MCID: HML002
MIFTS: 60

Hemolytic Anemia malady

Blood, Immune categories

Summaries for Hemolytic Anemia

Sources:
64Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:64 Hemolytic anemia is a form of anemia due to hemolysis, the abnormal breakdown of red blood cells (RBCs),... more...

MalaCards: Hemolytic Anemia, also known as anemia hemolytic, is related to autoimmune hemolytic anemia and deficiency anemia. An important gene associated with Hemolytic Anemia is G6PD (glucose-6-phosphate dehydrogenase), and among its related pathways are Metabolism and MPS IIIC - Sanfilippo syndrome C. The drugs vitamin e and tocopherol acetate and the compounds glyceraldehyde 3-phosphate and lactate have been mentioned in the context of this disorder. Related mouse phenotypes are hematopoietic system and homeostasis/metabolism.

Description from OMIM:47 612631,266120

Aliases & Classifications for Hemolytic Anemia

Sources:
8Disease Ontology, 10DISEASES, 31LifeMap Discovery™, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt, 47OMIM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Blood, Immune


Aliases & Descriptions:

hemolytic anemia 8 10 31
anemia hemolytic 8 45
hemolytic anemias nos 8
hemolytic anemias 8
anemia, hemolytic 61


External Ids:

Disease Ontology8 DOID:583
MeSH35 D000743
NCIt40 C34376
ICD1025 D55-D59

Related Diseases for Hemolytic Anemia

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Hemolytic Anemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 330)
idRelated DiseaseScoreTop Affiliating Genes
1autoimmune hemolytic anemia32.0CD59, G6PD
2deficiency anemia31.5SPTA1, SPTB, SLC4A1, GPI, HK1, CD59
3congenital nonspherocytic hemolytic anemia31.2GPI, PKLR, G6PD
4pyruvate kinase deficiency31.2G6PD, PKLR
5hereditary spherocytosis30.9G6PD, EPB42, SLC4A1, SPTB, SPTA1
6systemic lupus erythematosus30.7ADA, CFI, GPI, CD59
7thalassemia30.6G6PD, SLC4A1, SPTB
8hereditary elliptocytosis30.5SPTA1, SPTB, SLC4A1, G6PD
9tuberculosis30.5GPI, ADA
10paroxysmal nocturnal hemoglobinuria30.4CD59, G6PD
11pyropoikilocytosis30.3SPTA1
12adenocarcinoma30.3GCLM, CD59, GPI, ADA
13sickle cell anemia30.2SPTB
14sickle cell disease30.0CFI, G6PD
15chronic myeloid leukemia30.0ADA, ALDOA, CD59, G6PD
16hepatitis a10.8
17autoimmune hepatitis10.8
18thrombocytopenia10.8
19hepatitis c10.8
20refractory anemia10.8
21warm antibody hemolytic anemia10.6
22autoimmune thrombocytopenic purpura10.5
23hepatitis e10.5
24mixed-type autoimmune hemolytic anemia10.5
25methemoglobinemia10.5
26glucosephosphate isomerase deficiency10.5
27primary biliary cirrhosis10.5
28t-cell leukemia10.5
29phosphoglycerate kinase deficiency10.5
30acute leukemia10.4
31cold agglutinin disease10.4
32hepatitis c virus10.4
33antiphospholipid syndrome10.4
34evans' syndrome10.4
35hepatitis d10.4
36leukemia, t-cell, chronic10.4
37drug-induced autoimmune hemolytic anemia10.4
38favism10.4
39common variable immunodeficiency10.4
40thrombotic thrombocytopenic purpura10.4
41iron deficiency anemia10.4
42ulcerative colitis10.4
43wilson disease10.4
44nonspherocytic hemolytic anemia due to hexokinase deficiency10.4
45autoimmune hemolytic anemia, warm type10.4
46hemoglobinuria10.3
47n syndrome10.3
48b cell deficiency10.3
49micro syndrome10.3
50thrombotic thrombocytopenic purpura, congenital10.3

Graphical network of the top 20 diseases related to Hemolytic Anemia:



Diseases related to hemolytic anemia

Clinical Features for Hemolytic Anemia

Sources:
47OMIM
See all sources

Clinical features from OMIM:

612631,266120

Drugs & Therapeutics for Hemolytic Anemia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Hemolytic Anemia

Drug clinical trials:

Search ClinicalTrials for Hemolytic Anemia

Search NIH Clinical Center for Hemolytic Anemia

Search CenterWatch for Hemolytic Anemia

Inferred drug relations via UMLS61/NDF-RT41:

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Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Hemolytic Anemia cell therapies at LifeMap Discovery.

Genetic Tests for Hemolytic Anemia

Anatomical Context for Hemolytic Anemia

Animal Models for Hemolytic Anemia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Hemolytic Anemia

Sources:
51PubMed
See all sources

Articles related to Hemolytic Anemia:

(show top 50)    (show all 1215)
idTitleAuthorsYear
1
I/GI^AI^I'I^0-Thalassemia: A Rare but Clinically Significant Cause of Hemolytic Anemia in Infants. (23128329)
2014
2
Hereditary hemolytic anemia in Korea from 2007 to 2011: A study by the Korean Hereditary Hemolytic Anemia Working Party of the Korean Society of Hematology. (24086942)
2013
3
Warm autoimmune hemolytic anemia secondary to Plasmodium ovale infection: a case report and review of the literature. (24148713)
2013
4
Warm Autoimmune Hemolytic Anemia with a Direct Antiglobulin Test Positive for C3 and Negative for IgG: A Case Study and Analytical Literature Review of Incidence and Severity. (23645992)
2013
5
Immature platelet fraction can help adjust therapy in refractory thrombotic microangiopathic hemolytic anemia cases. (23899959)
2013
6
Splenic infarction, warm autoimmune hemolytic anemia and antiphospholipid antibodies associated with systemic lupus erythematosus. (22623174)
2012
7
Diffuse nodular lymphoid hyperplasia of intestine in selective IgG 2 subclass deficiency, autoimmune thyroiditis, and autoimmune hemolytic anemia: case report and literature review. (23256128)
2012
8
Perinuclear antineutrophil cytoplasmic autoantibodies in dogs infected with various vector-borne pathogens and in dogs with immune-mediated hemolytic anemia. (22924722)
2012
9
Bortezomib: friend or foe of hemolytic anemia? (20562167)
2011
10
Direct antiglobulin test-negative autoimmune hemolytic anemia associated with HLA-haploidentical stem cell transplantation. (21472396)
2011
11
Immune-mediated hemolytic anemia and severe thrombocytopenia in dogs: 12 cases (2001-2008). (20636987)
2010
12
Both hemolytic anemia and malaria parasite-specific factors increase susceptibility to Nontyphoidal Salmonella enterica serovar typhimurium infection in mice. (20100860)
2010
13
Variants in the ITPA gene protect against ribavirin-induced hemolytic anemia and decrease the need for ribavirin dose reduction. (20547162)
2010
14
Passenger lymphocyte syndrome with or without immune hemolytic anemia in all Rh-positive recipients of lungs from rhesus alloimmunized donors: three new cases and a review of the literature. (19304114)
2009
15
Transient pure red blood cell aplasia as clinical presentation of congenital hemolytic anemia: a case report. (19829866)
2009
16
Drug-induced immune hemolytic anemia. (19236219)
2009
17
Hemolytic anemia: an unusual presentation of cor triatriatum sinistrum. (19423512)
2009
18
Severe autoimmune hemolytic anemia complicated with liver decompensation and invasive aspergillosis in a patient with chronic hepatitis C during treatment with peg-interferon-a and ribavirin. (19337648)
2009
19
C-reactive protein concentration in dogs with primary immune-mediated hemolytic anemia. (19392754)
2009
20
A 40-year-old man with hemolytic anemia, Ig deficiency, and bilateral pulmonary infiltrates. (18574299)
2008
21
Cardiac hypertrophy in anion exchanger 1-null mutant mice with severe hemolytic anemia. (17056673)
2007
22
Chronic non-spherocytic hemolytic anemia associated with severe neurological disease due to gamma-glutamylcysteine synthetase deficiency in a patient of Moroccan origin. (18024385)
2007
23
Evidence based therapeutic apheresis in autoimmune and other hemolytic anemias. (17898570)
2007
24
Autoimmune hemolytic anemias, Evans' syndromes, and pure red cell aplasia in non-Hodgkin lymphomas. (17577777)
2007
25
Chronic lymphocytic leukemia-associated autoimmune hemolytic anemia. (17577769)
2007
26
Copper deficiency pancytopenia with infectious complications after hemolytic anemia. (16944147)
2006
27
Severe autoimmune hemolytic anemia in a patient with chronic hepatitis C during treatment with peginterferon alfa-2a and ribavirin. (16785129)
2006
28
Autoimmune pathogenesis and autoimmune hemolytic anemia. (16041661)
2005
29
Functional analysis of pyrimidine 5'-nucleotidase mutants causing nonspherocytic hemolytic anemia. (15604219)
2005
30
Hyperuricemia and reticulocytopenia in association with autoimmune hemolytic anemia in two children. (15539377)
2004
31
Autoantibody formation after alloimmunization: are blood transfusions a risk factor for autoimmune hemolytic anemia? (14692969)
2004
32
Concomitant anuric post-streptococcal glomerulonephritis and autoimmune hemolytic anemia. (12740696)
2003
33
High-dose cyclophosphamide for refractory autoimmune hemolytic anemia. (12091370)
2002
34
Hemolytic anemia after acetaminophen overdose in patient with glucose-6-phosphate dehydrogenase deficiency. (11221636)
2001
35
Acute autoimmune hemolytic anemia following DTP vaccination: report of a fatal case and review of the literature. (11824181)
2001
36
PEG adsorption of autoantibodies and detection of alloantibodies in warm autoimmune hemolytic anemia. (11161239)
2001
37
Intensive plasma exchange for severe autoimmune hemolytic anemia in a four-month-old infant. (10611631)
1999
38
Restricted immunoglobulin VH region repertoire in chronic lymphocytic leukemia patients with autoimmune hemolytic anemia. (8611714)
1996
39
Hemolytic anemia due to abnormalities in erythrocyte nucleotide metabolism]. (8890581)
1996
40
Autoimmune hemolytic anemia in a patient with acute myelogenous leukemia treated with low-dose interleukin-2 after autologous bone marrow transplantation. (7606020)
1995
41
Rush hemolysis. A 'bite-cell' hemolytic anemia associated with volatile liquid nitrite use. (8081534)
1994
42
The role of anticardiolipin autoantibodies in the pathogenesis of autoimmune hemolytic anemia in systemic lupus erythematosus. (8014933)
1993
43
Recombinant erythropoietin as treatment for the late hyporegenerative anemia of Rh hemolytic disease. (1408538)
1992
44
An alanine-to-threonine substitution in protein 4.2 cDNA is associated with a Japanese form of hereditary hemolytic anemia (protein 4.2 Nippon). (1558976)
1992
45
Determination of erythrocyte pyruvate kinase deficiency in Basenjis with chronic hemolytic anemia. (2071475)
1991
46
Lymphosarcoma and associated immune-mediated hemolytic anemia and thrombocytopenia in horses. (6546561)
1984
47
A new glucose-6-phosphate dehydrogenase variant (G6PD Nagano) associated with congenital hemolytic anemia. (7166314)
1982
48
Hemoglobin Rush (beta 101 (g3) glutamine): a new unstable hemoglobin causing mild hemolytic anemia. (4129558)
1974
49
Glucose phosphate isomerase deficiency with congenital nonspherocytic hemolytic anemia: a new variant (type Nordhorn). I. Clinical and genetic studies. (4809302)
1974
50
Congenital hemolytic anemia in the Basenji dog due to erythrocyte pyruvate kinase deficiency. (4251418)
1971

Genetic Variations for Hemolytic Anemia

Expression for genes affiliated with Hemolytic Anemia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Hemolytic Anemia

Search GEO for disease gene expression data for Hemolytic Anemia.

Pathways for genes affiliated with Hemolytic Anemia

Sources:
54Reactome, 30KEGG, 12EMD Millipore, 38NCBI BioSystems Database, 50PharmGKB
See all sources

Compounds for genes affiliated with Hemolytic Anemia

Sources:
45Novoseek, 29IUPHAR, 24HMDB, 11DrugBank, 50PharmGKB
See all sources

Compounds related to Hemolytic Anemia according to GeneCards/GeneDecks:

(show all 25)
idCompoundScoreTop Affiliating Genes
1glyceraldehyde 3-phosphate4511.0ALDOA, G6PD, AK1, PRDX2, PKLR, GPI
2lactate4511.0G6PD, AK1, CD59, HK1, GPI, SLC4A1
3pyruvate4511.0BPGM, G6PD, AK1, PKLR, HK1, GPI
4atp45 2912.0G6PD, AK1, PRDX2, PKLR, CD59, HK1
5creatinine4511.0G6PD, AK1, PRDX2, HK1, GPI, CFI
6glucose4511.0STOM, AK1, CD59, GPI, CFI, SLC4A1
7lipid4510.9G6PD, STOM, RHAG, CD59, GPI, CFI
86-phosphogluconate4510.9G6PD, AK1, GPI, ADA
9oxygen45 2411.9GCLC, PRDX2, CD59, HK1, SPTB
10fructose-1,6-bisphosphate4510.9G6PD, GPI, ALDOA
11serine4510.8G6PD, STOM, PRDX2, PKLR, HK1, GPI
12cellulose acetate4510.8ADA, GPI, G6PD
13isocitrate4510.8G6PD, PRDX2, GPI
14ddamp4510.8ADA, AK1
15Alpha-D-Glucose-6-Phosphate1110.8GPI, HK1
16sucrose45 11 2412.8CD59, HK1, GPI, CFI
17adenylate4510.8G6PD, AK1, GPI, ALDOA, ADA
18alpha-ketoglutarate4510.7GPI, PKLR, G6PD
19diethylmaleate4510.7GCLM, GCLC
2023-diphosphoglycerate4510.6BPGM, G6PD
214-hydroxynonenal45 2411.6GCLM, GCLC
22glucose 6-phosphate45 2411.5GPI, HK1, G6PD
23sulfamethoxazole45 50 1112.5G6PD, GCLC
24mefloquine45 1111.4G6PD, STOM
25glycogen45 2411.3ALDOA, GPI, HK1, PKLR

GO Terms for genes affiliated with Hemolytic Anemia

Sources:
16Gene Ontology
See all sources

Cellular components related to Hemolytic Anemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:00582910.8ADA, GCLC, GCLM, G6PD, AK1, PRDX2
2glutamate-cysteine ligase complexGO:01710910.5GCLC, GCLM
3intrinsic to internal side of plasma membraneGO:03123510.5SPTA1, SPTB
4spectrin-associated cytoskeletonGO:01473110.4SPTA1, SPTB
5spectrinGO:00809110.2SPTA1, SPTB

Biological processes related to Hemolytic Anemia according to GeneCards/GeneDecks:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1small molecule metabolic processGO:04428111.0AK1, G6PD, GCLM, GCLC, RHAG, PKLR
2carbohydrate metabolic processGO:00597510.9ALDOA, GPI, HK1, PKLR, G6PD, BPGM
3glycolysisGO:00609610.9ALDOA, GPI, HK1, PKLR, BPGM
4glucose 6-phosphate metabolic processGO:05115610.9G6PD, HK1, GPI
5negative regulation of neuron apoptotic processGO:04352410.9GCLC, GCLM, PRDX2, GPI
6regulation of mitochondrial depolarizationGO:05190010.8GCLM, GCLC
7response to nitrosative stressGO:05140910.8GCLC, GCLM
8cysteine metabolic processGO:00653410.8GCLM, GCLC
9cellular ion homeostasisGO:00687310.8SLC4A1, RHAG
10porphyrin-containing compound biosynthetic processGO:00677910.8SPTA1, SPTB
11plasma membrane organizationGO:00700910.7SPTB, SPTA1
12glutamate metabolic processGO:00653610.7GCLM, GCLC
13response to oxidative stressGO:00697910.7PRDX2, GCLM, GCLC
14erythrocyte maturationGO:04324910.7EPB42, G6PD
15regulation of blood vessel sizeGO:05088010.7GCLC, GCLM
16glucose metabolic processGO:00600610.6ALDOA, GPI, PKLR
17regulation of cell shapeGO:00836010.6ALDOA, SPTA1, EPB42
18ATP biosynthetic processGO:00675410.5ALDOA, PKLR
19actin filament cappingGO:05169310.5SPTB, SPTA1
20glutathione biosynthetic processGO:00675010.4GCLC, GCLM
21cellular response to oxidative stressGO:03459910.2PRDX2, G6PD

Molecular functions related to Hemolytic Anemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein heterodimerization activityGO:04698210.5SPTA1, SPTB, GCLM, GCLC
2ankyrin bindingGO:03050610.5SPTB, SLC4A1, RHAG
3glutamate-cysteine ligase activityGO:00435710.4GCLM, GCLC
4structural constituent of cytoskeletonGO:00520010.2EPB42, SPTB, SPTA1

Products for genes affiliated with Hemolytic Anemia

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  • Proteins
  • Lysates
  • Antibodies

Sources for Hemolytic Anemia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet