MCID: HMP018
MIFTS: 26

Hemophilic Arthropathy malady

Rare diseases category

Aliases & Classifications for Hemophilic Arthropathy

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Aliases & Descriptions for Hemophilic Arthropathy:

Name: Hemophilic Arthropathy 45 65


Classifications:



Summaries for Hemophilic Arthropathy

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MalaCards based summary: Hemophilic Arthropathy is related to osteoporosis and arthropathy. An important gene associated with Hemophilic Arthropathy is PTGS2 (Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase And Cyclooxygenase)), and among its related pathways are Rheumatoid arthritis and Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway. Affiliated tissues include bone, and related mouse phenotypes are skeleton and limbs/digits/tail.

Related Diseases for Hemophilic Arthropathy

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Diseases related to Hemophilic Arthropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 72)
idRelated DiseaseScoreTop Affiliating Genes
1osteoporosis30.0TNFRSF11A, TNFRSF11B, TNFSF11
2arthropathy11.3
3hemophilia10.7
4hemophilia a10.6
5hemophilia b10.6
6joint disorders10.6
7factor viii deficiency10.6
8osteoarthritis10.5
9hemarthrosis10.5
10greenberg skeletal dysplasia10.4
11arthritis10.4
12cartilage disease10.4
13synovitis10.4
14aneurysm10.4
15pick disease10.2
16leukemia10.2
17coagulation protein disease10.2
18spastic diplegia10.2
19pain disorder10.2
20septic arthritis10.2
21blood coagulation disease10.2
22blood platelet disease10.2
23blood protein disease10.2
24chromosomal disease10.2
25enthesopathy10.2
26inherited blood coagulation disease10.2
27poliomyelitis10.2
28vascular hemostatic disease10.2
29x-linked disease10.2
30factor v leiden thrombophilia10.2
31back pain10.2
32chronic pain10.2
33severe hemophilia a10.2
34severe hemophilia b10.2
35pancreatic acinar cell adenocarcinoma10.1PTGS2, TNFRSF11A
36peripheral nerve schwannoma10.0TNFRSF11A, TNFRSF11B
37sebaceous adenoma10.0PTGS2, TNFSF11
38atrial fibrillation, familial, 810.0TNFRSF11A, TNFSF11
39dyskinesia of esophagus9.9TNFRSF11B, TNFSF11
40pericardial effusion9.9TNFRSF11B, TNFSF11
41pulmonary type ovarian small cell carcinoma9.9TNFRSF11B, TNFSF11
42anterior cruciate ligament tears9.9TNFRSF11B, TNFSF11
43plummer's disease9.8TNFRSF11B, TNFSF11
44ceroid lipofuscinosis, neuronal, 69.8TNFRSF11B, TNFSF11
45ovarian insufficiency, familial9.8TNFRSF11A, TNFSF11
46spondyloarthropathy 19.8TNFRSF11B, TNFSF11
47cholesterol embolism9.8TNFRSF11B, TNFSF11
48familial abdominal aortic aneurysm9.8TNFRSF11B, TNFSF11
49asphyxia neonatorum9.8PTGS2, TNFRSF11A, TNFSF11
50paget disease of bone 2, early-onset9.8TNFRSF11A, TNFRSF11B, TNFSF11

Graphical network of the top 20 diseases related to Hemophilic Arthropathy:



Diseases related to hemophilic arthropathy

Symptoms for Hemophilic Arthropathy

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Drugs & Therapeutics for Hemophilic Arthropathy

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Drugs for Hemophilic Arthropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
TriamcinoloneapprovedPhase 4429124-94-731307
Synonyms:
(8S,9R,10S,11S,13S,14S,16R,17S)-9-fluoro-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
11-beta,16-alpha,17-alpha,21-Tetrahydroxy-9-alpha-fluoro-1,4-pregnadiene-3,20-dione
11.Beta.,16.alpha.,17.alpha., 21-Tetrahydroxy-9.alpha.-fluoro-1,4-pregnadiene-3,20-dione
11.beta.,16.alpha.,17.alpha.,21-Tetrahydroxy-9.alpha.-fluoro-1,4-pregnadiene-3,20-dione
11beta,16alpha,17alpha,21-Tetrahydroxy-9alpha-fluoro-1,4-pregnadiene-3,20-dione
124-94-7
4-08-00-03629 (Beilstein Handbook Reference)
83474-03-7
9-Fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9-Fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9-alpha-Fluoro-11-beta,16-alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9-alpha-Fluoro-16-alpha-hydroxyprednisolone
9.Alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahy
9.Alpha.-Fluoro-11.beta.,16.alpha.,17.alpha., 21-tetrahydroxypregna-1,4-diene-3,20-d
9.alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahydroxy-1,4-pregnadiene-3,20-dione
9.alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9.alpha.-Fluoro-11.beta.,16.alpha.,17.alpha.,21-tetrahydroxypregna-1,4-diene-3,20-dione
9.alpha.-Fluoro-16.alpha.-hydroxyprednisolone
9alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxy-1,4-pregnadiene-3,20-dione
9alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9alpha-Fluoro-11beta,16alpha,17alpha,21-tetrahydroxypregna-1,4-diene-3,20-dione
9alpha-Fluoro-16alpha-hydroxyprednisolone
9α-fluoro-16α-hydroxyprednisolone
AC-2072
AC1L1LDH
AC1Q5HJC
Adcortyl
Allernaze
Aristocort
Aristocort A
Aristocort Tablets
Aristogel
Aristospan
Azmacort
BPBio1_000154
BRD-K77554836-001-03-3
BRN 2341955
BSPBio_000140
Bio-0662
C21H27FO6
CHEMBL1451
CID31307
CL 19823
Celeste
Cinolone
Cinolone-T
D00385
D014221
DB00620
Delphicort
EINECS 204-718-7
EU-0101179
Fluoxiprednisolone
Fluoxyprednisolone
Flutex
Fougera
HMS1568G22
HMS2090D12
HSDB 3194
Kenacort
Kenacort (TN)
Kenacort-A
Kenacort-AG
Kenacort-Ag
Kenalog
Kenalog in Orabase
Kenalog-10
Kenalog-40
Kenalog-H
LS-698
Ledercort
Lopac0_001179
MLS000028542
MLS001066543
 
MLS002695935
MolPort-002-528-981
Mycolog
NCGC00021580-03
NCGC00021580-04
NCGC00021580-05
NCGC00021580-06
NCGC00021580-07
NCI60_000750
NSC 13397
NSC13397
Nasacort
Nasacort Aq
Nasacort Hfa
Omcilon
Omicilon
Oracort
Oralone
Orion
Polcortolon
Pregna-1,4-diene-3,20-dio
Pregna-1,4-diene-3,20-dione, 9-fluoro-11,16,17,21-tetrahydroxy-, (11beta,16alpha)
Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,16alpha,17,21-tetrahydroxy- (8CI)
Prestwick0_000120
Prestwick1_000120
Prestwick2_000120
Prestwick3_000120
Prestwick_438
Rodinolone
S1933_Selleck
SK-Triamcinolone
SMP1_000300
SMR000058333
SPBio_002079
Sk-Triamcinolone
T6376_SIGMA
TRIAMCINOLONE (SEE ALSO TRIAMCINOLONE ACETONIDE (76-25-5) AND TRIAMCINOLONE DIACETATE (67-78-7))
Tiamcinolonum
Tiamcinolonum [INN-Latin]
Tri-Nasal
Triacet
Triacort
Triam-Tablinen
Triamcet
Triamcinalone
Triamcinlon
Triamcinolon
Triamcinolona
Triamcinolona [INN-Spanish]
Triamcinolone (JP15/USP/INN)
Triamcinolone Acetonide
Triamcinolone [USAN:INN:BAN:JAN]
Triamcinolone acetonide
Triamcinolone diacetate
Triamcinolone hexacetonide
Triamcinolonum
Triamcinolonum [INN]
Trianex
Triatex
Tricortale
Triderm
Triesence
Trilone
Tristoject
Trymex
UNII-1ZK20VI6TY
Vetalog
Volon
Volon A
WLN: L E5 B666 OV KU MUTJ A1 BF CQ E1 FV1Q FQ GQ
ZINC03882036
droxypregna-1,4-diene-3,20-dione
ione
nchembio.2007.53-comp7
triamcinolone
2
RopivacaineapprovedPhase 459084057-95-471273, 175805
Synonyms:
(2S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide
(2S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide hydrochloride
(S)-(−)-1-propyl-2',6'-pipecoloxylidide
(S)-ropivacaine
84057-95-4
98717-15-8
AC1L41QM
AC1L41QN
BIDD:GT0203
C07532
C17H26N2O.HCl
CHEBI:8890
CHEMBL1077896
CID175804
CID175805
CPD000469137
D08490
I14-176
L-N-n-propylpipecolic acid-2,6-xylidide
LS-113954
 
MLS001401363
MolPort-003-983-292
NCGC00164597-01
Naropin
Naropin (TN)
ROPIVACAINE HCl
Ropivacaina
Ropivacaina [INN-Spanish]
Ropivacaina [Spanish]
Ropivacaine
Ropivacaine Hydrochloride
Ropivacaine [INN]
Ropivacaine hydrochloride
Ropivacaine monohydrochloride
Ropivacainum
Ropivacainum [INN-Latin]
S-Ropivacaine
SAM001246524
SMR000469137
ST51051452
ropivacaine monohydrochloride,
ropivacaine monohydrochloride, (S)-isomer
3
HyaluronanapprovedPhase 43289067-32-7, 9004-61-953477741, 24759
Synonyms:
Hyaluronate
Hyaluronic acid
Hyaluronic acid sodium salt
Hylartil
Hyruan Plus
Luronit
Macronan
 
Mucoitin
Nutra-HAF
Q 5AQ
Sepracoat
Sepragel Sinus
Sodium hyaluronate
Sofast
Synvisc
4
Bevacizumabapproved, investigationalPhase 41820216974-75-3
Synonyms:
216974-75-3
Avastin
Avastin (TN)
Bevacizumab
Bevacizumab (genetical recombination)
 
Bevacizumab (genetical recombination) (JAN)
D06409
R-435
anti-VEGF monoclonal antibody
antiVEGF
bevacizumab
5Triamcinolone hexacetonidePhase 4429
6Triamcinolone diacetatePhase 4429
7triamcinolone acetonidePhase 4429
8Factor VIIIPhase 4265
9Viscosupplements220
10Coagulants983
11Thrombin257
12Soy BeanNutraceutical427

Interventional clinical trials:

(show all 21)
idNameStatusNCT IDPhase
1Viscosupplementation in Patients With Hemophilic ArthropathyCompletedNCT01748201Phase 4
2Impact of Conservative Treatment by Custom-made Orthoses in Patients With Haemophilic Ankle ArthropathyCompletedNCT00638001Phase 4
3Intra-articular Bevacizumab for Recurrent Hemarthroses at Target Joints With Chronic Hemophilic SynovitisRecruitingNCT02060305Phase 4
4Validation of Ultrasound as a Diagnostic Tool for Assessment of Hemophilic Arthropathy of Knees and AnklesRecruitingNCT01232634Phase 2
5Platelet-Rich Plasma Intra-Articular Injection in Treating Hemophilic ArthropathyCompletedNCT02601170
6Bilateral Deficit Phenomenon in Patients With Haemophilic ArthropathyCompletedNCT02165462
7Manual Therapy in Haemophilic Arthropathy of the KneeCompletedNCT02198014
8Physiotherapy in the Haemophilic Arthropathy of the Elbow.CompletedNCT02198040
9Gait Evaluation in Haemophiliac PatientsCompletedNCT00824798
10Study to Evaluate the Use of Ultrasound in the Diagnosis of Hemophilic Joint DiseaseCompletedNCT00212485
11Epidemiological Study on Haemophilia Care and Orthopaedic Status in Developing CountriesCompletedNCT01503567
12Myofascial Therapy in Patients With Hemophilic ArthropathyRecruitingNCT02433782
13Assessment of Proprioceptive and Functional Characteristics in Patients With HemophiliaRecruitingNCT02165592
14Exploratory Pilot Study of Physical Activity Monitoring in Adult Patients With Haemophilia A by Means of AccelerometryActive, not recruitingNCT02253693
15Joint Outcome Study Continuation for Children With Severe Factor VIII DeficiencyEnrolling by invitationNCT01000844
16Efficacy and Safety of Shea Nut Oil in Hemophilic ArthropathyNot yet recruitingNCT02569359
17Personalized Prophylactic Treatment With Advate® in Severe or Moderate Haemophilia A PatientsNot yet recruitingNCT02622646
18Ultrasonography in Hemophilic Joint Disease and Serum MarkersNot yet recruitingNCT02634918
19Biomechanical Determinants and Patterns Associated to the Pathophysiological Cascade of Ankle Arthropathy in Children With Haemophilia: Non-invasive In-vivo Measurement of Foot Joints in Children With Haemophilia During Gait.Not yet recruitingNCT02229331
20Osteoporosis and MRI Study in HemophiliaTerminatedNCT01460147
21Individually Tailored Prophylaxis in Patients With Severe Hemophilia ATerminatedNCT00995046

Search NIH Clinical Center for Hemophilic Arthropathy

Genetic Tests for Hemophilic Arthropathy

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Anatomical Context for Hemophilic Arthropathy

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MalaCards organs/tissues related to Hemophilic Arthropathy:

33
Bone

Animal Models for Hemophilic Arthropathy or affiliated genes

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MGI Mouse Phenotypes related to Hemophilic Arthropathy:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053907.9COMP, PTGS2, TNFRSF11A, TNFRSF11B, TNFSF11
2MP:00053717.8COMP, HFE, TNFRSF11A, TNFRSF11B, TNFSF11
3MP:00053977.6HFE, PTGS2, TNFRSF11A, TNFRSF11B, TNFSF11
4MP:00053787.0COMP, HFE, PTGS2, TNFRSF11A, TNFRSF11B, TNFSF11
5MP:00053876.8COMP, HFE, PTGS2, TNFRSF11A, TNFRSF11B, TNFSF11

Publications for Hemophilic Arthropathy

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Articles related to Hemophilic Arthropathy:

(show top 50)    (show all 130)
idTitleAuthorsYear
1
Inflammation is key to hemophilic arthropathy. (26542253)
2015
2
The long-term effects of radioactive phosphorous synoviorthesis on hemophilic arthropathy. (25976470)
2015
3
Optimal management of hemophilic arthropathy and hematomas. (25378964)
2014
4
Manual therapy in the treatment of ankle hemophilic arthropathy. A randomized pilot study. (24678758)
2014
5
Viscosupplementation in patients with hemophilic arthropathy. (24453636)
2013
6
RANK-RANKL-OPG in hemophilic arthropathy: from clinical and imaging diagnosis to histopathology. (22753650)
2012
7
Impact of ankle osteoarthritis on the energetics and mechanics of gait: the case of hemophilic arthropathy. (22381586)
2012
8
A long term results of external beam radiation therapy in hemophilic arthropathy of the ankle in children. (21165288)
2010
9
Severe hemophilic arthropathy of the elbow and knee. (17552061)
2007
10
Functional disability in children with hemophilic arthropathy. (16485109)
2006
11
HFE mutations in the pathobiology of hemophilic arthropathy. (15802547)
2005
12
Hemophilic arthropathy of the elbow treated by total elbow replacement. A case series. (14996887)
2004
13
Initiation of degenerative joint damage by experimental bleeding combined with loading of the joint: a possible mechanism of hemophilic arthropathy. (15188380)
2004
14
Total knee arthroplasty in hemophilic arthropathy. (14716652)
2004
15
Periarticular aneurysm following total knee replacement in hemophilic arthropathy. A case report. (14668517)
2003
16
Total knee arthroplasty in hemophilic arthropathy. (12639614)
2003
17
Current treatment of hemophilic arthropathy. (11880733)
2002
18
Hemophilic arthropathy: evaluation of clinical and radiological characteristics and disability. (11105618)
2000
19
Hemophilic arthropathy of the elbow. (8543615)
1995
20
Synoviorthesis with colloidal 32P chromic phosphate for the treatment of hemophilic arthropathy. (8150815)
1994
21
Synovectomy of the ankle for hemophilic arthropathy. (8200887)
1994
22
Utility of magnetic resonance imaging for management of hemophilic arthropathy in children. (8355113)
1993
23
Ultrasound in the diagnosis of the early stages of hemophilic arthropathy of the knee. (1632211)
1992
24
MR imaging in hemophilic arthropathy. (1777491)
1991
25
Radiocolloids in the management of hemophilic arthropathy in children and adolescents. (1997228)
1991
26
Surgical management of advanced hemophilic arthropathy. (2408056)
1990
27
Surgical management of advanced hemophilic arthropathy. An overview of 20 years' experience. (2650951)
1989
28
Roentgenographic classifications of hemophilic arthropathy. Comparison of three systems and correlation with clinical parameters. (2918008)
1989
29
Total knee arthroplasty for the treatment of chronic hemophilic arthropathy. (2805504)
1989
30
Intraarticular methylprednisolone therapy in hemophilic arthropathy. (3354555)
1988
31
Hemophilic arthropathy of the temporomandibular joint: review of the literature, a case report, and discussion. (3278263)
1988
32
Synovectomy of the knee for hemophilic arthropathy. (3805065)
1987
33
Hemophilic arthropathy of the upper limb. (3568484)
1987
34
Hemophilic arthropathy resulting in a locked shoulder. (3955945)
1986
35
Total knee arthroplasty in chronic hemophilic arthropathy. (3714579)
1986
36
Synovectomy in hemophilic arthropathy. A retrospective review of 17 cases. (3955942)
1986
37
A long-term study of hemophilic arthropathy of the knee joint on a program of Factor VIII replacement given at time of each hemarthrosis. (3917602)
1985
38
Hemophilic arthropathy complicated by polyarticular septic arthritis. (6421050)
1984
39
Hemophilic arthropathy: a literature review. (6562449)
1983
40
Nonsteroidal anti-inflammatory drugs in the treatment of hemophilic arthropathy. (7072708)
1982
41
Traumatic aneurysm of the descending geniculate artery: a complication of suction drainage in synovectomy for hemophilic arthropathy. (7428228)
1980
42
Hemophilic arthropathy in the elbow. (302402)
1977
43
Hemophilic arthropathy. Current concepts of pathogenesis and management. (849938)
1977
44
Cartilage in hemophilic arthropathy. Ultrastructural and microanalytical studies. (946396)
1976
45
Biochemical and physiological aspects of degenerative joint diseases with special reference to hemophilic arthropathy. (1053873)
1975
46
Hemophilic arthropathy. (4614656)
1974
47
Hemophilic arthropathy. (6048906)
1967
48
Hemophilic arthropathy. (13775889)
1960
49
Hemophilic arthropathy in dogs. (13836046)
1959
50
Hemophilic arthropathy. (13282597)
1956

Variations for Hemophilic Arthropathy

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Expression for genes affiliated with Hemophilic Arthropathy

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Search GEO for disease gene expression data for Hemophilic Arthropathy.

Pathways for genes affiliated with Hemophilic Arthropathy

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Pathways related to Hemophilic Arthropathy according to GeneCards Suite gene sharing:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.2TNFRSF11A, TNFSF11
2
Show member pathways
9.2TNFRSF11A, TNFSF11
39.0TNFRSF11B, TNFSF11
48.8PTGS2, TNFRSF11A, TNFSF11
58.8PTGS2, TNFRSF11A, TNFSF11
68.6TNFRSF11A, TNFRSF11B, TNFSF11
7
Show member pathways
8.6TNFRSF11A, TNFRSF11B, TNFSF11
88.6TNFRSF11A, TNFRSF11B, TNFSF11
9
TNF Signaling (sino)
Show member pathways
8.6TNFRSF11A, TNFRSF11B, TNFSF11
10
Show member pathways
8.6TNFRSF11A, TNFRSF11B, TNFSF11
118.6TNFRSF11A, TNFRSF11B, TNFSF11
12
Show member pathways
8.2PTGS2, TNFRSF11A, TNFRSF11B, TNFSF11

GO Terms for genes affiliated with Hemophilic Arthropathy

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Cellular components related to Hemophilic Arthropathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:00058878.1HFE, TNFRSF11A, TNFRSF11B, TNFSF11
2extracellular spaceGO:00056158.0COMP, HFE, TNFRSF11B, TNFSF11

Biological processes related to Hemophilic Arthropathy according to GeneCards Suite gene sharing:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1response to tumor necrosis factorGO:003461210.0PTGS2, TNFRSF11A
2positive regulation of fever generation by positive regulation of prostaglandin secretionGO:00718129.8TNFRSF11A, TNFSF11
3TNFSF11-mediated signaling pathwayGO:00718479.8TNFRSF11A, TNFSF11
4positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signalingGO:00718489.8TNFRSF11A, TNFSF11
5monocyte chemotaxisGO:00025489.7TNFRSF11A, TNFSF11
6positive regulation of sequence-specific DNA binding transcription factor activityGO:00510919.7TNFRSF11A, TNFSF11
7response to cytokineGO:00340979.6PTGS2, TNFRSF11A
8osteoclast differentiationGO:00303169.6TNFRSF11A, TNFSF11
9response to radiationGO:00093149.3PTGS2, TNFRSF11A
10response to lipopolysaccharideGO:00324969.3PTGS2, TNFRSF11A, TNFRSF11B
11mammary gland alveolus developmentGO:00607499.2TNFRSF11A, TNFSF11
12inflammatory responseGO:00069549.2PTGS2, TNFRSF11A, TNFRSF11B
13ossificationGO:00015039.1TNFRSF11A, TNFSF11
14tumor necrosis factor-mediated signaling pathwayGO:00332099.0TNFRSF11A, TNFRSF11B, TNFSF11
15immune responseGO:00069558.6HFE, TNFRSF11B, TNFSF11

Molecular functions related to Hemophilic Arthropathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor-activated receptor activityGO:00050319.4TNFRSF11A, TNFRSF11B

Sources for Hemophilic Arthropathy

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet