MCID: HML002
MIFTS: 62

Hemolytic Anemia

Categories: Blood diseases, Immune diseases, Rare diseases, Metabolic diseases, Genetic diseases

Aliases & Classifications for Hemolytic Anemia

MalaCards integrated aliases for Hemolytic Anemia:

Name: Hemolytic Anemia 37 12 28 14 59
Anemia, Hemolytic 41 69
Anemia Hemolytic 12 51

Classifications:



External Ids:

Disease Ontology 12 DOID:583
ICD10 32 D55-D59
MeSH 41 D000743
NCIt 46 C34376
UMLS 69 C0002878

Summaries for Hemolytic Anemia

PubMed Health : 59
About hemolytic anemia: Hemolytic anemia (HEE-moh-lit-ick uh-NEE-me-uh) is a condition in which red blood cells are destroyed and removed from the bloodstream before their normal lifespan is over.Red blood cells are disc-shaped and look like doughnuts without holes in the center. These cells carry oxygen to your body. They also remove carbon dioxide (a waste product) from your body.Red blood cells are made in the bone marrow—a sponge-like tissue inside the bones. They live for about 120 days in the bloodstream and then die.White blood cells and platelets (PLATE-lets) also are made in the bone marrow. White blood cells help fight infections. Platelets stick together to seal small cuts or breaks on blood vessel walls and stop bleeding.When blood cells die, the body's bone marrow makes more blood cells to replace them. However, in hemolytic anemia, the bone marrow can't make red blood cells fast enough to meet the body's needs.Hemolytic anemia can lead to many health problems, such as fatigue (tiredness), pain, irregular heartbeats called arrhythmias (ah-RITH-me-ahs), an enlarged heart, and heart failure.

MalaCards based summary : Hemolytic Anemia, also known as anemia, hemolytic, is related to pyruvate kinase deficiency of red cells and congenital nonspherocytic hemolytic anemia, and has symptoms including icterus An important gene associated with Hemolytic Anemia is HBB (Hemoglobin Subunit Beta), and among its related pathways/superpathways are Metabolism and Glycosaminoglycan metabolism. The drugs Nitric Oxide and Peginterferon alfa-2a have been mentioned in the context of this disorder. Affiliated tissues include heart, bone and bone marrow, and related phenotypes are Increased simian virus 40 (SV40) infection and hematopoietic system

Wikipedia : 72 Hemolytic anemia or haemolytic anaemia is a form of anemia due to hemolysis, the abnormal breakdown of... more...

Related Diseases for Hemolytic Anemia

Diseases in the Hemolytic Anemia family:

Anemia, Autoimmune Hemolytic Congenital Hemolytic Anemia
Hemolytic Anemia Due to Erythrocyte Adenosine Deaminase Overproduction

Diseases related to Hemolytic Anemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 463)
# Related Disease Score Top Affiliating Genes
1 pyruvate kinase deficiency of red cells 34.0 G6PD PKLR
2 congenital nonspherocytic hemolytic anemia 33.9 G6PD GPI NT5C3A PKLR
3 congenital hemolytic anemia 33.0 ANK1 G6PD GPI HBA2 HBB PKLR
4 glutathione peroxidase deficiency 32.8 HBA2 HBB
5 glutathione synthetase deficiency 32.3 G6PD GSS
6 hereditary spherocytosis 32.3 ANK1 EPB42 G6PD HBB PKLR RHAG
7 heinz body anemias 31.5 HBA2 HBB
8 glucosephosphate isomerase deficiency 30.7 G6PD GPI
9 hereditary elliptocytosis 30.4 ANK1 SLC4A1 SPTB
10 beta-thalassemia 29.8 G6PD HBA2 HBB SPTB
11 sickle cell disease 29.6 G6PD HBA2 HBB
12 deficiency anemia 29.6 G6PD HBA2 HBB
13 kernicterus 29.6 G6PD SLC4A1
14 alpha-thalassemia 29.6 G6PD HBA2 HBB
15 malaria 29.4 ADAMTS13 G6PD HBA2 HBB PKLR SLC4A1
16 hemolytic anemia, nonspherocytic, due to hexokinase deficiency 12.5
17 warm antibody hemolytic anemia 12.4
18 uridine 5-prime monophosphate hydrolase deficiency, hemolytic anemia due to 12.4
19 gamma-glutamylcysteine synthetase deficiency, hemolytic anemia due to 12.3
20 renal tubular acidosis, distal, with hemolytic anemia 12.3
21 adenylate kinase deficiency, hemolytic anemia due to 12.3
22 glutathione synthetase deficiency of erythrocytes, hemolytic anemia due to 12.3
23 anemia, autoimmune hemolytic 12.3
24 hemolytic anemia, nonspherocytic, due to glucose phosphate isomerase deficiency 12.3
25 hemolytic anemia, cd59-mediated, with or without immune-mediated polyneuropathy 12.3
26 systemic lupus erythematosus with hemolytic anemia 1 12.2
27 drug-induced autoimmune hemolytic anemia 12.1
28 thrombotic thrombocytopenic purpura, congenital 12.1
29 mixed-type autoimmune hemolytic anemia 12.1
30 autoimmune hemolytic anemia, warm type 12.1
31 hemolytic anemia, lethal congenital nonspherocytic, with genital and other abnormalities 12.1
32 glut1 deficiency syndrome 2 12.0
33 adenosine deaminase, elevated, hemolytic anemia due to 12.0
34 hemolytic anemia with thermal sensitivity of red cells 12.0
35 hemolytic anemia due to glutathione reductase deficiency 12.0
36 triosephosphate isomerase deficiency 12.0
37 lymphopenic hypergammaglobulinemia, antibody deficiency, autoimmune hemolytic anemia, and glomerulonephritis 11.9
38 hemolytic anemia due to glyceraldehyde-3-phosphate dehydrogenase deficiency 11.9
39 neonatal autoimmune hemolytic anemia 11.9
40 autoimmune hemolytic anemia-autoimmune thrombocytopenia-primary immunodeficiency syndrome 11.9
41 hemolytic anemia due to erythrocyte adenosine deaminase overproduction 11.9
42 anemia, nonspherocytic hemolytic, due to g6pd deficiency 11.9
43 glucosephosphate dehydrogenase deficiency 11.8
44 evans' syndrome 11.8
45 glucose phosphate isomerase deficiency 11.8
46 paroxysmal cold hemoglobinuria 11.8
47 cold agglutinin disease 11.8
48 hemolytic-uremic syndrome 11.7
49 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 11.7
50 rh-null, regulator type 11.6

Graphical network of the top 20 diseases related to Hemolytic Anemia:



Diseases related to Hemolytic Anemia

Symptoms & Phenotypes for Hemolytic Anemia

UMLS symptoms related to Hemolytic Anemia:


icterus

GenomeRNAi Phenotypes related to Hemolytic Anemia according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased simian virus 40 (SV40) infection GR00356-A-2 8.8 HK1 PGK1 PKLR

MGI Mouse Phenotypes related to Hemolytic Anemia:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.93 PIGA PKLR RHAG SLC4A1 SPTB ADAMTS13
2 homeostasis/metabolism MP:0005376 9.77 ADAMTS13 AK1 ANK1 CD59 EPB42 G6PD
3 mortality/aging MP:0010768 9.4 SPTB ADAMTS13 ANK1 CD59 G6PD GCLC

Drugs & Therapeutics for Hemolytic Anemia

PubMedHealth treatment related to Hemolytic Anemia: 59

Treatments for hemolytic anemia include blood transfusions, medicines, plasmapheresis (PLAZ-meh-feh-RE-sis), surgery, blood and marrow stem cell transplants, and lifestyle changes.People who have mild hemolytic anemia may not need treatment, as long as the condition doesn't worsen. People who have severe hemolytic anemia usually need ongoing treatment. Severe hemolytic anemia can be fatal if it's not properly treated.

Drugs for Hemolytic Anemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 171)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nitric Oxide Approved Phase 4 10102-43-9 145068
2
Peginterferon alfa-2a Approved, Investigational Phase 4,Phase 2 198153-51-4 5360545
3
Ribavirin Approved Phase 4,Phase 3,Phase 2 36791-04-5 37542
4
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
5
Mannitol Approved, Investigational Phase 4 69-65-8 6251 453
6
Prilocaine Approved Phase 4 721-50-6 4906
7 Racepinephrine Approved Phase 4 329-65-7
8
Iron Approved Phase 4,Phase 2 7439-89-6 23925
9
Metformin Approved Phase 4 657-24-9 4091 14219
10
Desogestrel Approved Phase 4 54024-22-5 40973
11
Etonogestrel Approved, Investigational Phase 4 54048-10-1 6917715 40976
12 Antioxidants Phase 4,Phase 2
13
Bilirubin Phase 4 635-65-4 5280352
14 Pharmaceutical Solutions Phase 4,Phase 1
15 Protective Agents Phase 4,Phase 3,Phase 2
16 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
17 Antimetabolites Phase 4,Phase 3,Phase 2
18 Hormone Antagonists Phase 4,Phase 3,Phase 2
19 Hormones Phase 4,Phase 3,Phase 2
20 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2
21 Antiviral Agents Phase 4,Phase 3,Phase 2,Phase 1
22 Interferon-alpha Phase 4,Phase 3,Phase 2
23 interferons Phase 4,Phase 3,Phase 2
24 diuretics Phase 4
25 Epinephryl borate Phase 4
26 Natriuretic Agents Phase 4
27 Liver Extracts Phase 4,Phase 3,Phase 2
28 Iron Chelating Agents Phase 4,Phase 2
29 Hypoglycemic Agents Phase 4
30 Contraceptive Agents Phase 4
31 Contraceptives, Oral Phase 4
32
Ethylene Phase 4 74-85-1 6325
33 Progestins Phase 4
34
Methylprednisolone Approved, Vet_approved Phase 3,Phase 2 83-43-2 6741
35
Prednisolone Approved, Vet_approved Phase 3,Phase 2 50-24-8 5755
36
Cyclophosphamide Approved, Investigational Phase 3,Phase 2,Phase 1 50-18-0, 6055-19-2 2907
37
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 22916-47-8 4189
38
rituximab Approved Phase 3,Phase 2 174722-31-7 10201696
39
Primaquine Approved Phase 3 90-34-6 4908
40
Fludarabine Approved Phase 3,Phase 2 21679-14-1, 75607-67-9 30751
41
Vidarabine Approved, Investigational Phase 3,Phase 2 24356-66-9 21704 32326
42
Artemether Approved Phase 3 71963-77-4 68911 119380
43
Dapsone Approved, Investigational Phase 3 80-08-0 2955
44
Lumefantrine Approved Phase 3 82186-77-4 6437380
45
Proguanil Approved Phase 3 500-92-5 4923
46
chloroquine Approved, Investigational, Vet_approved Phase 3 54-05-7 2719
47
Chlorambucil Approved Phase 3 305-03-3 2708
48
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
49
leucovorin Approved, Nutraceutical Phase 3 58-05-9 143 6006
50 Orange Approved, Nutraceutical Phase 3

Interventional clinical trials:

(show top 50) (show all 78)

# Name Status NCT ID Phase Drugs
1 Efficacy of Yinzhihuang Oral Liquid on Indirect Bilirubin of Neonates With Glucose-6-phosphate Dehydrogenase Deficiency Unknown status NCT02594904 Phase 4 Yinzhihuang Oral Liquid
2 Retreatment of Dialysis Patients With Chronic Hepatitis C With Pegylated Interferon Alfa-2a Plus Low Dose Ribavirin Completed NCT00491179 Phase 4 Pegylated interferon alfa-2a and ribavirin;Pegylated interferon alfa-2a and ribavirin
3 Pegylated Interferon Alfa-2a Plus Low Dose Ribavirin for Treatment-Naïve Hemodialysis Patients With Chronic Hepatitis C Completed NCT00491244 Phase 4 Peginterferon alfa-2a and ribavirin;Peginterferon alfa-2a
4 Evaluation of Ureteral Patency in the Post-indigo Carmine Era Completed NCT02677623 Phase 4 Pyridium;Sodium Fluorescein;Mannitol
5 Low-Dose Peginterferon and Ribavirin to Treat Chronic Hepatitis C in Patients Infected With HCV Genotype 2 or 3 Completed NCT00056862 Phase 4 Peginterferon alfa-2a;Peginterferon alfa-2a;Ribavirin
6 Pegylated Interferon and Ribavirin to Treat Chronic Hepatitis C With and Without Kidney Disease Completed NCT00028093 Phase 4 Peginterferon alfa-2a with Ribavirin;Peginterferon alfa-2a
7 Long-Term Therapy With Ribavirin for Chronic Hepatitis C Completed NCT00001854 Phase 4 Ribavirin
8 The Potential Hepatoprotective Effect of Metformin in Patients With Beta Thalassemia Major Recruiting NCT02984475 Phase 4 Metformin
9 Contraception in Women With Sickle Cell Disease Active, not recruiting NCT02594462 Phase 4 etonogestrel-releasing implant contraceptive
10 Rituximab in Auto-Immune Hemolytic Anemia Completed NCT01181154 Phase 3 rituximab (Mabthera®);Placebo
11 Prednisolone +/- Addition of Anti-CD20 Antibody, Rituximab, in Patients With Immune Hemolytic Anemia Completed NCT01134432 Phase 3 prednisolone + mabthera;Prednisolone
12 Combination Drug Therapy for Patients With Hepatitis C Completed NCT00001729 Phase 3 Ribavirin
13 Eight Week Primaquine Regimen for the Treatment of Vivax Malaria Completed NCT00158587 Phase 3 primaquine
14 Doppler or Amniocentesis to Predict Fetal Anemia Completed NCT00295516 Phase 3
15 Ofatumumab Added to Fludarabine-Cyclophosphamide vs Fludarabine-Cyclophosphamide Combination in Relapsed Subjects With Chronic Lymphocytic Leukemia Completed NCT00824265 Phase 3 OFC Infusion;FC infusion
16 Lapdap and Coartemether for Uncomplicated Malaria Completed NCT00118794 Phase 3 Chlorproguanil-dapsone (Lapdap);Lumefantrine-artemether (Coartemether )
17 Study to Assess the Incidence of Hemolysis, Safety, and Efficacy of Tafenoquine (SB-252263, WR238605) Versus Primaquine in Subjects With Plasmodium Vivax Malaria Completed NCT02216123 Phase 3 Tafenoquine;Tafenoquine Placebo;Chloroquine;Primaquine;Primaquine Placebo
18 Ofatumumab Maintenance Treatment vs No Further Treatment in Relapsed CLL Responding to Induction Therapy Active, not recruiting NCT01039376 Phase 3
19 Ofatumumab + Chlorambucil vs Chlorambucil Monotherapy in Previously Untreated Patients With Chronic Lymphocytic Leukemia Active, not recruiting NCT00748189 Phase 3 chlorambucil, tablets;ofatumumab (GSK1841157) infusion
20 A Phase 3, Randomized, Controlled Study of Prophylactic and On-demand Treatment of cTTP With BAX 930 (rADAMTS13) Active, not recruiting NCT03393975 Phase 3
21 Efficacy and Safety of Levamisole Combined With Standard Prednisolone in Warm Antibody Autoimmune Hemolytic Anemia. Unknown status NCT01579110 Phase 2 levamisole;Prednisone
22 Safety and Efficacy of Levamisole Combined With Cyclosporine A in Patients With Classic Paroxysmal Nocturnal Hemoglobinuria Unknown status NCT01642979 Phase 2 Levamisole+cyclosporin A+Glucocorticoids;cyclosporin A+Glucocorticoids;Glucocorticoids
23 Safety and Efficacy of Levamisole Combined With Cyclosporine A in Patients With Subclinical Paroxysmal Nocturnal Hemoglobinuria and PNH in the Setting of Another Bone Marrow Failure Syndromes(PNH-2013) Unknown status NCT01760096 Phase 2 Levamisole+cyclosporin A+Glucocorticoids;cyclosporin A+Glucocorticoids;Glucocorticoids
24 A Randomized Trial of LOVAZA in Pediatric Sickle Cell Disease (SCD) Unknown status NCT01202812 Phase 2
25 A Single-Arm Pilot Study With Low-Dose Rituximab Plus Standard Oral Prednisone In Idiopathic Autoimmune Hemolytic Anemia Completed NCT01345708 Phase 2 prednisone, low dose rituximab
26 Combination Chemotherapy and Rituximab in Treating Patients With Chronic Lymphocytic Leukemia (CLL) That Did Not Respond to Fludarabine, CLL With Autoimmune Haemolytic Anemia (AIHA) or Richter's Transformation (RT) Completed NCT00309881 Phase 2 cyclophosphamide;doxorubicin hydrochloride;prednisone;vincristine sulfate
27 High Dose Ribavirin in the Treatment of Chronic Hepatitis C Completed NCT00944684 Phase 2 High ribavirin dose;Standard ribavirin dose
28 Bendamustine and Rituximab Combination Therapy for Cold Agglutinin Disease Completed NCT02689986 Phase 2 Bendamustine, Rituximab
29 Study of Deferasirox Relative to Subcutaneous Deferoxamine in Sickle Cell Disease Patients Completed NCT00110617 Phase 2 Deferasirox (ICL670);Deferoxamine (DFO)
30 Clinical Trial to Study the Safety and Tolerability of Memantin Mepha® in Sickle Cell Disease Patients Completed NCT02615847 Phase 2 Memantinhydrochlorid
31 Therapy for Chronic Cold Agglutinin Disease Completed NCT00373594 Phase 2 Rituximab;Fludarabine
32 Vitamin E Supplement in Patients With Cirrhosis and Acanthocytosis Completed NCT01463735 Phase 2
33 Unrelated Hematopoietic Stem Cell Transplantation(HSCT) for Genetic Diseases of Blood Cells Completed NCT00730314 Phase 1, Phase 2
34 Glutamine Therapy for Hemolysis-Associated Pulmonary Hypertension Completed NCT01048905 Phase 2 L-Glutamine;L-Glutamine
35 Rituximab in Adult Acquired Idiopathic Thrombotic Thrombocytopenic Purpura Completed NCT00907751 Phase 2 rituximab
36 Phase II Study of High-Dose Cyclophosphamide in Patients With Severe Autoimmune Hematologic Disease Completed NCT00010387 Phase 2 cyclophosphamide;filgrastim
37 Ofatumumab Plus Bendamustine in Frontline and Relapsed Chronic Lymphocytic Leukaemia (CLL) Completed NCT01520922 Phase 2 Bendamustine
38 Efficacy of PegInterferon-Ribavirin-Boceprevir Therapy in Patients Infected With G1 HCV With Cirrhosis, Awaiting Liver Transplantation Completed NCT01463956 Phase 2 Boceprevir;Ribavirin
39 A Safety and Efficacy Study of R935788 in the Treatment of Warm Antibody Autoimmune Hemolytic Anemia (AIHA) Recruiting NCT02612558 Phase 2 Fostamatinib 150 mg bid
40 Evaluating the Interest of Interleukine-2 for Patients With Active Warm Hemolytic Anemia Resistant to Conventional Treatment Recruiting NCT02389231 Phase 1, Phase 2 Interleukine-2
41 Study to Assess the Safety, Tolerability, Efficacy and PK of APL-2 in Patients With wAIHA or CAD Recruiting NCT03226678 Phase 2 APL-2
42 Improving the Results of Bone Marrow Transplantation for Patients With Severe Congenital Anemias Recruiting NCT00061568 Phase 2 Alemtuzumab (Campath );Sirolimus (Rapamune )
43 Feasibility Study of Unfractionated Heparin in Acute Chest Syndrome Recruiting NCT02098993 Phase 2 Unfractionated heparin
44 A Study of AG-348 in Adult Patients With Pyruvate Kinase Deficiency Active, not recruiting NCT02476916 Phase 2 AG-348
45 Sirolimus for Autoimmune Disease of Blood Cells Active, not recruiting NCT00392951 Phase 1, Phase 2 sirolimus
46 NHLBI DIR LAMPOON Study: Intentional Laceration of the Anterior Mitral Leaflet to Prevent Left Ventricular Outflow Tract Obstruction During Transcatheter Mitral Valve Implantation Enrolling by invitation NCT03015194 Phase 2
47 Efficacy and Safety of HyQvia (Immunoglobulin 10% With Recombinant Hyaluronidase) in Multifocal Motor Neuropathy (MMN) Enrolling by invitation NCT02556437 Phase 2 HyQvia;Subcuvia
48 A Phase - IIa - IIb, Trial to Study the Safety, Tolerability and Efficacy of Memantine as a Long-term Treatment of SCD Not yet recruiting NCT03247218 Phase 2 Memantine Hydrochloride
49 Bioprosthetic or Native Aortic Scallop Intentional Laceration to Prevent Iatrogenic Coronary Artery Obstruction (BASILICA) Prospective Investigation Not yet recruiting NCT03381989 Phase 1, Phase 2
50 The Efficacy and Safety of Alemtuzumab in Auotoimmune Cytopenias Terminated NCT00472433 Phase 2 Alemtuzumab

Search NIH Clinical Center for Hemolytic Anemia

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Hemolytic Anemia cell therapies at LifeMap Discovery.

Cochrane evidence based reviews: anemia, hemolytic

Genetic Tests for Hemolytic Anemia

Genetic tests related to Hemolytic Anemia:

# Genetic test Affiliating Genes
1 Hemolytic Anemia 28

Anatomical Context for Hemolytic Anemia

MalaCards organs/tissues related to Hemolytic Anemia:

38
Heart, Bone, Bone Marrow, Liver, Spleen, Testes, B Cells

Publications for Hemolytic Anemia

Articles related to Hemolytic Anemia:

(show top 50) (show all 1459)
# Title Authors Year
1
Spurious thrombocytosis in the setting of hemolytic anemia and microcytosis secondary to extensive burn injury. ( 29391327 )
2018
2
Microangiopathic Hemolytic Anemia Following Three Different Species of Hump-Nosed Pit Viper (Genus: Hypnale) Envenoming in Sri Lanka. ( 29361387 )
2018
3
Successful treatment of refractory autoimmune hemolytic anemia after allogeneic hematopoietic stem cell transplantation with bortezomib. ( 29345206 )
2018
4
Life-threatening autoimmune warm hemolytic anemia following treatment for multiple sclerosis with alemtuzumab. ( 29359614 )
2018
5
Paraneoplastic Auto-immune Hemolytic Anemia: An Unusual Sequela of Enteric Duplication Cyst. ( 29277816 )
2018
6
Exacerbation of autoimmune hemolytic anemia induced by the first dose of programmed death-1 inhibitor pembrolizumab: a case report. ( 29340837 )
2018
7
Importance of the Average Glucose Level and Estimated Glycated Hemoglobin in a Diabetic Patient with Hereditary Hemolytic Anemia and Liver Cirrhosis. ( 29225250 )
2018
8
Durable responses in refractory autoimmune hemolytic anemia with alemtuzumab. ( 29334337 )
2018
9
Should Giant Cell Hepatitis With Autoimmune Hemolytic Anemia Be Considered a Pediatric Autoimmune Liver Disease? ( 29394216 )
2018
10
Ominous comorbidities: Small ventricular septal defect and warm autoimmune hemolytic anemia. ( 29440848 )
2018
11
Hemolytic anemia due to native valve subacute endocarditis with<i>Actinomyces israelii</i>infection. ( 29445480 )
2018
12
Simultaneous early-onset severe autoimmune hemolytic anemia and albuminuria during alemtuzumab treatment for multiple sclerosis. ( 29359617 )
2018
13
Methylene blue-induced Heinz body hemolytic anemia in a premature neonate. ( 29314195 )
2018
14
Autoimmune hemolytic anemia in solid organ transplantation-The role of immunosuppression. ( 28621877 )
2017
15
Microangiopathic hemolytic anemia caused by a signet-ring cell carcinoma of the intrahepatic bile duct. ( 28927252 )
2017
16
Therapeutic plasma exchange in refractory warm autoimmune hemolytic anemia. ( 28594138 )
2017
17
Diffuse Chorangiomatosis as a Cause of Cardiomegaly, Microangiopathic Hemolytic Anemia and Thrombocytopenia in a Newborn. ( 29227711 )
2017
18
Platelet satellitism in autoimmune hemolytic anemia. ( 28619392 )
2017
19
Steroid-Refractory Autoimmune Hemolytic Anemia with Massive Splenomegaly. ( 28389309 )
2017
20
A Rare Cause of Neonatal Hemolytic Anemia: Glutathione Synthetase Deficiency. ( 28267090 )
2017
21
Induction of IL-10 cytokine and the suppression of T cell proliferation by specific peptides from red cell band 3 and in vivo effects of these peptides on autoimmune hemolytic anemia in NZB mice. ( 28455817 )
2017
22
An Atypical Presentation of Chronic Atrophic Gastritis: Hemolytic Anemia and Mesenteric Panniculitis. ( 28758037 )
2017
23
Reliable assessment of the incidence of childhood autoimmune hemolytic anemia. ( 28748541 )
2017
24
Acute Kidney Injury and Hemolytic Anemia Secondary to Mycoplasma pneumoniae Infection. ( 28683450 )
2017
25
The first reported case of concurrent trimethoprim-sulfamethoxazole-induced immune hemolytic anemia and thrombocytopenia. ( 28905389 )
2017
26
Tumor necrosis factor gene polymorphisms in adult patients with autoimmune hemolytic anemia. ( 28111935 )
2017
27
Post-Babesiosis Warm Autoimmune Hemolytic Anemia. ( 28273010 )
2017
28
Microangiopathic Hemolytic Anemia - A Rare Presentation of Vitamin B12 Deficiency. ( 29071581 )
2017
29
Treatment of chronic lymphocytic leukemia/small lymphocytic lymphoma presenting simultaneously with acquired hemophilia and warm autoimmune hemolytic anemia. ( 28670081 )
2017
30
Coinheritance of Hb Bristol-Alesha [I^67(E11)Vala89Met; HBB: c.202G>A] and the I+212 Patchwork Allele in a Brazilian Child with Severe Congenital Hemolytic Anemia. ( 28670945 )
2017
31
Low-Dose Rituximab for Hemolytic Anemia Retreatment in a Patient With Systemic Lupus Erythematosus. ( 29232288 )
2017
32
Serum Thymidine Kinase 1, Canine-C-Reactive Protein, Haptoglobin, and Vitamin D Concentrations in Dogs with Immune-Mediated Hemolytic Anemia, Thrombocytopenia, and Polyarthropathy. ( 28804921 )
2017
33
Autoimmune hemolytic anemia associated with babesiosis. ( 28405337 )
2017
34
Diagnostic approaches for inherited hemolytic anemia in the genetic era. ( 28698843 )
2017
35
Immune Thrombocytopenic Purpura and Hemolytic Anemia Secondary to Hepatitis A. ( 28875001 )
2017
36
Neonatal nonimmune hemolytic anemia. ( 27861255 )
2017
37
Treatment of refractory autoimmune hemolytic anemia with venetoclax in relapsed chronic lymphocytic leukemia with del(17p). ( 28597168 )
2017
38
A Case of Idiopathic Pulmonary Hemosiderosis Presenting With Signs and Symptoms Mimicking Hemolytic Anemia. ( 27918350 )
2017
39
Neonatal hemolytic anemia does not always indicate thalassemia: a case report. ( 28899405 )
2017
40
Autoimmune Hemolytic Anemia Obscured by the Obstructive Jaundice Associated with IgG4-related Sclerosing Cholangitis in a Patient with Type 1 Autoimmune Pancreatitis: A Case Report and Review of the Literature. ( 29269682 )
2017
41
Rasburicase-induced Hemolytic Anemia in an Adolescent With Unknown Glucose-6-Phosphate Dehydrogenase Deficiency. ( 29290749 )
2017
42
Severe autoimmune hemolytic anemia during pegylated interferon plus ribavirin treatment for chronic hepatitis C: a case report. ( 28878911 )
2017
43
Microangiopathic hemolytic anemia due to ADAMTS-13 loss in idiopathic systemic capillary leak syndrome: comment. ( 28122158 )
2017
44
Prolonged Coagulopathy, Ecchymoses, and Microangiopathic Hemolytic Anemia Following Hump-Nosed Pit Viper (Hypnale hypnale) Bite in Sri Lanka. ( 28755820 )
2017
45
An unusual association between hemophagocytic lymphohistiocytosis, mixed connective tissue disease, and autoimmune hemolytic anemia: A case report. ( 28700492 )
2017
46
High prevalence of monoclonal gammopathy among patients with warm autoimmune hemolytic anemia. ( 28437873 )
2017
47
Cell-Free DNA and DNase Activity in Dogs with Immune-Mediated Hemolytic Anemia. ( 28833583 )
2017
48
Hemolytic anemia in alcoholic liver disease: Zieve syndrome: A case report and literature review. ( 29381966 )
2017
49
A case of pernicious anemia requiring differential diagnosis of autoimmune hemolytic anemia complication. ( 28948030 )
2017
50
Efficacy of bendamustine on thrombocytopenia and hemolytic anemia secondary to CD5-positive B-cell lymphoma with massive splenomegaly in a patient with rheumatoid arthritis. ( 29181179 )
2017

Variations for Hemolytic Anemia

ClinVar genetic disease variations for Hemolytic Anemia:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 HBB NM_000518.4(HBB): c.127T> C (p.Phe43Leu) single nucleotide variant Pathogenic rs33924146 GRCh38 Chromosome 11, 5226765: 5226765
2 HBB NM_000518.4(HBB): c.127T> G (p.Phe43Val) single nucleotide variant Pathogenic rs33924146 GRCh37 Chromosome 11, 5247995: 5247995

Expression for Hemolytic Anemia

Search GEO for disease gene expression data for Hemolytic Anemia.

Pathways for Hemolytic Anemia

Pathways related to Hemolytic Anemia according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.83 AK1 ALDOA G6PD GCLC GPI GSS
2
Show member pathways
12.63 ALDOA G6PD GPI HK1 PGK1 PKLR
3
Show member pathways
12.41 ALDOA GPI HK1 PGK1 PKLR
4 12.31 ALDOA G6PD HBB HK1
5
Show member pathways
11.76 ALDOA G6PD GPI HK1 PGK1 PKLR
6 11.69 ALDOA HK1 PGK1
7
Show member pathways
11.68 ALDOA HK1 PGK1 PKLR
8 11.47 ALDOA HK1 PGK1
9
Show member pathways
11.45 ALDOA G6PD GPI
10
Show member pathways
11.1 HBA2 HBB RHAG SLC4A1
11 10.61 PGK1 PKLR
12 10.13 G6PD GPI HK1 PGK1
13 10.11 G6PD GPI HK1

GO Terms for Hemolytic Anemia

Cellular components related to Hemolytic Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.7 AK1 ALDOA CD59 G6PD GPI GSS
2 ficolin-1-rich granule lumen GO:1904813 9.58 ALDOA GPI HBB
3 cytosol GO:0005829 9.47 AK1 ALDOA ANK1 G6PD GCLC GPI
4 endocytic vesicle lumen GO:0071682 9.37 HBA2 HBB
5 hemoglobin complex GO:0005833 9.32 HBA2 HBB
6 spectrin-associated cytoskeleton GO:0014731 9.26 ANK1 SPTB
7 haptoglobin-hemoglobin complex GO:0031838 9.16 HBA2 HBB

Biological processes related to Hemolytic Anemia according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 carbohydrate metabolic process GO:0005975 9.76 G6PD GPI HK1 PKLR
2 hydrogen peroxide catabolic process GO:0042744 9.54 HBA2 HBB
3 gluconeogenesis GO:0006094 9.54 ALDOA GPI PGK1
4 regulation of blood vessel size GO:0050880 9.52 GCLC HBB
5 glutathione biosynthetic process GO:0006750 9.51 GCLC GSS
6 response to cadmium ion GO:0046686 9.5 GCLC GPI GSS
7 oxygen transport GO:0015671 9.49 HBA2 HBB
8 erythrocyte maturation GO:0043249 9.48 EPB42 G6PD
9 bicarbonate transport GO:0015701 9.46 HBA2 HBB RHAG SLC4A1
10 response to xenobiotic stimulus GO:0009410 9.43 GCLC GSS
11 glucose 6-phosphate metabolic process GO:0051156 9.43 G6PD GPI HK1
12 cellular ion homeostasis GO:0006873 9.4 RHAG SLC4A1
13 glycolytic process GO:0006096 9.35 ALDOA GPI HK1 PGK1 PKLR
14 canonical glycolysis GO:0061621 9.02 ALDOA GPI HK1 PGK1 PKLR

Molecular functions related to Hemolytic Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATP binding GO:0005524 9.98 AK1 EPB42 GCLC GSS HK1 PGK1
2 catalytic activity GO:0003824 9.71 ALDOA GCLC HK1 PKLR
3 structural constituent of cytoskeleton GO:0005200 9.54 ANK1 EPB42 SPTB
4 peroxidase activity GO:0004601 9.46 HBA2 HBB
5 magnesium ion binding GO:0000287 9.46 GCLC GSS NT5C3A PKLR
6 oxygen carrier activity GO:0005344 9.32 HBA2 HBB
7 glucose binding GO:0005536 9.26 G6PD HK1
8 haptoglobin binding GO:0031720 8.96 HBA2 HBB
9 ankyrin binding GO:0030506 8.8 RHAG SLC4A1 SPTB

Sources for Hemolytic Anemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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