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HUS
MCID: HML001
MIFTS: 52

Hemolytic-Uremic Syndrome (HUS) malady

Nephrological, Blood categories
89 genes, 14 tissues, 214 related diseases, clinical trials.

Summaries for Hemolytic-Uremic Syndrome

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64Wikipedia, 33MalaCards
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Wikipedia:64 Hemolytic-uremic syndrome (or haemolytic-uraemic syndrome), abbreviated HUS, is a disease characterized... more...

MalaCards: Hemolytic-Uremic Syndrome, also known as hemolytic uremic syndrome, is related to atypical hemolytic-uremic syndrome and protein s deficiency. An important gene associated with Hemolytic-Uremic Syndrome is CFH (complement factor H), and among its related pathways are Activation of C3 and C5 and Classical Complement Pathway. The compounds cardiolipin and desmopressin have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and heart, and related mouse phenotypes are renal/urinary system and homeostasis/metabolism.

Aliases & Classifications for Hemolytic-Uremic Syndrome

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8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 61UMLS, 35MeSH, 40NCIt, 57SNOMED-CT, 27ICD9CM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological, Blood


Aliases & Descriptions:

hemolytic-uremic syndrome 8 10 45 61
hemolytic uremic syndrome 8 43
acute renal failure, thrombocytopenia, and microangiopathic hemolytic anemia associated with distorted erythrocytes 43
hus 43


External Ids:

Disease Ontology8 DOID:12554
MeSH35 D006463
NCIt40 C75545
ICD9CM27 283.11

Related Diseases for Hemolytic-Uremic Syndrome

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17GeneCards, 18GeneDecks
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Diseases related to Hemolytic-Uremic Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 214)
idRelated DiseaseScoreTop Affiliating Genes
1atypical hemolytic-uremic syndrome32.0CFHR1, CFHR3
2protein s deficiency30.8C4BPB, C4BPA
3membranoproliferative glomerulonephritis30.6CD46, CFH, C3
4hellp syndrome30.4VWF, ADAMTS13
5arthritis30.2SULT1A3, C3
6antiphospholipid syndrome30.2SULT1A3, THBD, VWF, CFH, ADAMTS13
7sepsis30.2SULT1A3, CFB, THBD, C3, ADAMTS13
8vascular disease30.2CD46, VWF, THBD, SULT1A3
9systemic lupus erythematosus30.2C4BPA, ADAMTS13, VWF, CD46, C4B, CFH
10adenocarcinoma30.2MLH1, MSH2, THBD, CD46
11systemic scleroderma30.2THBD, CD46, VWF
12acute myocardial infarction29.8ADAMTS13, THBD, VWF, SULT1A3
13transitional cell carcinoma29.8MLH1, THBD, MSH2
14n syndrome11.1
15thrombotic thrombocytopenic purpura11.0
16adult syndrome10.8
17micro syndrome10.8
18kid syndrome10.8
19char syndrome10.6
20complement factor h deficiency10.6
21complement factor d deficiency10.6
22anuria10.5
23protein c deficiency10.5
24hemolytic uremic syndrome, atypical 210.5
25hemolytic uremic syndrome, atypical, childhood10.5
26german syndrome10.5
27nephrosclerosis10.4
28shigellosis10.4
29acute leukemia10.4
30protein r deficiency10.4
31cfh-related atypical hemolytic-uremic syndrome10.4
32hemolytic uremic syndrome, atypical 110.4
33hemolytic uremic syndrome, atypical 310.4
34hemolytic uremic syndrome, atypical 410.4
35hemolytic uremic syndrome, atypical 510.4
36hemolytic uremic syndrome, atypical 610.4
37acute pancreatitis10.4
38acute diarrhea10.4
39short syndrome10.4
40d-minus hemolytic uremic syndrome10.4
41d-plus hemolytic uremic syndrome10.4
42crohn's disease10.3
43hyperuricemia10.3
44plasmodium vivax malaria10.3
45central retinal vein occlusion10.3
46emphysematous cholecystitis10.3
47conn's syndrome10.3
48autism spectrum disorder10.3
49thrombophilia10.3
50young syndrome10.3

Graphical network of the top 20 diseases related to Hemolytic-Uremic Syndrome:



Diseases related to hemolytic-uremic syndrome

Clinical Features for Hemolytic-Uremic Syndrome

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Drugs & Therapeutics for Hemolytic-Uremic Syndrome

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Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Hemolytic-Uremic Syndrome

Drug clinical trials:

Search ClinicalTrials for Hemolytic-Uremic Syndrome

Search NIH Clinical Center for Hemolytic-Uremic Syndrome

Search CenterWatch for Hemolytic-Uremic Syndrome

Genetic Tests for Hemolytic-Uremic Syndrome

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Anatomical Context for Hemolytic-Uremic Syndrome

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33MalaCards
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MalaCards organs/tissues related to Hemolytic-Uremic Syndrome:

33
Bone marrow, Whole blood, Heart, Kidney, Liver, Lung, Pancreas, Skin, Prostate, Monocytes, T cells, B lymphoblasts, B cells, Endothelial

Animal Models for Hemolytic-Uremic Syndrome or affiliated genes

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37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Hemolytic-Uremic Syndrome:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1
renal/urinary system phenotype
MP:000536710.4CFI, CFB, CFH, THBD, C3, C4B
2
homeostasis/metabolism phenotype
MP:00053769.9ADAMTS13, FHL1, C4B, MLH1, VWF, CFI

Publications for Hemolytic-Uremic Syndrome

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51PubMed
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Articles related to Hemolytic-Uremic Syndrome:

(show top 50)    (show all 691)
idTitleAuthorsYear
1
Alcohol-induced severe acute pancreatitis followed by hemolytic uremic syndrome managed with continuous renal replacement therapy. (24386889)
2014
2
Untying the knot of thrombotic thrombocytopenic purpura and atypical hemolytic uremic syndrome. (23410558)
2013
3
Postoperative hemolytic uremic syndrome with renal cortical necrosis following laparoscopic hemicolectomy. (23560430)
2013
4
Terminal complement inhibitor eculizumab in atypical hemolytic-uremic syndrome. (23738544)
2013
5
Verocytotoxin-producing Escherichia coli O128ab:H2 bacteremia in a 27-year-old male with hemolytic-uremic syndrome. (23467596)
2013
6
Genetics and outcome of atypical hemolytic uremic syndrome: a nationwide French series comparing children and adults. (23307876)
2013
7
Advanced prostate cancer presenting as hemolytic uremic syndrome. (23738188)
2013
8
Case series: hemolytic uremic syndrome--another cause of transplant dysfunction. (24182801)
2013
9
Two cases of hemolytic uremic syndrome caused by Streptococcus pneumoniae serotype 3, one being a vaccine failure. (23270474)
2013
10
Treatment of atypical hemolytic uremic syndrome and thrombotic microangiopathies: a focus on eculizumab. (23141475)
2013
11
Hemolytic uremic syndrome: sound minds, sick kidneys. (23659611)
2013
12
Outbreak of hemolytic uremic syndrome caused by E. coli O104:H4 in Germany: a pediatric perspective. (22160440)
2012
13
Eculizumab for atypical hemolytic uremic syndrome recurrence in renal transplantation. (22958221)
2012
14
Lack of the lectin-like domain of thrombomodulin worsens Shiga toxin-associated hemolytic uremic syndrome in mice. (22942429)
2012
15
Familial atypical hemolytic uremic syndrome: a review of its genetic and clinical aspects. (23251215)
2012
16
Shiga toxin-associated hemolytic uremic syndrome: advances in pathogenesis and therapeutics. (22660553)
2012
17
Management of hemolytic uremic syndrome. (22284541)
2012
18
Overall neutralization of complement factor H by autoantibodies in the acute phase of the autoimmune form of atypical hemolytic uremic syndrome. (22922817)
2012
19
Successful therapeutic plasma exchange in a 3.2-kg body weight neonate with atypical hemolytic uremic syndrome. (21322001)
2011
20
Outbreak of hemolytic-uremic syndrome linked to Shiga toxin-producing enteroaggregative Escherichia coli O104:H4. (21822097)
2011
21
Postdiarrheal hemolytic uremic syndrome in persons aged 65 and older in foodnet sites, 2000-2006. (21314655)
2011
22
Hemolysis and hemolytic uremic syndrome following five-fold N-acetylcysteine overdose. (21970774)
2011
23
Chemiluminescence determination of antioxidant property of Zizyphus mistol and Prosopis alba during oxidative stress generated in blood by Hemolytic Uremic Syndrome-producing Escherichia coli. (20842653)
2011
24
Nonenteropathic hemolytic uremic syndrome: the experience of a medical center. (21524626)
2011
25
Diarrhea-related hemolytic uremic syndrome: unmasking antifactor H antibodies. (21912037)
2011
26
Recent outbreak of hemolytic uremic syndrome in Germany. (21997502)
2011
27
Shiga toxin-associated hemolytic uremic syndrome: pathophysiology of endothelial dysfunction. (20424866)
2010
28
Enterohemorrhagic Escherichia coli O26:H11-Associated Hemolytic Uremic Syndrome: Bacteriology and Clinical Presentation. (20865635)
2010
29
The binding of factor H to a complex of physiological polyanions and C3b on cells is impaired in atypical hemolytic uremic syndrome. (19454698)
2009
30
Escherichia coli O-157-induced hemolytic uremic syndrome: Usefulness of SCWP score for the prediction of neurological complication. (19371288)
2009
31
Thrombomodulin in atypical hemolytic-uremic syndrome. (19812413)
2009
32
Consumption of unpasteurized milk as a risk factor for hemolytic uremic syndrome in Italian children. (19416031)
2009
33
Liver-kidney transplantation to cure atypical hemolytic uremic syndrome. (19092117)
2009
34
Hemolytic uremic syndrome due to homozygous factor H deficiency. (19568827)
2009
35
The diagnostic dilemma of thrombotic thrombocytopenic purpura/hemolytic uremic syndrome in the obstetric triage and emergency department: lessons from 4 tertiary hospitals. (19110215)
2009
36
Efficacy of plasma therapy in atypical hemolytic uremic syndrome with complement factor H mutations. (18425537)
2008
37
Complement and the atypical hemolytic uremic syndrome in children. (18594873)
2008
38
Association of a factor H mutation with hemolytic uremic syndrome following a diarrheal illness. (18295065)
2008
39
Complement regulatory genes and hemolytic uremic syndromes. (17705684)
2008
40
Update on evaluating complement in hemolytic uremic syndrome. (18089972)
2007
41
Unusual clinical severity of complement membrane cofactor protein-associated hemolytic-uremic syndrome and uniparental isodisomy. (17261436)
2007
42
Hereditary hemolytic uremic syndromes and thrombotic thrombocytopenic purpura]. (17373216)
2006
43
Lipopolysaccharide from enterohemorrhagic Escherichia coli binds to platelets through TLR4 and CD62 and is detected on circulating platelets in patients with hemolytic uremic syndrome. (16514062)
2006
44
ADAMTS13 activity in thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: relation to presenting features and clinical outcomes in a prospective cohort of 142 patients. (12637323)
2003
45
Circulating granulocyte colony-stimulating factor, C-X-C, and C-C chemokines in children with Escherichia coli O157:H7 associated hemolytic uremic syndrome. (12438672)
2002
46
Circulating inflammatory cytokine levels in hemolytic uremic syndrome. (10603133)
1999
47
A 12-year-old boy with fatal hemolytic-uremic-syndrome, excessive neutrophilia and elevated endogenous granulocyte-colony-stimulating-factor serum concentrations. (9710348)
1998
48
Clostridium septicum infection and hemolytic uremic syndrome. (9621207)
1998
49
Typical and atypical hemolytic uremic syndrome. (8887262)
1996
50
Tumor necrosis factor and interleukin-1 induce expression of the verocytotoxin receptor globotriaosylceramide on human endothelial cells: implications for the pathogenesis of the hemolytic uremic syndrome. (1333300)
1992

Genetic Variations for Hemolytic-Uremic Syndrome

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Expression for genes affiliated with Hemolytic-Uremic Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hemolytic-Uremic Syndrome

Search GEO for disease gene expression data for Hemolytic-Uremic Syndrome.

Pathways for genes affiliated with Hemolytic-Uremic Syndrome

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54Reactome, 52QIAGEN, 38NCBI BioSystems Database, 56SinoBiological, 30KEGG, 12EMD Millipore
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Pathways related to Hemolytic-Uremic Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Activation of C3 and C554
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10.4C3, CFB
2
Classical Complement Pathway52
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10.4C3, CD46, C4B, CFH
3
Immune System54
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10.4CFH, C3, CFHR3, CFI, CFB
4
Staphylococcus aureus infection30
10.4C4B, CFI, C3, CFB, CFH
5
Classical antibody-mediated complement activation54
Hide members
10.4CFB, CFI, CFHR3, CD46, CFH, C3
6
Pertussis30
10.4C4BPB, C3, C4B, C4BPA
7
Immune response Lectin induced complement pathway
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10.3C4BPA, C4BPB, C4B, C3, CFH, CFB
8
Complement and coagulation cascades30
Hide members
10.3C4BPB, C4BPA, C3, THBD, CFH, CFB

Compounds for genes affiliated with Hemolytic-Uremic Syndrome

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45Novoseek, 11DrugBank, 60Tocris Bioscience, 29IUPHAR, 50PharmGKB, 24HMDB
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Compounds related to Hemolytic-Uremic Syndrome according to GeneCards/GeneDecks:

(show all 32)
idCompoundScoreTop Affiliating Genes
1cardiolipin45 1111.8CFH
2desmopressin45 60 29 1113.8VWF, THBD, ADAMTS13
3nacl4510.8CFI, CFH, THBD, SULT1A3, ADAMTS13
4serine4510.8C4BPB, CD46, MSH2, C3, ADAMTS13
5cyclophosphamide45 50 1112.7ADAMTS13, THBD, VWF, CD46
6carbohydrates4510.7THBD, CFI, VWF, C4B
7agarose4510.7C4B, MLH1, VWF, CFB, THBD, C3
8beraprost sodium4510.7VWF, THBD
9creatinine4510.7VWF, CFI, THBD, SULT1A3, C3, ADAMTS13
10cholesterol45 29 11 2413.7C4BPA, VWF, CFI, CFH, THBD, SULT1A3
11fibrinogen4510.7C4BPA, VWF, CFI, CFH, THBD, SULT1A3
12cyclosporin a45 29 6012.7CD46, VWF, CFH, THBD, ADAMTS13
13kininogen4510.7THBD, CFI, VWF
14paraffin4510.7MLH1, CD46, VWF, THBD, MSH2
15n-methyl-n-nitrosourea4510.7MSH2, MLH1
16alanine4510.7C4BPB, MLH1, CD46, VWF, CFH, THBD
17dexamethasone45 50 29 1113.7CD46, VWF, CFH, THBD, SULT1A3, C3
18aspirin45 50 29 2413.7SULT1A3, THBD, VWF, MLH1
19Intravenous Immunoglobulin1110.7C3, C4B
20steroid4510.7ADAMTS13, C3, SULT1A3, THBD, MLH1, C4B
21heparin45 29 11 2413.7ADAMTS13, C4BPA, C4BPB, CFHR4, CFI, CFHR2
22methionine4510.6MLH1, VWF, CFI, THBD
23polysaccharide4510.6CD46, CFH, THBD, C3
24estrogen4510.6MLH1, VWF, CFI, THBD, SULT1A3, C3
2511-dehydrothromboxane b24510.6THBD, VWF
26progesterone45 60 29 11 2414.6C3, SULT1A3, THBD, CD46, MLH1
27phospholipid4510.5C3, THBD, VWF, C4BPB
28biotin45 11 2412.5MLH1, VWF, MSH2
29homocysteine45 2411.4SULT1A3, THBD, VWF
306-ketoprostaglandin f1alpha4510.3VWF, THBD
31calcium45 50 11 2413.3C4BPB, C4B, MLH1, CD46, VWF, CFI
32mononucleotide4510.1MLH1, MSH2

GO Terms for genes affiliated with Hemolytic-Uremic Syndrome

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16Gene Ontology
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Cellular components related to Hemolytic-Uremic Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.4CFHR3, CFI, CFH, CFHR1, C3, ADAMTS13
2extracellular regionGO:0055769.9C3, C4BPA, C4BPB, C4B, VWF, CFHR4

Biological processes related to Hemolytic-Uremic Syndrome according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1regulation of complement activationGO:03044910.5C3, CFH, CFB, CFI, CD46, C4B
2complement activationGO:00695610.5C3, CFH, CFHR1, CFB, C4B
3complement activation, classical pathwayGO:00695810.5C4BPB, C4B, CD46, CFI, C3, C4BPA
4isotype switchingGO:04519010.4MSH2, MLH1
5complement activation, alternative pathwayGO:00695710.4C3, CFHR5, CFH, CFB
6innate immune responseGO:04508710.2CFI, CD46, CFB, CFH, C4BPB, C3
7somatic hypermutation of immunoglobulin genesGO:01644610.1MSH2, MLH1

Molecular functions related to Hemolytic-Uremic Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1guanine/thymine mispair bindingGO:03213710.4MSH2, MLH1
2complement bindingGO:00184810.1CFB, CD46

Products for genes affiliated with Hemolytic-Uremic Syndrome

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  • Antibodies
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  • Antibodies

Sources for Hemolytic-Uremic Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet
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