MCID: HMG015
MIFTS: 16

Hemoglobin S Beta-Thalassemia

Categories: Genetic diseases, Blood diseases

Aliases & Classifications for Hemoglobin S Beta-Thalassemia

MalaCards integrated aliases for Hemoglobin S Beta-Thalassemia:

Name: Hemoglobin S Beta-Thalassemia 24
Sickle Cell-Beta-Thalassemia 69

Classifications:



Summaries for Hemoglobin S Beta-Thalassemia

MalaCards based summary : Hemoglobin S Beta-Thalassemia, also known as sickle cell-beta-thalassemia, is related to thalassemia and down syndrome. An important gene associated with Hemoglobin S Beta-Thalassemia is HBB (Hemoglobin Subunit Beta). The drugs Nitric Oxide and alemtuzumab have been mentioned in the context of this disorder. Affiliated tissues include liver, pancreas and heart.

Related Diseases for Hemoglobin S Beta-Thalassemia

Diseases related to Hemoglobin S Beta-Thalassemia via text searches within MalaCards or GeneCards Suite gene sharing:

id Related Disease Score Top Affiliating Genes
1 thalassemia 10.2
2 down syndrome 9.9

Symptoms & Phenotypes for Hemoglobin S Beta-Thalassemia

Drugs & Therapeutics for Hemoglobin S Beta-Thalassemia

Drugs for Hemoglobin S Beta-Thalassemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 67)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nitric Oxide Approved Phase 2,Phase 1 10102-43-9 145068
2
alemtuzumab Approved, Investigational Phase 1, Phase 2,Early Phase 1 216503-57-0
3
Busulfan Approved, Investigational Phase 1, Phase 2,Early Phase 1 55-98-1 2478
4
Cyclophosphamide Approved, Investigational Phase 1, Phase 2 50-18-0, 6055-19-2 2907
5
Everolimus Approved Phase 1, Phase 2 159351-69-6 6442177
6
Fludarabine Approved Phase 1, Phase 2, Early Phase 1 21679-14-1, 75607-67-9 30751
7
Melphalan Approved Phase 1, Phase 2,Early Phase 1 148-82-3 4053 460612
8
Methylprednisolone Approved, Vet_approved Phase 1, Phase 2 83-43-2 6741
9
Prednisolone Approved, Vet_approved Phase 1, Phase 2 50-24-8 5755
10
Sirolimus Approved, Investigational Phase 1, Phase 2 53123-88-9 5284616 6436030 46835353
11
Tacrolimus Approved, Investigational Phase 1, Phase 2 104987-11-3 445643 439492
12 Thiotepa Approved Phase 1, Phase 2 52-24-4 5453
13 Anti-Asthmatic Agents Phase 2,Phase 1
14 Antioxidants Phase 2,Phase 1
15 Autonomic Agents Phase 2,Phase 1
16 Bronchodilator Agents Phase 2,Phase 1
17 Endothelium-Dependent Relaxing Factors Phase 2,Phase 1
18 Neurotransmitter Agents Phase 2,Phase 1
19 Peripheral Nervous System Agents Phase 2,Phase 1
20 Protective Agents Phase 2,Phase 1
21 Respiratory System Agents Phase 2,Phase 1
22 Vasodilator Agents Phase 2,Phase 1
23 Gastrointestinal Agents Phase 1, Phase 2
24 Liver Extracts Phase 1, Phase 2
25 Alkylating Agents Phase 1, Phase 2
26 Antiemetics Phase 1, Phase 2
27 Anti-Inflammatory Agents Phase 1, Phase 2
28 Antimetabolites Phase 1, Phase 2
29 Antimetabolites, Antineoplastic Phase 1, Phase 2
30 Antineoplastic Agents, Hormonal Phase 1, Phase 2
31 Antirheumatic Agents Phase 1, Phase 2
32 Calcineurin Inhibitors Phase 1, Phase 2
33 glucocorticoids Phase 1, Phase 2
34 Hormone Antagonists Phase 1, Phase 2
35 Hormones Phase 1, Phase 2
36 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1, Phase 2
37 Immunosuppressive Agents Phase 1, Phase 2
38 Methylprednisolone acetate Phase 1, Phase 2
39 Methylprednisolone Hemisuccinate Phase 1, Phase 2
40 Neuroprotective Agents Phase 1, Phase 2
41 Pharmaceutical Solutions Phase 1, Phase 2
42 Prednisolone acetate Phase 1, Phase 2
43 Prednisolone hemisuccinate Phase 1, Phase 2
44 Prednisolone phosphate Phase 1, Phase 2
45
Hydroxyurea Approved Phase 1 127-07-1 3657
46
Miconazole Approved, Investigational, Vet_approved Phase 1 22916-47-8 4189
47
Panobinostat Approved, Investigational Phase 1 404950-80-7 6918837
48 Nitric Oxide Donors Phase 1
49 Nucleic Acid Synthesis Inhibitors Phase 1
50 Phosphodiesterase 5 Inhibitors Phase 1

Interventional clinical trials:

(show all 17)

id Name Status NCT ID Phase Drugs
1 Nitric Oxide Inhalation to Treat Sickle Cell Pain Crises Completed NCT00094887 Phase 2 Nitric Oxide;Placebo
2 CD34+ (Malignant) Stem Cell Selection for Patients Receiving Allogenic Stem Cell Transplant Recruiting NCT02061800 Phase 1, Phase 2 Thiotepa;Cyclophosphamide;Alemtuzumab;Tacrolimus;Melphalan;Busulfan;Fludarabine;Methylprednisolone
3 Evaluation of Hydroxyurea Plus L-arginine or Sildenafil to Treat Sickle Cell Anemia Completed NCT00056433 Phase 1 Hydroxyurea;L-Arginine;Sildenafil
4 Haploidentical Hematopoietic Stem Cell Transplantation Recruiting NCT02165007 Phase 1 peripheral blood stem cell graft that are CD34+ selected
5 The Role of Endothelin-1 in Sickle Cell Disease Recruiting NCT02712346 Phase 1 Ambrisentan;Placebo
6 Study of Panobinostat (LBH589) in Patients With Sickle Cell Disease Recruiting NCT01245179 Phase 1 panobinostat
7 The Spleen in Sickle Cell Anemia and Sickle Cell Thalassemia Completed NCT00971698
8 Clinical and Laboratory Assessment of Iron Overload in Sickle Cell Anemia and Sickle Cell Thalassemia Completed NCT00512564
9 Iron Overload Assesment in Sickle Cell Anemia and Sickle Cell Thalassemia Completed NCT00512226
10 MRI Evaluation of Iron Overload in the Heart, Liver and Pancreas in Patients Receiving Multiple Blood Transfusions. Completed NCT00629291
11 Clinical and Laboratory Characteristics of Sickle Cell Anemia Patients Admitted With Fever Completed NCT00736060
12 Long Term Follow up in Sickle Cell Patients Treated by Hydroxyurea Completed NCT00480974
13 Iron Overload and Growth Velocity in Thalassemia and Sickle Cell Anemia Completed NCT00972231
14 Sickle Cell Anemia in an Arab Bedouin Village in the Northern Israel Completed NCT00481039
15 Hepcidin Levels in Sickle Cell Disease (SCD) Completed NCT02258997
16 CD34+ (Non-Malignant) Stem Cell Selection for Patients Receiving Allogeneic Stem Cell Transplantation Recruiting NCT01966367 Early Phase 1
17 Sickle Cell Anemia - A Comparative Study Between Three Ethnical Communities, a Multicenter Study Recruiting NCT01905787

Search NIH Clinical Center for Hemoglobin S Beta-Thalassemia

Genetic Tests for Hemoglobin S Beta-Thalassemia

Genetic tests related to Hemoglobin S Beta-Thalassemia:

id Genetic test Affiliating Genes
1 Hemoglobin S Beta-Thalassemia 24 HBB

Anatomical Context for Hemoglobin S Beta-Thalassemia

MalaCards organs/tissues related to Hemoglobin S Beta-Thalassemia:

39
Liver, Pancreas, Heart, Spleen

Publications for Hemoglobin S Beta-Thalassemia

Articles related to Hemoglobin S Beta-Thalassemia:

id Title Authors Year
1
Fatal fat embolism syndrome in a child with undiagnosed hemoglobin S/beta+ thalassemia: a complication of acute parvovirus B19 infection. ( 8963632 )
1996
2
Life-threatening infection in two children with hemoglobin S-beta-thalassemia. ( 7699536 )
1995
3
Risk of infection in children with hemoglobin S-beta-thalassemia. ( 7562304 )
1995
4
Down syndrome complicated by hemoglobin S/beta+ thalassemia. Atypical expression of coexistent disease. ( 2141809 )
1990

Variations for Hemoglobin S Beta-Thalassemia

Expression for Hemoglobin S Beta-Thalassemia

Search GEO for disease gene expression data for Hemoglobin S Beta-Thalassemia.

Pathways for Hemoglobin S Beta-Thalassemia

GO Terms for Hemoglobin S Beta-Thalassemia

Sources for Hemoglobin S Beta-Thalassemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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