MCID: HMG017
MIFTS: 21

Hemoglobin So malady

Blood category

Summaries for Hemoglobin So

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33MalaCards
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MalaCards: Hemoglobin So is related to thalassemia and malaria. An important gene associated with Hemoglobin So is HBB (hemoglobin, beta), and among its related pathways are Platelet activation, signaling and aggregation and Factors involved in megakaryocyte development and platelet production. The compounds oxygen and heme have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and spleen.

Aliases & Classifications for Hemoglobin So

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20GeneTests
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Blood


Aliases & Descriptions:

hemoglobin so 20


Related Diseases for Hemoglobin So

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Hemoglobin So via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1thalassemia30.0HBB, HBD
2malaria10.0HBB
3sickle cell anemia10.0HBB, HBD
4sickle cell disease10.0HBB, HBD
5deficiency anemia10.0HBB, HBD

Graphical network of diseases related to Hemoglobin So:



Diseases related to hemoglobin so

Clinical Features for Hemoglobin So

Drugs & Therapeutics for Hemoglobin So

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Hemoglobin So

Drug clinical trials:

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Search NIH Clinical Center for Hemoglobin So

Search CenterWatch for Hemoglobin So

Genetic Tests for Hemoglobin So

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20GeneTests
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Genetic tests related to Hemoglobin So:

id Genetic test Affiliating Genes
1 Hemoglobin So20 HBB

Anatomical Context for Hemoglobin So

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33MalaCards
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MalaCards organs/tissues related to Hemoglobin So:

33
Bone marrow, Whole blood, Spleen, Lung, Monocytes, B cells, Endothelial, Fetal lung

Animal Models for Hemoglobin So or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Hemoglobin So

Sources:
51PubMed
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Articles related to Hemoglobin So:

(show top 50)    (show all 91)
idTitleAuthorsYear
1
Gigantic splenomegaly in a 27-year-old male of South-East Asian descent with concurrent diagnosis of myeloproliferative neoplasm and hemoglobin H disease. (23672282)
2013
2
A Newly Modified Hemoglobin H Inclusion Test as a Secondary Screening for I+-Thalassemia in Southeast Asian Populations. (24356175)
2013
3
Low fetal hemoglobin rates in patients carrying Thai (I'I^)0-deletion and Turkish (I'I^)0-deletion/inversion strengthen the hypothesis that the 5'I' BCL11A binding site plays a major role in its fetal hemoglobin inhibitory regulation. Response to "The 12.6 kb-deletion in the I^-globin gene cluster is the known Thai/Vietnamese (I'I^)0-thalassemia commonly found in Southeast Asia". (24006413)
2013
4
A case of paroxysmal nocturnal hemoglobinuria caused by a germline mutation and a somatic mutation in PIGT. (23733340)
2013
5
Diagnostic value of serum concentrations of high-mobility group-box protein 1 and soluble hemoglobin scavenger receptor in brucellosis. (23278480)
2013
6
The phenotype of a germline mutation in PIGA: the gene somatically mutated in paroxysmal nocturnal hemoglobinuria. (22305531)
2012
7
Umbilical cord blood concentration of soluble scavenger receptor for hemoglobin, but not pentraxin 3, is of value for the early postpartum identification of the presence of histological chorioamnionitis. (21933102)
2011
8
Combined I+-thalassemia and Hemoglobin J-Iran (I^77 His a89 Asp). A Family Study in southern Iran. (22737531)
2011
9
The influence of socioeconomic status on the hemoglobin level and anthropometry of sickle cell anemia patients in steady state at the Lagos University Teaching Hospital. (22248942)
2011
10
Amniotic fluid concentrations of soluble scavenger receptor for hemoglobin (sCD163) in pregnancy complicated by preterm premature rupture of the membranes and histologic chorioamnionitis. (21158489)
2011
11
Increased soluble urokinase plasminogen activator receptor (suPAR) is associated with thrombosis and inhibition of plasmin generation in paroxysmal nocturnal hemoglobinuria (PNH) patients. (18954937)
2008
12
FDA report: eculizumab (Soliris) for the treatment of patients with paroxysmal nocturnal hemoglobinuria. (18784156)
2008
13
Hemoglobinopathies and glucose-6-phosphate dehydrogenase deficiency in the sub-Saharan immigrant population of the Center and South Maresme region, Catalonia, Spain]. (18582416)
2008
14
Rheological properties of hemoglobin vesicles (artificial oxygen carriers) suspended in a series of plasma-substitute solutions. (17567054)
2007
15
Metastable mesoscopic clusters in solutions of sickle-cell hemoglobin. (17040989)
2007
16
Paroxysmal nocturnal hemoglobinuria: an acquired X-linked genetic disease with somatic-cell mosaicism. (16650759)
2006
17
Molecular mechanism of high hemoglobin F production in Southeast Asian-type hereditary persistence of fetal hemoglobin. (16720553)
2006
18
High-yield expression in Escherichia coli of soluble human alpha-hemoglobin complexed with its molecular chaperone. (16390839)
2006
19
Soluble transferrin receptors and reticulocyte hemoglobin concentration in the assessment of iron deficiency in hemodialysis patients. (15772926)
2005
20
Soluble hemoglobin-haptoglobin scavenger receptor CD163 as a lineage-specific marker in the reactive hemophagocytic syndrome. (15613100)
2005
21
Mutual effects of proton and sodium chloride on oxygenation of liganded human hemoglobin. (16302974)
2005
22
Hemoglobin mediated nitrite activation of soluble guanylyl cyclase. (15936233)
2005
23
Reductive nitrosylation and S-nitrosation of hemoglobin in inhomogeneous nitric oxide solutions. (15135360)
2004
24
Adsorption behavior of cytochrome c, myoglobin and hemoglobin in a quartz surface probed using slab optical waveguide (SOWG) spectroscopy. (12608745)
2003
25
Quaternary structure of hemoglobin in solution. (12525687)
2003
26
Influence of sickle hemoglobinopathy on growth and development of young adult males in Southern Iraq. (12847636)
2003
27
Hydroxyurea induces fetal hemoglobin by the nitric oxide-dependent activation of soluble guanylyl cyclase. (12531879)
2003
28
Detection of somatic mutations of the PIG-A gene in Brazilian patients with paroxysmal nocturnal hemoglobinuria. (11378665)
2001
29
Parameters of interaction of sodium dodecyl sulfate with human hemoglobin]. (11094702)
2000
30
Genetic instability and the etiology of somatic PIG-A mutations in paroxysmal nocturnal hemoglobinuria. (10389589)
1999
31
Hemoglobin based oxygen carrying solution stability in extracorporeal circulation: an in vitro evaluation and implications for clinical use. (9617945)
1998
32
Hemoglobin switching protocols in thalassemia. Experience with sodium phenylbutyrate and hydroxyurea. (9668530)
1998
33
Somatic mutation and clonal selection in the pathogenesis and in the control of paroxysmal nocturnal hemoglobinuria. (9565157)
1998
34
The spectrum of somatic mutations in the PIG-A gene in paroxysmal nocturnal hemoglobinuria includes large deletions and small duplications. (10087994)
1998
35
Modified hemoglobin solution, with desired pharmacological properties, does not activate nuclear transcription factor NF-kappa B in human vascular endothelial cells. (9083639)
1997
36
Effects of partial blood replacement with pyridoxalated hemoglobin polyoxyethylene conjugate solution on transient cerebral ischemia in gerbil. (9083631)
1997
37
Somatic mutation in paroxysmal nocturnal hemoglobinuria. (9307598)
1997
38
Somatic mutations of the PIG-A gene found in Japanese patients with paroxysmal nocturnal hemoglobinuria. (7531514)
1995
39
The PIG-A gene somatic mutation responsible for paroxysmal nocturnal hemoglobinuria. (8647522)
1995
40
Oxygenation of the rat 9L gliosarcoma and the rat 13672 mammary carcinoma with various doses of a hemoglobin solution. (7994406)
1994
41
Glutathione oxidation under the action of sodium nitrite on hemoglobin. (7620520)
1994
42
Reaction of human endothelial cells to bovine hemoglobin solutions and tumor necrosis factor. (7994400)
1994
43
Deficiency of the GPI anchor caused by a somatic mutation of the PIG- A gene in paroxysmal nocturnal hemoglobinuria. (8500164)
1993
44
Hemoglobin E: a common hemoglobinopathy among children of Southeast Asian origin. (3594333)
1987
45
The first homozygote for the hereditary persistence of fetal hemoglobin observed in the southeastern United States. (6166591)
1981
46
False-positive solubility--turbidity test for sickling hemoglobin in a case of congenital syphilis. (7353299)
1980
47
Delineation of peripheral bone infarcts in a child with a rare hemoglobinopathy (SOArab) and purpura fulminans: case report. (186569)
1976
48
AN INVESTIGATION OF ABNORMAL HEMOGLOBINS IN SOUTHERN JAPAN. 2. SECOND CASE OF THALASSEMIA MINOR DISCOVERED IN FUKUOKA, KYUSHU, JAPAN. (14236253)
1964
49
Blood transfusion studies; the relationship of hemoglobinemia and of the pH of the urine to renal damage produced by injection of hemoglobin solutions into dogs. (20289794)
1947
50
STUDIES OF HEMOGLOBINEMIA AND HEMOGLOBINURIA PRODUCED IN MAN BY INTRAVENOUS INJECTION OF HEMOGLOBIN SOLUTIONS. (16694823)
1941

Genetic Variations for Hemoglobin So

Expression for genes affiliated with Hemoglobin So

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hemoglobin So

Search GEO for disease gene expression data for Hemoglobin So.

Pathways for genes affiliated with Hemoglobin So

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54Reactome
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Pathways related to Hemoglobin So according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.1HBB, HBD
29.1HBB, HBD

Compounds for genes affiliated with Hemoglobin So

Sources:
45Novoseek, 24HMDB, 29IUPHAR, 11DrugBank
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Compounds related to Hemoglobin So according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1oxygen45 2410.1HBB, HBD
2heme29 11 2410.8HBB, HBD

GO Terms for genes affiliated with Hemoglobin So

Sources:
16Gene Ontology
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Cellular components related to Hemoglobin So according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hemoglobin complexGO:0058339.1HBB, HBD

Biological processes related to Hemoglobin So according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood coagulationGO:0075969.1HBB, HBD

Molecular functions related to Hemoglobin So according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1oxygen transporter activityGO:0053449.1HBB, HBD
2iron ion bindingGO:0055069.1HBB, HBD
3oxygen bindingGO:0198259.0HBB, HBD
4heme bindingGO:0200378.8HBB, HBD

Products for genes affiliated with Hemoglobin So

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hemoglobin So

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet