MCID: HMG015
MIFTS: 22

Hemoglobin S Beta-Thalassemia malady

Blood diseases category

Summaries for Hemoglobin S Beta-Thalassemia

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32MalaCards
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MalaCards: Hemoglobin S Beta-Thalassemia is related to beta thalassemia and thalassemia. An important gene associated with Hemoglobin S Beta-Thalassemia is HBB (hemoglobin, beta), and among its related pathways are Platelet activation, signaling and aggregation and Factors involved in megakaryocyte development and platelet production. The compounds dimethyl sulfate and benzidine have been mentioned in the context of this disorder.

Aliases & Classifications for Hemoglobin S Beta-Thalassemia

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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Blood diseases


Aliases & Descriptions:

hemoglobin s beta-thalassemia 20


Related Diseases for Hemoglobin S Beta-Thalassemia

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Hemoglobin S Beta-Thalassemia:



Diseases related to hemoglobin s beta-thalassemia

Clinical Features for Hemoglobin S Beta-Thalassemia

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Drugs & Therapeutics for Hemoglobin S Beta-Thalassemia

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Hemoglobin S Beta-Thalassemia

Drug clinical trials:

Search ClinicalTrials for Hemoglobin S Beta-Thalassemia

Search NIH Clinical Center for Hemoglobin S Beta-Thalassemia

Search CenterWatch for Hemoglobin S Beta-Thalassemia

Genetic Tests for Hemoglobin S Beta-Thalassemia

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20GeneTests
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Genetic tests related to Hemoglobin S Beta-Thalassemia:

id Genetic test Affiliating Genes
1 Hemoglobin S Beta-Thalassemia20 HBB

Anatomical Context for Hemoglobin S Beta-Thalassemia

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Animal Models for Hemoglobin S Beta-Thalassemia or affiliated genes

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Publications for Hemoglobin S Beta-Thalassemia

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Genetic Variations for Hemoglobin S Beta-Thalassemia

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Expression for genes affiliated with Hemoglobin S Beta-Thalassemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hemoglobin S Beta-Thalassemia

Search GEO for disease gene expression data for Hemoglobin S Beta-Thalassemia.

Pathways for genes affiliated with Hemoglobin S Beta-Thalassemia

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53Reactome
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Pathways related to Hemoglobin S Beta-Thalassemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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7.6HBG1, HBB, HBE1, HBG2, HBD
27.6HBG2, HBE1, HBB, HBG1, HBD

Compounds for genes affiliated with Hemoglobin S Beta-Thalassemia

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 2BitterDB
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Compounds related to Hemoglobin S Beta-Thalassemia according to GeneCards/GeneDecks:

(show all 37)
idCompoundScoreTop Affiliating Genes
1dimethyl sulfate449.8HBB, HBG1
2benzidine449.8HBB, HBG1
3porphobilinogen44 11 2411.8HBB, HBG1
4propionate449.7HBB, HBG1
55-aminolevulinic acid44 2410.7HBG1, HBB
6neomycin449.6HBB, HBG1
7de-oxy449.6HBG2, HBB
8s-nitrosocysteine449.6HBG2, HBB
98-aminoquinoline449.5HBG2, G6PD
10phenazine methosulfate449.5G6PD, HBG2
11no-dimethylhydroxylamine449.5HBG2, G6PD
12primaquine49 44 1111.5G6PD, HBG2
13scopolamine44 28 11 2412.5G6PD, HBG2
14sulfamethoxazole44 49 1111.5HBG2, G6PD
15methylene449.5HBG2, G6PD
16dapsone2 44 49 1112.5G6PD, HBG2
17tert-butylhydroperoxide449.4G6PD, HBG2
18tocopherol449.4G6PD, HBG2
19gssg449.4G6PD, HBG2
20malondialdehyde449.4HBG2, G6PD
21acetaminophen44 2 49 11 2413.3G6PD, HBG2
22azathioprine44 49 2 1112.3HBB, HBG1, G6PD
23glyceraldehyde 3-phosphate449.3G6PD, HBG1, HBB
24uric acid44 2410.3HBG2, G6PD
25polyethylene glycol449.2G6PD, HBG2
2623-diphosphoglycerate449.1G6PD, HBB, HBG2
27vitamin-e449.1HBG2, G6PD
28sodium nitroprusside449.1HBG2, G6PD
29glucose 6-phosphate44 2410.1G6PD, HBB, HBG2
30n-ethylmaleimide44 1110.0G6PD, HBG2
31hydroxyurea44 49 1111.0HBG1, HBB, HBG2
32lactate449.0G6PD, HBB, HBG2
33iron44 249.9HBG2, HBB, HBG1
34h2o2448.8G6PD, HBB, HBG2
35alpha tocopherol448.8HBG2, G6PD
36heme28 11 2410.1HBG2, HBE1, HBB, HBG1, HBD
37oxygen44 249.0G6PD, HBD, HBG1, HBB, HBG2

GO Terms for genes affiliated with Hemoglobin S Beta-Thalassemia

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16Gene Ontology
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Cellular components related to Hemoglobin S Beta-Thalassemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hemoglobin complexGO:0058337.3HBG2, HBE1, HBB, HBG1, HBD
2cytosolGO:0058297.1HBD, HBG1, HBB, HBE1, HBG2, G6PD

Biological processes related to Hemoglobin S Beta-Thalassemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood coagulationGO:0075967.6HBG2, HBE1, HBB, HBG1, HBD

Molecular functions related to Hemoglobin S Beta-Thalassemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1oxygen transporter activityGO:0053447.6HBG2, HBE1, HBB, HBG1, HBD
2iron ion bindingGO:0055067.6HBG2, HBE1, HBB, HBG1, HBD
3oxygen bindingGO:0198257.5HBD, HBG1, HBB, HBE1, HBG2
4heme bindingGO:0200377.3HBD, HBG1, HBB, HBE1, HBG2

Products for genes affiliated with Hemoglobin S Beta-Thalassemia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hemoglobin S Beta-Thalassemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet