MCID: HMP006
MIFTS: 50

Hemiplegic Migraine malady

Genetic diseases, Rare diseases, Neuronal diseases categories

Summaries for Hemiplegic Migraine

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NIH Rare Diseases:41 Hemiplegic migraine (hm) is a rare type of migraine with aura that occurs with motor weakness during the aura. there are two types of hm which are distinguished based on the family history: familial hemiplegic migraine (fhm, in which at least one other family member has the condition) and sporadic hemiplegic migraine (shm, in which there is no family history). signs and symptoms vary but may include visual disturbances, sensory loss, difficulty with speech, weakness on one side of the body, confusion, and impaired consciousness. severe attacks may occur in both types with prolonged hemiplegia, coma, fever and/or seizures. fhm may be caused by a mutation in any of several genes and is inherited in an autosomal dominant manner. last updated: 11/17/2014

MalaCards based summary: Hemiplegic Migraine, also known as familial or sporadic hemiplegic migraine, is related to migraine and familial hemiplegic migraine, and has symptoms including hemiplegia/hemiparesis, abnormality of movement and nystagmus. An important gene associated with Hemiplegic Migraine is CACNA1A (calcium channel, voltage-dependent, P/Q type, alpha 1A subunit), and among its related pathways are Interaction between L1 and Ankyrins and Sodium coupled transporters and pumps. The compounds bc-iii and atx-ii have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and cortex, and related mouse phenotypes are normal and respiratory system.

Aliases & Classifications for Hemiplegic Migraine

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Sources:
41NIH Rare Diseases, 60UMLS, 47Orphanet, 43Novoseek, 26ICD10 via Orphanet
See all sources

Hemiplegic Migraine, Aliases & Descriptions:

Name: Hemiplegic Migraine 41 60
Familial or Sporadic Hemiplegic Migraine 41 47
 
Migraine Hemiplegic 43


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

47
familial or sporadic hemiplegic migraine:
Inheritance: Autosomal dominant; Prevalence: 1-5/10000 (Europe); Age of onset: Childhood; Age of death: normal life expectancy


External Ids:

Orphanet47 569
ICD10 via Orphanet26 G43.1

Related Diseases for Hemiplegic Migraine

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Diseases in the Hemiplegic Migraine family:

Migraine, Familial Hemiplegic, 2 Migraine, Familial Hemiplegic, 3
Migraine, Familial Hemiplegic, 1 Familial Hemiplegic Migraine

Diseases related to Hemiplegic Migraine via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 57)
idRelated DiseaseScoreTop Affiliating Genes
1migraine32.7CACNA1A, ATP1A2
2familial hemiplegic migraine31.9SCN1A, DNAH8, CACNA1A, ATP1A2, NOTCH3
3alternating hemiplegia of childhood31.6ATP1A2
4hemiplegia31.4CACNA1A, ATP1A2
5sporadic hemiplegic migraine11.0
6ataxia10.8
7migraine, familial hemiplegic, 110.7
8cerebritis10.7
9migraine, familial hemiplegic, 210.7
10migraine, familial hemiplegic, 310.7
11neuronitis10.7
12episodic ataxia10.6
13cerebellar ataxia10.6
14benign familial infantile epilepsy10.5ATP1A2
15moyamoya disease10.4
16cadasil10.4
17migraine with aura10.4
18weber syndrome10.4
19epilepsy syndrome10.4PRRT2
20dravet syndrome10.4SCN1A
21episodic ataxia, type 210.3
22patent foramen ovale10.3
23dystonia10.3
24meningitis10.3
25retinal degeneration10.3
26retinitis10.3
27spinocerebellar ataxia10.3
28mental retardation10.3
29cluster headache10.3CALCA, CACNA1A
30epilepsy, idiopathic generalized10.3CACNA1A, SCN1A
31cystic fibrosis10.2
32progressive hemifacial atrophy10.2
33status epilepticus10.2
34erdheim-chester disease10.2
35arteriovenous malformation10.2
36aseptic meningitis10.2
37crest syndrome10.2
38intracranial hypertension10.2
39ischemia10.2
40mood disorder10.2
41basilar migraine10.2
42hemicrania continua10.2
43pulmonary arteriovenous malformation10.2
44spastic paraparesis10.2
45cerebral atrophy10.2
46febrile seizures10.2
47headache10.2
48hemiplegia alterans10.2
49spasticity10.2
50tremor10.2

Graphical network of the top 20 diseases related to Hemiplegic Migraine:



Diseases related to hemiplegic migraine

Symptoms for Hemiplegic Migraine

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Symptoms:

 47 (show all 9)
  • movement disorder
  • hemiplegia/diplegia/hemiparesia/limb palsy
  • autosomal dominant inheritance
  • nystagmus
  • ataxia/incoordination/trouble of the equilibrium
  • retinitis pigmentosa/retinal pigmentary changes
  • sensorineural deafness/hearing loss
  • eeg anomalies
  • speech troubles/aphasia/dysphasia/echolalia/mutism/logorrhea/dysprosodia

HPO human phenotypes related to Hemiplegic Migraine:

(show all 8)
id Description Frequency HPO Source Accession
1 hemiplegia/hemiparesis hallmark (90%) HP:0004374
2 abnormality of movement hallmark (90%) HP:0100022
3 nystagmus typical (50%) HP:0000639
4 incoordination typical (50%) HP:0002311
5 sensorineural hearing impairment occasional (7.5%) HP:0000407
6 neurological speech impairment occasional (7.5%) HP:0002167
7 eeg abnormality occasional (7.5%) HP:0002353
8 abnormal retinal pigmentation occasional (7.5%) HP:0007703

Drugs & Therapeutics for Hemiplegic Migraine

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Drug clinical trials:

Search ClinicalTrials for Hemiplegic Migraine

Search NIH Clinical Center for Hemiplegic Migraine

Genetic Tests for Hemiplegic Migraine

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Anatomical Context for Hemiplegic Migraine

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MalaCards organs/tissues related to Hemiplegic Migraine:

31
Brain, Testes, Cortex, Cerebellum, Kidney, Thalamus, Trigeminal ganglion, Tongue

Animal Models for Hemiplegic Migraine or affiliated genes

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MGI Mouse Phenotypes related to Hemiplegic Migraine:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.4ATP1A2, SCN1A, SCN5A, CACNA1A, CALCA, OPRM1
2MP:00053888.2ATP1A2, GNB1, GNAI2, CACNA1A, CALCA, NOTCH3
3MP:00053847.8GNB1, GNAI2, SCN5A, PRKCSH, CACNA1A, OPRM1
4MP:00053867.4NOTCH3, ATP1B2, ATP1A2, GNB1, GNAI2, SCN1A
5MP:00036317.3ATP1B2, ATP1A2, GNB1, GNAI2, SCN1A, SCN5A
6MP:00107687.0GNAI2, GNB1, ATP1A2, ATP1B2, SCN1A, SCN5A

Publications for Hemiplegic Migraine

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Articles related to Hemiplegic Migraine:

(show top 50)    (show all 369)
idTitleAuthorsYear
1
Familial hemiplegic migraine type-1 mutated cav2.1 calcium channels alter inhibitory and excitatory synaptic transmission in the lateral superior olive of mice. (25481823)
2015
2
PRRT2 and hemiplegic migraine: a complex association. (24928127)
2014
3
Hemiplegic migraine: neuroimaging findings during a hemiplegic migraine attack. (24512003)
2014
4
A novel ATP1A2 gene mutation in familial hemiplegic migraine and epilepsy. (23918834)
2014
5
Hemiplegic migraine: An atypical presentation of Moyamoya disease. (25538508)
2014
6
Familial hemiplegic migraine and spreading depression. (25143767)
2014
7
Delayed recovery post anesthesia: an atypical presentation of familial hemiplegic migraine. (24347352)
2013
8
Magnetic Resonance Angiography Evidence of Vasospasm in Children With Suspected Acute Hemiplegic Migraine. (23594822)
2013
9
Hemiplegic migraine with reversible cerebral vasoconstriction caused by ATP1A2 mutations. (23821026)
2013
10
Functional characterization of a novel C-terminal ATP1A2 mutation causing hemiplegic migraine and epilepsy. (23838748)
2013
11
Pulmonary arterial hypertension in familial hemiplegic migraine with ATP1A2 channelopathy. (24136331)
2013
12
Familial hemiplegic migraine with prolonged global aura: follow-up findings of subtraction ictal SPECT co-registered to MRI (SISCOM). (22933508)
2012
13
Stroke and familial hemiplegic migraine. (22608661)
2012
14
Calcitonin gene-related peptide does not cause migraine attacks in patients with familial hemiplegic migraine. (21457239)
2011
15
Increased susceptibility to cortical spreading depression in the mouse model of familial hemiplegic migraine type 2. (21731499)
2011
16
Transient nonverbal learning disorder in a child suffering from Familial Hemiplegic Migraine. (21908445)
2011
17
A novel mutation in CACNA1A associated with hemiplegic migraine, cerebellar dysfunction and late-onset cognitive decline. (21035146)
2011
18
Acute striatal necrosis in hemiplegic migraine with de novo CACNA1A mutation. (22082423)
2011
19
De novo mutations in ATP1A2 and CACNA1A are frequent in early-onset sporadic hemiplegic migraine. (20837964)
2010
20
Insights into migraine mechanisms and CaV2.1 calcium channel function from mouse models of familial hemiplegic migraine. (20194127)
2010
21
Moyamoya disease presented as a case of hemiplegic migraine. (22798438)
2010
22
Neurological picture. Cortical oedema: a link between delusional misidentification syndromes and hemiplegic migraine. (20019221)
2010
23
Coexisting typical migraine in familial hemiplegic migraine. (20157162)
2010
24
Large scale calcium channel gene rearrangements in episodic ataxia and hemiplegic migraine: implications for diagnostic testing. (19586927)
2009
25
Familial hemiplegic migraine is associated with febrile seizures in an FHM2 family with a novel de novo ATP1A2 mutation. (19874388)
2009
26
Genetic analysis of 27 Spanish patients with hemiplegic migraine, basilar-type migraine and childhood periodic syndromes. (18644040)
2008
27
Diverse functional consequences of mutations in the Na+/K+-ATPase alpha2-subunit causing familial hemiplegic migraine type 2. (18728015)
2008
28
Sporadic hemiplegic migraine: report of a case with clinical and radiological features. (18810316)
2008
29
A novel de novo nonsense mutation in ATP1A2 associated with sporadic hemiplegic migraine and epileptic seizures. (18644608)
2008
30
Recurrent ATP1A2 mutations in Portuguese families with familial hemiplegic migraine. (17952365)
2007
31
Sporadic and familial hemiplegic migraine: diagnosis and treatment. (16628531)
2006
32
Alterations in the alpha2 isoform of Na,K-ATPase associated with familial hemiplegic migraine type 2. (16037212)
2005
33
Single-fiber EMG in familial hemiplegic migraine. (15883351)
2005
34
Familial hemiplegic migraine type 1 mutations K1336E, W1684R, and V1696I alter Cav2.1 Ca2+ channel gating: evidence for beta-subunit isoform-specific effects. (15448138)
2004
35
Phenotypes of spinocerebellar ataxia type 6 and familial hemiplegic migraine caused by a unique CACNA1A missense mutation in patients from a large family. (12707077)
2003
36
Serial MRI in a case of familial hemiplegic migraine. (12669159)
2003
37
Magnetic resonance angiogram evidence of vasospasm in familial hemiplegic migraine. (12174974)
2002
38
Idiopathic intracranial hypertension presenting as hemiplegic migraine. (12222727)
2002
39
Mutation analysis of the CACNA1A calcium channel subunit gene in 27 patients with sporadic hemiplegic migraine. (12056940)
2002
40
Multimodal functional imaging of prolonged neurological deficits in a patient suffering from familial hemiplegic migraine. (12384224)
2002
41
Migraine with aura susceptibility locus on chromosome 19p13 is distinct from the familial hemiplegic migraine locus. (11735221)
2001
42
Familial hemiplegic migraine: a ion channel disorder. (11719257)
2001
43
The clinical spectrum of familial hemiplegic migraine associated with mutations in a neuronal calcium channel. (11439943)
2001
44
Motor cortex excitability in patients with migraine with aura and hemiplegic migraine. (10817446)
2000
45
Functional consequences of mutations in the human alpha1A calcium channel subunit linked to familial hemiplegic migraine. (10024348)
1999
46
A new locus for hemiplegic migraine maps to chromosome 1q31. (9371899)
1997
47
Wolff Award 1997. Involvement of a Ca2+ channel gene in familial hemiplegic migraine and migraine with and without aura. Dutch Migraine Genetics Research Group. (9329229)
1997
48
Hemiplegic migraine. (2391303)
1990
49
Unusual angiographic appearance during attack of hemiplegic migraine. (3721866)
1986
50
Hemiplegic migraine. (7288457)
1981

Variations for Hemiplegic Migraine

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Clinvar genetic disease variations for Hemiplegic Migraine:

6 (show all 26)
id Gene Variation Type Significance SNP ID Assembly Location
1NM_006920.4(SCN1A): c.4432C> A (p.Gln1478Lys)single nucleotide variantPathogenicrs121918628GRCh37Chr 2, 166854559: 166854559
2NM_006920.4(SCN1A): c.4462T> C (p.Phe1488Leu)single nucleotide variantPathogenicrs121918632GRCh37Chr 2, 166852609: 166852609
3NM_006920.4(SCN1A): c.4434G> C (p.Gln1478His)single nucleotide variantPathogenicrs121918633GRCh37Chr 2, 166854557: 166854557
4ATP1A2NM_000702.3(ATP1A2): c.2291T> C (p.Leu764Pro)single nucleotide variantPathogenicrs28933398GRCh37Chr 1, 160105635: 160105635
5ATP1A2NM_000702.3(ATP1A2): c.2659T> C (p.Trp887Arg)single nucleotide variantPathogenicrs28933399GRCh37Chr 1, 160106455: 160106455
6ATP1A2NM_000702.3(ATP1A2): c.2192T> C (p.Met731Thr)single nucleotide variantPathogenicrs28933400GRCh37Chr 1, 160105300: 160105300
7ATP1A2NM_000702.3(ATP1A2): c.2066G> A (p.Arg689Gln)single nucleotide variantPathogenicrs28933401GRCh37Chr 1, 160105036: 160105036
8ATP1A2NM_000702.3(ATP1A2): c.901G> A (p.Gly301Arg)single nucleotide variantPathogenicrs121918612GRCh37Chr 1, 160097494: 160097494
9ATP1A2NM_000702.3(ATP1A2): c.1033A> G (p.Thr345Ala)single nucleotide variantPathogenicrs121918613GRCh37Chr 1, 160098457: 160098457
10ATP1A2NM_000702.3(ATP1A2): c.2152G> A (p.Asp718Asn)single nucleotide variantPathogenicrs121918614GRCh37Chr 1, 160105260: 160105260
11ATP1A2NM_000702.3(ATP1A2): c.2936C> T (p.Pro979Leu)single nucleotide variantPathogenicrs121918615GRCh37Chr 1, 160109525: 160109525
12ATP1A2NM_000702.3(ATP1A2): c.857T> C (p.Ile286Thr)single nucleotide variantPathogenicrs121918617GRCh37Chr 1, 160097450: 160097450
13ATP1A2NM_000702.3(ATP1A2): c.1244C> T (p.Thr415Met)single nucleotide variantPathogenicrs121918618GRCh37Chr 1, 160098797: 160098797
14ATP1A2NM_000702.3(ATP1A2): c.193C> T (p.Arg65Trp)single nucleotide variantPathogenicrs121918619GRCh37Chr 1, 160093018: 160093018
15ATP1A2NM_000702.3(ATP1A2): c.1127C> T (p.Thr376Met)single nucleotide variantPathogenicrs121918620GRCh37Chr 1, 160098551: 160098551
16CACNA1ANM_001127221.1(CACNA1A): c.575G> A (p.Arg192Gln)single nucleotide variantPathogenicrs121908211GRCh37Chr 19, 13482558: 13482558
17CACNA1ANM_001127221.1(CACNA1A): c.1997C> T (p.Thr666Met)single nucleotide variantPathogenicrs121908212GRCh37Chr 19, 13414691: 13414691
18CACNA1ANM_001127221.1(CACNA1A): c.2141T> C (p.Val714Ala)single nucleotide variantPathogenicrs121908213GRCh37Chr 19, 13414394: 13414394
19CACNA1ANM_001127221.1(CACNA1A): c.5428A> C (p.Ile1810Leu)single nucleotide variantPathogenicrs121908214GRCh37Chr 19, 13340999: 13340999
20CACNA1ANM_001127221.1(CACNA1A): c.2145C> A (p.Asp715Glu)single nucleotide variantPathogenicrs121908218GRCh37Chr 19, 13414390: 13414390
21CACNA1ANM_001127221.1(CACNA1A): c.4151A> G (p.Tyr1384Cys)single nucleotide variantPathogenicrs121908219GRCh37Chr 19, 13372366: 13372366
22CACNA1ANM_001127221.1(CACNA1A): c.4366G> T (p.Val1456Leu)single nucleotide variantPathogenicrs121908237GRCh37Chr 19, 13370403: 13370403
23CACNA1ANM_001127221.1(CACNA1A): c.653C> T (p.Ser218Leu)single nucleotide variantPathogenicrs121908225GRCh37Chr 19, 13476262: 13476262
24CACNA1ANM_001127221.1(CACNA1A): c.5126T> C (p.Ile1709Thr)single nucleotide variantPathogenicrs121909326GRCh37Chr 19, 13346033: 13346033
25CACNA1ANM_001127221.1(CACNA1A): c.4037G> A (p.Arg1346Gln)single nucleotide variantPathogenicrs121908230GRCh37Chr 19, 13373603: 13373603
26CACNA1ANC_000019.10deletionPathogenicGRCh38Chr 19, 13207898: 13214608

Expression for genes affiliated with Hemiplegic Migraine

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Search GEO for disease gene expression data for Hemiplegic Migraine.

Pathways for genes affiliated with Hemiplegic Migraine

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Pathways related to Hemiplegic Migraine according to GeneCards Suite gene sharing:

(show top 50)    (show all 58)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9SCN1A, SCN5A
2
Show member pathways
9.8ATP1A2, ATP1B2
39.6NOTCH3, ATP1A2, ATP1B2
4
Show member pathways
9.5GNAI2, ATP1A2, ATP1B2
59.3GNG2, GNB1
69.3GNG2, GNB1
79.3GNB1, GNG2
8
Show member pathways
9.3ATP1B2, ATP1A2, SCN1A, SCN5A
99.2SCN5A, GNAI2, ATP1A2, ATP1B2
10
Show member pathways
Cytoskeleton remodeling Reverse signaling by ephrin B58
9.0GNB1, GNG2, GNAI2
11
Show member pathways
Development A1 receptor signaling58
G protein signaling G Protein alpha q signaling cascades58
9.0GNAI2, GNG2, GNB1
12
Show member pathways
Signal transduction cAMP signaling58
9.0GNB1, GNG2, GNAI2
13
Show member pathways
Development Beta adrenergic receptors regulation of ERK58
G protein signaling G Protein alpha s signaling cascades58
G protein signaling G Protein beta gamma signaling cascades58
9.0GNB1, GNG2, GNAI2
14
Show member pathways
9.0GNAI2, GNG2, GNB1
15
Show member pathways
9.0GNAI2, GNG2, GNB1
16
Show member pathways
9.0GNB1, GNG2, GNAI2
17
Show member pathways
Apoptosis and survival BAD phosphorylation58
Development Alpha 2 adrenergic receptor activation of ERK58
Chemotaxis CXCR4 signaling pathway58
9.0GNB1, GNG2, GNAI2
18
Show member pathways
9.0GNB1, GNG2, GNAI2
19
Show member pathways
9.0GNAI2, GNG2, GNB1
20
Show member pathways
G protein signaling G Protein alpha 12 signaling pathway58
9.0GNAI2, GNG2, GNB1
219.0GNAI2, GNG2, GNB1
22
Show member pathways
9.0GNB1, GNG2, GNAI2
23
Show member pathways
9.0GNB1, GNG2, GNAI2
249.0GNAI2, GNG2, GNB1
259.0GNAI2, GNG2, GNB1
269.0GNB1, GNG2, GNAI2
27
Show member pathways
8.7CACNA1A, GNAI2, GNG2, GNB1
28
Show member pathways
8.7GNB1, GNG2, GNAI2, CACNA1A
29
Show member pathways
8.7GNB1, GNG2, GNAI2, CACNA1A
30
Show member pathways
8.7GNB1, GNG2, GNAI2, CACNA1A
31
Show member pathways
8.7GNB1, GNG2, GNAI2, CACNA1A
32
Show member pathways
8.7GNB1, GNG2, GNAI2, CACNA1A
33
Show member pathways
8.7GNB1, GNG2, GNAI2, CACNA1A
34
Show member pathways
8.7GNB1, GNG2, GNAI2, CACNA1A
35
Show member pathways
8.7GNB1, GNG2, GNAI2, CACNA1A
368.7GNB1, GNG2, GNAI2, CACNA1A
37
Show member pathways
8.7GNG2, GNB1, ATP1A2, ATP1B2
38
Show member pathways
8.6GNB1, GNG2, GNAI2, CALCA
398.6GNB1, GNG2, GNAI2, CALCA
40
Show member pathways
8.6GNB1, GNG2, GNAI2, OPRM1
41
Show member pathways
8.5GNAI2, GNG2, GNB1, ATP1B2
42
Show member pathways
8.5NOTCH3, CACNA1A, GNAI2, GNG2, GNB1
43
Show member pathways
8.3GNB1, GNG2, GNAI2, CALCA, OPRM1
44
Show member pathways
8.3GNB1, GNG2, GNAI2, CALCA, OPRM1
45
Show member pathways
8.2GNB1, GNG2, GNAI2, SCN1A, SCN5A, CACNA1A
46
Show member pathways
8.2GNB1, GNG2, GNAI2, SCN1A, SCN5A, CACNA1A
47
Show member pathways
8.2GNB1, GNG2, GNAI2, SCN1A, CACNA1A, OPRM1
48
Show member pathways
8.0GNB1, GNG2, GNAI2, CALCA, OPRM1, NOTCH3
49
Show member pathways
Calcium Regulation in the Cardiac Cell36
8.0CALCA, CACNA1A, GNAI2, GNG2, GNB1, ATP1B2

Compounds for genes affiliated with Hemiplegic Migraine

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Compounds related to Hemiplegic Migraine according to GeneCards Suite gene sharing:

(show all 35)
idCompoundScoreTop Affiliating Genes
1bc-iii2810.3SCN1A, SCN5A
2atx-ii2810.3SCN1A, SCN5A
3aft-ii2810.3SCN1A, SCN5A
4batrachotoxin2810.3SCN1A, SCN5A
5qx 314 chloride5910.2SCN1A, SCN5A
6tetrodotoxin citrate5910.2SCN1A, SCN5A
7phrixotoxin 35910.2SCN1A, SCN5A
8veratridine43 59 2812.2SCN1A, SCN5A
9lithium carbonate5910.2ATP1B2, ATP1A2
10loperamide43 24 1212.1CACNA1A, OPRM1
11tetrodotoxin43 59 2812.0CALCA, SCN5A, SCN1A
12zonisamide43 49 1211.9SCN5A, SCN1A
13heroin43 49 1211.9CALCA, OPRM1
14lidocaine43 28 1211.7OPRM1, SCN5A
15bepridil43 28 1211.7DNAH8, CACNA1A
16ether43 4910.5CALCA, DNAH8
17sodium43 2410.5ATP1B2, ATP1A2, SCN1A, SCN5A, CACNA1A
18verapamil43 28 49 24 1213.4CACNA1A, DNAH8, SCN5A
19digoxin43 59 49 24 1213.4DNAH8, ATP1A2, ATP1B2
20gallein599.4GNAI2, GNG2, GNB1
21clonidine43 49 28 1212.4DNAH8, CALCA, OPRM1
22g-protein antagonist peptide599.4GNAI2, GNG2, GNB1
23suramin hexasodium salt599.4GNB1, GNG2, GNAI2
248-bromo-cgmp, sodium salt599.4GNB1, GNG2, GNAI2
25pertussis toxin599.4GNB1, GNG2, GNAI2
265-hydroxytryptamine439.2OPRM1, CALCA, DNAH8
27potassium43 24 1211.1OPRM1, CACNA1A, SCN5A, SCN1A, ATP1A2, ATP1B2
28Guanosine monophosphate249.1GNAI2, GNG2, GNB1
29acetylcholine43 49 28 24 1213.1OPRM1, CALCA, CACNA1A, DNAH8
30glutamine439.1SCN5A, DNAH8, CACNA1A, OPRM1
31quinidine43 28 49 1212.1DNAH8, SCN5A
32Guanosine diphosphate249.0GNAI2, GNG2, GNB1
33epinephrine43 24 1211.0DNAH8, CALCA, OPRM1
34glutamate438.9ATP1A2, DNAH8, CACNA1A, CALCA, OPRM1
35calcium43 49 24 1211.3ATP1A2, SCN5A, DNAH8, CACNA1A, CALCA, OPRM1

GO Terms for genes affiliated with Hemiplegic Migraine

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Cellular components related to Hemiplegic Migraine according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1sodium:potassium-exchanging ATPase complexGO:00058909.8ATP1A2, ATP1B2
2voltage-gated sodium channel complexGO:00015189.8SCN5A, SCN1A
3T-tubuleGO:00303159.8ATP1A2, SCN5A, SCN1A
4neuronal cell bodyGO:00430259.7CALCA, CACNA1A, SCN1A
5intercalated discGO:00147049.6SCN1A, SCN5A
6heterotrimeric G-protein complexGO:00058349.0GNG2, GNB1, GNAI2
7plasma membraneGO:00058867.1GNB1, ATP1B2, ATP1A2, GNG2, GNAI2, SCN5A

Biological processes related to Hemiplegic Migraine according to GeneCards Suite gene sharing:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1neuromuscular process controlling postureGO:005088410.2PRRT2, SCN1A
2regulation of cardiac muscle cell contractionGO:008600410.2ATP1A2, SCN5A
3negative regulation of cytosolic calcium ion concentrationGO:005148110.2OPRM1, ATP1A2
4membrane depolarizationGO:005189910.2CACNA1A, SCN5A
5gamma-aminobutyric acid signaling pathwayGO:000721410.1GNAI2, CACNA1A
6sodium ion transportGO:000681410.0ATP1A2, SCN5A, SCN1A
7regulation of heart rateGO:000202710.0SCN5A, CALCA
8adult walking behaviorGO:00076289.9CACNA1A, SCN1A
9negative regulation of adenylate cyclase activityGO:00071949.9GNAI2, OPRM1
10G-protein coupled acetylcholine receptor signaling pathwayGO:00072139.9GNAI2, GNB1
11adenylate cyclase-inhibiting G-protein coupled receptor signaling pathwayGO:00071939.8GNAI2, OPRM1
12cellular response to catecholamine stimulusGO:00718709.7GNG2, GNB1
13cellular response to prostaglandin E stimulusGO:00713809.6GNG2, GNB1
14sodium ion transmembrane transportGO:00357259.6SCN5A, SCN1A, ATP1A2, ATP1B2
15positive regulation of cytosolic calcium ion concentrationGO:00072049.4OPRM1, CALCA, CACNA1A, GNB1
16energy reserve metabolic processGO:00061129.4GNG2, CACNA1A, GNB1
17adenylate cyclase-activating dopamine receptor signaling pathwayGO:00071919.3GNB1, GNG2, OPRM1
18cellular response to glucagon stimulusGO:00713779.3GNG2, GNB1
19phospholipase C-activating G-protein coupled receptor signaling pathwayGO:00072009.3GNB1, OPRM1
20platelet activationGO:00301689.0GNB1, GNAI2, GNG2
21synaptic transmissionGO:00072689.0GNAI2, GNG2, GNB1, CACNA1A
22blood coagulationGO:00075968.8GNAI2, ATP1B2, GNB1, GNG2

Molecular functions related to Hemiplegic Migraine according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1sodium:potassium-exchanging ATPase activityGO:00053919.8ATP1A2, ATP1B2
2voltage-gated sodium channel activityGO:00052489.8SCN5A, SCN1A
3voltage-gated calcium channel activityGO:00052459.6OPRM1, CACNA1A
4signal transducer activityGO:00048719.0GNAI2, GNG2, GNB1

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3CDC
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