MCID: HMG002
MIFTS: 55

Hemoglobinuria malady

Immune diseases, Blood diseases categories

Summaries for Hemoglobinuria

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63Wikipedia, 32MalaCards
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Wikipedia:63 In medicine, hemoglobinuria or haemoglobinuria is a condition in which the oxygen transport protein... more...

MalaCards: Hemoglobinuria, also known as haemoglobinuria, is related to aplastic anemia and paroxysmal nocturnal hemoglobinuria. An important gene associated with Hemoglobinuria is PIGA (phosphatidylinositol glycan anchor biosynthesis, class A), and among its related pathways are Dissolution of Fibrin Clot and amb2 Integrin signaling. The compounds pge2 and alemtuzumab have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and kidney, and related mouse phenotypes are renal/urinary system and hematopoietic system.

Aliases & Classifications for Hemoglobinuria

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8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 39NCIt, 25ICD10
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Related Diseases for Hemoglobinuria

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17GeneCards, 18GeneDecks
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Diseases related to Hemoglobinuria via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 179)
idRelated DiseaseScoreTop Affiliating Genes
1aplastic anemia30.9CD55, CD59, PIGA
2paroxysmal nocturnal hemoglobinuria30.7HP, CD55, CD59, CD14, CD58, PIGA
3leukemia30.6CD59, CD14, CD58, PIGA, CSF3, CD55
4acute leukemia30.5CSF3, CD58, CD14, PLAUR
5thrombocytopenia30.4CSF3, PIGA, HP, RECK
6hepatitis30.2HP
7hemolytic anemia30.2G6PD, PIGA, CD59, CD55, HP
8pancytopenia30.1CSF3, CD55, HP
9blackwater fever30.1G6PD
10multiple myeloma30.0CSF3
11myeloma30.0CD14, CD58, CSF3
12ischemia30.0HP, CD55, CD59, CD14
13sickle cell disease30.0HP, G6PD
14myocardial infarction30.0RECK, CD55, CD59, CD14
15autoimmune hemolytic anemia30.0G6PD, PIGA, CD59, CD55, HP
16hepatocellular carcinoma30.0PLAUR, PLAU, RECK, CD14, CD58
17pneumonia29.9CSF3
18hepatitis c29.7CD58, HP
19myeloid leukemia29.7CSF3, CD14
20acute myocardial infarction29.7CD14
21malaria29.7ACHE, RECK, HP, G6PD
22deficiency anemia29.7CSF3, G6PD, PIGA, CD59, CD55, HP
23systemic lupus erythematosus29.7KLRC2, CD59, CD55, RECK, FCGR3B
24non-hodgkin lymphoma29.7CD55, CD59, CD14, CSF3
25paroxysmal cold hemoglobinuria10.3
26cerebritis10.3
27paroxysmal nocturnal hemoglobinuria, somatic10.3
28purpura10.2
29retinitis10.1
30stroke, ischemic10.1
31hemosiderosis10.1
32splenic infarction10.1
33hepatic vein thrombosis10.1
34complement deficiency10.1
35myelofibrosis10.1
36eclampsia10.1
37pre-eclampsia10.1
38antiphospholipid syndrome10.0
39patent foramen ovale10.0
40fanconi syndrome10.0
41hepatitis a10.0
42cholangitis10.0
43chronic lymphocytic leukemia10.0
44lymphoblastic leukemia10.0
45papilledema10.0
46syphilis10.0
47thymoma10.0
48paroxysmal nocturnal hemoglobinuria 210.0
49peritonitis10.0FCGR3B, CD14
50hepatitis b10.0PLAUR, CD58

Graphical network of the top 20 diseases related to Hemoglobinuria:



Diseases related to hemoglobinuria

Clinical Features for Hemoglobinuria

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Drugs & Therapeutics for Hemoglobinuria

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Hemoglobinuria

Drug clinical trials:

Search ClinicalTrials for Hemoglobinuria

Search NIH Clinical Center for Hemoglobinuria

Search CenterWatch for Hemoglobinuria

Genetic Tests for Hemoglobinuria

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Anatomical Context for Hemoglobinuria

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32MalaCards
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MalaCards organs/tissues related to Hemoglobinuria:

32
Bone, Bone marrow, Kidney, T cells, Testes, Liver, Monocytes, Endothelial, Heart, Smooth muscle, Myeloid, Spleen, Nk cells, Whole blood, B cells, Lung

Animal Models for Hemoglobinuria or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Hemoglobinuria:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536710.1CD59, CD55, HP, PLAUR, GFRA1, CSF3
2MP:00053979.8ACHE, CSF3, G6PD, PIGA, CD59, CD55
3MP:00107689.6G6PD, PIGA, CD14, CD59, CD55, HP

Publications for Hemoglobinuria

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50PubMed
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Articles related to Hemoglobinuria:

(show top 50)    (show all 688)
idTitleAuthorsYear
1
Long-term remission of paroxysmal nocturnal hemoglobinuria following chemoimmunotherapy for non-Hodgkin lymphoma. (22402359)
2012
2
Association analysis of cytokine polymorphisms and plasma level in Northern Chinese Han patients with paroxysmal nocturnal hemoglobinuria. (22800824)
2012
3
Gross hemoglobinuria and oliguria are common transient complications of sclerotherapy for venous malformations: review of 475 procedures. (22915413)
2012
4
Clinical features and prognostic factors of Asian patients with paroxysmal nocturnal hemoglobinuria: results from a single center in China. (22281992)
2012
5
Detection of paroxysmal nocturnal hemoglobinuria-phenotype in patients with chronic lymphocytic leukemia and multiple myeloma. (22771645)
2012
6
Successful cholecystectomy in a patient with aplastic anemia-paroxysmal nocturnal hemoglobinuria during eculizumab treatment. (22739575)
2012
7
Thrombosis in paroxysmal noctural hemoglobinuria: an indication for eculizumab? (22262634)
2012
8
Percussion hemoglobinuria - a novel term for hand trauma-induced mechanical hemolysis: a case report. (21982397)
2011
9
Paroxysmal nocturnal hemoglobinuria (PNH): higher sensitivity and validity in diagnosis and serial monitoring by flow cytometric analysis of reticulocytes. (21359652)
2011
10
Monoclonal antibodies in rare acquired thrombotic disorders: the paradigms of paroxysmal nocturnal hemoglobinuria, thrombotic thrombocytopenic purpura and central retinal vein occlusion. (19538160)
2010
11
Long-term effect of the complement inhibitor eculizumab on kidney function in patients with paroxysmal nocturnal hemoglobinuria. (20658586)
2010
12
Paroxysmal nocturnal hemoglobinuria and myelodysplastic syndromes: clonal expansion of PIG-A-mutant hematopoietic cells in bone marrow failure. (19118373)
2009
13
Paroxysmal nocturnal hemoglobinuria (PNH) and pregnancy in the era of eculizumab. (18952283)
2009
14
Liver transplant for Budd-Chiari syndrome caused by paroxysmal nocturnal hemoglobinuria. (18954293)
2008
15
Use of splenic artery embolization to relieve tense ascites following liver transplantation in a patient with paroxysmal nocturnal hemoglobinuria. (17969202)
2007
16
Haptoglobin therapy during pregnancy for paroxysmal nocturnal hemoglobinuria with renal failure. (17459392)
2007
17
The pathophysiology of paroxysmal nocturnal hemoglobinuria. (17379062)
2007
18
Eculizumab in paroxysmal nocturnal hemoglobinuria. (17192547)
2006
19
Catheter-directed thrombolysis and thrombectomy for the Budd-Chiari syndrome in paroxysmal nocturnal hemoglobinuria in three patients. (16517788)
2006
20
Off-pump coronary artery bypass grafting in a patient with paroxysmal nocturnal hemoglobinuria. (15552971)
2004
21
Laboratory diagnosis of paroxysmal nocturnal hemoglobinuria. (14584753)
2003
22
Cardiac surgery in a patient with paroxysmal nocturnal hemoglobinuria. (12161376)
2002
23
Activated platelets of patients with paroxysmal nocturnal hemoglobinuria express cellular prion protein. (12070046)
2002
24
Diagnostic significance of measurement of the receptor for urokinase-type plasminogen activator on granulocytes and in plasma from patients with paroxysmal nocturnal hemoglobinuria. (12041678)
2002
25
Investigation on apoptosis in paroxysmal nocturnal hemoglobinuria (PNH) granulocytes]. (11769477)
2001
26
Acute onset hemoglobinemia and/or hemoglobinuria and sequelae following Rh(o)(D) immune globulin intravenous administration in immune thrombocytopenic purpura patients. (10753830)
2000
27
In vitro proliferation and differentiation of megakaryocytic progenitors in patients with aplastic anemia, paroxysmal nocturnal hemoglobinuria, and the myelodysplastic syndromes. (11072031)
2000
28
Allogeneic bone marrow transplantation for paroxysmal nocturnal hemoglobinuria. (10627666)
2000
29
Research directions in paroxysmal nocturnal hemoglobinuria. (10203713)
1999
30
Effective treatment combining antithymocyte globulin, cyclosporin A, and granulocyte colony-stimulating factor for atypical paroxysmal nocturnal hemoglobinuria accompanied by bone marrow hypoplasia]. (10222633)
1999
31
Somatic mutation and clonal selection in the pathogenesis and in the control of paroxysmal nocturnal hemoglobinuria. (9565157)
1998
32
New somatic mutation in the PIG-A gene emerges at relapse of paroxysmal nocturnal hemoglobinuria. (9787183)
1998
33
Resistance to apoptosis caused by PIG-A gene mutations in paroxysmal nocturnal hemoglobinuria. (9238050)
1997
34
Sequential development of myelodysplasia and paroxysmal nocturnal hemoglobinuria in a patient with preceding aplastic anemia. (9071825)
1997
35
Structural and functional analysis of the Pig-a protein that is mutated in paroxysmal nocturnal hemoglobinuria. (9398536)
1997
36
Molecular basis of the heterogeneity of expression of glycosyl phosphatidylinositol anchored proteins in paroxysmal nocturnal hemoglobinuria. (8630422)
1996
37
Thrombotic complication in the course of aplastic anemia-paroxysmal nocturnal hemoglobinuria syndrome; possible involvement of dysplasminogenemia (plasminogen Tochigi) in the pathogenesis of thrombosis]. (8727351)
1996
38
Bilateral papilledema with retinal hemorrhages in association with cerebral venous sinus thrombosis and paroxysmal nocturnal hemoglobinuria. (8862066)
1996
39
Immunophenotypic analysis of reticulocytes in paroxysmal nocturnal hemoglobinuria. (7543308)
1995
40
An etiologic study of hemoglobinuria and blackwater fever in the Kivu Mountains, Zaire. (7794063)
1995
41
The PIG-A gene somatic mutation responsible for paroxysmal nocturnal hemoglobinuria. (8647522)
1995
42
Characterization of genomic PIG-A gene: a gene for glycosylphosphatidylinositol-anchor biosynthesis and paroxysmal nocturnal hemoglobinuria. (8193350)
1994
43
A deficiency in CDw52 (CAMPATH-1 antigen) of paroxysmal nocturnal hemoglobinuria lymphocytes. (8260716)
1993
44
Paroxysmal nocturnal hemoglobinuria due to hereditary nucleotide deletion in the HRF20 (CD59) gene. (1382994)
1992
45
Two cases of paroxysmal cold hemoglobinuria with a Donath-Landsteiner antibody reactive by the indirect antiglobulin test using anti-IgG. (1996489)
1991
46
Erythrocyte vesiculation in paroxysmal nocturnal hemoglobinuria. (1725134)
1991
47
Paroxysmal cold hemoglobinuria. Transmission and scanning electron microscopy features of erythrocytes. (1146755)
1975
48
Foreword and a proposal for considering paroxysmal nocturnal hemoglobinuria (PNH) as a "candidate" myeloproliferative disorder. (5767060)
1969
49
THE SPECIFICITY OF THE ANTIBODY IN PAROXYSMAL COLD HEMOGLOBINURIA (P.C.H.). (14048066)
1963
50
Hemoglobinemia and the hemoglobinurias. (21003944)
1945

Genetic Variations for Hemoglobinuria

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Expression for genes affiliated with Hemoglobinuria

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hemoglobinuria

Search GEO for disease gene expression data for Hemoglobinuria.

Pathways for genes affiliated with Hemoglobinuria

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53Reactome, 37NCBI BioSystems Database, 29KEGG
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Compounds for genes affiliated with Hemoglobinuria

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44Novoseek, 11DrugBank, 49PharmGKB, 28IUPHAR, 24HMDB, 59Tocris Bioscience
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Compounds related to Hemoglobinuria according to GeneCards/GeneDecks:

(show top 50)    (show all 84)
idCompoundScoreTop Affiliating Genes
1pge24410.8PLAU
2alemtuzumab44 1111.7FCGR3B, PIGA, CSF3
3methylcellulose4410.7CD14, PIGA, CSF3, CD59
4n-formylmethionyl-leucylphenylalanine4410.7CSF3, CD55, PLAUR, FCGR3B
5rituximab44 49 1112.6CD55, HP, FCGR3B, CD59, CSF3
6nitroblue tetrazolium4410.6G6PD, CSF3, CD14
7carbohydrates4410.6CD58, CD14, HP, RECK, PLAUR
8diisopropylfluorophosphate4410.6PLAU, ACHE, PLAUR
9n-acetylglucosamine4410.6PIGH, CD14, PLAUR, RECK, PIGA
10anaphylatoxin4410.6CD55, CD59, HP
11aspirin44 49 28 2413.6PLAU, HP, CD59, PLAUR, G6PD
12aprotinin44 1111.6PLAU, RECK, PLCG1, PLAUR
13endotoxin4410.6CSF3, CD14, HP, RECK, PLAUR
14sucrose44 11 2412.6CD55, HP, CD14, CD59, RECK, PLAUR
15gp 1304410.6RECK, CSF3, HP, PLAUR
16dexamethasone44 49 28 1113.6CD55, PLAUR, CD58, CD14, PLCG1
17fitc4410.6CD59, CD14, CD55
18phosphatidylserine44 28 1112.6G6PD, CD14, RECK, PLCG1, FCGR3B
19creatinine4410.6PLAUR, CD55, PLAU, CD14, HP
20dmso4410.6G6PD, PLAU, PLAUR, RECK, CSF3
21heparin44 28 11 2413.6RECK, HP, PLCG1, GFRA1, CD55, CD14
22serine4410.6PLCG1, HP, ACHE, CD55, G6PD, FCGR3B
23sphingosine44 11 2412.6PLAUR, PLAU, PIGH, PIGA
24sialic acid4410.5CD59, RECK, CD55, HP
25glycolipid4410.5CD14, CD59, CD55, RECK, PLAU, PLCG1
26fibrinogen4410.5CD14, HP, RECK, PLAU, PLAUR
27polysaccharide4410.5FCGR3B, PLCG1, RECK, CD14, CD55, PLAU
28lactate4410.5HP, RECK, G6PD, CD14, CD59, PLAU
29cisplatin44 49 59 1113.5PLAUR, G6PD, CSF3, CD55, CD58, PLAU
30histamine44 28 2412.5PLCG1, PLAU, CD55, CD160, CD14
31superoxide44 2411.5CSF3, FCGR3B, CD160, G6PD, CD14, CD59
32fmlp4410.5CD14, CEACAM8, FCGR3B, CSF3, PLCG1, PLAUR
33glucose4410.4PLAUR, CD55, CD59, CD14, RECK
34cyclosporin a44 28 5912.4PLCG1, CSF3, RECK, CD160, CD14, CD59
35h2o24410.4FCGR3B, PLAU, HP, PLAUR, PLCG1, G6PD
36vegf4410.4CD14, CSF3, PLCG1, CD55, HP, RECK
37cysteine4410.4PLAUR, PLAU, PLCG1, RECK, HP, CD55
38herbimycin a44 5911.4PLAU, PLAUR, PLCG1, CD14
39doxorubicin44 49 1112.4CSF3, RECK, PLAU, G6PD, CD58
40actinomycin d4410.4G6PD, CD55, PLAUR, PLAU, HP
41hirudin4410.4PLAUR, PLAU, CD55
42hyaluronic acid44 2411.4PLAU, HP, CD58, PLAUR
43cholesterol44 28 11 2413.4RECK, CD59, PLAUR, HP, CD14, CD55
44lipid4410.3FCGR3B, G6PD, CD58, CD14, CD55, CD59
45phosphatidylinositol4410.3CD59, PLAU, PLAUR, PLCG1, GFRA1, FCGR3B
46tyrosine4410.3FCGR3B, CSF3, CD160, CD59, CD55, HP
47alpha-naphthyl butyrate4410.3CD14, CSF3
48folate4410.2RECK, PLCG1, HP, G6PD
49glutamine4410.2G6PD, PLAU, PLAUR, CD14, PLCG1
50aerolysin4410.1PIGA, PLCG1

GO Terms for genes affiliated with Hemoglobinuria

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16Gene Ontology
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Cellular components related to Hemoglobinuria according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complexGO:00050610.4PIGH, PIGA
2anchored to membraneGO:03122510.1CEACAM8, CD58, CD14, CD55, RECK, PLAUR
3cell surfaceGO:00998610.1CD14, CD59, CD55, PLAU, PLAUR, ACHE
4extracellular spaceGO:00561510.0CSF3, CD14, CD59, HP, PLAU, GFRA1
5extracellular regionGO:0055769.8CD14, CD59, CD55, HP, PLAU, PLAUR
6plasma membraneGO:0058869.7CD59, CD14, CD160, CD58, KLRC2, CD55

Biological processes related to Hemoglobinuria according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1C-terminal protein lipidationGO:00650110.4PLAUR, PIGH, PIGA
2preassembly of GPI anchor in ER membraneGO:01625410.4PIGH, PIGA
3cell surface receptor signaling pathwayGO:00716610.2GFRA1, CD59, CD14, CD160
4blood coagulationGO:00759610.1CD58, CD59, PLAU, PLAUR, PLCG1
5innate immune responseGO:0450879.9PLCG1, CD55, CD59, CD14, KLRC2

Molecular functions related to Hemoglobinuria according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phosphatidylinositol N-acetylglucosaminyltransferase activityGO:01717610.1PIGH, PIGA
2protein bindingGO:0055159.8G6PD, PIGA, CD58, CD14, CD59, HP

Products for genes affiliated with Hemoglobinuria

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Sources for Hemoglobinuria

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet