10.0CACNA1B
49amnestic disorder10.0OPRM1, DNAH8
50hypertension10.0DNAH8, CALCA

Graphical network of the top 20 diseases related to Hemiplegic Migraine:



Diseases related to hemiplegic migraine

Clinical Features for Hemiplegic Migraine

Drugs & Therapeutics for Hemiplegic Migraine

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Hemiplegic Migraine

Drug clinical trials:

Search ClinicalTrials for Hemiplegic Migraine

Search NIH Clinical Center for Hemiplegic Migraine

Search CenterWatch for Hemiplegic Migraine

Genetic Tests for Hemiplegic Migraine

Anatomical Context for Hemiplegic Migraine

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Hemiplegic Migraine:

33
Tongue, Brain, Kidney, Cortex, Cerebellum, Thalamus, Trigeminal ganglion

Animal Models for Hemiplegic Migraine or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Hemiplegic Migraine

Sources:
51PubMed
See all sources

Articles related to Hemiplegic Migraine:

(show top 50)    (show all 344)
idTitleAuthorsYear
1
Sporadic hemiplegic migraine with permanent neurological deficits. (24117121)
2014
2
Pulmonary arterial hypertension in familial hemiplegic migraine with ATP1A2 channelopathy. (24136331)
2013
3
Familial and sporadic hemiplegic migraine: diagnosis and treatment. (23203776)
2013
4
Cerebellar ataxia, hemiplegic migraine, and related phenotypes due to a CACNA1A missense mutation: 12-year follow-up of a large Portuguese family. (23407676)
2013
5
Acute encephalopathy in familial hemiplegic migraine with ATP1A2 mutation. (23761507)
2013
6
The familial hemiplegic migraine type 1 mutation K1336E affects direct G protein-mediated regulation of neuronal P/Q-type Ca2+ channels. (23430985)
2013
7
Familial hemiplegic migraine type 1 mutations W1684R and V1696I alter G protein-mediated regulation of Ca(V)2.1 voltage-gated calcium channels. (22549042)
2012
8
Sporadic hemiplegic migraine. (22410518)
2012
9
Sporadic hemiplegic migraine with normal imaging as the initial manifestation of CADASIL. (22250206)
2012
10
Increased susceptibility to cortical spreading depression in the mouse model of familial hemiplegic migraine type 2. (21731499)
2011
11
Multimodal neuroimaging in a child with sporadic hemiplegic migraine: a contribution to understanding pathogenesis. (21172953)
2011
12
De novo mutations in ATP1A2 and CACNA1A are frequent in early-onset sporadic hemiplegic migraine. (20837964)
2010
13
Moyamoya disease presented as a case of hemiplegic migraine. (22798438)
2010
14
Severe and progressive neurotransmitter release aberrations in familial hemiplegic migraine type 1 Cacna1a S218L knock-in mice. (20631222)
2010
15
A case of atypical sporadic hemiplegic migraine associated with PFO and hypoplasia of vertebro-basilar system. (19421707)
2009
16
Diverse functional consequences of mutations in the Na+/K+-ATPase alpha2-subunit causing familial hemiplegic migraine type 2. (18728015)
2008
17
Familial hemiplegic migraine resulting in recurrent coma]. (18380388)
2008
18
Familial hemiplegic migraine type 2 does not share hypersensitivity to nitric oxide with common types of migraine. (18294248)
2008
19
Expansion of the phenotypic spectrum of the CACNA1A T666M mutation: a family with familial hemiplegic migraine type 1, cerebellar atrophy and mental retardation. (18279427)
2008
20
Amino acid changes in the amino terminus of the Na,K-adenosine triphosphatase alpha-2 subunit associated to familial and sporadic hemiplegic migraine. (17877748)
2007
21
ATP1A2 mutations in 11 families with familial hemiplegic migraine. (16088919)
2005
22
Familial hemiplegic migraine, neuropsychiatric symptoms, and Erdheim-Chester disease. (15447701)
2004
23
Functional effects of Na+,K+-ATPase gene mutations linked to familial hemiplegic migraine. (15970628)
2004
24
Kinetic alterations due to a missense mutation in the Na,K-ATPase alpha2 subunit cause familial hemiplegic migraine type 2. (15308625)
2004
25
Serial MRI in a case of familial hemiplegic migraine. (12669159)
2003
26
Treatment of sporadic hemiplegic migraine with calcium-channel blocker verapamil. (12963781)
2003
27
Haploinsufficiency of ATP1A2 encoding the Na+/K+ pump alpha2 subunit associated with familial hemiplegic migraine type 2. (12539047)
2003
28
Expanding the phenotypic spectrum of the CACNA1A gene T666M mutation: a description of 5 families with familial hemiplegic migraine. (12756131)
2003
29
Familial hemiplegic migraine type 2 is linked to 0.9Mb region on chromosome 1q23. (12601705)
2003
30
Mutation analysis of the CACNA1A calcium channel subunit gene in 27 patients with sporadic hemiplegic migraine. (12056940)
2002
31
Multimodal functional imaging of prolonged neurological deficits in a patient suffering from familial hemiplegic migraine. (12384224)
2002
32
A population-based study of familial hemiplegic migraine suggests revised diagnostic criteria. (12023326)
2002
33
Migraine with aura susceptibility locus on chromosome 19p13 is distinct from the familial hemiplegic migraine locus. (11735221)
2001
34
Hemiplegic migraine--downstream of a single-base change. (11439951)
2001
35
Hemiplegic migraine during pregnancy: unusual magnetic resonance appearance with SPECT scan correlation. (11264693)
2001
36
Sporadic hemiplegic migraine and Sturge-Weber syndrome. (11251712)
2001
37
Familial hemiplegic migraine with cerebellar ataxia and paroxysmal psychosis. (10202246)
1999
38
Familial hemiplegic migraine: involvement of a calcium neuronal channel. (9436352)
1997
39
Families linked and unlinked to chromosome 19 with familial hemiplegic migraine. (8734764)
1996
40
Familial hemiplegic migraine: a clinical comparison of families linked and unlinked to chromosome 19.DMG RG. (8734765)
1996
41
A 3-Mb region for the familial hemiplegic migraine locus on 19p13.1- p13.2: exclusion of PRKCSH as a candidate gene. (9043864)
1996
42
Familial hemiplegic migraine locus on 19p13 is involved in the common forms of migraine with and without aura. (8530012)
1995
43
Familial Hemiplegic Migraine (20301562)
1993
44
Hemiplegic migraine following third molar extractions under intravenous sedation: report of a case. (2913255)
1989
45
Familial hemiplegic migraine: a new case. (3818262)
1986
46
Cerebral hemodynamics in familial hemiplegic migraine. (7346179)
1981
47
Clinical aspects of familial hemiplegic migraine in two families. (7309446)
1981
48
Familial hemiplegic migraine: EEG and CT scan study of two cases. (7316492)
1981
49
Familial hemiplegic migraine. (13854572)
1960
50
Hemiplegic migraine. (13489617)
1958

Genetic Variations for Hemiplegic Migraine

Expression for genes affiliated with Hemiplegic Migraine

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Hemiplegic Migraine

Search GEO for disease gene expression data for Hemiplegic Migraine.

Pathways for genes affiliated with Hemiplegic Migraine

Sources:
54Reactome, 50PharmGKB, 30KEGG, 12EMD Millipore, 38NCBI BioSystems Database, 52QIAGEN
See all sources

Pathways related to Hemiplegic Migraine according to GeneCards/GeneDecks:

(show all 36)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.9CACNA1B, CACNA1A
29.8ATP1A2, ATP1B2
39.8ATP1B2, ATP1A2
4
Hide members
9.7ATP1A2, CACNA1B, CACNA1A
5
Hide members
9.5CACNA1E, CACNA1A, CACNA1B
69.5CACNA1B, CACNA1A, CACNA1E
7
Hide members
9.5CACNA1B, CACNA1A, CACNA1E
8
Development Ligand-independent activation of ESR1 and ESR2
Hide members
9.5CACNA1B, CACNA1A, CACNA1E
99.5CACNA1E, CACNA1A, CACNA1B
109.5CACNA1B, CACNA1A, CACNA1E
119.5CACNA1E, CACNA1A, CACNA1B
129.5CACNA1E, CACNA1A, CACNA1B
13
Hide members
9.5CACNA1B, ATP1B2, ATP1A2
14
Hide members
9.3SCN5A, SCN1A, ATP1B2, ATP1A2
159.3CACNA1E, CACNA1A, CACNA1B, SCN1A
169.3NOTCH3, CACNA1B, CACNA1A, CACNA1E
17
Hide members
9.1GNB1, CACNA1B, CACNA1A
189.0GNG2, GNB1
19
Hide members
8.5CACNA1A, CACNA1B, GNB1, GNG2
20
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8.4CALCA, GNB1, GNG2, OPRM1
21
Hide members
8.4CACNA1E, CACNA1A, GNB1, GNG2
22
Hide members
8.4CACNA1B, GNB1, GNG2, OPRM1
23
Hide members
8.1CACNA1E, CACNA1A, CACNA1B, GNB1, GNG2
24
Hide members
8.1CACNA1E, CACNA1A, CACNA1B, GNB1, GNG2
25
Hide members
8.1CACNA1E, CACNA1A, CACNA1B, GNB1, GNG2
26
Hide members
8.1GNG2, GNB1, CACNA1B, CACNA1A, CACNA1E
27
Hide members
8.1CACNA1E, CACNA1A, CACNA1B, GNB1, GNG2
28
Hide members
8.1GNG2, GNB1, CACNA1B, CACNA1A, CACNA1E
29
Hide members
8.1CACNA1E, CACNA1A, CACNA1B, GNB1, GNG2
30
Hide members
8.1GNG2, GNB1, CACNA1B, CACNA1A, CACNA1E
318.1CACNA1E, CACNA1A, CACNA1B, GNB1, GNG2
32
Hide members
7.9CACNA1A, CACNA1B, GNB1, GNG2, SCN1A, OPRM1
33
Hide members
7.9NOTCH3, GNG2, GNB1, CACNA1B, CACNA1A, CACNA1E
34
Hide members
7.6CACNA1E, CACNA1A, CACNA1B, GNB1, GNG2, SCN5A
35
Hide members
7.6CACNA1E, CACNA1A, CACNA1B, GNB1, GNG2, SCN5A
36
Hide members
7.4ATP1B2, CALCA, CACNA1E, CACNA1A, CACNA1B, GNB1

Compounds for genes affiliated with Hemiplegic Migraine

Sources:
29IUPHAR, 60Tocris Bioscience, 45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB
See all sources

Compounds related to Hemiplegic Migraine according to GeneCards/GeneDecks:

(show all 35)
idCompoundScoreTop Affiliating Genes
1aft-ii2910.3SCN5A, SCN1A
2bc-iii2910.3SCN5A, SCN1A
3ω-conotoxin mviic2910.3CACNA1A, CACNA1B
4atx-ii2910.3SCN5A, SCN1A
5batrachotoxin2910.2SCN5A, SCN1A
6qx 314 chloride6010.2SCN5A, SCN1A
7tetrodotoxin citrate6010.2SCN5A, SCN1A
8phrixotoxin 36010.2SCN5A, SCN1A
9veratridine45 60 2912.1SCN5A, SCN1A
10lithium carbonate6010.1ATP1B2, ATP1A2
11pb2+2910.1CACNA1B, CACNA1E
12tetrodotoxin45 60 2912.0CALCA, SCN5A, SCN1A
13loperamide45 11 2412.0OPRM1, CACNA1A
14(+-)-bay k 86446010.0CACNA1E, CACNA1A, CACNA1B
15nnc 55-0396 dihydrochloride609.9CACNA1E, CACNA1A, CACNA1B
16mibefradil dihydrochloride609.9CACNA1E, CACNA1A, CACNA1B
17omega-conotoxin gvia609.9CACNA1E, CACNA1A, CACNA1B
18pregabalin60 45 1111.9CACNA1E, CACNA1A, CACNA1B
19mibg459.9CACNA1B, CALCA
20anandamide45 29 60 2412.9CALCA, CACNA1B, OPRM1
21bepridil45 29 1111.9CACNA1A, DNAH8
22capsaicin45 2910.8OPRM1, CACNA1B, CALCA
23digoxin45 50 60 11 2413.7ATP1B2, ATP1A2, DNAH8
24ether459.7DNAH8, CALCA
25verapamil45 50 29 11 2413.5CACNA1A, CACNA1B, SCN5A, DNAH8
26clonidine45 29 1111.4CALCA, CACNA1B, OPRM1, DNAH8
27epinephrine45 11 2411.3DNAH8, OPRM1, CACNA1B, CALCA
285-hydroxytryptamine459.3CALCA, OPRM1, DNAH8
29norepinephrine45 11 2411.3DNAH8, OPRM1, CACNA1B, CALCA
30acetylcholine45 50 29 11 2413.2CALCA, CACNA1A, CACNA1B, OPRM1, DNAH8
31sodium45 2410.2CACNA1A, CACNA1B, SCN5A, SCN1A, ATP1B2, ATP1A2
32glutamate458.9CALCA, CACNA1A, CACNA1B, OPRM1, ATP1A2, DNAH8
33potassium45 11 2410.9ATP1A2, ATP1B2, OPRM1, SCN1A, SCN5A, CACNA1B
34glutamine458.9DNAH8, OPRM1, SCN5A, CACNA1A
35calcium45 50 11 2410.6CALCA, CACNA1E, CACNA1A, CACNA1B, SCN5A, OPRM1

GO Terms for genes affiliated with Hemiplegic Migraine

Sources:
16Gene Ontology
See all sources

Cellular components related to Hemiplegic Migraine according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1voltage-gated sodium channel complexGO:00151810.0SCN1A, SCN5A
2T-tubuleGO:0303159.8SCN5A, SCN1A, ATP1A2
3voltage-gated calcium channel complexGO:0058919.5CACNA1E, CACNA1A, CACNA1B
4sodium:potassium-exchanging ATPase complexGO:0058909.5ATP1A2, ATP1B2
5neuronal cell bodyGO:0430259.3CALCA, CACNA1A, CACNA1B, SCN1A
6plasma membraneGO:0058866.5NOTCH3, CACNA1E, CACNA1A, CACNA1B, GNB1, GNG2

Biological processes related to Hemiplegic Migraine according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1reduction of cytosolic calcium ion concentrationGO:05148110.0OPRM1, ATP1A2
2sodium ion transportGO:0068149.9ATP1A2, SCN1A, SCN5A
3regulation of cardiac muscle cell contractionGO:0860049.9SCN5A, ATP1A2
4response to painGO:0482659.8CACNA1B, CALCA
5regulation of blood pressureGO:0082179.8ATP1A2, CACNA1B, CALCA
6regulation of heart rateGO:0020279.8SCN5A, CACNA1E, CALCA
7behavioral response to painGO:0482669.6CACNA1A, CACNA1E
8membrane depolarizationGO:0518999.6SCN5A, CACNA1B, CACNA1A, CACNA1E
9locomotory behaviorGO:0076269.5OPRM1, CACNA1B, CACNA1E
10cellular response to catecholamine stimulusGO:0718709.2GNB1, GNG2
11cellular response to prostaglandin E stimulusGO:0713809.1GNB1, GNG2
12elevation of cytosolic calcium ion concentrationGO:0072049.1CALCA, CACNA1A, GNB1, OPRM1
13adenylate cyclase-activating dopamine receptor signaling pathwayGO:0071919.0OPRM1, GNG2, GNB1
14energy reserve metabolic processGO:0061128.7CACNA1E, CACNA1A, GNB1, GNG2
15synaptic transmissionGO:0072688.3CACNA1E, CACNA1A, CACNA1B, GNB1, GNG2

Molecular functions related to Hemiplegic Migraine according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1voltage-gated sodium channel activityGO:00524810.0SCN1A, SCN5A
2sodium:potassium-exchanging ATPase activityGO:0053919.7ATP1A2, ATP1B2
3voltage-gated calcium channel activityGO:0052459.2OPRM1, CACNA1B, CACNA1A, CACNA1E
4calcium ion bindingGO:0055098.4CACNA1E, CACNA1B, PRKCSH, HPCA, NOTCH3

Products for genes affiliated with Hemiplegic Migraine

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Sources for Hemiplegic Migraine

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet