HUS
MCID: HML001
MIFTS: 54

Hemolytic-Uremic Syndrome (HUS) malady

Nephrological diseases, Blood diseases categories

Summaries for Hemolytic-Uremic Syndrome

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63Wikipedia, 32MalaCards
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Wikipedia:63 Hemolytic-uremic syndrome (or haemolytic-uraemic syndrome), abbreviated HUS, is a disease characterized... more...

MalaCards: Hemolytic-Uremic Syndrome, also known as hemolytic uremic syndrome, is related to atypical hemolytic-uremic syndrome and purpura. An important gene associated with Hemolytic-Uremic Syndrome is CFH (complement factor H), and among its related pathways are Activation of C3 and C5 and Classical Complement Pathway. The compounds cardiolipin and desmopressin have been mentioned in the context of this disorder. Affiliated tissues include kidney, endothelial and liver, and related mouse phenotypes are renal/urinary system and homeostasis/metabolism.

Aliases & Classifications for Hemolytic-Uremic Syndrome

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 42NIH Rare Diseases, 34MeSH, 39NCIt, 56SNOMED-CT, 27ICD9CM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases, Blood diseases


Aliases & Descriptions:

hemolytic-uremic syndrome 8 10 44 60
hemolytic uremic syndrome 8 42
acute renal failure, thrombocytopenia, and microangiopathic hemolytic anemia associated with distorted erythrocytes 42
hus 42


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Disease Ontology8 DOID:12554
MeSH34 D006463
NCIt39 C75545
ICD9CM27 283.11

Related Diseases for Hemolytic-Uremic Syndrome

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17GeneCards, 18GeneDecks
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Diseases in the Hemolytic-Uremic Syndrome family:

D-Plus Hemolytic Uremic Syndrome

Diseases related to Hemolytic-Uremic Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 234)
idRelated DiseaseScoreTop Affiliating Genes
1atypical hemolytic-uremic syndrome32.0CFHR1, CFHR3
2purpura31.5ADAMTS13
3complement deficiency30.8C3
4glomerulonephritis30.8CD46, CFI, CFH, C3
5leukemia30.6MSH2, CD46, MLH1
6membranoproliferative glomerulonephritis30.5C3, CFH, CD46
7disseminated intravascular coagulation30.5ADAMTS13, THBD
8hemolytic anemia30.5ADAMTS13, CFH, VWF
9hellp syndrome30.4VWF, ADAMTS13
10peritonitis30.4CFI
11arthritis30.2C3, SULT1A3
12hepatitis30.2CFB
13lupus erythematosus30.2THBD, C3
14hepatitis b30.2SULT1A3, CFB
15age related macular degeneration30.2C3, CFHR1, CFH, CFB, CFHR3
16antiphospholipid syndrome30.2VWF, CFH, THBD, SULT1A3, ADAMTS13
17connective tissue disease30.2VWF, THBD, C3
18nephrotic syndrome30.2CFI
19vascular disease30.2CD46, VWF, THBD, SULT1A3
20systemic lupus erythematosus30.2C4BPA, C4B, CD46, VWF, CFI, CFH
21meningitis30.2CFI, CD46
22diabetes mellitus30.2VWF, THBD, C3
23adenocarcinoma30.2MSH2, THBD, CD46, MLH1
24systemic scleroderma30.2CD46, VWF, THBD
25rheumatoid arthritis30.1CFI, CFB, C3
26myocardial infarction29.7VWF, CFH, SULT1A3, ADAMTS13
27acute myocardial infarction29.7VWF, THBD, SULT1A3, ADAMTS13
28transitional cell carcinoma29.7MSH2, THBD, MLH1
29thrombotic thrombocytopenic purpura11.0
30syndromic diarrhea10.8
31diarrhea10.8
32pneumonia10.8
33adult syndrome10.7
34pancreatitis10.5
35anuria10.5
36hypertension10.5
37influenza10.5
38hemolytic uremic syndrome, atypical 210.5
39hemolytic uremic syndrome, atypical, childhood10.5
40nephrosclerosis10.4
41shigellosis10.4
42acute leukemia10.4
43malignant hypertension10.4
44hemolytic uremic syndrome, atypical 310.4
45hemolytic uremic syndrome, atypical 410.4
46hemolytic uremic syndrome, atypical 510.4
47hemolytic uremic syndrome, atypical 610.4
48acute pancreatitis10.4
49acute diarrhea10.4
50cerebritis10.4

Graphical network of the top 20 diseases related to Hemolytic-Uremic Syndrome:



Diseases related to hemolytic-uremic syndrome

Clinical Features for Hemolytic-Uremic Syndrome

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Drugs & Therapeutics for Hemolytic-Uremic Syndrome

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Hemolytic-Uremic Syndrome

Drug clinical trials:

Search ClinicalTrials for Hemolytic-Uremic Syndrome

Search NIH Clinical Center for Hemolytic-Uremic Syndrome

Search CenterWatch for Hemolytic-Uremic Syndrome

Genetic Tests for Hemolytic-Uremic Syndrome

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Anatomical Context for Hemolytic-Uremic Syndrome

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32MalaCards
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MalaCards organs/tissues related to Hemolytic-Uremic Syndrome:

32
Kidney, Endothelial, Liver, Lung, Prostate, Monocytes, Testes, Skin, Pancreas, Heart, Bone, Bone marrow

Animal Models for Hemolytic-Uremic Syndrome or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Hemolytic-Uremic Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536710.4CFI, CFB, CFH, THBD, C3, C4B
2MP:00053769.9ADAMTS13, FHL1, C4B, MLH1, VWF, CFI

Publications for Hemolytic-Uremic Syndrome

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50PubMed
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Articles related to Hemolytic-Uremic Syndrome:

(show top 50)    (show all 688)
idTitleAuthorsYear
1
Hemolytic uremic syndrome. (24365375)
2014
2
Early infantile onset of atypical hemolytic-uremic syndrome is caused by recessive mutations in DGKE. (23875923)
2013
3
Adult hemolytic uremic syndrome associated with Streptococcus pneumoniae. (23380391)
2013
4
Ciprofloxacin reduces the risk of hemolytic uremic syndrome in patients with Escherichia coli O104:H4-associated diarrhea. (23292662)
2013
5
Profound neurological injury in a patient with atypical hemolytic uremic syndrome. (23139014)
2013
6
Distinct renal pathology and a chemotactic phenotype after enterohemorrhagic Escherichia coli shiga toxins in non-human primate models of hemolytic uremic syndrome. (23402998)
2013
7
Analysis of genetic and predisposing factors in Japanese patients with atypical hemolytic uremic syndrome. (23314101)
2013
8
A newly identified mutation in the complement factor I gene not associated with early post-transplant recurrence of atypical hemolytic-uremic syndrome: a case report. (24034049)
2013
9
Resolution of ocular involvement with systemic eculizumab therapy in atypical hemolytic-uremic syndrome. (23722719)
2013
10
Interventions for preventing diarrhea-associated hemolytic uremic syndrome: systematic review. (24007265)
2013
11
Posttransplant recurrence of atypical hemolytic uremic syndrome. (22760880)
2012
12
Atypical hemolytic uremic syndrome in children: complement mutations and clinical characteristics. (22410797)
2012
13
Severe pneumococcal hemolytic uremic syndrome in an 8-month-old girl. (22982916)
2012
14
Need for long-term follow-up in enterohemorrhagic Escherichia coli-associated hemolytic uremic syndrome due to late-emerging sequelae. (22412065)
2012
15
C1q nephropathy with acute hemolytic uremic syndrome. (22569444)
2012
16
Keeping the heart in mind when managing hemolytic: uremic syndrome. (21838193)
2011
17
Diarrhea-associated hemolytic uremic syndrome in southern Alberta: A long-term single-centre experience. (22654544)
2011
18
Antibody response to Shiga toxins in Argentinean children with enteropathic hemolytic uremic syndrome at acute and long-term follow-up periods. (21559455)
2011
19
Hemolytic uremic syndrome and rhabdomyolysis in a patient with succinate coenzyme Q reductase (complex II) deficiency. (21722608)
2011
20
Mitomycin--C-induced thrombotic thrombocytopenic purpura/hemolytic uremic syndrome: cumulative toxicity of an old drug in a new era. (21859568)
2011
21
An adult case of combined encephalopathy and hemolytic uremic syndrome caused by Escherichia coli O157. (21212597)
2011
22
Different factor H-related protein patterns in siblings with typical hemolytic uremic syndrome. (21505959)
2011
23
Pregnancy-associated hemolytic uremic syndrome revisited in the era of complement gene mutations. (20203157)
2010
24
Atypical hemolytic uremic syndrome and mutation analysis of factor H gene in two Tunisian families. (21694933)
2010
25
Treatment of typical (enteropathic) hemolytic uremic syndrome. (20865636)
2010
26
Relapsing or refractory idiopathic thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: the role of rituximab. (20576013)
2010
27
Thrombotic microangiopathies: thrombotic thrombocytopenic purpura / hemolytic uremic syndrome. (21103695)
2010
28
More on eculizumab for congenital atypical hemolytic-uremic syndrome. (19439754)
2009
29
Risk factors for neurological complications in complete hemolytic uremic syndrome caused by Escherichia coli O157. (19405919)
2009
30
Recurrent atypical hemolytic uremic syndrome associated with factor I mutation in a living related renal transplant recipient. (18805611)
2009
31
Clinicopathological characteristics and outcome of Chinese patients with thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: a 9-year retrospective study. (19439988)
2009
32
Hemolytic uremic syndrome as a primary manifestation of acute human immunodeficiency virus infection. (19473618)
2009
33
Development of an experimental hemolytic uremic syndrome in rats. (18253762)
2008
34
Membrane cofactor protein mutations in atypical hemolytic uremic syndrome (aHUS), fatal Stx-HUS, C3 glomerulonephritis, and the HELLP syndrome. (17914026)
2008
35
Role of polymorphonuclear leukocytes in the pathophysiology of typical hemolytic uremic syndrome. (17694250)
2007
36
Hemolytic uremic syndrome]. (17342690)
2007
37
Gastrointestinal complications of post-diarrheal hemolytic uremic syndrome. (17968789)
2007
38
Endemic Esherichia coil O157:H7 infections and hemolytic-uremic syndrome in Oklahoma, 2002-2005. (18183860)
2007
39
Phenotypic expression of factor H mutations in patients with atypical hemolytic uremic syndrome. (16528247)
2006
40
Complement factor H-associated atypical hemolytic uremic syndrome in monozygotic twins: concordant presentation, discordant response to treatment. (16431247)
2006
41
A case of atypical hemolytic uremic syndrome with a transient decrease in complement factor H. (16362720)
2006
42
Two novel ADAMTS13 gene mutations in thrombotic thrombocytopenic purpura/hemolytic-uremic syndrome (TTP/HUS). (15327386)
2004
43
Acute leukemia: an association with atypical hemolytic uremic syndrome. (12750987)
2003
44
Molecular basis of familial thrombotic thrombocytopenic purpura and hemolytic uremic syndrome. (17657106)
2003
45
Anticardiolipin antibodies in D+ hemolytic uremic syndrome. (12478355)
2002
46
Secondary membranoproliferative glomerulonephritis due to hemolytic uremic syndrome: an unusual presentation. (9834983)
1998
47
Low levels of serum erythropoietin in children with endemic hemolytic uremic syndrome. (9630043)
1998
48
Diarrhea-associated hemolytic-uremic syndrome in a child with nail-patella syndrome. (7597489)
1995
49
Hemolytic uremic syndrome associated with shigellosis: report of two cases. (3313740)
1987
50
Risk factors for development of hemolytic uremic syndrome during shigellosis. (3295160)
1987

Genetic Variations for Hemolytic-Uremic Syndrome

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Expression for genes affiliated with Hemolytic-Uremic Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hemolytic-Uremic Syndrome

Search GEO for disease gene expression data for Hemolytic-Uremic Syndrome.

Pathways for genes affiliated with Hemolytic-Uremic Syndrome

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53Reactome, 51QIAGEN, 37NCBI BioSystems Database, 55SinoBiological, 29KEGG, 12EMD Millipore
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Compounds for genes affiliated with Hemolytic-Uremic Syndrome

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44Novoseek, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 49PharmGKB, 24HMDB
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Compounds related to Hemolytic-Uremic Syndrome according to GeneCards/GeneDecks:

(show all 32)
idCompoundScoreTop Affiliating Genes
1cardiolipin44 1111.8CFH
2desmopressin44 59 28 1113.8VWF, THBD, ADAMTS13
3nacl4410.8CFI, CFH, THBD, SULT1A3, ADAMTS13
4serine4410.8C4BPB, CD46, MSH2, C3, ADAMTS13
5cyclophosphamide44 49 1112.7ADAMTS13, THBD, VWF, CD46
6carbohydrates4410.7THBD, CFI, VWF, C4B
7agarose4410.7C4B, MLH1, VWF, CFB, THBD, C3
8beraprost sodium4410.7VWF, THBD
9creatinine4410.7VWF, CFI, THBD, SULT1A3, C3, ADAMTS13
10cholesterol44 28 11 2413.7C4BPA, VWF, CFI, CFH, THBD, SULT1A3
11fibrinogen4410.7C4BPA, VWF, CFI, CFH, THBD, SULT1A3
12cyclosporin a44 28 5912.7CD46, VWF, CFH, THBD, ADAMTS13
13kininogen4410.7THBD, CFI, VWF
14paraffin4410.7MLH1, CD46, VWF, THBD, MSH2
15n-methyl-n-nitrosourea4410.7MSH2, MLH1
16alanine4410.7C4BPB, MLH1, CD46, VWF, CFH, THBD
17dexamethasone44 49 28 1113.7CD46, VWF, CFH, THBD, SULT1A3, C3
18aspirin44 49 28 2413.7SULT1A3, THBD, VWF, MLH1
19Intravenous Immunoglobulin1110.7C3, C4B
20steroid4410.7ADAMTS13, C3, SULT1A3, THBD, MLH1, C4B
21heparin44 28 11 2413.7ADAMTS13, C4BPA, C4BPB, CFHR4, CFI, CFHR2
22methionine4410.6MLH1, VWF, CFI, THBD
23polysaccharide4410.6CD46, CFH, THBD, C3
24estrogen4410.6MLH1, VWF, CFI, THBD, SULT1A3, C3
2511-dehydrothromboxane b24410.6THBD, VWF
26progesterone44 59 28 11 2414.6C3, SULT1A3, THBD, CD46, MLH1
27phospholipid4410.5C3, THBD, VWF, C4BPB
28biotin44 11 2412.5MLH1, VWF, MSH2
29homocysteine44 2411.4SULT1A3, THBD, VWF
306-ketoprostaglandin f1alpha4410.3VWF, THBD
31calcium44 49 11 2413.3C4BPB, C4B, MLH1, CD46, VWF, CFI
32mononucleotide4410.1MLH1, MSH2

GO Terms for genes affiliated with Hemolytic-Uremic Syndrome

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16Gene Ontology
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Cellular components related to Hemolytic-Uremic Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.4CFHR3, CFI, CFH, CFHR1, C3, ADAMTS13
2extracellular regionGO:0055769.9C3, C4BPA, C4BPB, C4B, VWF, CFHR4

Biological processes related to Hemolytic-Uremic Syndrome according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1regulation of complement activationGO:03044910.5C3, C4BPA, C4BPB, C4B, CD46, CFI
2complement activationGO:00695610.5C4B, CFB, CFH, CFHR1, C3
3complement activation, classical pathwayGO:00695810.5C4BPA, C4BPB, C4B, CD46, CFI, C3
4isotype switchingGO:04519010.4MSH2, MLH1
5complement activation, alternative pathwayGO:00695710.4CFB, CFH, CFHR5, C3
6innate immune responseGO:04508710.2C4BPA, C4BPB, C4B, CD46, CFI, CFB
7somatic hypermutation of immunoglobulin genesGO:01644610.1MSH2, MLH1

Molecular functions related to Hemolytic-Uremic Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1guanine/thymine mispair bindingGO:03213710.4MSH2, MLH1
2complement bindingGO:00184810.1CFB, CD46

Products for genes affiliated with Hemolytic-Uremic Syndrome

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Sources for Hemolytic-Uremic Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet