MCID: HMG018
MIFTS: 19

Hemoglobin Ss malady

Genetic diseases, Blood diseases, Rare diseases categories
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Summaries for Hemoglobin Ss

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33MalaCards
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MalaCards: Hemoglobin Ss, also known as anemia, sickle cell, is related to sickle cell disease and acute chest syndrome. An important gene associated with Hemoglobin Ss is HBB (hemoglobin, beta). The drug sodium phenylbutyrate has been mentioned in the context of this disorder.

Aliases & Classifications for Hemoglobin Ss

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20GeneTests, 62UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Blood diseases


Aliases & Descriptions:

hemoglobin ss 20
anemia, sickle cell 62


Related Diseases for Hemoglobin Ss

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17GeneCards, 18GeneDecks
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Diseases in the Hemoglobin E Disease family:

Hemoglobin C Disease Hemoglobin D Disease
Hemoglobin Sd hemoglobin ss
Hemoglobin So

Diseases related to Hemoglobin Ss via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1sickle cell disease10.4
2acute chest syndrome10.1
3sickle cell anemia10.1
4septic arthritis10.1
5arthritis10.1
6hemoglobinopathy10.1
7retinitis10.1

Graphical network of diseases related to Hemoglobin Ss:



Diseases related to hemoglobin ss

Symptoms for Hemoglobin Ss

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Drugs & Therapeutics for Hemoglobin Ss

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Hemoglobin Ss

Search NIH Clinical Center for Hemoglobin Ss

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Hemoglobin Ss

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20GeneTests
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Genetic tests related to Hemoglobin Ss:

id Genetic test Affiliating Genes
1 Hemoglobin Ss20 HBB

Anatomical Context for Hemoglobin Ss

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Animal Models for Hemoglobin Ss or affiliated genes

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Publications for Hemoglobin Ss

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52PubMed
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Articles related to Hemoglobin Ss:

(show all 16)
idTitleAuthorsYear
1
Human bulbar conjunctival hemodynamics in hemoglobin SS and SC disease. (23657867)
2013
2
Sickle Cell Disease: quality of life in patients with hemoglobin SS and SC disorders. (24255615)
2013
3
Relationship between acute chest syndrome and the sympatho-vagal balance in adults with hemoglobin SS disease; a case control study. (22460267)
2013
4
Native joint septic arthritis caused by Clostridium difficile in an 11-year old with hemoglobin SS disease. (19710591)
2009
5
Cognitive impairment in children with hemoglobin SS sickle cell disease: relationship to MR imaging findings and hematocrit. (12637286)
2003
6
Bilateral simultaneous retinal arteriolar obstruction in a child with hemoglobin SS sickle cell disease. (11304823)
2001
7
Laboratory recognition of a rare hemoglobinopathy: hemoglobins SS and SG(Philadelphia) associated with alpha-thalassemia-2. (10506456)
1999
8
Case 2--1996. Anesthetic management of a patient with hemoglobin SS disease and mitral insufficiency for mitral valve repair. (8725428)
1996
9
Hematologic profile and lymphocyte subpopulations in hemoglobin SC disease: comparison with hemoglobin SS and black controls. The Transfusion Safety Study Group. (8756079)
1996
10
Rate of activation and deactivation of K:Cl cotransport by changes in cell volume in hemoglobin SS, CC and AA red cells. (7707362)
1994
11
Variable degrees of suppression of hemoglobin S synthesis in subjects with hemoglobin SS disease on a long-term transfusion regimen. (8301425)
1994
12
The glomerulopathy of homozygous sickle hemoglobin (SS) disease: morphology and pathogenesis. (1932637)
1991
13
Serial evaluation of iron stores in pregnant Nigerians with hemoglobin SS or SC. (2304096)
1990
14
Intravascular volume expansion and fetal outcome in pregnant Nigerians with hemoglobin SS and SC. (3246704)
1988
15
The leftward deletion alpha-thal-2 haplotype in a black subject with hemoglobin SS. (3971048)
1985
16
Restriction of heterogeneity of goat antibodies specific for human hemoglobin SS. (803525)
1975

Variations for Hemoglobin Ss

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Expression for genes affiliated with Hemoglobin Ss

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hemoglobin Ss

Search GEO for disease gene expression data for Hemoglobin Ss.

Pathways for genes affiliated with Hemoglobin Ss

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Compounds for genes affiliated with Hemoglobin Ss

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GO Terms for genes affiliated with Hemoglobin Ss

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Products for genes affiliated with Hemoglobin Ss

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hemoglobin Ss

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet