MCID: HML002
MIFTS: 56

Hemolytic Anemia malady

Genetic diseases, Blood diseases, Immune diseases, Rare diseases, Metabolic diseases categories

Aliases & Classifications for Hemolytic Anemia

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Hemolytic Anemia, Aliases & Descriptions:

Name: Hemolytic Anemia 30 9 11
Anemia Hemolytic 9 43
 
Anemia, Hemolytic 60


Classifications:



External Ids:

Disease Ontology9 DOID:583
MeSH33 D000743
NCIt38 C34376
ICD1025 D55-D59

Summaries for Hemolytic Anemia

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Wikipedia:63 Hemolytic anemia is a form of anemia due to hemolysis, the abnormal breakdown of red blood cells (RBCs),... more...

MalaCards based summary: Hemolytic Anemia, also known as anemia hemolytic, is related to autoimmune hemolytic anemia and pyruvate kinase deficiency. An important gene associated with Hemolytic Anemia is G6PD (glucose-6-phosphate dehydrogenase), and among its related pathways are Pentose Phosphate Pathway and Glutathione metabolism. The drugs tocopherols and vitamin e and the compounds Beta-D-Glucose 6-phosphate and fructose-1,6-bisphosphate have been mentioned in the context of this disorder. Affiliated tissues include testes, b cells and liver, and related mouse phenotypes are liver/biliary system and immune system.

Related Diseases for Hemolytic Anemia

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Diseases in the Hemolytic Anemia family:

Autoimmune Hemolytic Anemia Congenital Hemolytic Anemia
Hemolytic Anemia Due to Band 3 Montefiore Hemolytic Anemia Due to Erythrocyte Adenosine Deaminase Overproduction

Diseases related to Hemolytic Anemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 390)
idRelated DiseaseScoreTop Affiliating Genes
1autoimmune hemolytic anemia32.6CD59, G6PD
2pyruvate kinase deficiency31.7PKLR, G6PD
3congenital hemolytic anemia31.7GPI, G6PD, PKLR
4congenital nonspherocytic hemolytic anemia31.5PKLR, G6PD, GPI
5malaria31.3G6PD
6hereditary spherocytosis31.1EPB42, G6PD
7hemoglobinuria31.1CD59, G6PD
8paroxysmal nocturnal hemoglobinuria31.0G6PD, CD59
9hereditary elliptocytosis30.9EPB42
10systemic lupus erythematosus30.8GPI, ADA, CD59
11aplastic anemia30.4CD59, PGK1
12gaucher's disease30.1ADA, PKLR
13adenocarcinoma30.1GPI, PGK1, ADA, CD59
14deficiency anemia29.3GPI, G6PD, PGK1, PKLR, RHAG, HK1
15breast cancer29.3GPI, G6PD, PGK1, ADA, HK1, CD59
16leukemia10.9
17hepatitis10.9
18chronic lymphocytic leukemia10.8
19thrombocytopenia10.8
20warm antibody hemolytic anemia10.7
21hemolytic anemia due to hexokinase deficiency10.7
22pure red-cell aplasia10.6
23glucose-6-phosphate dehydrogenase deficiency10.6
24purpura10.6
25hepatitis c10.6
26glucose phosphate isomerase deficiency10.6
27mixed-type autoimmune hemolytic anemia10.6
28lupus erythematosus10.5
29methemoglobinemia10.5
30hodgkin lymphoma10.5
31primary biliary cirrhosis10.5
32evans' syndrome10.5
33phosphoglycerate kinase deficiency10.5
34drug-induced autoimmune hemolytic anemia10.5
35hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency10.5
36hemolytic anemia due to adenylate kinase deficiency10.5
37hemolytic anemia due to glutathione synthetase deficiency10.5
38hemolytic anemia due to g6pd deficiency10.5
39common variable immunodeficiency10.5
40thrombotic thrombocytopenic purpura10.5
41thrombotic thrombocytopenic purpura, familial10.4
42hemolytic anemia due to triosephosphate isomerase deficiency10.4
43b-cell lymphomas10.4
44hematopoietic stem cell transplantation10.4
45antiphospholipid syndrome10.4
46pneumonia10.4
47cold agglutinin disease10.4
48hepatitis c virus10.4
49hemolytic anemia, nonspherocytic, due to glucose phosphate isomerase deficiency10.4
50glutathione synthetase deficiency10.4

Graphical network of the top 20 diseases related to Hemolytic Anemia:



Diseases related to hemolytic anemia

Symptoms for Hemolytic Anemia

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Drugs & Therapeutics for Hemolytic Anemia

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Drug clinical trials:

Search ClinicalTrials for Hemolytic Anemia

Search NIH Clinical Center for Hemolytic Anemia

Inferred drug relations via UMLS60/NDF-RT39:

Show with subtypes

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Hemolytic Anemia cell therapies at LifeMap Discovery.

Genetic Tests for Hemolytic Anemia

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Anatomical Context for Hemolytic Anemia

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MalaCards organs/tissues related to Hemolytic Anemia:

31
Testes, B cells, Liver, T cells, Bone, Kidney, Bone marrow, Spleen, Lung, Heart, Thyroid, Myeloid, Colon, Breast, Monocytes, Endothelial, Brain, Spinal cord, Pancreas, Ovary, Cervix, Nk cells, Neutrophil

Animal Models for Hemolytic Anemia or affiliated genes

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MGI Mouse Phenotypes related to Hemolytic Anemia:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.7GCLC, HK1, ADA, GPI
2MP:00053877.1GPI, EPB42, ADA, PKLR, HK1, GCLC
3MP:00053976.2GPI, G6PD, EPB42, ADA, PKLR, RHAG
4MP:00053766.0CD59, GPI, G6PD, EPB42, ADA, AK1

Publications for Hemolytic Anemia

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Articles related to Hemolytic Anemia:

(show top 50)    (show all 1248)
idTitleAuthorsYear
1
Vitamin B12 and vitamin d deficiencies: an unusual cause of Fever, severe hemolytic anemia and thrombocytopenia. (25811010)
2015
2
The complex morphology of acute kidney injury with microangiopathic hemolytic anemia and hyposplenism. (25820529)
2015
3
Pure red-cell aplasia and autoimmune hemolytic anemia in a patient with acute hepatitis A. (25032187)
2014
4
Coombs negative autoimmune hemolytic anemia in Crohn's disease. (25488633)
2014
5
Thrombotic thrombocytopenic purpura and other thrombotic microangiopathic hemolytic anemias: Diagnosis and classification. (24418304)
2014
6
Drug-induced immune hemolytic anemia: the last 30 years of changes. (25247622)
2014
7
Hb Youngstown [I^101(G3)Glua88a89a88Ala; HBB: c.305Aa88>a88C]: An Unstable Hemoglobin Variant Causing Severe Hemolytic Anemia. (25347256)
2014
8
A mixed-type autoimmune hemolytic anemia with immune thrombocytopenia related with myositis and post-transplantation lymphoproliferative disorder. (24013519)
2013
9
The first example of a patient with etoricoxib-induced immune hemolytic anemia. (22882551)
2013
10
SLE with diffuse alveolar hemorrhage, microangiopathic hemolytic anemia and acute renal failure. (22730045)
2012
11
Splenic infarction, warm autoimmune hemolytic anemia and antiphospholipid antibodies associated with systemic lupus erythematosus. (22623174)
2012
12
Low-dose rituximab in adult patients with idiopathic autoimmune hemolytic anemia: clinical efficacy and biologic studies. (22267606)
2012
13
Incidence of congenital hemolytic anemias in young cholelithiasis patients. (21086564)
2010
14
Trimethoprim-induced immune hemolytic anemia in a pediatric oncology patient presenting as an acute hemolytic transfusion reaction. (20589632)
2010
15
Treatment of immune-mediated hemolytic anemia with individually adjusted heparin dosing in dogs. (20384956)
2010
16
Autoimmune hemolytic anemia as a risk factor of poor outcome in patients with splenic marginal zone lymphoma. (19343544)
2009
17
The role of oxidative stress in hemolytic anemia. (18991647)
2008
18
Pulmonary hypertension associated with autoimmune hemolytic anemia: a case report. (16889843)
2007
19
Cardiac hypertrophy in anion exchanger 1-null mutant mice with severe hemolytic anemia. (17056673)
2007
20
Review: pharmacologic treatment of warm autoimmune hemolytic anemia. (18284301)
2007
21
Severe autoimmune hemolytic anemia after unrelated umbilical cord blood transplant for familial hemophagocytic lymphohistiocytosis: significant improvement after treatment with rituximab. (17279011)
2007
22
Management of cold agglutinin immune hemolytic anemia in pregnancy. (17666637)
2007
23
Autoimmune hemolytic anemia in an elderly patient with primary SjAPgren's syndrome. (16415556)
2005
24
Successful treatment with cyclosporine and high-dose gamma immunoglobulin for persistent parvovirus B19 infection in a patient with refractory autoimmune hemolytic anemia. (15540900)
2004
25
Hemolytic anemia and severe rhabdomyolysis caused by compound heterozygous mutations of the gene for erythrocyte/muscle isozyme of aldolase, ALDOA(Arg303X/Cys338Tyr). (14615364)
2004
26
A case of autoimmune hepatitis and autoimmune hemolytic anemia following hepatitis A infection. (14655068)
2003
27
Sinus histiocytosis with massive lymphadenopathy: complicated by autoimmune hemolytic anemia. (14620195)
2003
28
Autoimmune hemolytic anemia associated with Crohn's disease. (11854607)
2002
29
An adolescent with hemolytic anemia and coagulation disorders as manifestation of Wilson's disease, treated with liver transplantation]. (11234295)
2001
30
Severe Coombs'-negative autoimmune hemolytic anemia in a kidney transplant patient. (11799268)
2001
31
Hemolytic anemia after acetaminophen overdose in patient with glucose-6-phosphate dehydrogenase deficiency. (11221636)
2001
32
Eight novel mutations and consequences on mRNA and protein level in pyruvate kinase-deficient patients with nonspherocytic hemolytic anemia. (10679942)
2000
33
Molecular analysis of 29 pyruvate kinase-deficient patients from central Europe with hereditary hemolytic anemia. (9057665)
1997
34
Direct Coombs test-negative autoimmune hemolytic anemia and low-affinity IgG class antibodies. (15387763)
1997
35
Missense mutations in the human glutathione synthetase gene result in severe metabolic acidosis, 5-oxoprolinuria, hemolytic anemia and neurological dysfunction. (9215686)
1997
36
Hemolytic anemia as cause of a marked bilirubin increase in primary biliary cirrhosis]. (8925755)
1996
37
Autoimmune hemolytic anemia in a patient with idiopathic hypereosinophilia. (7639285)
1995
38
High cytokine serum levels in patients with autoimmune hemolytic anemia (AIHA). (7851962)
1994
39
Clinical features and splenic pathologic changes in patients with autoimmune hemolytic anemia and congenital hemolytic anemia. (8331977)
1993
40
Broad beans as a cause of acute hemolytic anemia]. (8519217)
1993
41
Homozygous hereditary elliptocytosis with hemolytic anemia. (6719166)
1984
42
G6PD San Francisco: a new variant of glucose-6-phosphate dehydrogenase associated with congenital nonspherocytic hemolytic anemia. (7353069)
1980
43
Animal model of human disease. Congenital hemolytic anemia. (4715956)
1973
44
Functionally abnormal pyruvate kinase in congenital hemolytic anemia. (5388241)
1969
45
Erythrocyte pyruvate kinase deficiency in non-spherocytic hemolytic anemia: a system of multiple genetic markers? (5658389)
1968
46
Microangiopathic hemolytic anemia caused by purpura fulminans. (5653626)
1968
47
Warm antibody hemolytic anemia; prolonged remission despite persistent positive Coombs test. (5310347)
1968
48
A case of congenital hemolytic anemia with hypersplenism. Remission of 24 years following splenectomy and recurrence due to an accessory spleen visualized by thoratrast. (14418071)
1960
49
Renal hemosiderosis in the hemolytic anemias: diagnosis by means of needle biopsy. (14415802)
1960
50
Congenital hemolytic anemia in the Negro. (15432084)
1950

Variations for Hemolytic Anemia

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Expression for genes affiliated with Hemolytic Anemia

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Search GEO for disease gene expression data for Hemolytic Anemia.

Pathways for genes affiliated with Hemolytic Anemia

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Pathways related to Hemolytic Anemia according to GeneCards Suite gene sharing:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
pentose phosphate pathway (non-oxidative branch)36
pentose phosphate pathway36
PRPP biosynthesis36
9.8G6PD, GPI
2
Show member pathways
glutathione-mediated detoxification I36
glutathione redox reactions I36
glutathione redox reactions II36
4-hydroxy-2-nonenal detoxification36
Glutathione metabolism58
Glutathione metabolism36
9.8GCLC, G6PD
3
Show member pathways
colanic acid building blocks biosynthesis36
N-acetylglucosamine degradation I36
CMP-N-acetylneuraminate biosynthesis I (eukaryotes)36
UDP-D-xylose and UDP-D-glucuronate biosynthesis36
N-acetylglucosamine degradation II36
UDP-N-acetyl-D-glucosamine biosynthesis II36
UDP-N-acetyl-D-galactosamine biosynthesis II36
GDP-L-fucose biosynthesis I (from GDP-D-mannose)36
9.7HK1, GPI
4
Show member pathways
9.6PKLR, HK1
59.5HK1, PGK1
6
Show member pathways
guanosine nucleotides de novo biosynthesis36
guanosine ribonucleotides de novo biosynthesis36
adenosine ribonucleotides de novo biosynthesis36
purine nucleotides de novo biosynthesis36
9.5ADA, AK1
79.5PKLR, PGK1
8
Show member pathways
One Carbon Metabolism36
dTMP de novo biosynthesis (mitochondrial)36
tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate36
Trans-sulfuration and one carbon metabolism36
methionine salvage36
Methionine metabolism58
9.5GCLC, ADA
9
Show member pathways
malate-aspartate shuttle36
glycogen biosynthesis II (from UDP-D-Glucose)36
9.2PKLR, PGK1, GPI
10
Show member pathways
TCA cycle36
pyruvate decarboxylation to acetyl CoA36
NAD phosphorylation and dephosphorylation36
TCA Cycle36
conversion of glucose to acetyl CoA and entry into the TCA cycle36
9.1PGK1, PKLR, HK1
11
Show member pathways
UTP and CTP dephosphorylation II36
ATP ITP metabolism58
purine deoxyribonucleosides salvage36
9.1ADA, AK1, PKLR
12
Show member pathways
glycolysis36
gluconeogenesis36
Glycolysis and Gluconeogenesis36
8.7HK1, PKLR, PGK1, GPI
13
Show member pathways
L-serine degradation36
pentose phosphate pathway (oxidative branch)36
formaldehyde oxidation II (glutathione-dependent)36
8.5GPI, G6PD, PGK1, PKLR, HK1
14
Show member pathways
8.5GPI, G6PD, PGK1, PKLR, HK1
15
Show member pathways
6.6GCLC, GPI, G6PD, PGK1, ADA, AK1

Compounds for genes affiliated with Hemolytic Anemia

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Sources:
24HMDB, 43Novoseek, 49PharmGKB, 12DrugBank, 2BitterDB, 28IUPHAR
See all sources

Compounds related to Hemolytic Anemia according to GeneCards Suite gene sharing:

(show all 43)
idCompoundScoreTop Affiliating Genes
1Beta-D-Glucose 6-phosphate2410.2G6PD, GPI
2fructose-1,6-bisphosphate4310.2G6PD, GPI
3prpp4310.2G6PD, AK1
4sulfamethoxazole49 43 1212.1GCLC, G6PD
5starch4310.1G6PD, GPI
6isocitrate4310.1G6PD, GPI
7dADP2410.0AK1, PKLR
8actb4310.0PGK1, G6PD
9D-Glucose2410.0HK1, GPI
10glycerol 3-phosphate43 2411.0G6PD, GPI
11ddamp439.9AK1, ADA
12malate439.9G6PD, GPI
13purine nucleoside439.9G6PD, ADA
14glucose 6-phosphate43 2410.8GPI, G6PD, HK1
15phosphocreatine43 2410.8AK1, ADA
16alpha-ketoglutarate439.8GPI, G6PD, PKLR
17formate439.8ADA, G6PD
18sucrose43 24 1211.8CD59, HK1, GPI
19azathioprine43 2 49 1212.8G6PD, PGK1, CD59
202-deoxyglucose43 1210.7HK1, G6PD
21cellulose acetate439.6GPI, G6PD, ADA
22aspirin43 49 28 2412.6CD59, ADA, G6PD
23carbon439.6ADA, G6PD, GPI
24ribavirin43 49 1211.6G6PD, ADA
25glycerol43 24 1211.5HK1, ADA, G6PD
26Ammonia249.5RHAG, ADA
27hypoxanthine43 24 1211.5ADA, PGK1, G6PD
28glycogen43 2410.4GPI, PKLR, HK1
29superoxide43 2410.4CD59, PGK1, G6PD, GPI
306-phosphogluconate439.3GPI, G6PD, ADA, AK1
31fatty acid439.3CD59, HK1, PKLR
32adenylate439.3GPI, G6PD, ADA, AK1
33vitamin b12439.3ADA, G6PD
34paclitaxel43 49 1211.2ADA, PGK1, G6PD
35Adenosine triphosphate24 1210.0PGK1, AK1, PKLR, GCLC
36glyceraldehyde 3-phosphate439.0GPI, G6PD, PGK1, AK1, PKLR
37oxygen43 2410.0CD59, GCLC, HK1, PGK1, G6PD
38creatinine438.9HK1, AK1, ADA, G6PD, GPI
39adp43 28 2410.8GCLC, HK1, PKLR, AK1, PGK1
40pyruvate438.6GPI, G6PD, PGK1, AK1, PKLR, HK1
41glucose438.3GPI, G6PD, PGK1, AK1, PKLR, HK1
42lactate438.1CD59, GPI, G6PD, PGK1, ADA, AK1
43atp43 289.0G6PD, PGK1, ADA, AK1, PKLR, HK1

GO Terms for genes affiliated with Hemolytic Anemia

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Cellular components related to Hemolytic Anemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular vesicular exosomeGO:00700627.9GPI, G6PD, PGK1, AK1, PKLR, CD59
2plasma membraneGO:00058867.5CD59, RHAG, AK1, ADA, EPB42, GPI
3cytosolGO:00058297.0GCLC, GPI, G6PD, PGK1, ADA, AK1

Biological processes related to Hemolytic Anemia according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1glucose 6-phosphate metabolic processGO:00511569.6HK1, G6PD, GPI
2response to heatGO:00094089.5GCLC, PKLR
3nucleobase-containing small molecule metabolic processGO:00550869.5AK1, ADA
4erythrocyte maturationGO:00432499.4G6PD, EPB42
5gluconeogenesisGO:00060949.3PGK1, GPI
6glucose metabolic processGO:00060069.2PKLR, PGK1, GPI
7glycolytic processGO:00060968.9GPI, PGK1, PKLR, HK1
8carbohydrate metabolic processGO:00059758.6GPI, G6PD, PGK1, PKLR, HK1
9small molecule metabolic processGO:00442816.8GCLC, GPI, G6PD, PGK1, ADA, AK1

Molecular functions related to Hemolytic Anemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1ATP bindingGO:00055247.6GCLC, HK1, PKLR, AK1, EPB42, PGK1

Products for genes affiliated with Hemolytic Anemia

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  • Antibodies
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  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Hemolytic Anemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet