MCID: HMG018
MIFTS: 16

Hemoglobin Ss malady

Blood category

Summaries for Hemoglobin Ss

Sources:
33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MalaCards: Hemoglobin Ss, also known as anemia, sickle cell, is related to sickle cell disease and sickle cell anemia. An important gene associated with Hemoglobin Ss is HBB (hemoglobin, beta), and among its related pathways are Platelet activation, signaling and aggregation and Factors involved in megakaryocyte development and platelet production. The drug sodium phenylbutyrate and the compounds oxygen and heme have been mentioned in the context of this disorder.

Aliases & Classifications for Hemoglobin Ss

Sources:
20GeneTests, 61UMLS
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Blood


Aliases & Descriptions:

hemoglobin ss 20
anemia, sickle cell 61


Related Diseases for Hemoglobin Ss

Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Hemoglobin Ss:



Diseases related to hemoglobin ss

Clinical Features for Hemoglobin Ss

Drugs & Therapeutics for Hemoglobin Ss

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Hemoglobin Ss

Drug clinical trials:

Search ClinicalTrials for Hemoglobin Ss

Search NIH Clinical Center for Hemoglobin Ss

Search CenterWatch for Hemoglobin Ss

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Hemoglobin Ss

Sources:
20GeneTests
See all sources

Genetic tests related to Hemoglobin Ss:

id Genetic test Affiliating Genes
1 Hemoglobin Ss20 HBB

Anatomical Context for Hemoglobin Ss

Animal Models for Hemoglobin Ss or affiliated genes

Sources:
28inGenious Targeting Laboratory
See all sources

Publications for Hemoglobin Ss

Genetic Variations for Hemoglobin Ss

Expression for genes affiliated with Hemoglobin Ss

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Hemoglobin Ss

Search GEO for disease gene expression data for Hemoglobin Ss.

Pathways for genes affiliated with Hemoglobin Ss

Sources:
54Reactome
See all sources

Pathways related to Hemoglobin Ss according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.1HBB, HBD
29.1HBB, HBD

Compounds for genes affiliated with Hemoglobin Ss

Sources:
45Novoseek, 24HMDB, 29IUPHAR, 11DrugBank
See all sources

Compounds related to Hemoglobin Ss according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1oxygen45 2410.1HBB, HBD
2heme29 11 2410.8HBB, HBD

GO Terms for genes affiliated with Hemoglobin Ss

Sources:
16Gene Ontology
See all sources

Cellular components related to Hemoglobin Ss according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hemoglobin complexGO:0058339.1HBB, HBD

Biological processes related to Hemoglobin Ss according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood coagulationGO:0075969.1HBB, HBD

Molecular functions related to Hemoglobin Ss according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1oxygen transporter activityGO:0053449.1HBB, HBD
2iron ion bindingGO:0055069.1HBB, HBD
3oxygen bindingGO:0198259.0HBB, HBD
4heme bindingGO:0200378.8HBB, HBD

Products for genes affiliated with Hemoglobin Ss

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hemoglobin Ss

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet