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MCID: HMP007
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Hemophilia malady |
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Sources: 17Genetics Home Reference, 30NIH Rare Diseases, 23MedlinePlus, 2CDC, 44Wikipedia, 22MalaCards See all sources Export this MalaCard |
NIH Rare Diseases:
Hemophilia is a bleeding disorder that slows the blood clotting process. People with this condition experience prolonged bleeding following an injury, surgery, or having a tooth pulled. In severe cases, heavy bleeding occurs after minor trauma or in the absence of injury. Serious complications can result from bleeding into the joints, muscles, brain, or other internal organs. The major types of this condition are hemophilia A and hemophilia B. Although the two types have very similar signs and symptoms, they are caused by mutations in different genes. People with an unusual form of hemophilia B, known as hemophilia B Leyden, experience episodes of excessive bleeding in childhood, but have few bleeding problems after puberty. Another form of the disorder, acquired hemophilia, is not caused by inherited gene mutations.30
MalaCards: Hemophilia, also known as hemophilia a, is related to hemophilia b and acquired hemophilia. An important gene associated with Hemophilia is F8 (coagulation factor VIII, procoagulant component), and among its related pathways are Intrinsic Prothrombin Activation Pathway and RAR-Gamma-RXR-Alpha Degradation. The drugs antihemophilic factor and antihemophilic factor,recombinant and the compounds ivig and hirudin have been mentioned in the context of this disorder. Affiliated tissues include brain, skin and liver, and related mouse phenotypes are respiratory system and renal/urinary system. Genetics Home Reference: Hemophilia is a bleeding disorder that slows the blood clotting process. People with this condition experience prolonged bleeding or oozing following an injury, surgery, or having a tooth pulled. In severe cases of hemophilia, continuous bleeding occurs after minor trauma or even in the absence of injury (spontaneous bleeding). Serious complications can result from bleeding into the joints, muscles, brain, or other internal organs. Milder forms of hemophilia do not necessarily involve spontaneous bleeding, and the condition may not become apparent until abnormal bleeding occurs following surgery or a serious injury.17 MedlinePlus: Hemophilia is a rare inherited disorder in which the blood does not clot normally. about 18,000 people in the u.s. have hemophilia. each year, about 400 babies are born with the disorder. hemophilia usually occurs in males (with very rare exceptions). people who have hemophilia may bleed for a long time after an injury or accident. they also may bleed into their knees, ankles and elbows. bleeding in the joints causes pain and, if not treated, can lead to arthritis. bleeding in the brain, a very serious complication of hemophilia, requires emergency treatment. the main treatment is injecting the missing clotting factor into the bloodstream. nih: national heart, lung, and blood institute23 CDC: Hemophilia is an inherited bleeding disorder in which the blood does not clot properly. People with hemophilia can live full lives and enjoy most of the activities that other people do. If you have hemophilia, or know someone who does, itâs important to learn how to stay as healthy as possible.2 Wikipedia: Haemophilia (pron.: /hiːməˈfɪliə/; also spelled hemophilia in North America, from the Greek haima...44 more... |
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Sources: 2CDC, 43UMLS, 44Wikipedia, 30NIH Rare Diseases, 17Genetics Home Reference, 23MedlinePlus See all sources |
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Sources: 4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT See all sources |
Approved drugs:Search CenterWatch for hemophilia Drug clinical trials:Search ClinicalTrials for hemophilia Search NIH Clinical Center for hemophilia Search CenterWatch for hemophilia Inferred drug relations via UMLS/NDF-RT:43 28 antihemophilic factor, antihemophilic factor,human, antihemophilic factor,human,method m,monoclonal, antihemophilic factor,porcine, antihemophilic factor,recombinant, coagulation factor viii, factor ix,recombinant, factor viia,recombinant, factor viii |
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Sources: 22MalaCards See all sources |
MalaCards organs/tissues related to hemophilia:22Brain, Skin, Liver, Lung, Bone marrow, Whole blood, Heart, Skeletal muscle, Adipocyte, Breast, T cells, B cells, Endothelial
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Sources: 25MGI See all sources |
MGI Mouse Phenotypes related to hemophilia:25 (show all 24)
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Sources: 35PubMed See all sources |
Articles related to hemophilia:(show top 50) (show all 469)
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Sources: 1BioGPS See all sources |
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Sources: 36QIAGEN, 20KEGG, 37R&D Systems, 41Thomson Reuters, 10EMD Millipore See all sources |
Pathways related to hemophilia according to GeneDecks:(show top 50) (show all 75)
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Sources: 32Novoseek , 34PharmGKB, 9DrugBank, 18HMDB, 42Tocris Bioscience See all sources |
Compounds related to hemophilia according to GeneDecks:(show top 50) (show all 344)
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Sources: 12Gene Ontology See all sources |
Cellular components related to hemophilia according to GeneDecks:
Biological processes related to hemophilia according to GeneDecks:(show all 31)
Molecular functions related to hemophilia according to GeneDecks:
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