MCID: HMP006
MIFTS: 39

Hemiplegic Migraine malady

Genetic diseases, Rare diseases, Neuronal diseases categories

Aliases & Classifications for Hemiplegic Migraine

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Sources:
45NIH Rare Diseases, 65UMLS, 47Novoseek
See all sources

Aliases & Descriptions for Hemiplegic Migraine:

Name: Hemiplegic Migraine 45 65
 
Migraine Hemiplegic 47


Classifications:



Summaries for Hemiplegic Migraine

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NIH Rare Diseases:45 Hemiplegic migraine (hm) is a rare type of migraine with aura that occurs with motor weakness during the aura. there are two types of hm which are distinguished based on the family history: familial hemiplegic migraine (fhm, in which at least one other family member has the condition) and sporadic hemiplegic migraine (shm, in which there is no family history). signs and symptoms vary but may include visual disturbances, sensory loss, difficulty with speech, weakness on one side of the body, confusion, and impaired consciousness. severe attacks may occur in both types with prolonged hemiplegia, coma, fever and/or seizures. fhm may be caused by a mutation in any of several genes and is inherited in an autosomal dominant manner. last updated: 11/17/2014

MalaCards based summary: Hemiplegic Migraine, also known as migraine hemiplegic, is related to migraine, familial hemiplegic, 3 and alternating hemiplegia of childhood. An important gene associated with Hemiplegic Migraine is CACNA1A (Calcium Channel, Voltage-Dependent, P/Q Type, Alpha 1A Subunit), and among its related pathways are Ion transport by P-type ATPases and Endocrine and other factor-regulated calcium reabsorption. Affiliated tissues include brain, testes and trigeminal ganglion, and related mouse phenotypes are normal and homeostasis/metabolism.

Related Diseases for Hemiplegic Migraine

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Diseases in the Hemiplegic Migraine family:

Migraine, Familial Hemiplegic, 2 Migraine, Familial Hemiplegic, 3
Migraine, Familial Hemiplegic, 1 Familial Hemiplegic Migraine
Sporadic Hemiplegic Migraine Familial or Sporadic Hemiplegic Migraine

Diseases related to Hemiplegic Migraine via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 75)
idRelated DiseaseScoreTop Affiliating Genes
1migraine, familial hemiplegic, 331.4MGR6, SCN1A
2alternating hemiplegia of childhood30.8ATP1A2, ATP1A3, CACNA1A, CALCA, SLC2A1
3migraine with or without aura 130.7ATP1A2, CACNA1A, CALCA, NOTCH3, PRRT2, SCN1A
4familial hemiplegic migraine11.3
5sporadic hemiplegic migraine11.0
6ataxia10.8
7migraine, familial hemiplegic, 110.8
8migraine, familial hemiplegic, 210.7
9cerebritis10.7
10neuronitis10.7
11familial or sporadic hemiplegic migraine10.6
12migraine with aura10.6
13episodic ataxia10.6
14cerebellar ataxia10.6
15hemiplegia10.6
16headache10.6
17encephalopathy10.5
18hansen's disease10.4
19moyamoya disease10.4
20cadasil10.4
21basilar migraine10.4
22weber syndrome10.4
23migraine with or without aura 310.3
24episodic ataxia, type 210.3
25patent foramen ovale10.3
26cerebral arterial disease10.3
27dystonia10.3
28meningitis10.3
29retinal degeneration10.3
30retinitis10.3
31spinocerebellar ataxia10.3
32neurologic diseases10.3
33bassoe syndrome10.3ATP1A2, CACNA1A
34epilepsy, generalized, with febrile seizures plus, type 210.3MGR6, SCN1A
35stargardt macular degeneration10.2ATP1A2, CACNA1A, SCN1A
36esophagus squamous cell papilloma10.2ATP1A2, CACNA1A, PRRT2
37myoclonus cerebellar ataxia deafness10.2SCN1A, SLC2A1
38cystic fibrosis10.1
39alternating hemiplegia of childhood 210.1
40capos syndrome10.1
41progressive hemifacial atrophy10.1
42aseptic meningitis10.1
43status epilepticus10.1
44arteriovenous malformation10.1
45erdheim-chester disease10.1
46crest syndrome10.1
47intracranial hypertension10.1
48ischemia10.1
49mood disorder10.1
50hemicrania continua10.1

Graphical network of the top 20 diseases related to Hemiplegic Migraine:



Diseases related to hemiplegic migraine

Symptoms for Hemiplegic Migraine

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Drugs & Therapeutics for Hemiplegic Migraine

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Drugs for Hemiplegic Migraine (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
TopiramateapprovedPhase 2, Phase 323097240-79-45284627
Synonyms:
-D-fructopyranose deriv.
.beta.-D-Fructopyranose, 2,3:4,5-bis-O-(1-methylethylidene)-, sulfamate (9CI)
2,3-4,5-bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate
2,3:4,5-Bis-O-(1-methylethylidene) .beta.-D-fructopyranose sulfamate
2,3:4,5-Bis-O-(1-methylethylidene)-36-D-fructo-pyranose sulfamate
2,3:4,5-Bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate
2,3:4,5-Di- O -isopropylidene-(beta)-D-fructopyranose sulfamate
2,3:4,5-Di-O-isopropylidene-beta-D-fructopyranose sulfamate
5H-Bis[1,3]dioxolo[4,5-b:4',5'-d]pyran, .beta.
97240-79-4
AKOS000424547
BIDD:GT0854
BIDD:PXR0127
BRN 5988957
BSPBio_002306
C052342
C07502
C12H21NO8S
CBChromo1_000352
CHEBI:129573
CHEMBL220492
CID5284627
CPD000466325
Cilag brand of topiramate
D00537
DB00273
Epitoma
Epitomax
HMS1922H06
HMS2051L09
HMS2093D20
HSDB 7531
Janssen brand of topiramate
KS-1122
KW-6485
LS-187392
LS-69764
MLS000759431
MLS001424070
McN 4853
McN-4853
MolPort-001-615-062
MolPort-002-885-869
NCGC00178714-01
Ortho brand of topiramate
 
Qudexy XR
RWJ 17021
RWJ-17021
RWJ-17021-000
S1438_Selleck
SAM001246601
SMR000466325
SPBio_000995
SPECTRUM1505801
STOCK1N-71037
Spectrum2_001128
T0575_SIGMA
TL8006021
TOR
TPM
Tipiramate
Tipiramate [French]
Tipiramato
Tipiramato [Spanish]
Topamac
Topamax
Topamax (TN)
Topamax Sprinkle
Topamax, Topiramate
Topimax
Topina
Topiramate
Topiramate (JAN/USAN/INN)
Topiramate (TPM)
Topiramate / Placebo
Topiramate [USAN:BAN:INN]
Topiramato
Topiramato [INN-Spanish]
Topiramatum
Topiramatum [INN-Latin]
Topiramic acid
Topomax
Trokendi Xr
UNII-0H73WJJ391
USL-255
[(3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl]methyl sulfamate
beta-D-Fructopyranose, 2,3:4,5-bis-O-(1-methylethylidene)-, sulfamate
beta.-D-Fructopyranose, 2,3:4,5-bis-O-(1-methylethylidene)-, 1-sulfamate
topiramate
topiramate tablet
topiramatum [Latin]
2
Nitroglycerinapproved, investigational13355-63-04510
Synonyms:
1,2,3-Propanetrioltrinitrate
1,2,3-Propanetriyl nitrate
100292-13-5
105469-31-6
55-63-0
80066-48-4
8013-23-8
9010-02-0
AC1L1IBV
Adesitrin
Aldonitrin
Angibid
Angiolingual
Angiplex
Anglix
Angonist
Angorin
Anogesic
Aquo-Trimitrosan
BIDD:GT0142
BRN 1802063
Blasting gelatin
Blasting oil
Buccal
Buccard
C07455
C3H5N3O9
CCRIS 4089
CHEBI:28787
CHEMBL730
CID4510
CPD-143
Cardabid
Cardamist
Cardinit
Cardiodisco
Cellegesic
Chitamite
Colenitral
Cordipatch
Corditrine
Coro-Nitro
D00515
D005996
DB00727
Dauxona
Deponit
Deponit 5
Deponit TTS 10
Deponit TTS 5
Deponit-5
Diafusor
Discotrine
Dynamite
EINECS 200-240-8
Epinitril
GTN
GTN-Pohl
Gepan Nitroglicerin
Gilucor nitro
Gilustenon
Glonoin
Glycerin trinitrate
Glycerine trinitrate
Glycerintrinitrate
Glycerol trinitrate
Glycerol, nitric acid triester
Glyceroli trinitratis
Glyceroltrinitraat
Glyceroltrinitrat
Glyceryl
Glyceryl nitrate
Glyceryl trinitrate
Glycerylnitrat
Glytrin
HMS2094M15
HSDB 30
Herwicard
Herzer
IMX-150
Klavikordal
LS-7741
Lenitral
Lentonitrina
MED-2002
MQX-503
Mi-Trates
Millisrol
Minitram
Minitran
Minitran (TN)
Minitro
Mionitrat
Myocon
Myoglycerin
Myovin
NG
NITRO IV
NK-843
NTG
Natispray
Neos nitro OPT
Niglin
Niglycon
Niong
Niong Retard
Nirmin
Nit-Ret
Nitora
Nitradisc
Nitradisc Pad
Nitradisc TTS
Nitrangin
Nitrek
Nitriderm
Nitriderm TTS
Nitrine-TDC
Nitro Bid
Nitro Dur
Nitro Dur TTS
Nitro Mack Retard
Nitro Retard
Nitro Rorer
Nitro-Bid
Nitro-Dur 10
Nitro-Dur 5
Nitro-Gesanit Retard
Nitro-M-Bid
Nitro-Mack Retard
Nitro-Par
Nitro-Pflaster
Nitro-Span
Nitro-Time
Nitro-bid
Nitro-bid (TN)
Nitro-dur
Nitro-dur (TN)
Nitro-lent
NitroBid
NitroCor
NitroDur
NitroMist
NitroQuick
 
NitroQuik
Nitroard
Nitrobaat
Nitrobid Oint
Nitrobukal
Nitrocap
NitrocapT.D
NitrocapT.D.
Nitrocard
Nitrocerin
Nitrocine
Nitrocine 5
Nitroclyn
Nitrocontin
Nitrocontin Continus
Nitrocot
Nitroderm
Nitroderm TTS
Nitroderm TTS Ext
Nitroderm TTS-5
Nitrodisc
Nitrodyl
Nitrodyl TTS
Nitrogard
Nitrogard-SR
Nitroglicerina
Nitrogliceryna
Nitroglin
Nitroglycerin
Nitroglycerin (NG)
Nitroglycerin ER
Nitroglycerin Lingual
Nitroglycerin Transdermal Delivery System
Nitroglycerin Transdermal System
Nitroglycerin ointment
Nitroglycerin-ACC
Nitroglycerine
Nitroglycerol
Nitroglyn
Nitroject
Nitrol Ointment
Nitrolan
Nitroletten
Nitrolin
Nitrolingual
Nitrolingual Pumpspray
Nitrolingual Spray
Nitrolowe
Nitromack Retard
Nitromed
Nitromel
Nitromex
Nitromint
Nitromint Aerosol
Nitromint Retard
Nitromist
Nitromist (TN)
Nitronal Aqueous
Nitronet
Nitrong
Nitrong Retard
Nitrong parenteral
Nitrong-SR
Nitropatch
Nitropen
Nitropercuten
Nitroperlinit
Nitroplast
Nitroprol
Nitropront
Nitroprontan
Nitrorectal
Nitroretard
Nitrorex
Nitrospan
Nitrostabilin
Nitrostat
Nitrovis
Nitrozell retard
Nysconitrine
Percutol
Percutol Oint
Percutol Oint.
Perganit
Perglottal
Perlinganit
Plastranit
Polnitrin
Propane-1,2,3-triyl trinitrate
RCRA waste no. P081
Ratiopharm
Rectiv
Rectogesic
SDM No. 17
SK-106N
SK-866
SK-878
Soup
Spirit of glonoin
Susadrin
Suscard
Sustac
Sustak
Sustonit
TNG
Temponitrin
Top-Nitro
Transderm Nitro
Transderm nitro
Transderm-N TTS
Transderm-Nitro TTS
Transderm-nitro
Transderm-nitro (TN)
Transiderm-nitro
Tridil
Tridil sublin
Trinalgon
Trinipatch
Triniplas
Trinitrate, Glyceryl
Trinitrin
Trinitrin Tablets
Trinitrina Erba
Trinitrine
Trinitroglycerin
Trinitroglycerol
Trinitrol
Trinitrolong
Trinitron
Trinitrosan
Turicard
UN0143
UN0144
UN1204
UN3064
UN3319
UNII-G59M7S0WS3
Vascana
Vasoglyn
Vasolator
Vernies
Willong
c0061
nitroglycerin
3
Salmon Calcitoninapproved, investigational4847931-85-116129616
Synonyms:
135506-95-5
47931-85-1
Astronin
Biocalcin
Bionocalcin
C028815
C06865
C145H239N43O48S2
CALCITONIN, SALMON
Cadens
Calciben
Calcihexal
Calcimar
Calcimar (TN)
Calcimonta
Calcinil
Calcioton
Calcitonin (Salmon Synthetic)
Calcitonin (salmon)
Calcitonin 1 precursor
Calcitonin Salmon
Calcitonin [USAN:INN:BAN:JAN]
Calcitonin salmon
Calcitonin salmon (USAN/INN)
Calcitonin salmon (synthesis)
Calcitonin salmon (synthesis) (JAN)
Calcitonin vom lachs
Calcitonin, salmar
Calcitonin, salmon
Calcitonin, salmon, for bioassay
Calcitonin,salmon
Calcitonin-salmon
Calcitonina
Calcitonine de saumon
Calcitoran
Calco
Calogen
Calsynar
Calsynar Lyo L
Caltine
Casalm
Catonin
Cibacalcin
Cibacalcine
Citonina
 
D00249
EINECS 256-342-8
Eptacalcin
Forcaltonin
Fortical
Fortical (TN)
Ipocalcin
Isi-calcin
Kalsimin
Karil
LS-48624
Miacalcic
Miacalcin
Miacalcin (TN)
Miracalcic
Oseototal
Osseocalcina
Osteobion
Osteovis
Ostosalm
Ostostabil
Porostenina
Prontocalcin
Quosten
Riostin
Rulicalcin
Salcat
Salcatonin
Salcatyn
Salmocalcin
Salmofar
Salmon calcitonin
Salmon calcitonin I
Salmon calcitonin-(I-32)
Salmotonin
Sical
Stalcin
Staporos
Steocin
TZ-CT
Thyrocalcitonin (salmon)
Tonocalcin
UNII-7SFC6U2VI5
Ucecal
recombinant salmon calcitonin
salmon calcitonin (1-32)
synthetic salmon calcitonin
4
Pancrelipaseapproved83953608-75-6
Synonyms:
1,4-alpha-D- glucan glucanohydrolase
Creon
PA
Pancreatic alpha-amylase precursor
Pancreaze
 
Pancrelipase
Pertzye
Polocaine-mpf
Ultresa
Viokace
Zenpep
5Calcitonin Gene-Related Peptide48
6calcitonin48
7pancreatin839

Interventional clinical trials:

idNameStatusNCT IDPhase
1Dose Comparison Study of Topiramate in Pediatric Subjects With Basilar/Hemiplegic MigraineCompletedNCT00131443Phase 2, Phase 3
2A Study of Topiramate in Pediatric Subjects With Basilar/Hemiplegic MigraineCompletedNCT00158002Phase 2
3Glyceryl-Trinitrate-Induced Headache in Patients With Familial Hemiplegic MigraineCompletedNCT00541736
4Calcitonin Gene Related Peptide-Induced Headache in Patients With Familial Hemiplegic Migraine Type 1 and 2.CompletedNCT00358839
5Glyceryl-Trinitrate-Induced Headache in Patients With Familial Hemiplegic Migraine Type 1 and 2CompletedNCT00257985
6Calcitonin Gene-related Peptide in Familial Hemiplegic Migraine (FHM) and Migraine With Aura (MA)CompletedNCT00687947
7Genetic Analysis of Children With Cyclic Vomiting Syndrome (CVS) and MigrainesRecruitingNCT00727974

Search NIH Clinical Center for Hemiplegic Migraine

Genetic Tests for Hemiplegic Migraine

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Anatomical Context for Hemiplegic Migraine

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MalaCards organs/tissues related to Hemiplegic Migraine:

33
Brain, Testes, Trigeminal ganglion, Tongue, Thalamus, Kidney, Cortex

Animal Models for Hemiplegic Migraine or affiliated genes

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MGI Mouse Phenotypes related to Hemiplegic Migraine:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.7ATP1A2, ATP1B1, CACNA1A, CALCA, NOTCH3, OPRM1
2MP:00053767.6ATP1A2, ATP1A3, ATP1B1, CACNA1A, CALCA, GNAI2
3MP:00053847.6ATP1B2, CACNA1A, GNAI2, GNB1, NOTCH3, OPRM1
4MP:00053866.5ATP1A2, ATP1A3, ATP1B2, CACNA1A, CALCA, GNAI2
5MP:00036316.3ATP1A2, ATP1A3, ATP1B2, CACNA1A, CALCA, GNAI2
6MP:00107686.2ATP1A2, ATP1A3, ATP1B1, ATP1B2, CACNA1A, CALCA

Publications for Hemiplegic Migraine

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Articles related to Hemiplegic Migraine:

(show top 50)    (show all 374)
idTitleAuthorsYear
1
Abnormal synaptic Ca(2+) homeostasis and morphology in cortical neurons of familial hemiplegic migraine type 1 mutant mice. (26032020)
2015
2
Familial hemiplegic migraine type-1 mutated cav2.1 calcium channels alter inhibitory and excitatory synaptic transmission in the lateral superior olive of mice. (25481823)
2015
3
PRRT2 and hemiplegic migraine: a complex association. (24928127)
2014
4
Hemiplegic migraine: neuroimaging findings during a hemiplegic migraine attack. (24512003)
2014
5
A novel ATP1A2 gene mutation in familial hemiplegic migraine and epilepsy. (23918834)
2014
6
Hemiplegic migraine: An atypical presentation of Moyamoya disease. (25538508)
2014
7
Familial hemiplegic migraine and spreading depression. (25143767)
2014
8
Delayed recovery post anesthesia: an atypical presentation of familial hemiplegic migraine. (24347352)
2013
9
Magnetic Resonance Angiography Evidence of Vasospasm in Children With Suspected Acute Hemiplegic Migraine. (23594822)
2013
10
Hemiplegic migraine with reversible cerebral vasoconstriction caused by ATP1A2 mutations. (23821026)
2013
11
Functional characterization of a novel C-terminal ATP1A2 mutation causing hemiplegic migraine and epilepsy. (23838748)
2013
12
Pulmonary arterial hypertension in familial hemiplegic migraine with ATP1A2 channelopathy. (24136331)
2013
13
Familial hemiplegic migraine with prolonged global aura: follow-up findings of subtraction ictal SPECT co-registered to MRI (SISCOM). (22933508)
2012
14
Stroke and familial hemiplegic migraine. (22608661)
2012
15
Calcitonin gene-related peptide does not cause migraine attacks in patients with familial hemiplegic migraine. (21457239)
2011
16
Increased susceptibility to cortical spreading depression in the mouse model of familial hemiplegic migraine type 2. (21731499)
2011
17
Transient nonverbal learning disorder in a child suffering from Familial Hemiplegic Migraine. (21908445)
2011
18
A novel mutation in CACNA1A associated with hemiplegic migraine, cerebellar dysfunction and late-onset cognitive decline. (21035146)
2011
19
Acute striatal necrosis in hemiplegic migraine with de novo CACNA1A mutation. (22082423)
2011
20
De novo mutations in ATP1A2 and CACNA1A are frequent in early-onset sporadic hemiplegic migraine. (20837964)
2010
21
Insights into migraine mechanisms and CaV2.1 calcium channel function from mouse models of familial hemiplegic migraine. (20194127)
2010
22
Moyamoya disease presented as a case of hemiplegic migraine. (22798438)
2010
23
Neurological picture. Cortical oedema: a link between delusional misidentification syndromes and hemiplegic migraine. (20019221)
2010
24
Large scale calcium channel gene rearrangements in episodic ataxia and hemiplegic migraine: implications for diagnostic testing. (19586927)
2009
25
Familial hemiplegic migraine is associated with febrile seizures in an FHM2 family with a novel de novo ATP1A2 mutation. (19874388)
2009
26
Genetic analysis of 27 Spanish patients with hemiplegic migraine, basilar-type migraine and childhood periodic syndromes. (18644040)
2008
27
Diverse functional consequences of mutations in the Na+/K+-ATPase alpha2-subunit causing familial hemiplegic migraine type 2. (18728015)
2008
28
Sporadic hemiplegic migraine: report of a case with clinical and radiological features. (18810316)
2008
29
A novel de novo nonsense mutation in ATP1A2 associated with sporadic hemiplegic migraine and epileptic seizures. (18644608)
2008
30
Recurrent ATP1A2 mutations in Portuguese families with familial hemiplegic migraine. (17952365)
2007
31
Sporadic and familial hemiplegic migraine: diagnosis and treatment. (16628531)
2006
32
Alterations in the alpha2 isoform of Na,K-ATPase associated with familial hemiplegic migraine type 2. (16037212)
2005
33
Single-fiber EMG in familial hemiplegic migraine. (15883351)
2005
34
Familial hemiplegic migraine type 1 mutations K1336E, W1684R, and V1696I alter Cav2.1 Ca2+ channel gating: evidence for beta-subunit isoform-specific effects. (15448138)
2004
35
Phenotypes of spinocerebellar ataxia type 6 and familial hemiplegic migraine caused by a unique CACNA1A missense mutation in patients from a large family. (12707077)
2003
36
Serial MRI in a case of familial hemiplegic migraine. (12669159)
2003
37
Magnetic resonance angiogram evidence of vasospasm in familial hemiplegic migraine. (12174974)
2002
38
Idiopathic intracranial hypertension presenting as hemiplegic migraine. (12222727)
2002
39
Mutation analysis of the CACNA1A calcium channel subunit gene in 27 patients with sporadic hemiplegic migraine. (12056940)
2002
40
Multimodal functional imaging of prolonged neurological deficits in a patient suffering from familial hemiplegic migraine. (12384224)
2002
41
Migraine with aura susceptibility locus on chromosome 19p13 is distinct from the familial hemiplegic migraine locus. (11735221)
2001
42
Familial hemiplegic migraine: a ion channel disorder. (11719257)
2001
43
The clinical spectrum of familial hemiplegic migraine associated with mutations in a neuronal calcium channel. (11439943)
2001
44
Motor cortex excitability in patients with migraine with aura and hemiplegic migraine. (10817446)
2000
45
Functional consequences of mutations in the human alpha1A calcium channel subunit linked to familial hemiplegic migraine. (10024348)
1999
46
A new locus for hemiplegic migraine maps to chromosome 1q31. (9371899)
1997
47
Wolff Award 1997. Involvement of a Ca2+ channel gene in familial hemiplegic migraine and migraine with and without aura. Dutch Migraine Genetics Research Group. (9329229)
1997
48
Hemiplegic migraine. (2391303)
1990
49
Unusual angiographic appearance during attack of hemiplegic migraine. (3721866)
1986
50
Hemiplegic migraine. (7288457)
1981

Variations for Hemiplegic Migraine

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Expression for genes affiliated with Hemiplegic Migraine

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Search GEO for disease gene expression data for Hemiplegic Migraine.

Pathways for genes affiliated with Hemiplegic Migraine

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Pathways related to Hemiplegic Migraine according to GeneCards Suite gene sharing:

(show all 41)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.2ATP1A2, ATP1A3, ATP1B1, ATP1B2
29.2ATP1A2, ATP1A3, ATP1B1, ATP1B2
39.2ATP1A2, ATP1A3, ATP1B1, ATP1B2
49.2ATP1A2, ATP1A3, ATP1B1, ATP1B2
59.2ATP1A2, ATP1A3, ATP1B1, ATP1B2
6
Show member pathways
9.2ATP1A2, ATP1A3, ATP1B1, ATP1B2
79.2ATP1A2, ATP1A3, ATP1B1, ATP1B2
8
Show member pathways
9.2ATP1A2, ATP1A3, ATP1B1, ATP1B2
99.2ATP1A2, ATP1A3, ATP1B1, ATP1B2
109.2ATP1A2, ATP1A3, ATP1B1, ATP1B2
119.2ATP1A2, ATP1A3, ATP1B1, ATP1B2
129.1GNB1, GNG2
139.1GNB1, GNG2
149.1CALCA, NOTCH3, OPRM1, SCN1A, SCN5A
15
Show member pathways
8.9GNB1, GNG2, PRKCSH
16
Show member pathways
8.8ATP1A2, ATP1A3, ATP1B1, ATP1B2, GNAI2
178.8ATP1A2, ATP1A3, ATP1B1, ATP1B2, SLC2A1
188.8GNAI2, GNB1, GNG2
198.8GNAI2, GNB1, GNG2
208.8GNAI2, GNB1, GNG2
21
Show member pathways
8.8GNAI2, GNB1, GNG2
22
Show member pathways
8.6ATP1A2, ATP1A3, ATP1B1, ATP1B2, SCN1A, SCN5A
23
Show member pathways
8.6CACNA1A, GNAI2, GNB1, GNG2
248.6CACNA1A, GNAI2, GNB1, GNG2
25
Show member pathways
8.5ATP1A2, ATP1A3, ATP1B1, ATP1B2, GNAI2, PRKCSH
268.5ATP1A2, ATP1A3, ATP1B1, ATP1B2, NOTCH3, SLC2A1
27
Show member pathways
8.5GNAI2, GNB1, GNG2, PRKCSH
28
Show member pathways
8.5GNAI2, GNB1, GNG2, PRKCSH
298.5GNAI2, GNB1, GNG2, PRKCSH
30
Show member pathways
8.5GNAI2, GNB1, GNG2, OPRM1
31
Show member pathways
8.5ATP1A2, ATP1A3, ATP1B1, ATP1B2, GNAI2, SCN5A
32
Show member pathways
8.5CALCA, GNAI2, GNB1, GNG2
338.5CALCA, GNAI2, GNB1, GNG2
34
Show member pathways
8.4ATP1A2, ATP1A3, ATP1B1, ATP1B2, GNAI2, SLC2A1
35
Show member pathways
8.3GNAI2, GNB1, GNG2, SLC2A1
36
Show member pathways
8.1CACNA1A, GNAI2, GNB1, GNG2, SLC2A1
378.1GNAI2, GNB1, GNG2, PRKCSH, SLC2A1
38
Show member pathways
8.0CACNA1A, GNAI2, GNB1, GNG2, SCN1A, SCN5A
39
Show member pathways
7.8CACNA1A, GNAI2, GNB1, GNG2, OPRM1, PRKCSH
40
Show member pathways
7.4ATP1A2, ATP1A3, ATP1B1, ATP1B2, GNB1, GNG2
41
Show member pathways
7.4ATP1B1, ATP1B2, CACNA1A, CALCA, GNAI2, GNB1

GO Terms for genes affiliated with Hemiplegic Migraine

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Cellular components related to Hemiplegic Migraine according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1voltage-gated sodium channel complexGO:000151810.6SCN1A, SCN5A
2T-tubuleGO:003031510.3ATP1A2, SCN1A, SCN5A
3intercalated discGO:001470410.0ATP1A2, ATP1B1, SCN1A, SCN5A
4sodium:potassium-exchanging ATPase complexGO:00058909.8ATP1A2, ATP1A3, ATP1B1, ATP1B2
5caveolaGO:00059019.8ATP1A2, ATP1B1, SCN5A, SLC2A1
6sarcolemmaGO:00423839.6ATP1A2, ATP1B1, SCN5A
7myelin sheathGO:00432099.5ATP1A2, ATP1A3, ATP1B1, GNB1
8heterotrimeric G-protein complexGO:00058349.5GNAI2, GNB1, GNG2
9extracellular vesicleGO:19035619.2ATP1A2, ATP1A3, ATP1B1, GNAI2, GNB1
10membraneGO:00160206.2ATP1A2, ATP1B1, CACNA1A, GNAI2, GNB1, GNG2
11plasma membraneGO:00058865.2ATP1A2, ATP1A3, ATP1B1, ATP1B2, CACNA1A, GNAI2

Biological processes related to Hemiplegic Migraine according to GeneCards Suite gene sharing:

(show all 34)
idNameGO IDScoreTop Affiliating Genes
1cellular response to steroid hormone stimulusGO:007138310.6ATP1A2, ATP1A3
2response to glycosideGO:190341610.6ATP1A2, ATP1A3
3negative regulation of cytosolic calcium ion concentrationGO:005148110.6ATP1A2, OPRM1
4potassium ion import across plasma membraneGO:199057310.5ATP1A2, ATP1B1
5regulation of cardiac muscle cell contractionGO:008600410.5ATP1A2, SCN5A
6membrane depolarization during cardiac muscle cell action potentialGO:008601210.5ATP1A2, SCN5A
7relaxation of cardiac muscleGO:005511910.5ATP1A2, ATP1B1
8response to painGO:004826510.3CACNA1A, CALCA
9neuromuscular process controlling postureGO:005088410.3PRRT2, SCN1A
10positive regulation of potassium ion transmembrane transporter activityGO:190101810.2ATP1B1, ATP1B2
11positive regulation of sodium ion export from cellGO:190327810.2ATP1B1, ATP1B2
12positive regulation of potassium ion importGO:190328810.2ATP1B1, ATP1B2
13membrane depolarization during action potentialGO:008601010.2CACNA1A, SCN1A, SCN5A
14regulation of ion transmembrane transportGO:003476510.2CACNA1A, SCN1A, SCN5A
15G-protein coupled acetylcholine receptor signaling pathwayGO:000721310.0GNAI2, GNB1
16sodium ion transmembrane transportGO:003572510.0ATP1A2, ATP1A3, SCN1A, SCN5A
17membrane repolarizationGO:008600910.0ATP1A2, ATP1B1, ATP1B2
18cellular response to catecholamine stimulusGO:00718709.8GNB1, GNG2
19cellular response to prostaglandin E stimulusGO:00713809.8GNB1, GNG2
20potassium ion transportGO:00068139.8ATP1A2, ATP1A3, ATP1B1, ATP1B2
21cellular sodium ion homeostasisGO:00068839.8ATP1A2, ATP1A3, ATP1B1, ATP1B2
22potassium ion importGO:00101079.8ATP1A2, ATP1A3, ATP1B1, ATP1B2
23sodium ion export from cellGO:00363769.8ATP1A2, ATP1A3, ATP1B1, ATP1B2
24cell communication by electrical coupling involved in cardiac conductionGO:00860649.8ATP1A2, ATP1A3, ATP1B1, ATP1B2
25cellular potassium ion homeostasisGO:00300079.7ATP1A2, ATP1A3, ATP1B1, ATP1B2
26cardiac muscle contractionGO:00600489.6ATP1A2, ATP1B1, SCN5A
27positive regulation of cytosolic calcium ion concentrationGO:00072049.5CACNA1A, CALCA, GNB1, OPRM1
28ion transmembrane transportGO:00342209.4ATP1A2, ATP1A3, ATP1B1, ATP1B2, CACNA1A
29adenylate cyclase-activating dopamine receptor signaling pathwayGO:00071919.1GNB1, GNG2, OPRM1
30sodium ion transportGO:00068149.0ATP1A2, ATP1A3, ATP1B1, ATP1B2, SCN1A, SCN5A
31energy reserve metabolic processGO:00061129.0CACNA1A, GNB1, GNG2, SLC2A1
32synaptic transmissionGO:00072688.5CACNA1A, GNAI2, GNB1, GNG2, OPRM1
33transmembrane transportGO:00550858.3ATP1A2, ATP1A3, ATP1B1, ATP1B2, CACNA1A, SCN1A
34blood coagulationGO:00075967.6ATP1B1, ATP1B2, GNAI2, GNB1, GNG2

Molecular functions related to Hemiplegic Migraine according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1voltage-gated sodium channel activityGO:000524810.3SCN1A, SCN5A
2steroid hormone bindingGO:199023910.1ATP1A2, ATP1A3
3potassium ion bindingGO:003095510.1ATP1A2, ATP1B1
4sodium ion bindingGO:003140210.1ATP1A2, ATP1B1
5G-protein beta-subunit bindingGO:00316819.8GNG2, OPRM1
6ATPase activator activityGO:00016719.6ATP1B1, ATP1B2
7sodium:potassium-exchanging ATPase activityGO:00053919.1ATP1A2, ATP1A3, ATP1B1, ATP1B2

Sources for Hemiplegic Migraine

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet