MCID: HML002
MIFTS: 61

Hemolytic Anemia

Categories: Blood diseases, Immune diseases, Rare diseases, Genetic diseases, Metabolic diseases

Aliases & Classifications for Hemolytic Anemia

MalaCards integrated aliases for Hemolytic Anemia:

Name: Hemolytic Anemia 38 12 29 14
Anemia, Hemolytic 42 69
Anemia Hemolytic 12 52

Classifications:



External Ids:

Disease Ontology 12 DOID:583
ICD10 33 D55-D59
MeSH 42 D000743
NCIt 47 C34376
UMLS 69 C0002878

Summaries for Hemolytic Anemia

MalaCards based summary : Hemolytic Anemia, also known as anemia, hemolytic, is related to pyruvate kinase deficiency and heinz body anemia, and has symptoms including icterus An important gene associated with Hemolytic Anemia is HBB (Hemoglobin Subunit Beta), and among its related pathways/superpathways are Metabolism and Glycosaminoglycan metabolism. The drugs Iron and Omeprazole have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and liver, and related phenotypes are Increased simian virus 40 (SV40) infection and hematopoietic system

Wikipedia : 72 Hemolytic anemia or haemolytic anaemia is a form of anemia due to hemolysis, the abnormal breakdown of... more...

Related Diseases for Hemolytic Anemia

Diseases in the Hemolytic Anemia family:

Congenital Hemolytic Anemia Autoimmune Hemolytic Anemia
Hemolytic Anemia Due to Band 3 Montefiore Hemolytic Anemia Due to Erythrocyte Adenosine Deaminase Overproduction

Diseases related to Hemolytic Anemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 412)
id Related Disease Score Top Affiliating Genes
1 pyruvate kinase deficiency 33.3 G6PD HBA2 PKLR SLC4A1
2 heinz body anemia 31.5 AK1 HBA2 HBB
3 kernicterus 29.8 ANK1 SLC4A1 SPTB
4 malaria 28.5 ADAMTS13 G6PD HBA2 HBB PKLR SLC4A1
5 hepatitis 24.0 ADAMTS13 AK1 ALDOA ANK1 CD59 EPB42
6 autoimmune hemolytic anemia 12.5
7 hemolytic anemia due to hexokinase deficiency 12.3
8 congenital hemolytic anemia 12.3
9 warm antibody hemolytic anemia 12.3
10 hemolytic anemia due to g6pd deficiency 12.3
11 hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency 12.2
12 hemolytic anemia due to adenylate kinase deficiency 12.2
13 hemolytic anemia, nonspherocytic, due to glucose phosphate isomerase deficiency 12.2
14 hemolytic anemia due to triosephosphate isomerase deficiency 12.2
15 hemolytic anemia, cd59-mediated, with or without immune-mediated polyneuropathy 12.2
16 hemolytic anemia due to glutathione synthetase deficiency 12.1
17 hemolytic anemia due to glutathione peroxidase deficiency 12.1
18 congenital nonspherocytic hemolytic anemia 12.1
19 mixed-type autoimmune hemolytic anemia 12.0
20 drug-induced autoimmune hemolytic anemia 12.0
21 autoimmune hemolytic anemia, warm type 11.9
22 hemolytic anemia, lethal congenital nonspherocytic, with genital and other abnormalities 11.9
23 hemolytic anemia due to glutathione reductase deficiency 11.9
24 hereditary spherocytosis 11.8
25 hemolytic anemia due to erythrocyte adenosine deaminase overproduction 11.8
26 hemolytic anemia due to glyceraldehyde-3-phosphate dehydrogenase deficiency 11.8
27 hemolytic anemia due to band 3 montefiore 11.8
28 neonatal autoimmune hemolytic anemia 11.8
29 autoimmune hemolytic anemia-autoimmune thrombocytopenia-primary immunodeficiency syndrome 11.8
30 rh-null regulator type related hemolytic anemia 11.8
31 thrombotic thrombocytopenic purpura, familial 11.7
32 renal tubular acidosis, distal, ar 11.7
33 evans' syndrome 11.7
34 glucose phosphate isomerase deficiency 11.7
35 cold agglutinin disease 11.7
36 anemia, hemolytic, due to umph1 deficiency 11.7
37 glut1 deficiency syndrome 2, childhood onset 11.6
38 hemolytic-uremic syndrome 11.6
39 paroxysmal cold hemoglobinuria 11.6
40 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 11.5
41 phosphoglycerate kinase deficiency 11.5
42 anemia, hemolytic, rh-null, regulator type 11.5
43 erythrocytosis due to bisphosphoglycerate mutase deficiency 11.4
44 glucosephosphate dehydrogenase deficiency 11.4
45 pyropoikilocytosis 11.3
46 glutathione synthetase deficiency 11.3
47 babesiosis 11.3
48 thrombotic thrombocytopenic purpura 11.2
49 dehydrated hereditary stomatocytosis with or without pseudohyperkalemia and/or perinatal edema 11.2
50 hemoglobinuria 11.1

Graphical network of the top 20 diseases related to Hemolytic Anemia:



Diseases related to Hemolytic Anemia

Symptoms & Phenotypes for Hemolytic Anemia

UMLS symptoms related to Hemolytic Anemia:


icterus

GenomeRNAi Phenotypes related to Hemolytic Anemia according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased simian virus 40 (SV40) infection GR00356-A-2 8.8 HK1 PGK1 PKLR

MGI Mouse Phenotypes related to Hemolytic Anemia:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.93 ADAMTS13 ANK1 CD59 EPB42 G6PD GPI
2 homeostasis/metabolism MP:0005376 9.77 CD59 EPB42 G6PD GCLC GPI HK1
3 mortality/aging MP:0010768 9.4 ADAMTS13 ANK1 CD59 G6PD GCLC GPI

Drugs & Therapeutics for Hemolytic Anemia

Drugs for Hemolytic Anemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 325)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iron Approved Phase 4,Phase 3,Phase 2 7439-89-6 23925
2
Omeprazole Approved, Investigational, Vet_approved Phase 4,Phase 1 73590-58-6 4594
3
Nitric Oxide Approved Phase 4,Phase 3,Phase 2,Phase 1 10102-43-9 145068
4
Hydroxyurea Approved Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1 127-07-1 3657
5
Peginterferon alfa-2a Approved, Investigational Phase 4,Phase 2 198153-51-4 5360545
6
Ribavirin Approved Phase 4,Phase 3,Phase 2 36791-04-5 37542
7
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
8
Mannitol Approved, Investigational Phase 4,Phase 3 69-65-8 453 6251
9
Prilocaine Approved Phase 4 721-50-6 4906
10 Racepinephrine Approved Phase 4
11
Zoledronic acid Approved Phase 4 118072-93-8 68740
12
Deferasirox Approved, Investigational Phase 4,Phase 3,Phase 2 201530-41-8 5493381
13
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
14
Deferiprone Approved Phase 4 30652-11-0 2972
15
Deferoxamine Approved, Investigational Phase 4,Phase 2 70-51-9 2973
16
Amodiaquine Approved Phase 4,Phase 1,Phase 2 86-42-0 2165
17
Proguanil Approved Phase 4,Phase 3,Phase 1,Phase 2 500-92-5 4923
18
Pyrimethamine Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 58-14-0 4993
19
Sulfadoxine Approved Phase 4,Phase 3,Phase 1,Phase 2 2447-57-6 17134
20
Metformin Approved Phase 4,Early Phase 1 657-24-9 14219 4091
21
Desogestrel Approved Phase 4 54024-22-5 40973
22
Etonogestrel Approved, Investigational Phase 4 54048-10-1 40976 6917715
23
Ibuprofen Approved Phase 4 15687-27-1 3672
24
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
25 Antioxidants Phase 4,Phase 3,Phase 2,Phase 1
26
Bilirubin Phase 4 635-65-4 5280352
27 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1
28 Protective Agents Phase 4,Phase 3,Phase 2,Phase 1
29 Antacids Phase 4,Phase 1
30 Anti-Ulcer Agents Phase 4,Phase 1
31 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1
32
Proton pump inhibitors Phase 4,Phase 1
33 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
34 Antimetabolites Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
35 Liver Extracts Phase 4,Phase 3,Phase 2
36 Antibodies Phase 4,Phase 3,Phase 2
37 Immunoglobulins Phase 4,Phase 3,Phase 2
38 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
39 Hormone Antagonists Phase 4,Phase 3,Phase 2
40 Hormones Phase 4,Phase 3,Phase 2
41 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2
42 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1
43 Antiparasitic Agents Phase 4,Phase 3,Phase 2,Phase 1
44 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1
45 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
46 Vasodilator Agents Phase 4,Phase 2,Phase 1,Early Phase 1
47 Antiviral Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
48 Interferon-alpha Phase 4,Phase 3,Phase 2
49 interferons Phase 4,Phase 3,Phase 2
50 diuretics Phase 4

Interventional clinical trials:

(show top 50) (show all 361)

id Name Status NCT ID Phase Drugs
1 Efficacy of Yinzhihuang Oral Liquid on Indirect Bilirubin of Neonates With Glucose-6-phosphate Dehydrogenase Deficiency Unknown status NCT02594904 Phase 4 Yinzhihuang Oral Liquid
2 Evaluation of the Efficacy in Decreasing Iron Absorption in Patients With Congenital Dyserythropoietic Anemia Type I by Treatment With LOSEC Unknown status NCT01795794 Phase 4 omeprazole
3 Retreatment of Dialysis Patients With Chronic Hepatitis C With Pegylated Interferon Alfa-2a Plus Low Dose Ribavirin Completed NCT00491179 Phase 4 Pegylated interferon alfa-2a and ribavirin;Pegylated interferon alfa-2a and ribavirin
4 Pegylated Interferon Alfa-2a Plus Low Dose Ribavirin for Treatment-Naïve Hemodialysis Patients With Chronic Hepatitis C Completed NCT00491244 Phase 4 Peginterferon alfa-2a and ribavirin;Peginterferon alfa-2a
5 Evaluation of Ureteral Patency in the Post-indigo Carmine Era Completed NCT02677623 Phase 4 Pyridium;Sodium Fluorescein;Mannitol
6 Low-Dose Peginterferon and Ribavirin to Treat Chronic Hepatitis C in Patients Infected With HCV Genotype 2 or 3 Completed NCT00056862 Phase 4 Peginterferon alfa-2a;Peginterferon alfa-2a;Ribavirin
7 Pegylated Interferon and Ribavirin to Treat Chronic Hepatitis C With and Without Kidney Disease Completed NCT00028093 Phase 4 Peginterferon alfa-2a with Ribavirin;Peginterferon alfa-2a
8 Long-Term Therapy With Ribavirin for Chronic Hepatitis C Completed NCT00001854 Phase 4 Ribavirin
9 Efficacy of High-dose Intravenous Immunoglobulin Therapy for Hyperbilirubinemia Due Rh Hemolytic Disease Completed NCT00288600 Phase 4 Intravenous Immunoglobulin;Normal saline solution
10 Evaluation of Efficacy of Zoledronic Acid in Patients With Haemoglobin Syndromes (Thalassemia and Sicle Cell Anaemia) and Risk of Skeletal Events Completed NCT00346242 Phase 4 Zoledronic Acid
11 This Study Will Evaluate Efficacy and Safety of Deferasirox in Patients With Myelodysplastic Syndromes (MDS), Thalassemia and Rare Anemia Types Having Transfusion-induced Iron Overload. Completed NCT01250951 Phase 4 Deferasirox
12 Evaluating the Efficacy of Deferasirox in Transfusion Dependent Chronic Anaemias (Myelodysplastic Syndrome, Beta-thalassaemia Patients) With Chronic Iron Overload Completed NCT00564941 Phase 4 deferasirox
13 An Epidemiological Study to Assess Iron Overload Using MRI in Patients With Transfusional Siderosis (TIMES Study) Completed NCT01736540 Phase 4
14 Intranasal Fentanyl for Initial Treatment of a Vaso-occlusive Crisis Completed NCT01482091 Phase 4 Fentanyl Citrate;Normal Saline
15 Study Assessing an Algorithm-based Strategy of Eculizumab Discontinuation in Children and Adults With aHUS Recruiting NCT02574403 Phase 4 eculizumab
16 Efficacy and Safety of Ferriprox® in Patients With Sickle Cell Disease or Other Anemias Recruiting NCT02041299 Phase 4 Deferiprone;Deferoxamine
17 Contraception in Women With Sickle Cell Disease Active, not recruiting NCT02594462 Phase 4 etonogestrel-releasing implant contraceptive
18 Risk Clinical Stratification of Sickle Cell Disease in Nigeria, Assessment of Efficacy/Safety of Hydroxyurea Treatment Active, not recruiting NCT02149537 Phase 4 hydroxyurea
19 Long-term Safety and Efficacy of Ferriprox® in Iron Overloaded Patients With Sickle Cell Disease or Other Anemias Enrolling by invitation NCT02443545 Phase 4 Deferiprone
20 Eval. of Potential Predictors of Disease Progression in Patients With aHUS Including Genetics, Biomarkers and Treatment Enrolling by invitation NCT02614898 Phase 4
21 Mobile-Directly Observed Therapy on Adherence to Hydroxyurea Enrolling by invitation NCT02844673 Phase 4 Hydroxyurea
22 The Potential Hepatoprotective Effect of Metformin in Patients With Beta Thalassemia Major Not yet recruiting NCT02984475 Phase 4 Metformin
23 Enhancing Preventive Therapy of Malaria In Children With Sickle Cell Anemia in East Africa (EPiTOMISE) Not yet recruiting NCT03178643 Phase 4 Proguanil Oral Tablet;Sulfadoxine/Pyrimethanine-Amodiaquine (SP-AQ);Dihydroartemisinin-Piperaquine (DP)
24 Ketorolac Versus Ibuprofen to Treat Painful Episodes of Sickle Cell Disease Terminated NCT00115336 Phase 4 Intravenous Ketorolac;Ibuprofen
25 Endothelial Function in Patients With Sickle Cell Anemia Before and After Sildenafil Withdrawn NCT00937144 Phase 4 Viagra (Sildenafil);placebo
26 Rituximab in Auto-Immune Hemolytic Anemia Unknown status NCT01181154 Phase 3 rituximab (Mabthera®);Placebo
27 Long-Term Effects of Hydroxyurea in Children With Sickle Cell Anemia (The BABY HUG Follow-up Study) Unknown status NCT00890396 Phase 3
28 Prednisolone +/- Addition of Anti-CD20 Antibody, Rituximab, in Patients With Immune Hemolytic Anemia Completed NCT01134432 Phase 3 prednisolone + mabthera;Prednisolone
29 Combination Drug Therapy for Patients With Hepatitis C Completed NCT00001729 Phase 3 Ribavirin
30 Eight Week Primaquine Regimen for the Treatment of Vivax Malaria Completed NCT00158587 Phase 3 primaquine
31 Doppler or Amniocentesis to Predict Fetal Anemia Completed NCT00295516 Phase 3
32 Lapdap and Coartemether for Uncomplicated Malaria Completed NCT00118794 Phase 3 Chlorproguanil-dapsone (Lapdap);Lumefantrine-artemether (Coartemether )
33 Study to Assess the Incidence of Hemolysis, Safety, and Efficacy of Tafenoquine (SB-252263, WR238605) Versus Primaquine in Subjects With Plasmodium Vivax Malaria Completed NCT02216123 Phase 3 Tafenoquine;Tafenoquine Placebo;Chloroquine;Primaquine;Primaquine Placebo
34 Alemtuzumab and Rituximab in the Treatment of Refractory Autoimmune Cytopenias Completed NCT00749112 Phase 2, Phase 3 Alemtuzumab, Rituximab
35 Eculizumab to Treat Paroxysmal Nocturnal Hemoglobinuria Completed NCT00130000 Phase 3 Eculizumab
36 Multicenter Study of Hydroxyurea in Patients With Sickle Cell Anemia (MSH) Completed NCT00000586 Phase 3 hydroxyurea
37 Hydroxyurea to Prevent Organ Damage in Children With Sickle Cell Anemia Completed NCT00006400 Phase 3 Hydroxyurea;Placebo
38 A Phase III Safety and Efficacy Study of L-Glutamine to Treat Sickle Cell Disease or Sickle βo-thalassemia Completed NCT01179217 Phase 3 L-glutamine;Placebo
39 Study of Safety in Hemolytic Paroxysmal Nocturnal Hemoglobinuria (PNH) Patients Treated With Eculizumab Completed NCT00122304 Phase 3 eculizumab
40 Sulfadoxine- Pyrimethamine Versus Weekly Chloroquine for Malaria Prevention in Children With Sickle Cell Anemia Completed NCT00399074 Phase 3 sulfadoxine pyrimethamine
41 Safety and Efficacy Study of Eculizumab in Shiga-Toxin Producing Escherichia Coli Hemolytic-Uremic Syndrome (STEC-HUS) Completed NCT01410916 Phase 2, Phase 3 Eculizumab (Soliris®)
42 MAST - Magnesium for Sickle Cell Acute Crisis in Children Completed NCT00313963 Phase 3 Magnesium Sulfate;Normal Saline
43 L-Arginine and Sickle Cell Disease Completed NCT01142219 Phase 3 L-arginine;Placebo
44 Phase III Randomized Study of Poloxamer 188 for Vaso-Occlusive Crisis of Sickle Cell Disease Completed NCT00004408 Phase 3 poloxamer 188
45 Stroke Prevention in Sickle Cell Anemia (STOP 1) Completed NCT00000592 Phase 3
46 Extension Study of Eculizumab in Patients With Transfusion Dependent Paroxysmal Nocturnal Hemoglobinuria (PNH) Completed NCT00122317 Phase 3 eculizumab
47 Stroke Prevention in Sickle Cell Anemia (STOP 2) Completed NCT00006182 Phase 3
48 Silent Cerebral Infarct Transfusion Multi-Center Clinical Trial Completed NCT00072761 Phase 3
49 N-Acetylcysteine in Patients With Sickle Cell Disease Completed NCT01849016 Phase 3 N-Acetylcysteine;Placebo
50 hATG+CsA vs hATG+CsA+Eltrombopag for SAA Recruiting NCT02099747 Phase 3 hATG;CsA;Eltrombopag

Search NIH Clinical Center for Hemolytic Anemia

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Hemolytic Anemia cell therapies at LifeMap Discovery.

Cochrane evidence based reviews: anemia, hemolytic

Genetic Tests for Hemolytic Anemia

Genetic tests related to Hemolytic Anemia:

id Genetic test Affiliating Genes
1 Hemolytic Anemia 29

Anatomical Context for Hemolytic Anemia

MalaCards organs/tissues related to Hemolytic Anemia:

39
Bone, Bone Marrow, Liver, Kidney, T Cells, Testes, B Cells

Publications for Hemolytic Anemia

Articles related to Hemolytic Anemia:

(show top 50) (show all 1437)
id Title Authors Year
1
Immune Thrombocytopenic Purpura and Hemolytic Anemia Secondary to Hepatitis A. ( 28875001 )
2017
2
Coinheritance of Hb Bristol-Alesha [I^67(E11)Vala89Met; HBB: c.202G>A] and the I+212 Patchwork Allele in a Brazilian Child with Severe Congenital Hemolytic Anemia. ( 28670945 )
2017
3
Microangiopathic hemolytic anemia caused by a signet-ring cell carcinoma of the intrahepatic bile duct. ( 28927252 )
2017
4
Treatment of refractory autoimmune hemolytic anemia with venetoclax in relapsed chronic lymphocytic leukemia with del(17p). ( 28597168 )
2017
5
Parvovirus B19 infection associated with hemolytic anemia and cranial polyneuropathy. ( 28831691 )
2017
6
Diagnostic approaches for inherited hemolytic anemia in the genetic era. ( 28698843 )
2017
7
Serum Thymidine Kinase 1, Canine-C-Reactive Protein, Haptoglobin, and Vitamin D Concentrations in Dogs with Immune-Mediated Hemolytic Anemia, Thrombocytopenia, and Polyarthropathy. ( 28804921 )
2017
8
Cell-Free DNA and DNase Activity in Dogs with Immune-Mediated Hemolytic Anemia. ( 28833583 )
2017
9
Successful treatment of tacrolimus-related pure red cell aplasia and autoimmune hemolytic anemia with rituximab in a pediatric cardiac transplant patient. ( 28598573 )
2017
10
Immune Hemolytic Anemia (Paroxysmal Cold Hemoglobinuria) Preceding Burkitt Lymphoma in a 12-Year-Old Child. ( 27879544 )
2017
11
Treatment of chronic lymphocytic leukemia/small lymphocytic lymphoma presenting simultaneously with acquired hemophilia and warm autoimmune hemolytic anemia. ( 28670081 )
2017
12
An unusual association between hemophagocytic lymphohistiocytosis, mixed connective tissue disease, and autoimmune hemolytic anemia: A case report. ( 28700492 )
2017
13
Neonatal nonimmune hemolytic anemia. ( 27861255 )
2017
14
A Case of Idiopathic Pulmonary Hemosiderosis Presenting With Signs and Symptoms Mimicking Hemolytic Anemia. ( 27918350 )
2017
15
The first reported case of concurrent trimethoprim-sulfamethoxazole-induced immune hemolytic anemia and thrombocytopenia. ( 28905389 )
2017
16
Autoimmune hemolytic anemia associated with babesiosis. ( 28405337 )
2017
17
High prevalence of monoclonal gammopathy among patients with warm autoimmune hemolytic anemia. ( 28437873 )
2017
18
Neonatal hemolytic anemia does not always indicate thalassemia: a case report. ( 28899405 )
2017
19
An Atypical Presentation of Chronic Atrophic Gastritis: Hemolytic Anemia and Mesenteric Panniculitis. ( 28758037 )
2017
20
Microangiopathic hemolytic anemia due to ADAMTS-13 loss in idiopathic systemic capillary leak syndrome: comment. ( 28122158 )
2017
21
Rituximab in refractory autoimmune hemolytic anemia in systemic lupus erythematosus. ( 28870533 )
2017
22
Thyroid storm and warm autoimmune hemolytic anemia. ( 28870408 )
2017
23
A case of pernicious anemia requiring differential diagnosis of autoimmune hemolytic anemia complication. ( 28948030 )
2017
24
Platelet satellitism in autoimmune hemolytic anemia. ( 28619392 )
2017
25
Autoimmune hemolytic anemia associated with trimethoprim-sulfamethoxazole use. ( 28596226 )
2017
26
Autoimmune hemolytic anemia in solid organ transplantation-The role of immunosuppression. ( 28621877 )
2017
27
Steroid-Refractory Autoimmune Hemolytic Anemia with Massive Splenomegaly. ( 28389309 )
2017
28
A novel PGK1 mutation associated with neurological dysfunction and the absence of episodes of hemolytic anemia or myoglobinuria. ( 28580215 )
2017
29
High Prevalence of ITPA Alleles Associated with Ribavirin-Induced Hemolytic Anemia Among Mexican Population. ( 28233743 )
2017
30
Induction of IL-10 cytokine and the suppression of T cell proliferation by specific peptides from red cell band 3 and in vivo effects of these peptides on autoimmune hemolytic anemia in NZB mice. ( 28455817 )
2017
31
Severe autoimmune hemolytic anemia during pegylated interferon plus ribavirin treatment for chronic hepatitis C: a case report. ( 28878911 )
2017
32
Reliable assessment of the incidence of childhood autoimmune hemolytic anemia. ( 28748541 )
2017
33
Congenital Hemolytic Anemia. ( 28189176 )
2017
34
Acute Kidney Injury and Hemolytic Anemia Secondary to Mycoplasma pneumoniae Infection. ( 28683450 )
2017
35
Autoimmune Hemolytic Anemia in Plasmodium vivax Malaria. ( 28290054 )
2017
36
Post-Babesiosis Warm Autoimmune Hemolytic Anemia. ( 28273010 )
2017
37
A rare case of autoimmune hemolytic anemia. ( 28751361 )
2017
38
Microangiopathic hemolytic anemia due to ADAMTS-13 loss in idiopathic systemic capillary leak syndrome: reply. ( 28182327 )
2017
39
Therapeutic plasma exchange in refractory warm autoimmune hemolytic anemia. ( 28594138 )
2017
40
Prolonged Coagulopathy, Ecchymoses, and Microangiopathic Hemolytic Anemia Following Hump-Nosed Pit Viper (Hypnale hypnale) Bite in Sri Lanka. ( 28755820 )
2017
41
A Rare Cause of Neonatal Hemolytic Anemia: Glutathione Synthetase Deficiency. ( 28267090 )
2017
42
Warm autoimmune hemolytic anemia: experience from a single referral center in Mexico City. ( 28401101 )
2017
43
Hemolytic anemia with null PKLR mutations identified using whole exome sequencing and cured by hematopoietic stem cell transplantation combined with splenectomy. ( 27595284 )
2016
44
ATP11C is a major flippase in human erythrocytes and its defect causes congenital hemolytic anemia. ( 26944472 )
2016
45
Warm antibody hemolytic anemia-a rare presentation of neonatal lupus. ( 27516434 )
2016
46
Clinical characteristics and long-term outcomes of warm-type autoimmune hemolytic anemia. ( 27077773 )
2016
47
Band 3 null(VIENNA) , a novel homozygous SLC4A1 p.Ser477X variant causing severe hemolytic anemia, dyserythropoiesis and complete distal renal tubular acidosis. ( 27718309 )
2016
48
Oral cyclophosphamide was effective for Coombs-negative autoimmune hemolytic anemia in CD16+CD56- chronic lymphoproliferative disorder of NK-cells. ( 28028749 )
2016
49
Gene disruption of dematin causes precipitous loss of erythrocyte membrane stability and severe hemolytic anemia. ( 27073223 )
2016
50
Usefulness of three-dimensional transesophageal echocardiography for diagnosis of hemolytic anemia due to inverted internal felt strip after surgery for aortic dissection. ( 27858229 )
2016

Variations for Hemolytic Anemia

ClinVar genetic disease variations for Hemolytic Anemia:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 HBB NM_000518.4(HBB): c.127T> C (p.Phe43Leu) single nucleotide variant Pathogenic rs33924146 GRCh38 Chromosome 11, 5226765: 5226765
2 HBB NM_000518.4(HBB): c.127T> G (p.Phe43Val) single nucleotide variant Pathogenic rs33924146 GRCh37 Chromosome 11, 5247995: 5247995

Expression for Hemolytic Anemia

Search GEO for disease gene expression data for Hemolytic Anemia.

Pathways for Hemolytic Anemia

Pathways related to Hemolytic Anemia according to GeneCards Suite gene sharing:

(show all 13)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.83 AK1 ALDOA G6PD GCLC GPI GSS
2
Show member pathways
12.63 ALDOA G6PD GPI HK1 PGK1 PKLR
3
Show member pathways
12.41 ALDOA GPI HK1 PGK1 PKLR
4 12.29 ALDOA G6PD HBB HK1
5
Show member pathways
11.75 ALDOA G6PD GPI HK1 PGK1 PKLR
6 11.68 ALDOA HK1 PGK1
7
Show member pathways
11.68 ALDOA HK1 PGK1 PKLR
8 11.47 ALDOA HK1 PGK1
9
Show member pathways
11.43 ALDOA G6PD GPI
10
Show member pathways
11.1 HBA2 HBB RHAG SLC4A1
11 10.61 PGK1 PKLR
12
Show member pathways
10.29 G6PD GPI HK1
13 10.13 G6PD GPI HK1 PGK1

GO Terms for Hemolytic Anemia

Cellular components related to Hemolytic Anemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.7 AK1 ALDOA CD59 G6PD GPI GSS
2 ficolin-1-rich granule lumen GO:1904813 9.58 ALDOA GPI HBB
3 cytosol GO:0005829 9.47 AK1 ALDOA ANK1 G6PD GCLC GPI
4 endocytic vesicle lumen GO:0071682 9.37 HBA2 HBB
5 hemoglobin complex GO:0005833 9.32 HBA2 HBB
6 spectrin-associated cytoskeleton GO:0014731 9.26 ANK1 SPTB
7 haptoglobin-hemoglobin complex GO:0031838 9.16 HBA2 HBB

Biological processes related to Hemolytic Anemia according to GeneCards Suite gene sharing:

(show all 14)
id Name GO ID Score Top Affiliating Genes
1 carbohydrate metabolic process GO:0005975 9.78 G6PD GPI HK1 PKLR
2 hydrogen peroxide catabolic process GO:0042744 9.54 HBA2 HBB
3 gluconeogenesis GO:0006094 9.54 ALDOA GPI PGK1
4 regulation of blood vessel size GO:0050880 9.52 GCLC HBB
5 glutathione biosynthetic process GO:0006750 9.51 GCLC GSS
6 response to cadmium ion GO:0046686 9.5 GCLC GPI GSS
7 oxygen transport GO:0015671 9.49 HBA2 HBB
8 erythrocyte maturation GO:0043249 9.46 EPB42 G6PD
9 bicarbonate transport GO:0015701 9.46 HBA2 HBB RHAG SLC4A1
10 response to xenobiotic stimulus GO:0009410 9.43 GCLC GSS
11 glucose 6-phosphate metabolic process GO:0051156 9.43 G6PD GPI HK1
12 cellular ion homeostasis GO:0006873 9.4 RHAG SLC4A1
13 glycolytic process GO:0006096 9.35 ALDOA GPI HK1 PGK1 PKLR
14 canonical glycolysis GO:0061621 9.02 ALDOA GPI HK1 PGK1 PKLR

Molecular functions related to Hemolytic Anemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 ATP binding GO:0005524 9.95 AK1 EPB42 GCLC GSS HK1 PGK1
2 structural constituent of cytoskeleton GO:0005200 9.54 ANK1 EPB42 SPTB
3 magnesium ion binding GO:0000287 9.46 GCLC GSS NT5C3A PKLR
4 oxygen transporter activity GO:0005344 9.32 HBA2 HBB
5 glucose binding GO:0005536 9.26 G6PD HK1
6 haptoglobin binding GO:0031720 8.96 HBA2 HBB
7 ankyrin binding GO:0030506 8.8 RHAG SLC4A1 SPTB

Sources for Hemolytic Anemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
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42 MeSH
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59 PubMed
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67 TGDB
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