Hemoglobinopathy malady

Wikipedia: Hemoglobinopathy is a kind of genetic defect that results in abnormal structure of one of the globin...⁴⁴ more...

MalaCards: Hemoglobinopathy, also known as hemoglobinopathies, is related to hereditary elliptocytosis and elliptocytosis. An important gene associated with Hemoglobinopathy is G6PD (glucose-6-phosphate dehydrogenase), and among its related pathways are O2/CO2 exchange in erythrocytes and African trypanosomiasis. The compounds citrate and succinylacetone have been mentioned in the context of this disorder. Related mouse phenotypes are liver/biliary system and integument.

CDC:  ²

Aliases & Descriptions:

hemoglobinopathy 6 8 hemoglobinopathies 6 32 43

Diseases related to hemoglobinopathy by text searches and GeneDecks gene sharing:

(show top 50)    (show all 262)

id	Related Disease	Score	Top Affiliating Genes
1	hereditary elliptocytosis	28.5	HP, G6PD, SLC4A1
2	elliptocytosis	28.5	HP, G6PD, SLC4A1
3	alpha thalassemia	27.7	UGT1A1, G6PD, HBA1, HBA2, HBB, HBG1
4	iron overload	27.4	UGT1A1, ALAS2, HBA2, HBB, HFE, HFE2
5	polycythemia	25.3	VWF, GP1BA, G6PD, HBA1, HBA2, HBB
6	sickle cell disease	23.2	KLF1, VWF, BTD, BCL11A, UGT1A1, GP1BA
7	thalassemia	22.7	KLF1, VWF, BLM, BCL11A, SCN2A, UGT1A1
8	malaria	19.6	VWF, BLM, SAMHD1, GP1BA, ALAS2, HSPG2
9	hemoglobin constant spring	13.8	HBA2, HBB
10	hereditary spherocytosis	13.7	G6PD, HBA2, HBB
11	neonatal anemia	13.7	HBA2, EPO
12	hemoglobinemia	13.7	HP, HBB
13	thalassemia, delta-	13.7	HBB, HBD
14	bantu siderosis	13.7	HFE, TF
15	blackwater fever	13.7	HP, G6PD
16	fetal erythroblastosis	13.7	G6PD, HBB, EPO
17	phenylketonuria	13.7	BTD, G6PD, HBB
18	heinz body anemia	13.7	HBA1, HBA2, HBB
19	congenital hemolytic anemia	13.6	HP, G6PD, TF
20	ivemark syndrome	13.6	HBA1, HBA2, HBB
21	monogenic disease	13.6	HBA1, HBA2, HBB
22	erythremia	13.6	HBA1, HBB, EPO
23	favism	13.6	HP, G6PD, HBA1
24	iron metabolism disease	13.6	HFE, TF, TFRC
25	plasmodium falciparum malaria	13.6	HP, G6PD, HBB
26	hfe-associated hereditary hemochromatosis	13.6	HFE, HFE2
27	fetal hemoglobin quantitative trait locus 1	13.6	HBG1, HBG2
28	atransferrinemia	13.6	HFE2, TF
29	hemochromatosis type 2	13.6	HFE2, HAMP
30	galactosemia	13.6	BTD, G6PD, TF
31	lymphangioma	13.6	HBA1, HBA2, PECAM1
32	hypochromic microcytic anemia	13.5	HBA2, TF
33	splenomegaly	13.5	HP, HBA2, HBB, EPO
34	congenital disorder of glycosylation type i	13.5	HP, TF
35	diamond-blackfan anemia	13.5	HBB, HBE1
36	pure red-cell aplasia	13.5	HP, TF, EPO
37	macrocytic anemia	13.5	ALAS2, TF
38	epithelioid sarcoma	13.5	HBA1, HBA2, PECAM1
39	pyruvate kinase deficiency	13.4	G6PD, HBA2, HFE, TF, EPO
40	hpfh	13.4	KLF1, HBB, HBG1, HBG2
41	nonalcoholic steatohepatitis	13.4	HBA1, HBB, HFE, TF
42	nutritional deficiency disease	13.4	HFE2, TFRC, HAMP, EPO
43	aceruloplasminemia	13.3	TF, CP
44	autonomic neuropathy	13.3	HBA1, HBA2, EPO
45	neonatal jaundice	13.3	BTD, UGT1A1, HP, G6PD
46	hypochromic anemia	13.3	ALAS2, HBA1, HBB, TF, TFRC
47	acquired immunodeficiency syndrome	13.3	HP, TF, TFRC, EPO
48	methemoglobinemia	13.3	HP, G6PD, HBA1, HBB, HBG2
49	hydrops fetalis	13.3	G6PD, HBA1, HBA2, HBB, HBE1, EPO
50	beta thalassemia	13.2	UGT1A1, G6PD, HBA2, HBB, EPO

Approved drugs:

Drug clinical trials:

MGI Mouse Phenotypes related to hemoglobinopathy:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	liver/biliary system phenotype	MP:0005370	9.0	EPO, HFE2, HBB, HSPG2, ASIP, KLF1
2	integument phenotype	MP:0010771	8.7	SLC4A1, HFE2, HBB, HBA2, ALAS2, ASIP
3	hematopoietic system phenotype	MP:0005397	8.5	KLF1, EPO, HAMP, TFRC, HFE2, ALAS2
4	renal/urinary system phenotype	MP:0005367	8.5	PECAM1, SLC4A1, THBD, HFE2, HBB, HP
5	immune system phenotype	MP:0005387	7.2	HAMP, PECAM1, SLC4A1, TFRC, HFE2, HFE
6	growth/size phenotype	MP:0005378	6.6	HDAC9, SLC12A2, SLC4A1, TFRC, THBD, HFE
7	cellular phenotype	MP:0005384	5.7	THBD, TFRC, SLC4A1, CP, PECAM1, EPO
8	cardiovascular system phenotype	MP:0005385	5.6	TFRC, SLC4A1, SLC12A2, CP, PECAM1, HDAC9
9	homeostasis/metabolism phenotype	MP:0005376	5.4	HFE, HFE2, THBD, TF, TFRC, SLC4A1
10	mortality/aging	MP:0010768	5.1	HFE, HFE2, THBD, TF, TFRC, SLC4A1

Articles related to hemoglobinopathy:

(show all 50)

id	Title	Authors	Year	Affiliating Genes
1	The effect of UGT1A1 promoter polymorphism on bilirub in response to hydroxyurea therapy in hemoglobinopathies. (20709051)	Italia K.Y.... Colah R.B.	2010	UGT1A1
2	Comprehensive and efficient HBB mutation analysis for detection of beta-hemoglobinopathies in a pan-ethnic population. (20395516)	Chan O.T.... Schrijver I.	2010	HBB
3	Hemoglobinopathies in North Africa: a review. (20113284)	Haj Khelil A.... Perrin P.	2010	HBB
4	Diagnosis of hemoglobinopathies in newborns in Venez uela hospitals. (19775947)	GimAcnez O.G.... Arends de PAcrez A.	2009	HBB
5	Newborn screening for non-sickling hemoglobinopathies . (20008178)	Hoppe C.C.	2009	HBA2
6	Nutritional deficiencies in iron overloaded patients with hemoglobinopathies. (19415722)	Claster S.... Coates T.D.	2009	CP
7	Non-cancer uses of histone deacetylase inhibitors: effects on infectious diseases and beta-hemoglobinopathies. (19355991)	Rotili D.... Mai A.	2009	HDAC9
8	BCL11A is a major HbF quantitative trait locus in three different populations with beta-hemoglobinopathies. (18691915)	Sedgewick A.E.... Chui D.H.	2008	BCL11A
9	Hematological abnormalities in patients with distal renal tubular acidosis and hemoglobinopathies. (18266205)	Khositseth S.... Yenchitsomanus P.T.	2008	SLC4A1
10	Hemoglobinopathies and glucose-6-phosphate dehydrogenase deficiency in the sub-Saharan immigrant population of the Center and South Maresme region, Catalonia, Spain. (18582416)	Heras Manso G.L.... Gil Garcia M.	2008	G6PD
11	Fetal globin stimulant therapies in the beta-hemoglobinopathies: principles and current potential. (18543545)	Perrine S.P.	2008	EPO
12	Hematological profile of twenty-nine tribal compound cases of hemoglobinopathies and G-6-PD deficiency in rural Orissa. (18923215)	Balgir R.S.	2008	G6PD
13	Pharmacogenomics and therapeutics of hemoglobinopathi es. (18275000)	Patrinos G.P.... Grosveld F.G.	2008	HBB
14	Stem cell engineering for the treatment of severe hemoglobinopathies. (18991654)	Sadelain M.... Riviere I.	2008	HBB
15	HPLC studies in hemoglobinopathies. (17699975)	Colah R.B.... Gorakshakar A.C.	2007	HBG1
16	Neonatal screening of hemoglobinopathies and G6PD deficiency in Catalonia (Spain). Molecular study of sickle cell disease associated with alpha thalassemia and G6PD deficiency (17669331)	Manu Pereira M.d.e.l. . . . . . . . . . . .M.... Vives Corrons J.L.	2007	G6PD
17	Large-scale population genetic analysis for hemoglobinopathies reveals different mutation spectra in central Greece compared to the rest of the country. (17301974)	Samara M.... Kollia P.	2007	HBB
18	Variable efficacy of recombinant human erythropoietin in anemic pregnant women with different forms of heterozygous hemoglobinopathy. (17119327)	Bencaiova G.... Breymann C.	2006	EPO
19	Evaluation of coverage by a neonatal screening program for hemoglobinopathies in the Reconcavo region of Bahia, Brazil (17096035)	Silva W.d.o.s. .S.... Grisolia C.K.	2006	HBB
20	Neonatal screening of hemoglobinopathies and glucose-6-phosphate dehydrogenase in Catalonia. Pilot study in anonymous not related population (16527153)	MaA+A_-Pereira M.d.e.l. .M.... Vives-Corrons J.L.	2006	G6PD
21	Hemoglobinopathies in newborns from Salvador, Bahia, Northeast Brazil. (15692663)	Adorno E.V.... Goncalves M.S.	2005	HBB
22	Molecular diagnosis of inherited disorders: lessons f rom hemoglobinopathies. (16138310)	Patrinos G.P.... Papadakis M.N.	2005	HBQ1
23	Iron overload in an African American woman with SS hemoglobinopathy and a promoter mutation in the X-linked erythroid-specific 5-aminolevulinate synthase (ALAS2) gene. (15885606)	Barton J.C.... Beutler E.	2005	ALAS2, HFE2, HAMP
24	Hemoglobinopathies, G6PD deficiency, and hereditary elliptocytosis in Bahrain. (15757247)	Dash S.	2004	G6PD
25	Regional experience with newborn screening for sickle cell disease, other hemoglobinopathies and G6PD deficiency. (16868367)	Nasserullah Z.... Wabel M.A.	2003	G6PD
26	Hb Siam [alpha15(A13)Gly-->Arg (alpha1) (GGT-->CGT)] is a typical alpha chain hemoglobinopathy without an alpha-thalassemic effect. (11939517)	Turbpaiboon C.... Svasti J.	2002	HBA1
27	Triple heterozygosity of a hemoglobin variant: hemoglobin Pyrgos with other hemoglobinopathies. (11843288)	Jetsrisuparb A.... Komwilaisak P.	2002	HBB
28	Development of virus vectors for gene therapy of beta chain hemoglobinopathies: flanking with a chromatin insulator reduces gamma-globin gene silencing in vivo. (12200360)	Emery D.W.... Stamatoyannopoulos G.	2002	HBG1
29	Prevention of hemoglobinopathies in non-endemic countries (11475037)	Badens C.	2001	HBB
30	Detection of ICAM-1, ICAM-2, ICAM-3, PECAM-1 and VCAM-1, evaluation of hypercoagulable state and platelet aggregation in hemoglobinopathy patients with erythroblasts. (11454542)	Garozzo G.... Bonomo P.	2001	PECAM1
31	Laboratory investigation of hemoglobinopathies and thalassemias: review and update. (10926923)	Clarke G.M.... Higgins T.N.	2000	HBB
32	An in vitro system for efficiently evaluating gene therapy approaches to hemoglobinopathies. (10694798)	Howrey R.P.... Smith C.	2000	HBB
33	Transfusion in patients with hemoglobinopathies (11204841)	de Montalembert M.	2000	HBB, HBA2
34	Distinct phenotypic expression associated with a new hyperunstable alpha globin variant (Hb heraklion, alpha1cd37(C2)Pro>0): comparison to other alpha-thalassemic hemoglobinopathies. (11042028)	Traeger-Synodinos J.... Kanavakis E.	2000	HBA2, ASIP
35	Changes of hemostatic factors in patients with hemoglobinopathies. (10770092)	Oner A.F.... Altay C.	1999	VWF, THBD
36	An alpha-thalassemic hemoglobinopathy: homozygosity for the HB Agrinio alpha 2-globin chain variant. (9629496)	Traeger-Synodinos J.... Kattamis C.	1998	HBA2
37	Resistance to recombinant erythropoietin in a hemodialysis patient with heterozygous hemoglobinopathy J-Meinung. (9159314)	Tarng D.C.... Huang T.P.	1997	EPO, HP
38	Beta-globin haplotypes from blood spots for follow-up of newborn hemoglobinopathy screening. (8980265)	Hiti A.L.... Powars D.R.	1997	HBB
39	Hb Sun Prairie: diagnostic pitfalls in thalassemic hemoglobinopathies. (8811313)	Ho P.J.... Thein S.L.	1996	HBB, HBA2
40	Neonatal screening of hemoglobinopathies in a population residing in Portugal (9005686)	Peres M.J.... Martins M.C.	1996	HBA2
41	Advances in the prenatal and molecular diagnosis of the hemoglobinopathies and thalassemias. (8537229)	Embury S.H.	1995	HBB
42	Potential alternatives to erythrocyte transfusion in hemoglobinopathies: hydroxyurea (HU), erythropoietin (EPO), butyrate derivatives, blood substitutes (8186851)	Bachir D.... Galacteros F.	1994	EPO
43	Prevalences of thalassemia/hemoglobinopathies and G-6-PD deficiency in malaria patients. (7964225)	Insiripong S.... Amatachaya C.	1993	G6PD
44	Hemoglobinopathies and glucose-6-phosphate dehydrogenase deficiency in hospital births in Bahrain. (17587043)	Mohammed A.M.... Bapat J.P.	1992	G6PD
45	Hemoglobin Cagliari (beta 60 [E4] Val----Glu): a nove l unstable thalassemic hemoglobinopathy. (1985702)	Podda A.... Cao A.	1991	HBB, HBA2
46	Prenatal diagnosis of thalassemia and hemoglobinopathies in Switzerland. (2009949)	Beris P.... Miescher P.	1991	HBB
47	The recombinant human parvoviruses for gene therapy of hemoglobinopathies. (1366418)	Dixit M.... Ohi S.	1990	HBB
48	Hemoglobinopathies in Japan. (7275668)	Shibata S.	1981	HBA1
49	Polycythemia associated with a hemoglobinopathy. (5913291)	Charache S.... Clegg J.B.	1966	HBA1
50	Hemoglobin 'pylos': study of a hemoglobinopathy resembling thalassemia in the heterozygous, homozygous and double heterozygous state. (13892631)	Fessas P.... Karaklis A.	1962	HBD

Genes related to hemoglobinopathy according to GeneCards:

(show all 37)

id	Symbol	Description	Score	GeneCards Section Context
1	G6PD	glucose-6-phosphate dehydrogenase	11.0	Publications
2	HBA2	hemoglobin, alpha 2	11.0	Publications
3	HBG1	hemoglobin, gamma A	11.0	Publications
4	HBB	hemoglobin, beta	11.0	Publications
5	KLF1	Kruppel-like factor 1 (erythroid)	11.0
6	PECAM1	platelet/endothelial cell adhesion molecule 1	11.0	Publications
7	BTD	biotinidase	11.0
8	HP	haptoglobin	11.0	Publications
9	TFRC	transferrin receptor (p90, CD71)	11.0
10	HFE	hemochromatosis	11.0
11	EPO	erythropoietin	11.0	Publications
12	TF	transferrin	11.0
13	HBQ1	hemoglobin, theta 1	11.0	Publications
14	HBM	hemoglobin, mu	11.0
15	HFE2	hemochromatosis type 2 (juvenile)	11.0	Publications
16	ASIP	agouti signaling protein	11.0	Publications
17	HBD	hemoglobin, delta	11.0	Publications
18	HBA1	hemoglobin, alpha 1	11.0	Publications
19	HBE1	hemoglobin, epsilon 1	11.0
20	ALAS2	aminolevulinate, delta-, synthase 2	11.0	Publications
21	HAMP	hepcidin antimicrobial peptide	11.0	Publications
22	SAMHD1	SAM domain and HD domain 1	11.0
23	BCL11A	B-cell CLL/lymphoma 11A (zinc finger protein)	11.0	Publications
24	CFB	complement factor B	11.0
25	SLC4A1	solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)	11.0	Publications
26	GP1BA	glycoprotein Ib (platelet), alpha polypeptide	11.0
27	UGT1A1	UDP glucuronosyltransferase 1 family, polypeptide A1	11.0	Publications
28	SLC12A2	solute carrier family 12 (sodium/potassium/chloride transporters), member 2	11.0
29	SCN2A	sodium channel, voltage-gated, type II, alpha subunit	11.0
30	HBS1L	HBS1-like (S. cerevisiae)	11.0
31	HBG2	hemoglobin, gamma G	11.0
32	THBD	thrombomodulin	11.0	Publications
33	CP	ceruloplasmin (ferroxidase)	11.0	Publications
34	BLM	Bloom syndrome, RecQ helicase-like	11.0
35	VWF	von Willebrand factor	11.0	Publications
36	HSPG2	heparan sulfate proteoglycan 2	11.0
37	HDAC9	histone deacetylase 9	11.0	Publications

Pathways related to hemoglobinopathy according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	O2/CO2 exchange in erythrocytes38	9.9	HBA1, HBA2, HBB, SLC4A1
2	African trypanosomiasis20	9.9	HBD, HBB, HBA2, HBA1
3	Malaria20	9.8	PECAM1, HBD, HBB, HBA2, HBA1
4	Porphyrin and chlorophyll metabolism20	9.5	UGT1A1, ALAS2, CP
5	Factors involved in megakaryocyte development and platelet production38	9.5	HBD, HBE1, HBG1, HBG2
6	Blood Coagulation Signaling Pathways37	8.9	THBD, GP1BA, VWF

Compounds related to hemoglobinopathy according to GeneDecks:

(show top 50)    (show all 140)

id	Compound	Score	Top Affiliating Genes
1	citrate32	10.4	HP, TFRC, SLC4A1
2	succinylacetone32	10.3	TF, EPO, TFRC, HBB
3	deferiprone32	10.3	TFRC, EPO, TF
4	zinc protoporphyrin32	10.2	EPO, TFRC, TF, G6PD, HP
5	sialic acid32	10.2	TFRC, PECAM1, EPO, HP
6	iron dextran32 9 9	12.2	TFRC, EPO, TF, HBB, HBA1
7	5-aminolevulinic acid32 18	11.2	ALAS2, HBB, HBG1, HFE, TFRC
8	protoporphyrin ix32 9 18 9	13.1	EPO, TFRC, HP, ALAS2, TF
9	benzidine32	10.0	UGT1A1, HBB, HBG1, TFRC, EPO, HP
10	23-diphosphoglycerate32	9.9	G6PD, HBA2, HP, HBB, HBG2, EPO
11	aspartate32	9.9	HP, HBB, THBD, ALAS2, HFE
12	tocopherol32	9.7	HP, G6PD, TF, CP, HBG2
13	fenton32	9.6	TF, EPO, CP, HBG2
14	fe2+32	9.6	CP, TFRC, TF, HFE, HBG2
15	polyethylene glycol32	9.5	TF, THBD, HBG2, G6PD, TFRC, HP
16	deferoxamine32 9 9	11.5	CP, HP, HBG2, TF, TFRC, EPO
17	carbohydrates32	9.5	CP, TFRC, TF, THBD
18	fe3+32	9.5	TFRC, CP, TF, HBG2
19	malondialdehyde32	9.4	EPO, CP, HBG2, HP, G6PD
20	chloroquine32 34 9 9	12.4	HP, G6PD, TF, TFRC, HDAC9
21	azathioprine32 34 9 9	12.4	EPO, G6PD, HBB, HBG1, THBD, HDAC9
22	ascorbic acid32 18	10.4	G6PD, TF, TFRC, HSPG2, HFE, EPO
23	vitamin b1232	9.2	EPO, CP, TFRC, TF, G6PD, VWF
24	butyrate32	9.1	ALAS2, HBA2, HBB, HBG1, HDAC9, EPO
25	glutamate32	9.1	HBB, SLC4A1, SLC12A2, CP, HDAC9
26	Heme9 18 9	10.9	HFE, HBQ1, HBM, HBG2, HBG1, HBE1
27	sodium nitroprusside32	8.9	TF, TFRC, CP, G6PD, VWF, HBG2
28	betacarotene32	8.9	VWF, TF, CP, THBD, TFRC
29	thyroxine32 18	9.7	VWF, UGT1A1, TF, THBD, HP, G6PD
30	epinephrine32 9 18 9	11.6	CP, TF, HBG2, G6PD, HP, GP1BA
31	hydroxyurea32 9 9	10.6	HBA2, HDAC9, EPO, HBG2, HBG1, TFRC
32	nitric oxide32 9 18 9	11.6	HBG1, HP, PECAM1, HBB, SLC4A1, THBD
33	n-ethylmaleimide32 9 9	10.5	G6PD, TFRC, HBG2, HSPG2, VWF, GP1BA
34	folate32	8.5	CP, THBD, G6PD, HP, EPO, SLC4A1
35	cysteine32	8.4	HBB, HBG2, TFRC, SLC4A1, HDAC9, BTD
36	aspirin32 34 18	10.3	HP, G6PD, VWF, GP1BA, HSPG2, THBD
37	iron32 18	9.3	HFE, HBG1, HBB, HBA2, HBA1, HP
38	creatinine32	8.1	G6PD, TF, HBG2, EPO, HAMP, CP
39	prostacyclin32	8.1	PECAM1, TF, THBD, HBG2, HSPG2, GP1BA
40	pge132	8.0	VWF, HSPG2, THBD, TF, TFRC
41	oxygen32 18	8.9	HAMP, HBB, HBA2, HBA1, HBG2, SLC12A2
42	glutamine32	7.7	HDAC9, TFRC, TF, HBB, G6PD, HSPG2
43	estrogen32	7.6	TF, HBB, HFE, THBD, HDAC9, PECAM1
44	atp32	7.2	HBA2, HBB, THBD, SLC4A1, SLC12A2, PECAM1
45	lactate32	7.1	THBD, HBG2, HBB, G6PD, HP, BTD
46	h2o232	7.1	TFRC, VWF, HP, G6PD, HBB, HSPG2
47	vegf32	7.0	VWF, HSPG2, HP, THBD, TFRC, TF
48	tyrosine32	6.6	TFRC, HBB, HDAC9, BTD, EPO, HSPG2
49	serine32	6.5	HP, HDAC9, PECAM1, CP, TFRC, THBD
50	alanine32	5.8	THBD, VWF, UGT1A1, HBA2, GP1BA, ALAS2

Cellular components related to hemoglobinopathy according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	haptoglobin-hemoglobin complex	GO:031838	9.8	HBB, HBA2, HP
2	hemoglobin complex	GO:005833	9.0	HBA2, HBB, HBD, HBE1, HBG1, HBG2
3	extracellular space	GO:005615	7.9	PECAM1, CP, THBD, HFE2, HP, HSPG2

Biological processes related to hemoglobinopathy according to GeneDecks:

(show all 8)

id	Name	GO ID	Score	Top Affiliating Genes
1	oxygen transport	GO:015671	10.2	HBQ1, HBB, HBA2
2	erythrocyte maturation	GO:043249	10.2	KLF1, G6PD, EPO
3	hemoglobin biosynthetic process	GO:042541	10.1	ALAS2, EPO
4	positive regulation of cell death	GO:010942	10.1	HP, HBA2, HBB
5	bicarbonate transport	GO:015701	9.9	SLC4A1, HBB, HBA2
6	response to hydrogen peroxide	GO:042542	9.8	HP, HBA2, HBB
7	cellular iron ion homeostasis	GO:006879	9.2	ALAS2, HAMP, CP, TFRC, TF, HFE
8	blood coagulation	GO:007596	8.1	PECAM1, TF, THBD, HBG2, HBG1, HBE1

Molecular functions related to hemoglobinopathy according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	haptoglobin binding	GO:031720	10.3	HBA2, HBB
2	oxygen transporter activity	GO:005344	9.1	HBA2, HBQ1, HBM, HBG2, HBG1, HBE1
3	oxygen binding	GO:019825	9.1	HBQ1, HBM, HBG2, HBG1, HBE1, HBD
4	heme binding	GO:020037	9.0	HBQ1, HBM, HBG2, HBG1, HBE1, HBD
5	iron ion binding	GO:005506	8.8	HBQ1, HBM, HBG2, HBG1, HBE1, HBD