MCID: HML002
MIFTS: 66

Hemolytic Anemia malady

Genetic diseases, Blood diseases, Rare diseases, Immune diseases, Metabolic diseases categories
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Summaries for Hemolytic Anemia

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Wikipedia:65 Hemolytic anemia is a form of anemia due to hemolysis, the abnormal breakdown of red blood cells (RBCs),... more...

MalaCards based summary: Hemolytic Anemia, also known as anemia hemolytic, is related to autoimmune hemolytic anemia and congenital hemolytic anemia. An important gene associated with Hemolytic Anemia is G6PD (glucose-6-phosphate dehydrogenase), and among its related pathways are Pentose Phosphate Pathway and Glutathione metabolism. The drugs vitamin e and tocopherol acetate and the compounds Beta-D-Glucose 6-phosphate and fructose-1,6-bisphosphate have been mentioned in the context of this disorder. Affiliated tissues include testes, liver and t cells, and related mouse phenotypes are liver/biliary system and immune system.

Descriptions from OMIM:46 612631,266120

Aliases & Classifications for Hemolytic Anemia

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Hemolytic Anemia, Aliases & Descriptions:

Name: Hemolytic Anemia 30 8 10
Anemia Hemolytic 8 44
 
Anemia, Hemolytic 62


Classifications:



External Ids:

Disease Ontology8 DOID:583
MeSH34 D000743
NCIt39 C34376

Related Diseases for Hemolytic Anemia

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Diseases in the Autoimmune Hemolytic Anemia family:

hemolytic anemia Congenital Hemolytic Anemia
Hemolytic Anemia Due to Band 3 Montefiore Hemolytic Anemia Due to Erythrocyte Adenosine Deaminase Overproduction

Diseases related to Hemolytic Anemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 378)
idRelated DiseaseScoreTop Affiliating Genes
1autoimmune hemolytic anemia32.6G6PD, CD59
2congenital hemolytic anemia31.7GPI, G6PD, PKLR
3pyruvate kinase deficiency31.7G6PD, PKLR
4congenital nonspherocytic hemolytic anemia31.5GPI, G6PD, PKLR
5malaria31.2G6PD
6hereditary spherocytosis31.1EPB42, G6PD
7hemoglobinuria31.1G6PD, CD59
8glucosephosphate dehydrogenase deficiency31.1G6PD, PKLR
9hereditary elliptocytosis30.9EPB42
10systemic lupus erythematosus30.8GPI, CD59, ADA
11paroxysmal nocturnal hemoglobinuria, somatic30.5G6PD, CD59
12acute lymphoblastic leukemia30.5ADA, G6PD, CD59
13aplastic anemia30.4PGK1, CD59
14gaucher's disease30.2ADA, PKLR
15chronic myeloid leukemia30.1G6PD, ADA, CD59
16adenocarcinoma30.0ADA, PGK1, CD59, GPI
17diabetes mellitus30.0PKLR, G6PD, HK1
18deficiency anemia29.4RHAG, G6PD, PGK1, GPI, PKLR, HK1
19breast cancer29.4PGK1, ADA, CD59, HK1, GPI, G6PD
20leukemia10.9
21hepatitis10.9
22thrombocytopenia10.8
23chronic lymphocytic leukemia10.8
24purpura10.7
25pure red-cell aplasia10.6
26hepatitis c10.6
27glucose phosphate isomerase deficiency10.6
28warm antibody hemolytic anemia10.6
29lupus erythematosus10.5
30mixed-type autoimmune hemolytic anemia10.5
31methemoglobinemia10.5
32phosphoglycerate kinase deficiency10.5
33primary biliary cirrhosis10.5
34hypertension10.5
35evans' syndrome10.5
36b-cell lymphomas10.4
37hodgkin's lymphoma10.4
38antiphospholipid syndrome10.4
39pneumonia10.4
40cold agglutinin disease10.4
41nonspherocytic hemolytic anemia due to hexokinase deficiency10.4
42drug-induced autoimmune hemolytic anemia10.4
43common variable immunodeficiency10.4
44glomerulonephritis10.4
45hematopoietic stem cell transplantation10.4
46ulcerative colitis10.4
47thrombotic thrombocytopenic purpura10.4
48colitis10.4
49hepatitis c virus10.4
50autoimmune hepatitis10.4

Graphical network of the top 20 diseases related to Hemolytic Anemia:



Diseases related to hemolytic anemia

Symptoms for Hemolytic Anemia

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Clinical features from OMIM:

612631,266120

Drugs & Therapeutics for Hemolytic Anemia

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Drug clinical trials:

Search ClinicalTrials for Hemolytic Anemia

Search NIH Clinical Center for Hemolytic Anemia

Inferred drug relations via UMLS62/NDF-RT40:

Show with subtypes

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Hemolytic Anemia cell therapies at LifeMap Discovery.

Genetic Tests for Hemolytic Anemia

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Anatomical Context for Hemolytic Anemia

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MalaCards organs/tissues related to Hemolytic Anemia:

32
Testes, Liver, T cells, B cells, Bone, Kidney, Bone marrow, Spleen, Lung, Heart, Thyroid, Myeloid, Endothelial, Brain, Spinal cord, Pancreas, Breast, Ovary, Cervix, Monocytes, Nk cells, Neutrophil

Animal Models for Hemolytic Anemia or affiliated genes

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MGI Mouse Phenotypes related to Hemolytic Anemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.7GCLC, HK1, ADA, GPI
2MP:00053877.1GPI, EPB42, ADA, PKLR, HK1, GCLC
3MP:00053976.2GPI, G6PD, EPB42, ADA, PKLR, RHAG
4MP:00053766.0CD59, GPI, G6PD, EPB42, ADA, AK1

Publications for Hemolytic Anemia

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Articles related to Hemolytic Anemia:

(show top 50)    (show all 1228)
idTitleAuthorsYear
1
Pure red-cell aplasia and autoimmune hemolytic anemia in a patient with acute hepatitis A. (25032187)
2014
2
Thrombotic thrombocytopenic purpura and other thrombotic microangiopathic hemolytic anemias: Diagnosis and classification. (24418304)
2014
3
Drug-induced immune hemolytic anemia: the last 30 years of changes. (25247622)
2014
4
Hb Youngstown [I^101(G3)Glua88a89a88Ala; HBB: c.305Aa88>a88C]: An Unstable Hemoglobin Variant Causing Severe Hemolytic Anemia. (25347256)
2014
5
A mixed-type autoimmune hemolytic anemia with immune thrombocytopenia related with myositis and post-transplantation lymphoproliferative disorder. (24013519)
2013
6
The first example of a patient with etoricoxib-induced immune hemolytic anemia. (22882551)
2013
7
Methemoglobinemia and hemolytic anemia after rasburicase administration in a child with leukemia. (21057874)
2013
8
SLE with diffuse alveolar hemorrhage, microangiopathic hemolytic anemia and acute renal failure. (22730045)
2012
9
Splenic infarction, warm autoimmune hemolytic anemia and antiphospholipid antibodies associated with systemic lupus erythematosus. (22623174)
2012
10
Low-dose rituximab in adult patients with idiopathic autoimmune hemolytic anemia: clinical efficacy and biologic studies. (22267606)
2012
11
Incidence of congenital hemolytic anemias in young cholelithiasis patients. (21086564)
2010
12
Trimethoprim-induced immune hemolytic anemia in a pediatric oncology patient presenting as an acute hemolytic transfusion reaction. (20589632)
2010
13
Treatment of immune-mediated hemolytic anemia with individually adjusted heparin dosing in dogs. (20384956)
2010
14
Autoimmune hemolytic anemia as a risk factor of poor outcome in patients with splenic marginal zone lymphoma. (19343544)
2009
15
The role of oxidative stress in hemolytic anemia. (18991647)
2008
16
Pulmonary hypertension associated with autoimmune hemolytic anemia: a case report. (16889843)
2007
17
Cardiac hypertrophy in anion exchanger 1-null mutant mice with severe hemolytic anemia. (17056673)
2007
18
Review: pharmacologic treatment of warm autoimmune hemolytic anemia. (18284301)
2007
19
Severe autoimmune hemolytic anemia after unrelated umbilical cord blood transplant for familial hemophagocytic lymphohistiocytosis: significant improvement after treatment with rituximab. (17279011)
2007
20
Management of cold agglutinin immune hemolytic anemia in pregnancy. (17666637)
2007
21
Autoimmune hemolytic anemia in an elderly patient with primary SjAPgren's syndrome. (16415556)
2005
22
Successful treatment with cyclosporine and high-dose gamma immunoglobulin for persistent parvovirus B19 infection in a patient with refractory autoimmune hemolytic anemia. (15540900)
2004
23
Hemolytic anemia and severe rhabdomyolysis caused by compound heterozygous mutations of the gene for erythrocyte/muscle isozyme of aldolase, ALDOA(Arg303X/Cys338Tyr). (14615364)
2004
24
A case of autoimmune hepatitis and autoimmune hemolytic anemia following hepatitis A infection. (14655068)
2003
25
Sinus histiocytosis with massive lymphadenopathy: complicated by autoimmune hemolytic anemia. (14620195)
2003
26
Autoimmune hemolytic anemia associated with Crohn's disease. (11854607)
2002
27
Myelodysplastic syndrome complicated by autoimmune hemolytic anemia: remission of refractory anemia following mycophenolate mofetil. (12483369)
2002
28
An adolescent with hemolytic anemia and coagulation disorders as manifestation of Wilson's disease, treated with liver transplantation]. (11234295)
2001
29
Severe Coombs'-negative autoimmune hemolytic anemia in a kidney transplant patient. (11799268)
2001
30
Hemolytic anemia after acetaminophen overdose in patient with glucose-6-phosphate dehydrogenase deficiency. (11221636)
2001
31
Eight novel mutations and consequences on mRNA and protein level in pyruvate kinase-deficient patients with nonspherocytic hemolytic anemia. (10679942)
2000
32
Molecular analysis of 29 pyruvate kinase-deficient patients from central Europe with hereditary hemolytic anemia. (9057665)
1997
33
Direct Coombs test-negative autoimmune hemolytic anemia and low-affinity IgG class antibodies. (15387763)
1997
34
Missense mutations in the human glutathione synthetase gene result in severe metabolic acidosis, 5-oxoprolinuria, hemolytic anemia and neurological dysfunction. (9215686)
1997
35
Hemolytic anemia as cause of a marked bilirubin increase in primary biliary cirrhosis]. (8925755)
1996
36
Autoimmune hemolytic anemia in a patient with idiopathic hypereosinophilia. (7639285)
1995
37
High cytokine serum levels in patients with autoimmune hemolytic anemia (AIHA). (7851962)
1994
38
Clinical features and splenic pathologic changes in patients with autoimmune hemolytic anemia and congenital hemolytic anemia. (8331977)
1993
39
Broad beans as a cause of acute hemolytic anemia]. (8519217)
1993
40
Homozygous hereditary elliptocytosis with hemolytic anemia. (6719166)
1984
41
G6PD San Francisco: a new variant of glucose-6-phosphate dehydrogenase associated with congenital nonspherocytic hemolytic anemia. (7353069)
1980
42
Congenital hemolytic anemia associated with dehydrated erythrocytes and increased potassium loss. (4851153)
1974
43
Animal model of human disease. Congenital hemolytic anemia. (4715956)
1973
44
Functionally abnormal pyruvate kinase in congenital hemolytic anemia. (5388241)
1969
45
Erythrocyte pyruvate kinase deficiency in non-spherocytic hemolytic anemia: a system of multiple genetic markers? (5658389)
1968
46
Microangiopathic hemolytic anemia caused by purpura fulminans. (5653626)
1968
47
Warm antibody hemolytic anemia; prolonged remission despite persistent positive Coombs test. (5310347)
1968
48
A case of congenital hemolytic anemia with hypersplenism. Remission of 24 years following splenectomy and recurrence due to an accessory spleen visualized by thoratrast. (14418071)
1960
49
Renal hemosiderosis in the hemolytic anemias: diagnosis by means of needle biopsy. (14415802)
1960
50
Congenital hemolytic anemia in the Negro. (15432084)
1950

Variations for Hemolytic Anemia

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Expression for genes affiliated with Hemolytic Anemia

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Expression patterns in normal tissues for genes affiliated with Hemolytic Anemia

Search GEO for disease gene expression data for Hemolytic Anemia.

Pathways for genes affiliated with Hemolytic Anemia

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Pathways related to Hemolytic Anemia according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
pentose phosphate pathway (non-oxidative branch)37
pentose phosphate pathway37
PRPP biosynthesis37
9.8G6PD, GPI
2
Show member pathways
glutathione-mediated detoxification I37
glutathione redox reactions I37
glutathione redox reactions II37
4-hydroxy-2-nonenal detoxification37
Glutathione metabolism60
Glutathione metabolism37
9.8GCLC, G6PD
3
Show member pathways
colanic acid building blocks biosynthesis37
N-acetylglucosamine degradation I37
CMP-N-acetylneuraminate biosynthesis I (eukaryotes)37
UDP-D-xylose and UDP-D-glucuronate biosynthesis37
N-acetylglucosamine degradation II37
UDP-N-acetyl-D-glucosamine biosynthesis II37
UDP-N-acetyl-D-galactosamine biosynthesis II37
GDP-L-fucose biosynthesis I (from GDP-D-mannose)37
9.7HK1, GPI
4
Show member pathways
9.6PKLR, HK1
59.5HK1, PGK1
6
Show member pathways
guanosine nucleotides de novo biosynthesis37
guanosine ribonucleotides de novo biosynthesis37
adenosine ribonucleotides de novo biosynthesis37
purine nucleotides de novo biosynthesis37
9.5ADA, AK1
79.5PKLR, PGK1
8
Show member pathways
One Carbon Metabolism37
dTMP de novo biosynthesis (mitochondrial)37
tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate37
Trans-sulfuration and one carbon metabolism37
methionine salvage37
Methionine metabolism60
9.5GCLC, ADA
9
Show member pathways
malate-aspartate shuttle37
glycogen biosynthesis II (from UDP-D-Glucose)37
9.2PKLR, PGK1, GPI
10
Show member pathways
TCA cycle37
pyruvate decarboxylation to acetyl CoA37
NAD phosphorylation and dephosphorylation37
TCA Cycle37
conversion of glucose to acetyl CoA and entry into the TCA cycle37
9.1PGK1, PKLR, HK1
11
Show member pathways
UTP and CTP dephosphorylation II37
ATP ITP metabolism60
purine deoxyribonucleosides salvage37
9.1ADA, AK1, PKLR
12
Show member pathways
glycolysis37
gluconeogenesis37
Glycolysis and Gluconeogenesis37
8.7HK1, PKLR, PGK1, GPI
13
Show member pathways
L-serine degradation37
pentose phosphate pathway (oxidative branch)37
formaldehyde oxidation II (glutathione-dependent)37
8.5GPI, G6PD, PGK1, PKLR, HK1
14
Show member pathways
8.5GPI, G6PD, PGK1, PKLR, HK1
15
Show member pathways
6.6GCLC, GPI, G6PD, PGK1, ADA, AK1

Compounds for genes affiliated with Hemolytic Anemia

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Sources:
24HMDB, 44Novoseek, 50PharmGKB, 11DrugBank, 2BitterDB, 28IUPHAR
See all sources

Compounds related to Hemolytic Anemia according to GeneCards/GeneDecks:

(show all 43)
idCompoundScoreTop Affiliating Genes
1Beta-D-Glucose 6-phosphate2410.2G6PD, GPI
2fructose-1,6-bisphosphate4410.2G6PD, GPI
3prpp4410.2G6PD, AK1
4sulfamethoxazole50 44 1112.1GCLC, G6PD
5starch4410.1G6PD, GPI
6isocitrate4410.1G6PD, GPI
7dADP2410.0AK1, PKLR
8actb4410.0PGK1, G6PD
9D-Glucose2410.0HK1, GPI
10glycerol 3-phosphate44 2411.0G6PD, GPI
11ddamp449.9AK1, ADA
12malate449.9G6PD, GPI
13purine nucleoside449.9G6PD, ADA
14glucose 6-phosphate44 2410.8GPI, G6PD, HK1
15phosphocreatine44 2410.8AK1, ADA
16alpha-ketoglutarate449.8GPI, G6PD, PKLR
17formate449.8ADA, G6PD
18sucrose44 24 1111.8CD59, HK1, GPI
19azathioprine44 2 50 1112.8G6PD, PGK1, CD59
202-deoxyglucose44 1110.7HK1, G6PD
21cellulose acetate449.6GPI, G6PD, ADA
22aspirin44 50 28 2412.6CD59, ADA, G6PD
23carbon449.6ADA, G6PD, GPI
24ribavirin44 50 1111.6G6PD, ADA
25glycerol44 24 1111.5HK1, ADA, G6PD
26Ammonia249.5RHAG, ADA
27hypoxanthine44 24 1111.5ADA, PGK1, G6PD
28glycogen44 2410.4GPI, PKLR, HK1
29superoxide44 2410.4CD59, PGK1, G6PD, GPI
306-phosphogluconate449.3GPI, G6PD, ADA, AK1
31fatty acid449.3CD59, HK1, PKLR
32adenylate449.3GPI, G6PD, ADA, AK1
33vitamin b12449.3ADA, G6PD
34paclitaxel44 50 1111.2ADA, PGK1, G6PD
35Adenosine triphosphate24 1110.0PGK1, AK1, PKLR, GCLC
36glyceraldehyde 3-phosphate449.0GPI, G6PD, PGK1, AK1, PKLR
37oxygen44 2410.0CD59, GCLC, HK1, PGK1, G6PD
38creatinine448.9HK1, AK1, ADA, G6PD, GPI
39adp44 28 2410.8GCLC, HK1, PKLR, AK1, PGK1
40pyruvate448.6GPI, G6PD, PGK1, AK1, PKLR, HK1
41glucose448.3GPI, G6PD, PGK1, AK1, PKLR, HK1
42lactate448.1CD59, GPI, G6PD, PGK1, ADA, AK1
43atp44 289.0G6PD, PGK1, ADA, AK1, PKLR, HK1

GO Terms for genes affiliated with Hemolytic Anemia

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Cellular components related to Hemolytic Anemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular vesicular exosomeGO:0700627.9GPI, G6PD, PGK1, AK1, PKLR, CD59
2plasma membraneGO:0058867.5CD59, RHAG, AK1, ADA, EPB42, GPI
3cytosolGO:0058297.0GCLC, GPI, G6PD, PGK1, ADA, AK1

Biological processes related to Hemolytic Anemia according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1glucose 6-phosphate metabolic processGO:0511569.6HK1, G6PD, GPI
2response to heatGO:0094089.5GCLC, PKLR
3nucleobase-containing small molecule metabolic processGO:0550869.5AK1, ADA
4erythrocyte maturationGO:0432499.4G6PD, EPB42
5gluconeogenesisGO:0060949.3PGK1, GPI
6glucose metabolic processGO:0060069.2PKLR, PGK1, GPI
7glycolytic processGO:0060968.9GPI, PGK1, PKLR, HK1
8carbohydrate metabolic processGO:0059758.6GPI, G6PD, PGK1, PKLR, HK1
9small molecule metabolic processGO:0442816.8GCLC, GPI, G6PD, PGK1, ADA, AK1

Molecular functions related to Hemolytic Anemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ATP bindingGO:0055247.6GCLC, HK1, PKLR, AK1, EPB42, PGK1

Products for genes affiliated with Hemolytic Anemia

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  • Antibodies
  • Proteins
  • Lysates

Sources for Hemolytic Anemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet