Hemolytic-Uremic Syndrome disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Hemolytic-Uremic Syndrome

Sources:
⁶⁴Wikipedia, ³²MalaCards
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Wikipedia:⁶⁴ Hemolytic-uremic syndrome (or haemolytic-uraemic syndrome), abbreviated HUS, is a disease characterized... more...

MalaCards based summary: Hemolytic-Uremic Syndrome, also known as hemolytic uremic syndrome, is related to atypical hemolytic-uremic syndrome and complement factor h deficiency. An important gene associated with Hemolytic-Uremic Syndrome is CFH (complement factor H), and among its related pathways are Staphylococcus aureus infection and Complement and coagulation cascades. The compounds sialic acid and heparin have been mentioned in the context of this disorder. Affiliated tissues include kidney, endothelial and liver, and related mouse phenotype renal/urinary system.

Aliases & Classifications for Hemolytic-Uremic Syndrome

Sources:
⁹Disease Ontology, ⁴²NIH Rare Diseases, ¹¹DISEASES, ⁴⁴Novoseek, ⁶¹UMLS, ⁵⁶SNOMED-CT, ²⁸ICD9CM, ³⁹NCIt, ³⁴MeSH
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Hemolytic-Uremic Syndrome, Aliases & Descriptions:

Name: Hemolytic-Uremic Syndrome ⁹ ¹¹ ⁴⁴ ⁶¹

Hemolytic Uremic Syndrome ⁹ ⁴²

Acute Renal Failure, Thrombocytopenia, and Microangiopathic Hemolytic Anemia Associated with Distorted Erythrocytes ⁴²

Hus ⁴²

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Blood diseases, Nephrological diseases

External Ids:

Disease Ontology⁹ DOID:12554

ICD9CM²⁸ 283.11

SNOMED-CT⁵⁶ 123308008, 111407006

NCIt³⁹ C75545

MeSH³⁴ D006463

UMLS⁶¹ C0019061

Related Diseases for Hemolytic-Uremic Syndrome

Sources:
¹⁸GeneCards, ¹⁹GeneDecks
See all sources

Diseases in the Hemolytic-Uremic Syndrome family:

D-Plus Hemolytic Uremic Syndrome

Diseases related to Hemolytic-Uremic Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50) (show all 210)

id	Related Disease	Score	Top Affiliating Genes
1	atypical hemolytic-uremic syndrome	32.2	CFHR1, CFHR3
2	complement factor h deficiency	31.4	CFH
3	membranoproliferative glomerulonephritis	30.9	CFH, CD46
4	glomerulonephritis	30.7	CD46, CFI, CFH
5	thrombocytopenia	30.6	CD46, CFH
6	meningitis	30.1	CFI, CD46
7	systemic lupus erythematosus	29.9	CD46, CFI, CFH
8	age related macular degeneration	29.8	CFH, CFB, CFHR3, CFHR1
9	purpura	11.1
10	thrombotic thrombocytopenic purpura	11.1
11	diarrhea	10.9
12	pneumonia	10.8
13	endotheliitis	10.7
14	hypertension	10.6
15	pancreatitis	10.6
16	anuria	10.6
17	influenza	10.6
18	colitis	10.5
19	hemolytic uremic syndrome, atypical, childhood	10.5
20	leukemia	10.5
21	malaria	10.5
22	nephrosclerosis	10.5
23	shigellosis	10.5
24	malignant hypertension	10.5
25	hemolytic uremic syndrome, atypical 2	10.5
26	hemolytic uremic syndrome, atypical 3	10.5
27	hemolytic uremic syndrome, atypical 4	10.5
28	hemolytic uremic syndrome, atypical 5	10.5
29	hemolytic uremic syndrome, atypical 6	10.5
30	plasmodium vivax malaria	10.4
31	cerebritis	10.4
32	disseminated intravascular coagulation	10.4
33	peritonitis	10.4
34	pertussis	10.4
35	d-minus hemolytic uremic syndrome	10.4
36	d-plus hemolytic uremic syndrome	10.4
37	retinal drusen	10.4	CFH
38	neuronitis	10.4
39	crohn's disease	10.3
40	prostate cancer	10.3
41	retinal vein occlusion	10.3
42	acute pancreatitis	10.3
43	central retinal vein occlusion	10.3
44	hyperuricemia	10.3
45	crescentic glomerulonephritis	10.3
46	hellp syndrome	10.3
47	emphysematous cholecystitis	10.3
48	cholecystitis	10.3
49	dysentery	10.3
50	intestinal perforation	10.3

Graphical network of the top 20 diseases related to Hemolytic-Uremic Syndrome:

Symptoms for Hemolytic-Uremic Syndrome

Drugs & Therapeutics for Hemolytic-Uremic Syndrome

Sources:
⁴¹NIH Clinical Center, ⁶ClinicalTrials, ⁶¹UMLS, ⁴⁰NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Hemolytic-Uremic Syndrome

Search NIH Clinical Center for Hemolytic-Uremic Syndrome

Genetic Tests for Hemolytic-Uremic Syndrome

Anatomical Context for Hemolytic-Uremic Syndrome

Sources:
³²MalaCards
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MalaCards organs/tissues related to Hemolytic-Uremic Syndrome:

³²

Kidney, Endothelial, Liver, Lung, Prostate, Bone marrow, Bone, Heart, Pancreas, Skin, Testes, Monocytes

Animal Models for Hemolytic-Uremic Syndrome or affiliated genes

Sources:
³⁶MGI
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MGI Mouse Phenotypes related to Hemolytic-Uremic Syndrome:

³⁶

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	renal/urinary system phenotype	MP:0005367	8.7	CFI, CFB, CFH

Publications for Hemolytic-Uremic Syndrome

Sources:
⁵¹PubMed
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Articles related to Hemolytic-Uremic Syndrome:

(show top 50) (show all 714)

id	Title	Authors	Year
1	Atypical hemolytic uremic syndrome: the role of complement pathway gene mutation analysis. (25003358)	Weitz I.C.	2014
2	Clinical and epidemiological peculiarities of hemorrhagic colitis complicated by hemolytic-uremic syndrome. (25341242)	Pachkoria E.... Tevzadze L.	2014
3	Natural History of Thrombotic Thrombocytopenic Purpura and Hemolytic Uremic Syndrome. (25377323)	Wada H.... Yamashita Y.	2014
4	Eculizumab in the treatment of atypical hemolytic uremic syndrome in an infant leads to cessation of peritoneal dialysis and improvement of severe hypertension. (25318620)	Ohta T.... Fujimura Y.	2014
5	Atypical Hemolytic Uremic Syndrome: Differential Diagnosis from TTP/HUS and Management. (25319590)	Yenerel M.N.	2014
6	Enterohemorrhagic Escherichia coli Infections and the Hemolytic-Uremic Syndrome. (23809720)	Page A.V.... Liles W.C.	2013
7	Hemolytic uremic syndrome related to cryptosporidium infection in an immunocompetent child. (24330289)	Printza N.... Papachristou F.	2013
8	Multifaceted hemolytic uremic syndrome in pediatrics. (23343552)	Nester C.M.	2013
9	Untying the knot of thrombotic thrombocytopenic purpura and atypical hemolytic uremic syndrome. (23410558)	Tsai H.M.	2013
10	Eculizumab in atypical hemolytic-uremic syndrome. (24088108)	Kistler A.D.	2013
11	Early infantile onset of atypical hemolytic-uremic syndrome is caused by recessive mutations in DGKE. (23875923)	Lee J.W.	2013
12	Adult hemolytic uremic syndrome associated with Streptococcus pneumoniae. (23380391)	Allen J.C.... Kolhe N.V.	2013
13	Factor I autoantibodies in patients with atypical hemolytic uremic syndrome: disease-associated or an epiphenomenon? (22223611)	Kavanagh D.... Marchbank K.J.	2012
14	Interpretation of genetic variants of uncertain significance in atypical hemolytic uremic syndrome. (22170528)	Kavanagh D.... Anderson H.E.	2012
15	Complement factor H variants I890 and L1007 while commonly associated with atypical hemolytic uremic syndrome are polymorphisms with no functional significance. (21881555)	Tortajada A.... de CA^rdoba S.R.	2012
16	Atypical hemolytic uremic syndrome-associated variants and autoantibodies impair binding of factor h and factor h-related protein 1 to pentraxin 3. (22786770)	Kopp A.... JA^zsi M.	2012
17	Hemorrhagic colitis in postdiarrheal hemolytic uremic syndrome: retrospective analysis of 54 children. (21809003)	Rahman R.C.... Gatti M.C.	2012
18	Eculizumab therapy in a child with hemolytic uremic syndrome and CFI mutation. (22903728)	Cayci F.S.... Gur G.	2012
19	Severe Bordetella pertussis infection associated with hemolytic uremic syndrome. (22953627)	Cohen-Ganelin E.... Prais D.	2012
20	Efficacy of eculizumab in a patient with factor-H-associated atypical hemolytic uremic syndrome. (21161283)	Lapeyraque A.L.... Robitaille P.	2011
21	Successful therapeutic plasma exchange in a 3.2-kg body weight neonate with atypical hemolytic uremic syndrome. (21322001)	Jung S.... Chang Y.S.	2011
22	Atypical hemolytic uremic syndrome in the Tunisian population. (20499172)	Leban N.... Haj Khelil A.	2011
23	Acute renal replacement therapy in children with diarrhea-associated hemolytic uremic syndrome: a single center 16 years of experience. (21716936)	Grisaru S.... Hamiwka L.A.	2011
24	Therapeutic plasma exchange in patients with thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: the 10-year experience of a single center. (21418736)	Kim J.W.... Kim B.K.	2011
25	Pregnancy-associated hemolytic uremic syndrome revisited in the era of complement gene mutations. (20203157)	Fakhouri F.... FrAcmeaux-Bacchi V.	2010
26	Shiga toxin-associated hemolytic uremic syndrome: pathophysiology of endothelial dysfunction. (20424866)	Zoja C.... Morigi M.	2010
27	Atypical hemolytic uremic syndrome and mutation analysis of factor H gene in two Tunisian families. (21694933)	Habibi I.... Gorgi Y.	2010
28	Treatment of typical (enteropathic) hemolytic uremic syndrome. (20865636)	Bitzan M.... Reymond D.	2010
29	Atypical hemolytic uremic syndrome associated with mutations in complement regulator genes. (20865641)	Le Quintrec M.... FrAcmeaux-Bacchi V.	2010
30	Triggering of atypical hemolytic uremic syndrome by influenza A (H1N1). (20540647)	Bento D.... Meneses-Oliveira C.	2010
31	An outbreak of diarrhea-associated childhood hemolytic uremic syndrome: the Walkerton epidemic. (19180130)	Matsell D.G.... White C.T.	2009
32	The thrombotic thrombocytopenic purpura and hemolytic uremic syndromes: overview of pathogenesis (Experience of The Oklahoma TTP-HUS Registry, 1989-2007). (19180141)	George J.N.	2009
33	Clostridium septicum myonecrosis complicating diarrhea-associated hemolytic uremic syndrome. (18301926)	Hunley T.E.... Jabs K.	2008
34	Hemolytic uremic syndrome following Hemiscorpius lepturus (scorpion) sting. (20142930)	Valavi E.... Ansari M.J.	2008
35	Mutations in proteins of the alternative pathway of complement and the pathogenesis of atypical hemolytic uremic syndrome. (18423815)	Abarrategui-Garrido C.... SA!nchez-Corral P.	2008
36	Pancreatitis preceding acute episodes of thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: report of five patients with a systematic review of published reports. (17606444)	Swisher K.K.... George J.N.	2007
37	The interactive Factor H-atypical hemolytic uremic syndrome mutation database and website: update and integration of membrane cofactor protein and Factor I mutations with structural models. (17089378)	Saunders R.E.... Perkins S.J.	2007
38	Involvement of the fractalkine pathway in the pathogenesis of childhood hemolytic uremic syndrome. (17132725)	Ramos M.V.... Palermo M.S.	2007
39	The role of defective complement control in hemolytic uremic syndrome. (16575689)	Zipfel P.F.... Skerka C.	2006
40	Role of fibroblast growth factor-binding protein in the pathogenesis of HIV-associated hemolytic uremic syndrome. (16352855)	Ray P.E.... Wellstein A.	2006
41	ADAMTS13, thrombotic thrombocytopenic purpura, and hemolytic uremic syndrome. (15865866)	George J.N.	2005
42	ADAMTS13 activity in thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: relation to presenting features and clinical outcomes in a prospective cohort of 142 patients. (12637323)	Vesely S.K.... Raskob G.E.	2003
43	Anticardiolipin antibodies in D+ hemolytic uremic syndrome. (12478355)	e Loo M.... Monnens L.	2002
44	Circulating inflammatory cytokine levels in hemolytic uremic syndrome. (10603133)	Litalien C.... Seidman E.	1999
45	Markers of thrombin generation in kidney failure of children with epidemic hemolytic uremic syndrome]. (9674202)	Marta R.F.... Molinas F.C.	1998
46	Activation of both coagulation and fibrinolysis in childhood hemolytic uremic syndrome. (9767551)	van Geet C.... Declerck P.J.	1998
47	A 12-year-old boy with fatal hemolytic-uremic-syndrome, excessive neutrophilia and elevated endogenous granulocyte-colony-stimulating-factor serum concentrations. (9710348)	Vierzig A.... Michalk D.	1998
48	Profiles of circulating inflammatory- and anti-inflammatory cytokines in patients with hemolytic uremic syndrome due to E. coli O157 infection. (9702419)	Murata A.... Okada S.	1998
49	Enterohemorrhagic Escherichia coli and hemolytic-uremic syndrome]. (9381722)	Allerberger F.... Karch H.	1997
50	Atypical Hemolytic-Uremic Syndrome (20301541)	Pagon R.A.... Stephens K.	1993

Genes related to Hemolytic-Uremic Syndrome

Sources:
¹⁸GeneCards, ¹antibodies-online, ⁴⁵Novus Biologicals
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Genes related to Hemolytic-Uremic Syndrome:

- Elite gene

id	Symbol	Description	Score	Implication
1	CFH	complement factor H	22.20	GeneCards inferred via : Publications, Disorders, Summaries (show sections)
2	CD46	CD46 molecule, complement regulatory protein	18.86	GeneCards inferred via : Publications, Disorders (show sections)
3	CFHR1	complement factor H-related 1	15.50	GeneCards inferred via : Publications, Disorders, Summaries (show sections)
4	CFHR3	complement factor H-related 3	12.16	GeneCards inferred via : Publications, Disorders, Summaries (show sections)
5	CFI	complement factor I	8.63	GeneCards inferred via : Publications, Disorders (show sections)
6	CFB	complement factor B	5.29	GeneCards inferred via : Publications, Disorders (show sections)

Products for genes related to Hemolytic-Uremic Syndrome disease:

id	Company	Proteins	Lysates	Antibodies	Kits and Assays
1	Antibodies-online	5	-	6	6
2	Novus Biologicals	5	5	5	-

Variations for Hemolytic-Uremic Syndrome

Expression for genes affiliated with Hemolytic-Uremic Syndrome

Sources:
²BioGPS, ¹⁶Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hemolytic-Uremic Syndrome

Search GEO for disease gene expression data for Hemolytic-Uremic Syndrome.

Pathways for genes affiliated with Hemolytic-Uremic Syndrome

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⁴⁹PathCards, ³⁰KEGG, ³⁷NCBI BioSystems Database, ⁵²QIAGEN, ⁵⁹Thomson Reuters, ⁵⁴Reactome, ⁵⁵SinoBiological
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Pathways related to Hemolytic-Uremic Syndrome according to GeneCards/GeneDecks:

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	Staphylococcus aureus infection³⁰	8.7	CFI, CFB, CFH
2	Complement and coagulation cascades³⁰ Show member pathways Complement Activation, Classical Pathway³⁷ Complement and Coagulation Cascades³⁷	8.3	CD46, CFI, CFB, CFH
3	Complement Pathway⁵² Show member pathways Immune response Alternative complement pathway⁵⁹ Classical Complement Pathway⁵² Terminal pathway of complement⁵⁴ Complement Activation Pathways⁵⁵ Regulation of Complement cascade⁵⁴ Immune response Lectin Induced complement pathway⁵⁹ Activation of C3 and C5⁵⁴ Immune response Classic complement pathway⁵⁹ Lectin Induced Complement Pathway⁵² Alternative Complement Pathway⁵²	7.6	CD46, CFHR3, CFI, CFB, CFH
4	Creation of C4 and C2 activators⁵⁴ Show member pathways FCERI mediated NF-kB activation⁵⁴ Classical antibody-mediated complement activation⁵⁴ Complement cascade⁵⁴ Initial triggering of complement⁵⁴ Role of phospholipids in phagocytosis⁵⁴ FCGR activation⁵⁴ Ficolins bind to repetitive carbohydrate structures on the target cell surface⁵⁴ Alternative complement activation⁵⁴ Lectin pathway of complement activation⁵⁴	7.6	CFH, CFB, CFI, CFHR3, CD46

Compounds for genes affiliated with Hemolytic-Uremic Syndrome

Sources:
⁴⁴Novoseek, ²⁹IUPHAR, ²⁵HMDB, ¹²DrugBank
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Compounds related to Hemolytic-Uremic Syndrome according to GeneCards/GeneDecks:

id	Compound	Score	Top Affiliating Genes
1	sialic acid⁴⁴	9.3	CD46, CFH
2	heparin⁴⁴ ²⁹ ²⁵ ¹²	11.7	CFHR1, CFI, CFH
3	glucose⁴⁴	8.7	CFI, CFB, CFH
4	serine⁴⁴	8.2	CFH, CFB, CFI, CD46

GO Terms for genes affiliated with Hemolytic-Uremic Syndrome

Sources:
¹⁷Gene Ontology
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Cellular components related to Hemolytic-Uremic Syndrome according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:005615	8.1	CFHR1, CFHR3, CFI, CFH
2	blood microparticle	GO:072562	8.1	CFHR1, CFHR3, CFB, CFH

Biological processes related to Hemolytic-Uremic Syndrome according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	complement activation, alternative pathway	GO:006957	9.2	CFB, CFH
2	complement activation, classical pathway	GO:006958	9.2	CD46, CFI
3	complement activation	GO:006956	9.0	CFHR1, CFB, CFH
4	regulation of complement activation	GO:030449	8.3	CD46, CFI, CFB, CFH
5	innate immune response	GO:045087	8.2	CFH, CFB, CFI, CD46

Molecular functions related to Hemolytic-Uremic Syndrome according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	complement binding	GO:001848	9.2	CD46, CFB
2	serine-type endopeptidase activity	GO:004252	9.1	CFI, CFB

Products for genes affiliated with Hemolytic-Uremic Syndrome

Antibodies
Proteins
Lysates

Antibodies
Proteins
Kits and Assays

Sources for Hemolytic-Uremic Syndrome

¹antibodies-online

²BioGPS

³BitterDB

⁴CDC

⁵Cell Signaling Technology

⁶ClinicalTrials

⁷Clinvar

⁸dbSNP

⁹Disease Ontology

¹⁰diseasecard

¹¹DISEASES

¹²DrugBank

¹³EMD Millipore

¹⁴ExPASy

¹⁵FMA

¹⁶Gene Expression Omnibus DataSets

¹⁷Gene Ontology

¹⁸GeneCards

¹⁹GeneDecks

²⁰GeneReviews

²¹GeneTests

²²Genetics Home Reference

²³GTR

²⁴HGMD

²⁵HMDB

²⁶ICD10

²⁷ICD10 via Orphanet

²⁸ICD9CM

²⁹IUPHAR

³⁰KEGG

³¹LifeMap Discovery®

³²MalaCards

³³MedlinePlus

³⁴MeSH

³⁵MESH via Orphanet

³⁶MGI

³⁷NCBI BioSystems Database

³⁸NCBI Bookshelf

³⁹NCIt

⁴⁰NDF-RT

⁴¹NIH Clinical Center

⁴²NIH Rare Diseases

⁴³NINDS

⁴⁴Novoseek

⁴⁵Novus Biologicals

⁴⁶OMIM

⁴⁷OMIM via Orphanet

⁴⁸Orphanet

⁴⁹PathCards

⁵⁰PharmGKB

⁵¹PubMed

⁵²QIAGEN

⁵³R&D Systems

⁵⁴Reactome

⁵⁵SinoBiological

⁵⁶SNOMED-CT

⁵⁷SNOMED-CT via Orphanet

⁵⁸The Human Phenotype Ontology

⁵⁹Thomson Reuters

⁶⁰Tocris Bioscience

⁶¹UMLS

⁶²UMLS via Orphanet

⁶³UniProtKB/Swiss-Prot

⁶⁴Wikipedia

HUS MCID: HML001 MIFTS: 47	Hemolytic-Uremic Syndrome (HUS) malady Rare diseases, Blood diseases, Nephrological diseases categories
6 genes, 12 tissues, 210 related diseases, clinical trials Download this MalaCard Expand all tables

Hemolytic-Uremic Syndrome (HUS) malady