MCID: HMG010
MIFTS: 39

Hemoglobinemia malady

Rare diseases, Blood diseases categories
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Summaries for Hemoglobinemia

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Wikipedia:65 Hemoglobinemia (British Haemoglobinaemia) is a medical condition in which there is an excess of... more...

MalaCards based summary: Hemoglobinemia, also known as haemoglobinaemia, is related to hemolytic anemia and hemoglobinuria. An important gene associated with Hemoglobinemia is HP (haptoglobin), and among its related pathways is Binding and Uptake of Ligands by Scavenger Receptors. The compounds cellulose acetate and vitamin b12 have been mentioned in the context of this disorder. Affiliated tissues include kidney, prostate and spleen, and related mouse phenotypes are liver/biliary system and immune system.

Aliases & Classifications for Hemoglobinemia

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Sources:
42NIH Rare Diseases, 44Novoseek, 62UMLS
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Hemoglobinemia, Aliases & Descriptions:

Name: Hemoglobinemia 42 44 62
Haemoglobinaemia 62
 
Haemoglobinemia 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Blood diseases


Related Diseases for Hemoglobinemia

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Graphical network of the top 20 diseases related to Hemoglobinemia:



Diseases related to hemoglobinemia

Symptoms for Hemoglobinemia

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Drugs & Therapeutics for Hemoglobinemia

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Drug clinical trials:

Search ClinicalTrials for Hemoglobinemia

Search NIH Clinical Center for Hemoglobinemia

Genetic Tests for Hemoglobinemia

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Anatomical Context for Hemoglobinemia

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MalaCards organs/tissues related to Hemoglobinemia:

32
Kidney, Prostate, Spleen, Skin

Animal Models for Hemoglobinemia or affiliated genes

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MGI Mouse Phenotypes related to Hemoglobinemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.5HP, HBB, B2M
2MP:00053878.5HP, HBB, B2M
3MP:00053858.4HP, HBB, B2M
4MP:00053978.2B2M, HBB, HP

Publications for Hemoglobinemia

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Articles related to Hemoglobinemia:

(show all 49)
idTitleAuthorsYear
1
Aurin tricarboxylic acid protects against red blood cell hemolysis in patients with paroxysmal nocturnal hemoglobinemia. (24489894)
2014
2
Renal impairment, hemoglobinuria, and hemoglobinemia among patients with idiopathic thrombocytopenic purpura. (21786287)
2011
3
Postoperative acute kidney injury is associated with hemoglobinemia and an enhanced oxidative stress response. (21334433)
2011
4
Disseminated intravascular coagulation associated with acute hemoglobinemia or hemoglobinuria following Rh(0)(D) immune globulin intravenous administration for immune thrombocytopenic purpura. (15878975)
2005
5
Unstable hemoglobinemia, Hb Buenos Aires, Bryn Mawr, followed up for eighteen years. (15717496)
2004
6
Acute onset hemoglobinemia and/or hemoglobinuria and sequelae following Rh(o)(D) immune globulin intravenous administration in immune thrombocytopenic purpura patients. (10753830)
2000
7
Hypophysectomy, high tumor necrosis factor levels, and hemoglobinemia in lethal endotoxemic shock. (9872677)
1998
8
Hemoglobinemia and hemoglobinuria complicating concomitant use of a white cell filter and a pressure infusion device. (7825215)
1995
9
Bovine postparturient hemoglobinemia: hypophosphatemia and metabolic disorder in red blood cells. (3631722)
1987
10
Hemoglobinemia and renal failure from an intracerebral hematoma simulating a vein of Galen aneurysm. (3614590)
1987
11
An immediate hemolytic transfusion reaction due to anti-C and a delayed hemolytic transfusion reaction due to anti-Ce+e: hemoglobinemia, hemoglobinuria and transient impaired renal function. (6438912)
1984
12
Hypoxia-induced hemoglobinemia: hypoxic threshold and pathogenic mechanism. (7461040)
1980
13
Hemoglobinemia in rats exposed to high altitude is not due to an overload of catabolic mechanisms. (420674)
1979
14
Hemoglobinemia in mice exposed to high altitude. (572040)
1979
15
The experimental study on the mechanism of hemolysis on paroxysmal hemoglobinemia and hemoglobinuria in calves due to excessive water intake. (522335)
1979
16
Hemoglobinemia in rats exposed to high altitude. (658174)
1978
17
Letter: Coagulation studies during experimental hemoglobinemia. (989124)
1976
18
Coagulation changes in baboons during acute experimental hemoglobinemia and dextran infusion. (804256)
1975
19
Hemoglobinemia in heroin overdose patients. (1212878)
1975
20
Coagulation studies during experimental hemoglobinemia in humans. (1120740)
1975
21
Coagulation studies and correlative histology during experimental hemoglobinemia in rabbits. (4814901)
1974
22
Autoimmune hemolytic anemia with hemoglobinemia and hemoglobinuria in the absence of a demonstrable hemolysin or complement-binding antibody. (5766098)
1969
23
The effects of acut intravascular hemolysis on coagulation and fibrinolysis. II. March hemoglobinemia and hemoglobinuria. (5670600)
1968
24
Autoradiographic demonstration of hemoglobin in lysosomes of rabbit proximal tubule cells during experimental hemoglobinemia. (5715761)
1968
25
The effects of acute intravascular hemolysis on coagulation and fibrinolysis. 3. Hemoglobinemia casused by ingestion of strong acids. (5670601)
1968
26
The renal lesion associated with hemoglobinemia: a study of the pathogenesis of the excretory defect in the rat. (6023773)
1967
27
The renal lesion associated with hemoglobinemia. I. Its production and functional evolution in the rat. (5937060)
1966
28
The renal lesion associated with hemoglobinemia. II. Its structural characteristics in the rat. (5937061)
1966
29
CONTROLLER-GENE DISEASES: THE OPERON MODEL AS APPLIED TO BETA-THALASSEMIA, FAMILIAL FETAL HEMOGLOBINEMIA AND THE NORMAL SWITCH FROM THE PRODUCTION OF FETAL HEMOGLOBIN TO THAT OF ADULT HEMOGLOBIN. (14149956)
1964
30
The renal excretion of hemoglobin in sickle cell anemia, with observations on spontaneously occurring hemoglobinemia and methemalbuminemia. (14462673)
1962
31
Fetomaternal ABO incompatibility: intravascular hemolysis, fetal hemoglobinemia, and fibrinogenopenia in maternal circulation. (13745908)
1961
32
The role of acid hematin in the development of acute renal failure following hemoglobinemia. (13762779)
1961
33
Experimental studies in hemoglobinuric nephrosis. II. The enhanced effect on the kidneys of glycerol-induced hemoglobinemia combined with unilateral nephrectomy. (13669985)
1959
34
Experimental studies in hemoglobinuric nephrosis. Part 3. The effect of acute hemolytic anemia (hemoglobinemia) combined with ten minutes' unilateral renal ischemia on the morphology and function of the rabbit's kidneys. (13821371)
1959
35
Studies on the serum haptoglobin level in hemoglobinemia and its influence on renal excretion of hemoglobin. (13436506)
1957
36
The relationship of thermally induced hemoglobinemia to volume of skin burn. (13337619)
1956
37
Transient hemoglobinemia associated with hemoglobinuria and methemalbuminemia in the neonatal period. (13326382)
1956
38
The heat factor as a cause of hemoglobinemia in transurethral resections. (13000964)
1953
39
The significance of hemoglobinemia and associated hemosiderinuria, with particular reference to various types of hemolytic anemia. (14889070)
1951
40
Hemoglobinemia and lower nephron nephrosis following transurethral prostatic surgery. (14841851)
1951
41
Hemoglobinemia and hemoglobinuric nephrosis complicating transurethral resection of the prostate. (18139135)
1949
42
Hemoglobinemia accompanying transurethral resection of the prostate. (20259951)
1947
43
Studies of hemoglobinemia and its effect on kidney excretion. (20342795)
1947
44
Blood transfusion studies; the relationship of hemoglobinemia and of the pH of the urine to renal damage produced by injection of hemoglobin solutions into dogs. (20289794)
1947
45
Hemoglobinemia and the hemoglobinurias. (21007432)
1945
46
Hemoglobinemia and the hemoglobinurias. (21003944)
1945
47
PHYSIOLOGICAL INTRAVASCULAR HEMOLYSIS OF EXERCISE. HEMOGLOBINEMIA AND HEMOGLOBINURIA FOLLOWING CROSS-COUNTRY RUNS. (16695071)
1943
48
STUDIES OF HEMOGLOBINEMIA AND HEMOGLOBINURIA PRODUCED IN MAN BY INTRAVENOUS INJECTION OF HEMOGLOBIN SOLUTIONS. (16694823)
1941
49
THE RELATION OF THE SPLEEN TO BLOOD DESTRUCTION AND REGENERATION AND TO HEMOLYTIC JAUNDICE : II. THE RELATION OF HEMOGLOBINEMIA TO HEMOGLOBINURIA AND JAUNDICE IN NORMAL AND SPLENECTOMIZED ANIMALS. (19867581)
1912

Variations for Hemoglobinemia

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Expression for genes affiliated with Hemoglobinemia

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Expression patterns in normal tissues for genes affiliated with Hemoglobinemia

Search GEO for disease gene expression data for Hemoglobinemia.

Pathways for genes affiliated with Hemoglobinemia

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Pathways related to Hemoglobinemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.0HP, HBB

Compounds for genes affiliated with Hemoglobinemia

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Compounds related to Hemoglobinemia according to GeneCards/GeneDecks:

(show all 36)
idCompoundScoreTop Affiliating Genes
1cellulose acetate449.7HP, B2M
2vitamin b12449.7HP, B2M
3neopterin449.7HP, B2M
4rituximab44 50 1111.7B2M, HP
5uric acid44 2410.7HP, B2M
6chloroquine44 2 50 28 1113.7B2M, HP
7vitamin-e449.7HP, B2M
8urea44 24 1111.6B2M, HP
9thyroxine44 2410.6HP, B2M
10hyaluronic acid44 2410.6HP, B2M
11folate449.6B2M, HP
12sucrose44 24 1111.6B2M, HP
13porphobilinogen44 24 1111.5HBB, B2M
14vitamin a44 24 1111.5B2M, HP
1523-diphosphoglycerate449.4HP, HBB
16benzidine449.4HP, HBB
17hind iii449.4HP, HBB
18valine449.4HBB, B2M
19polysaccharide449.4B2M, HP
20glyceraldehyde 3-phosphate449.4HBB, B2M
21glucose 6-phosphate44 2410.4HP, HBB
22vitamin d449.3HP, B2M
23butyrate449.3HBB, B2M
24polyacrylamide449.2HP, HBB
25methionine449.1HP, HBB
26glutamine449.1HBB, B2M
27cyclosporin a44 28 6111.0HP, B2M
28iron44 249.9B2M, HBB, HP
29lactate448.9HP, HBB, B2M
30aspartate448.9B2M, HBB, HP
31steroid448.9B2M, HBB, HP
32alanine448.9HP, HBB, B2M
33estrogen448.9HP, HBB, B2M
34cysteine448.9B2M, HBB, HP
35serine448.8B2M, HBB, HP
36calcium44 50 24 1111.4B2M, HBB, HP

GO Terms for genes affiliated with Hemoglobinemia

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Cellular components related to Hemoglobinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1haptoglobin-hemoglobin complexGO:0318389.1HP, HBB
2endocytic vesicle lumenGO:0716829.0HP, HBB
3blood microparticleGO:0725628.9HP, HBB
4extracellular vesicular exosomeGO:0700628.5HP, HBB, B2M
5extracellular regionGO:0055768.2B2M, HBB, HP

Biological processes related to Hemoglobinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to hydrogen peroxideGO:0425429.0HP, HBB
2positive regulation of cell deathGO:0109428.7HP, HBB

Molecular functions related to Hemoglobinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hemoglobin bindingGO:0304929.0HP, HBB

Products for genes affiliated with Hemoglobinemia

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  • Antibodies
  • Proteins
  • Lysates

Sources for Hemoglobinemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet