MCID: HML002
MIFTS: 68

Hemolytic Anemia malady

Blood diseases, Immune diseases categories

Summaries for Hemolytic Anemia

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Hemolytic anemia is a form of anemia due to hemolysis, the abnormal breakdown of red blood cells (RBCs),... more...

MalaCards: Hemolytic Anemia, also known as anemia hemolytic, is related to autoimmune hemolytic anemia and deficiency anemia. An important gene associated with Hemolytic Anemia is G6PD (glucose-6-phosphate dehydrogenase), and among its related pathways are Metabolism and MPS IIIC - Sanfilippo syndrome C. The drugs vitamin e and tocopherol acetate and the compounds glyceraldehyde 3-phosphate and lactate have been mentioned in the context of this disorder. Affiliated tissues include testes, liver and b cells, and related mouse phenotypes are hematopoietic system and homeostasis/metabolism.

Description from OMIM:46 612631,266120

Aliases & Classifications for Hemolytic Anemia

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8Disease Ontology, 10DISEASES, 30LifeMap Discovery™, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 46OMIM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Blood diseases, Immune diseases


Aliases & Descriptions:

hemolytic anemia 8 10 30
anemia hemolytic 8 44
hemolytic anemias nos 8
hemolytic anemias 8
anemia, hemolytic 60


External Ids:

Disease Ontology8 DOID:583
MeSH34 D000743
NCIt39 C34376
ICD1025 D55-D59

Related Diseases for Hemolytic Anemia

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Hemolytic Anemia family:

Autoimmune Hemolytic Anemia Congenital Hemolytic Anemia
Hemolytic Anemia Due to Band 3 Montefiore Hemolytic Anemia Due to Erythrocyte Adenosine Deaminase Overproduction

Diseases related to Hemolytic Anemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 330)
idRelated DiseaseScoreTop Affiliating Genes
1autoimmune hemolytic anemia32.0CD59, G6PD
2deficiency anemia31.5SPTA1, SPTB, SLC4A1, GPI, HK1, CD59
3congenital hemolytic anemia31.5G6PD, PKLR, GPI, SPTB
4congenital nonspherocytic hemolytic anemia31.2GPI, PKLR, G6PD
5hereditary spherocytosis30.8G6PD, EPB42, SLC4A1, SPTB, SPTA1
6systemic lupus erythematosus30.7ADA, CFI, GPI, CD59
7pyruvate kinase deficiency30.6G6PD, PKLR
8glucosephosphate dehydrogenase deficiency30.5PKLR, G6PD
9hereditary elliptocytosis30.5SPTA1, SPTB, SLC4A1, G6PD
10malaria30.5G6PD, STOM, SLC4A1
11tuberculosis30.5GPI, ADA
12adenocarcinoma30.3GCLM, CD59, GPI, ADA
13pyropoikilocytosis30.2SPTA1
14diabetes mellitus30.2HK1, PKLR, G6PD
15sickle cell anemia30.2SPTB
16alpha thalassemia29.9G6PD, SLC4A1, SPTB
17sickle cell disease29.9CFI, G6PD
18chronic myeloid leukemia29.9ADA, ALDOA, CD59, G6PD
19leishmaniasis29.9GPI
20myeloid leukemia29.9GPI, CFI
21paroxysmal nocturnal hemoglobinuria29.9CD59, G6PD
22leukemia10.8
23hepatitis10.8
24autoimmune hepatitis10.8
25thrombocytopenia10.8
26chronic lymphocytic leukemia10.7
27purpura10.6
28hepatitis c10.6
29hepatitis a10.6
30pure red-cell aplasia10.6
31autoimmune thrombocytopenic purpura10.5
32warm antibody hemolytic anemia10.5
33lupus erythematosus10.5
34methemoglobinemia10.5
35primary biliary cirrhosis10.5
36neonatal anemia10.5
37acute leukemia10.4
38antiphospholipid syndrome10.4
39evans' syndrome10.4
40iron deficiency anemia10.4
41hodgkin's lymphoma10.4
42hypertension10.4
43favism10.4
44common variable immunodeficiency10.4
45thrombotic thrombocytopenic purpura10.4
46ulcerative colitis10.4
47glomerulonephritis10.4
48pneumonia10.4
49nonspherocytic hemolytic anemia due to hexokinase deficiency10.4
50hemoglobinuria10.3

Graphical network of the top 20 diseases related to Hemolytic Anemia:



Diseases related to hemolytic anemia

Clinical Features for Hemolytic Anemia

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Sources:
46OMIM
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Clinical features from OMIM:

612631,266120

Drugs & Therapeutics for Hemolytic Anemia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Hemolytic Anemia

Drug clinical trials:

Search ClinicalTrials for Hemolytic Anemia

Search NIH Clinical Center for Hemolytic Anemia

Search CenterWatch for Hemolytic Anemia

Inferred drug relations via UMLS60/NDF-RT40:

Show with subtypes

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Hemolytic Anemia cell therapies at LifeMap Discovery.

Genetic Tests for Hemolytic Anemia

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Anatomical Context for Hemolytic Anemia

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32MalaCards
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MalaCards organs/tissues related to Hemolytic Anemia:

32
Testes, Liver, B cells, T cells, Bone, Kidney, Bone marrow, Lung, Spleen, Heart, Myeloid, Thyroid, Endothelial, Monocytes, Cervix, Pancreas, Colon, Breast, Ovary, Spinal cord, Brain, Nk cells

Animal Models for Hemolytic Anemia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Hemolytic Anemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539710.9ADA, GCLC, G6PD, STOM, RHAG, PRDX2
2MP:000537610.8PKLR, PRDX2, RHAG, AK1, G6PD, GCLM
3MP:000538710.7GCLC, PRDX2, PKLR, HK1, EPB42, GPI
4MP:001076810.7GCLM, G6PD, PKLR, CD59, GPI, SLC4A1
5MP:000536710.6CD59, HK1, CFI, SLC4A1, SPTB, SPTA1
6MP:000537010.5GCLC, HK1, GPI, SPTB, SPTA1, ADA
7MP:000538410.3GCLC, GCLM, G6PD, AK1, PRDX2, CD59

Publications for Hemolytic Anemia

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50PubMed
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Articles related to Hemolytic Anemia:

(show top 50)    (show all 1214)
idTitleAuthorsYear
1
Thrombotic thrombocytopenic purpura and other thrombotic microangiopathic hemolytic anemias: Diagnosis and classification. (24418304)
2014
2
Pure red cell aplasia following autoimmune hemolytic anemia: an enigma. (23525059)
2013
3
Published reports of delayed hemolytic anemia after treatment with artesunate for severe malaria--worldwide, 2010-2012. (23302816)
2013
4
Sirolimus as Maintenance Treatment in an Infant with Life-threatening Multiresistant Pure Red Cell Anemia/Autoimmune Hemolytic Anemia. (23588343)
2013
5
Demyelinating neuropathy and autoimmune hemolytic anemia in a patient with pancreatic cancer. (23903509)
2013
6
Images in clinical medicine. Hemolytic anemia after mitral-valve repair. (23150979)
2012
7
Hemolytic anemia accelerated by Babesia spp. infection in splenectomized patient. (23330507)
2012
8
False-positive human immunodeficiency virus antibody test and autoimmune hemolytic anemia in a patient with angioimmunoblastic T-cell lymphoma. (22001471)
2011
9
Enzymatic and metabolic characterization of the phosphoglycerate kinase deficiency associated with chronic hemolytic anemia caused by the PGK-Barcelona mutation. (21269848)
2011
10
A case of primary ovarian lymphoma with autoimmune hemolytic anemia achieving complete response with Rituximab-based combination chemotherapy. (22563154)
2011
11
Severe refractory autoimmune hemolytic anemia with both warm and cold autoantibodies that responded completely to a single cycle of rituximab: a case report. (21504611)
2011
12
Evaluating treatment of hepatitis C for hemolytic anemia management. (20303990)
2010
13
Hemolytic anemia after eculizumab in paroxysmal nocturnal hemoglobinuria. (20818912)
2010
14
Efficacy of rituximab in autoimmune hemolytic anemia associated with splenic marginal zone lymphoma. (19578848)
2010
15
Immune hemolytic anemia--selected topics. (20008185)
2009
16
G6PD deficiency, absence of alpha-thalassemia, and hemolytic rate at baseline are significant independent risk factors for abnormally high cerebral velocities in patients with sickle cell anemia. (18772456)
2008
17
Autoimmune hemolytic anemia. (18537006)
2008
18
A novel G6PD mutation leading to chronic hemolytic anemia. (18677765)
2008
19
Hemolytic anemia after operation for aortic dissection using teflon felt strips. (18442587)
2008
20
Hemolytic anemia due to warm autoantibodies. (17904259)
2008
21
Severe autoimmune hemolytic anemia after unrelated umbilical cord blood transplant for familial hemophagocytic lymphohistiocytosis: significant improvement after treatment with rituximab. (17279011)
2007
22
An update on drug-induced immune hemolytic anemia. (18284300)
2007
23
Transgenic rescue of hemolytic anemia due to red blood cell pyruvate kinase deficiency. (17550844)
2007
24
A patient with mixed connective tissue disease and mixed-type autoimmune hemolytic anemia. (16271090)
2005
25
Glucose-6-phosphate dehydrogenase deficiency in two returning Operation Iraqi Freedom soldiers who developed hemolytic anemia while receiving primaquine prophylaxis for malaria. (15916292)
2005
26
Successful treatment with cyclosporine and high-dose gamma immunoglobulin for persistent parvovirus B19 infection in a patient with refractory autoimmune hemolytic anemia. (15540900)
2004
27
Autoimmune hemolytic anemia occurred prior to evident nephropathy in a patient with chronic hepatitis C virus infection: case report. (12946280)
2003
28
Intracaval and intracardiac metastatic nonseminomatous germ cell tumor: a rare cause of hemolytic anemia and thrombocytopenia. (12449733)
2002
29
Hemolytic anemia after methylene blue therapy for aniline-induced methemoglobinemia. (11824767)
2002
30
Autoimmune hemolytic anemia (AIHA) in an infant rhesus macaque (Macaca mulatta). (10950457)
2000
31
Erythroid phosphatidyl serine exposure is not predictive of thrombotic risk in mice with hemolytic anemia. (10772878)
2000
32
A missense mutation in the heavy subunit of gamma-glutamylcysteine synthetase gene causes hemolytic anemia. (10733484)
2000
33
Spontaneous regression of chronic lymphocytic leukemia and simultaneous development of autoimmune hemolytic anemia and autoimmune thrombocytopenia. (10936875)
2000
34
Application of the gel test using and anti-IgA antiglobulin for the immunologic diagnosis of autoimmune hemolytic anemia with a negative direct Coombs test]. (10472686)
1999
35
Case of direct Coombs-test-positive hemolytic anemia with bleeding tendency due to prominent low activity of factor V]. (9019517)
1996
36
Autoimmune hemolytic anemia in allergic granulomatous angitis (Churg-Strauss syndrome). (8867725)
1996
37
Molecular study of pyruvate kinase deficient patients with hereditary nonspherocytic hemolytic anemia. (7706479)
1995
38
Clonality of cold agglutinins in patients with hemolytic anemia: an analysis by high-resolution two-dimensional gel electrophoresis. (1609770)
1992
39
Characterization of autoantibodies in mixed-type autoimmune hemolytic anemia. (1905082)
1991
40
Cold agglutinin hemolytic anemia in a patient with adult-onset Still's disease. (2097264)
1990
41
Adenosine deaminase (ADA) overproduction associated with congenital hemolytic anemia: case report and molecular analysis. (3164080)
1988
42
Hemolytic anemia, splenic abscess, and pleural effusion caused by Salmonella typhi. (7462704)
1980
43
Hemolytic anemia following valvuloplastic surgery for congenital mitral regurgitation : report of two cases. (749734)
1978
44
T cell deficiency in patients with autoimmune hemolytic anemia ('warm type'). (1084624)
1976
45
Membrane-localized pyruvate kinase of red blood cells in hemolytic anemia associated with pyruvate kinase deficiency. (1206967)
1975
46
Autoimmune hemolytic anemia with hemoglobinemia and hemoglobinuria in the absence of a demonstrable hemolysin or complement-binding antibody. (5766098)
1969
47
Hereditary elliptocytosis with hemolytic anemia complicating pregnancy. (5660991)
1968
48
Malignant nephrosclerosis in women post partum. A note on microangiopathic hemolytic anemia. (5006762)
1967
49
AUTOIMMUNE HEMOLYTIC ANEMIA WITH TERMINAL LYMPHOMA AND CYTOMEGALIC INCLUSION DISEASE. (14144143)
1964
50
Exchange transfusion in a neonatal crisis of congenital hemolytic anemia. (14434017)
1960

Genetic Variations for Hemolytic Anemia

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Expression for genes affiliated with Hemolytic Anemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hemolytic Anemia

Search GEO for disease gene expression data for Hemolytic Anemia.

Pathways for genes affiliated with Hemolytic Anemia

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Sources:
53Reactome, 29KEGG, 12EMD Millipore, 37NCBI BioSystems Database, 49PharmGKB
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Compounds for genes affiliated with Hemolytic Anemia

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44Novoseek, 28IUPHAR, 24HMDB, 11DrugBank, 49PharmGKB
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Compounds related to Hemolytic Anemia according to GeneCards/GeneDecks:

(show all 25)
idCompoundScoreTop Affiliating Genes
1glyceraldehyde 3-phosphate4411.0ALDOA, G6PD, AK1, PRDX2, PKLR, GPI
2lactate4411.0G6PD, AK1, CD59, HK1, GPI, SLC4A1
3pyruvate4411.0BPGM, G6PD, AK1, PKLR, HK1, GPI
4atp44 2812.0G6PD, AK1, PRDX2, PKLR, CD59, HK1
5creatinine4411.0G6PD, AK1, PRDX2, HK1, GPI, CFI
6glucose4411.0STOM, AK1, CD59, GPI, CFI, SLC4A1
7lipid4410.9G6PD, STOM, RHAG, CD59, GPI, CFI
86-phosphogluconate4410.9G6PD, AK1, GPI, ADA
9oxygen44 2411.9GCLC, PRDX2, CD59, HK1, SPTB
10fructose-1,6-bisphosphate4410.9G6PD, GPI, ALDOA
11serine4410.8G6PD, STOM, PRDX2, PKLR, HK1, GPI
12cellulose acetate4410.8ADA, GPI, G6PD
13isocitrate4410.8G6PD, PRDX2, GPI
14ddamp4410.8ADA, AK1
15Alpha-D-Glucose-6-Phosphate1110.8GPI, HK1
16sucrose44 11 2412.8CD59, HK1, GPI, CFI
17adenylate4410.8G6PD, AK1, GPI, ALDOA, ADA
18alpha-ketoglutarate4410.7GPI, PKLR, G6PD
19diethylmaleate4410.7GCLM, GCLC
2023-diphosphoglycerate4410.6BPGM, G6PD
214-hydroxynonenal44 2411.6GCLM, GCLC
22glucose 6-phosphate44 2411.5GPI, HK1, G6PD
23sulfamethoxazole44 49 1112.5G6PD, GCLC
24mefloquine44 1111.4G6PD, STOM
25glycogen44 2411.3ALDOA, GPI, HK1, PKLR

GO Terms for genes affiliated with Hemolytic Anemia

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16Gene Ontology
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Cellular components related to Hemolytic Anemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:00582910.8ADA, GCLC, GCLM, G6PD, AK1, PRDX2
2glutamate-cysteine ligase complexGO:01710910.5GCLC, GCLM
3intrinsic to internal side of plasma membraneGO:03123510.5SPTA1, SPTB
4spectrin-associated cytoskeletonGO:01473110.4SPTA1, SPTB
5spectrinGO:00809110.2SPTA1, SPTB

Biological processes related to Hemolytic Anemia according to GeneCards/GeneDecks:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1small molecule metabolic processGO:04428111.0AK1, G6PD, GCLM, GCLC, RHAG, PKLR
2carbohydrate metabolic processGO:00597510.9ALDOA, GPI, HK1, PKLR, G6PD, BPGM
3glycolysisGO:00609610.9ALDOA, GPI, HK1, PKLR, BPGM
4glucose 6-phosphate metabolic processGO:05115610.9G6PD, HK1, GPI
5negative regulation of neuron apoptotic processGO:04352410.9GCLC, GCLM, PRDX2, GPI
6regulation of mitochondrial depolarizationGO:05190010.8GCLM, GCLC
7response to nitrosative stressGO:05140910.8GCLC, GCLM
8cysteine metabolic processGO:00653410.8GCLM, GCLC
9cellular ion homeostasisGO:00687310.8SLC4A1, RHAG
10porphyrin-containing compound biosynthetic processGO:00677910.8SPTA1, SPTB
11plasma membrane organizationGO:00700910.7SPTB, SPTA1
12glutamate metabolic processGO:00653610.7GCLM, GCLC
13response to oxidative stressGO:00697910.7PRDX2, GCLM, GCLC
14erythrocyte maturationGO:04324910.7EPB42, G6PD
15regulation of blood vessel sizeGO:05088010.7GCLC, GCLM
16glucose metabolic processGO:00600610.6ALDOA, GPI, PKLR
17regulation of cell shapeGO:00836010.6ALDOA, SPTA1, EPB42
18ATP biosynthetic processGO:00675410.5ALDOA, PKLR
19actin filament cappingGO:05169310.5SPTB, SPTA1
20glutathione biosynthetic processGO:00675010.4GCLC, GCLM
21cellular response to oxidative stressGO:03459910.2PRDX2, G6PD

Molecular functions related to Hemolytic Anemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein heterodimerization activityGO:04698210.5SPTA1, SPTB, GCLM, GCLC
2ankyrin bindingGO:03050610.5SPTB, SLC4A1, RHAG
3glutamate-cysteine ligase activityGO:00435710.4GCLM, GCLC
4structural constituent of cytoskeletonGO:00520010.2EPB42, SPTB, SPTA1

Products for genes affiliated with Hemolytic Anemia

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  • Antibodies
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  • Lysates
  • Antibodies

Sources for Hemolytic Anemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet