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MCID: HML001

Hemolytic-uremic Syndrome malady
76 genes, 6 tissues, 962 related diseases, 22 phenotypes, 165 articles, clinical trials.

Summaries for Hemolytic-uremic Syndrome

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17Genetics Home Reference, 44Wikipedia, 22MalaCards
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Genetics Home Reference: Atypical hemolytic-uremic syndrome is a disease that primarily affects kidney function. This condition, which can occur at any age, causes abnormal blood clots (thrombi) to form in small blood vessels in the kidneys. These clots can cause serious medical problems if they restrict or block blood flow. Atypical hemolytic-uremic syndrome is characterized by three major features related to abnormal clotting: hemolytic anemia, thrombocytopenia, and kidney failure.17

MalaCards: Hemolytic-uremic Syndrome, also known as hemolytic uremic syndrome, is related to atypical hemolytic-uremic syndrome and malignant hypertension. An important gene associated with Hemolytic-uremic Syndrome is CFH (complement factor H), and among its related pathways are Complement cascade and Bacterial infections in CF airways. The compounds polyethylene glycol and cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, kidney and liver, and related mouse phenotypes are respiratory system and renal/urinary system.

Wikipedia: Hemolytic-uremic syndrome (or haemolytic-uraemic syndrome), abbreviated HUS, is a disease characterized...44 more...

Aliases & Descriptions for Hemolytic-uremic Syndrome

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6Disease Ontology, 7diseasecard, 30NIH Rare Diseases, 8DISEASES, 32Novoseek , 43UMLS, 40SNOMED-CT, 24MeSH, 27NCIt, 19ICD9CM
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Aliases & Descriptions:

hemolytic-uremic syndrome 6 7 8 32 43
hemolytic uremic syndrome 6 30
acute renal failure, thrombocytopenia, and microangiopathic hemolytic anemia associated with distorted erythrocytes ('burr cells') 30
hus 30

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ICD9CM19 283.11

Related Diseases for Hemolytic-uremic Syndrome

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13GeneCards, 14GeneDecks
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Diseases related to hemolytic-uremic syndrome by text searches and GeneDecks gene sharing:

(show top 50)    (show all 959)
idRelated DiseaseScoreTop Affiliating Genes
1atypical hemolytic-uremic syndrome39.6CFB, CFH, CFHR1, CFHR3, CFI, CD46
2malignant hypertension30.6VWF, APOH, ADAMTS13
3acute poststreptococcal glomerulonephritis30.6CD79A, ALB, HP, C5
4hemolytic anemia30.6VWF, CFH, APOH, F3, HP, NEU1
5systemic scleroderma29.5VWF, CD40LG, CD46, APOH, CCL4, TIMP1
6thrombophilia29.2VWF, SELP, SERPINC1, SERPINE1, APOH, F8
7hepatitis29.0SELP, GUSB, F2, ALB, TGFB1
8hellp syndrome28.9VWF, SERPINC1, SERPINE1, CD46, IL6, APOH
9rheumatoid arthritis28.9IL1R1, IL1RN, CRP
10immunodeficiency28.8CD79A, CD40LG, INS, IL10, IL2, IL6
11glomerulopathy28.2VWF, SELP, CFH, CFHR5, CD79A, CD40LG
12beta thalassemia27.6SERPINC1, INS, F2, ALB, HP, HLA-C
13lung carcinoma27.5RECK, CFH, CD46, MMP9, GUSB, IL1R1
14hemoglobinopathy27.5VWF, CFB, HP, THBD, EPO
15arthritis27.4IL1B, IL6, IL8, TNF, TIMP1
16breast cancer27.0RECK, MSH2, MMP9, MLH1, IL10, IL1B
17hepatitis b27.0IL10, F2, ALB, TGFB1
18catastrophic antiphospholipid syndrome26.8SERPINE1, CFH, CD40LG, APOH, F8, F3
19colorectal cancer26.6MSH2, MLH1, TNF, TLR4, TGFB1
20renal cell carcinoma26.6SELP, CLU, CD46, MMP9, FGF2, IL1R1
21squamous cell carcinoma26.4RECK, CLU, MSH2, CD46, MMP9, MLH1
22west nile virus26.0CFH, CD40LG, IL1B, IL6, F8, ALB
23disseminated intravascular coagulation25.4VWF, SERPINC1, SERPINE1, CD40LG, IL10, IL1B
24amyotrophic lateral sclerosis25.2SERPINE1, CD79A, MMP9, FGF2, IL8, CCL4
25lateral sclerosis25.2SERPINE1, CD79A, MMP9, FGF2, IL8, CCL4
26purpura25.2RECK, VWF, SELP, SERPINC1, SERPINE1, CFB
27tuberculosis25.1IL10, IL1B, IL1RN, TNF, TLR4
28waldenstrom macroglobulinemia24.6CD40LG, IL10, IL1B, IL6, ALB, TNF
29tonsillitis24.5CLU, CFI, CD79A, CD40LG, IL10, IL2
30prostate cancer, progression of24.5RECK, SERPINE1, MMP9, FGF2, IL6, TGFB1
31thalassemia24.3VWF, SERPINC1, CFB, INS, IL1B, IL6
32macroglobulinemia24.2CD79A, CD40LG, IL10, IL1B, IL6, F2
33diarrhea24.1VWF, USE1, CFB, CFH, CFHR5, CFI
34vaccinia24.0SERPINB1, CFI, INS, IL10, IL2, CCL4
35focal segmental glomerulosclerosis23.8CD79A, IL10, IL6, ALB, CABIN1, TNF
36choriocarcinoma23.7INS, IL1B, APOH, F2, ALB, CABIN1
37gastroenteritis23.6CD79A, GUSB, IL10, IL1B, IL1RN, IL2
38endometrial carcinoma23.6SERPINE1, CLU, MSH2, MMP9, MLH1, FGF2
39encephalomyelitis23.5CFH, CD40LG, MMP9, IL10, IL1B, IL1R1
40twinning22.8VWF, SERPINC1, SERPINE1, CFB, CFH, CD79A
41antiphospholipid syndrome22.8VWF, SELP, SERPINC1, SERPINE1, CFH, CD79A
42severe combined immunodeficiency22.1SELP, CD40LG, MLH1, INS, IL10, IL1B
43combined immunodeficiency22.1SELP, CD40LG, MLH1, INS, IL10, IL1B
44inflammatory bowel disease22.0SELP, MLH1, GUSB, IL10, IL1B, IL1R1
45colon adenocarcinoma21.8CLU, CD46, MMP9, MLH1, GUSB, INS
46chondrosarcoma21.5MMP9, FGF2, IL10, IL1B, IL6, IL8
47pancreatic carcinoma21.2CLU, MMP9, FGF2, IL10, IL1B, IL2
48leiomyoma21.1VWF, SERPINE1, MMP9, FGF2, IL1B, IL1RN
49colon carcinoma21.1SELP, SERPINE1, MSH2, MMP9, MLH1, GUSB
50sjogren's syndrome21.1CD79A, CD40LG, MMP9, IL10, IL1B, IL1R1

Graphical network of the top 20 diseases related to hemolytic-uremic syndrome:



Graphical network of diseases related to hemolytic-uremic syndrome

Clinical Features for Hemolytic-uremic Syndrome

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Drugs & Therapeutics for Hemolytic-uremic Syndrome

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4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
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Genetic Tests for Hemolytic-uremic Syndrome

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Anatomical Context for Hemolytic-uremic Syndrome

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22MalaCards
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MalaCards organs/tissues related to hemolytic-uremic syndrome:

22
Bone marrow, Kidney, Liver, Pancreas, B cells, Endothelial

Phenotypes for genes affiliated with Hemolytic-uremic Syndrome

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25MGI
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MGI Mouse Phenotypes related to hemolytic-uremic syndrome:

25 (show all 22)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1respiratory system phenotypeMP:000538810.3C5, SERPINB1, SELP
2renal/urinary system phenotypeMP:00053679.6C3, C4B, WT1, INS, CFI, CFH
3hematopoietic system phenotypeMP:00053979.5SERPINB1, MSH2, FGF2, HLA-C, C4B, CX3CL1
4endocrine/exocrine gland phenotypeMP:00053799.2STX2, STX1B, WT1, IL2, GUSB, CD40LG
5integument phenotypeMP:00107719.0NEU1, CSF3, TLR4, F2, F3, IL1R1
6digestive/alimentary phenotypeMP:00053818.5C3, STX2, TGFB1, C4B, PLAU, PLAT
7liver/biliary system phenotypeMP:00053708.1EPO, C3, STX2, TLR4, IL6, IL2
8skeleton phenotypeMP:00053907.8PLAT, PLAU, NEU1, C5, C3, IL6
9adipose tissue phenotypeMP:00053757.8TGFB1, TLR4, PLAU, TNF, IL6, IL1R1
10nervous system phenotypeMP:00036317.7TLR4, THBD, TGFB1, STX1B, ST8SIA2, PRF1
11normal phenotypeMP:00028737.4WT1, ELANE, THBD, STX1A, PRF1, C5
12growth/size phenotypeMP:00053787.1PLAU, WT1, TLR4, THBD, ST8SIA2, STX1A
13reproductive system phenotypeMP:00053897.1TNF, WT1, TLR4, TIMP1, TGFB1, STX2
14immune system phenotypeMP:00053877.0TNF, PLAT, WT1, ELANE, TLR4, STX2
15muscle phenotypeMP:00053697.0PLAU, WT1, TGFB1, CST3, NEU1, C3
16behavior/neurological phenotypeMP:00053866.9A4GALT, TLR4, STX1B, ST8SIA2, STX1A, PRF1
17vision/eye phenotypeMP:00053916.3TNF, PLAT, PLAU, TLR4, TGFB1, NEU1
18tumorigenesisMP:00020066.2TNF, PLAU, ELANE, TLR4, TIMP1, TGFB1
19mortality/agingMP:00107686.2ST8SIA2, STX1A, PRF1, NEU1, C3, ADAMTS13
20homeostasis/metabolism phenotypeMP:00053764.7VWF, F3, F2, ALB, HP, CRP
21cellular phenotypeMP:00053844.4WT1, PLAU, PLAT, TNF, HLA-C, HP
22cardiovascular system phenotypeMP:00053853.7HP, TNF, CRP, PLAT, PLAU, WT1

Publications for genes affiliated with Hemolytic-uremic Syndrome

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35PubMed
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Articles related to hemolytic-uremic syndrome:

(show top 50)    (show all 165)
idTitleAuthorsYearAffiliating Genes
1Factor H-related protein 1 neutralizes anti-factor H autoantibodies in autoimmune hemolytic uremic syndrome. (21677636)Strobel S.... JA^zsi M.2011CFH, CFHR1
2Atypical hemolytic uremic syndrome associated with mu tations in complement regulator genes. (20865641)Le Quintrec M.... FrAcmeaux-Bacchi V.2010CFH, CD46
3A favorable 3-year outcome of kidney transplantation in atypical hemolytic uremic syndrome associated with a factor H mutation: case report. (20534299)Albertazzi V.... Cappelli G.2010CFH
4Maintenance of kidney function following treatment wi th eculizumab and discontinuation of plasma exchange after a third kidney trans plant for atypical hemolytic uremic syndrome associated with a CFH mutation. (19854549)Davin J.C.... Goodship T.2010CFH
5Mutations in components of complement influence the o utcome of Factor I-associated atypical hemolytic uremic syndrome. (20016463)Bienaime F.... Fremeaux-Bacchi V.2010CFI, CD46, CFHR1
6Levels of urinary transforming growth factor beta-1 i n children with D+ hemolytic uremic syndrome. (20157739)Caletti M.G.... Roy A.H.2010TGFB1
7The thrombotic thrombocytopenic purpura and hemolytic uremic syndromes: overview of pathogenesis (Experience of The Oklahoma TTP-HUS Registry, 1989-2007). (19180141)George J.N.2009ADAMTS13
8The binding of factor H to a complex of physiological polyanions and C3b on cells is impaired in atypical hemolytic uremic syndrome. (19454698)Ferreira V.P.... Kavanagh D.2009CFH, C3
9Recurrent atypical hemolytic uremic syndrome associated with factor I mutation in a living related renal transplant recipient. (18805611)Chan M.R.... Samaniego M.D.2009CFH, CFI, CD46
10Efficacy of plasma therapy in atypical hemolytic uremic syndrome with complement factor H mutations. (18425537)Lapeyraque A.L.... Robitaille P.2008CFH
11Atypical hemolytic uremic syndrome and the CFH gene (19134264)Jiang C.R.... Yu Z.H.2008CFH
12Membrane cofactor protein mutations in atypical hemolytic uremic syndrome (aHUS), fatal Stx-HUS, C3 glomerulonephritis, and the HELLP syndrome. (17914026)Fang C.J.... Atkinson J.P.2008CD46
13Mutations in complement C3 predispose to development of atypical hemolytic uremic syndrome. (18796626)FrAcmeaux-Bacchi V.... Atkinson J.P.2008C3
14The complement factor H R1210C mutation is associated with atypical hemolytic uremic syndrome. (18235085)Martinez-Barricarte R.... de Cordoba S.R.2008CFH
15A novel non-synonymous polymorphism (p.Arg240His) in C4b-binding protein is associated with atypical hemolytic uremic syndrome and leads to impaired alternative pathway cofactor activity. (18424762)Blom A.M.... Goodship T.H.2008C4BPA
16Chronic course of a hemolytic uremic syndrome caused by a deficiency of factor H-related proteins (CFHR1 and CFHR3). (18449173)Koziolek M.J.... Strutz F.2008CFHR1, CFHR3
17Inherited deficiency of membrane cofactor protein expression and varying manifestations of recurrent atypical hemolytic uremic syndrome in a sibling pair. (18514989)Couzi L.... Fremeaux-Bacchi V.2008CD46
18Soluble tumor necrosis factor receptor 1 and tissue inhibitor of metalloproteinase-1 in hemolytic uremic syndrome with encephalopathy. (18410971)Shiraishi M.... Furukawa S.2008MMP9, IL6, TIMP1
19Involvement of the fractalkine pathway in the pathogenesis of childhood hemolytic uremic syndrome. (17132725)Ramos M.V.... Palermo M.S.2007CX3CL1
20A mutation in factor I that is associated with atypical hemolytic uremic syndrome does not affect the function of factor I in complement regulation. (17084897)Nilsson S.C.... Blom A.M.2007CFI, CD46, C4B
21Hemolytic uremic syndrome: a factor H mutation (E1172Stop) causes defective complement control at the surface of endothelial cells. (17229916)Heinen S.... Zipfel P.F.2007CFH
22Update on evaluating complement in hemolytic uremic syndrome. (18089972)Kavanagh D.... Goodship T.H.2007CFH, CD46
23Differential impact of complement mutations on clinical characteristics in atypical hemolytic uremic syndrome. (17599974)Sellier-Leclerc A.L.... Loirat C.2007CFH, CFI, CD46
24Deletion of complement factor H-related genes CFHR1 and CFHR3 is associated with atypical hemolytic uremic syndrome. (17367211)Zipfel P.F.... Skerka C.2007MSH2, MLH1, CFHR1
25Spontaneous hemolytic uremic syndrome triggered by complement factor H lacking surface recognition domains. (17517971)Pickering M.C.... Botto M.2007CFH
26Complement factor H and the hemolytic uremic syndrome. (17548524)Atkinson J.P.... Goodship T.H.2007CFH
27Unusual clinical severity of complement membrane cofactor protein-associated hemolytic-uremic syndrome and uniparental isodisomy. (17261436)Fremeaux-Bacchi V.... Fridman W.H.2007CFH, CFI, CD46
28Genetic and functional analyses of membrane cofactor protein (CD46) mutations in atypical hemolytic uremic syndrome. (16762990)Fremeaux-Bacchi V.... Atkinson J.P.2006CFI, CD46
29An adult with acute poststreptococcal glomerulonephritis complicated by hemolytic uremic syndrome and nephrotic syndrome. (16183409)Izumi T.... Miura S.2005HP
30Hemolytic uremic syndrome: a fatal outcome after kidney and liver transplantation performed to correct factor h gene mutation. (15816899)Remuzzi G.... Noris M.2005CFH
31Hemolytic uremic syndrome-associated Shiga toxins promote endothelial-cell secretion and impair ADAMTS13 cleavage of unusually large von Willebrand factor multimers. (16131569)Nolasco L.H.... Moake J.L.2005ADAMTS13
32Complement factor H deficiency in acute allograft glomerulopathy and post-transplant hemolytic uremic syndrome. (14974950)Fortin M.C.... Hebert M.J.2004CFH
33Decrease of thrombomodulin contributes to the procoagulant state of endothelium in hemolytic uremic syndrome. (12920633)Fernandez G.C.... Monnens L.L.2003THBD
34Severe deficiency of the specific von Willebrand factor-cleaving protease (ADAMTS 13) activity in a subgroup of children with atypical hemolytic uremic syndrome. (12640381)Veyradier A.... Loriat C.2003ADAMTS13
35Plasma exchange therapy for the treatment of Escherichia coli O-157 associated hemolytic uremic syndrome. (12373296)Nakatani T.... Takemoto Y.2002IL1R1, IL1RN
36Hemolytic uremic syndrome in twin pregnancy at 32 weeks gestation with HELLP syndrome. Case report (11431643)Pitton M.A.... Forcellini F.2001HP
37The molecular basis of familial hemolytic uremic syndrome: mutation analysis of factor H gene reveals a hot spot in short consensus repeat 20. (11158219)Caprioli J.... Noris M.2001CFH
38Function of von Willebrand factor in children with diarrhea-associated hemolytic-uremic syndrome (D+ HUS). (11446662)Sutor A.H.... Zimmerhackl L.B.2001VWF
39Thrombotic thrombocytopenic purpura and the hemolytic-uremic syndrome. (10676770)Baker K.R.... Moake J.L.2000VWF
40Hemolytic uremic syndrome associated with Denys-Drash syndrome. (11045393)Sherbotie J.R.... Kaplan B.S.2000WT1
41Hemolytic uremic syndrome associated with immunoglobulin A nephropathy: a case report and review of cases of hemolytic uremic syndrome with glomerular disease. (10411356)Morita S.... Kasuga M.1999CD79A
42A case of late onset cyclosporine-induced hemolytic uremic syndrome resulting in renal graft loss. (10751058)Katafuchi R.... Fujimi S.1999CD79A
43A 12-year-old boy with fatal hemolytic-uremic-syndrome, excessive neutrophilia and elevated endogenous granulocyte-colony-stimulating-factor serum concentrations. (9710348)Vierzig A.... Michalk D.1998CSF3
44Plasma von Willebrand Factor Antigen (vWF:AG) and thrombomodulin (TM) levels in Adult Thrombotic Thrombocytopenic Purpura/Hemolytic Uremic Syndromes (TTP/HUS) and bone marrow transplant-associated thrombotic microangiopathy (BMT-TM). (8948657)Zeigler Z.R.... George J.N.1996VWF, THBD
45Impaired fibrinolysis in the hemolytic-uremic syndrom e of childhood. (8110878)Menzel D.... Ten Cate J.W.1994PLAU
46Hypoproteinemia in the hemolytic-uremic syndrome of childhood. (8439484)Serebruany V.L.... McLean R.H.1993ALB
47Drug induced hemolytic uremic syndrome (7679450)Ito K.... Komatsu Y.1993CFH
48Postpartum hemolytic uremic syndrome associated with antiphospholipid antibodies. A case report and review of the literature. (1492877)Kniaz D.... Bregman H.1992APOH
49Hemolytic-uremic syndrome with anticardiolipin antibo dies revealing paraneoplastic systemic scleroderma. (1758545)Meyrier A.... Rainfray M.1991APOH
50The role of von Willebrand factor (vWF) in thrombotic thrombocytopenic purpura (TTP) and the hemolytic-uremic syndrome (HUS). (2191307)Moake J.L.1990VWF

Expression for genes affiliated with Hemolytic-uremic Syndrome

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Hemolytic-uremic Syndrome

Pathways for genes affiliated with Hemolytic-uremic Syndrome

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38Reactome, 41Thomson Reuters, 10EMD Millipore, 20KEGG, 36QIAGEN, 37R&D Systems
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Pathways related to hemolytic-uremic syndrome according to GeneDecks:

(show top 50)    (show all 85)
idPathwayScoreTop Affiliating Genes
1Complement cascade3810.6C4BPB, C4BPA, C1S, CD46, CFI, CFH
2Bacterial infections in CF airways4110.5IL1R1
3Immune response_Alternative complement pathway4110.5CFB, CFH, CFI, CD46, C5, C3
4Immune response Alternative complement pathway1010.5C3, CLU, CFB, CFH, CFI, CD46
5Immune response_Lectin induced complement pathway4110.5CFI, CD46, C4B, C4BPA, C4BPB, C5
6Immune response Lectin Induced complement pathway1010.4C3, C5, CLU, CFI, CD46, C4B
7Immune response_Classical complement pathway4110.4CFI, CD46, C1S, C4B, C4BPA, C4BPB
8Graft-versus-host disease2010.2PRF1, HLA-C, IL2
9Staphylococcus aureus infection2010.1C3, C5, C4B, C1S, IL10, CFI
10Immune response Classic complement pathway109.9C3, C5, CLU, CFI, CD46, CRP
11RAR-Gamma-RXR-Alpha Degradation369.8CSF3, CXCL5, CX3CL1, CCL4, IL2
12Systemic lupus erythematosus209.6C3, C5, C4B, C1S, TNF, IL10
13Blood Coagulation Signaling Pathways379.6THBD, PLAU, PLAT, F2, F3, F8
14Allograft rejection209.4PRF1, TNF, HLA-C, IL2, IL10, CD40LG
15PGC1Alpha Pathway369.2CCL4, IL8, IL2, IL1R1, IL1B
16Complement and coagulation cascades209.1C5, C3, THBD, C4BPB, VWF, SERPINC1
17Type I diabetes mellitus209.0PRF1, TNF, HLA-C, IL2, IL1B, INS
18Akt Signaling368.8CXCL5, TNF, CCL4, IL6, IL2, IL10
19Cell adhesion_ECM remodeling418.7MMP9, IL8, PLAT, PLAU, TIMP1, SERPINE1
20Cell adhesion ECM remodeling108.6TIMP1, PLAU, PLAT, IL8, MMP9, SERPINE1
21IL-10 Pathway368.6IL10, IL1B, IL6, TNF, TLR4
22Endothelin-1 Signaling Pathway368.5CSF3, CXCL5, CX3CL1, IL6, IL2, IL1B
23Amoebiasis208.5TGFB1, TLR4, IL8, IL6, IL1R1, IL1B
24Immune response IL-1 signaling pathway108.3TNF, F3, IL8, IL6, IL1R1, IL1B
25Immune response_IL-1 signaling pathway418.3TNF, F3, IL8, IL6, IL1R1, IL1B
26Molecular Mechanisms of Cancer368.2TGFB1, TIMP1, IL6, IL2, IL1R1, FGF2
27Cytokine Network368.1TNF, IL8, IL6, IL2, IL1B, IL10
28Rheumatoid arthritis208.1CXCL5, TGFB1, TLR4, TNF, IL8, IL6
29NF-KappaB (p50-p65) Pathway368.0TGFB1, TIMP1, TLR4, TNF, IL6, IL2
30Pertussis208.0C3, IL10, IL1B, IL6, IL8, TNF
31NF-KappaB Family Pathway367.9TGFB1, TIMP1, TLR4, TNF, IL6, IL2
32Rho Family GTPases367.9CSF3, CXCL5, CX3CL1, TGFB1, TIMP1, CCL4
33ERK Signaling367.8CSF3, CXCL5, CX3CL1, TGFB1, TIMP1, IL6
34Tec Kinases Signaling367.8TGFB1, TIMP1, TLR4, CCL4, IL8, IL6
35Chagas disease (American trypanosomiasis)207.5TNF, TLR4, TGFB1, C3, IL8, IL6
36all-trans-Retinoic Acid Signaling in Brain367.5TNF, CX3CL1, CXCL5, CSF3, CCL4, IL8
37PEDF Induced Signaling367.5TNF, CX3CL1, CXCL5, CSF3, CCL4, IL8
38TGF-Beta Pathway367.5TGFB1, TIMP1, CCL4, IL8, IL6, IL2
39Malaria207.4CSF3, TGFB1, TLR4, TNF, IL8, IL6
40MIF Mediated Glucocorticoid Regulation367.4CSF3, CXCL5, CX3CL1, TLR4, TNF, CCL4
41MIF Regulation of Innate Immune Cells367.3CSF3, CXCL5, CX3CL1, TLR4, TNF, CCL4
42STAT3 Pathway367.3CSF3, CXCL5, CX3CL1, TNF, CCL4, IL8
43IL-6 Pathway367.3CSF3, CXCL5, CX3CL1, TIMP1, TNF, CCL4
44SOCS Pathway367.3CCL4, IL8, IL6, IL2, IL1B, IL10
45MAPK Family Pathway367.1TGFB1, TIMP1, TNF, CCL4, IL8, IL6
46JAK-STAT Pathway367.1EPO, TGFB1, TIMP1, F2, CCL4, IL8
47PAK Pathway366.9CSF3, CXCL5, CX3CL1, TGFB1, TIMP1, TNF
48Cytokine-cytokine receptor interaction206.7TNF, TGFB1, CX3CL1, CXCL5, CSF3, EPO
49p38 Signaling366.7TNF, TIMP1, TGFB1, CX3CL1, CXCL5, CSF3
50Antioxidant Action of Vitamin-C366.6PLA2G7, TIMP1, TGFB1, CX3CL1, CXCL5, CSF3

Compounds for genes affiliated with Hemolytic-uremic Syndrome

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32Novoseek , 34PharmGKB, 9DrugBank, 18HMDB, 42Tocris Bioscience
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Compounds related to hemolytic-uremic syndrome according to GeneDecks:

(show top 50)    (show all 367)
idCompoundScoreTop Affiliating Genes
1polyethylene glycol32 10.2THBD, HP, F8, SERPINC1, CST3, NEU1
2cyclophosphamide32 34 9 9 13.1F8, APOH
3citrate32 10.0CD79A, SELP, GUSB, FGF2, F8, HP
4ivig32 10.0PLA2G7, CRP, F8, CCL4, VWF
5hyaluronic acid32 18 10.9NEU1, THBD, ELANE, WT1, F2, FGF2
6tranexamic acid32 9 9 11.6VWF, EPO, C1S, PLAU, PLAT, F8
7dermatan sulfate32 9.4VWF, SELP, THBD, PLAU, PLAT, F2
8agarose32 9.2CFB, CLU, VWF, MLH1, IL1RN, APOH
9aprotinin32 9 9 11.1F2, MMP9, SERPINC1, SELP, VWF, PLAT
10desmopressin32 42 9 9 12.0VWF, SELP, SERPINC1, SERPINE1, EPO, ADAMTS13
11rituximab32 34 9 9 12.0C1S, CRP, F8, IL2, IL1R1, IL10
12warfarin32 34 9 18 9 12.9CD79A, SERPINC1, SELP, VWF, FGF2, APOH
13n acetylcysteine32 8.8CST3, TIMP1, TLR4, PLAU, F2, IL1R1
14aspartate32 8.7CST3, THBD, PLAU, SULT1A3, HP, F2
15calcitriol32 42 9 18 9 12.7CLU, EPO, THBD, TIMP1, WT1, PLAU
16endotoxin32 8.6F3, F8, CCL4, APOH, IL1R1, RECK
17kininogen32 8.4CFI, CLU, SERPINE1, SERPINC1, SELP, VWF
18mycophenolate mofetil32 9 9 10.4EPO, CSF3, THBD, CABIN1, ALB, IL2
19homocysteine32 18 9.2IL1R1, SERPINE1, SERPINC1, SELP, VWF, APOH
20polysaccharide32 8.2CFH, CLU, SERPINC1, SELP, RECK, TLR4
21atorvastatin32 34 9 18 9 12.0THBD, TIMP1, TLR4, PLAT, PLA2G7, CRP
22folate32 8.0APOH, MLH1, MMP9, CD40LG, CD79A, CLU
23epinephrine32 9 18 9 11.0CD79A, SELP, MMP9, CXCL5, ELANE, PLAU
24histamine32 18 8.9NEU1, THBD, TIMP1, TLR4, PLAU, PLAT
25cysteine32 7.8C3, NEU1, CFH, CLU, SELP, RECK
26infliximab32 9 9 9.7IL1B, IL10, FGF2, IL1R1, TIMP1, TLR4
27rantes32 7.5MMP9, CD46, CD40LG, SELP, IL1R1, IL2
28paraffin32 7.4MLH1, MMP9, CD46, CD40LG, CD79A, MSH2
29etanercept32 9 9 9.3TIMP1, C1S, CRP, TNF, APOH, IL8
30prostacyclin32 7.3THBD, TIMP1, ELANE, C1S, PLAU, VWF
31il 1032 7.2CCL4, IL8, IL6, IL2, IL1RN, IL1R1
32gabexate mesilate32 7.1IL6, IL10, MMP9, SERPINC1, IL8, TNF
33pentoxifylline32 9 9 9.0THBD, ELANE, TNF, HP, F3, IL8
34gm-csf32 7.0EPO, CSF3, TGFB1, ELANE, TNF, IL8
35creatinine32 7.0EPO, ADAMTS13, IL1R1, GUSB, MMP9, CD40LG
368-isoprostane32 6.9THBD, CRP, TNF, HP, APOH, IL8
37aspirin32 34 18 8.8TGFB1, THBD, TIMP1, TLR4, ELANE, C1S
38prednisolone32 9 9 8.7IL2, IL1RN, IL1R1, IL10, FGF2, CD79A
39simvastatin32 34 42 9 18 9 11.4F2, F3, CCL4, IL8, IL6, IL1RN
40nitric oxide32 9 18 9 9.1CCL4, VWF, APOH, IL8, IL6, IL1RN
41cholesterol32 9 18 9 9.0PLAT, CFH, CLU, SERPINE1, SELP, VWF
42actinomycin d32 5.7TGFB1, THBD, TIMP1, TLR4, PLAU, PLAT
43methotrexate32 34 42 9 9 9.7EPO, CST3, CSF3, TGFB1, TIMP1, CRP
44vegf32 5.6CSF3, CXCL5, TGFB1, THBD, TIMP1, WT1
45fibrinogen32 5.5THBD, IL6, IL1RN, IL1R1, INS, CD40LG
46alanine32 5.1F8, CCL4, IL6, IL1RN, IL1R1, FGF2
47retinoic acid32 42 18 7.1NEU1, CSF3, TGFB1, THBD, TIMP1, TLR4
48serine32 3.9TLR4, ELANE, C4BPB, C4BPA, C4B, C1S
49lactate32 3.7THBD, TIMP1, TLR4, ELANE, C4BPA, PLAU
50dexamethasone32 42 34 9 9 7.4IL1RN, SELP, VWF, SERPINC1, SERPINE1, CLU

GO Terms for genes affiliated with Hemolytic-uremic Syndrome

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Sources:
12Gene Ontology
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Cellular components related to hemolytic-uremic syndrome according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.4VWF, SELP, CD79A, CD40LG, TNF, TLR4
2extracellular matrixGO:0310129.4PLAT, F3, APOH, CLU, SERPINE1, VWF
3platelet alpha granule lumenGO:0310939.1TGFB1, TIMP1, ALB, F8, CLU, SERPINE1
4cell surfaceGO:0099868.8THBD, TGFB1, STX2, CX3CL1, ADAMTS13, ELANE
5plasma membraneGO:0058867.0HLA-C, TNF, PLAU, C4B, C4BPA, C4BPB
6extracellular regionGO:0055762.7EPO, VWF, FGF2, IL1B, IL1R1, IL2
7extracellular spaceGO:0056151.9SELP, FGF2, FGFBP1, IL10, IL1B, IL1RN

Biological processes related to hemolytic-uremic syndrome according to GeneDecks:

(show all 49)
idNameGO IDScoreTop Affiliating Genes
1complement activation, alternative pathwayGO:00695710.6C3, C5, CFHR5, CFH, CFB
2regulation of complement activationGO:03044910.6CFB, C3, C4BPB, C4BPA, C4B, CD46
3complement activationGO:00695610.4C3, C5, C4B, C1S, CFHR1, CFH
4chronic inflammatory response to antigenic stimulusGO:00243910.4IL1B, IL1RN
5negative regulation of fibrinolysisGO:05191810.3THBD, F2, APOH, SERPINE1
6positive regulation of blood coagulationGO:03019410.2F2, APOH, SERPINE1
7blood coagulation, intrinsic pathwayGO:00759710.2VWF, APOH, F8, F2
8negative regulation of blood coagulationGO:03019510.2THBD, APOH, SERPINE1
9fibrinolysisGO:04273010.2PLAU, PLAT, F2, SERPINE1
10positive regulation of MHC class II biosynthetic processGO:04534810.1TLR4, IL10, CD40LG
11B cell proliferationGO:04210010.1IL10, CD40LG, CD79A
12positive regulation vascular endothelial growth factor productionGO:01057510.1C3, C5, TGFB1, IL1B
13B cell differentiationGO:03018310.1IL10, CD40LG, CD79A, MSH2
14positive regulation of interleukin-8 biosynthetic processGO:04541610.1TLR4, ELANE, TNF
15positive regulation of inflammatory responseGO:05072910.0CX3CL1, TLR4, PLA2G7, IL2, SERPINE1
16innate immune responseGO:04508710.0C3, C5, TLR4, C4BPB, C4BPA, C4B
17hyaluronan catabolic processGO:03021410.0TGFB1, FGF2, GUSB
18complement activation, classical pathwayGO:0069589.9C3, C5, C4BPB, C4BPA, C4B, C1S
19lipopolysaccharide-mediated signaling pathwayGO:0316639.8TGFB1, TLR4, TNF, IL1B
20embryo implantationGO:0075669.7EPO, IL1B, MMP9, RECK
21positive regulation of protein phosphorylationGO:0019349.6C3, TGFB1, TNF, F2, IL1B
22activation of MAPK activityGO:0001879.6C5, TLR4, TNF, IL1B, FGF2
23negative regulation of proteolysisGO:0458619.6PLAT, F2, INS
24positive regulation of interferon-gamma productionGO:0327299.5TLR4, TNF, IL2, IL1B, CD40LG
25defense response to Gram-negative bacteriumGO:0508299.5SELP, SERPINE1, IL6, TLR4
26positive regulation of nitric oxide biosynthetic processGO:0454299.5TLR4, TNF, IL1B, INS
27agingGO:0075689.5EPO, TGFB1, TIMP1, F3, IL1B
28response to hyperoxiaGO:0550939.5MMP9, SERPINE1, EPO
29platelet degranulationGO:0025769.4TGFB1, TIMP1, ALB, F8, CLU, SERPINE1
30positive regulation of angiogenesisGO:0457669.4C3, C5, CX3CL1, F3, IL1B, FGF2
31proteolysisGO:0065089.3PLAU, C1S, ELANE, ADAMTS13, PLAT, F2
32response to lipopolysaccharideGO:0324969.3EPO, THBD, TLR4, ELANE, F3, MMP9
33positive regulation of smooth muscle cell proliferationGO:0486619.2IL6, TNF, ELANE, CX3CL1
34negative regulation of lipid storageGO:0108889.2IL6, TNF, CRP
35positive regulation of interleukin-6 productionGO:0327559.2IL1B, IL6, TNF, TLR4
36negative regulation of lipid catabolic processGO:0509959.0TNF, IL1B, INS
37cell-cell signalingGO:0072678.9CXCL5, CCL4, IL2, IL1B, IL10, FGFBP1
38anti-apoptosisGO:0069168.9EPO, TNF, F3, IL2, IL1B, IL10
39response to glucocorticoid stimulusGO:0513848.6PLAT, TNF, IL6, IL1RN, IL1B, IL10
40response to hypoxiaGO:0016668.6CX3CL1, TGFB1, TLR4, PLAT, CRP, TNF
41immune responseGO:0069558.5CX3CL1, CXCL5, CSF3, C3, TLR4, HLA-C
42blood coagulationGO:0075968.4PLAT, PLAU, C4BPB, TIMP1, THBD, TGFB1
43acute-phase responseGO:0069538.4CRP, F2, F8, IL6, IL1RN, INS
44positive regulation of NF-kappaB transcription factor activityGO:0510928.4TGFB1, TLR4, TNF, IL6, IL1B, INS
45platelet activationGO:0301688.1ALB, TIMP1, TGFB1, CX3CL1, ADAMTS13, F2
46negative regulation of cell proliferationGO:0082857.9TGFB1, WT1, TNF, IL8, IL6, IL1B
47negative regulation of apoptotic processGO:0430667.8EPO, CX3CL1, TIMP1, WT1, TNF, ALB
48positive regulation of cell proliferationGO:0082847.5EPO, CSF3, CXCL5, TGFB1, TIMP1, F2
49inflammatory responseGO:0069547.2CRP, C4B, TGFB1, C5, C3, TNF

Molecular functions related to hemolytic-uremic syndrome according to GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1endopeptidase inhibitor activityGO:00486610.1C3, C5, CST3, C4B, RECK
2serine-type endopeptidase activityGO:0042529.6ELANE, C1S, PLAU, PLAT, F2, CFI
3heparin bindingGO:0082019.5APOH, FGFBP1, FGF2, SERPINC1, SELP, ELANE
4chemokine activityGO:0080099.4C5, CXCL5, CX3CL1, CCL4, IL8
5eukaryotic cell surface bindingGO:0434999.4SELP, APOH, TGFB1, EPO
6protease bindingGO:0020208.8SERPINC1, CST3, ELANE, TNF, F3, IL1R1
7growth factor activityGO:0080837.7CSF3, TGFB1, F2, IL6, IL2, IL1B
8cytokine activityGO:0051257.7CSF3, TNF, CCL4, IL6, IL2, IL1B
9protein bindingGO:0055153.7TIMP1, TLR4, ELANE, C4BPA, WT1, PLAU

Sources for Hemolytic-uremic Syndrome

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2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
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