MCID: HMG015
MIFTS: 14

Hemoglobin S Beta-Thalassemia malady

Categories: Genetic diseases, Blood diseases

Aliases & Classifications for Hemoglobin S Beta-Thalassemia

Aliases & Descriptions for Hemoglobin S Beta-Thalassemia:

Name: Hemoglobin S Beta-Thalassemia 24
Sickle Cell-Beta-Thalassemia 69

Classifications:



Summaries for Hemoglobin S Beta-Thalassemia

MalaCards based summary : Hemoglobin S Beta-Thalassemia, also known as sickle cell-beta-thalassemia, is related to thalassemia and down syndrome. An important gene associated with Hemoglobin S Beta-Thalassemia is HBB (Hemoglobin Subunit Beta). The drugs Hydroxyurea and Epoetin alfa have been mentioned in the context of this disorder.

Related Diseases for Hemoglobin S Beta-Thalassemia

Diseases related to Hemoglobin S Beta-Thalassemia via text searches within MalaCards or GeneCards Suite gene sharing:

id Related Disease Score Top Affiliating Genes
1 thalassemia 10.2
2 down syndrome 9.9

Symptoms & Phenotypes for Hemoglobin S Beta-Thalassemia

Drugs & Therapeutics for Hemoglobin S Beta-Thalassemia

Drugs for Hemoglobin S Beta-Thalassemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 72)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hydroxyurea Approved Phase 2, Phase 3,Phase 1 127-07-1 3657
2 Epoetin alfa Phase 2, Phase 3 113427-24-0
3 Hematinics Phase 2, Phase 3
4 Nucleic Acid Synthesis Inhibitors Phase 2, Phase 3,Phase 1
5
Nitric Oxide Approved Phase 2,Phase 1 10102-43-9 145068
6
Tacrolimus Approved, Investigational Phase 1, Phase 2 104987-11-3 445643 439492
7
Melphalan Approved Phase 1, Phase 2 148-82-3 4053 460612
8
Cyclophosphamide Approved, Investigational Phase 1, Phase 2 50-18-0, 6055-19-2 2907
9
Fludarabine Approved Phase 1, Phase 2 21679-14-1, 75607-67-9 30751
10
Busulfan Approved, Investigational Phase 1, Phase 2 55-98-1 2478
11
Prednisolone Approved, Vet_approved Phase 1, Phase 2 50-24-8 5755
12
Miconazole Approved, Investigational, Vet_approved Phase 1, Phase 2 22916-47-8 4189
13
alemtuzumab Approved, Investigational Phase 1, Phase 2 216503-57-0
14
Everolimus Approved Phase 1, Phase 2 159351-69-6 6442177
15
Thiotepa Approved Phase 1, Phase 2 52-24-4 5453
16
Methylprednisolone Approved, Vet_approved Phase 1, Phase 2 83-43-2 6741
17
Sirolimus Approved, Investigational Phase 1, Phase 2 53123-88-9 5284616 6436030 46835353
18 Gastrointestinal Agents Phase 1, Phase 2
19 Neurotransmitter Agents Phase 2,Phase 1
20 Peripheral Nervous System Agents Phase 2,Phase 1
21 Vasodilator Agents Phase 2,Phase 1
22 Endothelium-Dependent Relaxing Factors Phase 2,Phase 1
23 Anti-Asthmatic Agents Phase 2,Phase 1
24 Anti-Infective Agents Phase 1, Phase 2
25 Protective Agents Phase 2,Phase 1
26 Liver Extracts Phase 1, Phase 2
27 Respiratory System Agents Phase 2,Phase 1
28 Autonomic Agents Phase 2,Phase 1
29 Bronchodilator Agents Phase 2,Phase 1
30 Antioxidants Phase 2,Phase 1
31 Prednisolone acetate Phase 1, Phase 2
32 Alkylating Agents Phase 1, Phase 2
33 glucocorticoids Phase 1, Phase 2
34 Neuroprotective Agents Phase 1, Phase 2
35 Hormone Antagonists Phase 1, Phase 2
36 Hormones Phase 1, Phase 2
37 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1, Phase 2
38 Pharmaceutical Solutions Phase 1, Phase 2
39 Anti-Bacterial Agents Phase 1, Phase 2
40 Prednisolone hemisuccinate Phase 1, Phase 2
41 Prednisolone phosphate Phase 1, Phase 2
42 Immunosuppressive Agents Phase 1, Phase 2
43 Antiemetics Phase 1, Phase 2
44 Anti-Inflammatory Agents Phase 1, Phase 2
45 Antifungal Agents Phase 1, Phase 2
46 Antimetabolites Phase 1, Phase 2
47 Antibiotics, Antitubercular Phase 1, Phase 2
48 Antimetabolites, Antineoplastic Phase 1, Phase 2
49 Methylprednisolone acetate Phase 1, Phase 2
50 Methylprednisolone Hemisuccinate Phase 1, Phase 2

Interventional clinical trials:

(show all 25)
id Name Status NCT ID Phase
1 Therapeutic Effect and Safety of Combined Hydroxyurea With Recombinant Human Erythropoietin. Unknown status NCT01624038 Phase 2, Phase 3
2 Study to Evaluate Efficacy and Safety of S303 Treated Red Blood Cells (RBCs)in Subjects With Thalassemia Major Requiring Chronic RBC Transfusion Active, not recruiting NCT01740531 Phase 3
3 Nitric Oxide Inhalation to Treat Sickle Cell Pain Crises Completed NCT00094887 Phase 2
4 Study to Evaluate the Effects of ACE-536 in Patients With Beta-thalassemia Completed NCT01749540 Phase 2
5 CD34+ (Malignant) Stem Cell Selection for Patients Receiving Allogenic Stem Cell Transplant Recruiting NCT02061800 Phase 1, Phase 2
6 Nonmyeloablative Haploidentical Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Severe Congenital Anemias Including Sickle Cell Disease and Beta-Thalassemia Active, not recruiting NCT00977691 Phase 1, Phase 2
7 Phase I/II Pilot Study of Mixed Chimerism to Treat Hemoglobinopathies Suspended NCT01419704 Phase 1, Phase 2
8 Evaluation of Hydroxyurea Plus L-arginine or Sildenafil to Treat Sickle Cell Anemia Completed NCT00056433 Phase 1
9 Therapeutic Application of Intravascular Nitrite for Sickle Cell Disease Completed NCT00095472 Phase 1
10 Haploidentical Hematopoietic Stem Cell Transplantation for Children With Sickle Cell Disease and Thalassemia Using CD34+ Positive Selected Grafts Recruiting NCT02165007 Phase 1
11 The Role of Endothelin-1 in Sickle Cell Disease Recruiting NCT02712346 Phase 1
12 Study of Panobinostat (LBH589) in Patients With Sickle Cell Disease Recruiting NCT01245179 Phase 1
13 The Spleen in Sickle Cell Anemia and Sickle Cell Thalassemia Completed NCT00971698
14 Clinical and Laboratory Assessment of Iron Overload in Sickle Cell Anemia and Sickle Cell Thalassemia Completed NCT00512564
15 Iron Overload Assesment in Sickle Cell Anemia and Sickle Cell Thalassemia Completed NCT00512226
16 MRI Evaluation of Iron Overload in the Heart, Liver and Pancreas in Patients Receiving Multiple Blood Transfusions. Completed NCT00629291
17 Clinical and Laboratory Characteristics of Sickle Cell Anemia Patients Admitted With Fever Completed NCT00736060
18 Long Term Follow up in Sickle Cell Patients Treated by Hydroxyurea Completed NCT00480974
19 Iron Overload and Growth Velocity in Thalassemia and Sickle Cell Anemia Completed NCT00972231
20 Sickle Cell Anemia in an Arab Bedouin Village in the Northern Israel Completed NCT00481039
21 Hepcidin Levels in Sickle Cell Disease (SCD) Completed NCT02258997
22 Perceptions of Thalassemia Major in Singapore: An Exploratory Study of Stigma Completed NCT01129076
23 CD34+ Stem Cell Selection for Patients Receiving Allogeneic Stem Cell Transplantation for Non-Malignant Disease Recruiting NCT01966367
24 Sickle Cell Anemia - A Comparative Study Between Three Ethnical Communities, a Multicenter Study Recruiting NCT01905787
25 Bone Marrow Transplantation, Hemoglobinopathies, SCALLOP Terminated NCT00578344

Search NIH Clinical Center for Hemoglobin S Beta-Thalassemia

Genetic Tests for Hemoglobin S Beta-Thalassemia

Genetic tests related to Hemoglobin S Beta-Thalassemia:

id Genetic test Affiliating Genes
1 Hemoglobin S Beta-Thalassemia 24 HBB

Anatomical Context for Hemoglobin S Beta-Thalassemia

Publications for Hemoglobin S Beta-Thalassemia

Articles related to Hemoglobin S Beta-Thalassemia:

id Title Authors Year
1
Fatal fat embolism syndrome in a child with undiagnosed hemoglobin S/beta+ thalassemia: a complication of acute parvovirus B19 infection. ( 8963632 )
1996
2
Life-threatening infection in two children with hemoglobin S-beta-thalassemia. ( 7699536 )
1995
3
Risk of infection in children with hemoglobin S-beta-thalassemia. ( 7562304 )
1995
4
Down syndrome complicated by hemoglobin S/beta+ thalassemia. Atypical expression of coexistent disease. ( 2141809 )
1990

Variations for Hemoglobin S Beta-Thalassemia

Expression for Hemoglobin S Beta-Thalassemia

Search GEO for disease gene expression data for Hemoglobin S Beta-Thalassemia.

Pathways for Hemoglobin S Beta-Thalassemia

GO Terms for Hemoglobin S Beta-Thalassemia

Sources for Hemoglobin S Beta-Thalassemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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