MCID: HMP006
MIFTS: 49

Hemiplegic Migraine

Categories: Rare diseases, Neuronal diseases, Genetic diseases

Aliases & Classifications for Hemiplegic Migraine

MalaCards integrated aliases for Hemiplegic Migraine:

Name: Hemiplegic Migraine 49 69
Migraine Hemiplegic 51

Classifications:



External Ids:

UMLS 69 C0270862

Summaries for Hemiplegic Migraine

NIH Rare Diseases : 49 Hemiplegic migraine (HM) is a rare type of migraine with aura that occurs with motor weakness during the aura. There are two types of HM which are distinguished based on the family history: familial hemiplegic migraine (FHM, in which at least one other family member has the condition) and sporadic hemiplegic migraine (SHM, in which there is no family history). Signs and symptoms vary but may include visual disturbances, sensory loss, difficulty with speech, weakness on one side of the body, confusion, and impaired consciousness. Severe attacks may occur in both types with prolonged hemiplegia, coma, fever and/or seizures. FHM may be caused by a mutation in any of several genes and is inherited in an autosomal dominant manner. Last updated: 11/17/2014

MalaCards based summary : Hemiplegic Migraine, also known as migraine hemiplegic, is related to sporadic hemiplegic migraine and familial or sporadic hemiplegic migraine. An important gene associated with Hemiplegic Migraine is CACNA1A (Calcium Voltage-Gated Channel Subunit Alpha1 A), and among its related pathways/superpathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and G-Beta Gamma Signaling. The drugs Topiramate and Neuroprotective Agents have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and testes, and related phenotypes are Increased viability with SS1P at EC90 and behavior/neurological

Wikipedia : 72 Hemiplegic migraine or Hemiplegic migraine headache is a rare and serious subtype of classical migraine... more...

Related Diseases for Hemiplegic Migraine

Diseases in the Hemiplegic Migraine family:

Migraine, Familial Hemiplegic, 1 Migraine, Familial Hemiplegic, 2
Migraine, Familial Hemiplegic, 3 Familial Hemiplegic Migraine
Sporadic Hemiplegic Migraine Familial or Sporadic Hemiplegic Migraine

Diseases related to Hemiplegic Migraine via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 79)
# Related Disease Score Top Affiliating Genes
1 sporadic hemiplegic migraine 34.4 ATP1A2 CACNA1A SCN1A
2 familial or sporadic hemiplegic migraine 33.7 ATP1A2 CACNA1A PRRT2 SCN1A
3 familial hemiplegic migraine 32.7 ATP1A2 ATP1A3 CACNA1A CALCA GNAI2 NOTCH3
4 alternating hemiplegia of childhood 32.1 ATP1A2 ATP1A3 CACNA1A CALCA SLC2A1
5 migraine with or without aura 1 31.1 ATP1A2 ATP1A3 CACNA1A CALCA MGR5 MGR6
6 episodic ataxia 30.8 ATP1A2 CACNA1A PRRT2
7 aceruloplasminemia 30.3 ATP1A3 CACNA1A SLC2A1
8 torticollis 30.0 CACNA1A PRRT2
9 migraine with aura 30.0 ATP1A2 CACNA1A NOTCH3 PRRT2 SCN1A
10 headache 29.9 ATP1A2 CACNA1A CALCA SCN1A
11 hemiplegia 29.9 ATP1A2 ATP1A3 CACNA1A CALCA SCN1A SLC2A1
12 migraine, familial hemiplegic, 1 12.2
13 migraine, familial hemiplegic, 2 12.2
14 migraine, familial hemiplegic, 3 12.2
15 alternating hemiplegia of childhood 1 11.2
16 convulsions, familial infantile, with paroxysmal choreoathetosis 11.1
17 alternating hemiplegia of childhood 2 11.1
18 phosphoglycerate kinase deficiency 11.1
19 hemiplegia alterans 11.1
20 ataxia and polyneuropathy, adult-onset 10.5
21 cerebritis 10.4
22 neuronitis 10.4
23 epilepsy 10.3
24 migraine without aura 10.3 ATP1A2 CACNA1A SCN1A
25 ataxia-oculomotor apraxia 3 10.3
26 encephalopathy 10.3
27 glut1 deficiency syndrome 2 10.2 PRRT2 SLC2A1
28 myoclonic astatic epilepsy 10.2 SCN1A SLC2A1
29 hydrops, lactic acidosis, and sideroblastic anemia 10.2
30 paroxysmal choreoathetosis 10.2 PRRT2 SLC2A1
31 cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1 10.1
32 dystonia, dopa-responsive 10.1 ATP1A3 PRRT2 SLC2A1
33 spinocerebellar ataxia 6 10.1
34 sturge-weber syndrome 10.1
35 moyamoya disease 1 10.1
36 autosomal dominant cerebellar ataxia 10.1
37 weber syndrome 10.1
38 early onset absence epilepsy 10.1 PRRT2 SLC2A1
39 cluster headache 10.0 CACNA1A CALCA
40 episodic ataxia, type 2 10.0
41 allergic hypersensitivity disease 10.0
42 patent foramen ovale 10.0
43 retinitis 10.0
44 dystonia 10.0
45 retinal degeneration 10.0
46 meningitis 10.0
47 epilepsy, idiopathic generalized 9.8 CACNA1A OPRM1 SCN1A SLC2A1
48 fibrosis of extraocular muscles, congenital, 1 9.8
49 hemifacial atrophy, progressive 9.8
50 pulmonary hypertension, primary, 1 9.8

Graphical network of the top 20 diseases related to Hemiplegic Migraine:



Diseases related to Hemiplegic Migraine

Symptoms & Phenotypes for Hemiplegic Migraine

GenomeRNAi Phenotypes related to Hemiplegic Migraine according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with SS1P at EC90 GR00376-A-1 8.8 ATP1A3 GNAI2 GNB1

MGI Mouse Phenotypes related to Hemiplegic Migraine:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.1 GNAI2 SLC2A1 GNB1 ATP1A2 NOTCH3 ATP1A3
2 mortality/aging MP:0010768 10.07 GNAI2 SLC2A1 GNB1 ATP1A2 NOTCH3 ATP1A3
3 nervous system MP:0003631 9.93 GNAI2 SLC2A1 GNB1 ATP1A2 NOTCH3 ATP1A3
4 normal MP:0002873 9.56 GNAI2 ATP1A2 NOTCH3 OPRM1 ATP1B1 SCN1A
5 respiratory system MP:0005388 9.17 GNAI2 GNB1 ATP1A2 NOTCH3 ATP1A3 ATP1B1

Drugs & Therapeutics for Hemiplegic Migraine

Drugs for Hemiplegic Migraine (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Topiramate Approved Phase 2, Phase 3 97240-79-4 5284627
2 Neuroprotective Agents Phase 2, Phase 3
3 Anticonvulsants Phase 2, Phase 3
4 Protective Agents Phase 2, Phase 3
5 Anti-Obesity Agents Phase 2, Phase 3
6
Nitroglycerin Approved, Investigational 55-63-0 4510
7
Salmon Calcitonin Approved, Investigational 47931-85-1 16129616
8
Pancrelipase Approved, Investigational 53608-75-6
9 Calcitonin Gene-Related Peptide
10 calcitonin
11 Vasodilator Agents
12 Bone Density Conservation Agents
13 pancreatin

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Dose Comparison Study of Topiramate in Pediatric Subjects With Basilar/Hemiplegic Migraine Completed NCT00131443 Phase 2, Phase 3 Topiramate
2 A Study of Topiramate in Pediatric Subjects With Basilar/Hemiplegic Migraine Completed NCT00158002 Phase 2 Topiramate
3 Glyceryl-Trinitrate-Induced Headache in Patients With Familial Hemiplegic Migraine Completed NCT00541736 Nitroglycerine
4 Calcitonin Gene Related Peptide-Induced Headache in Patients With Familial Hemiplegic Migraine Type 1 and 2. Completed NCT00358839 CGRP
5 Glyceryl-Trinitrate-Induced Headache in Patients With Familial Hemiplegic Migraine Type 1 and 2 Completed NCT00257985 GTN
6 Calcitonin Gene-related Peptide in Familial Hemiplegic Migraine (FHM) and Migraine With Aura (MA) Completed NCT00687947 CGRP
7 Genetic Analysis of Children With Cyclic Vomiting Syndrome (CVS) and Migraines Recruiting NCT00727974
8 Pilot Study of Acute Stroke Using the Brainpulse™ Not yet recruiting NCT03235271

Search NIH Clinical Center for Hemiplegic Migraine

Genetic Tests for Hemiplegic Migraine

Anatomical Context for Hemiplegic Migraine

MalaCards organs/tissues related to Hemiplegic Migraine:

38
Brain, Bone, Testes, Trigeminal Ganglion, Tongue, Thalamus, Kidney

Publications for Hemiplegic Migraine

Articles related to Hemiplegic Migraine:

(show top 50) (show all 419)
# Title Authors Year
1
Clinical spectrum of hemiplegic migraine and chances of finding a pathogenic mutation. ( 29343472 )
2018
2
Ocular Dipping in a Patient With Hemiplegic Migraine. ( 29384561 )
2018
3
First Episode of Hemiplegic Migraine. ( 28601240 )
2017
4
Identification of the first in Poland CACNA1A gene mutation in familial hemiplegic migraine. Case report. ( 28169007 )
2017
5
Cerebellar Atrophy and Changes in Cytokines Associated with the CACNA1A R583Q Mutation in a Russian Familial Hemiplegic Migraine Type 1 Family. ( 28900389 )
2017
6
Enhanced susceptibility to cortical spreading depression in two types of Na<sup>+</sup>,K<sup>+</sup>-ATPase I+2 subunit-deficient mice as a model of familial hemiplegic migraine 2. ( 29041816 )
2017
7
De novo exonic duplication of ATP1A2 in Italian patient with hemiplegic migraine: a case report. ( 28593511 )
2017
8
Stroke-like attack: first episode of sporadic hemiplegic migraine. ( 28527090 )
2017
9
Ten years of follow-up in a large family with familial hemiplegic migraine type 1: Clinical course and implications for treatment. ( 28856914 )
2017
10
Two novel families with hemiplegic migraine caused by recurrent SCN1A mutation p.F1499L. ( 29145747 )
2017
11
Epilepsy in hemiplegic migraine: Genetic mutations and clinical implications. ( 28058944 )
2017
12
Reversible cortical thickening in hemiplegic migraine. ( 28120619 )
2017
13
Mild Traumatic Brain Injury in a High School Football Player with Familial Hemiplegic Migraine: A Case Report. ( 28918117 )
2017
14
Familial Hemiplegic Migraine With Asymmetric Encephalopathy Secondary to ATP1A2 Mutation: A Case Series. ( 28445178 )
2017
15
The I+2I^2 isoform combination dominates the astrocytic Na(+) /K(+) -ATPase activity and is rendered nonfunctional by the I+2.G301R familial hemiplegic migraine type 2-associated mutation. ( 28787093 )
2017
16
Hyperpolarization-activated current Ih in mouse trigeminal sensory neurons in a transgenic mouse model of familial hemiplegic migraine type-1. ( 28363781 )
2017
17
Brain atrophy following hemiplegic migraine attacks. ( 28750589 )
2017
18
Sulcal hyperintensity mimicking subarachnoid hemorrhage in the context of hemiplegic migraine. ( 29236896 )
2017
19
Acute Intravenous Calcium Antagonist for Suspected Hemiplegic Migraine - A Case Story. ( 28559833 )
2017
20
The genetic relationship between epilepsy and hemiplegic migraine. ( 28479855 )
2017
21
Activity-dependent calcium, oxygen, and vascular responses in a mouse model of familial hemiplegic migraine type 1. ( 27314908 )
2016
22
Loss of inhibition by brain natriuretic peptide over P2X3 receptors contributes to enhanced spike firing of trigeminal ganglion neurons in a mouse model of familial hemiplegic migraine type-1. ( 27346147 )
2016
23
Hemiplegic migraine and late-onset photosensitive epileptic seizures. ( 27406575 )
2016
24
A novel SCN1A mutation identified in a Chinese family with familial hemiplegic migraine: A case report. ( 27919014 )
2016
25
Recurrent coma and fever in familial hemiplegic migraine type 2. A prospective 15-year follow-up of a large family with a novel ATP1A2 mutation. ( 27226003 )
2016
26
Hemiplegic Migraine Presenting with Prolonged Somnolence: A Case Report. ( 27790126 )
2016
27
Intermittent Theta Slowings in Contralateral Side of Weakness after Sleep Deprivation on Spot EEG in Sporadic Hemiplegic Migraine. ( 28101483 )
2016
28
Prevalence of lifetime depression in a large hemiplegic migraine cohort. ( 27807184 )
2016
29
Defective glutamate and K+ clearance by cortical astrocytes in familial hemiplegic migraine type 2. ( 27354390 )
2016
30
A retrospective analysis of triptan and dhe use for basilar and hemiplegic migraine. ( 27062528 )
2016
31
Postoperative Hemiplegic Migraine After a Laparoscopic Cholecystectomy: A Case Report. ( 28045726 )
2016
32
Glutamate-system defects behind psychiatric manifestations in a familial hemiplegic migraine type 2 disease-mutation mouse model. ( 26911348 )
2016
33
Early-onset familial hemiplegic migraine due to a novel SCN1A mutation. ( 26763045 )
2016
34
Clinical and electroencephalographic abnormalities during the full duration of a sporadic hemiplegic migraine attack. ( 27155821 )
2016
35
Inefficient constitutive inhibition of P2X3 receptors by brain natriuretic peptide system contributes to sensitization of trigeminal sensory neurons in a genetic mouse model of familial hemiplegic migraine. ( 27175010 )
2016
36
Familial Hemiplegic Migraine with Severe Attacks: A New Report with ATP1A2 Mutation. ( 27818813 )
2016
37
Time course of downbeat positioning nystagmus in familial hemiplegic migraine type 1 treated with acetazolamide. ( 27538634 )
2016
38
A case report of sporadic hemiplegic migraine associated cerebral hypoperfusion: comparison of arterial spin labeling and dynamic susceptibility contrast perfusion MR imaging. ( 26250760 )
2015
39
Sporadic hemiplegic migraine and giant tumefactive perivascular space: Is there an association? ( 26696413 )
2015
40
Concordant Occipital and Supraorbital Neurostimulation Therapy for Hemiplegic Migraine; Initial Experience; A Case Series. ( 25688595 )
2015
41
P068. A suggestive case of hemiplegic migraine: a diagnostic challenge. ( 28132306 )
2015
42
Stress hormone corticosterone enhances susceptibility to cortical spreading depression in familial hemiplegic migraine type 1 mutant mice. ( 25447936 )
2015
43
P016. Congenital ataxia, hemiplegic migraine due to a novel mutation of CACNA1A: a case report. ( 28132242 )
2015
44
Novel frameshift mutation in the CACNA1A gene causing a mixed phenotype of episodic ataxia and familiar hemiplegic migraine. ( 25468264 )
2015
45
Cortical spreading depression and familial hemiplegic migraine 2015. ( 28132368 )
2015
46
Plasma metabolic profiling after cortical spreading depression in a transgenic mouse model of hemiplegic migraine by capillary electrophoresis - mass spectrometry. ( 25856790 )
2015
47
Abnormal synaptic Ca(2+) homeostasis and morphology in cortical neurons of familial hemiplegic migraine type 1 mutant mice. ( 26032020 )
2015
48
Familial hemiplegic migraine type-1 mutated cav2.1 calcium channels alter inhibitory and excitatory synaptic transmission in the lateral superior olive of mice. ( 25481823 )
2015
49
CAPOS syndrome and hemiplegic migraine in a novel pedigree with the specific ATP1A3 mutation. ( 26453127 )
2015
50
Biphasic neurovascular changes in prolonged migraine aura in familial hemiplegic migraine type 2. ( 25411546 )
2015

Variations for Hemiplegic Migraine

Expression for Hemiplegic Migraine

Search GEO for disease gene expression data for Hemiplegic Migraine.

Pathways for Hemiplegic Migraine

Pathways related to Hemiplegic Migraine according to GeneCards Suite gene sharing:

(show all 40)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.34 ATP1A2 ATP1A3 ATP1B1 ATP1B2 GNB1 GNG2
2
Show member pathways
12.98 CACNA1A GNAI2 GNB1 GNG2 SCN1A SCN5A
3 12.79 GNAI2 GNB1 GNG2 NOTCH3 SLC2A1
4
Show member pathways
12.77 ATP1A2 ATP1A3 ATP1B1 ATP1B2 SCN1A SCN5A
5
Show member pathways
12.72 CACNA1A GNAI2 GNB1 GNG2 SCN1A
6
Show member pathways
12.68 ATP1A2 ATP1A3 ATP1B1 ATP1B2 GNAI2
7
Show member pathways
12.59 ATP1A2 ATP1A3 ATP1B1 ATP1B2 GNAI2 SCN5A
8
Show member pathways
12.56 ATP1A2 ATP1A3 ATP1B1 ATP1B2 SCN1A SCN5A
9 12.55 CALCA NOTCH3 OPRM1 SCN1A SCN5A
10
Show member pathways
12.52 GNAI2 GNB1 GNG2 NOTCH3 OPRM1
11
Show member pathways
12.51 CACNA1A GNAI2 GNB1 GNG2 OPRM1
12
Show member pathways
12.48 GNAI2 GNB1 GNG2 OPRM1
13
Show member pathways
12.47 ATP1A2 ATP1A3 ATP1B1 ATP1B2
14 12.32 CACNA1A GNAI2 GNB1 GNG2
15
Show member pathways
12.3 CACNA1A GNAI2 GNB1 GNG2 SLC2A1
16
Show member pathways
12.21 ATP1A2 ATP1A3 ATP1B1 ATP1B2 GNAI2
17
Show member pathways
12.16 GNAI2 GNB1 GNG2 SLC2A1
18
Show member pathways
12.09 ATP1A2 ATP1A3 ATP1B1 ATP1B2 GNAI2
19 12.08 CALCA GNAI2 GNB1 GNG2
20 12.03 GNAI2 GNB1 GNG2 NOTCH3
21
Show member pathways
11.99 ATP1B1 ATP1B2 CACNA1A CALCA GNAI2 GNB1
22
Show member pathways
11.97 ATP1A2 ATP1A3 ATP1B1 ATP1B2
23 11.91 CACNA1A GNAI2 GNB1 GNG2
24 11.83 ATP1A2 ATP1A3 ATP1B1 ATP1B2
25
Show member pathways
11.81 GNAI2 GNB1 GNG2
26 11.72 ATP1A2 ATP1A3 ATP1B1 ATP1B2
27 11.66 GNAI2 GNB1 GNG2
28 11.64 GNAI2 GNB1 GNG2
29 11.47 ATP1A2 ATP1A3 ATP1B1 ATP1B2
30 11.45 GNAI2 GNB1 GNG2
31 11.41 ATP1A2 ATP1A3 ATP1B1 ATP1B2
32 11.4 ATP1A2 ATP1A3 ATP1B1 ATP1B2 SLC2A1
33 11.35 CACNA1A GNAI2 GNB1 GNG2
34 11.35 ATP1A2 ATP1A3 ATP1B1 ATP1B2
35 11.29 GNAI2 GNB1 GNG2
36 11.19 ATP1A2 ATP1A3 ATP1B1 ATP1B2
37 11.16 ATP1A2 ATP1A3 ATP1B1 ATP1B2 NOTCH3 SLC2A1
38 10.94 GNB1 GNG2
39 10.92 ATP1A2 ATP1A3 ATP1B1 ATP1B2
40 10.48 GNB1 GNG2

GO Terms for Hemiplegic Migraine

Cellular components related to Hemiplegic Migraine according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 axon GO:0030424 9.8 ATP1A3 CALCA OPRM1 SCN1A
2 myelin sheath GO:0043209 9.76 ATP1A2 ATP1A3 ATP1B1 GNB1
3 Z disc GO:0030018 9.69 SCN1A SCN5A SLC2A1
4 extracellular vesicle GO:1903561 9.65 ATP1A2 ATP1A3 ATP1B1 GNAI2 GNB1
5 caveola GO:0005901 9.62 ATP1A2 ATP1B1 SCN5A SLC2A1
6 T-tubule GO:0030315 9.61 ATP1A2 SCN1A SCN5A
7 heterotrimeric G-protein complex GO:0005834 9.58 GNAI2 GNB1 GNG2
8 intercalated disc GO:0014704 9.55 ATP1A2 ATP1B1 SCN1A SCN5A SLC2A1
9 voltage-gated sodium channel complex GO:0001518 9.48 SCN1A SCN5A
10 sodium:potassium-exchanging ATPase complex GO:0005890 9.26 ATP1A2 ATP1A3 ATP1B1 ATP1B2
11 sarcolemma GO:0042383 9.1 ATP1A2 ATP1A3 ATP1B1 OPRM1 SCN5A SLC2A1
12 membrane GO:0016020 10.37 ATP1A2 ATP1A3 ATP1B1 ATP1B2 CACNA1A GNAI2
13 plasma membrane GO:0005886 10.21 ATP1A2 ATP1A3 ATP1B1 ATP1B2 CACNA1A GNAI2

Biological processes related to Hemiplegic Migraine according to GeneCards Suite gene sharing:

(show all 33)
# Name GO ID Score Top Affiliating Genes
1 ion transmembrane transport GO:0034220 9.95 ATP1A2 ATP1A3 ATP1B1 ATP1B2 CACNA1A SCN1A
2 protein folding GO:0006457 9.89 GNAI2 GNB1 GNG2 PRKCSH
3 potassium ion transport GO:0006813 9.87 ATP1A2 ATP1A3 ATP1B1 ATP1B2
4 sodium ion transport GO:0006814 9.85 ATP1A2 ATP1A3 ATP1B1 ATP1B2 SCN1A SCN5A
5 regulation of cardiac conduction GO:1903779 9.83 ATP1A2 ATP1A3 ATP1B1 ATP1B2
6 cardiac muscle contraction GO:0060048 9.78 ATP1A2 ATP1A3 ATP1B1 SCN5A
7 potassium ion import GO:0010107 9.73 ATP1A2 ATP1A3 ATP1B1 ATP1B2
8 membrane depolarization during action potential GO:0086010 9.72 CACNA1A SCN1A SCN5A
9 membrane repolarization GO:0086009 9.69 ATP1A2 ATP1B1 ATP1B2
10 adenylate cyclase-activating dopamine receptor signaling pathway GO:0007191 9.67 GNB1 GNG2 OPRM1
11 response to pain GO:0048265 9.66 CACNA1A CALCA
12 cellular response to prostaglandin E stimulus GO:0071380 9.65 GNB1 GNG2
13 cardiac muscle cell action potential involved in contraction GO:0086002 9.65 SCN1A SCN5A
14 G-protein coupled acetylcholine receptor signaling pathway GO:0007213 9.65 GNAI2 GNB1
15 cellular response to steroid hormone stimulus GO:0071383 9.64 ATP1A2 ATP1A3
16 neuromuscular process controlling posture GO:0050884 9.64 PRRT2 SCN1A
17 regulation of cardiac muscle cell contraction GO:0086004 9.63 ATP1A2 SCN5A
18 relaxation of cardiac muscle GO:0055119 9.63 ATP1A2 ATP1B1
19 ATP hydrolysis coupled transmembrane transport GO:0090662 9.63 ATP1A3 ATP1B1 ATP1B2
20 membrane depolarization during cardiac muscle cell action potential GO:0086012 9.62 ATP1A2 SCN5A
21 cell communication by electrical coupling involved in cardiac conduction GO:0086064 9.62 ATP1A2 ATP1A3 ATP1B1 ATP1B2
22 potassium ion import across plasma membrane GO:1990573 9.61 ATP1A2 ATP1B1
23 cellular response to catecholamine stimulus GO:0071870 9.61 GNB1 GNG2
24 positive regulation of potassium ion transmembrane transporter activity GO:1901018 9.6 ATP1B1 ATP1B2
25 response to glycoside GO:1903416 9.58 ATP1A2 ATP1A3
26 positive regulation of sodium ion export across plasma membrane GO:1903278 9.58 ATP1B1 ATP1B2
27 positive regulation of potassium ion import GO:1903288 9.56 ATP1B1 ATP1B2
28 cellular sodium ion homeostasis GO:0006883 9.56 ATP1A2 ATP1A3 ATP1B1 ATP1B2
29 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.46 ATP1A2 ATP1A3 ATP1B1 ATP1B2
30 cellular potassium ion homeostasis GO:0030007 9.26 ATP1A2 ATP1A3 ATP1B1 ATP1B2
31 sodium ion export across plasma membrane GO:0036376 8.92 ATP1A2 ATP1A3 ATP1B1 ATP1B2
32 transport GO:0006810 10.22 ATP1A2 ATP1A3 ATP1B1 ATP1B2 CACNA1A SCN1A
33 ion transport GO:0006811 10.08 ATP1A2 ATP1A3 ATP1B1 ATP1B2 CACNA1A SCN1A

Molecular functions related to Hemiplegic Migraine according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 voltage-gated ion channel activity GO:0005244 9.61 CACNA1A SCN1A SCN5A
2 ion channel activity GO:0005216 9.54 CACNA1A SCN1A SCN5A
3 ATPase activator activity GO:0001671 9.4 ATP1B1 ATP1B2
4 potassium ion binding GO:0030955 9.32 ATP1A2 ATP1B1
5 sodium ion binding GO:0031402 9.26 ATP1A2 ATP1B1
6 G-protein beta-subunit binding GO:0031681 9.16 GNG2 OPRM1
7 steroid hormone binding GO:1990239 8.96 ATP1A2 ATP1A3
8 sodium:potassium-exchanging ATPase activity GO:0005391 8.92 ATP1A2 ATP1A3 ATP1B1 ATP1B2

Sources for Hemiplegic Migraine

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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