HUS
MCID: HML001
MIFTS: 48

Hemolytic-Uremic Syndrome (HUS) malady

Rare diseases, Blood diseases, Nephrological diseases categories
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Summaries for Hemolytic-Uremic Syndrome

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65Wikipedia, 33MalaCards
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Wikipedia:65 Hemolytic-uremic syndrome (or haemolytic-uraemic syndrome), abbreviated HUS, is a disease characterized... more...

MalaCards: Hemolytic-Uremic Syndrome, also known as hemolytic uremic syndrome, is related to atypical hemolytic-uremic syndrome and complement factor h deficiency. An important gene associated with Hemolytic-Uremic Syndrome is CFH (complement factor H), and among its related pathways are Staphylococcus aureus infection and Complement and coagulation cascades. The compounds sialic acid and heparin have been mentioned in the context of this disorder. Affiliated tissues include kidney, endothelial and liver, and related mouse phenotype renal/urinary system.

Aliases & Classifications for Hemolytic-Uremic Syndrome

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 43NIH Rare Diseases, 58SNOMED-CT, 40NCIt, 27ICD9CM, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Blood diseases, Nephrological diseases


Aliases & Descriptions:

hemolytic-uremic syndrome 8 10 45 62
hemolytic uremic syndrome 8 43
acute renal failure, thrombocytopenia, and microangiopathic hemolytic anemia associated with distorted erythrocytes 43
hus 43


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Disease Ontology8 DOID:12554
NCIt40 C75545
ICD9CM27 283.11
MeSH35 D006463

Related Diseases for Hemolytic-Uremic Syndrome

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17GeneCards, 18GeneDecks
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Diseases in the Hemolytic-Uremic Syndrome family:

D-Plus Hemolytic Uremic Syndrome

Diseases related to Hemolytic-Uremic Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 205)
idRelated DiseaseScoreTop Affiliating Genes
1atypical hemolytic-uremic syndrome32.1CFHR1, CFHR3
2complement factor h deficiency30.9CFH
3glomerulonephritis30.8CD46, CFI, CFH
4membranoproliferative glomerulonephritis30.7CD46, CFH
5meningitis30.2CD46, CFI
6systemic lupus erythematosus30.2CFI, CFH, CD46
7age related macular degeneration30.1CFH, CFB, CFHR3, CFHR1
8purpura11.0
9thrombotic thrombocytopenic purpura11.0
10diarrhea10.8
11pneumonia10.8
12endotheliitis10.7
13pancreatitis10.6
14anuria10.6
15hypertension10.6
16influenza10.6
17hemolytic uremic syndrome, atypical 210.6
18hemolytic uremic syndrome, atypical, childhood10.5
19nephrosclerosis10.5
20shigellosis10.5
21leukemia10.5
22malignant hypertension10.5
23hemolytic uremic syndrome, atypical 310.5
24hemolytic uremic syndrome, atypical 410.5
25hemolytic uremic syndrome, atypical 510.5
26hemolytic uremic syndrome, atypical 610.5
27cerebritis10.4
28disseminated intravascular coagulation10.4
29malaria10.4
30pertussis10.4
31d-minus hemolytic uremic syndrome10.4
32d-plus hemolytic uremic syndrome10.4
33neuronitis10.4
34crohn's disease10.3
35hyperuricemia10.3
36acute pancreatitis10.3
37plasmodium vivax malaria10.3
38emphysematous cholecystitis10.3
39hellp syndrome10.3
40cholecystitis10.3
41dysentery10.3
42peritonitis10.3
43prostate cancer10.3
44prostatitis10.3
45thrombophilia10.3
46cd46-related atypical hemolytic-uremic syndrome10.3
47cfb-related atypical hemolytic-uremic syndrome10.3
48cfh-related atypical hemolytic-uremic syndrome10.3
49cfi-related atypical hemolytic-uremic syndrome10.3
50thbd-related atypical hemolytic-uremic syndrome10.3

Graphical network of the top 20 diseases related to Hemolytic-Uremic Syndrome:



Diseases related to hemolytic-uremic syndrome

Symptoms for Hemolytic-Uremic Syndrome

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Drugs & Therapeutics for Hemolytic-Uremic Syndrome

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Hemolytic-Uremic Syndrome

Search NIH Clinical Center for Hemolytic-Uremic Syndrome

Genetic Tests for Hemolytic-Uremic Syndrome

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Anatomical Context for Hemolytic-Uremic Syndrome

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33MalaCards
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MalaCards organs/tissues related to Hemolytic-Uremic Syndrome:

33
Kidney, Endothelial, Liver, Lung, Prostate, Pancreas, Monocytes, Heart, Bone marrow, Testes, Bone, Skin

Animal Models for Hemolytic-Uremic Syndrome or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Hemolytic-Uremic Syndrome:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.7CFI, CFB, CFH

Publications for Hemolytic-Uremic Syndrome

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52PubMed
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Articles related to Hemolytic-Uremic Syndrome:

(show top 50)    (show all 677)
idTitleAuthorsYear
1
Enterohemorrhagic Escherichia coli Infections and the Hemolytic-Uremic Syndrome. (23809720)
2013
2
Hemolytic uremic syndrome related to cryptosporidium infection in an immunocompetent child. (24330289)
2013
3
Multifaceted hemolytic uremic syndrome in pediatrics. (23343552)
2013
4
Untying the knot of thrombotic thrombocytopenic purpura and atypical hemolytic uremic syndrome. (23410558)
2013
5
Eculizumab in atypical hemolytic-uremic syndrome. (24088108)
2013
6
Early infantile onset of atypical hemolytic-uremic syndrome is caused by recessive mutations in DGKE. (23875923)
2013
7
Adult hemolytic uremic syndrome associated with Streptococcus pneumoniae. (23380391)
2013
8
Peripheral gangrene in children with atypical hemolytic uremic syndrome. (23230076)
2013
9
Factor I autoantibodies in patients with atypical hemolytic uremic syndrome: disease-associated or an epiphenomenon? (22223611)
2012
10
Interpretation of genetic variants of uncertain significance in atypical hemolytic uremic syndrome. (22170528)
2012
11
Complement factor H variants I890 and L1007 while commonly associated with atypical hemolytic uremic syndrome are polymorphisms with no functional significance. (21881555)
2012
12
Atypical hemolytic uremic syndrome-associated variants and autoantibodies impair binding of factor h and factor h-related protein 1 to pentraxin 3. (22786770)
2012
13
Hemorrhagic colitis in postdiarrheal hemolytic uremic syndrome: retrospective analysis of 54 children. (21809003)
2012
14
Eculizumab therapy in a child with hemolytic uremic syndrome and CFI mutation. (22903728)
2012
15
Severe Bordetella pertussis infection associated with hemolytic uremic syndrome. (22953627)
2012
16
Renal transplantation under prophylactic eculizumab in atypical hemolytic uremic syndrome with CFH/CFHR1 hybrid protein. (22494769)
2012
17
Efficacy of eculizumab in a patient with factor-H-associated atypical hemolytic uremic syndrome. (21161283)
2011
18
Successful therapeutic plasma exchange in a 3.2-kg body weight neonate with atypical hemolytic uremic syndrome. (21322001)
2011
19
Atypical hemolytic uremic syndrome in the Tunisian population. (20499172)
2011
20
Acute renal replacement therapy in children with diarrhea-associated hemolytic uremic syndrome: a single center 16 years of experience. (21716936)
2011
21
Therapeutic plasma exchange in patients with thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: the 10-year experience of a single center. (21418736)
2011
22
Eculizumab safely reverses neurologic impairment and eliminates need for dialysis in severe atypical hemolytic uremic syndrome. (22287852)
2011
23
Outbreak of hemolytic-uremic syndrome linked to Shiga toxin-producing enteroaggregative Escherichia coli O104:H4. (21822097)
2011
24
Pregnancy-associated hemolytic uremic syndrome revisited in the era of complement gene mutations. (20203157)
2010
25
Shiga toxin-associated hemolytic uremic syndrome: pathophysiology of endothelial dysfunction. (20424866)
2010
26
Atypical hemolytic uremic syndrome and mutation analysis of factor H gene in two Tunisian families. (21694933)
2010
27
Treatment of typical (enteropathic) hemolytic uremic syndrome. (20865636)
2010
28
Atypical hemolytic uremic syndrome associated with mutations in complement regulator genes. (20865641)
2010
29
Triggering of atypical hemolytic uremic syndrome by influenza A (H1N1). (20540647)
2010
30
An outbreak of diarrhea-associated childhood hemolytic uremic syndrome: the Walkerton epidemic. (19180130)
2009
31
The thrombotic thrombocytopenic purpura and hemolytic uremic syndromes: overview of pathogenesis (Experience of The Oklahoma TTP-HUS Registry, 1989-2007). (19180141)
2009
32
Hemolytic uremic syndrome (HUS)--incidence and etiologies at a regional Children's Hospital in 2001-2006. (19685347)
2009
33
Clostridium septicum myonecrosis complicating diarrhea-associated hemolytic uremic syndrome. (18301926)
2008
34
Hemolytic uremic syndrome following Hemiscorpius lepturus (scorpion) sting. (20142930)
2008
35
Mutations in proteins of the alternative pathway of complement and the pathogenesis of atypical hemolytic uremic syndrome. (18423815)
2008
36
Pancreatitis preceding acute episodes of thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: report of five patients with a systematic review of published reports. (17606444)
2007
37
The interactive Factor H-atypical hemolytic uremic syndrome mutation database and website: update and integration of membrane cofactor protein and Factor I mutations with structural models. (17089378)
2007
38
Involvement of the fractalkine pathway in the pathogenesis of childhood hemolytic uremic syndrome. (17132725)
2007
39
The role of defective complement control in hemolytic uremic syndrome. (16575689)
2006
40
Role of fibroblast growth factor-binding protein in the pathogenesis of HIV-associated hemolytic uremic syndrome. (16352855)
2006
41
ADAMTS13, thrombotic thrombocytopenic purpura, and hemolytic uremic syndrome. (15865866)
2005
42
ADAMTS13 activity in thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: relation to presenting features and clinical outcomes in a prospective cohort of 142 patients. (12637323)
2003
43
Anticardiolipin antibodies in D+ hemolytic uremic syndrome. (12478355)
2002
44
Circulating inflammatory cytokine levels in hemolytic uremic syndrome. (10603133)
1999
45
Markers of thrombin generation in kidney failure of children with epidemic hemolytic uremic syndrome]. (9674202)
1998
46
Activation of both coagulation and fibrinolysis in childhood hemolytic uremic syndrome. (9767551)
1998
47
A 12-year-old boy with fatal hemolytic-uremic-syndrome, excessive neutrophilia and elevated endogenous granulocyte-colony-stimulating-factor serum concentrations. (9710348)
1998
48
Profiles of circulating inflammatory- and anti-inflammatory cytokines in patients with hemolytic uremic syndrome due to E. coli O157 infection. (9702419)
1998
49
Enterohemorrhagic Escherichia coli and hemolytic-uremic syndrome]. (9381722)
1997
50
Atypical Hemolytic-Uremic Syndrome (20301541)
1993

Variations for Hemolytic-Uremic Syndrome

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Expression for genes affiliated with Hemolytic-Uremic Syndrome

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hemolytic-Uremic Syndrome

Search GEO for disease gene expression data for Hemolytic-Uremic Syndrome.

Pathways for genes affiliated with Hemolytic-Uremic Syndrome

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50PathCards, 30KEGG, 38NCBI BioSystems Database, 53QIAGEN, 60Thomson Reuters, 55Reactome, 57SinoBiological
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Pathways related to Hemolytic-Uremic Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
18.7CFI, CFB, CFH
2
Show member pathways
Complement Activation, Classical Pathway38
Complement and Coagulation Cascades38
8.3CD46, CFI, CFB, CFH
3
Show member pathways
Immune response Alternative complement pathway60
Immune response Lectin Induced complement pathway60
Immune response Classic complement pathway60
7.6CD46, CFHR3, CFI, CFB, CFH
4
Show member pathways
7.6CFH, CFB, CFI, CFHR3, CD46

Compounds for genes affiliated with Hemolytic-Uremic Syndrome

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45Novoseek, 29IUPHAR, 24HMDB, 11DrugBank
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Compounds related to Hemolytic-Uremic Syndrome according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1sialic acid459.3CD46, CFH
2heparin45 29 24 1111.7CFHR1, CFI, CFH
3glucose458.7CFI, CFB, CFH
4serine458.2CFH, CFB, CFI, CD46

GO Terms for genes affiliated with Hemolytic-Uremic Syndrome

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16Gene Ontology
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Cellular components related to Hemolytic-Uremic Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.1CFHR1, CFHR3, CFI, CFH
2blood microparticleGO:0725628.1CFHR1, CFHR3, CFB, CFH

Biological processes related to Hemolytic-Uremic Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1complement activation, alternative pathwayGO:0069579.2CFB, CFH
2complement activation, classical pathwayGO:0069589.2CFI, CD46
3complement activationGO:0069569.0CFHR1, CFB, CFH
4regulation of complement activationGO:0304498.3CD46, CFH, CFB, CFI
5innate immune responseGO:0450878.2CFB, CFI, CD46, CFH

Molecular functions related to Hemolytic-Uremic Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1complement bindingGO:0018489.2CD46, CFB
2serine-type endopeptidase activityGO:0042529.1CFI, CFB

Products for genes affiliated with Hemolytic-Uremic Syndrome

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Sources for Hemolytic-Uremic Syndrome

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet