MCID: HMG002
MIFTS: 52

Hemoglobinuria malady

Immune diseases, Blood diseases, Nephrological diseases categories
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Summaries for Hemoglobinuria

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Wikipedia:65 In medicine, hemoglobinuria or haemoglobinuria is a condition in which the oxygen transport protein... more...

MalaCards based summary: Hemoglobinuria is related to aplastic anemia and myelodysplastic syndromes. An important gene associated with Hemoglobinuria is PIGA (phosphatidylinositol glycan anchor biosynthesis, class A), and among its related pathways are Complement Pathway and Post-translational modification- synthesis of GPI-anchored proteins. The compounds alemtuzumab and tuberculin have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and kidney, and related mouse phenotypes are renal/urinary system and hematopoietic system.

Aliases & Classifications for Hemoglobinuria

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Sources:
8Disease Ontology, 44Novoseek, 62UMLS, 27ICD9CM, 34MeSH, 57SNOMED-CT, 39NCIt, 25ICD10
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Related Diseases for Hemoglobinuria

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Diseases related to Hemoglobinuria via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 154)
idRelated DiseaseScoreTop Affiliating Genes
1aplastic anemia31.2PIGA, CD59, CD55
2myelodysplastic syndromes30.8CD59, PIGA, CD55
3pancytopenia30.6CD55, HP
4malaria30.6HP
5hemolytic anemia30.2CD59, PIGA, HP, CD55
6myocardial infarction30.1CD59, CD55, CD14
7systemic lupus erythematosus30.1CD55, CD59, FCGR3B
8chronic lymphocytic leukemia30.1CD58, CD59, CD55
9nephritis30.0FCGR3B, CD55
10autoimmune hemolytic anemia30.0CD55, CD59, HP, PIGA
11ischemia29.9HP, CD14, CD59, CD55
12non-hodgkin lymphoma29.9CD14, CD59, CD55
13sepsis29.8CD14, CD55, FCGR3B
14acute leukemia29.7CD14, PLAUR, CD58
15leukemia29.0PIGA, FCGR3B, HP, PLAUR, CD58, CD14
16paroxysmal nocturnal hemoglobinuria, somatic28.8CD14, PIGA, CD55, FCGR3B, HP, CD59
17paroxysmal nocturnal hemoglobinuria11.3
18paroxysmal cold hemoglobinuria10.8
19hemoglobinemia10.5
20thrombocytopenia10.4
21cerebritis10.4
22membranous glomerulonephritis10.3HP, CD59
23purpura10.3
24plasmodium falciparum malaria10.3HP, CD55
25hepatitis10.2
26heparin-induced thrombocytopenia10.2
27venous thrombosis10.2
28lymphopenia10.2CD55, CD59
29uveal melanoma10.2CD59, CD55
30pulmonary tuberculosis10.2CD14, HP
31follicular lymphoma10.2CD59, CD55
32retinitis10.2
33gastritis10.2CD55, CD59
34galactosemia10.2HP
35berger disease10.2CD55, CD14
36peritonitis10.1FCGR3B, CD14
37nephrotic syndrome10.1CD14, HP
38hematopoietic stem cell transplantation10.1
39myelofibrosis10.1
40blackwater fever10.1
41hemosiderosis10.1
42vasculitis10.1FCGR3B, CD14
43chronic myeloid leukemia10.0CD55, FCGR3B, CD59
44ulcerative colitis10.0CD55, CD59, CD14
45acute lymphoblastic leukemia10.0
46hepatocellular carcinoma10.0
47multiple myeloma10.0
48neutropenia10.0
49antiphospholipid syndrome10.0
50splenic infarction10.0

Graphical network of the top 20 diseases related to Hemoglobinuria:



Diseases related to hemoglobinuria

Symptoms for Hemoglobinuria

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Drugs & Therapeutics for Hemoglobinuria

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Drug clinical trials:

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Search NIH Clinical Center for Hemoglobinuria

Genetic Tests for Hemoglobinuria

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Anatomical Context for Hemoglobinuria

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MalaCards organs/tissues related to Hemoglobinuria:

32
Bone, Bone marrow, Kidney, T cells, Testes, Neutrophil, Liver, Monocytes, Heart, Endothelial, Whole blood, Spleen, Smooth muscle, Lung, Myeloid, Nk cells, B cells

Animal Models for Hemoglobinuria or affiliated genes

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MGI Mouse Phenotypes related to Hemoglobinuria:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.4HP, PLAUR, CD59, CD55
2MP:00053977.2PIGA, HP, PLAUR, CD14, CD59, CD55

Publications for Hemoglobinuria

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Articles related to Hemoglobinuria:

(show top 50)    (show all 709)
idTitleAuthorsYear
1
Two case studies and a review of paroxysmal cold hemoglobinuria. (25051079)
2014
2
Paroxysmal nocturnal hemoglobinuria. (25237200)
2014
3
A Systemic Lupus Erythematosus Patient with Isolated Neutropenia and Diminished Expression of CD55 and CD59 Similar to Paroxysmal Nocturnal Hemoglobinuria. (25330534)
2014
4
Paroxysmal nocturnal hemoglobinuria: a red clot syndrome. (24200143)
2014
5
Laboratory tests for paroxysmal nocturnal hemoglobinuria (PNH). (24127129)
2013
6
Paroxysmal nocturnal hemoglobinuria and the complement system: recent insights and novel anticomplement strategies. (22990701)
2013
7
Diagnosis of paroxysmal nocturnal hemoglobinuria in peripheral blood and bone marrow with six-color flow cytometry. (23387491)
2013
8
Long-term remission of paroxysmal nocturnal hemoglobinuria following chemoimmunotherapy for non-Hodgkin lymphoma. (22402359)
2012
9
A case report of concomitant paroxysmal nocturnal hemoglobinuria and heterozygous I^-thalassemia. (20556389)
2011
10
Safety and efficacy of the terminal complement inhibitor eculizumab in Japanese patients with paroxysmal nocturnal hemoglobinuria: the AEGIS clinical trial. (21222185)
2011
11
Managing a pregnant patient with paroxysmal nocturnal hemoglobinuria in the era of eculizumab. (19954846)
2010
12
The management of paroxysmal nocturnal hemoglobinuria: recent advances in diagnosis and treatment and new hope for patients. (19171207)
2009
13
Eculizumab opens a new era of treatment for paroxysmal nocturnal hemoglobinuria. (21082989)
2009
14
A case of paroxysmal nocturnal hemoglobinuria presenting with intra-abdominal bleeding due to splenic rupture, developing renal infarct. (18479304)
2008
15
The role of flow cytometry in the diagnosis of paroxysmal nocturnal hemoglobinuria in the clinical laboratory. (17658408)
2007
16
Recent advances in biological and clinical aspects of paroxysmal nocturnal hemoglobinuria. (16926130)
2006
17
Heterogeneity in the molecular pathogenesis of paroxysmal nocturnal hemoglobinuria (PNH) syndromes and expansion mechanism of a PNH clone. (16926129)
2006
18
Accelerated telomere shortening in glycosylphosphatidylinositol (GPI)-negative compared with GPI-positive granulocytes from patients with paroxysmal nocturnal hemoglobinuria (PNH) detected by proaerolysin flow-FISH. (15811960)
2005
19
Acute lymphoblastic leukemic transformation in a patient with chronic idiopathic myelofibrosis and paroxysmal nocturnal hemoglobinuria: a case report and review of the literature. (15628917)
2005
20
Diazepam-binding inhibitor-related protein 1: a candidate autoantigen in acquired aplastic anemia patients harboring a minor population of paroxysmal nocturnal hemoglobinuria-type cells. (15217832)
2004
21
Paroxysmal nocturnal hemoglobinuria in pregnancy. (14616248)
2003
22
Laboratory diagnosis of paroxysmal nocturnal hemoglobinuria. (14584753)
2003
23
Images in cardiovascular medicine. Recurrent myocardial infarction in a patient with paroxysmal nocturnal hemoglobinuria. (14517154)
2003
24
Polyclonal hematopoiesis maintained in patients with bone marrow failure harboring a minor population of paroxysmal nocturnal hemoglobinuria-type cells. (12676778)
2003
25
Cardiac surgery in a patient with paroxysmal nocturnal hemoglobinuria. (12161376)
2002
26
Murine models of paroxysmal nocturnal hemoglobinuria. (12095954)
2002
27
Paroxysmal nocturnal hemoglobinuria with no evidence of hemolysis presenting as Budd-Chiari syndrome. (11215746)
2000
28
Aplastic anemia and paroxysmal nocturnal hemoglobinuria: a follow-up study of the glycosylphosphatidylinositol-anchored proteins defect. (11920198)
2000
29
Acute onset hemoglobinemia and/or hemoglobinuria and sequelae following Rh(o)(D) immune globulin intravenous administration in immune thrombocytopenic purpura patients. (10753830)
2000
30
N-RAS gene mutation in patients with aplastic anemia and aplastic anemia/ paroxysmal nocturnal hemoglobinuria during evolution to clonal disease. (10627475)
2000
31
Analysis of T cells in paroxysmal nocturnal hemoglobinuria provides direct evidence that thymic T-cell production declines with age. (10515882)
1999
32
A case of pulmonary embolism caused by paroxysmal nocturnal hemoglobinuria. (9559419)
1998
33
Paroxysmal nocturnal hemoglobinuria and renal failure. (18408291)
1998
34
Delayed hemolytic transfusion reaction and paroxysmal cold hemoglobinuria: an unusual association. (15387783)
1997
35
Resistance to apoptosis caused by PIG-A gene mutations in paroxysmal nocturnal hemoglobinuria. (9238050)
1997
36
Mechanism of intravascular hemolysis in paroxysmal nocturnal hemoglobinuria (PNH). (8813092)
1996
37
Natural history of paroxysmal nocturnal hemoglobinuria. (7566002)
1995
38
High-dose recombinant human erythropoietin and low-dose corticosteroids for treatment of anemia in paroxysmal nocturnal hemoglobinuria. (8023644)
1994
39
Expression of GPI-anchor proteins during the differentiation from hematopoietic progenitors in patients with paroxysmal nocturnal hemoglobinuria]. (8028180)
1994
40
Abnormalities of PIG-A transcripts in granulocytes from patients with paroxysmal nocturnal hemoglobinuria. (8272086)
1994
41
Paroxysmal nocturnal hemoglobinuria associated with venous thrombosis and papillary endothelial hyperplasia presenting as ulcerated duodenal mass. (8060237)
1994
42
Paroxysmal nocturnal hemoglobinuria. Diagnosis aided by a monoclonal antibody directed against the decay accelerating factor glycoprotein]. (7685522)
1993
43
Deficiency of phosphatidylinositol-linked membrane proteins on erythrocytes of different subpopulations in paroxysmal nocturnal hemoglobinuria. (7691484)
1993
44
The receptor for urokinase-type plasminogen activator is deficient on peripheral blood leukocytes in patients with paroxysmal nocturnal hemoglobinuria. (1312369)
1992
45
Myeloblastic leukemoid reaction in paroxysmal nocturnal hemoglobinuria associated with myelodysplasia. (1585775)
1992
46
Two cases of paroxysmal cold hemoglobinuria with a Donath-Landsteiner antibody reactive by the indirect antiglobulin test using anti-IgG. (1996489)
1991
47
Deficiency of glycosyl-phosphatidylinositol-linked membrane glycoproteins of leukocytes in paroxysmal nocturnal hemoglobinuria, description of a new diagnostic cytofluorometric assay. (2145990)
1990
48
Paroxysmal nocturnal hemoglobinuria: termination in acute monocytic leukemia and reappearance after chemotherapy with N4-palmitoyl-1-beta-D-arabinofuranosylcytosine (PL-AC) and vincristine. (3475490)
1987
49
Erythrophagocytosis by segmented neutrophils in paroxysmal cold hemoglobinuria. (6731359)
1984
50
Paroxysmal cold hemoglobinuria with positive treponema immobilization test, report of case. (13471657)
1957

Variations for Hemoglobinuria

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Expression for genes affiliated with Hemoglobinuria

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Expression patterns in normal tissues for genes affiliated with Hemoglobinuria

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Pathways for genes affiliated with Hemoglobinuria

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Pathways related to Hemoglobinuria according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Immune response Alternative complement pathway60
Immune response Lectin Induced complement pathway60
Immune response Classic complement pathway60
9.6CD55, CD59
2
Show member pathways
9.3PIGA, PLAUR
39.3PLAUR, HP
49.1CD55, CD59, CD14
5
Show member pathways
Complement Activation, Classical Pathway37
Complement and Coagulation Cascades37
8.8CD55, CD59, PLAUR

Compounds for genes affiliated with Hemoglobinuria

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Compounds related to Hemoglobinuria according to GeneCards/GeneDecks:

(show top 50)    (show all 56)
idCompoundScoreTop Affiliating Genes
1alemtuzumab44 1110.9FCGR3B, PIGA
2tuberculin449.9HP, CD14
3alefacept44 1110.7CD58, FCGR3B
4anaphylatoxin449.7HP, CD59, CD55
5methylcellulose449.6CD14, CD59, PIGA
6sialic acid449.6HP, CD59, CD55
7fitc449.5CD55, CD14, CD59
8fluorochrome449.4CD14, PLAUR
9polyacrylamide449.4CD14, CD55, HP
10phospholipid449.4HP, CD55, CD59
11hirudin449.3PLAUR, CD55
12pentoxifylline44 1110.3HP, CD14
13kininogen449.3HP, PLAUR
14cytochalasin b449.2PLAUR, FCGR3B
15n-acetylglucosamine449.2PLAUR, CD14, PIGA
16aspirin44 50 28 2412.2CD59, HP, PLAUR
17neopterin449.2PLAUR, CD14, HP
18rituximab44 50 1111.2CD59, HP, FCGR3B, CD55
19p002449.1HP, PLAUR, CD14
20cyclosporin a44 28 6111.1CD55, CD14, HP, CD59
21endotoxin449.1PLAUR, HP, CD14
22n-formylmethionyl-leucylphenylalanine449.1CD55, PLAUR, FCGR3B
23lactate449.1CD14, HP, CD59
24hyaluronic acid44 2410.0HP, PLAUR, CD58
25polysaccharide449.0CD14, CD55, FCGR3B, HP
26vitamin d449.0PLAUR, HP, CD14
27fibrinogen449.0CD14, PLAUR, HP
28atp44 2810.0CD14, HP, CD55, CD59
29butyrate448.9PLAUR, CD14, CD55
30actinomycin d448.9PLAUR, CD55, HP
31iron44 249.8CD55, HP, PLAUR, CD59
32pge2448.8HP, PLAUR, CD14
33glycolipid448.7CD55, CD59, CD14, PLAUR
34creatinine448.7CD14, HP, PLAUR, CD55
35heparin44 28 24 1111.7CD55, CD14, PLAUR, HP
36vegf448.6CD14, CD55, HP, PLAUR
37superoxide44 249.6CD14, PLAUR, FCGR3B, CD59
38alanine448.6CD55, CD14, PLAUR, HP
39carbohydrates448.6PLAUR, HP, CD58, CD14
40cysteine448.5CD14, CD55, HP, PLAUR
41sucrose44 24 1110.3CD55, CD59, HP, CD14, PLAUR
42cholesterol44 28 24 1111.3CD59, PLAUR, HP, CD55, CD14
43glucose448.3CD55, CD59, CD14, PLAUR, HP
44tyrosine448.2PLAUR, HP, FCGR3B, CD59, CD55
45fmlp448.2CD55, FCGR3B, CD59, CD14, PLAUR
46serine448.1PLAUR, CD55, FCGR3B, HP, CD14
47dexamethasone44 50 28 1111.1CD58, CD55, CD14, HP, PLAUR
48calcium44 50 24 1110.8PLAUR, CD14, CD59, HP, CD55, FCGR3B
49phosphatidylinositol447.2PLAUR, CD58, FCGR3B, PIGA, CD14, CD59
50lipid447.2CD58, HP, FCGR3B, PLAUR, CD14, CD59

GO Terms for genes affiliated with Hemoglobinuria

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Cellular components related to Hemoglobinuria according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:0099868.4CD58, CD14, CD59, CD55
2extracellular vesicular exosomeGO:0700627.8HP, CD58, CD14, CD59, CD55
3anchored component of membraneGO:0312257.6CD55, CD14, CD58, PLAUR, FCGR3B
4extracellular regionGO:0055767.4FCGR3B, HP, PLAUR, CD14, CD59, CD55
5plasma membraneGO:0058867.1CD55, CD59, CD14, CD58, PLAUR, FCGR3B

Biological processes related to Hemoglobinuria according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of complement activationGO:0304499.5CD55, CD59
2C-terminal protein lipidationGO:0065019.0PLAUR, PIGA
3blood coagulationGO:0075968.6CD59, CD58, PLAUR

Molecular functions related to Hemoglobinuria according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055156.9CD55, CD59, CD14, CD58, PLAUR, HP

Products for genes affiliated with Hemoglobinuria

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Sources for Hemoglobinuria

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet