MCID: HMP004
MIFTS: 66

Hemophilia B malady

Blood category

Summaries for Hemophilia B

Sources:
8Disease Ontology, 43NIH Rare Diseases, 64Wikipedia, 47OMIM, 19GeneReviews, 33MalaCards
See all sources

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NIH Rare Diseases:43 Hemophilia b is a bleeding disorder that slows the blood clotting process. people with this condition experience prolonged bleeding or oozing following an injury or surgery. in severe cases of hemophilia, heavy bleeding occurs after minor trauma or even in the absence of injury. serious complications can result from bleeding into the joints, muscles, brain, or other internal organs. milder forms may not become apparent until abnormal bleeding occurs following surgery or a serious injury. people with an unusual form of hemophilia b, known as hemophilia b leyden, experience episodes of excessive bleeding in childhood but have few bleeding problems after puberty. hemophilia b is inherited in an x-linked recessive pattern and is caused by mutations in the f9 gene. last updated: 6/16/2011

MalaCards: Hemophilia B, also known as factor ix deficiency, is related to amyloidosis and stroke, ischemic. An important gene associated with Hemophilia B is F9 (coagulation factor IX), and among its related pathways are PTM: gamma carboxylation, hypusine formation and arylsulfatase activation and Common Pathway. The drugs recombinant fviia and factor ix,recombinant and the compounds estrogen and dextran sulfate have been mentioned in the context of this disorder. Affiliated tissues include liver, brain and bone marrow, and related mouse phenotypes are cardiovascular system and hematopoietic system.

Disease Ontology:8 An inherited blood coagulation disease that has material basis in factor ix deficiency, which makes coagulation much more prolonged. the disease is inherited as an x-linked recessive trait.

Wikipedia:64 Haemophilia B (or hemophilia B) is a blood clotting disorder caused by a mutation of the Factor IX gene,... more...

Description from OMIM:47 306900

GeneReviews summary for hemo-b

Aliases & Classifications for Hemophilia B

Sources:
8Disease Ontology, 9diseasecard, 19GeneReviews, 43NIH Rare Diseases, 20GeneTests, 22GTR, 47OMIM, 10DISEASES, 45Novoseek, 49Orphanet, 61UMLS, 27ICD9CM, 57SNOMED-CT, 35MeSH, 40NCIt, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Blood


Characteristics (Orphanet epidemiological data):

49
hemophilia b:
Inheritance: X-linked recessive; Prevalence: 1-9/100000; Age of onset: Neonatal/infancy


Aliases & Descriptions:

hemophilia b 8 9 19 43 20 22 47 10 45 49 61
factor ix deficiency 8 19 43 49
christmas disease 19 43
deficiency, functional factor ix 8
congenital factor ix deficiency 8
congenital factor ix disorder 8
hemorrhage 61
hem b 43


External Ids:

Disease Ontology8 DOID:12259
OMIM47 306900
ICD9CM27 286.1
MeSH35 D002836
NCIt40 C26721
MESH via Orphanet36 D002836
ICD10 via Orphanet26 D67
SNOMED-CT via Orphanet58 41788008
UMLS via Orphanet62 C0008533

Related Diseases for Hemophilia B

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Hemophilia B family:

hemophilia hemophilia a, acquired
acquired hemophilia hemophilia a, congenital
severe hemophilia a severe hemophilia b

Diseases related to Hemophilia B via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1174)
idRelated DiseaseScoreTop Affiliating Genes
1amyloidosis30.8F9, F10
2stroke, ischemic30.8F2, F7
3antiphospholipid syndrome30.4F8, F10, PF4, F3, VWF, F2
4systemic lupus erythematosus30.4F8, FBN1, F10, F3, VWF, F2
5factor v deficiency30.4F8, F3, F2
6afibrinogenemia30.3F8, F10, F11, F3, VWF, F2
7acute myocardial infarction30.3CKM, F10, PF4, F7, F3, VWF
8angiodysplasia30.3VWF
9coronary artery disease,30.2F9, FBN1, F10, PF4, F7, F3
10factor x deficiency30.1F9, F10, F7, F3, F2
11sepsis30.1F9, F10, F7, F3, F2, CPB2
12thrombophilia30.1F8, F9, F10, F11, PF4, F2
13factor xii deficiency30.1F3
14cardiac tamponade30.1F8
15vascular disease30.1F8, PF4, F3, VWF
16factor xi deficiency30.1F9, F8, F11, F7, F2, F3
17cadasil30.1F9, F8, F10, F11, PF4, F7
18hepatitis a30.0F2, F8
19hellp syndrome30.0VWF
20acquired immunodeficiency syndrome30.0F8
21aortic aneurysm30.0FBN1
22protein c deficiency30.0F9, F2
23cystic fibrosis30.0F8, F9
24arthropathy30.0F9, F8
25hemarthrosis30.0VWF, F3, F10, F8, F9
26thromboembolism30.0F2, VWF, F3, F7, PF4, F11
27venous thrombosis30.0F2, VWF, F3, PF4, F11, F10
28thrombocytopenia30.0F9, F8, F10, PF4, F7, F3
29arthritis30.0FBN1, F10
30sickle cell disease29.9F9, PF4, VWF
31atherosclerosis29.9HNF4A, FBN1, PF4, F7, F3, VWF
32polycythemia vera29.9PF4
33portal vein thrombosis29.9F2, F8
34hemolytic-uremic syndrome29.9VWF
35coronary thrombosis29.9VWF, F3
36thrombocytosis29.9F10, PF4, F3, VWF, F2
37factor vii deficiency29.9F3, F7, F10, EGF, F8, F9
38vitamin k deficiency hemorrhagic disease29.8F8, F2
39bernard-soulier syndrome29.8F2, VWF, F8, F9
40insulin resistance29.8HNF4A, F9, F8, F7, VWF
41factor viii deficiency29.8CPB2, F2, VWF, F9, F8, F10
42primary pulmonary hypertension29.7FBN1
43dysfibrinogenemia29.7F2
44protein s deficiency29.7F8, F3, F2
45hypercholesterolemia29.6F7, F10, FBN1, F8, F9
46deficiency anemia29.6F2, VWF, F3, F9
47colorectal cancer29.6HNF4A, EGF, PF4, KRT5
48short bowel syndrome29.4EGF
49blood platelet disease29.4F8, F10, VWF
50hepatitis b29.4F2, F8, F9, HNF4A

Graphical network of the top 20 diseases related to Hemophilia B:



Diseases related to hemophilia b

Clinical Features for Hemophilia B

Sources:
47OMIM
See all sources

Clinical features from OMIM:

306900

Clinical synopsis from OMIM:

306900

Drugs & Therapeutics for Hemophilia B

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Hemophilia B

Drug clinical trials:

Search ClinicalTrials for Hemophilia B

Search NIH Clinical Center for Hemophilia B

Search CenterWatch for Hemophilia B

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Hemophilia B

Sources:
20GeneTests, 22GTR
See all sources

Genetic tests related to Hemophilia B:

id Genetic test Affiliating Genes
1 Hemophilia B20 F9
2 Hemophilia B(m)22

Anatomical Context for Hemophilia B

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Hemophilia B:

33
Liver, Brain, Bone marrow, Whole blood, Adipocyte, Breast, T cells, B cells, Endothelial

Animal Models for Hemophilia B or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Hemophilia B:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.2CKM, F9, FBN1, F10, F11, F7
2MP:00053978.1F9, F8, FBN1, F11, PF4, F3
3MP:00053877.9TIMD4, F9, F8, FBN1, EGF, F11
4MP:00107687.2F11, F10, FBN1, F8, F9, HNF4A
5MP:00053766.9CPB2, CKM, HNF4A, F9, F8, FBN1

Publications for Hemophilia B

Sources:
51PubMed
See all sources

Articles related to Hemophilia B:

(show top 50)    (show all 208)
idTitleAuthorsYear
1
Thrombin generation and whole blood viscoelastic assays in the management of hemophilia: current state of art and future perspectives. (23319573)
2013
2
Evaluation and management of bleeding risks with athletic activities in children with hemophilia. (23416863)
2013
3
Barriers and perceived limitations to early treatment of hemophilia. (23700376)
2013
4
The value of usability testing for Internet-based adolescent self-management interventions: "Managing Hemophilia Online". (24094082)
2013
5
Silica-associated connective tissue syndrome with acquired hemophilia (Factor VIII inhibitor), presenting with life-threatening bleed. (24289663)
2013
6
40K glycoPEGylated, recombinant FVIIa: 3-month, double-blind, randomized trial of safety, pharmacokinetics and preliminary efficacy in hemophilia patients with inhibitors. (23578227)
2013
7
The Effectiveness of a New Hemostatic Agent (Ankaferd Blood Stopper) for the Control of Bleeding following Tooth Extraction in Hemophilia: A Controlled Clinical Trial. (24385748)
2013
8
Absence of hematopoietic tissue factor pathway inhibitor mitigates bleeding in mice with hemophilia. (22355108)
2012
9
Gene-based continuous expression of FVIIa for the treatment of hemophilia. (22202061)
2012
10
Management of bleeding in acquired hemophilia A: results from the European Acquired Haemophilia (EACH2) Registry. (22618709)
2012
11
A bispecific antibody to factors IXa and X restores factor VIII hemostatic activity in a hemophilia A model. (23023498)
2012
12
Engineered factor IX variants bypass FVIII and correct hemophilia A phenotype in mice. (22031860)
2012
13
Effect of acute bleeding on daily quality of life assessments in patients with congenital hemophilia with inhibitors and their families: observations from the dosing observational study in hemophilia. (22999142)
2012
14
Inadvertent bleeding in an infant after inguinal hernioplasty leads to diagnosis of hemophilia B. (22113491)
2012
15
Clinical progress in gene therapy: sustained partial correction of the bleeding disorder in patients suffering from severe hemophilia B. (22149214)
2012
16
Role of bone marrow transplantation for correcting hemophilia A in mice. (22368271)
2012
17
Body weight and fat mass index as strong predictors of factor VIII in vivo recovery in adults with hemophilia A. (21729239)
2011
18
Physical functioning in boys with hemophilia in the U.S. (22099359)
2011
19
Tilt balance towards regulation: evolving new strategy for treatment of hemophilia inhibitors. (21649848)
2011
20
Future characteristics of bypassing agents to improve care of hemophilia inhibitor patients: an economic and health-related quality of life perspective. (21831021)
2011
21
Screening for hemophilia A carriers: utility of PCR-RFLP--based polymorphism analysis. (19150994)
2009
22
Comparison of factor VIII transgenes bioengineered for improved expression in gene therapy of hemophilia A. (19222367)
2009
23
Economic evaluation of major knee surgery with recombinant activated factor VII in hemophilia patients with high titer inhibitors and advanced knee arthropathy: exploratory results via literature-based modeling. (18234151)
2008
24
Are chronic hepatitis C viral infections more benign in patients with hemophilia? (17433021)
2007
25
Multiyear therapeutic benefit of AAV serotypes 2, 6, and 8 delivering factor VIII to hemophilia A mice and dogs. (16522813)
2006
26
The safety and efficacy of recombinant human blood coagulation factor IX in previously untreated patients with severe or moderately severe hemophilia B. (15383463)
2005
27
Expression of human coagulation factor VIII in adipocytes transduced with the simian immunodeficiency virus agmTYO1-based vector for hemophilia A gene therapy. (14737084)
2004
28
Acquired hemophilia-A in a patient with multiple sclerosis treated with autologous hematopoietic stem cell transplantation and interferon beta-1a. (15195073)
2004
29
The molecular basis of hemophilia A: genotype-phenotype relationships and inhibitor development. (12640561)
2003
30
Establishment of a hemophilia B transgenic mouse model on the basis of coagulation factor IX gene knock-out mouse]. (12143307)
2002
31
Combined hemophilia A and type 2 von Willebrand's disease: defect of both factor VIII level and factor VIII binding capacity of von Willebrand factor. (11602423)
2001
32
Possible association between cytomegalovirus infection and gastrointestinal bleeding in hemophiliac patients. (10838449)
2000
33
A novel cause of mild/moderate hemophilia A: mutations scattered in the factor VIII C1 domain reduce factor VIII binding to von Willebrand factor. (10910910)
2000
34
Human factor IX corrects the bleeding diathesis of mice with hemophilia B. (9446637)
1998
35
Hemophilia A in the dog: symptoms, blood coagulation analysis and treatment]. (9005837)
1996
36
A method to estimate effects of amino acid substitutions in blood coagulation factor IX from hemophilia B patients. (8591581)
1995
37
Use of prothrombin complex concentrates in management of bleeding in hemophiliacs with inhibitors--benefits and limitations. (7939776)
1994
38
Hemophilia with factor VIII and factor IX inhibitors, incidence, bleeding problems and management. (7886549)
1993
39
Hemophilia A carrier detection by restriction fragment length polymorphism analysis and discriminant analysis based on ELISA of factor VIII and vWf. (1350611)
1992
40
Measurement of basal levels of factor VIIa in hemophilia A and B patients. (1611090)
1992
41
Three distinct point mutations in the factor IX gene of three Japanese CRM+ hemophilia B patients (factor IX BMNagoya 2, factor IX Nagoya 3 and 4). (1871712)
1991
42
Acute HIV-1 infection in patients with hemophilia B treated with beta-propiolactone-UV-inactivated clotting factor. (2125380)
1990
43
Two novel point mutations correlate with an altered developmental expression of blood coagulation factor IX (hemophilia B Leyden phenotype). (2917196)
1989
44
Molecular basis of hemophilia B: a defective enzyme due to an unprocessed propeptide is caused by a point mutation in the factor IX precursor. (3461460)
1986
45
Use of a BamHI polymorphism in the factor IX gene for the determination of hemophilia B carrier status. (3008893)
1986
46
DIC and postoperative wound bleeding under factor IX. Substitution therapy in a case of hemophilia B; sucessful treatment with heparin. (1251344)
1976
47
Double-blind studies on the use of steroids in the treatment of acute hemarthrosis in patients with hemophilia. (4907066)
1970
48
THE LINKAGE RELATIONS OF HEMOPHILIA A AND HEMOPHILIA B (CHRISTMAS DISEASE) TO THE XG BLOOD GROUP SYSTEM. (14097242)
1963
49
Linkage of color blindness to hemophilias A and B. (14006651)
1962
50
Bladder neck obstruction in a 6-month-old hemophiliac infant: successful surgical repair with the aid of fibrinogen rich in factor VIII. (13956727)
1962

Genetic Variations for Hemophilia B

Sources:
63UniProtKB/Swiss-Prot
See all sources

Genetic disease variations for Hemophilia B:

63 (show all 137)
id Symbol AA change Variation SNP ID
1F9p.Ile17AsnVAR_006521
2F9p.Cys28ArgVAR_006522
3F9p.Val30IleVAR_006523
4F9p.Arg43GlnVAR_006524
5F9p.Arg43LeuVAR_006525
6F9p.Arg43TrpVAR_006526
7F9p.Lys45AsnVAR_006527
8F9p.Arg46SerVAR_006528
9F9p.Arg46ThrVAR_006529
10F9p.Asn48IleVAR_006530
11F9p.Ser49ProVAR_006531
12F9p.Glu53AlaVAR_006532
13F9p.Glu54GlyVAR_006533
14F9p.Phe55CysVAR_006534
15F9p.Gly58AlaVAR_006535
16F9p.Gly58ArgVAR_006536
17F9p.Glu66ValVAR_006538
18F9p.Glu67LysVAR_006539
19F9p.Phe71SerVAR_006540
20F9p.Glu73LysVAR_006541
21F9p.Glu73ValVAR_006542
22F9p.Tyr91CysVAR_006543
23F9p.Asp93GlyVAR_006544
24F9p.Gln96ProVAR_006545
25F9p.Cys97SerVAR_006546
26F9p.Pro101ArgVAR_006547
27F9p.Cys102ArgVAR_006548
28F9p.Gly106SerVAR_006549
29F9p.Cys108SerVAR_006550
30F9p.Asp110AsnVAR_006551
31F9p.Ile112SerVAR_006552
32F9p.Asn113LysVAR_006553
33F9p.Tyr115CysVAR_006554
34F9p.Cys119PheVAR_006555
35F9p.Cys119ArgVAR_006556
36F9p.Gly125GluVAR_006557
37F9p.Gly125ValVAR_006558
38F9p.Ile136ThrVAR_006560
39F9p.Gly139AspVAR_006561
40F9p.Gly139SerVAR_006562
41F9p.Cys155PheVAR_006563
42F9p.Gly160GluVAR_006564
43F9p.Gln167HisVAR_006565
44F9p.Cys178ArgVAR_006566
45F9p.Cys178TrpVAR_006567
46F9p.Arg191HisVAR_006568
47F9p.Arg191CysVAR_006569
48F9p.Arg226TrpVAR_006570
49F9p.Arg226GlyVAR_006571
50F9p.Arg226GlnVAR_006572
51F9p.Val227AspVAR_006573
52F9p.Val228LeuVAR_006574
53F9p.Gln241HisVAR_006575
54F9p.Gly253GluVAR_006576
55F9p.Gly253ArgVAR_006577
56F9p.Ala265ThrVAR_006578
57F9p.Ala279ThrVAR_006579
58F9p.Asn283AspVAR_006580
59F9p.Arg294GlyVAR_006582
60F9p.Arg294GlnVAR_006583
61F9p.His302ArgVAR_006584
62F9p.Ile316PheVAR_006585
63F9p.Leu321GlnVAR_006586
64F9p.Pro333HisVAR_006587
65F9p.Thr342LysVAR_006588
66F9p.Thr342MetVAR_006589
67F9p.Gly351AspVAR_006590
68F9p.Trp356CysVAR_006591
69F9p.Gly357GluVAR_006592
70F9p.Lys362GluVAR_006593
71F9p.Gly363TrpVAR_006594
72F9p.Ala366AspVAR_006595
73F9p.Arg379GlyVAR_006596
74F9p.Arg379GlnVAR_006597
75F9p.Cys382TyrVAR_006598
76F9p.Lys387GluVAR_006599
77F9p.Ile390PheVAR_006600
78F9p.Met394LysVAR_006601
79F9p.Cys396SerVAR_006602
80F9p.Arg404ThrVAR_006603
81F9p.Cys407SerVAR_006604
82F9p.Gly413ArgVAR_006605
83F9p.Val419GluVAR_006606
84F9p.Phe424ValVAR_006607
85F9p.Thr426ProVAR_006608
86F9p.Ser430ThrVAR_006609
87F9p.Trp431GlyVAR_006610
88F9p.Trp431ArgVAR_006611
89F9p.Gly432SerVAR_006612
90F9p.Gly432ValVAR_006613
91F9p.Glu433AlaVAR_006614
92F9p.Glu433LysVAR_006615
93F9p.Ala436ValVAR_006616
94F9p.Arg449GlnVAR_006618
95F9p.Arg449TrpVAR_006619
96F9p.Tyr450CysVAR_006620
97F9p.Ile454ThrVAR_006621
98F9p.Arg75GlnVAR_017308
99F9p.Glu79AspVAR_017309
100F9p.Val227PheVAR_017310
101F9p.Val228PheVAR_017311
102F9p.Cys252SerVAR_017312
103F9p.Cys268TrpVAR_017313
104F9p.Glu291ValVAR_017314
105F9p.Asn306SerVAR_017315
106F9p.Gly357ArgVAR_017316
107F9p.Ala397ProVAR_017317
108F9p.Asp410HisVAR_017318
109F9p.Ser411IleVAR_017319
110F9p.Ser411GlyVAR_017320
111F9p.Pro414ThrVAR_017321
112F9p.Gly442ArgVAR_017322
113F9p.Ile443ThrVAR_017323
114F9p.Trp453ArgVAR_017324
115F9p.Cys28TyrVAR_017343
116F9p.Leu52SerVAR_017344
117F9p.Thr84ArgVAR_017345
118F9p.Gly106AspVAR_017346
119F9p.Glu124LysVAR_017347
120F9p.Gly125ArgVAR_017348
121F9p.Cys134TyrVAR_017349
122F9p.Ser169CysVAR_017350
123F9p.Cys170PheVAR_017351
124F9p.Gln241LysVAR_017352
125F9p.Cys252TyrVAR_017353
126F9p.Leu318ArgVAR_017354
127F9p.Pro333ThrVAR_017355
128F9p.Ile344LeuVAR_017356
129F9p.Leu383IleVAR_017357
130F9p.Leu383PheVAR_017358
131F9p.Phe395IleVAR_017359
132F9p.Phe395LeuVAR_017360
133F9p.Cys396PheVAR_017361
134F9p.Cys407ArgVAR_017362
135F9p.Gly412GluVAR_017363
136F9p.Cys435TyrVAR_017364
137F9p.Gly442GluVAR_017365

Expression for genes affiliated with Hemophilia B

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Hemophilia B

Search GEO for disease gene expression data for Hemophilia B.

Pathways for genes affiliated with Hemophilia B

Sources:
54Reactome, 52QIAGEN, 50PharmGKB, 38NCBI BioSystems Database, 53R&D Systems, 30KEGG
See all sources

Pathways related to Hemophilia B according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6F2, F7, F10, F9
2
Hide members
9.6F10, F7, F3, F2
3
Hide members
9.5F9, F10, F7, F3, F2
4
Hide members
9.4CPB2, F2, F7, F10, F9
5
Hide members
9.3F8, EGF, PF4, VWF
6
Hide members
8.9F9, F8, FBN1, F10, F11, F7
7
Hide members
8.8F9, F8, F10, F11, F7, F3
8
Hide members
8.8F9, F8, EGF, F10, F11, PF4
9
Hide members
8.6CPB2, F9, F2, VWF, F3, F7

Compounds for genes affiliated with Hemophilia B

Sources:
45Novoseek, 11DrugBank, 50PharmGKB, 24HMDB, 2BitterDB, 60Tocris Bioscience, 29IUPHAR
See all sources

Compounds related to Hemophilia B according to GeneCards/GeneDecks:

(show top 50)    (show all 142)
idCompoundScoreTop Affiliating Genes
1estrogen4510.3F9, F8
2dextran sulfate4510.2F11, F10, F9
3Gamma-Carboxy-Glutamic Acid1110.2F2, F10, F9
4ecarin4510.1F2, F3, F10
5organon4510.1F9, F10, F3, F2
6coumarins4510.1F9, F10, F3, F2
7tributylphosphate4510.1F9, F8, VWF
8warfarin45 50 11 2413.0VWF, PF4, F9
9rfviii4510.0F9, F8, F10, VWF
10Coagulation factor VIIa1110.0F10, F7, F3
11cardiolipin45 1111.0F10
12kaolin4510.0F9, F8, F10, F3, F2
13spectrozyme4510.0F10, F3, F2
14cacl2459.9F9, F8, FBN1, F10, F3
15hydroxyethyl starch459.9F8, F3, VWF, F2
16ximelagatran45 1110.9F2, F3, F10
17ppack459.9F10, F3, VWF, F2
18Coagulation Factor IX119.9F8, F10, F11, F7, F2
19danaparoid459.9F10, PF4, F3, F2
20tranexamic acid45 1110.8F9, F8, F3, VWF, F2
21protamine sulfate459.8F10, PF4, F3, F2
22polybrene459.8PF4, F3, F2
23fondaparinux459.8F9, F10, PF4, F3, F2
24coumarin45 2 50 2412.7F9, F10, F3, F2
25ristocetin459.7F9, F8, F11, F3, VWF, F2
26desmopressin45 60 29 1112.7F9, F8, F11, F3, VWF, F2
27acetaminophen45 2 50 11 2413.7F9, F8, F10, VWF, F2
28tirofiban45 1110.6F10, PF4, F3, VWF, F2
29abciximab45 1110.5F10, PF4, F3, VWF, F2
30phosphatidylserine45 29 1111.5F9, F8, F10, F3, VWF, F2
31clopidogrel50 45 11 2412.5F10, F3, VWF, F2
32aprotinin45 1110.5F9, F10, F11, PF4, F3, VWF
33homocysteine45 2410.4F9, F8, FBN1, F11, F3, VWF
34heparin45 29 11 2412.3F9, F8, FBN1, F10, F11, PF4
35dermatan sulfate459.3F9, F10, F11, PF4, F3, VWF
36citrate459.2F9, F8, F10, PF4, F3, VWF
37kininogen459.2F9, F11, PF4, F7, F3, VWF
38phospholipid459.2F9, F8, F10, F11, F3, VWF
39aspirin45 50 29 2412.1HNF4A, F8, F10, PF4, F3, VWF
40hirudin459.1F9, F8, F2, VWF, F3, PF4
41aspartate459.0F9, F8, F10, F7, F3, VWF
42lysine459.0HNF4A, F9, F8, FBN1, PF4, KRT5
43gamma-carboxyglutamic acid458.9GFM1, F2, F3, F7, PF4, F10
44serine458.7CKM, HNF4A, F9, F8, FBN1, F10
45creatinine458.7CKM, F9, F8, PF4, F7, F3
46fibrinogen458.6F9, F8, F10, F11, PF4, F7
47alanine458.5HNF4A, F9, F8, FBN1, F10, PF4
48arginine458.4CKM, HNF4A, F9, F8, FBN1, F10
49cysteine458.4CKM, HNF4A, F9, F8, FBN1, EGF
50calcium45 50 11 2410.5CKM, HNF4A, F9, F8, FBN1, EGF

GO Terms for genes affiliated with Hemophilia B

Sources:
16Gene Ontology
See all sources

Cellular components related to Hemophilia B according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intrinsic to external side of plasma membraneGO:0312339.8F3, F10
2endoplasmic reticulum lumenGO:0057889.6F2, F7, F10, F9
3Golgi lumenGO:0057969.5F9, F10, F7, F2
4platelet alpha granule lumenGO:0310939.3F8, EGF, PF4, VWF
5extracellular spaceGO:0056158.4CPB2, F8, FBN1, EGF, F11, PF4
6extracellular regionGO:0055768.1F9, F8, FBN1, EGF, F10, F11

Biological processes related to Hemophilia B according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of platelet-derived growth factor receptor signaling pathwayGO:01064110.1F7, F3
2positive regulation of blood coagulationGO:03019410.0F2, F7
3positive regulation of positive chemotaxisGO:0509279.9F3, F7
4blood coagulation, extrinsic pathwayGO:0075989.9F9, F10, F7, F3
5peptidyl-glutamic acid carboxylationGO:0171879.9F2, F7, F10, F9
6positive regulation of protein kinase B signaling cascadeGO:0518979.8F10, F7, F3
7negative regulation of fibrinolysisGO:0519189.7CPB2, F2
8post-translational protein modificationGO:0436879.7F2, F7, F10, F9
9blood coagulation, intrinsic pathwayGO:0075979.5F9, F8, F10, F11, VWF, F2
10platelet degranulationGO:0025769.4VWF, PF4, EGF, F8
11proteolysisGO:0065089.4F9, F10, F11, F7, F2, CPB2
12platelet activationGO:0301689.3F8, EGF, PF4, VWF, F2
13blood coagulationGO:0075967.9CPB2, HNF4A, F9, F8, EGF, F10

Molecular functions related to Hemophilia B according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase activityGO:0042529.2F2, F7, F11, F10, F9
2calcium ion bindingGO:0055099.1FBN1, EGF, F10, F7, F2, F9

Products for genes affiliated with Hemophilia B

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hemophilia B

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet