MCID: HMG018
MIFTS: 18

Hemoglobin Ss malady

Blood diseases category

Summaries for Hemoglobin Ss

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32MalaCards
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MalaCards: Hemoglobin Ss, also known as anemia, sickle cell, is related to sickle cell disease and sickle cell anemia. An important gene associated with Hemoglobin Ss is HBB (hemoglobin, beta), and among its related pathways are Platelet activation, signaling and aggregation and Factors involved in megakaryocyte development and platelet production. The drug sodium phenylbutyrate and the compounds oxygen and heme have been mentioned in the context of this disorder.

Aliases & Classifications for Hemoglobin Ss

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Sources:
20GeneTests, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Blood diseases


Aliases & Descriptions:

hemoglobin ss 20
anemia, sickle cell 60


Related Diseases for Hemoglobin Ss

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17GeneCards, 18GeneDecks
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Graphical network of diseases related to Hemoglobin Ss:



Diseases related to hemoglobin ss

Clinical Features for Hemoglobin Ss

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Drugs & Therapeutics for Hemoglobin Ss

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Hemoglobin Ss

Drug clinical trials:

Search ClinicalTrials for Hemoglobin Ss

Search NIH Clinical Center for Hemoglobin Ss

Search CenterWatch for Hemoglobin Ss

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Hemoglobin Ss

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20GeneTests
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Genetic tests related to Hemoglobin Ss:

id Genetic test Affiliating Genes
1 Hemoglobin Ss20 HBB

Anatomical Context for Hemoglobin Ss

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Animal Models for Hemoglobin Ss or affiliated genes

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Publications for Hemoglobin Ss

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Genetic Variations for Hemoglobin Ss

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Expression for genes affiliated with Hemoglobin Ss

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hemoglobin Ss

Search GEO for disease gene expression data for Hemoglobin Ss.

Pathways for genes affiliated with Hemoglobin Ss

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53Reactome
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Pathways related to Hemoglobin Ss according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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9.1HBB, HBD
29.1HBB, HBD

Compounds for genes affiliated with Hemoglobin Ss

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Sources:
44Novoseek, 24HMDB, 28IUPHAR, 11DrugBank
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Compounds related to Hemoglobin Ss according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1oxygen44 2410.1HBB, HBD
2heme28 11 2410.8HBB, HBD

GO Terms for genes affiliated with Hemoglobin Ss

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Sources:
16Gene Ontology
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Cellular components related to Hemoglobin Ss according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hemoglobin complexGO:0058339.1HBB, HBD

Biological processes related to Hemoglobin Ss according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood coagulationGO:0075969.1HBB, HBD

Molecular functions related to Hemoglobin Ss according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1oxygen transporter activityGO:0053449.1HBB, HBD
2iron ion bindingGO:0055069.1HBB, HBD
3oxygen bindingGO:0198259.0HBB, HBD
4heme bindingGO:0200378.8HBB, HBD

Products for genes affiliated with Hemoglobin Ss

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hemoglobin Ss

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet