MCID: HML033
MIFTS: 46

Hemolytic Uremic Syndrome, Atypical 1

Categories: Genetic diseases, Rare diseases, Nephrological diseases, Blood diseases, Immune diseases

Aliases & Classifications for Hemolytic Uremic Syndrome, Atypical 1

MalaCards integrated aliases for Hemolytic Uremic Syndrome, Atypical 1:

Name: Hemolytic Uremic Syndrome, Atypical 1 54
Ahus 50 24 25 56 71
Atypical Hemolytic Uremic Syndrome 50 29 69
Atypical Hemolytic-Uremic Syndrome 24 25 56
Atypical Hus 50 24 56
Hemolytic-Uremic Syndrome Without Diarrhea 56 71
Hemolytic-Uremic Syndrome 71 69
Hemolytic-Uremic Syndrome Without Diarrhea with Anti-Factor H Antibodies 56
Atypical Hemolytic-Uremic Syndrome with Anti-Factor H Antibodies 56
Hemolytic Uremic Syndrome, Atypical, Susceptibility to, 1 13
Atypical Hemolytic Uremic Syndrome with H Factor Anomaly 71
Hemolytic Uremic Syndrome, Atypical, Susceptibility to 29
Atypical Hus with Anti-Factor H Antibodies 56
Hemolytic-Uremic Syndrome with Diarrhea 56
Hereditary Hemolytic-Uremic Syndrome 24
Hemolytic Uremic Syndrome Atypical 1 71
Atypical Hemolytic-Uremic Syndrome 1 29
Hemolytic Uremic Syndrome, Atypical 54
Non-Shiga-Like Toxin-Associated Hus 25
D-Hus with Anti-Factor H Antibodies 56
Familial Hemolytic-Uremic Syndrome 24
Ahus with Anti-Factor H Antibodies 56
Hemolytic Uremic Syndrome, Typical 69
Typical Hemolytic-Uremic Syndrome 56
Shiga-Like Toxin-Associated Hus 56
Nonenteropathic Hus 25
Hus, Atypical 50
Non-Stx-Hus 25
Typical Hus 56
Sxt-Hus 56
D-Hus 56
D+hus 56
D Hus 71
Ahus1 71

Characteristics:

Orphanet epidemiological data:

56
atypical hemolytic-uremic syndrome
Inheritance: Autosomal dominant,Autosomal recessive,Not applicable; Prevalence: 1-9/1000000 (United States),1-9/1000000 (Europe); Age of onset: All ages; Age of death: any age;
typical hemolytic-uremic syndrome
Inheritance: Not applicable; Prevalence: 1-9/100000 (United States); Age of onset: All ages;

OMIM:

54
Inheritance:
autosomal dominant
autosomal recessive

Miscellaneous:
diarrhea-associated (d+hus), occurs in children younger than 3 years, associated with verotoxin-producing e. coli (90% of patients) (typical hus)
d+hus (typical hus) is usually sporadic, limited to 1 event, and has a good prognosis
diarrhea-negative subtype (d-hus), or atypical hus, is more severe and often relapses
d-hus is usually familial
phenotypic overlap with thrombotic thrombocytopenic purpura (ttp, )
may be triggered by medications, including antineoplastic agents, immunotherapeutic agents, and antiplatelet agents


HPO:

32
hemolytic uremic syndrome, atypical 1:
Inheritance autosomal recessive inheritance autosomal dominant inheritance


Classifications:



Summaries for Hemolytic Uremic Syndrome, Atypical 1

NIH Rare Diseases : 50 atypical hemolytic uremic syndrome (ahus) is a disease that causes abnormal blood clots to form in small blood vessels in the kidneys. these clots can cause serious medical problems if they restrict or block blood flow, including hemolytic anemia, thrombocytopenia, and kidney failure. it can occur at any age and is often caused by a combination of environmental and genetic factors. genetic factors involve genes that code for proteins that help control the complement system (part of your body’s immune system). environmental factors include certain medications (such as anticancer drugs), chronic diseases (e.g., systemic sclerosis and malignant hypertension), viral or bacterial infections, cancers, organ transplantation, and pregnancy. in about 60% of ahus, a gene mutation may be identified. the genes associated with genetic ahus include c3, cd46 (mcp), cfb, cfh, cfhr1, cfhr3, cfhr4, cfi, dgke, and thbd. mutations in these genes  increase the likelihood (predisposition) to developing ahus, rather than directly causing the disease. most cases are sporadic. in familiar cases, predisposition to ahus is inherited in an autosomal dominant or an autosomal recessive pattern of inheritance. atypical hemolytic uremic syndrome differs from a more common condition called typical hemolytic uremic syndrome. the two disorders have different causes and different signs and symptoms. last updated: 1/23/2017

MalaCards based summary : Hemolytic Uremic Syndrome, Atypical 1, also known as ahus, is related to hemolytic uremic syndrome, atypical 2 and hemolytic uremic syndrome, atypical 3, and has symptoms including thrombocytopenia, hematuria and proteinuria. An important gene associated with Hemolytic Uremic Syndrome, Atypical 1 is CFH (Complement Factor H), and among its related pathways/superpathways is Immune response Lectin induced complement pathway. The drugs Complement Inactivating Agents and Complement System Proteins have been mentioned in the context of this disorder. Affiliated tissues include kidney.

UniProtKB/Swiss-Prot : 71 Hemolytic uremic syndrome atypical 1: An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease.

Genetics Home Reference : 25 Atypical hemolytic-uremic syndrome is a disease that primarily affects kidney function. This condition, which can occur at any age, causes abnormal blood clots (thrombi) to form in small blood vessels in the kidneys. These clots can cause serious medical problems if they restrict or block blood flow. Atypical hemolytic-uremic syndrome is characterized by three major features related to abnormal clotting: hemolytic anemia, thrombocytopenia, and kidney failure.

OMIM : 54
Typical hemolytic uremic syndrome is characterized by acute renal failure, thrombocytopenia, and microangiopathic hemolytic anemia associated with distorted erythrocytes ('burr cells'). The vast majority of cases (90%) are sporadic, occur in children under 3 years of age, and are associated with epidemics of diarrhea caused by verotoxin-producing E. coli. The death rate is very low, about 30% of cases have renal sequelae, and there is usually no relapse of the disease. This form of HUS usually presents with a diarrhea prodrome (thus referred to as D+HUS) and has a good prognosis in most cases. In contrast, a subgroup of patients with HUS have an atypical presentation (aHUS or D-HUS) without a prodrome of enterocolitis and diarrhea and have a much poorer prognosis, with a tendency to relapse and frequent development of end-stage renal failure or death. These cases tend to be familial. Both autosomal recessive and autosomal dominant inheritance have been reported (Goodship et al., 1997; Taylor, 2001; Veyradier et al., 2003; Noris et al., 2003). Noris and Remuzzi (2009) provided a detailed review of atypical HUS. (235400)

Related Diseases for Hemolytic Uremic Syndrome, Atypical 1

Diseases in the Hemolytic Uremic Syndrome, Atypical 1 family:

Hemolytic Uremic Syndrome, Atypical 2 Hemolytic Uremic Syndrome, Atypical 3
Hemolytic Uremic Syndrome, Atypical 4 Hemolytic Uremic Syndrome, Atypical 5
Hemolytic Uremic Syndrome, Atypical 6 C3-Related Atypical Hemolytic-Uremic Syndrome
Cd46-Related Atypical Hemolytic-Uremic Syndrome Cfb-Related Atypical Hemolytic-Uremic Syndrome
Cfh-Related Atypical Hemolytic-Uremic Syndrome Cfi-Related Atypical Hemolytic-Uremic Syndrome
Dgke-Related Atypical Hemolytic-Uremic Syndrome Thbd-Related Atypical Hemolytic-Uremic Syndrome

Diseases related to Hemolytic Uremic Syndrome, Atypical 1 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 31)
id Related Disease Score Top Affiliating Genes
1 hemolytic uremic syndrome, atypical 2 12.4
2 hemolytic uremic syndrome, atypical 3 12.4
3 hemolytic uremic syndrome, atypical 4 12.4
4 hemolytic uremic syndrome, atypical 5 12.4
5 hemolytic uremic syndrome, atypical 6 12.4
6 hemolytic uremic syndrome, atypical, childhood 12.4
7 thbd-related atypical hemolytic-uremic syndrome 12.1
8 genetic atypical hemolytic-uremic syndrome 12.1
9 cfi-related atypical hemolytic-uremic syndrome 12.1
10 dgke-related atypical hemolytic-uremic syndrome 12.1
11 atypical hemolytic-uremic syndrome with h factor anomaly 12.1
12 c3-related atypical hemolytic-uremic syndrome 12.1
13 cd46-related atypical hemolytic-uremic syndrome 12.1
14 cfb-related atypical hemolytic-uremic syndrome 12.1
15 cfh-related atypical hemolytic-uremic syndrome 12.1
16 cfhr1 and cfhr4-related atypical hemolytic-uremic syndrome 12.1
17 cfhr3 and cfhr1-related atypical hemolytic-uremic syndrome 12.1
18 nephrotic syndrome, type 7 11.8
19 hemolytic-uremic syndrome 10.4
20 complement factor h deficiency 10.3 CFH CFHR1
21 symphalangism, proximal, 1a 10.2 CFH DGKE
22 uterine adnexa cancer 10.1 CFH CFHR1
23 der kaloustian mcintosh silver syndrome 10.1 CFH CFHR5
24 aleutian mink disease 10.0 CFH CFHR5
25 placental choriocarcinoma 9.9 CFH CFHR1 CFHR3
26 thumb stiff brachydactyly mental retardation 9.8 CFH THBD
27 dolk-congenital disorder of glycosylation 9.7 CFHR1 CFHR3 CFHR5
28 acute proliferative glomerulonephritis 9.6 CFH THBD
29 granuloma annulare 9.6 CFH CFHR5
30 macular degeneration, age-related, 1 8.8 CFH CFHR1 CFHR3 CFHR4 CFHR5
31 chronic progressive external ophthalmoplegia 8.0 CFH CFHR1 CFHR3 CFHR5 DGKE THBD

Graphical network of the top 20 diseases related to Hemolytic Uremic Syndrome, Atypical 1:



Diseases related to Hemolytic Uremic Syndrome, Atypical 1

Symptoms & Phenotypes for Hemolytic Uremic Syndrome, Atypical 1

Symptoms via clinical synopsis from OMIM:

54

Hematology:
reticulocytosis
thrombotic microangiopathy
thrombocytopenia
microangiopathic hemolytic anemia
schistocytes
more
Laboratory- Abnormalities:
hyperlipidemia
decreased hemoglobin
increased blood urea nitrogen (bun)
increased creatinine
decreased serum factor h (atypical hus)
more
Cardiovascular- Vascular:
hypertension (especially in atypical hemolytic-uremic syndrome (ahus))

Genitourinary- Kidneys:
acute renal failure
anuria

Neurologic- Central Nervous System:
seizures
coma
hemiparesis
dysphasia
global and focal neurologic abnormalities (less than 30%)
more
Metabolic Features:
fever

Abdomen- Gastroin testinal:
prodrome of gastroenteric diarrhea, usually caused by e. coli 0157-h7 or shigella in young children (typical hus)

Immunology:
complement component consumption
defective complement regulation
activation of the complement system
some patients may have autoantibodies to factor h, resulting in functional factor h deficiency


Clinical features from OMIM:

235400

Human phenotypes related to Hemolytic Uremic Syndrome, Atypical 1:

56 32 (show all 31)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 thrombocytopenia 56 32 hallmark (90%) Very frequent (99-80%) HP:0001873
2 hematuria 56 32 hallmark (90%) Very frequent (99-80%) HP:0000790
3 proteinuria 56 32 hallmark (90%) Very frequent (99-80%) HP:0000093
4 microangiopathic hemolytic anemia 56 32 hallmark (90%) Very frequent (99-80%) HP:0001937
5 decreased serum complement factor i 56 32 frequent (33%) Frequent (79-30%) HP:0005356
6 abnormal lactate dehydrogenase activity 56 32 hallmark (90%) Very frequent (99-80%) HP:0045040
7 acute kidney injury 56 32 hallmark (90%) Very frequent (99-80%) HP:0001919
8 decreased serum complement factor b 56 32 frequent (33%) Frequent (79-30%) HP:0005416
9 decreased level of thrombomodulin 56 32 frequent (33%) Frequent (79-30%) HP:0040229
10 diarrhea 32 HP:0002014
11 cognitive impairment 32 HP:0100543
12 reticulocytosis 32 HP:0001923
13 seizures 32 HP:0001250
14 hemolytic-uremic syndrome 32 HP:0005575
15 hyperlipidemia 32 HP:0003077
16 coma 32 HP:0001259
17 hypertension 32 HP:0000822
18 purpura 32 HP:0000979
19 hemiparesis 32 HP:0001269
20 dysphasia 32 HP:0002357
21 fever 32 HP:0001945
22 anuria 32 HP:0100519
23 decreased serum complement factor h 32 HP:0005369
24 schistocytosis 32 HP:0001981
25 elevated serum creatinine 32 HP:0003259
26 abnormality of metabolism/homeostasis 56 Very frequent (99-80%)
27 abnormality of blood and blood-forming tissues 56 Very frequent (99-80%)
28 complement deficiency 56 Frequent (79-30%)
29 abnormality of complement system 56 Frequent (79-30%)
30 decreased serum complement c3 32 HP:0005421
31 increased blood urea nitrogen 32 HP:0003138

Drugs & Therapeutics for Hemolytic Uremic Syndrome, Atypical 1

Drugs for Hemolytic Uremic Syndrome, Atypical 1 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Complement Inactivating Agents Phase 3
2 Complement System Proteins Phase 3

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Study of ALXN1210 in Children and Adolescents With Atypical Hemolytic Uremic Syndrome (aHUS) Recruiting NCT03131219 Phase 3
2 Single Arm Study of ALXN1210 in Complement Inhibitor Treatment-Naïve Adult and Adolescent Patients With Atypical Hemolytic Uremic Syndrome (aHUS) Recruiting NCT02949128 Phase 3
3 An Open-Label, Multi-Center Clinical Trial of Eculizumab in Pediatric Patients With Atypical Hemolytic-Uremic Syndrome Completed NCT01193348 Phase 2 Eculizumab
4 A Study of an Investigational Drug, Cemdisiran (ALN-CC5), in Patients With Atypical Hemolytic Uremic Syndrome Recruiting NCT03303313 Phase 2 Cemdisiran
5 Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford Recruiting NCT01793168

Search NIH Clinical Center for Hemolytic Uremic Syndrome, Atypical 1

Genetic Tests for Hemolytic Uremic Syndrome, Atypical 1

Genetic tests related to Hemolytic Uremic Syndrome, Atypical 1:

id Genetic test Affiliating Genes
1 Atypical Hemolytic-Uremic Syndrome 1 29
2 Atypical Hemolytic Uremic Syndrome 29
3 Hemolytic Uremic Syndrome, Atypical, Susceptibility to 29
4 Atypical Hemolytic-Uremic Syndrome 24 THBD

Anatomical Context for Hemolytic Uremic Syndrome, Atypical 1

MalaCards organs/tissues related to Hemolytic Uremic Syndrome, Atypical 1:

39
Kidney

Publications for Hemolytic Uremic Syndrome, Atypical 1

Variations for Hemolytic Uremic Syndrome, Atypical 1

UniProtKB/Swiss-Prot genetic disease variations for Hemolytic Uremic Syndrome, Atypical 1:

71 (show all 31)
id Symbol AA change Variation ID SNP ID
1 CFH p.Leu1189Arg VAR_019407
2 CFH p.Ser1191Leu VAR_019408 rs460897
3 CFH p.Arg78Gly VAR_025864
4 CFH p.Cys630Trp VAR_025865
5 CFH p.Glu850Lys VAR_025866
6 CFH p.Gln950His VAR_025867 rs149474608
7 CFH p.Tyr951His VAR_025868
8 CFH p.Thr956Met VAR_025869 rs145975787
9 CFH p.Trp978Cys VAR_025870
10 CFH p.Tyr1021Phe VAR_025871
11 CFH p.Cys1043Arg VAR_025872
12 CFH p.Val1134Gly VAR_025875
13 CFH p.Tyr1142Asp VAR_025876
14 CFH p.Trp1157Arg VAR_025877
15 CFH p.Cys1163Trp VAR_025878
16 CFH p.Trp1183Leu VAR_025879
17 CFH p.Trp1183Arg VAR_025880
18 CFH p.Gly1194Asp VAR_025882
19 CFH p.Val1197Ala VAR_025883 rs460184
20 CFH p.Glu1198Ala VAR_025884
21 CFH p.Arg1215Gly VAR_025886
22 CFH p.Pro1226Ser VAR_025888
23 CFH p.Gln400Lys VAR_031980
24 CFH p.Cys673Tyr VAR_031983
25 CFH p.His893Arg VAR_031984
26 CFH p.Cys915Ser VAR_031985
27 CFH p.Phe1199Ser VAR_031986
28 CFH p.Cys325Tyr VAR_063648
29 CFH p.Val609Ile VAR_063649
30 CFH p.Ile1169Leu VAR_063650
31 CFH p.Trp1183Cys VAR_063651

ClinVar genetic disease variations for Hemolytic Uremic Syndrome, Atypical 1:

6 (show all 27)
id Gene Variation Type Significance SNP ID Assembly Location
1 CFHR1; CFHR3 NC_000001.11: g.(196753076_?)_(?_196839375)del deletion Pathogenic,risk factor GRCh37 Chromosome 1, 196722206: 196808505
2 THBD NM_000361.2(THBD): c.127G> A (p.Ala43Thr) single nucleotide variant risk factor rs1800576 GRCh37 Chromosome 20, 23030015: 23030015
3 C2; CFB NM_001710.5(CFB): c.95G> A (p.Arg32Gln) single nucleotide variant protective rs641153 GRCh37 Chromosome 6, 31914180: 31914180
4 CFH NM_000186.3(CFH): c.3643C> G (p.Arg1215Gly) single nucleotide variant risk factor rs121913051 GRCh37 Chromosome 1, 196716390: 196716390
5 CFH NM_000186.3(CFH): c.3572C> T (p.Ser1191Leu) single nucleotide variant Pathogenic,risk factor rs460897 GRCh37 Chromosome 1, 196716319: 196716319
6 CFH NM_000186.3(CFH): c.3677_*4del24 deletion risk factor rs796052136 GRCh37 Chromosome 1, 196716424: 196716447
7 CFH NM_000186.3(CFH): c.3566T> G (p.Leu1189Arg) single nucleotide variant risk factor rs121913055 GRCh37 Chromosome 1, 196716313: 196716313
8 CFH NM_000186.3(CFH): c.184G> A (p.Val62Ile) single nucleotide variant risk factor rs800292 GRCh37 Chromosome 1, 196642233: 196642233
9 CFH NM_000186.3(CFH): c.83_86delGAAA (p.Arg28Ilefs) deletion risk factor rs796052137 GRCh37 Chromosome 1, 196642132: 196642135
10 CFH NM_000186.3(CFH): c.2697T> A (p.Tyr899Ter) single nucleotide variant risk factor rs121913057 GRCh37 Chromosome 1, 196706705: 196706705
11 CFH NM_000186.3(CFH): c.3628C> T (p.Arg1210Cys) single nucleotide variant Pathogenic,risk factor rs121913059 GRCh37 Chromosome 1, 196716375: 196716375
12 CFH NM_000186.3(CFH): c.3514G> T (p.Glu1172Ter) single nucleotide variant risk factor rs121913060 GRCh37 Chromosome 1, 196716261: 196716261
13 CFH NM_000186.3(CFH): c.3592G> T (p.Glu1198Ter) single nucleotide variant risk factor rs121913063 GRCh37 Chromosome 1, 196716339: 196716339
14 CFH; CFHR1; CFHR3 NC_000001.11 deletion Pathogenic GRCh37 Chromosome 1, 196712876: 196797546
15 CFH NM_000186.3(CFH): c.3590T> C (p.Val1197Ala) single nucleotide variant Pathogenic rs460184 GRCh37 Chromosome 1, 196716337: 196716337
16 BAAT NM_001701.3(BAAT): c.858C> G (p.Ser286=) single nucleotide variant Pathogenic rs80356746 GRCh37 Chromosome 9, 104125109: 104125109
17 BAAT NM_001701.3(BAAT): c.967A> G (p.Ile323Val) single nucleotide variant Pathogenic rs80356747 GRCh37 Chromosome 9, 104125000: 104125000
18 DGKE NM_003647.2(DGKE): c.32C> A (p.Ser11Ter) single nucleotide variant Likely pathogenic,risk factor rs148605410 GRCh37 Chromosome 17, 54912188: 54912188
19 DGKE NM_003647.2(DGKE): c.818G> C (p.Arg273Pro) single nucleotide variant Likely pathogenic,risk factor rs312262695 GRCh37 Chromosome 17, 54925356: 54925356
20 DGKE NM_003647.2(DGKE): c.1000C> T (p.Gln334Ter) single nucleotide variant Likely pathogenic rs312262697 GRCh37 Chromosome 17, 54926168: 54926168
21 DGKE NM_003647.2(DGKE): c.472_473insT (p.Trp158Leufs) insertion Likely pathogenic rs312262698 GRCh37 Chromosome 17, 54921387: 54921387
22 DGKE NM_003647.2(DGKE): c.486dupA (p.Val163Serfs) duplication Likely pathogenic,risk factor rs312262699 GRCh37 Chromosome 17, 54921401: 54921401
23 DGKE NM_003647.2(DGKE): c.889-1G> A single nucleotide variant Likely pathogenic rs312262696 GRCh37 Chromosome 17, 54926056: 54926056
24 DGKE NM_003647.2(DGKE): c.966G> A (p.Trp322Ter) single nucleotide variant Likely pathogenic,risk factor rs138924661 GRCh37 Chromosome 17, 54926134: 54926134
25 C3AR1 NM_004054.3(C3AR1): c.355_356dupGA (p.Asp119Glufs) duplication Likely pathogenic rs869312973 GRCh37 Chromosome 12, 8212426: 8212427
26 CFH NM_000186.3(CFH): c.2950T> C (p.Cys984Arg) single nucleotide variant Likely pathogenic rs886039869 GRCh37 Chromosome 1, 196709916: 196709916
27 CFH NM_000186.3(CFH): c.2397delA (p.Glu800Lysfs) deletion Pathogenic rs1131690796 GRCh38 Chromosome 1, 196728506: 196728506

Copy number variations for Hemolytic Uremic Syndrome, Atypical 1 from CNVD:

7
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 26280 1 198700000 214500000 Deletion CFHR1 Atypical hemolytic uremic syndrome
2 26281 1 198700000 214500000 Deletion CFHR3 Atypical hemolytic uremic syndrome
3 26282 1 198700000 214500000 Deletion CFHR4 Atypical hemolytic uremic syndrome

Expression for Hemolytic Uremic Syndrome, Atypical 1

Search GEO for disease gene expression data for Hemolytic Uremic Syndrome, Atypical 1.

Pathways for Hemolytic Uremic Syndrome, Atypical 1

Pathways related to Hemolytic Uremic Syndrome, Atypical 1 according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
10.75 CFH CFHR3

GO Terms for Hemolytic Uremic Syndrome, Atypical 1

Cellular components related to Hemolytic Uremic Syndrome, Atypical 1 according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 blood microparticle GO:0072562 8.8 CFH CFHR1 CFHR3

Biological processes related to Hemolytic Uremic Syndrome, Atypical 1 according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 complement activation GO:0006956 9.16 CFH CFHR1
2 complement activation, alternative pathway GO:0006957 8.96 CFH CFHR5
3 regulation of complement activation GO:0030449 8.92 CFH CFHR1 CFHR4 CFHR5

Sources for Hemolytic Uremic Syndrome, Atypical 1

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7 CNVD
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16 ExPASy
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34 ICD10 via Orphanet
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37 KEGG
38 LifeMap
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42 MeSH
43 MESH via Orphanet
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