MCID: HMG002
MIFTS: 52

Hemoglobinuria malady

Immune diseases, Blood diseases, Nephrological diseases categories

Summaries for Hemoglobinuria

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66Wikipedia, 34MalaCards
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Wikipedia:66 In medicine, hemoglobinuria or haemoglobinuria is a condition in which the oxygen transport protein... more...

MalaCards: Hemoglobinuria, also known as haemoglobinuria, is related to paroxysmal nocturnal hemoglobinuria and aplastic anemia. An important gene associated with Hemoglobinuria is PIGA (phosphatidylinositol glycan anchor biosynthesis, class A), and among its related pathways are Complement Pathway and Post-translational modification- synthesis of GPI-anchored proteins. The compounds alemtuzumab and tuberculin have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and kidney, and related mouse phenotypes are renal/urinary system and hematopoietic system.

Aliases & Classifications for Hemoglobinuria

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9Disease Ontology, 46Novoseek, 63UMLS, 41NCIt, 59SNOMED-CT, 36MeSH, 28ICD9CM, 26ICD10
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Related Diseases for Hemoglobinuria

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18GeneCards, 19GeneDecks
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Diseases related to Hemoglobinuria via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 163)
idRelated DiseaseScoreTop Affiliating Genes
1paroxysmal nocturnal hemoglobinuria31.5CD14, PIGA, CD55, FCGR3B, HP, CD59
2aplastic anemia31.0PIGA, CD59, CD55
3myelodysplastic syndromes30.7CD59, PIGA, CD55
4leukemia30.3PIGA, FCGR3B, HP, PLAUR, CD58, CD14
5pancytopenia30.3CD55, HP
6hemolytic anemia30.3CD59, PIGA, HP, CD55
7myocardial infarction30.0CD59, CD55, CD14
8chronic lymphocytic leukemia30.0CD58, CD59, CD55
9autoimmune hemolytic anemia30.0CD55, CD59, HP, PIGA
10ischemia30.0HP, CD14, CD59, CD55
11malaria30.0HP
12acute leukemia30.0CD14, PLAUR, CD58
13nephritis29.9FCGR3B, CD55
14non-hodgkin lymphoma29.8CD14, CD59, CD55
15systemic lupus erythematosus29.8CD55, CD59, FCGR3B
16sepsis29.8CD14, CD55, FCGR3B
17paroxysmal cold hemoglobinuria10.8
18hemoglobinemia10.4
19cerebritis10.3
20thrombocytopenia10.3
21paroxysmal nocturnal hemoglobinuria, somatic10.3
22purpura10.3
23heparin-induced thrombocytopenia10.2
24venous thrombosis10.2
25hepatitis10.2
26retinitis10.2
27hemosiderosis10.1
28blackwater fever10.1
29myelofibrosis10.1
30eclampsia10.1
31pre-eclampsia10.1
32purpura fulminans10.1
33membranous glomerulonephritis10.1HP, CD59
34plasmodium falciparum malaria10.1HP, CD55
35lymphopenia10.1CD55, CD59
36intraocular melanoma10.1CD59, CD55
37pulmonary tuberculosis10.1CD14, HP
38follicular lymphoma10.0CD59, CD55
39gastritis10.0CD55, CD59
40galactosemia10.0HP
41iga glomerulonephritis10.0CD55, CD14
42peritonitis10.0FCGR3B, CD14
43nephrotic syndrome10.0CD14, HP
44antiphospholipid syndrome10.0
45fanconi syndrome10.0
46splenic infarction10.0
47hepatic vein thrombosis10.0
48patent foramen ovale10.0
49cholangitis10.0
50hepatocellular carcinoma10.0

Graphical network of the top 20 diseases related to Hemoglobinuria:



Diseases related to hemoglobinuria

Symptoms for Hemoglobinuria

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Drugs & Therapeutics for Hemoglobinuria

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Hemoglobinuria

Drug clinical trials:

Search ClinicalTrials for Hemoglobinuria

Search NIH Clinical Center for Hemoglobinuria

Search CenterWatch for Hemoglobinuria

Genetic Tests for Hemoglobinuria

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Anatomical Context for Hemoglobinuria

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34MalaCards
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MalaCards organs/tissues related to Hemoglobinuria:

34
Bone, Bone marrow, Kidney, T cells, Testes, Liver, Monocytes, Heart, Endothelial, Whole blood, Smooth muscle, Myeloid, Lung, Nk cells, Spleen, B cells

Animal Models for Hemoglobinuria or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Hemoglobinuria:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.4HP, PLAUR, CD59, CD55
2MP:00053977.2PIGA, HP, PLAUR, CD14, CD59, CD55

Publications for Hemoglobinuria

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53PubMed
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Articles related to Hemoglobinuria:

(show top 50)    (show all 687)
idTitleAuthorsYear
1
Paroxysmal nocturnal hemoglobinuria: a red clot syndrome. (24200143)
2014
2
Laboratory tests for paroxysmal nocturnal hemoglobinuria (PNH). (24127129)
2013
3
Paroxysmal nocturnal hemoglobinuria and the complement system: recent insights and novel anticomplement strategies. (22990701)
2013
4
Diagnosis of paroxysmal nocturnal hemoglobinuria in peripheral blood and bone marrow with six-color flow cytometry. (23387491)
2013
5
Long-term remission of paroxysmal nocturnal hemoglobinuria following chemoimmunotherapy for non-Hodgkin lymphoma. (22402359)
2012
6
A case report of concomitant paroxysmal nocturnal hemoglobinuria and heterozygous I^-thalassemia. (20556389)
2011
7
Safety and efficacy of the terminal complement inhibitor eculizumab in Japanese patients with paroxysmal nocturnal hemoglobinuria: the AEGIS clinical trial. (21222185)
2011
8
Thrombosis in patients with paroxysmal nocturnal hemoglobinuria. (21455865)
2011
9
Managing a pregnant patient with paroxysmal nocturnal hemoglobinuria in the era of eculizumab. (19954846)
2010
10
The management of paroxysmal nocturnal hemoglobinuria: recent advances in diagnosis and treatment and new hope for patients. (19171207)
2009
11
Eculizumab opens a new era of treatment for paroxysmal nocturnal hemoglobinuria. (21082989)
2009
12
A case of paroxysmal nocturnal hemoglobinuria presenting with intra-abdominal bleeding due to splenic rupture, developing renal infarct. (18479304)
2008
13
The role of flow cytometry in the diagnosis of paroxysmal nocturnal hemoglobinuria in the clinical laboratory. (17658408)
2007
14
Recent advances in biological and clinical aspects of paroxysmal nocturnal hemoglobinuria. (16926130)
2006
15
Heterogeneity in the molecular pathogenesis of paroxysmal nocturnal hemoglobinuria (PNH) syndromes and expansion mechanism of a PNH clone. (16926129)
2006
16
Accelerated telomere shortening in glycosylphosphatidylinositol (GPI)-negative compared with GPI-positive granulocytes from patients with paroxysmal nocturnal hemoglobinuria (PNH) detected by proaerolysin flow-FISH. (15811960)
2005
17
Acute lymphoblastic leukemic transformation in a patient with chronic idiopathic myelofibrosis and paroxysmal nocturnal hemoglobinuria: a case report and review of the literature. (15628917)
2005
18
Diazepam-binding inhibitor-related protein 1: a candidate autoantigen in acquired aplastic anemia patients harboring a minor population of paroxysmal nocturnal hemoglobinuria-type cells. (15217832)
2004
19
Paroxysmal nocturnal hemoglobinuria in pregnancy. (14616248)
2003
20
Laboratory diagnosis of paroxysmal nocturnal hemoglobinuria. (14584753)
2003
21
Images in cardiovascular medicine. Recurrent myocardial infarction in a patient with paroxysmal nocturnal hemoglobinuria. (14517154)
2003
22
Polyclonal hematopoiesis maintained in patients with bone marrow failure harboring a minor population of paroxysmal nocturnal hemoglobinuria-type cells. (12676778)
2003
23
Cardiac surgery in a patient with paroxysmal nocturnal hemoglobinuria. (12161376)
2002
24
Murine models of paroxysmal nocturnal hemoglobinuria. (12095954)
2002
25
Phenotypes and phosphatidylinositol glycan-class A gene abnormalities during cell differentiation and maturation from precursor cells to mature granulocytes in patients with paroxysmal nocturnal hemoglobinuria. (12411324)
2002
26
Paroxysmal nocturnal hemoglobinuria with no evidence of hemolysis presenting as Budd-Chiari syndrome. (11215746)
2000
27
Aplastic anemia and paroxysmal nocturnal hemoglobinuria: a follow-up study of the glycosylphosphatidylinositol-anchored proteins defect. (11920198)
2000
28
Acute onset hemoglobinemia and/or hemoglobinuria and sequelae following Rh(o)(D) immune globulin intravenous administration in immune thrombocytopenic purpura patients. (10753830)
2000
29
N-RAS gene mutation in patients with aplastic anemia and aplastic anemia/ paroxysmal nocturnal hemoglobinuria during evolution to clonal disease. (10627475)
2000
30
Analysis of T cells in paroxysmal nocturnal hemoglobinuria provides direct evidence that thymic T-cell production declines with age. (10515882)
1999
31
A case of pulmonary embolism caused by paroxysmal nocturnal hemoglobinuria. (9559419)
1998
32
Paroxysmal nocturnal hemoglobinuria and renal failure. (18408291)
1998
33
Delayed hemolytic transfusion reaction and paroxysmal cold hemoglobinuria: an unusual association. (15387783)
1997
34
Resistance to apoptosis caused by PIG-A gene mutations in paroxysmal nocturnal hemoglobinuria. (9238050)
1997
35
Mechanism of intravascular hemolysis in paroxysmal nocturnal hemoglobinuria (PNH). (8813092)
1996
36
Natural history of paroxysmal nocturnal hemoglobinuria. (7566002)
1995
37
High-dose recombinant human erythropoietin and low-dose corticosteroids for treatment of anemia in paroxysmal nocturnal hemoglobinuria. (8023644)
1994
38
Expression of GPI-anchor proteins during the differentiation from hematopoietic progenitors in patients with paroxysmal nocturnal hemoglobinuria]. (8028180)
1994
39
Abnormalities of PIG-A transcripts in granulocytes from patients with paroxysmal nocturnal hemoglobinuria. (8272086)
1994
40
Paroxysmal nocturnal hemoglobinuria associated with venous thrombosis and papillary endothelial hyperplasia presenting as ulcerated duodenal mass. (8060237)
1994
41
Paroxysmal nocturnal hemoglobinuria. Diagnosis aided by a monoclonal antibody directed against the decay accelerating factor glycoprotein]. (7685522)
1993
42
Deficiency of phosphatidylinositol-linked membrane proteins on erythrocytes of different subpopulations in paroxysmal nocturnal hemoglobinuria. (7691484)
1993
43
The receptor for urokinase-type plasminogen activator is deficient on peripheral blood leukocytes in patients with paroxysmal nocturnal hemoglobinuria. (1312369)
1992
44
Myeloblastic leukemoid reaction in paroxysmal nocturnal hemoglobinuria associated with myelodysplasia. (1585775)
1992
45
Two cases of paroxysmal cold hemoglobinuria with a Donath-Landsteiner antibody reactive by the indirect antiglobulin test using anti-IgG. (1996489)
1991
46
Deficiency of glycosyl-phosphatidylinositol-linked membrane glycoproteins of leukocytes in paroxysmal nocturnal hemoglobinuria, description of a new diagnostic cytofluorometric assay. (2145990)
1990
47
Paroxysmal nocturnal hemoglobinuria: termination in acute monocytic leukemia and reappearance after chemotherapy with N4-palmitoyl-1-beta-D-arabinofuranosylcytosine (PL-AC) and vincristine. (3475490)
1987
48
Erythrophagocytosis by segmented neutrophils in paroxysmal cold hemoglobinuria. (6731359)
1984
49
Paroxysmal cold hemoglobinuria with positive treponema immobilization test, report of case. (13471657)
1957
50
Paroxysmal cold hemoglobinuria; report of two cases. (18858906)
1948

Variations for Hemoglobinuria

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Expression for genes affiliated with Hemoglobinuria

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hemoglobinuria

Search GEO for disease gene expression data for Hemoglobinuria.

Pathways for genes affiliated with Hemoglobinuria

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51PathCards, 54QIAGEN, 61Thomson Reuters, 56Reactome, 58SinoBiological, 31KEGG, 39NCBI BioSystems Database
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Pathways related to Hemoglobinuria according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Immune response Alternative complement pathway61
Immune response Lectin Induced complement pathway61
Immune response Classic complement pathway61
9.6CD59, CD55
2
Show member pathways
9.3PLAUR, PIGA
39.3PLAUR, HP
49.1CD14, CD55, CD59
5
Show member pathways
Complement Activation, Classical Pathway39
Complement and Coagulation Cascades39
8.8PLAUR, CD55, CD59

Compounds for genes affiliated with Hemoglobinuria

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46Novoseek, 12DrugBank, 52PharmGKB, 30IUPHAR, 25HMDB, 62Tocris Bioscience
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Compounds related to Hemoglobinuria according to GeneCards/GeneDecks:

(show top 50)    (show all 56)
idCompoundScoreTop Affiliating Genes
1alemtuzumab46 1210.9FCGR3B, PIGA
2tuberculin469.9HP, CD14
3alefacept46 1210.7CD58, FCGR3B
4anaphylatoxin469.7HP, CD59, CD55
5methylcellulose469.6CD14, CD59, PIGA
6sialic acid469.6HP, CD59, CD55
7fitc469.5CD55, CD14, CD59
8fluorochrome469.4CD14, PLAUR
9polyacrylamide469.4CD14, CD55, HP
10phospholipid469.4HP, CD55, CD59
11hirudin469.3PLAUR, CD55
12pentoxifylline46 1210.3HP, CD14
13kininogen469.3HP, PLAUR
14cytochalasin b469.2PLAUR, FCGR3B
15n-acetylglucosamine469.2PLAUR, CD14, PIGA
16aspirin46 52 30 2512.2CD59, HP, PLAUR
17neopterin469.2PLAUR, CD14, HP
18rituximab46 52 1211.2CD59, HP, FCGR3B, CD55
19p002469.1HP, PLAUR, CD14
20cyclosporin a46 30 6211.1CD55, CD14, HP, CD59
21endotoxin469.1PLAUR, HP, CD14
22n-formylmethionyl-leucylphenylalanine469.1CD55, PLAUR, FCGR3B
23lactate469.1CD14, HP, CD59
24hyaluronic acid46 2510.0HP, PLAUR, CD58
25polysaccharide469.0CD14, CD55, FCGR3B, HP
26vitamin d469.0PLAUR, HP, CD14
27fibrinogen469.0CD14, PLAUR, HP
28atp46 3010.0CD14, HP, CD55, CD59
29butyrate468.9PLAUR, CD14, CD55
30actinomycin d468.9PLAUR, CD55, HP
31iron46 259.8CD55, HP, PLAUR, CD59
32pge2468.8HP, PLAUR, CD14
33glycolipid468.7CD55, CD59, CD14, PLAUR
34creatinine468.7CD14, HP, PLAUR, CD55
35heparin46 30 25 1211.7CD55, CD14, PLAUR, HP
36vegf468.6CD14, CD55, HP, PLAUR
37superoxide46 259.6CD14, PLAUR, FCGR3B, CD59
38alanine468.6CD55, CD14, PLAUR, HP
39carbohydrates468.6PLAUR, HP, CD58, CD14
40cysteine468.5CD14, CD55, HP, PLAUR
41sucrose46 25 1210.3CD55, CD59, HP, CD14, PLAUR
42cholesterol46 30 25 1211.3CD59, PLAUR, HP, CD55, CD14
43glucose468.3CD55, CD59, CD14, PLAUR, HP
44tyrosine468.2PLAUR, HP, FCGR3B, CD59, CD55
45fmlp468.2CD55, FCGR3B, CD59, CD14, PLAUR
46serine468.1PLAUR, CD55, FCGR3B, HP, CD14
47dexamethasone46 52 30 1211.1CD58, CD55, CD14, HP, PLAUR
48calcium46 52 25 1210.8PLAUR, CD14, CD59, HP, CD55, FCGR3B
49phosphatidylinositol467.2PLAUR, CD58, FCGR3B, PIGA, CD14, CD59
50lipid467.2CD58, HP, FCGR3B, PLAUR, CD14, CD59

GO Terms for genes affiliated with Hemoglobinuria

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17Gene Ontology
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Cellular components related to Hemoglobinuria according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:0099868.4CD58, CD14, CD59, CD55
2extracellular vesicular exosomeGO:0700627.8CD58, CD14, CD59, CD55, HP
3anchored component of membraneGO:0312257.6FCGR3B, CD55, CD14, CD58, PLAUR
4extracellular regionGO:0055767.4CD55, FCGR3B, HP, PLAUR, CD14, CD59
5plasma membraneGO:0058867.1CD59, CD14, CD58, PLAUR, FCGR3B, CD55

Biological processes related to Hemoglobinuria according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of complement activationGO:0304499.5CD55, CD59
2C-terminal protein lipidationGO:0065019.0PLAUR, PIGA
3blood coagulationGO:0075968.6CD59, CD58, PLAUR

Molecular functions related to Hemoglobinuria according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055156.9CD55, CD59, CD14, CD58, PLAUR, HP

Products for genes affiliated with Hemoglobinuria

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Sources for Hemoglobinuria

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet