MCID: HMG004
MIFTS: 24

Hemoglobin D Disease malady

Blood category

Summaries for Hemoglobin D Disease

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33MalaCards
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MalaCards: Hemoglobin D Disease, also known as hb-d disease, is related to sickle cell - hemoglobin d disease and hemoglobin c disease. An important gene associated with Hemoglobin D Disease is HBB (hemoglobin, beta). Affiliated tissues include bone marrow, whole blood and spleen.

Aliases & Classifications for Hemoglobin D Disease

Sources:
8Disease Ontology, 49Orphanet, 61UMLS, 40NCIt, 57SNOMED-CT, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Blood


Characteristics (Orphanet epidemiological data):

49
hemoglobin d disease:
Age of onset: Childhood


Aliases & Descriptions:

hemoglobin d disease 8 49 61
hb-d disease 8


External Ids:

Disease Ontology8 DOID:5378
NCIt40 C35344
ICD10 via Orphanet26 D58.2
SNOMED-CT57 66729008
SNOMED-CT via Orphanet58 66729008
UMLS via Orphanet62 C0272080

Related Diseases for Hemoglobin D Disease

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Hemoglobin D Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1sickle cell - hemoglobin d disease10.5
2hemoglobin c disease10.5
3sickle cell disease10.4
4sickle cell - hemoglobin c disease10.4
5acute chest syndrome10.1
6thromboembolism10.1

Graphical network of diseases related to Hemoglobin D Disease:



Diseases related to hemoglobin d disease

Clinical Features for Hemoglobin D Disease

Drugs & Therapeutics for Hemoglobin D Disease

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Hemoglobin D Disease

Drug clinical trials:

Search ClinicalTrials for Hemoglobin D Disease

Search NIH Clinical Center for Hemoglobin D Disease

Search CenterWatch for Hemoglobin D Disease

Genetic Tests for Hemoglobin D Disease

Anatomical Context for Hemoglobin D Disease

Sources:
33MalaCards
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MalaCards organs/tissues related to Hemoglobin D Disease:

33
Bone marrow, Whole blood, Spleen, Brain, Heart, Colon, Kidney, Liver, Lung, B cells, Fetal brain, Fetal liver, Fetal lung

Animal Models for Hemoglobin D Disease or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Hemoglobin D Disease

Sources:
51PubMed
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Articles related to Hemoglobin D Disease:

(show top 50)    (show all 316)
idTitleAuthorsYear
1
Transcranial Doppler and brain MRI in children with sickle cell disease and high hemoglobin F levels. (24038756)
2014
2
Hemoglobin a1c is associated with increased risk of incident coronary heart disease among apparently healthy, nondiabetic men and women. (23537807)
2013
3
Prevalence and risk factors for pulmonary hypertension in patients with hemoglobin E/I^-thalassemia disease. (24330103)
2013
4
Human bulbar conjunctival hemodynamics in hemoglobin SS and SC disease. (23657867)
2013
5
Haptoglobin genotype is a consistent marker of coronary heart disease risk among individuals with elevated glycosylated hemoglobin. (23312704)
2013
6
Detection of acquired hemoglobinopathy in children with hematological malignancies at disease onset: results form a national referral centre. (24096989)
2013
7
Massive hemothorax due to intrathoracic extramedullary hematopoiesis in a patient with beta thalassemia hemoglobin E disease. (24319860)
2013
8
A novel fusion gene and a common I+(0)-thalassemia deletion cause hemoglobin H disease in a Chinese family. (23481460)
2013
9
Impact of postoperative nadir hemoglobin and blood transfusion on outcomes after operations for atherosclerotic vascular disease. (23384496)
2013
10
Prevalence of sickle cell disease, hemoglobin S, and hemoglobin C among Haitian newborns. (23757318)
2013
11
Pulmonary thromboembolism in a child with sickle cell hemoglobin d disease in the setting of acute chest syndrome. (24159402)
2013
12
Therapeutic hemoglobin levels after gene transfer in I^-thalassemia mice and in hematopoietic cells of I^-thalassemia and sickle cells disease patients. (22479321)
2012
13
First report of successful stem cell transplantation in a patient with sickle cell hemoglobin D disease. (20502357)
2010
14
Marchiafava-Bignami disease complicating SC hemoglobin disease and Plasmodium falciparum infection. (20537852)
2010
15
Detection of uncommon deletions in alpha-thalassemia using the pcr-reverse dot-blot method for prenatal diagnosis of nondeletional hemoglobin H disease. (20516677)
2010
16
Thrombotic thrombocytopenic purpura and multiorgan system failure in a child with sickle cell-hemoglobin C disease. (19525485)
2010
17
Correction of murine sickle cell disease using gamma-globin lentiviral vectors to mediate high-level expression of fetal hemoglobin. (19050697)
2009
18
Deoxygenated hemoglobin/myoglobin kinetics of forearm muscles from rest to exercise in patients with chronic obstructive pulmonary disease. (19155602)
2009
19
What is so bad about a hemoglobin level of 12 to 13 g/dL for chronic kidney disease patients anyway? (19233072)
2009
20
Impact of hemoglobin concentration on plasma B-type natriuretic peptide level and left ventricle echocardiographics characteristics in chronic kidney disease patients. (20120531)
2009
21
Mutations and polymorphisms in hemoglobin genes and the risk of pulmonary hypertension and death in sickle cell disease. (17724704)
2008
22
Usefulness of fecal lactoferrin and hemoglobin in diagnosis of colorectal diseases. (17461450)
2007
23
Severe beta(0) thalassemia/hemoglobin E disease caused by de novo 22-base pair duplication in the paternal allele of beta globin gene. (17160997)
2007
24
Update on erythropoietin treatment: should hemoglobin be normalized in patients with chronic kidney disease? (16565252)
2006
25
Paroxysmal nocturnal hemoglobinuria: an acquired X-linked genetic disease with somatic-cell mosaicism. (16650759)
2006
26
Sickle cell hemoglobin C disease in Saudi Arabia. (12682691)
2003
27
Hemoglobin E beta-thalassemia: an increasingly common disease with some diagnostic pitfalls. (9602183)
1998
28
Hemosiderosis with diabetes mellitus in untransfused Hemoglobin H disease. (9462550)
1998
29
Intrathoracic extramedullary hematopoietic tumor in hemoglobin C disease. (9140301)
1997
30
Identification of a novel termination codon mutation (TAA-->TAT, Term-->Tyr) in the alpha 2 globin gene of a Laotian girl with hemoglobin H disease. (8193381)
1994
31
Thrombotic thrombocytopenic purpura associated with sickle cell-hemoglobin C disease. (7973909)
1994
32
Variable degrees of suppression of hemoglobin S synthesis in subjects with hemoglobin SS disease on a long-term transfusion regimen. (8301425)
1994
33
Erythropoietin in chronic obstructive pulmonary disease. Relationship between serum erythropoietin, blood hemoglobin and lung function--effect of the calcium antagonist isradipine on serum erythropoietin. (1836066)
1991
34
Cerebral thrombosis in beta-thalassemia/hemoglobin E disease. (2339462)
1990
35
Splenic infarction at low altitude in a child with hemoglobin S-C disease. (3042248)
1988
36
Hemoglobin H disease with hemoglobin Constant Spring in a child of Laotian extraction. (3764529)
1986
37
Regulation of cation content and cell volume in hemoglobin erythrocytes from patients with homozygous hemoglobin C disease. (3998150)
1985
38
Splenic infarction, splenic sequestration, and functional hyposplenism in hemoglobin S-C disease. (3976642)
1985
39
Life-threatening complications in a child with hemoglobin SD-Los Angeles disease. (6547933)
1984
40
Acquired hemoglobin H disease in a case of refractory anemia with excess of blasts (RAEB) evolving into acute nonlymphoid leukemia. (6433631)
1984
41
Sickle-cell hemoglobin C disease in pregnancy: report of a case with review of the literature. (7380681)
1980
42
Severe proliferative retinopathy as the only sign of sickle cell hemoglobin C disease. (1275039)
1976
43
A third case of hemoglobin Memphis-sickle cell disease. Whole blood viscosity used as a screening test. (4743350)
1973
44
Oral manifestations of hemoglobinopathies. A case of homozygous hemoglobin C disease diagnosed as a result of dental radiographic changes. (5273837)
1970
45
Homozygous hemoglobin C disease: Clinical review of fifteen patients. (5643614)
1968
46
Thalassemia--hemoglobin C disease in white siblings. (5989222)
1966
47
Sickle cell-hemoglobin C disease; report of a case associated with sudden coma in the puerperium. (13633147)
1959
48
Splenic infarction in a patient with sickle-cell-hemoglobin-c disease; report of a case occurring following air travel. (13354018)
1956
49
Thalassemia-hemoglobin C disease in white siblings. (13322518)
1956
50
Homozygous hemoglobin C disease; report of a case with studies on the pathophysiology and neonatal formation of hemoglobin C. (14361465)
1955

Genetic Variations for Hemoglobin D Disease

Expression for genes affiliated with Hemoglobin D Disease

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hemoglobin D Disease

Search GEO for disease gene expression data for Hemoglobin D Disease.

Pathways for genes affiliated with Hemoglobin D Disease

Compounds for genes affiliated with Hemoglobin D Disease

GO Terms for genes affiliated with Hemoglobin D Disease

Products for genes affiliated with Hemoglobin D Disease

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hemoglobin D Disease

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet