MCID: HML002
MIFTS: 66

Hemolytic Anemia malady

Genetic diseases, Blood diseases, Immune diseases, Rare diseases categories
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Summaries for Hemolytic Anemia

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Sources:
65Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:65 Hemolytic anemia is a form of anemia due to hemolysis, the abnormal breakdown of red blood cells (RBCs),... more...

MalaCards: Hemolytic Anemia, also known as anemia hemolytic, is related to autoimmune hemolytic anemia and congenital hemolytic anemia. An important gene associated with Hemolytic Anemia is G6PD (glucose-6-phosphate dehydrogenase), and among its related pathways are Pentose Phosphate Pathway and Glutathione metabolism. The drugs vitamin e and tocopherol acetate and the compounds Beta-D-Glucose 6-phosphate and fructose-1,6-bisphosphate have been mentioned in the context of this disorder. Affiliated tissues include testes, liver and b cells, and related mouse phenotypes are liver/biliary system and immune system.

Description from OMIM:47 266120,612631

Aliases & Classifications for Hemolytic Anemia

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Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 31LifeMap Discovery™, 62UMLS, 47OMIM, 58SNOMED-CT, 40NCIt, 35MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Blood diseases, Immune diseases


Aliases & Descriptions:

hemolytic anemia 8 10 31
anemia hemolytic 8 45
hemolytic anemias nos 8
hemolytic anemias 8
anemia, hemolytic 62


External Ids:

Disease Ontology8 DOID:583
NCIt40 C34376
MeSH35 D000743
ICD1025 D55-D59

Related Diseases for Hemolytic Anemia

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Hemolytic Anemia family:

Autoimmune Hemolytic Anemia Congenital Hemolytic Anemia
Hemolytic Anemia Due to Band 3 Montefiore Hemolytic Anemia Due to Erythrocyte Adenosine Deaminase Overproduction

Diseases related to Hemolytic Anemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 371)
idRelated DiseaseScoreTop Affiliating Genes
1autoimmune hemolytic anemia32.2CD59, G6PD
2congenital hemolytic anemia31.5GPI, G6PD, PKLR
3pyruvate kinase deficiency31.3PKLR, G6PD
4congenital nonspherocytic hemolytic anemia31.3PKLR, G6PD, GPI
5hereditary spherocytosis30.9EPB42, G6PD
6systemic lupus erythematosus30.8GPI, ADA, CD59
7glucosephosphate dehydrogenase deficiency30.7G6PD, PKLR
8malaria30.7G6PD
9hemoglobinuria30.7CD59, G6PD
10hereditary elliptocytosis30.6EPB42
11paroxysmal nocturnal hemoglobinuria30.6G6PD, CD59
12adenocarcinoma30.3GPI, PGK1, ADA, CD59
13aplastic anemia30.3CD59, PGK1
14diabetes mellitus30.2HK1, PKLR, G6PD
15gaucher's disease30.0ADA, PKLR
16chronic myeloid leukemia30.0CD59, ADA, G6PD
17acute lymphocytic leukemia30.0G6PD, ADA, CD59
18deficiency anemia30.0GPI, G6PD, PGK1, PKLR, RHAG, HK1
19breast cancer29.9GPI, G6PD, PGK1, ADA, HK1, CD59
20leukemia10.9
21hepatitis10.9
22chronic lymphocytic leukemia10.8
23thrombocytopenia10.8
24purpura10.6
25hepatitis c10.6
26pure red-cell aplasia10.6
27warm antibody hemolytic anemia10.6
28lupus erythematosus10.5
29methemoglobinemia10.5
30mixed-type autoimmune hemolytic anemia10.5
31primary biliary cirrhosis10.5
32evans' syndrome10.5
33antiphospholipid syndrome10.4
34hypertension10.4
35phosphoglycerate kinase deficiency10.4
36drug-induced autoimmune hemolytic anemia10.4
37ulcerative colitis10.4
38favism10.4
39common variable immunodeficiency10.4
40glomerulonephritis10.4
41hodgkin's lymphoma10.4
42pneumonia10.4
43b-cell lymphomas10.4
44cold agglutinin disease10.4
45glucosephosphate isomerase deficiency10.4
46nonspherocytic hemolytic anemia due to hexokinase deficiency10.4
47hepatitis c virus10.4
48b-cell chronic lymphocytic leukemia10.4
49thrombotic thrombocytopenic purpura10.4
50autoimmune hepatitis10.4

Graphical network of the top 20 diseases related to Hemolytic Anemia:



Diseases related to hemolytic anemia

Symptoms for Hemolytic Anemia

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Sources:
47OMIM
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Clinical features from OMIM:

266120,612631

Drugs & Therapeutics for Hemolytic Anemia

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 62UMLS, 41NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Hemolytic Anemia

Search NIH Clinical Center for Hemolytic Anemia

Inferred drug relations via UMLS62/NDF-RT41:

Show with subtypes

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Hemolytic Anemia cell therapies at LifeMap Discovery.

Genetic Tests for Hemolytic Anemia

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Anatomical Context for Hemolytic Anemia

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Sources:
33MalaCards
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MalaCards organs/tissues related to Hemolytic Anemia:

33
Testes, Liver, B cells, T cells, Bone, Kidney, Bone marrow, Spleen, Lung, Heart, Myeloid, Thyroid, Endothelial, Monocytes, Pancreas, Cervix, Colon, Ovary, Nk cells, Spinal cord, Brain, Breast

Animal Models for Hemolytic Anemia or affiliated genes

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Sources:
37MGI
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MGI Mouse Phenotypes related to Hemolytic Anemia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.7GCLC, HK1, ADA, GPI
2MP:00053877.1GPI, EPB42, ADA, PKLR, HK1, GCLC
3MP:00053976.2GPI, G6PD, EPB42, ADA, PKLR, RHAG
4MP:00053766.0CD59, GPI, G6PD, EPB42, ADA, AK1

Publications for Hemolytic Anemia

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Sources:
52PubMed
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Articles related to Hemolytic Anemia:

(show top 50)    (show all 1180)
idTitleAuthorsYear
1
Thrombotic thrombocytopenic purpura and other thrombotic microangiopathic hemolytic anemias: Diagnosis and classification. (24418304)
2014
2
A mixed-type autoimmune hemolytic anemia with immune thrombocytopenia related with myositis and post-transplantation lymphoproliferative disorder. (24013519)
2013
3
The first example of a patient with etoricoxib-induced immune hemolytic anemia. (22882551)
2013
4
Methemoglobinemia and hemolytic anemia after rasburicase administration in a child with leukemia. (21057874)
2013
5
Autoimmune hemolytic anemia occurred in burn patient: A case report. (24045069)
2013
6
SLE with diffuse alveolar hemorrhage, microangiopathic hemolytic anemia and acute renal failure. (22730045)
2012
7
Splenic infarction, warm autoimmune hemolytic anemia and antiphospholipid antibodies associated with systemic lupus erythematosus. (22623174)
2012
8
Low-dose rituximab in adult patients with idiopathic autoimmune hemolytic anemia: clinical efficacy and biologic studies. (22267606)
2012
9
Incidence of congenital hemolytic anemias in young cholelithiasis patients. (21086564)
2010
10
Trimethoprim-induced immune hemolytic anemia in a pediatric oncology patient presenting as an acute hemolytic transfusion reaction. (20589632)
2010
11
Treatment of immune-mediated hemolytic anemia with individually adjusted heparin dosing in dogs. (20384956)
2010
12
Immune-mediated hemolytic anemia and severe thrombocytopenia in dogs: 12 cases (2001-2008). (20636987)
2010
13
Autoimmune hemolytic anemia as a risk factor of poor outcome in patients with splenic marginal zone lymphoma. (19343544)
2009
14
Cold agglutinin-mediated autoimmune hemolytic anemia in WaldenstrAPm's macroglobulinemia. (19362990)
2009
15
The role of oxidative stress in hemolytic anemia. (18991647)
2008
16
Pulmonary hypertension associated with autoimmune hemolytic anemia: a case report. (16889843)
2007
17
Review: pharmacologic treatment of warm autoimmune hemolytic anemia. (18284301)
2007
18
Severe autoimmune hemolytic anemia after unrelated umbilical cord blood transplant for familial hemophagocytic lymphohistiocytosis: significant improvement after treatment with rituximab. (17279011)
2007
19
Management of cold agglutinin immune hemolytic anemia in pregnancy. (17666637)
2007
20
Autoimmune hemolytic anemia in an elderly patient with primary SjAPgren's syndrome. (16415556)
2005
21
Successful treatment with cyclosporine and high-dose gamma immunoglobulin for persistent parvovirus B19 infection in a patient with refractory autoimmune hemolytic anemia. (15540900)
2004
22
Hemolytic anemia and severe rhabdomyolysis caused by compound heterozygous mutations of the gene for erythrocyte/muscle isozyme of aldolase, ALDOA(Arg303X/Cys338Tyr). (14615364)
2004
23
A case of autoimmune hepatitis and autoimmune hemolytic anemia following hepatitis A infection. (14655068)
2003
24
Sinus histiocytosis with massive lymphadenopathy: complicated by autoimmune hemolytic anemia. (14620195)
2003
25
Autoimmune hemolytic anemia associated with Crohn's disease. (11854607)
2002
26
Myelodysplastic syndrome complicated by autoimmune hemolytic anemia: remission of refractory anemia following mycophenolate mofetil. (12483369)
2002
27
An adolescent with hemolytic anemia and coagulation disorders as manifestation of Wilson's disease, treated with liver transplantation]. (11234295)
2001
28
Severe Coombs'-negative autoimmune hemolytic anemia in a kidney transplant patient. (11799268)
2001
29
Hemolytic anemia after acetaminophen overdose in patient with glucose-6-phosphate dehydrogenase deficiency. (11221636)
2001
30
Eight novel mutations and consequences on mRNA and protein level in pyruvate kinase-deficient patients with nonspherocytic hemolytic anemia. (10679942)
2000
31
Molecular analysis of 29 pyruvate kinase-deficient patients from central Europe with hereditary hemolytic anemia. (9057665)
1997
32
Direct Coombs test-negative autoimmune hemolytic anemia and low-affinity IgG class antibodies. (15387763)
1997
33
Missense mutations in the human glutathione synthetase gene result in severe metabolic acidosis, 5-oxoprolinuria, hemolytic anemia and neurological dysfunction. (9215686)
1997
34
Hemolytic anemia as cause of a marked bilirubin increase in primary biliary cirrhosis]. (8925755)
1996
35
Autoimmune hemolytic anemia in a patient with idiopathic hypereosinophilia. (7639285)
1995
36
High cytokine serum levels in patients with autoimmune hemolytic anemia (AIHA). (7851962)
1994
37
Clinical features and splenic pathologic changes in patients with autoimmune hemolytic anemia and congenital hemolytic anemia. (8331977)
1993
38
Broad beans as a cause of acute hemolytic anemia]. (8519217)
1993
39
Homozygous hereditary elliptocytosis with hemolytic anemia. (6719166)
1984
40
G6PD San Francisco: a new variant of glucose-6-phosphate dehydrogenase associated with congenital nonspherocytic hemolytic anemia. (7353069)
1980
41
Congenital hemolytic anemia associated with dehydrated erythrocytes and increased potassium loss. (4851153)
1974
42
Animal model of human disease. Congenital hemolytic anemia. (4715956)
1973
43
-Glutamyl-cysteine synthetase deficiency. A cause of hereditary hemolytic anemia. (5058793)
1972
44
Functionally abnormal pyruvate kinase in congenital hemolytic anemia. (5388241)
1969
45
Erythrocyte pyruvate kinase deficiency in non-spherocytic hemolytic anemia: a system of multiple genetic markers? (5658389)
1968
46
Microangiopathic hemolytic anemia caused by purpura fulminans. (5653626)
1968
47
Warm antibody hemolytic anemia; prolonged remission despite persistent positive Coombs test. (5310347)
1968
48
A case of congenital hemolytic anemia with hypersplenism. Remission of 24 years following splenectomy and recurrence due to an accessory spleen visualized by thoratrast. (14418071)
1960
49
Renal hemosiderosis in the hemolytic anemias: diagnosis by means of needle biopsy. (14415802)
1960
50
Congenital hemolytic anemia in the Negro. (15432084)
1950

Variations for Hemolytic Anemia

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Expression for genes affiliated with Hemolytic Anemia

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hemolytic Anemia

Search GEO for disease gene expression data for Hemolytic Anemia.

Pathways for genes affiliated with Hemolytic Anemia

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Sources:
50PathCards, 38NCBI BioSystems Database, 55Reactome, 30KEGG, 60Thomson Reuters, 51PharmGKB
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Pathways related to Hemolytic Anemia according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
pentose phosphate pathway (non-oxidative branch)38
pentose phosphate pathway38
PRPP biosynthesis38
9.8G6PD, GPI
2
Show member pathways
glutathione-mediated detoxification I38
glutathione redox reactions I38
glutathione redox reactions II38
4-hydroxy-2-nonenal detoxification38
Glutathione metabolism60
Glutathione metabolism38
9.8GCLC, G6PD
3
Show member pathways
colanic acid building blocks biosynthesis38
N-acetylglucosamine degradation I38
CMP-N-acetylneuraminate biosynthesis I (eukaryotes)38
UDP-D-xylose and UDP-D-glucuronate biosynthesis38
N-acetylglucosamine degradation II38
UDP-N-acetyl-D-glucosamine biosynthesis II38
UDP-N-acetyl-D-galactosamine biosynthesis II38
GDP-L-fucose biosynthesis I (from GDP-D-mannose)38
9.7HK1, GPI
4
Show member pathways
9.6PKLR, HK1
59.5HK1, PGK1
6
Show member pathways
guanosine nucleotides de novo biosynthesis38
guanosine ribonucleotides de novo biosynthesis38
adenosine ribonucleotides de novo biosynthesis38
purine nucleotides de novo biosynthesis38
9.5ADA, AK1
79.5PKLR, PGK1
8
Show member pathways
One Carbon Metabolism38
dTMP de novo biosynthesis (mitochondrial)38
tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate38
Trans-sulfuration and one carbon metabolism38
methionine salvage38
Methionine metabolism60
9.5GCLC, ADA
9
Show member pathways
malate-aspartate shuttle38
glycogen biosynthesis II (from UDP-D-Glucose)38
9.2PKLR, PGK1, GPI
10
Show member pathways
TCA cycle38
pyruvate decarboxylation to acetyl CoA38
NAD phosphorylation and dephosphorylation38
TCA Cycle38
conversion of glucose to acetyl CoA and entry into the TCA cycle38
9.1PGK1, PKLR, HK1
11
Show member pathways
UTP and CTP dephosphorylation II38
ATP ITP metabolism60
purine deoxyribonucleosides salvage38
9.1ADA, AK1, PKLR
12
Show member pathways
glycolysis38
gluconeogenesis38
Glycolysis and Gluconeogenesis38
8.7HK1, PKLR, PGK1, GPI
13
Show member pathways
L-serine degradation38
pentose phosphate pathway (oxidative branch)38
formaldehyde oxidation II (glutathione-dependent)38
8.5GPI, G6PD, PGK1, PKLR, HK1
14
Show member pathways
8.5GPI, G6PD, PGK1, PKLR, HK1
15
Show member pathways
6.6GCLC, GPI, G6PD, PGK1, ADA, AK1

Compounds for genes affiliated with Hemolytic Anemia

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Sources:
24HMDB, 45Novoseek, 51PharmGKB, 11DrugBank, 3BitterDB, 29IUPHAR
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Compounds related to Hemolytic Anemia according to GeneCards/GeneDecks:

(show all 43)
idCompoundScoreTop Affiliating Genes
1Beta-D-Glucose 6-phosphate2410.2G6PD, GPI
2fructose-1,6-bisphosphate4510.2G6PD, GPI
3prpp4510.2G6PD, AK1
4sulfamethoxazole51 45 1112.1GCLC, G6PD
5starch4510.1G6PD, GPI
6isocitrate4510.1G6PD, GPI
7dADP2410.0AK1, PKLR
8actb4510.0PGK1, G6PD
9D-Glucose2410.0HK1, GPI
10glycerol 3-phosphate45 2411.0G6PD, GPI
11ddamp459.9AK1, ADA
12malate459.9G6PD, GPI
13purine nucleoside459.9G6PD, ADA
14glucose 6-phosphate45 2410.8GPI, G6PD, HK1
15phosphocreatine45 2410.8AK1, ADA
16alpha-ketoglutarate459.8GPI, G6PD, PKLR
17formate459.8ADA, G6PD
18sucrose45 24 1111.8CD59, HK1, GPI
19azathioprine45 3 51 1112.8G6PD, PGK1, CD59
202-deoxyglucose45 1110.7HK1, G6PD
21cellulose acetate459.6GPI, G6PD, ADA
22aspirin45 51 29 2412.6CD59, ADA, G6PD
23carbon459.6ADA, G6PD, GPI
24ribavirin45 51 1111.6G6PD, ADA
25glycerol45 24 1111.5HK1, ADA, G6PD
26Ammonia249.5RHAG, ADA
27hypoxanthine45 24 1111.5ADA, PGK1, G6PD
28glycogen45 2410.4GPI, PKLR, HK1
29superoxide45 2410.4CD59, PGK1, G6PD, GPI
306-phosphogluconate459.3GPI, G6PD, ADA, AK1
31fatty acid459.3CD59, HK1, PKLR
32adenylate459.3GPI, G6PD, ADA, AK1
33vitamin b12459.3ADA, G6PD
34paclitaxel45 51 1111.2ADA, PGK1, G6PD
35Adenosine triphosphate24 1110.0PGK1, AK1, PKLR, GCLC
36glyceraldehyde 3-phosphate459.0GPI, G6PD, PGK1, AK1, PKLR
37oxygen45 2410.0CD59, GCLC, HK1, PGK1, G6PD
38creatinine458.9HK1, AK1, ADA, G6PD, GPI
39adp45 29 2410.8GCLC, HK1, PKLR, AK1, PGK1
40pyruvate458.6GPI, G6PD, PGK1, AK1, PKLR, HK1
41glucose458.3GPI, G6PD, PGK1, AK1, PKLR, HK1
42lactate458.1CD59, GPI, G6PD, PGK1, ADA, AK1
43atp45 299.0G6PD, PGK1, ADA, AK1, PKLR, HK1

GO Terms for genes affiliated with Hemolytic Anemia

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16Gene Ontology
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Cellular components related to Hemolytic Anemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular vesicular exosomeGO:0700627.9GPI, G6PD, PGK1, AK1, PKLR, CD59
2plasma membraneGO:0058867.5CD59, RHAG, AK1, ADA, EPB42, GPI
3cytosolGO:0058297.0GCLC, GPI, G6PD, PGK1, ADA, AK1

Biological processes related to Hemolytic Anemia according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1glucose 6-phosphate metabolic processGO:0511569.6HK1, G6PD, GPI
2response to heatGO:0094089.5GCLC, PKLR
3nucleobase-containing small molecule metabolic processGO:0550869.5AK1, ADA
4erythrocyte maturationGO:0432499.4G6PD, EPB42
5gluconeogenesisGO:0060949.3PGK1, GPI
6glucose metabolic processGO:0060069.2PKLR, PGK1, GPI
7glycolytic processGO:0060968.9GPI, PGK1, PKLR, HK1
8carbohydrate metabolic processGO:0059758.6GPI, G6PD, PGK1, PKLR, HK1
9small molecule metabolic processGO:0442816.8GCLC, GPI, G6PD, PGK1, ADA, AK1

Molecular functions related to Hemolytic Anemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ATP bindingGO:0055247.6GCLC, HK1, PKLR, AK1, EPB42, PGK1

Products for genes affiliated with Hemolytic Anemia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hemolytic Anemia

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet