MCID: HMP006
MIFTS: 51

Hemiplegic Migraine malady

Genetic diseases, Rare diseases, Neuronal diseases categories

Summaries for Hemiplegic Migraine

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44NIH Rare Diseases, 66Wikipedia, 34MalaCards
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NIH Rare Diseases:44 Hemiplegic migraine refers to migraineĀ with aura accompanied with motor weakness. signs and symptoms vary but may includeĀ visual disturbance, sensory loss, difficulty with speech,Ā weakness on one side of the body, confusion, and impaired consciousness. frequency of hemiplegic migraine can vary considerably. it can take time for symptoms to resolve, but permanent motor, sensory, language, or visual symptoms are extremely rare. it can occur as a sporadic or genetic disorder. when inherited, it is passed through families in an autosomal dominantĀ fashion. last updated: 8/26/2013

MalaCards: Hemiplegic Migraine, also known as migraine hemiplegic, is related to migraine and familial hemiplegic migraine. An important gene associated with Hemiplegic Migraine is CACNA1A (calcium channel, voltage-dependent, P/Q type, alpha 1A subunit), and among its related pathways are Interaction between L1 and Ankyrins and Sodium coupled transporters and pumps. The compounds bc-iii and atx-ii have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and cortex, and related mouse phenotypes are normal and respiratory system.

Wikipedia:66 Familial hemiplegic migraine (FHM) is an autosomal dominant classical migraine subtype that typically... more...

Aliases & Classifications for Hemiplegic Migraine

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Sources:
44NIH Rare Diseases, 63UMLS, 46Novoseek
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

hemiplegic migraine 44 63
migraine hemiplegic 46


Related Diseases for Hemiplegic Migraine

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the Familial Hemiplegic Migraine Type 1 family:

Familial Hemiplegic Migraine Familial Hemiplegic Migraine Type 2
Familial Hemiplegic Migraine Type 3 hemiplegic migraine

Diseases related to Hemiplegic Migraine via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 62)
idRelated DiseaseScoreTop Affiliating Genes
1migraine32.1ATP1A2, SCN1A, PRRT2, CACNA1A, CALCA, NOTCH3
2familial hemiplegic migraine31.9ATP1A2, SCN1A, DNAH8, CACNA1A, NOTCH3
3alternating hemiplegia of childhood31.0ATP1A2
4hemiplegia30.9CACNA1A, ATP1A2
5sporadic hemiplegic migraine11.0
6familial hemiplegic migraine type 110.9
7familial hemiplegic migraine type 210.8
8ataxia10.7
9cerebritis10.7
10familial hemiplegic migraine type 310.7
11neuronitis10.6
12episodic ataxia10.6
13cerebellar ataxia10.5
14cadasil10.4
15migraine with aura10.4
16sturge-weber syndrome10.4
17weber syndrome10.4
18patent foramen ovale10.3
19moyamoya disease10.3
20dystonia10.3
21hypertension10.3
22meningitis10.3
23retinal degeneration10.3
24retinitis10.3
25episodic ataxia type 210.3
26mental retardation10.3
27paroxysmal dyskinesia10.3
28status epilepticus10.1
29cystic fibrosis10.1
30mitral valve prolapse10.1
31erdheim-chester disease10.1
32arteriovenous malformation10.1
33aseptic meningitis10.1
34intracranial hypertension10.1
35ischemia10.1
36mood disorder10.1
37spinocerebellar ataxia10.1
38spinocerebellar ataxia type 610.1
39basilar migraine10.1
40hemicrania continua10.1
41progressive hemifacial atrophy10.1
42pulmonary arteriovenous malformation10.1
43spastic paraparesis10.1
44cerebral atrophy10.1
45febrile seizures10.1
46headache10.1
47hemiplegia alterans10.1
48spasticity10.1
49tremor10.1
50blindness10.1

Graphical network of the top 20 diseases related to Hemiplegic Migraine:



Diseases related to hemiplegic migraine

Symptoms for Hemiplegic Migraine

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Drugs & Therapeutics for Hemiplegic Migraine

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Hemiplegic Migraine

Drug clinical trials:

Search ClinicalTrials for Hemiplegic Migraine

Search NIH Clinical Center for Hemiplegic Migraine

Search CenterWatch for Hemiplegic Migraine

Genetic Tests for Hemiplegic Migraine

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Anatomical Context for Hemiplegic Migraine

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34MalaCards
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MalaCards organs/tissues related to Hemiplegic Migraine:

34
Brain, Testes, Cortex, Cerebellum, Kidney, Thalamus, Trigeminal ganglion, Tongue

Animal Models for Hemiplegic Migraine or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Hemiplegic Migraine:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.5ATP1A2, SCN1A, SCN5A, CACNA1A, CALCA, OPRM1
2MP:00053888.3ATP1A2, GNB1, GNAI2, CACNA1A, CALCA, NOTCH3
3MP:00053847.8GNB1, GNAI2, SCN5A, PRKCSH, CACNA1A, OPRM1
4MP:00053867.4NOTCH3, ATP1B2, ATP1A2, GNB1, GNAI2, SCN1A
5MP:00036317.3ATP1B2, ATP1A2, GNB1, GNAI2, SCN1A, SCN5A
6MP:00107687.0GNAI2, GNB1, ATP1A2, ATP1B2, SCN1A, SCN5A

Publications for Hemiplegic Migraine

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53PubMed
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Articles related to Hemiplegic Migraine:

(show top 50)    (show all 342)
idTitleAuthorsYear
1
A novel ATP1A2 gene mutation in familial hemiplegic migraine and epilepsy. (23918834)
2014
2
Delayed recovery post anesthesia: an atypical presentation of familial hemiplegic migraine. (24347352)
2013
3
Magnetic Resonance Angiography Evidence of Vasospasm in Children With Suspected Acute Hemiplegic Migraine. (23594822)
2013
4
Hemiplegic migraine with reversible cerebral vasoconstriction caused by ATP1A2 mutations. (23821026)
2013
5
Functional characterization of a novel C-terminal ATP1A2 mutation causing hemiplegic migraine and epilepsy. (23838748)
2013
6
Pulmonary arterial hypertension in familial hemiplegic migraine with ATP1A2 channelopathy. (24136331)
2013
7
Transient unilateral spatial neglect during aura in a woman with sporadic hemiplegic migraine. (23674829)
2013
8
Familial hemiplegic migraine with prolonged global aura: follow-up findings of subtraction ictal SPECT co-registered to MRI (SISCOM). (22933508)
2012
9
Stroke and familial hemiplegic migraine. (22608661)
2012
10
Calcitonin gene-related peptide does not cause migraine attacks in patients with familial hemiplegic migraine. (21457239)
2011
11
Increased susceptibility to cortical spreading depression in the mouse model of familial hemiplegic migraine type 2. (21731499)
2011
12
Transient nonverbal learning disorder in a child suffering from Familial Hemiplegic Migraine. (21908445)
2011
13
A novel mutation in CACNA1A associated with hemiplegic migraine, cerebellar dysfunction and late-onset cognitive decline. (21035146)
2011
14
Acute striatal necrosis in hemiplegic migraine with de novo CACNA1A mutation. (22082423)
2011
15
Enhanced subcortical spreading depression in familial hemiplegic migraine type 1 mutant mice. (21490217)
2011
16
De novo mutations in ATP1A2 and CACNA1A are frequent in early-onset sporadic hemiplegic migraine. (20837964)
2010
17
Insights into migraine mechanisms and CaV2.1 calcium channel function from mouse models of familial hemiplegic migraine. (20194127)
2010
18
Moyamoya disease presented as a case of hemiplegic migraine. (22798438)
2010
19
Neurological picture. Cortical oedema: a link between delusional misidentification syndromes and hemiplegic migraine. (20019221)
2010
20
Coexisting typical migraine in familial hemiplegic migraine. (20157162)
2010
21
Link between confusional migraine, hemiplegic migraine and episodic ataxia type 2: hypothesis, family genealogy, gene typing and classification. (19624685)
2010
22
Large scale calcium channel gene rearrangements in episodic ataxia and hemiplegic migraine: implications for diagnostic testing. (19586927)
2009
23
Familial hemiplegic migraine is associated with febrile seizures in an FHM2 family with a novel de novo ATP1A2 mutation. (19874388)
2009
24
Genetic analysis of 27 Spanish patients with hemiplegic migraine, basilar-type migraine and childhood periodic syndromes. (18644040)
2008
25
Diverse functional consequences of mutations in the Na+/K+-ATPase alpha2-subunit causing familial hemiplegic migraine type 2. (18728015)
2008
26
Sporadic hemiplegic migraine: report of a case with clinical and radiological features. (18810316)
2008
27
A novel de novo nonsense mutation in ATP1A2 associated with sporadic hemiplegic migraine and epileptic seizures. (18644608)
2008
28
Recurrent ATP1A2 mutations in Portuguese families with familial hemiplegic migraine. (17952365)
2007
29
Sporadic and familial hemiplegic migraine: diagnosis and treatment. (16628531)
2006
30
Alterations in the alpha2 isoform of Na,K-ATPase associated with familial hemiplegic migraine type 2. (16037212)
2005
31
Single-fiber EMG in familial hemiplegic migraine. (15883351)
2005
32
Familial hemiplegic migraine type 1 mutations K1336E, W1684R, and V1696I alter Cav2.1 Ca2+ channel gating: evidence for beta-subunit isoform-specific effects. (15448138)
2004
33
Single-fiber EMG in familial hemiplegic migraine. (15557518)
2004
34
Phenotypes of spinocerebellar ataxia type 6 and familial hemiplegic migraine caused by a unique CACNA1A missense mutation in patients from a large family. (12707077)
2003
35
Serial MRI in a case of familial hemiplegic migraine. (12669159)
2003
36
Treatment of sporadic hemiplegic migraine with calcium-channel blocker verapamil. (12525732)
2003
37
Magnetic resonance angiogram evidence of vasospasm in familial hemiplegic migraine. (12174974)
2002
38
Idiopathic intracranial hypertension presenting as hemiplegic migraine. (12222727)
2002
39
Mutation analysis of the CACNA1A calcium channel subunit gene in 27 patients with sporadic hemiplegic migraine. (12056940)
2002
40
Multimodal functional imaging of prolonged neurological deficits in a patient suffering from familial hemiplegic migraine. (12384224)
2002
41
Migraine with aura susceptibility locus on chromosome 19p13 is distinct from the familial hemiplegic migraine locus. (11735221)
2001
42
Familial hemiplegic migraine: a ion channel disorder. (11719257)
2001
43
The clinical spectrum of familial hemiplegic migraine associated with mutations in a neuronal calcium channel. (11439943)
2001
44
Motor cortex excitability in patients with migraine with aura and hemiplegic migraine. (10817446)
2000
45
Functional consequences of mutations in the human alpha1A calcium channel subunit linked to familial hemiplegic migraine. (10024348)
1999
46
A new locus for hemiplegic migraine maps to chromosome 1q31. (9371899)
1997
47
Wolff Award 1997. Involvement of a Ca2+ channel gene in familial hemiplegic migraine and migraine with and without aura. Dutch Migraine Genetics Research Group. (9329229)
1997
48
Hemiplegic migraine. (2391303)
1990
49
Unusual angiographic appearance during attack of hemiplegic migraine. (3721866)
1986
50
Hemiplegic migraine. (7288457)
1981

Variations for Hemiplegic Migraine

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Expression for genes affiliated with Hemiplegic Migraine

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hemiplegic Migraine

Search GEO for disease gene expression data for Hemiplegic Migraine.

Pathways for genes affiliated with Hemiplegic Migraine

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Sources:
51PathCards, 56Reactome, 13EMD Millipore, 31KEGG, 39NCBI BioSystems Database, 54QIAGEN, 61Thomson Reuters, 52PharmGKB
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Pathways related to Hemiplegic Migraine according to GeneCards/GeneDecks:

(show top 50)    (show all 58)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9SCN1A, SCN5A
29.8ATP1B2, ATP1A2
3
Show member pathways
9.8ATP1A2, ATP1B2
49.6NOTCH3, ATP1A2, ATP1B2
5
Show member pathways
9.5GNAI2, ATP1A2, ATP1B2
69.3GNG2, GNB1
79.3GNG2, GNB1
89.3GNB1, GNG2
9
Show member pathways
9.3ATP1B2, ATP1A2, SCN1A, SCN5A
109.2SCN5A, GNAI2, ATP1A2, ATP1B2
11
Show member pathways
Cytoskeleton remodeling Reverse signaling by ephrin B61
9.0GNB1, GNG2, GNAI2
12
Show member pathways
Development A1 receptor signaling61
G protein signaling G Protein alpha q signaling cascades61
9.0GNAI2, GNG2, GNB1
13
Show member pathways
Signal transduction cAMP signaling61
9.0GNB1, GNG2, GNAI2
14
Show member pathways
Development Beta adrenergic receptors regulation of ERK61
G protein signaling G Protein alpha s signaling cascades61
G protein signaling G Protein beta gamma signaling cascades61
9.0GNB1, GNG2, GNAI2
15
Show member pathways
9.0GNAI2, GNG2, GNB1
16
Show member pathways
9.0GNAI2, GNG2, GNB1
17
Show member pathways
9.0GNB1, GNG2, GNAI2
18
Show member pathways
Apoptosis and survival BAD phosphorylation61
Development Alpha 2 adrenergic receptor activation of ERK61
Chemotaxis CXCR4 signaling pathway61
9.0GNB1, GNG2, GNAI2
19
Show member pathways
9.0GNB1, GNG2, GNAI2
20
Show member pathways
9.0GNAI2, GNG2, GNB1
21
Show member pathways
G protein signaling G Protein alpha 12 signaling pathway61
9.0GNAI2, GNG2, GNB1
229.0GNAI2, GNG2, GNB1
23
Show member pathways
9.0GNB1, GNG2, GNAI2
24
Show member pathways
9.0GNB1, GNG2, GNAI2
259.0GNAI2, GNG2, GNB1
269.0GNAI2, GNG2, GNB1
279.0GNB1, GNG2, GNAI2
28
Show member pathways
8.7CACNA1A, GNAI2, GNG2, GNB1
29
Show member pathways
8.7GNB1, GNG2, GNAI2, CACNA1A
30
Show member pathways
8.7GNB1, GNG2, GNAI2, CACNA1A
31
Show member pathways
8.7GNB1, GNG2, GNAI2, CACNA1A
32
Show member pathways
8.7GNB1, GNG2, GNAI2, CACNA1A
33
Show member pathways
8.7GNB1, GNG2, GNAI2, CACNA1A
34
Show member pathways
8.7GNB1, GNG2, GNAI2, CACNA1A
35
Show member pathways
8.7GNB1, GNG2, GNAI2, CACNA1A
36
Show member pathways
8.7GNB1, GNG2, GNAI2, CACNA1A
378.7GNB1, GNG2, GNAI2, CACNA1A
38
Show member pathways
8.7GNG2, GNB1, ATP1A2, ATP1B2
39
Show member pathways
8.6GNB1, GNG2, GNAI2, CALCA
408.6GNB1, GNG2, GNAI2, CALCA
41
Show member pathways
8.6GNB1, GNG2, GNAI2, OPRM1
42
Show member pathways
8.5GNAI2, GNG2, GNB1, ATP1B2
43
Show member pathways
8.5NOTCH3, CACNA1A, GNAI2, GNG2, GNB1
44
Show member pathways
8.3GNB1, GNG2, GNAI2, CALCA, OPRM1
45
Show member pathways
8.3GNB1, GNG2, GNAI2, CALCA, OPRM1
46
Show member pathways
8.2GNB1, GNG2, GNAI2, SCN1A, SCN5A, CACNA1A
47
Show member pathways
8.2GNB1, GNG2, GNAI2, SCN1A, SCN5A, CACNA1A
48
Show member pathways
8.2GNB1, GNG2, GNAI2, SCN1A, CACNA1A, OPRM1
49
Show member pathways
8.0GNB1, GNG2, GNAI2, CALCA, OPRM1, NOTCH3
50
Show member pathways
Calcium Regulation in the Cardiac Cell39
8.0CALCA, CACNA1A, GNAI2, GNG2, GNB1, ATP1B2

Compounds for genes affiliated with Hemiplegic Migraine

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Sources:
30IUPHAR, 62Tocris Bioscience, 46Novoseek, 25HMDB, 12DrugBank, 52PharmGKB
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Compounds related to Hemiplegic Migraine according to GeneCards/GeneDecks:

(show all 35)
idCompoundScoreTop Affiliating Genes
1bc-iii3010.3SCN1A, SCN5A
2atx-ii3010.3SCN1A, SCN5A
3aft-ii3010.3SCN1A, SCN5A
4batrachotoxin3010.3SCN1A, SCN5A
5qx 314 chloride6210.2SCN1A, SCN5A
6tetrodotoxin citrate6210.2SCN1A, SCN5A
7phrixotoxin 36210.2SCN1A, SCN5A
8veratridine46 62 3012.2SCN1A, SCN5A
9lithium carbonate6210.2ATP1B2, ATP1A2
10loperamide46 25 1212.1CACNA1A, OPRM1
11tetrodotoxin46 62 3012.0CALCA, SCN5A, SCN1A
12zonisamide46 52 1211.9SCN5A, SCN1A
13heroin46 52 1211.9CALCA, OPRM1
14lidocaine46 30 1211.7OPRM1, SCN5A
15bepridil46 30 1211.7DNAH8, CACNA1A
16ether46 5210.5CALCA, DNAH8
17sodium46 2510.5ATP1B2, ATP1A2, SCN1A, SCN5A, CACNA1A
18verapamil46 30 52 25 1213.4CACNA1A, DNAH8, SCN5A
19digoxin46 62 52 25 1213.4DNAH8, ATP1A2, ATP1B2
20gallein629.4GNAI2, GNG2, GNB1
21clonidine46 52 30 1212.4DNAH8, CALCA, OPRM1
22g-protein antagonist peptide629.4GNAI2, GNG2, GNB1
23suramin hexasodium salt629.4GNB1, GNG2, GNAI2
248-bromo-cgmp, sodium salt629.4GNB1, GNG2, GNAI2
25pertussis toxin629.4GNB1, GNG2, GNAI2
265-hydroxytryptamine469.2OPRM1, CALCA, DNAH8
27potassium46 25 1211.1OPRM1, CACNA1A, SCN5A, SCN1A, ATP1A2, ATP1B2
28Guanosine monophosphate259.1GNAI2, GNG2, GNB1
29acetylcholine46 52 30 25 1213.1OPRM1, CALCA, CACNA1A, DNAH8
30glutamine469.1SCN5A, DNAH8, CACNA1A, OPRM1
31quinidine46 30 52 1212.1DNAH8, SCN5A
32Guanosine diphosphate259.0GNAI2, GNG2, GNB1
33epinephrine46 25 1211.0DNAH8, CALCA, OPRM1
34glutamate468.9ATP1A2, DNAH8, CACNA1A, CALCA, OPRM1
35calcium46 52 25 1211.3ATP1A2, SCN5A, DNAH8, CACNA1A, CALCA, OPRM1

GO Terms for genes affiliated with Hemiplegic Migraine

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Sources:
17Gene Ontology
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Cellular components related to Hemiplegic Migraine according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sodium:potassium-exchanging ATPase complexGO:0058909.8ATP1A2, ATP1B2
2voltage-gated sodium channel complexGO:0015189.8SCN1A, SCN5A
3T-tubuleGO:0303159.8ATP1A2, SCN1A, SCN5A
4neuronal cell bodyGO:0430259.7CALCA, CACNA1A, SCN1A
5intercalated discGO:0147049.6SCN5A, SCN1A
6heterotrimeric G-protein complexGO:0058349.0GNAI2, GNG2, GNB1
7plasma membraneGO:0058867.1NOTCH3, ATP1B2, ATP1A2, GNB1, GNG2, GNAI2

Biological processes related to Hemiplegic Migraine according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1neuromuscular process controlling postureGO:05088410.2PRRT2, SCN1A
2regulation of cardiac muscle cell contractionGO:08600410.2SCN5A, ATP1A2
3negative regulation of cytosolic calcium ion concentrationGO:05148110.2OPRM1, ATP1A2
4membrane depolarizationGO:05189910.1CACNA1A, SCN5A
5gamma-aminobutyric acid signaling pathwayGO:00721410.1CACNA1A, GNAI2
6sodium ion transportGO:00681410.0ATP1A2, SCN1A, SCN5A
7regulation of heart rateGO:00202710.0CALCA, SCN5A
8adult walking behaviorGO:0076289.9CACNA1A, SCN1A
9negative regulation of adenylate cyclase activityGO:0071949.9GNAI2, OPRM1
10G-protein coupled acetylcholine receptor signaling pathwayGO:0072139.9GNB1, GNAI2
11adenylate cyclase-inhibiting G-protein coupled receptor signaling pathwayGO:0071939.8OPRM1, GNAI2
12cellular response to catecholamine stimulusGO:0718709.7GNG2, GNB1
13cellular response to prostaglandin E stimulusGO:0713809.6GNG2, GNB1
14sodium ion transmembrane transportGO:0357259.6ATP1B2, ATP1A2, SCN1A, SCN5A
15positive regulation of cytosolic calcium ion concentrationGO:0072049.4OPRM1, CALCA, CACNA1A, GNB1
16energy reserve metabolic processGO:0061129.4GNB1, GNG2, CACNA1A
17adenylate cyclase-activating dopamine receptor signaling pathwayGO:0071919.3OPRM1, GNG2, GNB1
18cellular response to glucagon stimulusGO:0713779.3GNB1, GNG2
19phospholipase C-activating G-protein coupled receptor signaling pathwayGO:0072009.3OPRM1, GNB1
20platelet activationGO:0301689.0GNAI2, GNG2, GNB1
21synaptic transmissionGO:0072689.0CACNA1A, GNAI2, GNG2, GNB1
22blood coagulationGO:0075968.8ATP1B2, GNB1, GNG2, GNAI2

Molecular functions related to Hemiplegic Migraine according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sodium:potassium-exchanging ATPase activityGO:0053919.8ATP1A2, ATP1B2
2voltage-gated sodium channel activityGO:0052489.8SCN5A, SCN1A
3voltage-gated calcium channel activityGO:0052459.6OPRM1, CACNA1A
4signal transducer activityGO:0048719.0GNAI2, GNG2, GNB1

Products for genes affiliated with Hemiplegic Migraine

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Sources for Hemiplegic Migraine

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet