MCID: HMG012
MIFTS: 18

Hemoglobin Constant Spring malady

Categories: Genetic diseases, Blood diseases

Aliases & Classifications for Hemoglobin Constant Spring

Aliases & Descriptions for Hemoglobin Constant Spring:

Name: Hemoglobin Constant Spring 24 29

Classifications:



Summaries for Hemoglobin Constant Spring

MalaCards based summary : Hemoglobin Constant Spring is related to thalassemia and hereditary spherocytosis. An important gene associated with Hemoglobin Constant Spring is HBA2 (Hemoglobin Subunit Alpha 2). The drugs Tenofovir and rituximab have been mentioned in the context of this disorder. Affiliated tissues include testes.

Related Diseases for Hemoglobin Constant Spring

Diseases related to Hemoglobin Constant Spring via text searches within MalaCards or GeneCards Suite gene sharing:

id Related Disease Score Top Affiliating Genes
1 thalassemia 10.2
2 hereditary spherocytosis 9.9
3 pulmonary embolism 9.9

Symptoms & Phenotypes for Hemoglobin Constant Spring

Drugs & Therapeutics for Hemoglobin Constant Spring

Drugs for Hemoglobin Constant Spring (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tenofovir Approved, Investigational Phase 4,Phase 3 147127-20-6 464205
2
rituximab Approved Phase 4,Phase 3 174722-31-7 10201696
3
Entecavir Approved, Investigational Phase 4,Phase 3 142217-69-4 153941
4
Telbivudine Approved, Investigational Phase 4 3424-98-4 159269
5 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3
6 Vaccines Phase 4,Phase 1
7 Immunoglobulins Phase 4,Phase 1,Phase 2
8 Anti-HIV Agents Phase 4,Phase 3
9 Anti-Infective Agents Phase 4,Phase 3
10 Anti-Retroviral Agents Phase 4,Phase 3
11 Reverse Transcriptase Inhibitors Phase 4,Phase 3
12 Antibodies Phase 4,Phase 1,Phase 2
13 Antiviral Agents Phase 4,Phase 3
14 Tin Fluorides Phase 4
15
Oxaliplatin Approved, Investigational Phase 2 61825-94-3 5310940 9887054 6857599, 9887054 43805
16 Tegafur Approved Phase 2 17902-23-7
17
Fluorouracil Approved Phase 2 51-21-8 3385
18
leucovorin Approved, Nutraceutical Phase 2 58-05-9 54575, 6560146 143
19
s 1 (combination) Phase 2
20 Hepatitis C Antibodies Phase 2
21 gamma-Globulins Phase 1, Phase 2
22 Immunoglobulins, Intravenous Phase 1, Phase 2
23 Rho(D) Immune Globulin Phase 1, Phase 2
24 Antibodies, Monoclonal Phase 2
25
Artesunate Approved 88495-63-0 6917864 5464098
26
Amodiaquine Approved 86-42-0 2165
27
Benzocaine Approved 1994-09-7, 94-09-7 2337
28
Doxorubicin Approved, Investigational 23214-92-8 31703
29
Vincristine Approved, Investigational 2068-78-2, 57-22-7 5978
30
Cyclophosphamide Approved, Investigational 50-18-0, 6055-19-2 2907
31
Prednisolone Approved, Vet_approved 50-24-8 5755
32
Methylprednisolone Approved, Vet_approved 83-43-2 6741
33 tannic acid Approved, Nutraceutical
34
Doxil Approved June 1999 31703
35 Antirheumatic Agents
36 Liver Extracts
37 Immunosuppressive Agents
38 Prednisolone acetate
39 Prednisolone hemisuccinate
40 Prednisolone phosphate
41 Methylprednisolone acetate
42 Methylprednisolone Hemisuccinate

Interventional clinical trials:

(show all 39)
id Name Status NCT ID Phase
1 Seroprevalence of Hepatitis B and Immune Response to Hepatitis B Vaccination in Chinese College Students Completed NCT01861613 Phase 4
2 Prophylactic Use of Entecavir for Non-Hodgkin's Lymphoma Patients With Resolved Hepatitis B Completed NCT00926757 Phase 4
3 VaxTeen Hepatitis B Vaccine Booster Study Completed NCT00144313 Phase 4
4 Telbivudine Therapy in HBeAg-positive Pregnant Women to Prevent Mother-to-infant Transmission of HBV Completed NCT01637844 Phase 4
5 To Compare the Efficacy of a Prophylactic Use of Tenofovir by Duration for the Non-Hodgkin's Lymphoma Recruiting NCT02585947 Phase 4
6 The Clinical Trial of the Anti Hepatitis B Placenta Transfer Factor Injection Active, not recruiting NCT02412319 Phase 4
7 Tenofovir to Prevent HBV Reactivation Unknown status NCT02186574 Phase 3
8 Evaluation of Homeopathic Treatment for Hot Flashes in Non Metastatic Breast Cancer Completed NCT01246427 Phase 3
9 Study of Anti-Viral Prophylaxis for HBsAg(+) or HBcAb(+)/HBsAb(-) Patients Starting Anti-TNFα Terminated NCT01694264 Phase 3
10 Safety and Pharmacokinetics Study of Anthrax Immune Globulin Intravenous (AIGIV) Completed NCT00845650 Phase 1, Phase 2
11 RP II Study of SOX vs mFOLFOX6 in Patients With Resectable Rectal Cancer (KSCC1301). Recruiting NCT02280070 Phase 2
12 Long-term Efficacy and Safety of Repeated Ofatumumab Treatment Courses in RA Patients Who Previously Received Ofatumumab or Placebo in Trial Hx-CD20-403 Terminated NCT00655824 Phase 2
13 Determining Responses to Two Different Vaccines in HIV and HCV Infected Individuals Completed NCT00393276 Phase 1
14 Rapid Diagnostics for HIV and Hepatitis Unknown status NCT02190305
15 Prevalence of Occult HBV Infection Among Anti-HBc Alone Group in Northern Taiwan Unknown status NCT01396538
16 Seroprevalence of Hepatitis B Infection and Effect of Booster Response Amongst Taiwanese Young Adults Unknown status NCT00702663
17 Risk of Hepatitis B Reactivation in Patients With Prior HBV Exposure Undergoing Rituximab-containing Chemotherapy: A Prospective Study Unknown status NCT01502397
18 Factors Influencing Hepatitis B Virus Reactivation in Lymphoma Patients Treated With Rituximab Unknown status NCT01311232
19 Hyperbilirubinemia After Cardiac Surgery Unknown status NCT01617902
20 Expression of Th9 Cells and Poor/Non-responsiveness to Hepatitis B Vaccination Unknown status NCT01441609
21 Utility of Urinary beta2 Microglobulin as an Early Marker of Renal Dysfunction in Vietnamese HIV-Infected Patients Unknown status NCT02256579
22 Isolated Anti-HBc Serological Profile in HIV Infected Patients: Immunological, Virological Characteristics and Response to Hepatitis B Vaccination Completed NCT02323308
23 Activation of Hepatitis B Virus (HBV) in Hepatitis B Surface Antigen (HBsAg) - Negative But Hepatitis B Core Antibody (Anti-HBc) - Positive Patients Completed NCT00881036
24 A Trial of 2 'Point of Care' Diagnostic Methods to Improve Detection and Treatment of Anaemia in African Children Completed NCT00439595
25 A Study to Test the Efficacy of the HBV Vaccine and to Look at the Prevalence of HBV Infection Completed NCT00476411
26 Risk of Hepatitis B Reactivation After Bone Marrow Transplantation With Prior Hepatitis B Virus (HBV) Exposure Completed NCT01481649
27 Examination of Protective Factors Against Severe Malaria Completed NCT00342043
28 A Controlled Prospective Study of Transfusion-Associated Hepatitis Completed NCT00004848
29 Hepatitis B Virus Vertical Transmission From HIV-HBV Co-infected Women Completed NCT02044068
30 Optimizing Integrated PMTCT Services in Rural North-Central Nigeria Completed NCT01805752
31 Trial to Improve Access to PMTCT Services and Reduce HIV Transmission From Mother to Child Completed NCT01932138
32 Study to Assess Seroprevalence of Hepatitis A, Hepatitis B and Bordetella Pertussis in Mexico Completed NCT02112890
33 Laboratory Profile of Hepatitis B and C in Users of a Reference Service Completed NCT00512941
34 Widespread vs. Selective Screening for Hepatitis B Infection Prior to Chemotherapy Recruiting NCT01970254
35 Is Hepatitis B Surface Antigen (HB s Ag) Enough Alone as a Screening Test Before Immunosuppressive Therapies? Recruiting NCT02799316
36 Ipilimumab 60-month Pharmacovigilance Protocol for Advanced Melanoma Patients Who Are Hepatitis B and/or Hepatitis C Virus Positive in Taiwan Recruiting NCT02402699
37 Effects of a Bicycling Intervention on Cognitive Skills and Cardiovascular Health Recruiting NCT02453178
38 Incidence of Hepatitis B Reactivation in Non-Hodgkin's Lymphoma Patients Active, not recruiting NCT00931229
39 Compliance of Traditional Chinese Medicine in Young Patients With Rheumatic Diseases Enrolling by invitation NCT02260323

Search NIH Clinical Center for Hemoglobin Constant Spring

Genetic Tests for Hemoglobin Constant Spring

Genetic tests related to Hemoglobin Constant Spring:

id Genetic test Affiliating Genes
1 Hemoglobin Constant Spring 29 24 HBA2

Anatomical Context for Hemoglobin Constant Spring

MalaCards organs/tissues related to Hemoglobin Constant Spring:

39
Testes

Publications for Hemoglobin Constant Spring

Articles related to Hemoglobin Constant Spring:

(show all 29)
id Title Authors Year
1
Detection of the heterozygote of hemoglobin Constant Spring by I+-thalassemia immunochromatographic strip test. ( 27227710 )
2016
2
Hemoglobin Constant Spring (Hb CS) Missed by HPLC in an Hb E Trait Pregnancy Resulting in Hb H-CS Disease in a Thai Girl: Utility of Capillary Electrophoresis. ( 27408407 )
2016
3
Hemoglobin Constant Spring among Southeast Asian Populations: Haplotypic Heterogeneities and Phylogenetic Analysis. ( 26683994 )
2015
4
Hemoglobin Constant Spring exhibits prolonged ex vivo stability when assessed by HPLC. ( 25863109 )
2015
5
Hemoglobin Constant Spring is markedly high in women of an ethnic minority group in Vietnam: A community-based survey and hematologic features. ( 24368026 )
2013
6
Quantification of hemoglobin Constant Spring in heterozygote and homozygote by a capillary electrophoresis method. ( 21883970 )
2012
7
Rapid identification of heterozygous and homozygous hemoglobin constant spring by SYTO9 with a high resolution melting analysis. ( 22997986 )
2012
8
Application of an expanded multiplex genotyping assay for the simultaneous detection of Hemoglobin Constant Spring and common deletional alpha-thalassemia mutations. ( 19919622 )
2010
9
Molecular confirmatory testing of hemoglobin Constant Spring by real-time polymerase chain reaction SYBR Green1 with high-resolution melting analysis. ( 20214676 )
2010
10
Hemoglobin constant spring can interfere with glycated hemoglobin measurements by boronate affinity chromatography. ( 17202499 )
2007
11
Anemia and hydrops in a fetus with homozygous hemoglobin constant spring. ( 17164653 )
2006
12
Peripartum pulmonary embolism in a patient with concomitant hemoglobin Newcastle, hemoglobin Constant Spring, and hereditary spherocytosis. ( 16184591 )
2005
13
Atypical hemoglobin H disease in a Thai patient resulting from a combination of alpha-thalassemia 1 and hemoglobin Constant Spring with hemoglobin J Bangkok heterozygosity. ( 11422410 )
2001
14
Homozygous hemoglobin constant spring with normal electrophoresis. A possible cause for under-diagnosis. ( 9668571 )
1998
15
The unusual pathobiology of hemoglobin constant spring red blood cells. ( 9057661 )
1997
16
Rapid diagnosis of hemoglobin constant spring and hemoglobin E by amplified created restriction sites. ( 8422476 )
1993
17
Asymmetrically primed selective amplification/temperature shift fluorescence polymerase chain reaction to detect the hemoglobin Constant Spring mutation. ( 1712643 )
1991
18
Hemoglobin constant spring in Bangkok: molecular screening by selective enzymatic amplification of the alpha 2-globin gene. ( 1746536 )
1991
19
Selective enzymatic amplification of alpha 2-globin DNA for detection of the hemoglobin Constant Spring mutation. ( 2713511 )
1989
20
Decreased sensitivity of artesunate and chloroquine of Plasmodium falciparum infecting hemoglobin H and/or hemoglobin constant spring erythrocytes. ( 2643631 )
1989
21
Hemoglobin constant spring defined by specific oligonucleotide hybridization and hemoglobin D Punjab (beta 121----Gln) in a Batak Indonesian family. ( 3177365 )
1988
22
Impaired parasite growth and increased susceptibility to phagocytosis of Plasmodium falciparum infected alpha-thalassemia or hemoglobin Constant Spring red blood cells. ( 3281435 )
1988
23
Hemoglobin H disease with hemoglobin Constant Spring in a child of Laotian extraction. ( 3764529 )
1986
24
Hemoglobin Constant Spring in China. ( 3997543 )
1985
25
Hematologic and biosynthetic studies in homozygous hemoglobin Constant Spring. ( 6725554 )
1984
26
Hemoglobin constant spring (HbCS) and CS type hemoglobin H disease: a 3 family survey. ( 116823 )
1979
27
Hemoglobin Constant Spring: hemoglobin synthesis in heterozygous and homozygous states. ( 1147948 )
1975
28
Hemoglobin Constant Spring, and unusual alpha-chain variant involved in the etiology of hemoglobin H disease. ( 4606609 )
1974
29
Hemoglobin Constant Spring (slow-moving hemoglobin X components) and hemoglobin e in Malayan aborigines. ( 4716657 )
1973

Variations for Hemoglobin Constant Spring

ClinVar genetic disease variations for Hemoglobin Constant Spring:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 HBA2 NM_000517.4(HBA2): c.427T> C (p.Ter143Gln) single nucleotide variant Pathogenic rs41464951 GRCh37 Chromosome 16, 223597: 223597

Expression for Hemoglobin Constant Spring

Search GEO for disease gene expression data for Hemoglobin Constant Spring.

Pathways for Hemoglobin Constant Spring

GO Terms for Hemoglobin Constant Spring

Sources for Hemoglobin Constant Spring

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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