MCID: HML001
MIFTS: 43

Hemolytic-Uremic Syndrome malady

Rare diseases, Immune diseases, Blood diseases, Nephrological diseases categories

Aliases & Classifications for Hemolytic-Uremic Syndrome

About this section

Hemolytic-Uremic Syndrome, Aliases & Descriptions:

Name: Hemolytic-Uremic Syndrome 9 11 43 60
Hemolytic Uremic Syndrome 9 41
Acute Renal Failure, Thrombocytopenia, and Microangiopathic Hemolytic Anemia Associated with Distorted Erythrocytes 41
 
Haemolytic-Uraemic Syndrome 9
Hus 41


Classifications:



External Ids:

Disease Ontology9 DOID:12554
NCIt38 C75545
ICD9CM27 283.11
MeSH33 D006463
ICD1025 D59.3

Summaries for Hemolytic-Uremic Syndrome

About this section


NIH Rare Diseases:41 Hemolytic uremic syndrome (hus) is a disorder that usually occurs when an  e. coli bacterial infection in the digestive system produces toxic substances that destroy red blood cells. symptoms include vomiting and diarrhea, fever, lethargy, and weakness. in severe cases it can lead to kidney failure or death. while this condition is most common in children, it often has a more complicated presentation in adults. treatment may include dialysis, corticosteroids, transfusions of packed red blood cells and plasmapheresis.   hemolytic uremic syndrome should be distinguished from atypical hemolytic uremic syndrome (ahus). the two conditions have different causes and different signs and symptoms. last updated: 1/3/2015

MalaCards based summary: Hemolytic-Uremic Syndrome, also known as hemolytic uremic syndrome, is related to thrombotic thrombocytopenic purpura and hemolytic uremic syndrome, atypical 1. An important gene associated with Hemolytic-Uremic Syndrome is CFH (complement factor H), and among its related pathways are Staphylococcus aureus infection and Complement and coagulation cascades. The compounds sialic acid and heparin have been mentioned in the context of this disorder. Affiliated tissues include kidney, endothelial and liver, and related mouse phenotype renal/urinary system.

Wikipedia:63 Hemolytic-uremic syndrome (or haemolytic-uraemic syndrome), abbreviated HUS, is a disease characterized... more...

Related Diseases for Hemolytic-Uremic Syndrome

About this section

Diseases in the Hemolytic-Uremic Syndrome family:

D-Plus Hemolytic Uremic Syndrome

Diseases related to Hemolytic-Uremic Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 220)
idRelated DiseaseScoreTop Affiliating Genes
1thrombotic thrombocytopenic purpura31.8CD46, CFH
2hemolytic uremic syndrome, atypical 131.6CFHR1, CFHR3
3complement factor h deficiency31.5CFH
4membranoproliferative glomerulonephritis30.8CFH, CD46
5glomerulonephritis30.7CD46, CFI, CFH
6thrombocytopenia30.6CD46, CFH
7meningitis30.1CFI, CD46
8nephritis30.0CFI, CFB
9systemic lupus erythematosus29.9CD46, CFI, CFH
10purpura11.1
11diarrhea10.9
12pneumonia10.8
13endotheliitis10.7
14typical hemolytic-uremic syndrome10.7
15pancreatitis10.6
16anuria10.6
17influenza10.6
18hemolytic uremic syndrome, atypical, childhood10.6
19hemolytic uremic syndrome, atypical 210.5
20hemolytic uremic syndrome, atypical 310.5
21hemolytic uremic syndrome, atypical 410.5
22hemolytic uremic syndrome, atypical 510.5
23hemolytic uremic syndrome, atypical 610.5
24colitis10.5
25malaria10.5
26leukemia10.5
27nephrosclerosis10.5
28shigellosis10.5
29malignant hypertension10.5
30d-minus hemolytic uremic syndrome10.5
31d-plus hemolytic uremic syndrome10.5
32atypical hemolytic-uremic syndrome with thrombomodulin anomaly10.5
33atypical hemolytic-uremic syndrome with dgke deficiency10.5
34atypical hemolytic-uremic syndrome with b factor anomaly10.5
35atypical hemolytic-uremic syndrome with h factor anomaly10.5
36atypical hemolytic-uremic syndrome with c3 anomaly10.5
37atypical hemolytic-uremic syndrome with mcp/cd46 anomaly10.5
38atypical hemolytic-uremic syndrome with i factor anomaly10.5
39atypical hemolytic-uremic syndrome with anti-factor h antibodies10.5
40plasmodium vivax malaria10.4
41cerebritis10.4
42disseminated intravascular coagulation10.4
43peritonitis10.4
44pertussis10.4
45cd46-related atypical hemolytic-uremic syndrome10.4
46cfb-related atypical hemolytic-uremic syndrome10.4
47cfh-related atypical hemolytic-uremic syndrome10.4
48cfi-related atypical hemolytic-uremic syndrome10.4
49thbd-related atypical hemolytic-uremic syndrome10.4
50cfhr3 and cfhr1-related atypical hemolytic-uremic syndrome10.4

Graphical network of the top 20 diseases related to Hemolytic-Uremic Syndrome:



Diseases related to hemolytic-uremic syndrome

Symptoms for Hemolytic-Uremic Syndrome

About this section

Drugs & Therapeutics for Hemolytic-Uremic Syndrome

About this section

Drug clinical trials:

Search ClinicalTrials for Hemolytic-Uremic Syndrome

Search NIH Clinical Center for Hemolytic-Uremic Syndrome

Genetic Tests for Hemolytic-Uremic Syndrome

About this section

Anatomical Context for Hemolytic-Uremic Syndrome

About this section

MalaCards organs/tissues related to Hemolytic-Uremic Syndrome:

31
Kidney, Endothelial, Liver, Lung, Heart, Skin, Prostate, Testes, Monocytes, Bone marrow, Bone, Brain, Pancreas

Animal Models for Hemolytic-Uremic Syndrome or affiliated genes

About this section

MGI Mouse Phenotypes related to Hemolytic-Uremic Syndrome:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.7CFI, CFB, CFH

Publications for Hemolytic-Uremic Syndrome

About this section

Articles related to Hemolytic-Uremic Syndrome:

(show top 50)    (show all 736)
idTitleAuthorsYear
1
Hemolytic Uremic Syndrome is associated with dysregulation of Chemokine Receptor expression in Circulating Monocytes. (25748554)
2015
2
Role of the skin biopsy in the diagnosis of atypical hemolytic uremic syndrome. (25893747)
2015
3
Atypical hemolytic uremic syndrome: the role of complement pathway gene mutation analysis. (25003358)
2014
4
Clinical and epidemiological peculiarities of hemorrhagic colitis complicated by hemolytic-uremic syndrome. (25341242)
2014
5
Eculizumab in the treatment of atypical hemolytic uremic syndrome in an infant leads to cessation of peritoneal dialysis and improvement of severe hypertension. (25318620)
2014
6
Atypical Hemolytic Uremic Syndrome: Differential Diagnosis from TTP/HUS and Management. (25319590)
2014
7
Enterohemorrhagic Escherichia coli Infections and the Hemolytic-Uremic Syndrome. (23809720)
2013
8
Hemolytic uremic syndrome related to cryptosporidium infection in an immunocompetent child. (24330289)
2013
9
Multifaceted hemolytic uremic syndrome in pediatrics. (23343552)
2013
10
Untying the knot of thrombotic thrombocytopenic purpura and atypical hemolytic uremic syndrome. (23410558)
2013
11
Eculizumab in atypical hemolytic-uremic syndrome. (24088108)
2013
12
Early infantile onset of atypical hemolytic-uremic syndrome is caused by recessive mutations in DGKE. (23875923)
2013
13
Adult hemolytic uremic syndrome associated with Streptococcus pneumoniae. (23380391)
2013
14
Factor I autoantibodies in patients with atypical hemolytic uremic syndrome: disease-associated or an epiphenomenon? (22223611)
2012
15
Interpretation of genetic variants of uncertain significance in atypical hemolytic uremic syndrome. (22170528)
2012
16
Complement factor H variants I890 and L1007 while commonly associated with atypical hemolytic uremic syndrome are polymorphisms with no functional significance. (21881555)
2012
17
Atypical hemolytic uremic syndrome-associated variants and autoantibodies impair binding of factor h and factor h-related protein 1 to pentraxin 3. (22786770)
2012
18
Hemorrhagic colitis in postdiarrheal hemolytic uremic syndrome: retrospective analysis of 54 children. (21809003)
2012
19
Eculizumab therapy in a child with hemolytic uremic syndrome and CFI mutation. (22903728)
2012
20
Severe Bordetella pertussis infection associated with hemolytic uremic syndrome. (22953627)
2012
21
Efficacy of eculizumab in a patient with factor-H-associated atypical hemolytic uremic syndrome. (21161283)
2011
22
Successful therapeutic plasma exchange in a 3.2-kg body weight neonate with atypical hemolytic uremic syndrome. (21322001)
2011
23
Acute renal replacement therapy in children with diarrhea-associated hemolytic uremic syndrome: a single center 16 years of experience. (21716936)
2011
24
Therapeutic plasma exchange in patients with thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: the 10-year experience of a single center. (21418736)
2011
25
Pregnancy-associated hemolytic uremic syndrome revisited in the era of complement gene mutations. (20203157)
2010
26
Shiga toxin-associated hemolytic uremic syndrome: pathophysiology of endothelial dysfunction. (20424866)
2010
27
Atypical hemolytic uremic syndrome and mutation analysis of factor H gene in two Tunisian families. (21694933)
2010
28
Treatment of typical (enteropathic) hemolytic uremic syndrome. (20865636)
2010
29
Atypical hemolytic uremic syndrome associated with mutations in complement regulator genes. (20865641)
2010
30
Triggering of atypical hemolytic uremic syndrome by influenza A (H1N1). (20540647)
2010
31
An outbreak of diarrhea-associated childhood hemolytic uremic syndrome: the Walkerton epidemic. (19180130)
2009
32
The thrombotic thrombocytopenic purpura and hemolytic uremic syndromes: overview of pathogenesis (Experience of The Oklahoma TTP-HUS Registry, 1989-2007). (19180141)
2009
33
Clostridium septicum myonecrosis complicating diarrhea-associated hemolytic uremic syndrome. (18301926)
2008
34
Hemolytic uremic syndrome following Hemiscorpius lepturus (scorpion) sting. (20142930)
2008
35
Mutations in proteins of the alternative pathway of complement and the pathogenesis of atypical hemolytic uremic syndrome. (18423815)
2008
36
Pancreatitis preceding acute episodes of thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: report of five patients with a systematic review of published reports. (17606444)
2007
37
The interactive Factor H-atypical hemolytic uremic syndrome mutation database and website: update and integration of membrane cofactor protein and Factor I mutations with structural models. (17089378)
2007
38
Involvement of the fractalkine pathway in the pathogenesis of childhood hemolytic uremic syndrome. (17132725)
2007
39
The role of defective complement control in hemolytic uremic syndrome. (16575689)
2006
40
Role of fibroblast growth factor-binding protein in the pathogenesis of HIV-associated hemolytic uremic syndrome. (16352855)
2006
41
ADAMTS13, thrombotic thrombocytopenic purpura, and hemolytic uremic syndrome. (15865866)
2005
42
ADAMTS13 activity in thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: relation to presenting features and clinical outcomes in a prospective cohort of 142 patients. (12637323)
2003
43
Anticardiolipin antibodies in D+ hemolytic uremic syndrome. (12478355)
2002
44
Circulating inflammatory cytokine levels in hemolytic uremic syndrome. (10603133)
1999
45
Markers of thrombin generation in kidney failure of children with epidemic hemolytic uremic syndrome]. (9674202)
1998
46
Activation of both coagulation and fibrinolysis in childhood hemolytic uremic syndrome. (9767551)
1998
47
A 12-year-old boy with fatal hemolytic-uremic-syndrome, excessive neutrophilia and elevated endogenous granulocyte-colony-stimulating-factor serum concentrations. (9710348)
1998
48
Profiles of circulating inflammatory- and anti-inflammatory cytokines in patients with hemolytic uremic syndrome due to E. coli O157 infection. (9702419)
1998
49
Enterohemorrhagic Escherichia coli and hemolytic-uremic syndrome]. (9381722)
1997
50
Atypical Hemolytic-Uremic Syndrome (20301541)
1993

Variations for Hemolytic-Uremic Syndrome

About this section

Expression for genes affiliated with Hemolytic-Uremic Syndrome

About this section
Search GEO for disease gene expression data for Hemolytic-Uremic Syndrome.

Pathways for genes affiliated with Hemolytic-Uremic Syndrome

About this section

Pathways related to Hemolytic-Uremic Syndrome according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
18.7CFI, CFB, CFH
2
Show member pathways
Complement Activation, Classical Pathway36
Complement and Coagulation Cascades36
8.3CD46, CFI, CFB, CFH
3
Show member pathways
Immune response Alternative complement pathway58
Immune response Lectin Induced complement pathway58
Immune response Classic complement pathway58
7.6CD46, CFHR3, CFI, CFB, CFH
4
Show member pathways
7.6CFH, CFB, CFI, CFHR3, CD46

Compounds for genes affiliated with Hemolytic-Uremic Syndrome

About this section
Sources:
43Novoseek, 28IUPHAR, 24HMDB, 12DrugBank
See all sources

Compounds related to Hemolytic-Uremic Syndrome according to GeneCards Suite gene sharing:

idCompoundScoreTop Affiliating Genes
1sialic acid439.3CD46, CFH
2heparin43 28 24 1211.7CFHR1, CFI, CFH
3glucose438.7CFI, CFB, CFH
4serine438.2CFH, CFB, CFI, CD46

GO Terms for genes affiliated with Hemolytic-Uremic Syndrome

About this section

Cellular components related to Hemolytic-Uremic Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.1CFHR1, CFHR3, CFI, CFH
2blood microparticleGO:00725628.1CFHR1, CFHR3, CFB, CFH

Biological processes related to Hemolytic-Uremic Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1complement activation, alternative pathwayGO:00069579.2CFB, CFH
2complement activation, classical pathwayGO:00069589.2CD46, CFI
3complement activationGO:00069569.0CFHR1, CFB, CFH
4regulation of complement activationGO:00304498.3CD46, CFI, CFB, CFH
5innate immune responseGO:00450878.2CFH, CFB, CFI, CD46

Molecular functions related to Hemolytic-Uremic Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1complement bindingGO:00018489.2CD46, CFB
2serine-type endopeptidase activityGO:00042529.1CFI, CFB

Products for genes affiliated with Hemolytic-Uremic Syndrome

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Hemolytic-Uremic Syndrome

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet