MCID: HML002
MIFTS: 68

Hemolytic Anemia malady

Blood diseases, Immune diseases categories

Summaries for Hemolytic Anemia

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Hemolytic anemia is a form of anemia due to hemolysis, the abnormal breakdown of red blood cells (RBCs),... more...

MalaCards: Hemolytic Anemia, also known as anemia hemolytic, is related to autoimmune hemolytic anemia and deficiency anemia. An important gene associated with Hemolytic Anemia is G6PD (glucose-6-phosphate dehydrogenase), and among its related pathways are Metabolism and MPS IIIC - Sanfilippo syndrome C. The drugs vitamin e and tocopherol acetate and the compounds glyceraldehyde 3-phosphate and lactate have been mentioned in the context of this disorder. Affiliated tissues include testes, liver and b cells, and related mouse phenotypes are hematopoietic system and homeostasis/metabolism.

Description from OMIM:46 612631,266120

Aliases & Classifications for Hemolytic Anemia

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8Disease Ontology, 10DISEASES, 30LifeMap Discovery™, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 46OMIM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Blood diseases, Immune diseases


Aliases & Descriptions:

hemolytic anemia 8 10 30
anemia hemolytic 8 44
hemolytic anemias nos 8
hemolytic anemias 8
anemia, hemolytic 60


External Ids:

Disease Ontology8 DOID:583
MeSH34 D000743
NCIt39 C34376
ICD1025 D55-D59

Related Diseases for Hemolytic Anemia

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17GeneCards, 18GeneDecks
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Diseases in the Hemolytic Anemia family:

Autoimmune Hemolytic Anemia Congenital Hemolytic Anemia
Hemolytic Anemia Due to Band 3 Montefiore Hemolytic Anemia Due to Erythrocyte Adenosine Deaminase Overproduction

Diseases related to Hemolytic Anemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 330)
idRelated DiseaseScoreTop Affiliating Genes
1autoimmune hemolytic anemia32.0CD59, G6PD
2deficiency anemia31.5SPTA1, SPTB, SLC4A1, GPI, HK1, CD59
3congenital hemolytic anemia31.5G6PD, PKLR, GPI, SPTB
4congenital nonspherocytic hemolytic anemia31.2GPI, PKLR, G6PD
5hereditary spherocytosis30.8G6PD, EPB42, SLC4A1, SPTB, SPTA1
6systemic lupus erythematosus30.7ADA, CFI, GPI, CD59
7pyruvate kinase deficiency30.6G6PD, PKLR
8glucosephosphate dehydrogenase deficiency30.5PKLR, G6PD
9hereditary elliptocytosis30.5SPTA1, SPTB, SLC4A1, G6PD
10malaria30.5G6PD, STOM, SLC4A1
11tuberculosis30.5GPI, ADA
12adenocarcinoma30.3GCLM, CD59, GPI, ADA
13pyropoikilocytosis30.2SPTA1
14diabetes mellitus30.2HK1, PKLR, G6PD
15sickle cell anemia30.2SPTB
16alpha thalassemia29.9G6PD, SLC4A1, SPTB
17sickle cell disease29.9CFI, G6PD
18chronic myeloid leukemia29.9ADA, ALDOA, CD59, G6PD
19leishmaniasis29.9GPI
20myeloid leukemia29.9GPI, CFI
21paroxysmal nocturnal hemoglobinuria29.9CD59, G6PD
22leukemia10.8
23hepatitis10.8
24autoimmune hepatitis10.8
25thrombocytopenia10.8
26chronic lymphocytic leukemia10.7
27purpura10.6
28hepatitis c10.6
29hepatitis a10.6
30pure red-cell aplasia10.6
31autoimmune thrombocytopenic purpura10.5
32warm antibody hemolytic anemia10.5
33lupus erythematosus10.5
34methemoglobinemia10.5
35primary biliary cirrhosis10.5
36neonatal anemia10.5
37acute leukemia10.4
38antiphospholipid syndrome10.4
39evans' syndrome10.4
40iron deficiency anemia10.4
41hodgkin's lymphoma10.4
42hypertension10.4
43favism10.4
44common variable immunodeficiency10.4
45thrombotic thrombocytopenic purpura10.4
46ulcerative colitis10.4
47glomerulonephritis10.4
48pneumonia10.4
49nonspherocytic hemolytic anemia due to hexokinase deficiency10.4
50hemoglobinuria10.3

Graphical network of the top 20 diseases related to Hemolytic Anemia:



Diseases related to hemolytic anemia

Clinical Features for Hemolytic Anemia

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Sources:
46OMIM
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Clinical features from OMIM:

612631,266120

Drugs & Therapeutics for Hemolytic Anemia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Hemolytic Anemia

Drug clinical trials:

Search ClinicalTrials for Hemolytic Anemia

Search NIH Clinical Center for Hemolytic Anemia

Search CenterWatch for Hemolytic Anemia

Inferred drug relations via UMLS60/NDF-RT40:

Show with subtypes

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Hemolytic Anemia cell therapies at LifeMap Discovery.

Genetic Tests for Hemolytic Anemia

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Anatomical Context for Hemolytic Anemia

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32MalaCards
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MalaCards organs/tissues related to Hemolytic Anemia:

32
Testes, Liver, B cells, T cells, Bone, Kidney, Bone marrow, Spleen, Lung, Heart, Myeloid, Thyroid, Endothelial, Monocytes, Pancreas, Cervix, Colon, Ovary, Nk cells, Spinal cord, Brain, Breast

Animal Models for Hemolytic Anemia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Hemolytic Anemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539710.9ADA, GCLC, G6PD, STOM, RHAG, PRDX2
2MP:000537610.8PKLR, PRDX2, RHAG, AK1, G6PD, GCLM
3MP:000538710.7GCLC, PRDX2, PKLR, HK1, EPB42, GPI
4MP:001076810.7GCLM, G6PD, PKLR, CD59, GPI, SLC4A1
5MP:000536710.6CD59, HK1, CFI, SLC4A1, SPTB, SPTA1
6MP:000537010.5GCLC, HK1, GPI, SPTB, SPTA1, ADA
7MP:000538410.3GCLC, GCLM, G6PD, AK1, PRDX2, CD59

Publications for Hemolytic Anemia

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50PubMed
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Articles related to Hemolytic Anemia:

(show top 50)    (show all 1214)
idTitleAuthorsYear
1
The first example of a patient with etoricoxib-induced immune hemolytic anemia. (22882551)
2013
2
What caused hemolytic anemia and colicky abdominal pain? Lead! (23864812)
2013
3
Autoimmune hemolytic anemia with concurrent acute parvovirus b19 infection in a heterozygous for sickle cell patient and literature review. (23758143)
2013
4
Erythropoietin May Improve Anemia in Patients with Autoimmune Hemolytic Anemia Associated with Reticulocytopenia. (22851939)
2012
5
IgA variant of anti-glomerular basement membrane glomerulonephritis associated with pulmonary hemorrhage and microangiopathic hemolytic anemia. (22401499)
2012
6
Autoimmune hemolytic anemia and classical Hodgkin lymphoma: a case report and literature review. (22706493)
2012
7
Change and significance of Th17 cells and its secretive IL-17 in patients with autoimmune hemolytic anemia]. (21651870)
2011
8
Severe immune hemolytic anemia due to pemetrexed in a patient with non-small cell lung cancer. (21997597)
2011
9
Schistocytic hemolytic anemia owing to central venous catheter in a child with acute lymphoblastic leukemia. (20505536)
2010
10
Attempts to support an immune etiology in 800 patients with direct antiglobulin test-negative hemolytic anemia. (22356452)
2010
11
Severe non-valve-related hemolytic anemia following aortic root replacement. (20884735)
2010
12
Autoimmune hemolytic anemia as a paraneoplastic phenomenon in solid tumors: A critical analysis of 52 cases reported in the literature. (20503022)
2010
13
Successful treatment of IgM-mediated autoimmune hemolytic anemia with bortezomib. (20110437)
2010
14
Retinal phlebitis associated with autoimmune hemolytic anemia. (20001258)
2009
15
Immune hemolytic anemia after treatment with pemetrexed for lung cancer. (18303446)
2008
16
Differential contribution of three activating IgG Fc receptors (FcgammaRI, FcgammaRIII, and FcgammaRIV) to IgG2a- and IgG2b-induced autoimmune hemolytic anemia in mice. (18209093)
2008
17
Fatal hemolytic anemia associated with metformin: a case report. (18783609)
2008
18
Severe neurologic complication after delayed hemolytic transfusion reaction in 2 children with sickle cell anemia: significant diagnosis and therapeutic challenges. (19131783)
2008
19
Erythrocyte adenylate kinase deficiency: characterization of recombinant mutant forms and relationship with nonspherocytic hemolytic anemia. (17662886)
2007
20
Primary diffuse large B-cell lymphoma of the bone marrow complicated with autoimmune hemolytic anemia and erythroid hypoplasia]. (17695307)
2007
21
Autoimmune hemolytic anemia caused by cold agglutinins in a young pregnant woman. (16854701)
2006
22
Autoimmune hemolytic anemia associated with benign ovarian cyst: a case report and review of literature. (14646159)
2003
23
Clinically significant autoimmune hemolytic anemia with a negative direct antiglobulin test by routine tube test and positive by column agglutination method. (15373547)
2002
24
Resolution of severe Donath-Landsteiner autoimmune hemolytic anemia temporally associated with institution of plasmapheresis. (11940774)
2002
25
Rituximab for refractory childhood autoimmune hemolytic anemia. (12489491)
2002
26
Usefulness of methemoglobin/haptoglobin analysis in the follow-up of severe immune hemolytic anemia. (12006477)
2002
27
Autoimmune hemolytic anemia during alpha-interferon treatment in a patient with chronic myelogenous leukemia. (11684283)
2001
28
Glucose-6-phosphate dehydrogenase deficiency and hereditary hemolytic anemia]. (10645652)
1999
29
High-dose intravenous immunoglobulin as single therapy in a child with autoimmune hemolytic anemia. (9267883)
1997
30
Hemolytic anemias due to erythrocyte enzyme deficiencies. (8813716)
1996
31
Study of the molecular defects in glucose phosphate isomerase- deficient patients affected by chronic hemolytic anemia. (8822952)
1996
32
Treatment of hemolytic anemia due to red blood cell fragmentation using recombinant human erythropoietin. (7609253)
1995
33
Hexokinase mutations that produce nonspherocytic hemolytic anemia. (7655856)
1995
34
Clinical features and splenic pathologic changes in patients with autoimmune hemolytic anemia and congenital hemolytic anemia. (8331977)
1993
35
Hypophosphatemia and hemolytic anemia associated with diabetes mellitus and hepatic lipidosis in cats. (8263844)
1993
36
Band 3 Tuscaloosa: Pro-327-->Arg substitution in the cytoplasmic domain of erythrocyte band 3 protein associated with spherocytic hemolytic anemia and partial deficiency of protein 4.2. (1378323)
1992
37
Acquired von Willebrand syndrome with autoimmune hemolytic anemia]. (2246822)
1990
38
Erythrocyte pyruvate kinase deficiency. A case of severe congenital hemolytic anemia. (2761512)
1989
39
Pernicious anemia, Hashimoto's thyroiditis and SjAPgren's in a woman with SLE and autoimmune hemolytic anemia. (2746580)
1989
40
Pulmonary embolism and hemolytic anemia in a patient with cold agglutinin disease. (7300009)
1981
41
The first stable variant of erythrocyte glucose-phosphate isomerase associated with severe hemolytic anemia. (7435496)
1980
42
Abnormal red cell membrane phosphatase activity in an unidentified congenital hemolytic anemia. (224968)
1979
43
Acquired hemolytic anemia associated with infectious mononucleosis in a patient with congenital pyruvate kinase deficiency. (4686857)
1973
44
Malignant hypertension, uremia and hemolytic anemia in a patient on oral contraceptives. (5083217)
1972
45
Nonspherocytic congenital hemolytic anemia due to a new G-6-pd variant: g-6-pd alhambra. (5413384)
1970
46
Skull changes in iron deficiency anemia simulating congenital hemolytic anemia. (13689105)
1961
47
Renal hemosiderosis in the hemolytic anemias: diagnosis by means of needle biopsy. (14415802)
1960
48
Metabolic abnormalities of erythrocytes from patients with congenital nonspherocytic hemolytic anemia. (13847572)
1959
49
Splenectomy for pure red-cell hypoplastic (aregenerative) anemia associated with autoimmune hemolytic disease; report of a case. (13214388)
1954
50
Congenital hemolytic anemia; a case requiring early splenectomy. (20280332)
1946

Genetic Variations for Hemolytic Anemia

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Expression for genes affiliated with Hemolytic Anemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hemolytic Anemia

Search GEO for disease gene expression data for Hemolytic Anemia.

Pathways for genes affiliated with Hemolytic Anemia

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Sources:
53Reactome, 29KEGG, 12EMD Millipore, 37NCBI BioSystems Database, 49PharmGKB
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Compounds for genes affiliated with Hemolytic Anemia

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Sources:
44Novoseek, 28IUPHAR, 24HMDB, 11DrugBank, 49PharmGKB
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Compounds related to Hemolytic Anemia according to GeneCards/GeneDecks:

(show all 25)
idCompoundScoreTop Affiliating Genes
1glyceraldehyde 3-phosphate4411.0ALDOA, G6PD, AK1, PRDX2, PKLR, GPI
2lactate4411.0G6PD, AK1, CD59, HK1, GPI, SLC4A1
3pyruvate4411.0BPGM, G6PD, AK1, PKLR, HK1, GPI
4atp44 2812.0G6PD, AK1, PRDX2, PKLR, CD59, HK1
5creatinine4411.0G6PD, AK1, PRDX2, HK1, GPI, CFI
6glucose4411.0STOM, AK1, CD59, GPI, CFI, SLC4A1
7lipid4410.9G6PD, STOM, RHAG, CD59, GPI, CFI
86-phosphogluconate4410.9G6PD, AK1, GPI, ADA
9oxygen44 2411.9GCLC, PRDX2, CD59, HK1, SPTB
10fructose-1,6-bisphosphate4410.9G6PD, GPI, ALDOA
11serine4410.8G6PD, STOM, PRDX2, PKLR, HK1, GPI
12cellulose acetate4410.8ADA, GPI, G6PD
13isocitrate4410.8G6PD, PRDX2, GPI
14ddamp4410.8ADA, AK1
15Alpha-D-Glucose-6-Phosphate1110.8GPI, HK1
16sucrose44 11 2412.8CD59, HK1, GPI, CFI
17adenylate4410.8G6PD, AK1, GPI, ALDOA, ADA
18alpha-ketoglutarate4410.7GPI, PKLR, G6PD
19diethylmaleate4410.7GCLM, GCLC
2023-diphosphoglycerate4410.6BPGM, G6PD
214-hydroxynonenal44 2411.6GCLM, GCLC
22glucose 6-phosphate44 2411.5GPI, HK1, G6PD
23sulfamethoxazole44 49 1112.5G6PD, GCLC
24mefloquine44 1111.4G6PD, STOM
25glycogen44 2411.3ALDOA, GPI, HK1, PKLR

GO Terms for genes affiliated with Hemolytic Anemia

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16Gene Ontology
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Cellular components related to Hemolytic Anemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:00582910.8ADA, GCLC, GCLM, G6PD, AK1, PRDX2
2glutamate-cysteine ligase complexGO:01710910.5GCLC, GCLM
3intrinsic to internal side of plasma membraneGO:03123510.5SPTA1, SPTB
4spectrin-associated cytoskeletonGO:01473110.4SPTA1, SPTB
5spectrinGO:00809110.2SPTA1, SPTB

Biological processes related to Hemolytic Anemia according to GeneCards/GeneDecks:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1small molecule metabolic processGO:04428111.0AK1, G6PD, GCLM, GCLC, RHAG, PKLR
2carbohydrate metabolic processGO:00597510.9ALDOA, GPI, HK1, PKLR, G6PD, BPGM
3glycolysisGO:00609610.9ALDOA, GPI, HK1, PKLR, BPGM
4glucose 6-phosphate metabolic processGO:05115610.9G6PD, HK1, GPI
5negative regulation of neuron apoptotic processGO:04352410.9GCLC, GCLM, PRDX2, GPI
6regulation of mitochondrial depolarizationGO:05190010.8GCLM, GCLC
7response to nitrosative stressGO:05140910.8GCLC, GCLM
8cysteine metabolic processGO:00653410.8GCLM, GCLC
9cellular ion homeostasisGO:00687310.8SLC4A1, RHAG
10porphyrin-containing compound biosynthetic processGO:00677910.8SPTA1, SPTB
11plasma membrane organizationGO:00700910.7SPTB, SPTA1
12glutamate metabolic processGO:00653610.7GCLM, GCLC
13response to oxidative stressGO:00697910.7PRDX2, GCLM, GCLC
14erythrocyte maturationGO:04324910.7EPB42, G6PD
15regulation of blood vessel sizeGO:05088010.7GCLC, GCLM
16glucose metabolic processGO:00600610.6ALDOA, GPI, PKLR
17regulation of cell shapeGO:00836010.6ALDOA, SPTA1, EPB42
18ATP biosynthetic processGO:00675410.5ALDOA, PKLR
19actin filament cappingGO:05169310.5SPTB, SPTA1
20glutathione biosynthetic processGO:00675010.4GCLC, GCLM
21cellular response to oxidative stressGO:03459910.2PRDX2, G6PD

Molecular functions related to Hemolytic Anemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein heterodimerization activityGO:04698210.5SPTA1, SPTB, GCLM, GCLC
2ankyrin bindingGO:03050610.5SPTB, SLC4A1, RHAG
3glutamate-cysteine ligase activityGO:00435710.4GCLM, GCLC
4structural constituent of cytoskeletonGO:00520010.2EPB42, SPTB, SPTA1

Products for genes affiliated with Hemolytic Anemia

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Sources for Hemolytic Anemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet