HUS
MCID: HML001
MIFTS: 54

Hemolytic-Uremic Syndrome (HUS) malady

Nephrological diseases, Blood diseases categories

Summaries for Hemolytic-Uremic Syndrome

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63Wikipedia, 32MalaCards
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Wikipedia:63 Hemolytic-uremic syndrome (or haemolytic-uraemic syndrome), abbreviated HUS, is a disease characterized... more...

MalaCards: Hemolytic-Uremic Syndrome, also known as hemolytic uremic syndrome, is related to atypical hemolytic-uremic syndrome and purpura. An important gene associated with Hemolytic-Uremic Syndrome is CFH (complement factor H), and among its related pathways are Activation of C3 and C5 and Classical Complement Pathway. The compounds cardiolipin and desmopressin have been mentioned in the context of this disorder. Affiliated tissues include kidney, endothelial and liver, and related mouse phenotypes are renal/urinary system and homeostasis/metabolism.

Aliases & Classifications for Hemolytic-Uremic Syndrome

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 42NIH Rare Diseases, 34MeSH, 39NCIt, 56SNOMED-CT, 27ICD9CM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases, Blood diseases


Aliases & Descriptions:

hemolytic-uremic syndrome 8 10 44 60
hemolytic uremic syndrome 8 42
acute renal failure, thrombocytopenia, and microangiopathic hemolytic anemia associated with distorted erythrocytes 42
hus 42


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Disease Ontology8 DOID:12554
MeSH34 D006463
NCIt39 C75545
ICD9CM27 283.11

Related Diseases for Hemolytic-Uremic Syndrome

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17GeneCards, 18GeneDecks
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Diseases in the Hemolytic-Uremic Syndrome family:

D-Plus Hemolytic Uremic Syndrome

Diseases related to Hemolytic-Uremic Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 234)
idRelated DiseaseScoreTop Affiliating Genes
1atypical hemolytic-uremic syndrome32.0CFHR1, CFHR3
2purpura31.5ADAMTS13
3complement deficiency30.8C3
4glomerulonephritis30.8CD46, CFI, CFH, C3
5leukemia30.6MSH2, CD46, MLH1
6membranoproliferative glomerulonephritis30.5C3, CFH, CD46
7disseminated intravascular coagulation30.5ADAMTS13, THBD
8hemolytic anemia30.5ADAMTS13, CFH, VWF
9hellp syndrome30.4VWF, ADAMTS13
10peritonitis30.4CFI
11arthritis30.2C3, SULT1A3
12hepatitis30.2CFB
13lupus erythematosus30.2THBD, C3
14hepatitis b30.2SULT1A3, CFB
15age related macular degeneration30.2C3, CFHR1, CFH, CFB, CFHR3
16antiphospholipid syndrome30.2VWF, CFH, THBD, SULT1A3, ADAMTS13
17connective tissue disease30.2VWF, THBD, C3
18nephrotic syndrome30.2CFI
19vascular disease30.2CD46, VWF, THBD, SULT1A3
20systemic lupus erythematosus30.2C4BPA, C4B, CD46, VWF, CFI, CFH
21meningitis30.2CFI, CD46
22diabetes mellitus30.2VWF, THBD, C3
23adenocarcinoma30.2MSH2, THBD, CD46, MLH1
24systemic scleroderma30.2CD46, VWF, THBD
25rheumatoid arthritis30.1CFI, CFB, C3
26myocardial infarction29.7VWF, CFH, SULT1A3, ADAMTS13
27acute myocardial infarction29.7VWF, THBD, SULT1A3, ADAMTS13
28transitional cell carcinoma29.7MSH2, THBD, MLH1
29thrombotic thrombocytopenic purpura11.0
30syndromic diarrhea10.8
31diarrhea10.8
32pneumonia10.8
33adult syndrome10.7
34pancreatitis10.5
35anuria10.5
36hypertension10.5
37influenza10.5
38hemolytic uremic syndrome, atypical 210.5
39hemolytic uremic syndrome, atypical, childhood10.5
40nephrosclerosis10.4
41shigellosis10.4
42acute leukemia10.4
43malignant hypertension10.4
44hemolytic uremic syndrome, atypical 310.4
45hemolytic uremic syndrome, atypical 410.4
46hemolytic uremic syndrome, atypical 510.4
47hemolytic uremic syndrome, atypical 610.4
48acute pancreatitis10.4
49acute diarrhea10.4
50cerebritis10.4

Graphical network of the top 20 diseases related to Hemolytic-Uremic Syndrome:



Diseases related to hemolytic-uremic syndrome

Clinical Features for Hemolytic-Uremic Syndrome

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Drugs & Therapeutics for Hemolytic-Uremic Syndrome

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Hemolytic-Uremic Syndrome

Drug clinical trials:

Search ClinicalTrials for Hemolytic-Uremic Syndrome

Search NIH Clinical Center for Hemolytic-Uremic Syndrome

Search CenterWatch for Hemolytic-Uremic Syndrome

Genetic Tests for Hemolytic-Uremic Syndrome

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Anatomical Context for Hemolytic-Uremic Syndrome

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32MalaCards
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MalaCards organs/tissues related to Hemolytic-Uremic Syndrome:

32
Kidney, Endothelial, Liver, Lung, Prostate, Monocytes, Testes, Skin, Pancreas, Heart, Bone, Bone marrow

Animal Models for Hemolytic-Uremic Syndrome or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Hemolytic-Uremic Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536710.4CFI, CFB, CFH, THBD, C3, C4B
2MP:00053769.9ADAMTS13, FHL1, C4B, MLH1, VWF, CFI

Publications for Hemolytic-Uremic Syndrome

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50PubMed
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Articles related to Hemolytic-Uremic Syndrome:

(show top 50)    (show all 688)
idTitleAuthorsYear
1
Hemolytic uremic syndrome related to cryptosporidium infection in an immunocompetent child. (24330289)
2013
2
Multifaceted hemolytic uremic syndrome in pediatrics. (23343552)
2013
3
Eculizumab in atypical hemolytic-uremic syndrome. (24088108)
2013
4
Eculizumab for atypical hemolytic uremic syndrome in pregnancy. (23884270)
2013
5
Risk factors for development of hemolytic uremic syndrome in a cohort of adult patients with STEC 0104:H4 infection. (23533606)
2013
6
Successful long-term treatment of TMA with eculizumab in a transplanted patient with atypical hemolytic uremic syndrome due to MCP mutation. (24247905)
2013
7
Eculizumab in atypical hemolytic-uremic syndrome. (24088106)
2013
8
Complete sequences of plasmids from the hemolytic-uremic syndrome-associated Escherichia coli strain HUSEC41. (22207742)
2012
9
Recent advances in the management of atypical hemolytic uremic syndrome. (23073053)
2012
10
Membrano-proliferative glomerulonephritis, atypical hemolytic uremic syndrome, and a new complement factor H mutation: report of a case. (22669321)
2012
11
Hemolytic uremic syndrome and Clostridium difficile colitis. (23882375)
2012
12
Genome sequence of the hemolytic-uremic syndrome-causing strain Escherichia coli NCCP15647. (22740672)
2012
13
Clinical grand rounds: atypical hemolytic uremic syndrome. (22517061)
2012
14
JAMA patient page. Hemolytic uremic syndrome. (22416108)
2012
15
Idiopathic Atypical Hemolytic Uremic Syndrome (aHUS) with Trilineage Myelodysplasia. (23450222)
2012
16
Diagnostic and therapeutic challenges in the thrombotic thrombocytopenic purpura and hemolytic uremic syndromes. (23233641)
2012
17
Complement evaluation in atypical hemolytic uremic syndrome: current concepts. (22982929)
2012
18
Prevention of large-vessel stenoses in atypical hemolytic uremic syndrome associated with complement dysregulation. (20652819)
2011
19
Streptococcus pneumoniae-associated hemolytic uremic syndrome among children in North America. (21772230)
2011
20
Optimizing treatment strategies in paediatric atypical hemolytic uremic syndrome. (21647645)
2011
21
Idiopathic combined, autoantibody-mediated ADAMTS-13/factor H deficiency in thrombotic thrombocytopenic purpura-hemolytic uremic syndrome in a 17-year-old woman: a case report. (22206706)
2011
22
Mouse model for hemolytic uremic syndrome induced by outer membrane vesicles of Escherichia coli O157:H7. (22029600)
2011
23
Triggering of atypical hemolytic uremic syndrome by influenza A (H1N1). (20540647)
2010
24
Platelet count and prothrombin time help distinguish thrombotic thrombocytopenic purpura-hemolytic uremic syndrome from disseminated intravascular coagulation in adults. (20154285)
2010
25
Excessive activation of the complement system in atypical hemolytic uremic syndrome: is it ready for prime time? (20118898)
2010
26
A large family with a gain-of-function mutation of complement C3 predisposing to atypical hemolytic uremic syndrome, microhematuria, hypertension and chronic renal failure. (19590060)
2009
27
Belatacept as immunosuppression in patient with recurrence of hemolytic uremic syndrome after renal transplantation. (19543075)
2009
28
Interventions for hemolytic uremic syndrome and thrombotic thrombocytopenic purpura: a systematic review of randomized controlled trials. (18950913)
2009
29
Diarrhea associated hemolytic uremic syndrome: a 3-year PICU experience from Nepal. (20072865)
2009
30
Molecular analysis of shiga toxin-producing Escherichia coli strains isolated from hemolytic-uremic syndrome patients and dairy samples in France. (18245246)
2008
31
Short-term and long-term outcome of hemolytic uremic syndrome in Iranian children. (18949724)
2008
32
Lessons learned from the Oklahoma thrombotic thrombocytopenic purpura-hemolytic uremic syndrome registry. (18618590)
2008
33
Pneumococcal hemolytic uremic syndrome: about 2 cases]. (18524552)
2008
34
Albuminuria and estimated GFR 5 years after Escherichia coli O157 hemolytic uremic syndrome: an update. (18295059)
2008
35
Hemolytic uremic syndrome and thrombotic thrombocytopenic purpura. Current perspectives on EHEC, complement mutations and ADAMTS13]. (18561752)
2008
36
Atypical hemolytic uremic syndrome and the CFH gene]. (19134264)
2008
37
Pancreatitis preceding acute episodes of thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: report of five patients with a systematic review of published reports. (17606444)
2007
38
Deletion of complement factor H-related genes CFHR1 and CFHR3 is associated with atypical hemolytic uremic syndrome. (17367211)
2007
39
Complement factor H and the hemolytic uremic syndrome. (17548524)
2007
40
Role of fibroblast growth factor-binding protein in the pathogenesis of HIV-associated hemolytic uremic syndrome. (16352855)
2006
41
Activation of innate and specific immune responses in hemolytic uremic syndrome (HUS)-patients]. (17354472)
2006
42
Atypical hemolytic uremic syndrome. (11867846)
2002
43
Basic fibroblast growth factor among children with diarrhea-associated hemolytic uremic syndrome. (11856774)
2002
44
Plasmapheresis in a very young infant with atypical hemolytic uremic syndrome. (11198613)
2001
45
The molecular basis of familial hemolytic uremic syndrome: mutation analysis of factor H gene reveals a hot spot in short consensus repeat 20. (11158219)
2001
46
Hemolytic uremic syndrome associated with immunoglobulin A nephropathy: a case report and review of cases of hemolytic uremic syndrome with glomerular disease. (10411356)
1999
47
Anticardiolipin antibodies in classic pediatric hemolytic-uremic syndrome: a possible pathogenic role. (9546687)
1998
48
Primary tubular impairment by verocytotoxin in hemolytic uremic syndrome]. (9086788)
1997
49
Immune response to Escherichia coli O157:H7 in hemolytic uremic syndrome following salmonellosis. (9260252)
1997
50
Clostridium septicum sepsis and cerebritis: a rare complication of the hemolytic-uremic syndrome. (3380585)
1988

Genetic Variations for Hemolytic-Uremic Syndrome

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Expression for genes affiliated with Hemolytic-Uremic Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hemolytic-Uremic Syndrome

Search GEO for disease gene expression data for Hemolytic-Uremic Syndrome.

Pathways for genes affiliated with Hemolytic-Uremic Syndrome

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53Reactome, 51QIAGEN, 37NCBI BioSystems Database, 55SinoBiological, 29KEGG, 12EMD Millipore
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Compounds for genes affiliated with Hemolytic-Uremic Syndrome

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44Novoseek, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 49PharmGKB, 24HMDB
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Compounds related to Hemolytic-Uremic Syndrome according to GeneCards/GeneDecks:

(show all 32)
idCompoundScoreTop Affiliating Genes
1cardiolipin44 1111.8CFH
2desmopressin44 59 28 1113.8ADAMTS13, VWF, THBD
3nacl4410.8CFI, ADAMTS13, SULT1A3, THBD, CFH
4serine4410.8ADAMTS13, C3, MSH2, CD46, C4BPB
5cyclophosphamide44 49 1112.7CD46, ADAMTS13, THBD, VWF
6carbohydrates4410.7C4B, VWF, CFI, THBD
7agarose4410.7MLH1, VWF, C3, THBD, CFB, C4B
8beraprost sodium4410.7THBD, VWF
9creatinine4410.7ADAMTS13, C3, VWF, THBD, CFI, SULT1A3
10cholesterol44 28 11 2413.7C4BPA, VWF, CFH, CFI, THBD, SULT1A3
11fibrinogen4410.7ADAMTS13, THBD, C3, SULT1A3, CFH, CFI
12cyclosporin a44 28 5912.7CFH, ADAMTS13, THBD, VWF, CD46
13kininogen4410.7CFI, THBD, VWF
14paraffin4410.7CD46, THBD, MLH1, MSH2, VWF
15n-methyl-n-nitrosourea4410.7MSH2, MLH1
16alanine4410.7MSH2, CFH, THBD, MLH1, C4BPB, VWF
17dexamethasone44 49 28 1113.7THBD, CD46, SULT1A3, C3, CFH, VWF
18aspirin44 49 28 2413.7MLH1, SULT1A3, THBD, VWF
19Intravenous Immunoglobulin1110.7C3, C4B
20steroid4410.7C3, SULT1A3, C4B, MLH1, THBD, ADAMTS13
21heparin44 28 11 2413.7ADAMTS13, C4BPA, C4BPB, CFI, CFHR2, CFHR4
22methionine4410.6CFI, THBD, MLH1, VWF
23polysaccharide4410.6THBD, CD46, CFH, C3
24estrogen4410.6C3, MLH1, VWF, CFI, THBD, SULT1A3
2511-dehydrothromboxane b24410.6VWF, THBD
26progesterone44 59 28 11 2414.6SULT1A3, C3, MLH1, CD46, THBD
27phospholipid4410.5C4BPB, THBD, C3, VWF
28biotin44 11 2412.5MLH1, VWF, MSH2
29homocysteine44 2411.4THBD, VWF, SULT1A3
30mononucleotide4410.3MSH2, MLH1
31calcium44 49 11 2413.3CFI, ADAMTS13, C4BPA, VWF, CD46, MLH1
326-ketoprostaglandin f1alpha4410.1VWF, THBD

GO Terms for genes affiliated with Hemolytic-Uremic Syndrome

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16Gene Ontology
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Cellular components related to Hemolytic-Uremic Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.4CFHR3, CFI, CFH, CFHR1, C3, ADAMTS13
2extracellular regionGO:0055769.9C3, C4BPA, C4BPB, C4B, VWF, CFHR4

Biological processes related to Hemolytic-Uremic Syndrome according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1regulation of complement activationGO:03044910.5C3, CFH, CFB, CFI, CD46, C4B
2complement activationGO:00695610.5C3, CFH, CFHR1, CFB, C4B
3complement activation, classical pathwayGO:00695810.5C4BPB, C4B, CD46, CFI, C3, C4BPA
4isotype switchingGO:04519010.4MSH2, MLH1
5complement activation, alternative pathwayGO:00695710.4C3, CFHR5, CFH, CFB
6innate immune responseGO:04508710.2CFI, CD46, CFB, CFH, C4BPB, C3
7somatic hypermutation of immunoglobulin genesGO:01644610.1MSH2, MLH1

Molecular functions related to Hemolytic-Uremic Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1guanine/thymine mispair bindingGO:03213710.4MSH2, MLH1
2complement bindingGO:00184810.1CFB, CD46

Products for genes affiliated with Hemolytic-Uremic Syndrome

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Sources for Hemolytic-Uremic Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet