MCID: HMG002
MIFTS: 43

Hemoglobinuria malady

Immune diseases, Blood diseases categories

Aliases & Classifications for Hemoglobinuria

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Sources:
8Disease Ontology, 44Novoseek, 61UMLS, 56SNOMED-CT, 39NCIt, 33MeSH, 27ICD9CM, 25ICD10
See all sources

Summaries for Hemoglobinuria

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Wikipedia:64 In medicine, hemoglobinuria or haemoglobinuria is a condition in which the oxygen transport protein... more...

MalaCards based summary: Hemoglobinuria is related to aplastic anemia and myelodysplastic syndrome. An important gene associated with Hemoglobinuria is PIGA (phosphatidylinositol glycan anchor biosynthesis, class A), and among its related pathways are Complement Pathway and Post-translational modification- synthesis of GPI-anchored proteins. The compounds alemtuzumab and tuberculin have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and kidney, and related mouse phenotypes are renal/urinary system and hematopoietic system.

Related Diseases for Hemoglobinuria

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Diseases related to Hemoglobinuria via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 149)
idRelated DiseaseScoreTop Affiliating Genes
1aplastic anemia31.2CD55, CD59, PIGA
2myelodysplastic syndrome30.8CD55, CD59, PIGA
3malaria30.6HP
4pancytopenia30.5CD55, HP
5paroxysmal nocturnal hemoglobinuria30.3CD55, PIGA, FCGR3B, HP, PLAUR, CD58
6hemolytic anemia30.2CD55, CD59, HP, PIGA
7myocardial infarction30.1CD55, CD59, CD14
8systemic lupus erythematosus30.1CD55, CD59, FCGR3B
9chronic lymphocytic leukemia30.1CD55, CD59, CD58
10nephritis30.0CD55, FCGR3B
11autoimmune hemolytic anemia30.0PIGA, HP, CD59, CD55
12ischemia29.9HP, CD14, CD59, CD55
13acute leukemia29.7CD14, CD58, PLAUR
14leukemia29.0PIGA, FCGR3B, HP, PLAUR, CD58, CD14
15paroxysmal cold hemoglobinuria10.8
16budd-chiari syndrome10.5
17hemoglobinemia10.5
18paroxysmal nocturnal hemoglobinuria, somatic10.4
19cerebritis10.4
20thrombocytopenia10.4
21membranous glomerulonephritis, antenatal10.3HP, CD59
22purpura10.3
23plasmodium falciparum malaria10.3CD55, HP
24hepatitis10.2
25heparin-induced thrombocytopenia10.2
26lymphopenia10.2CD55, CD59
27uveal melanoma10.2CD59, CD55
28pulmonary tuberculosis10.2CD14, HP
29follicular lymphoma10.2CD55, CD59
30gastritis10.2CD55, CD59
31liver disease10.2HP
32iga glomerulonephritis10.1CD55, CD14
33peritonitis10.1FCGR3B, CD14
34paroxysmal nocturnal hemoglobinuria 210.1
35hematopoietic stem cell transplantation10.1
36myelofibrosis10.1
37neutropenia10.1
38hemosiderosis10.1
39blackwater fever10.1
40retinitis10.1
41nephrotic syndrome10.1CD14, HP
42vasculitis10.1FCGR3B, CD14
43hepatocellular carcinoma10.0
44multiple myeloma10.0
45antiphospholipid syndrome10.0
46fanconi syndrome10.0
47splenic infarction10.0
48hepatic vein thrombosis10.0
49patent foramen ovale10.0
50cholangitis10.0

Graphical network of the top 20 diseases related to Hemoglobinuria:



Diseases related to hemoglobinuria

Symptoms for Hemoglobinuria

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Drugs & Therapeutics for Hemoglobinuria

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Drug clinical trials:

Search ClinicalTrials for Hemoglobinuria

Search NIH Clinical Center for Hemoglobinuria

Genetic Tests for Hemoglobinuria

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Anatomical Context for Hemoglobinuria

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MalaCards organs/tissues related to Hemoglobinuria:

31
Bone, Bone marrow, Kidney, T cells, Testes, Neutrophil, Liver, Monocytes, Nk cells, Heart, Endothelial, Whole blood, Spleen, Smooth muscle, Myeloid, B cells

Animal Models for Hemoglobinuria or affiliated genes

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MGI Mouse Phenotypes related to Hemoglobinuria:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.4CD55, CD59, PLAUR, HP
2MP:00053977.2CD55, PIGA, HP, PLAUR, CD14, CD59

Publications for Hemoglobinuria

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Articles related to Hemoglobinuria:

(show top 50)    (show all 719)
idTitleAuthorsYear
1
Effective eculizumab therapy followed by BMT in a boy with paroxysmal nocturnal hemoglobinuria. (25868955)
2015
2
New Insights in Abdominal Pain in Paroxysmal Nocturnal Hemoglobinuria (PNH): A MRI Study. (25897796)
2015
3
Management of pregnancy in paroxysmal nocturnal hemoglobinuria on long-term eculizumab. (25688464)
2015
4
Eculizumab effect on the hemostatic state in patients with paroxysmal nocturnal hemoglobinuria. (25497169)
2015
5
Two case studies and a review of paroxysmal cold hemoglobinuria. (25051079)
2014
6
Paroxysmal nocturnal hemoglobinuria. (25237200)
2014
7
A Systemic Lupus Erythematosus Patient with Isolated Neutropenia and Diminished Expression of CD55 and CD59 Similar to Paroxysmal Nocturnal Hemoglobinuria. (25330534)
2014
8
Paroxysmal nocturnal hemoglobinuria: a red clot syndrome. (24200143)
2014
9
Laboratory tests for paroxysmal nocturnal hemoglobinuria (PNH). (24127129)
2013
10
Paroxysmal nocturnal hemoglobinuria and the complement system: recent insights and novel anticomplement strategies. (22990701)
2013
11
Long-term remission of paroxysmal nocturnal hemoglobinuria following chemoimmunotherapy for non-Hodgkin lymphoma. (22402359)
2012
12
A case report of concomitant paroxysmal nocturnal hemoglobinuria and heterozygous I^-thalassemia. (20556389)
2011
13
Safety and efficacy of the terminal complement inhibitor eculizumab in Japanese patients with paroxysmal nocturnal hemoglobinuria: the AEGIS clinical trial. (21222185)
2011
14
Managing a pregnant patient with paroxysmal nocturnal hemoglobinuria in the era of eculizumab. (19954846)
2010
15
The management of paroxysmal nocturnal hemoglobinuria: recent advances in diagnosis and treatment and new hope for patients. (19171207)
2009
16
Eculizumab opens a new era of treatment for paroxysmal nocturnal hemoglobinuria. (21082989)
2009
17
A case of paroxysmal nocturnal hemoglobinuria presenting with intra-abdominal bleeding due to splenic rupture, developing renal infarct. (18479304)
2008
18
The role of flow cytometry in the diagnosis of paroxysmal nocturnal hemoglobinuria in the clinical laboratory. (17658408)
2007
19
Recent advances in biological and clinical aspects of paroxysmal nocturnal hemoglobinuria. (16926130)
2006
20
Accelerated telomere shortening in glycosylphosphatidylinositol (GPI)-negative compared with GPI-positive granulocytes from patients with paroxysmal nocturnal hemoglobinuria (PNH) detected by proaerolysin flow-FISH. (15811960)
2005
21
Acute lymphoblastic leukemic transformation in a patient with chronic idiopathic myelofibrosis and paroxysmal nocturnal hemoglobinuria: a case report and review of the literature. (15628917)
2005
22
Diazepam-binding inhibitor-related protein 1: a candidate autoantigen in acquired aplastic anemia patients harboring a minor population of paroxysmal nocturnal hemoglobinuria-type cells. (15217832)
2004
23
Paroxysmal nocturnal hemoglobinuria in pregnancy. (14616248)
2003
24
Laboratory diagnosis of paroxysmal nocturnal hemoglobinuria. (14584753)
2003
25
Images in cardiovascular medicine. Recurrent myocardial infarction in a patient with paroxysmal nocturnal hemoglobinuria. (14517154)
2003
26
Polyclonal hematopoiesis maintained in patients with bone marrow failure harboring a minor population of paroxysmal nocturnal hemoglobinuria-type cells. (12676778)
2003
27
Paroxysmal nocturnal hemoglobinuria with no evidence of hemolysis presenting as Budd-Chiari syndrome. (11215746)
2000
28
Aplastic anemia and paroxysmal nocturnal hemoglobinuria: a follow-up study of the glycosylphosphatidylinositol-anchored proteins defect. (11920198)
2000
29
Acute onset hemoglobinemia and/or hemoglobinuria and sequelae following Rh(o)(D) immune globulin intravenous administration in immune thrombocytopenic purpura patients. (10753830)
2000
30
Analysis of T cells in paroxysmal nocturnal hemoglobinuria provides direct evidence that thymic T-cell production declines with age. (10515882)
1999
31
A case of pulmonary embolism caused by paroxysmal nocturnal hemoglobinuria. (9559419)
1998
32
Paroxysmal nocturnal hemoglobinuria and renal failure. (18408291)
1998
33
Delayed hemolytic transfusion reaction and paroxysmal cold hemoglobinuria: an unusual association. (15387783)
1997
34
Resistance to apoptosis caused by PIG-A gene mutations in paroxysmal nocturnal hemoglobinuria. (9238050)
1997
35
Mechanism of intravascular hemolysis in paroxysmal nocturnal hemoglobinuria (PNH). (8813092)
1996
36
Natural history of paroxysmal nocturnal hemoglobinuria. (7566002)
1995
37
High-dose recombinant human erythropoietin and low-dose corticosteroids for treatment of anemia in paroxysmal nocturnal hemoglobinuria. (8023644)
1994
38
Expression of GPI-anchor proteins during the differentiation from hematopoietic progenitors in patients with paroxysmal nocturnal hemoglobinuria]. (8028180)
1994
39
Abnormalities of PIG-A transcripts in granulocytes from patients with paroxysmal nocturnal hemoglobinuria. (8272086)
1994
40
Paroxysmal nocturnal hemoglobinuria associated with venous thrombosis and papillary endothelial hyperplasia presenting as ulcerated duodenal mass. (8060237)
1994
41
Paroxysmal nocturnal hemoglobinuria. Diagnosis aided by a monoclonal antibody directed against the decay accelerating factor glycoprotein]. (7685522)
1993
42
Deficiency of phosphatidylinositol-linked membrane proteins on erythrocytes of different subpopulations in paroxysmal nocturnal hemoglobinuria. (7691484)
1993
43
The receptor for urokinase-type plasminogen activator is deficient on peripheral blood leukocytes in patients with paroxysmal nocturnal hemoglobinuria. (1312369)
1992
44
Myeloblastic leukemoid reaction in paroxysmal nocturnal hemoglobinuria associated with myelodysplasia. (1585775)
1992
45
Two cases of paroxysmal cold hemoglobinuria with a Donath-Landsteiner antibody reactive by the indirect antiglobulin test using anti-IgG. (1996489)
1991
46
Deficiency of glycosyl-phosphatidylinositol-linked membrane glycoproteins of leukocytes in paroxysmal nocturnal hemoglobinuria, description of a new diagnostic cytofluorometric assay. (2145990)
1990
47
Paroxysmal nocturnal hemoglobinuria: termination in acute monocytic leukemia and reappearance after chemotherapy with N4-palmitoyl-1-beta-D-arabinofuranosylcytosine (PL-AC) and vincristine. (3475490)
1987
48
Erythrophagocytosis by segmented neutrophils in paroxysmal cold hemoglobinuria. (6731359)
1984
49
Paroxysmal cold hemoglobinuria with positive treponema immobilization test, report of case. (13471657)
1957
50
Paroxysmal cold hemoglobinuria; report of two cases. (18858906)
1948

Variations for Hemoglobinuria

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Expression for genes affiliated with Hemoglobinuria

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Search GEO for disease gene expression data for Hemoglobinuria.

Pathways for genes affiliated with Hemoglobinuria

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Pathways related to Hemoglobinuria according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Immune response Alternative complement pathway59
Immune response Lectin Induced complement pathway59
Immune response Classic complement pathway59
9.6CD55, CD59
2
Show member pathways
9.3PIGA, PLAUR
39.3PLAUR, HP
49.1CD55, CD59, CD14
5
Show member pathways
Complement Activation, Classical Pathway36
Complement and Coagulation Cascades36
8.8CD55, CD59, PLAUR

Compounds for genes affiliated with Hemoglobinuria

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Compounds related to Hemoglobinuria according to GeneCards Suite gene sharing:

(show top 50)    (show all 56)
idCompoundScoreTop Affiliating Genes
1alemtuzumab44 1110.9FCGR3B, PIGA
2tuberculin449.9HP, CD14
3alefacept44 1110.7CD58, FCGR3B
4anaphylatoxin449.7HP, CD59, CD55
5methylcellulose449.6CD14, CD59, PIGA
6sialic acid449.6HP, CD59, CD55
7fitc449.5CD55, CD14, CD59
8fluorochrome449.4CD14, PLAUR
9polyacrylamide449.4CD14, CD55, HP
10phospholipid449.4HP, CD55, CD59
11hirudin449.3PLAUR, CD55
12pentoxifylline44 1110.3HP, CD14
13kininogen449.3HP, PLAUR
14cytochalasin b449.2PLAUR, FCGR3B
15n-acetylglucosamine449.2PLAUR, CD14, PIGA
16aspirin44 50 28 2412.2CD59, HP, PLAUR
17neopterin449.2PLAUR, CD14, HP
18rituximab44 50 1111.2CD59, HP, FCGR3B, CD55
19p002449.1HP, PLAUR, CD14
20cyclosporin a44 28 6011.1CD55, CD14, HP, CD59
21endotoxin449.1PLAUR, HP, CD14
22n-formylmethionyl-leucylphenylalanine449.1CD55, PLAUR, FCGR3B
23lactate449.1CD14, HP, CD59
24hyaluronic acid44 2410.0HP, PLAUR, CD58
25polysaccharide449.0CD14, CD55, FCGR3B, HP
26vitamin d449.0PLAUR, HP, CD14
27fibrinogen449.0CD14, PLAUR, HP
28atp44 2810.0CD14, HP, CD55, CD59
29butyrate448.9PLAUR, CD14, CD55
30actinomycin d448.9PLAUR, CD55, HP
31iron44 249.8CD55, HP, PLAUR, CD59
32pge2448.8HP, PLAUR, CD14
33glycolipid448.7CD55, CD59, CD14, PLAUR
34creatinine448.7CD14, HP, PLAUR, CD55
35heparin44 28 24 1111.7CD55, CD14, PLAUR, HP
36vegf448.6CD14, CD55, HP, PLAUR
37superoxide44 249.6CD14, PLAUR, FCGR3B, CD59
38alanine448.6CD55, CD14, PLAUR, HP
39carbohydrates448.6PLAUR, HP, CD58, CD14
40cysteine448.5CD14, CD55, HP, PLAUR
41sucrose44 24 1110.3CD55, CD59, HP, CD14, PLAUR
42cholesterol44 28 24 1111.3CD59, PLAUR, HP, CD55, CD14
43glucose448.3CD55, CD59, CD14, PLAUR, HP
44tyrosine448.2PLAUR, HP, FCGR3B, CD59, CD55
45fmlp448.2CD55, FCGR3B, CD59, CD14, PLAUR
46serine448.1PLAUR, CD55, FCGR3B, HP, CD14
47dexamethasone44 50 28 1111.1CD58, CD55, CD14, HP, PLAUR
48calcium44 50 24 1110.8PLAUR, CD14, CD59, HP, CD55, FCGR3B
49phosphatidylinositol447.2PLAUR, CD58, FCGR3B, PIGA, CD14, CD59
50lipid447.2CD58, HP, FCGR3B, PLAUR, CD14, CD59

GO Terms for genes affiliated with Hemoglobinuria

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Cellular components related to Hemoglobinuria according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:00099868.4CD58, CD14, CD59, CD55
2extracellular vesicular exosomeGO:00700627.8HP, CD58, CD14, CD59, CD55
3anchored component of membraneGO:00312257.6CD55, CD14, CD58, PLAUR, FCGR3B
4extracellular regionGO:00055767.4FCGR3B, HP, PLAUR, CD14, CD59, CD55
5plasma membraneGO:00058867.1CD55, CD59, CD14, CD58, PLAUR, FCGR3B

Biological processes related to Hemoglobinuria according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1regulation of complement activationGO:00304499.5CD55, CD59
2C-terminal protein lipidationGO:00065019.0PLAUR, PIGA
3blood coagulationGO:00075968.6CD59, CD58, PLAUR

Molecular functions related to Hemoglobinuria according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00055156.9CD55, CD59, CD14, CD58, PLAUR, HP

Sources for Hemoglobinuria

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet