MCID: HMP006
MIFTS: 45

Hemiplegic Migraine malady

Categories: Genetic diseases, Rare diseases, Neuronal diseases

Aliases & Classifications for Hemiplegic Migraine

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Aliases & Descriptions for Hemiplegic Migraine:

Name: Hemiplegic Migraine 46 66
 
Migraine Hemiplegic 48

Classifications:



Summaries for Hemiplegic Migraine

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NIH Rare Diseases:46 Hemiplegic migraine (hm) is a rare type of migraine with aura that occurs with motor weakness during the aura. there are two types of hm which are distinguished based on the family history: familial hemiplegic migraine (fhm, in which at least one other family member has the condition) and sporadic hemiplegic migraine (shm, in which there is no family history). signs and symptoms vary but may include visual disturbances, sensory loss, difficulty with speech, weakness on one side of the body, confusion, and impaired consciousness. severe attacks may occur in both types with prolonged hemiplegia, coma, fever and/or seizures. fhm may be caused by a mutation in any of several genes and is inherited in an autosomal dominant manner. last updated: 11/17/2014

MalaCards based summary: Hemiplegic Migraine, also known as migraine hemiplegic, is related to migraine, familial hemiplegic, 3 and alternating hemiplegia of childhood, and has symptoms including headache An important gene associated with Hemiplegic Migraine is ATP1A2 (ATPase Na+/K+ Transporting Subunit Alpha 2), and among its related pathways are Rapid glucocorticoid signaling and Nongenotropic Androgen signaling. Affiliated tissues include brain, testes and trigeminal ganglion, and related mouse phenotypes are respiratory system and normal.

Related Diseases for Hemiplegic Migraine

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Diseases in the Hemiplegic Migraine family:

Migraine, Familial Hemiplegic, 2 Migraine, Familial Hemiplegic, 3
Migraine, Familial Hemiplegic, 1 Familial Hemiplegic Migraine
Sporadic Hemiplegic Migraine Familial or Sporadic Hemiplegic Migraine

Diseases related to Hemiplegic Migraine via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 70)
idRelated DiseaseScoreTop Affiliating Genes
1migraine, familial hemiplegic, 333.6MGR6, SCN1A
2alternating hemiplegia of childhood31.1ATP1A2, ATP1A3, CACNA1A, CALCA, SLC2A1
3familial hemiplegic migraine12.7
4sporadic hemiplegic migraine12.5
5familial or sporadic hemiplegic migraine12.3
6migraine, familial hemiplegic, 111.8
7migraine, familial hemiplegic, 211.8
8episodic ataxia10.8
9epilepsy, generalized, with febrile seizures plus, type 210.6MGR6, SCN1A
10surfactant dysfunction10.5ATP1A2, CACNA1A, SCN1A
11ataxia10.5
12cerebritis10.5
13sarcocystosis10.5ATP1A2, CACNA1A, PRRT2
14neuronitis10.5
15double fingernail of fifth finger10.4SCN1A, SLC2A1
16epilepsy10.3
17chromosome 8-derived supernumerary ring /marker10.3ATP1A2, CACNA1A, PRRT2, SCN1A
18brachydactyly, type e10.3CACNA1A, MGR6, SCN1A
19penis sarcoma10.3GNB1, PRRT2
20cerebellar ataxia10.3
21hemiplegia10.3
22spinal cord infarction10.3GNB1, PRRT2, SCN1A
23glut1 deficiency syndrome 210.3PRRT2, SLC2A1
24encephalopathy10.3
25juvenile absence epilepsy10.3ATP1A2, ATP1A3, PRRT2, SCN1A
26hereditary neuropathies10.2ATP1A2, CACNA1A, CALCA, SCN1A
27kallmann syndrome 310.2ATP1A3, ATP1B2
28pinched nerve10.2PRRT2, SLC2A1
29x-linked protoporphyria10.2ATP1A3, ATP1B2
303-methylcrotonyl-coa carboxylase deficiency10.2PRRT2, SLC2A1
31moyamoya disease10.1
32migraine with aura10.1
33cadasil10.1
34weber syndrome10.1
35migraine with or without aura 110.1
36alternating hemiplegia of childhood 210.1
37hemiplegia alterans10.1
38myelocytic leukemia-like syndrome, familial, chronic10.1CACNA1A, CALCA
39episodic ataxia, type 210.0
40patent foramen ovale10.0
41retinitis10.0
42dystonia10.0
43retinal degeneration10.0
44meningitis10.0
45pelvic inflammatory disease10.0ATP1A2, CACNA1A, NOTCH3, PRRT2, SCN1A
46angiomyolipoma10.0CACNA1A, NOTCH3, SCN1A
47cystic fibrosis9.9
48capos syndrome9.9
49crest syndrome9.9
50arteriovenous malformation9.9

Graphical network of the top 20 diseases related to Hemiplegic Migraine:



Diseases related to hemiplegic migraine

Symptoms for Hemiplegic Migraine

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UMLS symptoms related to Hemiplegic Migraine:


headache

Drugs & Therapeutics for Hemiplegic Migraine

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Drugs for Hemiplegic Migraine (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
TopiramatePhase 2, Phase 324497240-79-45284627
Synonyms:
-D-fructopyranose deriv.
.beta.-D-Fructopyranose, 2,3:4,5-bis-O-(1-methylethylidene)-, sulfamate (9CI)
2,3-4,5-bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate
2,3:4,5-Bis-O-(1-methylethylidene) .beta.-D-fructopyranose sulfamate
2,3:4,5-Bis-O-(1-methylethylidene)-36-D-fructo-pyranose sulfamate
2,3:4,5-Bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate
2,3:4,5-Di- O -isopropylidene-(beta)-D-fructopyranose sulfamate
2,3:4,5-Di-O-isopropylidene-beta-D-fructopyranose sulfamate
5H-Bis[1,3]dioxolo[4,5-b:4',5'-d]pyran, .beta.
97240-79-4
AKOS000424547
BIDD:GT0854
BIDD:PXR0127
BRN 5988957
BSPBio_002306
C052342
C07502
C12H21NO8S
CBChromo1_000352
CHEBI:129573
CHEMBL220492
CID5284627
CPD000466325
Cilag brand of topiramate
D00537
DB00273
Epitoma
Epitomax
HMS1922H06
HMS2051L09
HMS2093D20
HSDB 7531
Janssen brand of topiramate
KS-1122
KW-6485
LS-187392
LS-69764
MLS000759431
MLS001424070
McN 4853
McN-4853
MolPort-001-615-062
MolPort-002-885-869
NCGC00178714-01
 
Ortho brand of topiramate
RWJ 17021
RWJ-17021
RWJ-17021-000
S1438_Selleck
SAM001246601
SMR000466325
SPBio_000995
SPECTRUM1505801
STOCK1N-71037
Spectrum2_001128
T0575_SIGMA
TL8006021
TOR
TPM
Tipiramate
Tipiramate [French]
Tipiramato
Tipiramato [Spanish]
Topamac
Topamax
Topamax (TN)
Topamax Sprinkle
Topamax, Topiramate
Topimax
Topina
Topiramate
Topiramate (JAN/USAN/INN)
Topiramate (TPM)
Topiramate / Placebo
Topiramate [USAN:BAN:INN]
Topiramato
Topiramato [INN-Spanish]
Topiramatum
Topiramatum [INN-Latin]
Topiramic acid
Topomax
UNII-0H73WJJ391
USL-255
[(3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl]methyl sulfamate
beta-D-Fructopyranose, 2,3:4,5-bis-O-(1-methylethylidene)-, sulfamate
beta.-D-Fructopyranose, 2,3:4,5-bis-O-(1-methylethylidene)-, 1-sulfamate
topiramate
topiramate tablet
topiramatum [Latin]
2
Salmon Calcitonin9247931-85-116129616
Synonyms:
135506-95-5
47931-85-1
Astronin
Biocalcin
Bionocalcin
C028815
C06865
C145H239N43O48S2
CALCITONIN, SALMON
Cadens
Calciben
Calcihexal
Calcimar
Calcimar (TN)
Calcimonta
Calcinil
Calcioton
Calcitonin (Salmon Synthetic)
Calcitonin (salmon)
Calcitonin 1 precursor
Calcitonin Salmon
Calcitonin [USAN:INN:BAN:JAN]
Calcitonin salmon
Calcitonin salmon (USAN/INN)
Calcitonin salmon (synthesis)
Calcitonin salmon (synthesis) (JAN)
Calcitonin salmon recombinant
Calcitonin vom lachs
Calcitonin, salmar
Calcitonin, salmon
Calcitonin, salmon, for bioassay
Calcitonin,salmon
Calcitonin-salmon
Calcitonina
Calcitonine de saumon
Calcitoran
Calco
Calogen
Calsynar
Calsynar Lyo L
Caltine
Casalm
Catonin
Cibacalcin
Cibacalcine
Citonina
 
D00249
EINECS 256-342-8
Eptacalcin
Forcaltonin
Fortical
Fortical (TN)
Ipocalcin
Isi-calcin
Kalsimin
Karil
LS-48624
Miacalcic
Miacalcin
Miacalcin (TN)
Miracalcic
Oseototal
Osseocalcina
Osteobion
Osteovis
Ostosalm
Ostostabil
Porostenina
Prontocalcin
Quosten
Riostin
Rulicalcin
Salcat
Salcatonin
Salcatyn
Salmocalcin
Salmofar
Salmon calcitonin
Salmon calcitonin I
Salmon calcitonin-(I-32)
Salmotonin
Sical
Stalcin
Staporos
Steocin
TZ-CT
Thyrocalcitonin (salmon)
Tonocalcin
UNII-7SFC6U2VI5
Ucecal
recombinant salmon calcitonin
salmon calcitonin (1-32)
synthetic salmon calcitonin
3CALCITONIN GENE-RELATED PEPTIDE92
4calcitonin104
5
Nitroglycerin14655-63-04510
Synonyms:
1,2,3-Propanetrioltrinitrate
1,2,3-Propanetriyl nitrate
100292-13-5
105469-31-6
55-63-0
80066-48-4
8013-23-8
9010-02-0
AC1L1IBV
Adesitrin
Aldonitrin
Angibid
Angiolingual
Angiplex
Anglix
Angonist
Angorin
Anogesic
Aquo-Trimitrosan
BIDD:GT0142
BRN 1802063
Blasting gelatin
Blasting oil
Buccal
Buccard
C07455
C3H5N3O9
CCRIS 4089
CHEBI:28787
CHEMBL730
CID4510
CPD-143
Cardabid
Cardamist
Cardinit
Cardiodisco
Cellegesic
Chitamite
Colenitral
Cordipatch
Corditrine
Coro-Nitro
D00515
D005996
DB00727
Dauxona
Deponit
Deponit 5
Deponit TTS 10
Deponit TTS 5
Deponit-5
Diafusor
Discotrine
Dynamite
EINECS 200-240-8
Epinitril
GTN
GTN-Pohl
Gepan Nitroglicerin
Gilucor nitro
Gilustenon
Glonoin
Glycerin trinitrate
Glycerine trinitrate
Glycerintrinitrate
Glycerol trinitrate
Glycerol, nitric acid triester
Glyceroli trinitratis
Glyceroltrinitraat
Glyceroltrinitrat
Glyceryl
Glyceryl nitrate
Glyceryl trinitrate
Glycerylnitrat
Glytrin
HMS2094M15
HSDB 30
Herwicard
Herzer
IMX-150
Klavikordal
LS-7741
Lenitral
Lentonitrina
MED-2002
MQX-503
Mi-Trates
Millisrol
Minitram
Minitran
Minitran (TN)
Minitro
Mionitrat
Myocon
Myoglycerin
Myovin
NG
NITRO IV
NK-843
NTG
Natispray
Neos nitro OPT
Niglin
Niglycon
Niong
Niong Retard
Nirmin
Nit-Ret
Nitora
Nitradisc
Nitradisc Pad
Nitradisc TTS
Nitrangin
Nitrek
Nitriderm
Nitriderm TTS
Nitrine-TDC
Nitro Bid
Nitro Dur
Nitro Dur TTS
Nitro Mack Retard
Nitro Retard
Nitro Rorer
Nitro-Bid
Nitro-Dur 10
Nitro-Dur 5
Nitro-Gesanit Retard
Nitro-M-Bid
Nitro-Mack Retard
Nitro-Par
Nitro-Pflaster
Nitro-Span
Nitro-Time
Nitro-bid (TN)
Nitro-dur
Nitro-dur (TN)
Nitro-lent
NitroBid
NitroCor
 
NitroDur
NitroMist
NitroQuick
NitroQuik
Nitroard
Nitrobaat
Nitrobid Oint
Nitrobukal
Nitrocap
NitrocapT.D
NitrocapT.D.
Nitrocard
Nitrocerin
Nitrocine
Nitrocine 5
Nitroclyn
Nitrocontin
Nitrocontin Continus
Nitrocot
Nitroderm
Nitroderm TTS
Nitroderm TTS Ext
Nitroderm TTS-5
Nitrodisc
Nitrodyl
Nitrodyl TTS
Nitrogard
Nitrogard-SR
Nitroglicerina
Nitrogliceryna
Nitroglin
Nitroglycerin
Nitroglycerin (NG)
Nitroglycerin ointment
Nitroglycerin-ACC
Nitroglycerine
Nitroglycerol
Nitroglyn
Nitroject
Nitrol Ointment
Nitrolan
Nitroletten
Nitrolin
Nitrolingual
Nitrolingual Spray
Nitrolowe
Nitromack Retard
Nitromed
Nitromel
Nitromex
Nitromint
Nitromint Aerosol
Nitromint Retard
Nitromist
Nitromist (TN)
Nitronal Aqueous
Nitronet
Nitrong
Nitrong Retard
Nitrong parenteral
Nitrong-SR
Nitropatch
Nitropen
Nitropercuten
Nitroperlinit
Nitroplast
Nitroprol
Nitropront
Nitroprontan
Nitrorectal
Nitroretard
Nitrorex
Nitrospan
Nitrostabilin
Nitrostat
Nitrovis
Nitrozell retard
Nysconitrine
Percutol
Percutol Oint
Percutol Oint.
Perganit
Perglottal
Perlinganit
Plastranit
Polnitrin
Propane-1,2,3-triyl trinitrate
RCRA waste no. P081
Ratiopharm
Rectogesic
SDM No. 17
SK-106N
SK-866
SK-878
Soup
Spirit of glonoin
Susadrin
Suscard
Sustac
Sustak
Sustonit
TNG
Temponitrin
Top-Nitro
Transderm Nitro
Transderm nitro
Transderm-N TTS
Transderm-Nitro TTS
Transderm-nitro
Transderm-nitro (TN)
Transiderm-nitro
Tridil
Tridil sublin
Trinalgon
Trinipatch
Triniplas
Trinitrate, Glyceryl
Trinitrin
Trinitrin Tablets
Trinitrina Erba
Trinitrine
Trinitroglycerin
Trinitroglycerol
Trinitrol
Trinitrolong
Trinitron
Trinitrosan
Turicard
UN0143
UN0144
UN1204
UN3064
UN3319
UNII-G59M7S0WS3
Vascana
Vasoglyn
Vasolator
Vernies
Willong
c0061
nitroglycerin
6
Pancrelipase91753608-75-6
Synonyms:
1,4-alpha-D- glucan glucanohydrolase
PA
 
Pancreatic alpha-amylase precursor
Pancrelipase (amylase
lipase
protease)
7pancreatin917

Interventional clinical trials:

idNameStatusNCT IDPhase
1Dose Comparison Study of Topiramate in Pediatric Subjects With Basilar/Hemiplegic MigraineCompletedNCT00131443Phase 2, Phase 3
2A Study of Topiramate in Pediatric Subjects With Basilar/Hemiplegic MigraineCompletedNCT00158002Phase 2
3Glyceryl-Trinitrate-Induced Headache in Patients With Familial Hemiplegic MigraineCompletedNCT00541736
4Calcitonin Gene Related Peptide-Induced Headache in Patients With Familial Hemiplegic Migraine Type 1 and 2.CompletedNCT00358839
5Glyceryl-Trinitrate-Induced Headache in Patients With Familial Hemiplegic Migraine Type 1 and 2CompletedNCT00257985
6Calcitonin Gene-related Peptide in Familial Hemiplegic Migraine (FHM) and Migraine With Aura (MA)CompletedNCT00687947
7Genetic Analysis of Children With Cyclic Vomiting Syndrome (CVS) and MigrainesRecruitingNCT00727974

Search NIH Clinical Center for Hemiplegic Migraine

Genetic Tests for Hemiplegic Migraine

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Anatomical Context for Hemiplegic Migraine

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MalaCards organs/tissues related to Hemiplegic Migraine:

34
Brain, Testes, Trigeminal ganglion, Tongue, Thalamus, Kidney, Cortex

Animal Models for Hemiplegic Migraine or affiliated genes

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MGI Mouse Phenotypes related to Hemiplegic Migraine:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.6ATP1A2, ATP1A3, ATP1B1, CACNA1A, GNAI2, GNB1
2MP:00028737.8ATP1A2, ATP1B1, CACNA1A, GNAI2, NOTCH3, OPRM1
3MP:00053866.9ATP1A2, ATP1A3, ATP1B2, CACNA1A, GNAI2, GNB1
4MP:00036316.8ATP1A2, ATP1A3, ATP1B2, CACNA1A, GNAI2, GNB1
5MP:00107686.3ATP1A2, ATP1A3, ATP1B1, ATP1B2, CACNA1A, GNAI2

Publications for Hemiplegic Migraine

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Articles related to Hemiplegic Migraine:

(show top 50)    (show all 390)
idTitleAuthorsYear
1
Abnormal synaptic Ca(2+) homeostasis and morphology in cortical neurons of familial hemiplegic migraine type 1 mutant mice. (26032020)
2015
2
Familial hemiplegic migraine type-1 mutated cav2.1 calcium channels alter inhibitory and excitatory synaptic transmission in the lateral superior olive of mice. (25481823)
2015
3
A case report of sporadic hemiplegic migraine associated cerebral hypoperfusion: comparison of arterial spin labeling and dynamic susceptibility contrast perfusion MR imaging. (26250760)
2015
4
PRRT2 and hemiplegic migraine: a complex association. (24928127)
2014
5
Hemiplegic migraine: neuroimaging findings during a hemiplegic migraine attack. (24512003)
2014
6
Familial hemiplegic migraine and spreading depression. (25143767)
2014
7
Changes in (99m)Tc-ECD SPECT and magnetic resonance angiography with sporadic hemiplegic migraine in a child. (24662647)
2014
8
A novel SLC2A1 mutation linking hemiplegic migraine with alternating hemiplegia of childhood. (24824604)
2014
9
Magnetic Resonance Angiography Evidence of Vasospasm in Children With Suspected Acute Hemiplegic Migraine. (23594822)
2013
10
Transient unilateral spatial neglect during aura in a woman with sporadic hemiplegic migraine. (23674829)
2013
11
Stroke and familial hemiplegic migraine. (22608661)
2012
12
Transient nonverbal learning disorder in a child suffering from Familial Hemiplegic Migraine. (21908445)
2011
13
Acute striatal necrosis in hemiplegic migraine with de novo CACNA1A mutation. (22082423)
2011
14
Trigger factors for familial hemiplegic migraine. (21784774)
2011
15
One case of sporadic hemiplegic migraine with multiple pulmonary arteriovenous malformation. (21246241)
2011
16
De novo mutations in ATP1A2 and CACNA1A are frequent in early-onset sporadic hemiplegic migraine. (20837964)
2010
17
Link between confusional migraine, hemiplegic migraine and episodic ataxia type 2: hypothesis, family genealogy, gene typing and classification. (19624685)
2010
18
Large scale calcium channel gene rearrangements in episodic ataxia and hemiplegic migraine: implications for diagnostic testing. (19586927)
2009
19
Familial hemiplegic migraine is associated with febrile seizures in an FHM2 family with a novel de novo ATP1A2 mutation. (19874388)
2009
20
Diverse functional consequences of mutations in the Na+/K+-ATPase alpha2-subunit causing familial hemiplegic migraine type 2. (18728015)
2008
21
Sporadic hemiplegic migraine: report of a case with clinical and radiological features. (18810316)
2008
22
A novel de novo nonsense mutation in ATP1A2 associated with sporadic hemiplegic migraine and epileptic seizures. (18644608)
2008
23
Hemiplegic migraine: hyperperfusion and abortive therapy with intravenous verapamil. (17614229)
2008
24
Effects of familial hemiplegic migraine type 1 mutations on neuronal P/Q-type Ca2+ channel activity and inhibitory synaptic transmission. (15699344)
2005
25
Familial hemiplegic migraine type 1 mutations K1336E, W1684R, and V1696I alter Cav2.1 Ca2+ channel gating: evidence for beta-subunit isoform-specific effects. (15448138)
2004
26
Single-fiber EMG in familial hemiplegic migraine. (15557518)
2004
27
Serial MRI in a case of familial hemiplegic migraine. (12669159)
2003
28
Evidence for a separate type of migraine with aura: sporadic hemiplegic migraine. (12601098)
2003
29
New discoveries about the second gene for familial hemiplegic migraine, ATP1A2. (14636773)
2003
30
Treatment of sporadic hemiplegic migraine with calcium-channel blocker verapamil. (12963781)
2003
31
Magnetic resonance angiogram evidence of vasospasm in familial hemiplegic migraine. (12174974)
2002
32
Multimodal functional imaging of prolonged neurological deficits in a patient suffering from familial hemiplegic migraine. (12384224)
2002
33
A population-based study of familial hemiplegic migraine suggests revised diagnostic criteria. (12023326)
2002
34
Familial hemiplegic migraine mutations increase Ca(2+) influx through single human CaV2.1 channels and decrease maximal CaV2.1 current density in neurons. (12235360)
2002
35
Japanese cases of familial hemiplegic migraine with cerebellar ataxia carrying a T666M mutation in the CACNA1A gene. (11971066)
2002
36
Migraine with aura susceptibility locus on chromosome 19p13 is distinct from the familial hemiplegic migraine locus. (11735221)
2001
37
The clinical spectrum of familial hemiplegic migraine associated with mutations in a neuronal calcium channel. (11439943)
2001
38
Familial hemiplegic migraine and its abortive therapy with intravenous verapamil. (11706128)
2001
39
Motor cortex excitability in patients with migraine with aura and hemiplegic migraine. (10817446)
2000
40
Functional consequences of mutations in the human alpha1A calcium channel subunit linked to familial hemiplegic migraine. (10024348)
1999
41
Familial hemiplegic migraine with cerebellar ataxia and paroxysmal psychosis. (10202246)
1999
42
Wolff Award 1997. Involvement of a Ca2+ channel gene in familial hemiplegic migraine and migraine with and without aura. Dutch Migraine Genetics Research Group. (9329229)
1997
43
Familial hemiplegic migraine: involvement of a calcium neuronal channel. (9436352)
1997
44
Common heredity of familial hemiplegic migraine and basilar artery migraine? (8706104)
1995
45
A gene for familial hemiplegic migraine maps to chromosome 19. (8220421)
1993
46
Hemiplegic migraine following third molar extractions under intravenous sedation: report of a case. (2913255)
1989
47
Unusual angiographic appearance during attack of hemiplegic migraine. (3721866)
1986
48
Hemiplegic migraine and progressive hemifacial atrophy. (4026238)
1985
49
Drugs for alternating hemiplegic migraine. (6149366)
1984
50
Familial hemiplegic migraine. (13085199)
1953

Variations for Hemiplegic Migraine

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Expression for genes affiliated with Hemiplegic Migraine

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Search GEO for disease gene expression data for Hemiplegic Migraine.

Pathways for genes affiliated with Hemiplegic Migraine

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Pathways related to Hemiplegic Migraine according to GeneCards Suite gene sharing:

(show all 37)
idSuper pathwaysScoreTop Affiliating Genes
19.6GNB1, GNG2
29.6GNB1, GNG2
39.2GNAI2, GNB1, GNG2
49.2GNAI2, GNB1, GNG2
59.2GNAI2, GNB1, GNG2
69.2GNAI2, GNB1, GNG2
7
Show member pathways
9.2GNAI2, GNB1, GNG2
8
Show member pathways
9.2GNAI2, GNB1, GNG2
99.1CALCA, NOTCH3, OPRM1, SCN1A, SCN5A
10
Show member pathways
9.0CACNA1A, GNAI2, GNB1, GNG2
119.0CACNA1A, GNAI2, GNB1, GNG2
129.0CALCA, GNAI2, GNB1, GNG2
13
Show member pathways
9.0ATP1A2, ATP1A3, ATP1B1, ATP1B2
149.0ATP1A2, ATP1A3, ATP1B1, ATP1B2
15
Show member pathways
9.0ATP1A2, ATP1A3, ATP1B1, ATP1B2
169.0ATP1A2, ATP1A3, ATP1B1, ATP1B2
179.0ATP1A2, ATP1A3, ATP1B1, ATP1B2
189.0ATP1A2, ATP1A3, ATP1B1, ATP1B2
199.0ATP1A2, ATP1A3, ATP1B1, ATP1B2
209.0ATP1A2, ATP1A3, ATP1B1, ATP1B2
219.0ATP1A2, ATP1A3, ATP1B1, ATP1B2
229.0ATP1A2, ATP1A3, ATP1B1, ATP1B2
23
Show member pathways
8.9GNAI2, GNB1, GNG2, OPRM1
24
Show member pathways
8.8GNAI2, GNB1, GNG2, SLC2A1
25
Show member pathways
8.6CACNA1A, GNAI2, GNB1, GNG2, SLC2A1
26
Show member pathways
8.6ATP1A2, ATP1A3, ATP1B1, ATP1B2, GNAI2
27
Show member pathways
8.6ATP1A2, ATP1A3, ATP1B1, ATP1B2, GNAI2
28
Show member pathways
8.5ATP1A2, ATP1A3, ATP1B1, ATP1B2, SLC2A1
298.5ATP1A2, ATP1A3, ATP1B1, ATP1B2, SLC2A1
30
Show member pathways
8.5CACNA1A, GNAI2, GNB1, GNG2, SCN1A, SCN5A
31
Show member pathways
8.5CACNA1A, GNAI2, GNB1, GNG2, OPRM1, SCN1A
32
Show member pathways
8.5ATP1A2, ATP1A3, ATP1B1, ATP1B2, SCN1A, SCN5A
33
Show member pathways
8.5ATP1A2, ATP1A3, ATP1B1, ATP1B2, SCN1A, SCN5A
34
Show member pathways
8.3ATP1A2, ATP1A3, ATP1B1, ATP1B2, GNAI2, SCN5A
358.2ATP1A2, ATP1A3, ATP1B1, ATP1B2, NOTCH3, SLC2A1
36
Show member pathways
7.7ATP1B1, ATP1B2, CACNA1A, CALCA, GNAI2, GNB1
37
Show member pathways
7.7ATP1A2, ATP1A3, ATP1B1, ATP1B2, GNB1, GNG2

GO Terms for genes affiliated with Hemiplegic Migraine

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Cellular components related to Hemiplegic Migraine according to GeneCards Suite gene sharing:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1voltage-gated sodium channel complexGO:000151810.7SCN1A, SCN5A
2T-tubuleGO:003031510.5ATP1A2, SCN1A, SCN5A
3heterotrimeric G-protein complexGO:00058349.8GNAI2, GNB1, GNG2
4intercalated discGO:00147049.7ATP1A2, ATP1B1, SCN1A, SCN5A
5sodium:potassium-exchanging ATPase complexGO:00058909.7ATP1A2, ATP1A3, ATP1B1, ATP1B2
6myelin sheathGO:00432099.6ATP1A2, ATP1A3, ATP1B1, GNB1
7caveolaGO:00059019.5ATP1A2, ATP1B1, SCN5A, SLC2A1
8sarcolemmaGO:00423839.5ATP1A2, ATP1A3, ATP1B1, OPRM1, SCN5A
9dendriteGO:00304259.4CACNA1A, GNAI2, GNB1, OPRM1
10extracellular vesicleGO:19035619.3ATP1A2, ATP1A3, ATP1B1, GNAI2, GNB1
11intracellularGO:00056228.7ATP1B1, CALCA, GNB1, PRKCSH, SCN5A, SLC2A1
12membraneGO:00160207.4ATP1A2, ATP1B1, GNAI2, GNB1, GNG2, OPRM1
13plasma membraneGO:00058865.6ATP1A2, ATP1A3, ATP1B1, ATP1B2, CACNA1A, GNAI2

Biological processes related to Hemiplegic Migraine according to GeneCards Suite gene sharing:

(show all 30)
idNameGO IDScoreTop Affiliating Genes
1response to glycosideGO:190341610.6ATP1A2, ATP1A3
2cellular response to steroid hormone stimulusGO:007138310.6ATP1A2, ATP1A3
3regulation of cardiac muscle cell contractionGO:008600410.6ATP1A2, SCN5A
4membrane depolarization during cardiac muscle cell action potentialGO:008601210.5ATP1A2, SCN5A
5neuromuscular process controlling postureGO:005088410.4PRRT2, SCN1A
6potassium ion import across plasma membraneGO:199057310.4ATP1A2, ATP1B1
7response to painGO:004826510.4CACNA1A, CALCA
8relaxation of cardiac muscleGO:005511910.3ATP1A2, ATP1B1
9membrane depolarization during action potentialGO:008601010.3CACNA1A, SCN1A, SCN5A
10cellular response to prostaglandin E stimulusGO:007138010.2GNB1, GNG2
11G-protein coupled acetylcholine receptor signaling pathwayGO:000721310.2GNAI2, GNB1
12potassium ion transportGO:000681310.0ATP1A2, ATP1A3, ATP1B1
13positive regulation of sodium ion export from cellGO:190327810.0ATP1B1, ATP1B2
14ATP hydrolysis coupled transmembrane transportGO:009066210.0ATP1B1, ATP1B2
15positive regulation of potassium ion transmembrane transporter activityGO:190101810.0ATP1B1, ATP1B2
16positive regulation of potassium ion importGO:190328810.0ATP1B1, ATP1B2
17membrane repolarizationGO:00860099.8ATP1A2, ATP1B1, ATP1B2
18cellular response to catecholamine stimulusGO:00718709.6GNB1, GNG2
19cardiac muscle contractionGO:00600489.6ATP1A2, ATP1A3, ATP1B1, SCN5A
20potassium ion importGO:00101079.5ATP1A2, ATP1A3, ATP1B1, ATP1B2
21sodium ion export from cellGO:00363769.5ATP1A2, ATP1A3, ATP1B1, ATP1B2
22establishment or maintenance of transmembrane electrochemical gradientGO:00102489.5ATP1A2, ATP1A3, ATP1B1, ATP1B2
23sodium ion transportGO:00068149.5ATP1A2, ATP1A3, ATP1B1, SCN1A, SCN5A
24cellular sodium ion homeostasisGO:00068839.5ATP1A2, ATP1A3, ATP1B1, ATP1B2
25cell communication by electrical coupling involved in cardiac conductionGO:00860649.5ATP1A2, ATP1A3, ATP1B1, ATP1B2
26cellular potassium ion homeostasisGO:00300079.5ATP1A2, ATP1A3, ATP1B1, ATP1B2
27ion transmembrane transportGO:00342209.2ATP1A2, ATP1A3, ATP1B1, ATP1B2
28regulation of cardiac conductionGO:19037799.1ATP1A2, ATP1A3, ATP1B1, ATP1B2
29adenylate cyclase-activating dopamine receptor signaling pathwayGO:00071919.0GNB1, GNG2, OPRM1
30protein foldingGO:00064579.0GNAI2, GNB1, GNG2, PRKCSH

Molecular functions related to Hemiplegic Migraine according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1steroid hormone bindingGO:199023910.4ATP1A2, ATP1A3
2voltage-gated sodium channel activityGO:000524810.2SCN1A, SCN5A
3potassium ion bindingGO:003095510.1ATP1A2, ATP1B1
4G-protein beta-subunit bindingGO:00316819.8GNG2, OPRM1
5sodium ion bindingGO:00314029.8ATP1A2, ATP1B1, SCN1A
6ATPase activator activityGO:00016719.4ATP1B1, ATP1B2
7sodium:potassium-exchanging ATPase activityGO:00053919.2ATP1A2, ATP1A3, ATP1B1, ATP1B2

Sources for Hemiplegic Migraine

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet