MCID: HMP006
MIFTS: 45

Hemiplegic Migraine malady

Categories: Genetic diseases, Rare diseases, Neuronal diseases

Aliases & Classifications for Hemiplegic Migraine

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Aliases & Descriptions for Hemiplegic Migraine:

Name: Hemiplegic Migraine 48 68
 
Migraine Hemiplegic 50

Classifications:



Summaries for Hemiplegic Migraine

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NIH Rare Diseases:48 Hemiplegic migraine (hm) is a rare type of migraine with aura that occurs with motor weakness during the aura. there are two types of hm which are distinguished based on the family history: familial hemiplegic migraine (fhm, in which at least one other family member has the condition) and sporadic hemiplegic migraine (shm, in which there is no family history). signs and symptoms vary but may include visual disturbances, sensory loss, difficulty with speech, weakness on one side of the body, confusion, and impaired consciousness. severe attacks may occur in both types with prolonged hemiplegia, coma, fever and/or seizures. fhm may be caused by a mutation in any of several genes and is inherited in an autosomal dominant manner. last updated: 11/17/2014

MalaCards based summary: Hemiplegic Migraine, also known as migraine hemiplegic, is related to familial hemiplegic migraine and sporadic hemiplegic migraine. An important gene associated with Hemiplegic Migraine is CACNA1A (Calcium Voltage-Gated Channel Subunit Alpha1 A), and among its related pathways are Rapid glucocorticoid signaling and Nongenotropic Androgen signaling. Affiliated tissues include brain, testes and trigeminal ganglion, and related mouse phenotypes are Increased viability with SS1P at EC90 and muscle.

Related Diseases for Hemiplegic Migraine

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Diseases in the Hemiplegic Migraine family:

Migraine, Familial Hemiplegic, 2 Migraine, Familial Hemiplegic, 3
Migraine, Familial Hemiplegic, 1 Familial Hemiplegic Migraine
Sporadic Hemiplegic Migraine Familial or Sporadic Hemiplegic Migraine

Diseases related to Hemiplegic Migraine via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 62)
idRelated DiseaseScoreTop Affiliating Genes
1familial hemiplegic migraine12.7
2sporadic hemiplegic migraine12.5
3familial or sporadic hemiplegic migraine12.1
4migraine, familial hemiplegic, 111.9
5migraine, familial hemiplegic, 211.9
6migraine, familial hemiplegic, 311.9
7alternating hemiplegia of childhood11.6
8episodic ataxia11.3
9migraine with or without aura 111.0
10alternating hemiplegia of childhood 211.0
11hemiplegia alterans11.0
12ataxia10.4
13cerebritis10.3
14neuronitis10.3
15epilepsy10.2
16cerebellar ataxia10.2
17hemiplegia10.2
18encephalopathy10.1
19atrial fibrillation and stroke10.1ATP1A2, CACNA1A, PRRT2, SCN1A
20syphilitic spinal sclerosis10.1GNB1, PRRT2, SCN1A
21placental abruption10.1ATP1A2, CACNA1A, PRRT2
22acro-pectoro-renal dysplasia10.1ATP1A2, CACNA1A, PRRT2, SCN1A
23ramsay hunt syndrome i10.1PRRT2, SLC2A1
24infantile hypotonia10.1ATP1A2, CACNA1A, CALCA, SCN1A
25myopathy mitochondrial cataract10.1SCN1A, SLC2A1
26tonoki syndrome10.0ATP1A2, ATP1B1, ATP1B2
27glut1 deficiency syndrome 210.0PRRT2, SLC2A1
28moyamoya disease10.0
29migraine with aura10.0
30cadasil10.0
31weber syndrome10.0
32episodic ataxia, type 29.9
33patent foramen ovale9.9
34retinitis9.9
35dystonia9.9
36retinal degeneration9.9
37meningitis9.9
38salpingo-oophoritis9.9ATP1A2, ATP1A3, CACNA1A, CALCA, SCN1A, SLC2A1
39interstitial emphysema9.8ATP1A2, CACNA1A, KCNK18, NOTCH3, PRRT2
40deafness, autosomal dominant 79.8ATP1A2, ATP1A3, CACNA1A, CALCA, SLC2A1, XK
41cystic fibrosis9.8
42capos syndrome9.8
43crest syndrome9.8
44arteriovenous malformation9.8
45aseptic meningitis9.8
46status epilepticus9.8
47ischemia9.8
48mood disorder9.8
49erdheim-chester disease9.8
50intracranial hypertension9.8

Graphical network of the top 20 diseases related to Hemiplegic Migraine:



Diseases related to hemiplegic migraine

Symptoms & Phenotypes for Hemiplegic Migraine

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GenomeRNAi Phenotypes related to Hemiplegic Migraine according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00376-A-110.5ATP1A3, GNAI2, GNB1

MGI Mouse Phenotypes related to Hemiplegic Migraine according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053699.4ATP1A2, ATP1A3, ATP1B1, CACNA1A, NOTCH3, SCN5A
2MP:00028739.2ATP1A2, ATP1B1, CACNA1A, GNAI2, NOTCH3, OPRM1
3MP:00053888.7ATP1A2, ATP1A3, ATP1B1, CACNA1A, GNAI2, GNB1
4MP:00053867.9ATP1A2, ATP1A3, ATP1B2, CACNA1A, GNAI2, GNB1
5MP:00107687.5ATP1A2, ATP1A3, ATP1B1, ATP1B2, CACNA1A, GNAI2
6MP:00036317.0ATP1A2, ATP1A3, ATP1B2, CACNA1A, GNAI2, GNB1

Drugs & Therapeutics for Hemiplegic Migraine

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Drugs for Hemiplegic Migraine (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
TopiramateapprovedPhase 2, Phase 324997240-79-45284627
Synonyms:
-D-fructopyranose deriv.
.beta.-D-Fructopyranose, 2,3:4,5-bis-O-(1-methylethylidene)-, sulfamate (9CI)
2,3-4,5-bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate
2,3:4,5-Bis-O-(1-methylethylidene) .beta.-D-fructopyranose sulfamate
2,3:4,5-Bis-O-(1-methylethylidene)-36-D-fructo-pyranose sulfamate
2,3:4,5-Bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate
2,3:4,5-Di- O -isopropylidene-(beta)-D-fructopyranose sulfamate
2,3:4,5-Di-O-isopropylidene-beta-D-fructopyranose sulfamate
5H-Bis[1,3]dioxolo[4,5-b:4',5'-d]pyran, .beta.
97240-79-4
AKOS000424547
BIDD:GT0854
BIDD:PXR0127
BRN 5988957
BSPBio_002306
C052342
C07502
C12H21NO8S
CBChromo1_000352
CHEBI:129573
CHEMBL220492
CID5284627
CPD000466325
Cilag brand of topiramate
D00537
DB00273
Epitoma
Epitomax
HMS1922H06
HMS2051L09
HMS2093D20
HSDB 7531
Janssen brand of topiramate
KS-1122
KW-6485
LS-187392
LS-69764
MLS000759431
MLS001424070
McN 4853
McN-4853
MolPort-001-615-062
MolPort-002-885-869
NCGC00178714-01
 
Ortho brand of topiramate
RWJ 17021
RWJ-17021
RWJ-17021-000
S1438_Selleck
SAM001246601
SMR000466325
SPBio_000995
SPECTRUM1505801
STOCK1N-71037
Spectrum2_001128
T0575_SIGMA
TL8006021
TOR
TPM
Tipiramate
Tipiramate [French]
Tipiramato
Tipiramato [Spanish]
Topamac
Topamax
Topamax (TN)
Topamax Sprinkle
Topamax, Topiramate
Topimax
Topina
Topiramate
Topiramate (JAN/USAN/INN)
Topiramate (TPM)
Topiramate / Placebo
Topiramate [USAN:BAN:INN]
Topiramato
Topiramato [INN-Spanish]
Topiramatum
Topiramatum [INN-Latin]
Topiramic acid
Topomax
UNII-0H73WJJ391
USL-255
[(3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl]methyl sulfamate
beta-D-Fructopyranose, 2,3:4,5-bis-O-(1-methylethylidene)-, sulfamate
beta.-D-Fructopyranose, 2,3:4,5-bis-O-(1-methylethylidene)-, 1-sulfamate
topiramate
topiramate tablet
topiramatum [Latin]
2AnticonvulsantsPhase 2, Phase 32695
3Protective AgentsPhase 2, Phase 37443
4Anti-Obesity AgentsPhase 2, Phase 3413
5Neuroprotective AgentsPhase 2, Phase 31716
6
Nitroglycerinapproved, investigational15655-63-04510
Synonyms:
1,2,3-Propanetrioltrinitrate
1,2,3-Propanetriyl nitrate
100292-13-5
105469-31-6
55-63-0
80066-48-4
8013-23-8
9010-02-0
AC1L1IBV
Adesitrin
Aldonitrin
Angibid
Angiolingual
Angiplex
Anglix
Angonist
Angorin
Anogesic
Aquo-Trimitrosan
BIDD:GT0142
BRN 1802063
Blasting gelatin
Blasting oil
Buccal
Buccard
C07455
C3H5N3O9
CCRIS 4089
CHEBI:28787
CHEMBL730
CID4510
CPD-143
Cardabid
Cardamist
Cardinit
Cardiodisco
Cellegesic
Chitamite
Colenitral
Cordipatch
Corditrine
Coro-Nitro
D00515
D005996
DB00727
Dauxona
Deponit
Deponit 5
Deponit TTS 10
Deponit TTS 5
Deponit-5
Diafusor
Discotrine
Dynamite
EINECS 200-240-8
Epinitril
GTN
GTN-Pohl
Gepan Nitroglicerin
Gilucor nitro
Gilustenon
Glonoin
Glycerin trinitrate
Glycerine trinitrate
Glycerintrinitrate
Glycerol trinitrate
Glycerol, nitric acid triester
Glyceroli trinitratis
Glyceroltrinitraat
Glyceroltrinitrat
Glyceryl
Glyceryl nitrate
Glyceryl trinitrate
Glycerylnitrat
Glytrin
HMS2094M15
HSDB 30
Herwicard
Herzer
IMX-150
Klavikordal
LS-7741
Lenitral
Lentonitrina
MED-2002
MQX-503
Mi-Trates
Millisrol
Minitram
Minitran
Minitran (TN)
Minitro
Mionitrat
Myocon
Myoglycerin
Myovin
NG
NITRO IV
NK-843
NTG
Natispray
Neos nitro OPT
Niglin
Niglycon
Niong
Niong Retard
Nirmin
Nit-Ret
Nitora
Nitradisc
Nitradisc Pad
Nitradisc TTS
Nitrangin
Nitrek
Nitriderm
Nitriderm TTS
Nitrine-TDC
Nitro Bid
Nitro Dur
Nitro Dur TTS
Nitro Mack Retard
Nitro Retard
Nitro Rorer
Nitro-Bid
Nitro-Dur 10
Nitro-Dur 5
Nitro-Gesanit Retard
Nitro-M-Bid
Nitro-Mack Retard
Nitro-Par
Nitro-Pflaster
Nitro-Span
Nitro-Time
Nitro-bid (TN)
Nitro-dur
Nitro-dur (TN)
Nitro-lent
NitroBid
NitroCor
 
NitroDur
NitroMist
NitroQuick
NitroQuik
Nitroard
Nitrobaat
Nitrobid Oint
Nitrobukal
Nitrocap
NitrocapT.D
NitrocapT.D.
Nitrocard
Nitrocerin
Nitrocine
Nitrocine 5
Nitroclyn
Nitrocontin
Nitrocontin Continus
Nitrocot
Nitroderm
Nitroderm TTS
Nitroderm TTS Ext
Nitroderm TTS-5
Nitrodisc
Nitrodyl
Nitrodyl TTS
Nitrogard
Nitrogard-SR
Nitroglicerina
Nitrogliceryna
Nitroglin
Nitroglycerin
Nitroglycerin (NG)
Nitroglycerin ointment
Nitroglycerin-ACC
Nitroglycerine
Nitroglycerol
Nitroglyn
Nitroject
Nitrol Ointment
Nitrolan
Nitroletten
Nitrolin
Nitrolingual
Nitrolingual Spray
Nitrolowe
Nitromack Retard
Nitromed
Nitromel
Nitromex
Nitromint
Nitromint Aerosol
Nitromint Retard
Nitromist
Nitromist (TN)
Nitronal Aqueous
Nitronet
Nitrong
Nitrong Retard
Nitrong parenteral
Nitrong-SR
Nitropatch
Nitropen
Nitropercuten
Nitroperlinit
Nitroplast
Nitroprol
Nitropront
Nitroprontan
Nitrorectal
Nitroretard
Nitrorex
Nitrospan
Nitrostabilin
Nitrostat
Nitrovis
Nitrozell retard
Nysconitrine
Percutol
Percutol Oint
Percutol Oint.
Perganit
Perglottal
Perlinganit
Plastranit
Polnitrin
Propane-1,2,3-triyl trinitrate
RCRA waste no. P081
Ratiopharm
Rectogesic
SDM No. 17
SK-106N
SK-866
SK-878
Soup
Spirit of glonoin
Susadrin
Suscard
Sustac
Sustak
Sustonit
TNG
Temponitrin
Top-Nitro
Transderm Nitro
Transderm nitro
Transderm-N TTS
Transderm-Nitro TTS
Transderm-nitro
Transderm-nitro (TN)
Transiderm-nitro
Tridil
Tridil sublin
Trinalgon
Trinipatch
Triniplas
Trinitrate, Glyceryl
Trinitrin
Trinitrin Tablets
Trinitrina Erba
Trinitrine
Trinitroglycerin
Trinitroglycerol
Trinitrol
Trinitrolong
Trinitron
Trinitrosan
Turicard
UN0143
UN0144
UN1204
UN3064
UN3319
UNII-G59M7S0WS3
Vascana
Vasoglyn
Vasolator
Vernies
Willong
c0061
nitroglycerin
7
Salmon Calcitoninapproved, investigational9547931-85-116129616
Synonyms:
135506-95-5
47931-85-1
Astronin
Biocalcin
Bionocalcin
C028815
C06865
C145H239N43O48S2
CALCITONIN, SALMON
Cadens
Calciben
Calcihexal
Calcimar
Calcimar (TN)
Calcimonta
Calcinil
Calcioton
Calcitonin (Salmon Synthetic)
Calcitonin (salmon)
Calcitonin 1 precursor
Calcitonin Salmon
Calcitonin [USAN:INN:BAN:JAN]
Calcitonin salmon
Calcitonin salmon (USAN/INN)
Calcitonin salmon (synthesis)
Calcitonin salmon (synthesis) (JAN)
Calcitonin salmon recombinant
Calcitonin vom lachs
Calcitonin, salmar
Calcitonin, salmon
Calcitonin, salmon, for bioassay
Calcitonin,salmon
Calcitonin-salmon
Calcitonina
Calcitonine de saumon
Calcitoran
Calco
Calogen
Calsynar
Calsynar Lyo L
Caltine
Casalm
Catonin
Cibacalcin
Cibacalcine
Citonina
 
D00249
EINECS 256-342-8
Eptacalcin
Forcaltonin
Fortical
Fortical (TN)
Ipocalcin
Isi-calcin
Kalsimin
Karil
LS-48624
Miacalcic
Miacalcin
Miacalcin (TN)
Miracalcic
Oseototal
Osseocalcina
Osteobion
Osteovis
Ostosalm
Ostostabil
Porostenina
Prontocalcin
Quosten
Riostin
Rulicalcin
Salcat
Salcatonin
Salcatyn
Salmocalcin
Salmofar
Salmon calcitonin
Salmon calcitonin I
Salmon calcitonin-(I-32)
Salmotonin
Sical
Stalcin
Staporos
Steocin
TZ-CT
Thyrocalcitonin (salmon)
Tonocalcin
UNII-7SFC6U2VI5
Ucecal
recombinant salmon calcitonin
salmon calcitonin (1-32)
synthetic salmon calcitonin
8
Pancrelipaseapproved97053608-75-6
Synonyms:
1,4-alpha-D- glucan glucanohydrolase
PA
 
Pancreatic alpha-amylase precursor
Pancrelipase (amylase
lipase
protease)
9Calcitonin Gene-Related Peptide95
10Vasodilator Agents3543
11calcitonin107
12Bone Density Conservation Agents3376
13pancreatin970

Interventional clinical trials:

idNameStatusNCT IDPhase
1Dose Comparison Study of Topiramate in Pediatric Subjects With Basilar/Hemiplegic MigraineCompletedNCT00131443Phase 2, Phase 3
2A Study of Topiramate in Pediatric Subjects With Basilar/Hemiplegic MigraineCompletedNCT00158002Phase 2
3Glyceryl-Trinitrate-Induced Headache in Patients With Familial Hemiplegic MigraineCompletedNCT00541736
4Calcitonin Gene Related Peptide-Induced Headache in Patients With Familial Hemiplegic Migraine Type 1 and 2.CompletedNCT00358839
5Glyceryl-Trinitrate-Induced Headache in Patients With Familial Hemiplegic Migraine Type 1 and 2CompletedNCT00257985
6Calcitonin Gene-related Peptide in Familial Hemiplegic Migraine (FHM) and Migraine With Aura (MA)CompletedNCT00687947
7Genetic Analysis of Children With Cyclic Vomiting Syndrome (CVS) and MigrainesRecruitingNCT00727974

Search NIH Clinical Center for Hemiplegic Migraine

Genetic Tests for Hemiplegic Migraine

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Anatomical Context for Hemiplegic Migraine

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MalaCards organs/tissues related to Hemiplegic Migraine:

36
Brain, Testes, Trigeminal ganglion, Tongue, Thalamus, Kidney, Cortex

Publications for Hemiplegic Migraine

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Articles related to Hemiplegic Migraine:

(show top 50)    (show all 396)
idTitleAuthorsYear
1
Epilepsy in hemiplegic migraine: Genetic mutations and clinical implications. (28058944)
2017
2
Inefficient constitutive inhibition of P2X3 receptors by brain natriuretic peptide system contributes to sensitization of trigeminal sensory neurons in a genetic mouse model of familial hemiplegic migraine. (27175010)
2016
3
Defective glutamate and K+ clearance by cortical astrocytes in familial hemiplegic migraine type 2. (27354390)
2016
4
Early-onset familial hemiplegic migraine due to a novel SCN1A mutation. (26763045)
2016
5
Clinical and electroencephalographic abnormalities during the full duration of a sporadic hemiplegic migraine attack. (27155821)
2016
6
Postoperative Hemiplegic Migraine After a Laparoscopic Cholecystectomy: A Case Report. (28045726)
2016
7
A retrospective analysis of triptan and dhe use for basilar and hemiplegic migraine. (27062528)
2016
8
Time course of downbeat positioning nystagmus in familial hemiplegic migraine type 1 treated with acetazolamide. (27538634)
2016
9
Prevalence of lifetime depression in a large hemiplegic migraine cohort. (27807184)
2016
10
Recurrent coma and fever in familial hemiplegic migraine type 2. A prospective 15-year follow-up of a large family with a novel ATP1A2 mutation. (27226003)
2016
11
A novel SCN1A mutation identified in a Chinese family with familial hemiplegic migraine: A case report. (27919014)
2016
12
Glutamate-system defects behind psychiatric manifestations in a familial hemiplegic migraine type 2 disease-mutation mouse model. (26911348)
2016
13
Activity-dependent calcium, oxygen, and vascular responses in a mouse model of familial hemiplegic migraine type 1. (27314908)
2016
14
Hemiplegic Migraine Presenting with Prolonged Somnolence: A Case Report. (27790126)
2016
15
Hemiplegic migraine and late-onset photosensitive epileptic seizures. (27406575)
2016
16
Familial Hemiplegic Migraine with Severe Attacks: A New Report with ATP1A2 Mutation. (27818813)
2016
17
Loss of inhibition by brain natriuretic peptide over P2X3 receptors contributes to enhanced spike firing of trigeminal ganglion neurons in a mouse model of familial hemiplegic migraine type-1. (27346147)
2016
18
Familial hemiplegic migraine type-1 mutated cav2.1 calcium channels alter inhibitory and excitatory synaptic transmission in the lateral superior olive of mice. (25481823)
2015
19
Abnormal cortical synaptic transmission in CaV2.1 knockin mice with the S218L missense mutation which causes a severe familial hemiplegic migraine syndrome in humans. (25741235)
2015
20
CAPOS syndrome and hemiplegic migraine in a novel pedigree with the specific ATP1A3 mutation. (26453127)
2015
21
Concordant Occipital and Supraorbital Neurostimulation Therapy for Hemiplegic Migraine; Initial Experience; A Case Series. (25688595)
2015
22
A case report of sporadic hemiplegic migraine associated cerebral hypoperfusion: comparison of arterial spin labeling and dynamic susceptibility contrast perfusion MR imaging. (26250760)
2015
23
Biphasic neurovascular changes in prolonged migraine aura in familial hemiplegic migraine type 2. (25411546)
2015
24
Novel frameshift mutation in the CACNA1A gene causing a mixed phenotype of episodic ataxia and familiar hemiplegic migraine. (25468264)
2015
25
Perfusion and pH MRI in familial hemiplegic migraine with prolonged aura. (25948653)
2015
26
Stress hormone corticosterone enhances susceptibility to cortical spreading depression in familial hemiplegic migraine type 1 mutant mice. (25447936)
2015
27
Plasma metabolic profiling after cortical spreading depression in a transgenic mouse model of hemiplegic migraine by capillary electrophoresis - mass spectrometry. (25856790)
2015
28
Familial Hemiplegic Migraine and Recurrent Episodes of Psychosis: A Case Report. (26087244)
2015
29
Abnormal synaptic Ca(2+) homeostasis and morphology in cortical neurons of familial hemiplegic migraine type 1 mutant mice. (26032020)
2015
30
Familial hemiplegic migraine type 1 associated with parkinsonism: a case report. (25969684)
2015
31
Sporadic hemiplegic migraine and giant tumefactive perivascular space: Is there an association? (26696413)
2015
32
An altered GABA-A receptor function in spinocerebellar ataxia type 6 and familial hemiplegic migraine type 1 associated with the CACNA1A gene mutation. (26675662)
2014
33
Familial hemiplegic migraine treated by sodium valproate and lamotrigine. (24443394)
2014
34
A novel ATP1A2 gene mutation in familial hemiplegic migraine and epilepsy. (23918834)
2014
35
Two novel SCN1A mutations identified in families with familial hemiplegic migraine. (24707016)
2014
36
Pharmacological Correction of Gating Defects in the Voltage-Gated Cav2.1 Ca(2+) Channel due to a Familial Hemiplegic Migraine Mutation. (24411734)
2014
37
A novel SLC2A1 mutation linking hemiplegic migraine with alternating hemiplegia of childhood. (24824604)
2014
38
Repeated encephalopathy and hemicerebral atrophy in a patient with familial hemiplegic migraine type 1. (25274239)
2014
39
A hyperexcitability phenotype in mouse trigeminal sensory neurons expressing the R192Q Cacna1a missense mutation of familial hemiplegic migraine type-1. (24583041)
2014
40
Hemiplegic migraine: neuroimaging findings during a hemiplegic migraine attack. (24512003)
2014
41
Familial hemiplegic migraine due to L263V SCN1A mutation: Discordance for epilepsy between two kindreds from Douro Valley. (24646837)
2014
42
Sturge-Weber syndrome with late onset hemiplegic migraine-like attacks and progressive unilateral cerebral atrophy. (24045571)
2014
43
Functional analysis of human Na(+)/K(+)-ATPase familial or sporadic hemiplegic migraine mutations expressed in Xenopus oocytes. (24921013)
2014
44
Synaptic gain-of-function effects of mutant Cav2.1 channels in a mouse model of familial hemiplegic migraine are due to increased basal [Ca2+]i. (24849341)
2014
45
Familial hemiplegic migraine: A model for the genetic studies of migraine. (24707017)
2014
46
PRRT2 and hemiplegic migraine: a complex association. (24928127)
2014
47
Arterial surgery for sporadic hemiplegic migraine: preliminary results. (24703384)
2014
48
The prevalence of familial hemiplegic migraine with cerebellar ataxia and spinocerebellar ataxia type 6 in Portugal. (24898624)
2014
49
Hemiplegic migraine: An atypical presentation of Moyamoya disease. (25538508)
2014
50
Biochemical changes in the brain of hemiplegic migraine patients measured with 7 tesla 1H-MRS. (24651393)
2014

Variations for Hemiplegic Migraine

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Expression for genes affiliated with Hemiplegic Migraine

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Search GEO for disease gene expression data for Hemiplegic Migraine.

Pathways for genes affiliated with Hemiplegic Migraine

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Pathways related to Hemiplegic Migraine according to GeneCards Suite gene sharing:

(show all 36)
idSuper pathwaysScoreTop Affiliating Genes
19.4GNB1, GNG2
29.4GNB1, GNG2
39.3CALCA, NOTCH3, OPRM1, SCN1A, SCN5A
49.1ATP1A2, ATP1A3, ATP1B1, ATP1B2
59.1ATP1A2, ATP1A3, ATP1B1, ATP1B2
6
Show member pathways
9.1ATP1A2, ATP1A3, ATP1B1, ATP1B2
79.1ATP1A2, ATP1A3, ATP1B1, ATP1B2
89.1ATP1A2, ATP1A3, ATP1B1, ATP1B2
99.1ATP1A2, ATP1A3, ATP1B1, ATP1B2
109.1ATP1A2, ATP1A3, ATP1B1, ATP1B2
119.1ATP1A2, ATP1A3, ATP1B1, ATP1B2
12
Show member pathways
9.1ATP1A2, ATP1A3, ATP1B1, ATP1B2
139.0GNAI2, GNB1, GNG2
149.0GNAI2, GNB1, GNG2
15
Show member pathways
9.0GNAI2, GNB1, GNG2
169.0GNAI2, GNB1, GNG2
179.0GNAI2, GNB1, GNG2
188.9CACNA1A, GNAI2, GNB1, GNG2
198.9CACNA1A, GNAI2, GNB1, GNG2
208.8CALCA, GNAI2, GNB1, GNG2
21
Show member pathways
8.8ATP1A2, ATP1A3, ATP1B1, ATP1B2, GNAI2
22
Show member pathways
8.8ATP1A2, ATP1A3, ATP1B1, ATP1B2, GNAI2
238.8GNAI2, GNB1, GNG2, NOTCH3
248.8ATP1A2, ATP1A3, ATP1B1, ATP1B2, SLC2A1
25
Show member pathways
8.8ATP1A2, ATP1A3, ATP1B1, ATP1B2, SLC2A1
26
Show member pathways
8.7ATP1A2, ATP1A3, ATP1B1, ATP1B2, SCN1A, SCN5A
27
Show member pathways
8.7GNAI2, GNB1, GNG2, SLC2A1
28
Show member pathways
8.7CACNA1A, GNAI2, GNB1, GNG2, SCN1A
29
Show member pathways
8.6CACNA1A, GNAI2, GNB1, GNG2, OPRM1
30
Show member pathways
8.6ATP1A2, ATP1A3, ATP1B1, ATP1B2, GNAI2, SCN5A
318.5ATP1A2, ATP1A3, ATP1B1, ATP1B2, NOTCH3, SLC2A1
32
Show member pathways
8.5CACNA1A, GNAI2, GNB1, GNG2, SLC2A1
33
Show member pathways
8.4CACNA1A, GNAI2, GNB1, GNG2, SCN1A, SCN5A
34
Show member pathways
8.3ATP1A2, ATP1A3, ATP1B1, ATP1B2, KCNK18, SCN1A
35
Show member pathways
7.7ATP1B1, ATP1B2, CACNA1A, CALCA, GNAI2, GNB1
36
Show member pathways
7.7ATP1A2, ATP1A3, ATP1B1, ATP1B2, GNB1, GNG2

GO Terms for genes affiliated with Hemiplegic Migraine

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Cellular components related to Hemiplegic Migraine according to GeneCards Suite gene sharing:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1axonGO:003042410.4ATP1A3, CALCA, OPRM1, SCN1A
2intercalated discGO:001470410.4ATP1A2, ATP1B1, SCN1A, SCN5A
3myelin sheathGO:004320910.3ATP1A2, ATP1A3, ATP1B1, GNB1
4caveolaGO:000590110.2ATP1A2, ATP1B1, SCN5A, SLC2A1
5T-tubuleGO:003031510.1ATP1A2, SCN1A, SCN5A
6voltage-gated sodium channel complexGO:000151810.0SCN1A, SCN5A
7extracellular vesicleGO:190356110.0ATP1A2, ATP1A3, ATP1B1, GNAI2, GNB1
8heterotrimeric G-protein complexGO:00058349.9GNAI2, GNB1, GNG2
9sarcolemmaGO:00423839.7ATP1A2, ATP1A3, ATP1B1, OPRM1, SCN5A
10sodium:potassium-exchanging ATPase complexGO:00058909.6ATP1A2, ATP1A3, ATP1B1, ATP1B2
11integral component of membraneGO:00160217.4ATP1A2, ATP1A3, ATP1B1, ATP1B2, CACNA1A, KCNK18
12membraneGO:00160205.9ATP1A2, ATP1A3, ATP1B1, ATP1B2, CACNA1A, GNAI2
13plasma membraneGO:00058865.7ATP1A2, ATP1A3, ATP1B1, ATP1B2, CACNA1A, GNAI2

Biological processes related to Hemiplegic Migraine according to GeneCards Suite gene sharing:

(show all 34)
idNameGO IDScoreTop Affiliating Genes
1cellular response to steroid hormone stimulusGO:007138310.8ATP1A2, ATP1A3
2neuromuscular process controlling postureGO:005088410.8PRRT2, SCN1A
3cardiac muscle cell action potential involved in contractionGO:008600210.8SCN1A, SCN5A
4response to glycosideGO:190341610.8ATP1A2, ATP1A3
5membrane depolarization during cardiac muscle cell action potentialGO:008601210.8ATP1A2, SCN5A
6regulation of cardiac muscle cell contractionGO:008600410.8ATP1A2, SCN5A
7potassium ion import across plasma membraneGO:199057310.7ATP1A2, ATP1B1
8relaxation of cardiac muscleGO:005511910.7ATP1A2, ATP1B1
9G-protein coupled acetylcholine receptor signaling pathwayGO:000721310.6GNAI2, GNB1
10membrane depolarization during action potentialGO:008601010.6CACNA1A, SCN1A, SCN5A
11positive regulation of potassium ion importGO:190328810.3ATP1B1, ATP1B2
12positive regulation of potassium ion transmembrane transporter activityGO:190101810.3ATP1B1, ATP1B2
13positive regulation of sodium ion export from cellGO:190327810.3ATP1B1, ATP1B2
14cardiac muscle contractionGO:006004810.3ATP1A2, ATP1A3, ATP1B1, SCN5A
15cellular calcium ion homeostasisGO:000687410.3ATP1B1, CALCA, XK
16regulation of ion transmembrane transportGO:003476510.2CACNA1A, KCNK18, SCN1A, SCN5A
17cellular response to catecholamine stimulusGO:007187010.1GNB1, GNG2
18cellular response to prostaglandin E stimulusGO:007138010.1GNB1, GNG2
19membrane repolarizationGO:008600910.1ATP1A2, ATP1B1, ATP1B2
20ATP hydrolysis coupled transmembrane transportGO:00906629.9ATP1A2, ATP1A3, ATP1B1, ATP1B2
21cell communication by electrical coupling involved in cardiac conductionGO:00860649.9ATP1A2, ATP1A3, ATP1B1, ATP1B2
22cellular potassium ion homeostasisGO:00300079.9ATP1A2, ATP1A3, ATP1B1, ATP1B2
23cellular sodium ion homeostasisGO:00068839.9ATP1A2, ATP1A3, ATP1B1, ATP1B2
24establishment or maintenance of transmembrane electrochemical gradientGO:00102489.9ATP1A2, ATP1A3, ATP1B1, ATP1B2
25potassium ion importGO:00101079.9ATP1A2, ATP1A3, ATP1B1, ATP1B2
26regulation of cardiac conductionGO:19037799.9ATP1A2, ATP1A3, ATP1B1, ATP1B2
27adenylate cyclase-activating dopamine receptor signaling pathwayGO:00071919.9GNB1, GNG2, OPRM1
28sodium ion export from cellGO:00363769.9ATP1A2, ATP1A3, ATP1B1, ATP1B2
29potassium ion transportGO:00068139.5ATP1A2, ATP1A3, ATP1B1, ATP1B2, KCNK18
30ion transmembrane transportGO:00342209.5ATP1A2, ATP1A3, ATP1B1, ATP1B2, SCN1A, SCN5A
31protein foldingGO:00064579.5GNAI2, GNB1, GNG2, PRKCSH
32sodium ion transportGO:00068149.4ATP1A2, ATP1A3, ATP1B1, ATP1B2, SCN1A, SCN5A
33ion transportGO:00068118.9ATP1A2, ATP1A3, ATP1B1, ATP1B2, CACNA1A, KCNK18
34transportGO:00068107.3ATP1A2, ATP1A3, ATP1B1, ATP1B2, CACNA1A, KCNK18

Molecular functions related to Hemiplegic Migraine according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1potassium ion bindingGO:003095510.4ATP1A2, ATP1B1
2sodium ion bindingGO:003140210.3ATP1A2, ATP1B1
3ion channel activityGO:000521610.3CACNA1A, SCN1A, SCN5A
4steroid hormone bindingGO:199023910.1ATP1A2, ATP1A3
5G-protein beta-subunit bindingGO:003168110.0GNG2, OPRM1
6sodium:potassium-exchanging ATPase activityGO:00053919.3ATP1A2, ATP1A3, ATP1B1, ATP1B2

Sources for Hemiplegic Migraine

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet