Hemolytic-Uremic Syndrome disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

HUS MCID: HML001 MIFTS: 54	Hemolytic-Uremic Syndrome (HUS) malady Nephrological diseases, Blood diseases categories
89 genes, 12 tissues, 234 related diseases, clinical trials.

Summaries for Hemolytic-Uremic Syndrome

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⁶³Wikipedia, ³²MalaCards
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Wikipedia:⁶³ Hemolytic-uremic syndrome (or haemolytic-uraemic syndrome), abbreviated HUS, is a disease characterized... more...

MalaCards: Hemolytic-Uremic Syndrome, also known as hemolytic uremic syndrome, is related to atypical hemolytic-uremic syndrome and purpura. An important gene associated with Hemolytic-Uremic Syndrome is CFH (complement factor H), and among its related pathways are Activation of C3 and C5 and Classical Complement Pathway. The compounds cardiolipin and desmopressin have been mentioned in the context of this disorder. Affiliated tissues include kidney, endothelial and liver, and related mouse phenotypes are renal/urinary system and homeostasis/metabolism.

Aliases & Classifications for Hemolytic-Uremic Syndrome

Sources:
⁸Disease Ontology, ¹⁰DISEASES, ⁴⁴Novoseek, ⁶⁰UMLS, ⁴²NIH Rare Diseases, ³⁴MeSH, ³⁹NCIt, ⁵⁶SNOMED-CT, ²⁷ICD9CM
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases, Blood diseases

Aliases & Descriptions:

hemolytic-uremic syndrome ⁸ ¹⁰ ⁴⁴ ⁶⁰

hemolytic uremic syndrome ⁸ ⁴²

acute renal failure, thrombocytopenia, and microangiopathic hemolytic anemia associated with distorted erythrocytes ⁴²

hus ⁴²

External Ids:

Disease Ontology⁸ DOID:12554

MeSH³⁴ D006463

SNOMED-CT⁵⁶ 111407006, 123308008

NCIt³⁹ C75545

ICD9CM²⁷ 283.11

UMLS⁶⁰ C0019061

Related Diseases for Hemolytic-Uremic Syndrome

Sources:
¹⁷GeneCards, ¹⁸GeneDecks
See all sources

Diseases in the Hemolytic-Uremic Syndrome family:

D-Plus Hemolytic Uremic Syndrome

Diseases related to Hemolytic-Uremic Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50) (show all 234)

id	Related Disease	Score	Top Affiliating Genes
1	atypical hemolytic-uremic syndrome	32.0	CFHR1, CFHR3
2	purpura	31.5	ADAMTS13
3	complement deficiency	30.8	C3
4	glomerulonephritis	30.8	CD46, CFI, CFH, C3
5	leukemia	30.6	MSH2, CD46, MLH1
6	membranoproliferative glomerulonephritis	30.5	C3, CFH, CD46
7	disseminated intravascular coagulation	30.5	ADAMTS13, THBD
8	hemolytic anemia	30.5	ADAMTS13, CFH, VWF
9	hellp syndrome	30.4	VWF, ADAMTS13
10	peritonitis	30.4	CFI
11	arthritis	30.2	C3, SULT1A3
12	hepatitis	30.2	CFB
13	lupus erythematosus	30.2	THBD, C3
14	hepatitis b	30.2	SULT1A3, CFB
15	age related macular degeneration	30.2	C3, CFHR1, CFH, CFB, CFHR3
16	antiphospholipid syndrome	30.2	VWF, CFH, THBD, SULT1A3, ADAMTS13
17	connective tissue disease	30.2	VWF, THBD, C3
18	nephrotic syndrome	30.2	CFI
19	vascular disease	30.2	CD46, VWF, THBD, SULT1A3
20	systemic lupus erythematosus	30.2	C4BPA, C4B, CD46, VWF, CFI, CFH
21	meningitis	30.2	CFI, CD46
22	diabetes mellitus	30.2	VWF, THBD, C3
23	adenocarcinoma	30.2	MSH2, THBD, CD46, MLH1
24	systemic scleroderma	30.2	CD46, VWF, THBD
25	rheumatoid arthritis	30.1	CFI, CFB, C3
26	myocardial infarction	29.7	VWF, CFH, SULT1A3, ADAMTS13
27	acute myocardial infarction	29.7	VWF, THBD, SULT1A3, ADAMTS13
28	transitional cell carcinoma	29.7	MSH2, THBD, MLH1
29	thrombotic thrombocytopenic purpura	11.0
30	syndromic diarrhea	10.8
31	diarrhea	10.8
32	pneumonia	10.8
33	adult syndrome	10.7
34	pancreatitis	10.5
35	anuria	10.5
36	hypertension	10.5
37	influenza	10.5
38	hemolytic uremic syndrome, atypical 2	10.5
39	hemolytic uremic syndrome, atypical, childhood	10.5
40	nephrosclerosis	10.4
41	shigellosis	10.4
42	acute leukemia	10.4
43	malignant hypertension	10.4
44	hemolytic uremic syndrome, atypical 3	10.4
45	hemolytic uremic syndrome, atypical 4	10.4
46	hemolytic uremic syndrome, atypical 5	10.4
47	hemolytic uremic syndrome, atypical 6	10.4
48	acute pancreatitis	10.4
49	acute diarrhea	10.4
50	cerebritis	10.4

Graphical network of the top 20 diseases related to Hemolytic-Uremic Syndrome:

Clinical Features for Hemolytic-Uremic Syndrome

Drugs & Therapeutics for Hemolytic-Uremic Syndrome

Sources:
⁵CenterWatch, ⁴¹NIH Clinical Center, ⁶ClinicalTrials, ⁶⁰UMLS, ⁴⁰NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Hemolytic-Uremic Syndrome

Drug clinical trials:

Search ClinicalTrials for Hemolytic-Uremic Syndrome

Search NIH Clinical Center for Hemolytic-Uremic Syndrome

Search CenterWatch for Hemolytic-Uremic Syndrome

Genetic Tests for Hemolytic-Uremic Syndrome

Anatomical Context for Hemolytic-Uremic Syndrome

Sources:
³²MalaCards
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MalaCards organs/tissues related to Hemolytic-Uremic Syndrome:

³²

Kidney, Endothelial, Liver, Lung, Prostate, Monocytes, Testes, Skin, Pancreas, Heart, Bone, Bone marrow

Animal Models for Hemolytic-Uremic Syndrome or affiliated genes

Sources:
³⁶MGI
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MGI Mouse Phenotypes related to Hemolytic-Uremic Syndrome:

³⁶

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	renal/urinary system phenotype	MP:0005367	10.4	CFI, CFB, CFH, THBD, C3, C4B
2	homeostasis/metabolism phenotype	MP:0005376	9.9	ADAMTS13, FHL1, C4B, MLH1, VWF, CFI

Publications for Hemolytic-Uremic Syndrome

Sources:
⁵⁰PubMed
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Articles related to Hemolytic-Uremic Syndrome:

(show top 50) (show all 688)

id	Title	Authors	Year
1	Hemolytic uremic syndrome related to cryptosporidium infection in an immunocompetent child. (24330289)	Printza N.... Papachristou F.	2013
2	Multifaceted hemolytic uremic syndrome in pediatrics. (23343552)	Nester C.M.	2013
3	Eculizumab in atypical hemolytic-uremic syndrome. (24088108)	Kistler A.D.	2013
4	Eculizumab for atypical hemolytic uremic syndrome in pregnancy. (23884270)	Ardissino G.... Cugno M.	2013
5	Risk factors for development of hemolytic uremic syndrome in a cohort of adult patients with STEC 0104:H4 infection. (23533606)	Zoufaly A.... Lohse A.W.	2013
6	Successful long-term treatment of TMA with eculizumab in a transplanted patient with atypical hemolytic uremic syndrome due to MCP mutation. (24247905)	Reuter S.... Suwelack B.	2013
7	Eculizumab in atypical hemolytic-uremic syndrome. (24088106)	Ring T.	2013
8	Complete sequences of plasmids from the hemolytic-uremic syndrome-associated Escherichia coli strain HUSEC41. (22207742)	KA1nne C.... Chakraborty T.	2012
9	Recent advances in the management of atypical hemolytic uremic syndrome. (23073053)	Cataland S.R.	2012
10	Membrano-proliferative glomerulonephritis, atypical hemolytic uremic syndrome, and a new complement factor H mutation: report of a case. (22669321)	Gnappi E.... Manenti L.	2012
11	Hemolytic uremic syndrome and Clostridium difficile colitis. (23882375)	Keshtkar-Jahromi M.... Mohebtash M.	2012
12	Genome sequence of the hemolytic-uremic syndrome-causing strain Escherichia coli NCCP15647. (22740672)	Jeong H.... Kim J.F.	2012
13	Clinical grand rounds: atypical hemolytic uremic syndrome. (22517061)	Hodgkins K.S.... Langman C.B.	2012
14	JAMA patient page. Hemolytic uremic syndrome. (22416108)	Punnoose A.R.... Golub R.M.	2012
15	Idiopathic Atypical Hemolytic Uremic Syndrome (aHUS) with Trilineage Myelodysplasia. (23450222)	Sethy S.... Mahapatra S.	2012
16	Diagnostic and therapeutic challenges in the thrombotic thrombocytopenic purpura and hemolytic uremic syndromes. (23233641)	George J.N.... Al-Nouri Z.L.	2012
17	Complement evaluation in atypical hemolytic uremic syndrome: current concepts. (22982929)	Sethi S.K.... Jhaveri K.D.	2012
18	Prevention of large-vessel stenoses in atypical hemolytic uremic syndrome associated with complement dysregulation. (20652819)	Davin J.C.... Loirat C.	2011
19	Streptococcus pneumoniae-associated hemolytic uremic syndrome among children in North America. (21772230)	Banerjee R.... Shah S.S.	2011
20	Optimizing treatment strategies in paediatric atypical hemolytic uremic syndrome. (21647645)	Waters A.	2011
21	Idiopathic combined, autoantibody-mediated ADAMTS-13/factor H deficiency in thrombotic thrombocytopenic purpura-hemolytic uremic syndrome in a 17-year-old woman: a case report. (22206706)	Patschan D.... Koziolek M.	2011
22	Mouse model for hemolytic uremic syndrome induced by outer membrane vesicles of Escherichia coli O157:H7. (22029600)	Kim S.H.... Chang K.T.	2011
23	Triggering of atypical hemolytic uremic syndrome by influenza A (H1N1). (20540647)	Bento D.... Meneses-Oliveira C.	2010
24	Platelet count and prothrombin time help distinguish thrombotic thrombocytopenic purpura-hemolytic uremic syndrome from disseminated intravascular coagulation in adults. (20154285)	Park Y.A.... Marques M.B.	2010
25	Excessive activation of the complement system in atypical hemolytic uremic syndrome: is it ready for prime time? (20118898)	Tsai H.M.	2010
26	A large family with a gain-of-function mutation of complement C3 predisposing to atypical hemolytic uremic syndrome, microhematuria, hypertension and chronic renal failure. (19590060)	Lhotta K.... Fremeaux-Bacchi V.	2009
27	Belatacept as immunosuppression in patient with recurrence of hemolytic uremic syndrome after renal transplantation. (19543075)	Midtvedt K.... Holdaas H.	2009
28	Interventions for hemolytic uremic syndrome and thrombotic thrombocytopenic purpura: a systematic review of randomized controlled trials. (18950913)	Michael M.... Hodson E.M.	2009
29	Diarrhea associated hemolytic uremic syndrome: a 3-year PICU experience from Nepal. (20072865)	Baranwal A.K.... Singh R.	2009
30	Molecular analysis of shiga toxin-producing Escherichia coli strains isolated from hemolytic-uremic syndrome patients and dairy samples in France. (18245246)	Pradel N.... Livrelli V.	2008
31	Short-term and long-term outcome of hemolytic uremic syndrome in Iranian children. (18949724)	Otukesh H.... Tabarroki A.	2008
32	Lessons learned from the Oklahoma thrombotic thrombocytopenic purpura-hemolytic uremic syndrome registry. (18618590)	George J.N.... Vesely S.K.	2008
33	Pneumococcal hemolytic uremic syndrome: about 2 cases]. (18524552)	Chautemps N.... Picaud J.C.	2008
34	Albuminuria and estimated GFR 5 years after Escherichia coli O157 hemolytic uremic syndrome: an update. (18295059)	Garg A.X.... Clark W.F.	2008
35	Hemolytic uremic syndrome and thrombotic thrombocytopenic purpura. Current perspectives on EHEC, complement mutations and ADAMTS13]. (18561752)	Karpman D.	2008
36	Atypical hemolytic uremic syndrome and the CFH gene]. (19134264)	Jiang C.R.... Yu Z.H.	2008
37	Pancreatitis preceding acute episodes of thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: report of five patients with a systematic review of published reports. (17606444)	Swisher K.K.... George J.N.	2007
38	Deletion of complement factor H-related genes CFHR1 and CFHR3 is associated with atypical hemolytic uremic syndrome. (17367211)	Zipfel P.F.... Skerka C.	2007
39	Complement factor H and the hemolytic uremic syndrome. (17548524)	Atkinson J.P.... Goodship T.H.	2007
40	Role of fibroblast growth factor-binding protein in the pathogenesis of HIV-associated hemolytic uremic syndrome. (16352855)	Ray P.E.... Wellstein A.	2006
41	Activation of innate and specific immune responses in hemolytic uremic syndrome (HUS)-patients]. (17354472)	Palermo M.S.... Isturiz M.A.	2006
42	Atypical hemolytic uremic syndrome. (11867846)	D'Souza I.E.... Subba Rao S.D.	2002
43	Basic fibroblast growth factor among children with diarrhea-associated hemolytic uremic syndrome. (11856774)	Ray P.... Trachtman H.	2002
44	Plasmapheresis in a very young infant with atypical hemolytic uremic syndrome. (11198613)	Magen D.... Zelikovic I.	2001
45	The molecular basis of familial hemolytic uremic syndrome: mutation analysis of factor H gene reveals a hot spot in short consensus repeat 20. (11158219)	Caprioli J.... Noris M.	2001
46	Hemolytic uremic syndrome associated with immunoglobulin A nephropathy: a case report and review of cases of hemolytic uremic syndrome with glomerular disease. (10411356)	Morita S.... Kasuga M.	1999
47	Anticardiolipin antibodies in classic pediatric hemolytic-uremic syndrome: a possible pathogenic role. (9546687)	Ardiles L.G.... Mezzano S.	1998
48	Primary tubular impairment by verocytotoxin in hemolytic uremic syndrome]. (9086788)	Uchida H.... Takeda T.	1997
49	Immune response to Escherichia coli O157:H7 in hemolytic uremic syndrome following salmonellosis. (9260252)	Flores F.X.... Somers M.J.	1997
50	Clostridium septicum sepsis and cerebritis: a rare complication of the hemolytic-uremic syndrome. (3380585)	Riccio J.A.... Oberkircher O.R.	1988

Genes related to Hemolytic-Uremic Syndrome

Sources:
¹⁷GeneCards, ⁴⁵Novus Biologicals, ³¹LifeSpan BioSciences, Inc.
See all sources

Genes related to Hemolytic-Uremic Syndrome:

(show top 50) (show all 89)

id	Symbol	Description	Score	Implication
1	CFH	complement factor H	20.15	GeneCards inferred : Publications, Disorders, Summaries (show sections)
2	CD46	CD46 molecule, complement regulatory protein	19.92	GeneCards inferred : Publications, Disorders, Summaries (show sections)
3	CFHR1	complement factor H-related 1	19.70	GeneCards inferred : Publications, Disorders, Summaries (show sections)
4	CFHR3	complement factor H-related 3	19.47	GeneCards inferred : Publications, Disorders, Summaries (show sections)
5	CFI	complement factor I	19.23	GeneCards inferred : Publications, Disorders (show sections)
6	CFB	complement factor B	19.01	GeneCards inferred : Publications, Disorders (show sections)
7	THBD	thrombomodulin	18.78	GeneCards inferred : Publications, Disorders (show sections)
8	C3	complement component 3	18.56	GeneCards inferred : Publications, Disorders (show sections)
9	ADAMTS13	ADAM metallopeptidase with thrombospondin type 1 motif, 13	18.33	GeneCards inferred : Publications, Disorders (show sections)
10	CFHR5	complement factor H-related 5	18.10	GeneCards inferred : Publications, Disorders (show sections)
11	CFHR2	complement factor H-related 2	17.88	GeneCards inferred : Publications, Disorders (show sections)
12	C4B	complement component 4B (Chido blood group)	17.65	GeneCards inferred : Publications, Disorders (show sections)
13	C4BPA	complement component 4 binding protein, alpha	17.43	GeneCards inferred : Publications, Disorders (show sections)
14	VWF	von Willebrand factor	17.20	GeneCards inferred : Publications, Disorders (show sections)
15	FHL1	four and a half LIM domains 1	16.98	GeneCards inferred : Disorders (show sections)
16	MLH1	mutL homolog 1	16.75	GeneCards inferred : Publications, Disorders (show sections)
17	MSH2	mutS homolog 2	16.53	GeneCards inferred : Publications, Disorders (show sections)
18	SULT1A3	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3	16.30	GeneCards inferred : Publications, Disorders (show sections)
19	CFHR4	complement factor H-related 4	16.08	GeneCards inferred : Publications, Disorders (show sections)
20	C4BPB	complement component 4 binding protein, beta	15.85	GeneCards inferred : Publications, Disorders (show sections)
21	FGFBP1	fibroblast growth factor binding protein 1	15.62	GeneCards inferred : Publications, Disorders (show sections)
22	CX3CL1	chemokine (C-X3-C motif) ligand 1	15.40	GeneCards inferred : Publications, Disorders (show sections)
23	HP	haptoglobin	15.17	GeneCards inferred : Publications, Disorders (show sections)
24	FIBP	fibroblast growth factor (acidic) intracellular binding protein	14.95	GeneCards inferred : Publications, Disorders (show sections)
25	USE1	unconventional SNARE in the ER 1 homolog (S. cerevisiae)	14.72	GeneCards inferred : Disorders (show sections)
26	PRF1	perforin 1 (pore forming protein)	14.50	GeneCards inferred : Publications, Disorders (show sections)
27	CXCL5	chemokine (C-X-C motif) ligand 5	14.27	GeneCards inferred : Publications, Disorders (show sections)
28	SERPINB1	serpin peptidase inhibitor, clade B (ovalbumin), member 1	14.05	GeneCards inferred : Publications, Disorders (show sections)
29	NEU1	sialidase 1 (lysosomal sialidase)	13.82	GeneCards inferred : Publications, Disorders (show sections)
30	STX1B	syntaxin 1B	13.60	GeneCards inferred : Disorders (show sections)
31	APOH	apolipoprotein H (beta-2-glycoprotein I)	13.38	GeneCards inferred : Publications, Disorders (show sections)
32	PLA2G7	phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)	13.15	GeneCards inferred : Publications, Disorders (show sections)
33	C1S	complement component 1, s subcomponent	12.93	GeneCards inferred : Publications, Disorders (show sections)
34	CCL4	chemokine (C-C motif) ligand 4	12.70	GeneCards inferred : Publications, Disorders (show sections)
35	PLAU	plasminogen activator, urokinase	12.48	GeneCards inferred : Publications, Disorders (show sections)
36	STX1A	syntaxin 1A (brain)	12.25	GeneCards inferred : Disorders (show sections)
37	CD79A	CD79a molecule, immunoglobulin-associated alpha	12.03	GeneCards inferred : Publications, Disorders (show sections)
38	A4GALT	alpha 1,4-galactosyltransferase	11.80	GeneCards inferred : Disorders (show sections)
39	B3GALNT1	beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)	11.58	GeneCards inferred : Disorders (show sections)
40	GUSB	glucuronidase, beta	11.35	GeneCards inferred : Publications, Disorders (show sections)
41	CST3	cystatin C	11.13	GeneCards inferred : Publications, Disorders (show sections)
42	RECK	reversion-inducing-cysteine-rich protein with kazal motifs	10.90	GeneCards inferred : Publications, Disorders (show sections)
43	CABIN1	calcineurin binding protein 1	10.68	GeneCards inferred : Publications, Disorders (show sections)
44	F3	coagulation factor III (thromboplastin, tissue factor)	10.45	GeneCards inferred : Publications, Disorders (show sections)
45	TLR4	toll-like receptor 4	10.23	GeneCards inferred : Publications, Disorders (show sections)
46	IL1R1	interleukin 1 receptor, type I	10.00	GeneCards inferred : Publications, Disorders (show sections)
47	CLU	clusterin	9.78	GeneCards inferred : Publications, Disorders (show sections)
48	WT1	Wilms tumor 1	9.56	GeneCards inferred : Publications, Disorders (show sections)
49	F2	coagulation factor II (thrombin)	9.33	GeneCards inferred : Publications, Disorders (show sections)
50	STX2	syntaxin 2	9.11	GeneCards inferred : Disorders (show sections)

Products for genes related to Hemolytic-Uremic Syndrome disease:

id	Company	Proteins	Lysates	Antibodies
1	Novus Biologicals	49	49	48
2	LSBio	-	-	50

Genetic Variations for Hemolytic-Uremic Syndrome

Expression for genes affiliated with Hemolytic-Uremic Syndrome

Sources:
¹BioGPS, ¹⁵Gene Expression Omnibus DataSets
See all sources

Expression patterns in normal tissues for genes affiliated with Hemolytic-Uremic Syndrome

Search GEO for disease gene expression data for Hemolytic-Uremic Syndrome.

Pathways for genes affiliated with Hemolytic-Uremic Syndrome

Sources:
⁵³Reactome, ⁵¹QIAGEN, ³⁷NCBI BioSystems Database, ⁵⁵SinoBiological, ²⁹KEGG, ¹²EMD Millipore
See all sources

Pathways related to Hemolytic-Uremic Syndrome according to GeneCards/GeneDecks:

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	Activation of C3 and C5⁵³ Hide members Alternative complement activation⁵³	10.4	C3, CFB
2	Classical Complement Pathway⁵¹ Hide members Complement Activation, Classical Pathway³⁷ Complement Pathway⁵¹ Lectin Induced Complement Pathway⁵¹ Complement Activation Pathways⁵⁵	10.4	C3, CD46, C4B, CFH
3	Immune System⁵³ Hide members Adaptive Immune System⁵³ Innate Immune System⁵³	10.4	CFH, C3, CFHR3, CFI, CFB
4	Staphylococcus aureus infection²⁹	10.4	C4B, CFI, C3, CFB, CFH
5	Classical antibody-mediated complement activation⁵³ Hide members Complement cascade⁵³ Initial triggering of complement⁵³	10.4	CFB, CFI, CFHR3, CD46, CFH, C3
6	Pertussis²⁹	10.4	C4BPB, C3, C4B, C4BPA
7	Immune response Lectin induced complement pathway Hide members Immune response Alternative complement pathway¹² Regulation of Complement cascade⁵³ Immune response Lectin Induced complement pathway¹² Immune response Classic complement pathway¹²	10.3	C4BPA, C4BPB, C4B, C3, CFH, CFB
8	Complement and coagulation cascades²⁹ Hide members Complement and Coagulation Cascades³⁷	10.3	C4BPB, C4BPA, C3, THBD, CFH, CFB

Compounds for genes affiliated with Hemolytic-Uremic Syndrome

Sources:
⁴⁴Novoseek, ¹¹DrugBank, ⁵⁹Tocris Bioscience, ²⁸IUPHAR, ⁴⁹PharmGKB, ²⁴HMDB
See all sources

Compounds related to Hemolytic-Uremic Syndrome according to GeneCards/GeneDecks:

(show all 32)

id	Compound	Score	Top Affiliating Genes
1	cardiolipin⁴⁴ ¹¹	11.8	CFH
2	desmopressin⁴⁴ ⁵⁹ ²⁸ ¹¹	13.8	ADAMTS13, VWF, THBD
3	nacl⁴⁴	10.8	CFI, ADAMTS13, SULT1A3, THBD, CFH
4	serine⁴⁴	10.8	ADAMTS13, C3, MSH2, CD46, C4BPB
5	cyclophosphamide⁴⁴ ⁴⁹ ¹¹	12.7	CD46, ADAMTS13, THBD, VWF
6	carbohydrates⁴⁴	10.7	C4B, VWF, CFI, THBD
7	agarose⁴⁴	10.7	MLH1, VWF, C3, THBD, CFB, C4B
8	beraprost sodium⁴⁴	10.7	THBD, VWF
9	creatinine⁴⁴	10.7	ADAMTS13, C3, VWF, THBD, CFI, SULT1A3
10	cholesterol⁴⁴ ²⁸ ¹¹ ²⁴	13.7	C4BPA, VWF, CFH, CFI, THBD, SULT1A3
11	fibrinogen⁴⁴	10.7	ADAMTS13, THBD, C3, SULT1A3, CFH, CFI
12	cyclosporin a⁴⁴ ²⁸ ⁵⁹	12.7	CFH, ADAMTS13, THBD, VWF, CD46
13	kininogen⁴⁴	10.7	CFI, THBD, VWF
14	paraffin⁴⁴	10.7	CD46, THBD, MLH1, MSH2, VWF
15	n-methyl-n-nitrosourea⁴⁴	10.7	MSH2, MLH1
16	alanine⁴⁴	10.7	MSH2, CFH, THBD, MLH1, C4BPB, VWF
17	dexamethasone⁴⁴ ⁴⁹ ²⁸ ¹¹	13.7	THBD, CD46, SULT1A3, C3, CFH, VWF
18	aspirin⁴⁴ ⁴⁹ ²⁸ ²⁴	13.7	MLH1, SULT1A3, THBD, VWF
19	Intravenous Immunoglobulin¹¹	10.7	C3, C4B
20	steroid⁴⁴	10.7	C3, SULT1A3, C4B, MLH1, THBD, ADAMTS13
21	heparin⁴⁴ ²⁸ ¹¹ ²⁴	13.7	ADAMTS13, C4BPA, C4BPB, CFI, CFHR2, CFHR4
22	methionine⁴⁴	10.6	CFI, THBD, MLH1, VWF
23	polysaccharide⁴⁴	10.6	THBD, CD46, CFH, C3
24	estrogen⁴⁴	10.6	C3, MLH1, VWF, CFI, THBD, SULT1A3
25	11-dehydrothromboxane b2⁴⁴	10.6	VWF, THBD
26	progesterone⁴⁴ ⁵⁹ ²⁸ ¹¹ ²⁴	14.6	SULT1A3, C3, MLH1, CD46, THBD
27	phospholipid⁴⁴	10.5	C4BPB, THBD, C3, VWF
28	biotin⁴⁴ ¹¹ ²⁴	12.5	MLH1, VWF, MSH2
29	homocysteine⁴⁴ ²⁴	11.4	THBD, VWF, SULT1A3
30	mononucleotide⁴⁴	10.3	MSH2, MLH1
31	calcium⁴⁴ ⁴⁹ ¹¹ ²⁴	13.3	CFI, ADAMTS13, C4BPA, VWF, CD46, MLH1
32	6-ketoprostaglandin f1alpha⁴⁴	10.1	VWF, THBD

GO Terms for genes affiliated with Hemolytic-Uremic Syndrome

Sources:
¹⁶Gene Ontology
See all sources

Cellular components related to Hemolytic-Uremic Syndrome according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:005615	10.4	CFHR3, CFI, CFH, CFHR1, C3, ADAMTS13
2	extracellular region	GO:005576	9.9	C3, C4BPA, C4BPB, C4B, VWF, CFHR4

Biological processes related to Hemolytic-Uremic Syndrome according to GeneCards/GeneDecks:

(show all 7)

id	Name	GO ID	Score	Top Affiliating Genes
1	regulation of complement activation	GO:030449	10.5	C3, CFH, CFB, CFI, CD46, C4B
2	complement activation	GO:006956	10.5	C3, CFH, CFHR1, CFB, C4B
3	complement activation, classical pathway	GO:006958	10.5	C4BPB, C4B, CD46, CFI, C3, C4BPA
4	isotype switching	GO:045190	10.4	MSH2, MLH1
5	complement activation, alternative pathway	GO:006957	10.4	C3, CFHR5, CFH, CFB
6	innate immune response	GO:045087	10.2	CFI, CD46, CFB, CFH, C4BPB, C3
7	somatic hypermutation of immunoglobulin genes	GO:016446	10.1	MSH2, MLH1