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MCID: HMP004
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Hemophilia B malady |
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2 drugs, 20 genes, 7 tissues, 476 related diseases, 5 phenotypes, 123 articles, clinical trials, genetic tests.
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Sources: 6Disease Ontology, 30NIH Rare Diseases, 44Wikipedia, 33OMIM, 15GeneReviews, 22MalaCards See all sources Export this MalaCard |
NIH Rare Diseases: Hemophilia B is a bleeding disorder that slows the blood clotting process. People with this condition experience prolonged bleeding or oozing following an injury or surgery. In severe cases of hemophilia, heavy bleeding occurs after minor trauma or even in the absence of injury. Serious complications can result from bleeding into the joints, muscles, brain, or other internal organs. Milder forms may not become apparent until abnormal bleeding occurs following surgery or a serious injury. People with an unusual form of hemophilia B, known as hemophilia B Leyden, experience episodes of excessive bleeding in childhood but have few bleeding problems after puberty. Hemophilia B is inherited in an X-linked recessive pattern and is caused by mutations in the F9 gene.30
MalaCards: Hemophilia B, also known as factor ix deficiency, is related to hemophilic arthropathy and hemophilia. An important gene associated with Hemophilia B is F9 (coagulation factor IX), and among its related pathways are Gamma-carboxylation of protein precursors and BMAL1:CLOCK/NPAS2 Activates Circadian Expression. The drugs factor ix,recombinant and factor viia,recombinant and the compounds clopidogrel and Gamma-Carboxy-Glutamic Acid have been mentioned in the context of this disorder. Affiliated tissues include brain, skeletal muscle and liver, and related mouse phenotypes are hematopoietic system and immune system. Disease Ontology: An inherited blood coagulation disease that has material basis in factor ix deficiency, which makes coagulation much more prolonged. the disease is inherited as an x-linked recessive trait.6 Wikipedia: Haemophilia B (or hemophilia B) is a blood clotting disorder caused by a mutation of the Factor IX gene,...44 more... OMIM: 306900 GeneReviews summary for hemo-b |
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Sources: 6Disease Ontology, 7diseasecard, 15GeneReviews, 30NIH Rare Diseases, 8DISEASES, 33OMIM, 32Novoseek , 43UMLS, 16GeneTests, 19ICD9CM, 27NCIt, 24MeSH, 40SNOMED-CT See all sources |
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Sources: 33OMIM See all sources |
Clinical features from OMIM: 306900
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Sources: 4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT See all sources |
Approved drugs:Search CenterWatch for hemophilia b Drug clinical trials:Search ClinicalTrials for hemophilia b Search NIH Clinical Center for hemophilia b Search CenterWatch for hemophilia b Inferred drug relations via UMLS/NDF-RT:43 28 factor ix,recombinant, factor viia,recombinant |
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Sources: 16GeneTests See all sources |
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Sources: 22MalaCards See all sources |
MalaCards organs/tissues related to hemophilia b:22Brain, Skeletal muscle, Liver, Skin, T cells, B cells, Endothelial
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Sources: 25MGI See all sources |
MGI Mouse Phenotypes related to hemophilia b:25
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Sources: 35PubMed See all sources |
Articles related to hemophilia b:(show top 50) (show all 123)
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Sources: 1BioGPS See all sources |
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Sources: 38Reactome, 36QIAGEN, 34PharmGKB, 37R&D Systems, 20KEGG See all sources |
Pathways related to hemophilia b according to GeneDecks:
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Sources: 32Novoseek , 34PharmGKB, 9DrugBank, 18HMDB, 42Tocris Bioscience See all sources |
Compounds related to hemophilia b according to GeneDecks:(show top 50) (show all 136)
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Sources: 12Gene Ontology See all sources |
Cellular components related to hemophilia b according to GeneDecks:
Biological processes related to hemophilia b according to GeneDecks:(show all 13)
Molecular functions related to hemophilia b according to GeneDecks:
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