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Hemoglobinuria malady
58 genes, 8 tissues, 487 related diseases, 15 phenotypes, 196 articles, clinical trials.

Summaries for Hemoglobinuria

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44Wikipedia, 22MalaCards
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Wikipedia: In medicine, hemoglobinuria or haemoglobinuria is a condition in which the oxygen transport protein...44 more...

MalaCards: Hemoglobinuria, also known as hemoglobinuria (context-dependent category), is related to paroxysmal nocturnal hemoglobinuria and aplastic anemia. An important gene associated with Hemoglobinuria is PIGA (phosphatidylinositol glycan anchor biosynthesis, class A), and among its related pathways are Glycosylphosphatidylinositol(GPI)-anchor biosynthesis and Cell adhesion molecules (CAMs). The compounds hirudin and dmso have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, kidney and liver, and related mouse phenotypes are liver/biliary system and renal/urinary system.

Aliases & Descriptions for Hemoglobinuria

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6Disease Ontology, 8DISEASES, 32Novoseek , 43UMLS, 27NCIt, 40SNOMED-CT, 24MeSH, 19ICD9CM
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Aliases & Descriptions:

hemoglobinuria 6 8 32 43
hemoglobinuria (context-dependent category) 6
hemoglobinuria (finding) 6
haemoglobinuria 6

External Ids:

ICD9CM19 791.2

Related Diseases for Hemoglobinuria

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13GeneCards, 14GeneDecks
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Diseases related to hemoglobinuria by text searches and GeneDecks gene sharing:

(show top 50)    (show all 484)
idRelated DiseaseScoreTop Affiliating Genes
1paroxysmal nocturnal hemoglobinuria37.3PIGA, RECK, SELL, BST1, CD58, CD14
2aplastic anemia32.3PIGA, CD58, CD59, CD55, HPRT1, TFRC
3hematopoiesis29.6PIGA, CD14, HPRT1, HMGA2, WT1, G6PD
4pancytopenia29.0PIGA, CD59, CD55, HP, WT1, TCN2
5myelodysplastic syndrome28.7PIGA, SELL, CD59, CD55, ANXA5, HPRT1
6retinal vascular occlusion27.8PIGA, SELP, MTHFR
7myelofibrosis27.6CEACAM8, HMGA2, PLAUR, WT1, CSF3, EPO
8was-related disorders26.7PIGA, HLA-B, PLAT, WT1, ACHE, PRNP
9protein s deficiency26.5PIGA, PIK3C2A, RECK, MTHFR, CD58, FCGR3B
10sepsis26.1RECK, SELL, SELP, CD14, CD55, FCGR3A
11duodenitis25.9CD14, CD59, CD55, HLA-A, HLA-B, HLA-DQA1
12anemia25.3PIGA, VWF, SELL, SELP, MTHFR, CD58
13venous thrombosis25.1VWF, SELP, MTHFR, MB, F10, HLA-B
14pulmonary hypertension24.5PIK3C2A, VWF, SELP, ANXA5, ALDH7A1, HP
15thrombosis23.0PIGA, PIK3C2A, RECK, VWF, SELL, SELP
16acute leukemia22.6VWF, SELL, SELP, MTHFR, CD58, CD14
17acute myocardial infarction22.2PIK3C2A, VWF, SELL, SELP, MTHFR, CD14
18myocardial infarction21.7PIK3C2A, RECK, VWF, SELL, SELP, MTHFR
19cholesterol21.7PIK3C2A, RECK, VWF, SELL, SELP, LBR
20retinitis21.5PIGA, PIGF, PIK3C2A, VWF, SELP, MTHFR
21hypertension21.3PIK3C2A, VWF, SELL, SELP, MTHFR, CD59
22leukemia16.7PIGA, PIK3C2A, RECK, KIR2DS4, VWF, SELL
23x-linked sideroblastic anemia13.8PIGA, CD59, CD55
24fetal erythroblastosis13.7CD55, G6PD, EPO
25dyserythropoietic anemia with thrombocytopenia13.6PIGA, CD59, CD55, CSF3, EPO
26congenital hypothyroidism13.6KIR2DS4, HP, ACHE, G6PD
27t-lymphocytopenia13.6LBR, CD59, ANXA5
28birdshot chorioretinopathy13.5KIR2DS4, HLA-A, HLA-C
29autoimmune thyroiditis13.5CD58, CD59, CD55, HLA-B
30hereditary spherocytosis13.5HP, G6PD, TFRC, EPO
31spherocytosis13.4HP, G6PD, TFRC, EPO
32cerebral malaria13.4SELP, HP, G6PD, TCN2
33chronic granulomatous disease13.4CD14, G6PD, CSF3, EPO
34hairy cell leukemia13.4RECK, CD52, ANXA5, CSF3, EPO
35celiac disease13.4HLA-DQA1, HLA-DQB1
36alpha thalassemia13.4HP, WT1, G6PD, EPO
37quebec platelet disorder13.4SELP, F10, PLAU
38t cell deficiency13.4PIGA, ANXA5, HPRT1, PLCG1, PLAUR
39extrinsic allergic alveolitis13.4CD14, HP, HLA-DRB1
40microcytic anemia13.4G6PD, TFRC, EPO
41autoimmune hemolytic anemia13.4PIGA, VWF, CD59, CD52, CD55, HP
42protein c deficiency13.4MTHFR, PLAU, PLG, CSF3
43al amyloidosis13.4VWF, CD14, F10, CSF3
44sympathetic ophthalmia13.3HLA-C, HLA-DQA1, HLA-DRB1
45lymphoproliferative syndrome13.3LBR, CD59, CD52, CD55, HPRT1, HLA-A
46oral lichen planus13.3CD58, CD14, FCGR3B, HLA-A, HLA-C
47tubulointerstitial nephritis and uveitis13.3HLA-DQA1, HLA-DQB1, HLA-DRB1
48antithrombin iii deficiency13.3MTHFR, F10, PLG
49blood platelet disease13.3RECK, VWF, F10
50pyruvate kinase deficiency13.3MTHFR, ANXA5, G6PD, EPO

Graphical network of the top 20 diseases related to hemoglobinuria:



Graphical network of diseases related to hemoglobinuria

Clinical Features for Hemoglobinuria

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Drugs & Therapeutics for Hemoglobinuria

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4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Hemoglobinuria

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Anatomical Context for Hemoglobinuria

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22MalaCards
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MalaCards organs/tissues related to hemoglobinuria:

22
Bone marrow, Kidney, Liver, Monocytes, Nk cells, T cells, B cells, Endothelial

Phenotypes for genes affiliated with Hemoglobinuria

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25MGI
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MGI Mouse Phenotypes related to hemoglobinuria:

25 (show all 15)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1liver/biliary system phenotypeMP:00053709.9EPO, C3, PLG, HPRT1, RECK
2renal/urinary system phenotypeMP:00053679.5C3, GFRA1, WT1, PLG, HPRT1, CD55
3respiratory system phenotypeMP:00053889.1ACHE, HPRT1, MB, CD14, SELP, SELL
4integument phenotypeMP:00107719.0CSF3, GFRA1, PLCG1, NRAS, HMGA2, HPRT1
5reproductive system phenotypeMP:00053898.8WT1, ACHE, PRNP, C3, PLG, HMGA2
6digestive/alimentary phenotypeMP:00053818.4C3, TFRC, GFRA1, PLG, PLAU, PLAT
7muscle phenotypeMP:00053698.1WT1, ACHE, GFRA1, PRNP, PLAUR, PLAU
8nervous system phenotypeMP:00036318.0HLA-DQB1, PLAU, PLAUR, PLG, ACHE, G6PD
9hematopoietic system phenotypeMP:00053978.0PIGA, EPO, C8B, CSF3, TFRC, KLRK1
10immune system phenotypeMP:00053877.4PLAT, PLCG1, PLAUR, PLG, WT1, GFRA1
11cardiovascular system phenotypeMP:00053856.7PLCG1, PLAU, PLAUR, PLG, WT1, G6PD
12growth/size phenotypeMP:00053786.4PLAT, PLCG1, PLAU, PLAUR, PLG, WT1
13cellular phenotypeMP:00053846.0WT1, PLG, PLAUR, PLAU, PLCG1, KLRK1
14mortality/agingMP:00107684.9WT1, PLG, PLAU, PLCG1, PLAT, NRAS
15homeostasis/metabolism phenotypeMP:00053764.5PLAUR, PLAU, PLAT, NRAS, HLA-DQB1, PLG

Publications for genes affiliated with Hemoglobinuria

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35PubMed
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Articles related to hemoglobinuria:

(show top 50)    (show all 196)
idTitleAuthorsYearAffiliating Genes
1Guidelines for the diagnosis and monitoring of paroxy smal nocturnal hemoglobinuria and related disorders by flow cytometry. (20533382)Borowitz M.J.... Richards S.J.2010PIGA
2Paroxysmal nocturnal hemoglobinuria (19303177)Peffault de Latour R.... SociAc G.2010CD59, PIGA
3Eculizumab in paroxysmal nocturnal hemoglobinuria (20035691)SociAc G.... Peffault de Latour R.2009PIGA
4Detection of paroxysmal nocturnal hemoglobinuria clones in patients with myelodysplastic syndromes and related bone marrow diseases, with emphasis on diagnostic pitfalls and caveats. (19001281)Wang S.A.... Woda B.A.2009CD55, CD59
5Advances in the diagnosis and therapy of paroxysmal n octurnal hemoglobinuria. (18063459)Brodsky R.A.2008PIGA
6Haptoglobin therapy during pregnancy for paroxysmal nocturnal hemoglobinuria with renal failure. (17459392)Shibasaki T.... Furuya K.2007HP
7Erythopoietin treatment during complement inhibition with eculizumab in a patient with paroxysmal nocturnal hemoglobinuria. (17405753)Hill A.... Hillmen P.2007EPO
8Molecular basis of clonal expansion of hematopoiesis in 2 patients with paroxysmal nocturnal hemoglobinuria (PNH). (16940417)Inoue N.... Kinoshita T.2006PIGA, HMGA2
9Ultrastructural study of platelets patients with paroxysmal nocturnal hemoglobinuria (17408109)Vega S.... Cerecedo-Mercado D.A.2006SELP
10Mean fluorescence intensity rate is a useful marker in the detection of paroxysmal nocturnal hemoglobinuria clones. (16176170)Hevessy Z.... Kappelmayer J.2005PIGA
11Budd-Chiari syndrome in a paroxysmal nocturnal hemoglobinuria patient with coexistence of factor II and MTHFR mutations. (15869626)Shamseddine A.I.... Taher A.T.2005MTHFR
12Expression of CD59 on lymphocyte and the subsets and its potential clinical application for paroxysmal nocturnal hemoglobinuria diagnosis. (15053802)Cui W.... Zhang Z.2004CD59
13Effect of eculizumab on hemolysis and transfusion requirements in patients with paroxysmal nocturnal hemoglobinuria. (14762182)Hillmen P.... Rother R.P.2004PIGA
14Recent insights into the pathophysiology of paroxysmal nocturnal hemoglobinuria. (12883466)Meletis J.... Terpos E.2003PIGA
15A SIN lentiviral vector containing PIGA cDNA allows long-term phenotypic correction of CD34+-derived cells from patients with paroxysmal nocturnal hemoglobinuria. (12668126)Robert D.... Moreau-Gaudry F.2003PIGA
16CD34+ cells from paroxysmal nocturnal hemoglobinuria (PNH) patients are deficient in surface expression of cellular prion protein (PrPc). (12543108)Risitano A.M.... Maciejewski J.P.2003PRNP, PIGA
17History of paroxysmal nocturnal hemoglobinuria (19569576)ChrobA!k L.2002PIGA
18HLA class II haplotype and quantitation of WT1 RNA in Japanese patients with paroxysmal nocturnal hemoglobinuria. (12070003)Shichishima T.... Maruyama Y.2002WT1, HLA-DQA1, HLA-DQB1
19Diagnostic significance of measurement of the receptor for urokinase-type plasminogen activator on granulocytes and in plasma from patients with paroxysmal nocturnal hemoglobinuria. (12041678)Gao W.... Ruan C.2002PLAU
20Paroxysmal nocturnal hemoglobinuria: insights from recent advances in molecular biology. (11668433)Bessler M.... Keller P.2001PIGA
21Successful unrelated donor bone marrow transplantatio n for paroxysmal nocturnal hemoglobinuria. (11319587)Woodard P.... Bowman L.2001PIGA
22Detection of somatic mutations of the PIG-A gene in Brazilian patients with paroxysmal nocturnal hemoglobinuria. (11378665)Franco De Carvalho R.... Costa F.F.2001PIGA
23The molecular basis of paroxysmal nocturnal hemoglobinuria. (10629597)Rosti V.2000PIGA
24Leukemia arising out of paroxysmal nocturnal hemoglobinuria. (10048414)Harris J.W.... Medof M.E.1999PIGA
25Paroxysmal nocturnal hemoglobinuria: analysis of the effects of mutant PIG-A on gene expression. (10440907)Kanai N.... Parker C.J.1999ALDH7A1, PIGA
26Paroxysmal nocturnal hemoglobinuria: An acquired genetic disease. (10539884)Nishimura J.... Kinoshita T.1999CD55, CD59
27Resistance of paroxysmal nocturnal hemoglobinuria cells to the glycosylphosphatidylinositol-binding toxin aerolysin. (10029605)Brodsky R.A.... Buckley J.T.1999PIGA
28Different roles of glycosylphosphatidylinositol in various hematopoietic cells as revealed by a mouse model of paroxysmal nocturnal hemoglobinuria. (10556178)Murakami Y.... Takeda J.1999PIGA
29Paroxysmal nocturnal hemoglobinuria and its association with aplastic anemia (9748736)Pavlu J.... Necas E.1998PIGA
30Genotypic and phenotypic implications in paroxysmal nocturnal hemoglobinuria (PNH): a preliminary investigation. (9640601)Pakdeesuwan K.... Wanachiwanawin W.1997PIGA
31Markedly high plasma erythropoietin and granulocyte-colony stimulating factor levels in patients with paroxysmal nocturnal hemoglobinuria. (9479872)Nakakuma H.... Takatsuki K.1997CSF3
32Analysis of PIG-A gene in a patient who developed reciprocal translocation of chromosome 12 and paroxysmal nocturnal hemoglobinuria during follow-up of aplastic anemia. (8619404)Nishimura J.I.... Takeda J.1996PIGA
33Role of phosphatidylinositol-linked proteins in paroxysmal nocturnal hemoglobinuria pathogenesis. (8712763)Kinoshita T.... Takeda J.1996PIGA
34Paroxysmal nocturnal hemoglobinuria: the price for a chance. (8946596)Bessler M.1996PIGA
35Molecular basis of the heterogeneity of expression of glycosyl phosphatidylinositol anchored proteins in paroxysmal nocturnal hemoglobinuria. (8630422)Endo M.... Parker C.J.1996PIGA
36Glycosyl phosphatidylinositol-linked blood group antigens and paroxysmal nocturnal hemoglobinuria. (8542026)Telen M.J.1995PIGA, SEMA7A
37Paroxysmal nocturnal hemoglobinuria clone in bone marrow of patients with pancytopenia. (7532041)Nakakuma H.... Takatsuki K.1995CD55, CD59
38The PIG-A gene somatic mutation responsible for paroxysmal nocturnal hemoglobinuria. (8647522)Rotoli B.... Boccuni P.1995PIGA
39Negative Ham's test and sugar water test on admissio n in paroxysmal nocturnal hemoglobinuria (7967061)Noji H.... Maruyama Y.1994HP
40Chromosomal assignment of genes involved in glycosylphosphatidylinositol anchor biosynthesis: implications for the pathogenesis of paroxysmal nocturnal hemoglobinuria. (8204896)Ware R.E.... Seldin M.F.1994PIGF, PIGH
41Characterization of alternatively spliced PIG-A transcripts in normal and paroxysmal nocturnal hemoglobinuria cells. (8081230)Yu J.... Medof M.E.1994PIGA
42Expression of recombinant transmembrane CD59 in paroxysmal nocturnal hemoglobinuria B cells confers resistance to human complement. (7522635)Rother R.P.... Squinto S.P.1994CD55, CD59
43A deficiency in CDw52 (CAMPATH-1 antigen) of paroxysmal nocturnal hemoglobinuria lymphocytes. (8260716)Nagakura S.... Kagimoto T.1993CD52
44Expression of decay-accelerating factor and CD59 in lymphocyte subsets of healthy individuals and paroxysmal nocturnal hemoglobinuria patients. (7686331)Nagakura S.... Takatsuki K.1993CD55, CD59
45Complement-induced vesiculation and exposure of membrane prothrombinase sites in platelets of paroxysmal nocturnal hemoglobinuria. (7688991)Wiedmer T.... Sims P.J.1993F10
46Assembly and deacetylation of N-acetylglucosaminyl-plasmanylinositol in normal and affected paroxysmal nocturnal hemoglobinuria cells. (1708886)Hirose S.... Medof M.E.1991PLCG1, GPLD1
47Acetylcholinesterase and lymphocyte function-associated antigen 3 found on decay-accelerating factor-negative erythrocytes from some patients with paroxysmal nocturnal hemoglobinuria are lost during erythrocyte aging. (1688724)Ueda E.... Kitani T.1990ACHE, CD55, CD58
48High-dose recombinant human erythropoietin for treatment of anemia in myelodysplastic syndromes and paroxysmal nocturnal hemoglobinuria: a pilot study. (2226680)Stebler C.... Speck B.1990EPO
49Paroxysmal nocturnal hemoglobinuria (2182938)Blaas P.... Peter H.H.1990CD55
50Analysis of PI (phosphatidylinositol)-anchoring antigens in a patient of paroxysmal nocturnal hemoglobinuria (PNH) reveals deficiency of 1F5 antigen (CD59), a new complement-regulatory factor. (1689670)Taguchi R.... Nakashima I.1990CD59

Expression for genes affiliated with Hemoglobinuria

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Hemoglobinuria

Pathways for genes affiliated with Hemoglobinuria

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20KEGG, 38Reactome, 41Thomson Reuters, 36QIAGEN, 10EMD Millipore, 37R&D Systems, 34PharmGKB
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Pathways related to hemoglobinuria according to GeneDecks:

(show all 49)
idPathwayScoreTop Affiliating Genes
1Glycosylphosphatidylinositol(GPI)-anchor biosynthesis2010.5PIGA, PIGF, PIGH, GPLD1
2Cell adhesion molecules (CAMs)2010.4SELL, SELP, CD58
3Dissolution of Fibrin Clot3810.2PLAUR, PLAU, PLAT
4Immune response_Lectin induced complement pathway4110.2C8B, C9, CD55, CD59
5Alternative Complement Pathway3610.1C8B, C3, C9
6Cell surface interactions at the vascular wall3810.1PLCG1, NRAS, CD58, SELP, SELL
7Lectin Induced Complement Pathway3610.1C8B, C3, C9
8Immune response_Alternative complement pathway4110.0C8B, C3, C9, CD55, CD59
9Immune response Alternative complement pathway1010.0C8B, C3, C9, CD55, CD59
10Immune response Lectin Induced complement pathway1010.0C8B, C3, C9, CD55, CD59
11Classical Complement Pathway3610.0C8B, C3, C9
12Immune response Classic complement pathway1010.0C8B, C3, C9, CD55, CD59
13Immune response_Classical complement pathway4110.0CD59, CD55, C9, C3, C8B
14Immune response_Role of DAP12 receptors in NK cells4110.0KLRC2, HLA-C, HLA-B
15Graft-versus-host disease2010.0HLA-DQA1, HLA-C, HLA-B, HLA-A
16Complement Pathway3610.0C9, C3, C8B
17Cell adhesion_PLAU signaling4110.0PLG, PLAUR, PLAU, PLAT
18Cell adhesion PLAU signaling109.9PLG, PLAUR, PLAU, PLAT
19Calcium Mediated T-Cell Apoptosis369.9HLA-DQA1, HLA-DQB1, HLA-DRB1, PLCG1
20G-protein signaling N-RAS regulation pathway109.9HLA-DQA1, HLA-DQB1, HLA-DRB1, NRAS, PLCG1
21Immune response Role of DAP12 receptors in NK cells109.9KLRC2, PLCG1, HLA-C, HLA-B
22Hematopoietic cell lineage209.9EPO, CSF3, TFRC, HLA-DRB1, CD55, CD59
23G-protein signaling_N-RAS regulation pathway419.9PLCG1, NRAS, HLA-DRB1, HLA-DQB1, HLA-DQA1
24Cell adhesion_ECM remodeling419.8PLG, PLAUR, PLAU, PLAT
25Cell adhesion ECM remodeling109.8PLG, PLAUR, PLAU, PLAT
26Antigen processing and presentation209.8KLRC2, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-C, KIR2DS4
27IL-4 Pathway369.8NRAS, HLA-DRB1, HLA-DQB1, HLA-DQA1
28PKC-Theta Pathway369.7HLA-DQA1, HLA-DQB1, HLA-DRB1, NRAS, PLCG1
29MHC class II antigen presentation389.7HLA-DQA1, HLA-DQB1, HLA-DRB1
30Immune System389.6KIR2DS4, FCGR3A, KLRC2, KLRK1
31Blood Coagulation Signaling Pathways379.6PLG, PLAU, PLAT, F10, VWF
32VEGF Signaling Pathway349.6PLCG1, NRAS, PIK3C2A, PIGF
33CTL Mediated Apoptosis369.4HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-C, HLA-B, HLA-A
34Allograft rejection209.4HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-C, HLA-B, HLA-A
35Type I diabetes mellitus209.4HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-C, HLA-B, HLA-A
36Autoimmune thyroid disease209.4HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-C, HLA-B, HLA-A
37TCR Signaling369.4PLCG1, NRAS, HLA-DRB1, HLA-DQB1, HLA-DQA1
38Viral myocarditis209.4HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-C, HLA-B, HLA-A
39Leishmaniasis209.4C3, HLA-DRB1, HLA-DQB1, HLA-DQA1, FCGR3B, FCGR3A
40CTLA4 Signaling369.3HLA-DQA1, HLA-DQB1, HLA-DRB1, PLCG1
41CDC42 Pathway369.3HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-C, HLA-B, HLA-A
42Tuberculosis209.3C3, HLA-DRB1, HLA-DQB1, HLA-DQA1, FCGR3B, FCGR3A
43ICos-ICosL Pathway in T-Helper Cell369.1PLCG1, HLA-DRB1, HLA-DQB1, HLA-DQA1, PIK3C2A
44CD28 Signaling in T-Helper Cell369.1PIK3C2A, HLA-DQA1, HLA-DQB1, HLA-DRB1, PLCG1
45Natural killer cell mediated cytotoxicity209.1KLRK1, KLRC2, PLCG1, NRAS, HLA-C, HLA-B
46Staphylococcus aureus infection209.0C3, PLG, HLA-DRB1, HLA-DQB1, HLA-DQA1, FCGR3B
47Systemic lupus erythematosus208.8C8B, C3, C9, HLA-DRB1, HLA-DQB1, HLA-DQA1
48Complement and coagulation cascades208.8VWF, C8B, C3, C9, PLG, PLAUR
49Phagosome208.4HLA-DQB1, HLA-DRB1, TFRC, C3, HLA-DQA1, HLA-C

Compounds for genes affiliated with Hemoglobinuria

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32Novoseek , 9DrugBank, 34PharmGKB, 18HMDB, 42Tocris Bioscience
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Compounds related to hemoglobinuria according to GeneDecks:

(show top 50)    (show all 194)
idCompoundScoreTop Affiliating Genes
1hirudin32 10.3F10, PLAU, SELL, PLAUR
2dmso32 10.2SELP, PRNP, G6PD, HPRT1
3phosphatidylserine32 9 9 12.1CD14, VWF, FCGR3B, RECK, F10
4rituximab32 34 9 9 13.0FCGR3B, CD59, CD52, CD55, FCGR3A
5glycolipid32 10.0PRNP, PLAU, PLCG1, CD55, HLA-B, CD59
6sialic acid32 9.9SELL, CD59, CD55, GPLD1, RECK, HP
7methylcellulose32 9.8EPO, CSF3, TFRC, PIGA, CD14, CD59
8ascorbic acid32 18 10.7EPO, TFRC, G6PD, HPRT1, F10, ANXA5
9abciximab32 9 9 11.5FCGR3A, F10, ANXA5, VWF, FCGR3B
10tranexamic acid32 9 9 11.5PLAU, PLAUR, PLG, EPO, PLAT, VWF
11pge232 9.4CD14, HP, PLCG1, PRNP, PLAU, PLAUR
12fitc32 9.4CD59, TFRC, HLA-B, ANXA5, CD55, SELL
13fmlp32 9.3SELP, CEACAM8, CD14, CD59, CSF3, FCGR3B
14folate32 9.2TFRC, G6PD, PLCG1, EPO, HPRT1, MTHFR
15carbohydrates32 9.2PLAUR, TFRC, ANXA5, SELP, CD58, CD14
16glutamate32 9.1PLAU, PLCG1, HPRT1, F10, ANXA5, MTHFR
17kininogen32 9.0VWF, PLG, PLAUR, PLAU, PLAT, HP
18vitamin b1232 8.9VWF, TFRC, HP, MB, TCN2, EPO
19aspirin32 34 18 10.7PLAU, PLAUR, G6PD, CD59, HP, PLAT
20polysaccharide32 8.7RECK, SELL, SELP, CD14, C3, PRNP
21aprotinin32 9 9 10.6PLCG1, PLAT, F10, MB, SELP, VWF
22histamine32 18 9.6SELL, F10, TFRC, PLAU, PLAT, VWF
23heparin32 9 18 9 11.6PIK3C2A, RECK, VWF, LBR, CD55, ANXA5
24citrate32 8.5SELP, TFRC, HP, F10, PIK3C2A, MB
25glutamine32 8.4TFRC, VWF, CD14, MB, F10, HPRT1
26atorvastatin32 34 9 18 9 12.3SELL, VWF, SELP, CD59, CD55, PLAU
27h2o232 8.3ANXA5, PRNP, PLCG1, VWF, HP, F10
28dexamethasone32 42 34 9 9 12.3HPRT1, HP, VWF, ANXA5, SELL, CD55
29aspartate32 8.3PLAU, HLA-DQB1, HLA-DQA1, HP, F10, MB
30epinephrine32 9 18 9 11.2PLAU, MB, PIK3C2A, SELL, SELP, LBR
31doxorubicin32 34 9 9 11.1ANXA5, HMGA2, PLAU, TFRC, RECK, PIK3C2A
32cysteine32 8.1CD14, RECK, MB, C3, PLAT, TFRC
33homocysteine32 18 9.0TCN2, PLAT, HP, CD14, MTHFR, PIK3C2A
34lipid32 7.9PLAUR, CD55, CD59, CD14, CD58, LBR
35fibrinogen32 7.8PLAT, SELP, RECK, PIK3C2A, ANXA5, C3
36paraffin32 7.7VWF, SELL, CD14, HMGA2, MB, PRNP
37phosphatidylinositol32 7.7CD55, CD59, CD14, CD58, PIK3C2A, PIGA
38adenylate32 7.5HP, F10, MB, SELP, HPRT1, HLA-A
39cisplatin32 34 9 9 10.4PLAUR, MB, CD55, CD58, F10, MTHFR
40retinoic acid32 42 18 9.3SELP, SELL, VWF, KIR2DS4, CD14, BST1
41oxygen32 18 8.0C3, G6PD, KLRK1, HLA-B, ANXA5, MB
42alanine32 7.0PIK3C2A, CD55, CD14, MTHFR, VWF, TFRC
43lactate32 6.9TFRC, C3, G6PD, EPO, PLAU, SELP
44cholesterol32 9 18 9 9.8C3, PRNP, MTHFR, LBR, PLAT, PIK3C2A
45vegf32 6.8ANXA5, MB, CD55, PLCG1, CD14, SELP
46cyclosporin a32 42 7.7EPO, PLCG1, CSF3, PIK3C2A, HLA-A, HP
47serine32 6.5G6PD, LBR, HLA-B, PLAU, HPRT1, VWF
48creatinine32 6.1CD55, MTHFR, SELP, SELL, VWF, PIK3C2A
49arginine32 5.8HLA-A, PRNP, TFRC, KLRK1, HLA-B, HLA-DQA1
50tyrosine32 5.3SELP, SEMA7A, LBR, CD59, CD55, FCGR3A

GO Terms for genes affiliated with Hemoglobinuria

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Sources:
12Gene Ontology
See all sources

Cellular components related to hemoglobinuria according to GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1extrinsic to membraneGO:01989810.1PRNP, GFRA1, PLAUR, BST1
2MHC class I protein complexGO:0426129.8HLA-A, HLA-B, HLA-C
3anchored to membraneGO:0312259.6RECK, PRNP, GFRA1, ACHE, PLAUR, FCGR3B
4MHC class II protein complexGO:0426139.6HLA-DQA1, HLA-DQB1, HLA-DRB1
5Golgi membraneGO:0001399.3HLA-DQB1, HLA-DQA1, B3GNT3
6integral to lumenal side of endoplasmic reticulum membraneGO:0715569.2HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-C, HLA-B, HLA-A
7ER to Golgi transport vesicle membraneGO:0125079.2HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-C, HLA-B, HLA-A
8external side of plasma membraneGO:0098978.6HLA-DRB1, ANXA5, FCGR3A, SEMA7A, SELP, SELL
9extracellular spaceGO:0056158.1TCN2, CSF3, C3, C8B, EPO, PLG
10integral to plasma membraneGO:0058877.7HLA-C, HLA-DQA1, HLA-DRB1, PLAUR, KLRC2, C9
11extracellular regionGO:0055767.1PLAUR, PLG, C9, ACHE, TFRC, C3
12plasma membraneGO:0058865.4PLCG1, NRAS, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-C

Biological processes related to hemoglobinuria according to GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1C-terminal protein lipidationGO:00650110.4PLAUR, PIGH, PIGF, PIGA
2GPI anchor biosynthetic processGO:00650610.2PIGA, PIGF, PIGH
3preassembly of GPI anchor in ER membraneGO:01625410.1PIGA, PIGF, PIGH
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independentGO:00248010.0HLA-A, HLA-B, HLA-C
5complement activation, alternative pathwayGO:0069579.9C8B, C3, C9
6fibrinolysisGO:0427309.9PLG, PLAUR, PLAU, PLAT
7leukocyte migrationGO:0509009.8PLCG1, NRAS, CD58, SELP, SELL
8complement activation, classical pathwayGO:0069589.8CD55, C9, C3, C8B
9post-translational protein modificationGO:0436879.7PLAUR, F10, B3GNT3, PIGH, PIGF, PIGA
10detection of bacteriumGO:0160459.6HLA-DRB1, HLA-B, HLA-A
11cytolysisGO:0198359.4C8B, C9, HPRT1
12interferon-gamma-mediated signaling pathwayGO:0603339.3HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-C, HLA-B, HLA-A
13regulation of immune responseGO:0507769.1C3, HLA-C, HLA-B, HLA-A, FCGR3A, SELL
14cytokine-mediated signaling pathwayGO:0192219.1CSF3, PLCG1, HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-C
15blood coagulationGO:0075968.3PLAT, PLCG1, PLAU, PLAUR, PLG, C9
16immune responseGO:0069557.8SEMA7A, C8B, C3, CSF3, HLA-DRB1, HLA-DQB1

Molecular functions related to hemoglobinuria according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class I receptor activityGO:0323939.8HLA-A, HLA-B, HLA-C
2MHC class II receptor activityGO:0323959.4HLA-DQA1, HLA-DQB1, HLA-DRB1

Sources for Hemoglobinuria

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2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
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