MCID: HMP018
MIFTS: 34

Hemophilic Arthropathy malady

Categories: Rare diseases

Aliases & Classifications for Hemophilic Arthropathy

Aliases & Descriptions for Hemophilic Arthropathy:

Name: Hemophilic Arthropathy 50 69

Classifications:



Summaries for Hemophilic Arthropathy

MalaCards based summary : Hemophilic Arthropathy is related to arthropathy and hemophilia. An important gene associated with Hemophilic Arthropathy is HFE (Hemochromatosis), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Development Endothelin-1/EDNRA signaling. The drugs Bevacizumab and Hyaluronic acid have been mentioned in the context of this disorder. Affiliated tissues include bone, and related phenotypes are growth/size/body region and behavior/neurological

Related Diseases for Hemophilic Arthropathy

Diseases related to Hemophilic Arthropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 55)
id Related Disease Score Top Affiliating Genes
1 arthropathy 10.9
2 hemophilia 10.1
3 listeria meningitis 10.1 HFE TNFRSF11B
4 cocaine dependence 10.0 TNFRSF11A TNFRSF11B
5 patellofemoral pain syndrome 10.0 PTGS2 TNFRSF11A
6 osteoporosis 10.0
7 osteoarthritis 10.0
8 aneurysm 10.0
9 cortical blindness 10.0 TNFRSF11B TNFSF11
10 peripheral scars of retina 10.0 TNFRSF11B TNFSF11
11 respiratory system disease 10.0 PTGS2 TNFRSF11B
12 breast intracanalicular fibroadenoma 9.9 PTGS2 TNFSF11
13 acrorenal syndrome 9.9 TNFRSF11B TNFSF11
14 extrahepatic bile duct leiomyosarcoma 9.9 TNFRSF11A TNFSF11
15 statin toxicity 9.9 PTGS2 TNFSF11
16 exudative vitreoretinopathy 4 9.9 TNFRSF11B TNFSF11
17 post-traumatic stress disorder 9.9 TNFRSF11B TNFSF11
18 chromosome 16q22 deletion syndrome 9.9 TNFRSF11A TNFSF11
19 celiac disease 9.9 TNFRSF11B TNFSF11
20 vascular dementia 9.9 TNFRSF11B TNFSF11
21 ceroid lipofuscinosis, neuronal, kufs type, adult onset 9.8 TNFRSF11B TNFSF11
22 hemophilia a 9.8
23 arthritis 9.8
24 leukemia 9.8
25 poliomyelitis 9.8
26 hemarthrosis 9.8
27 septic arthritis 9.8
28 synovium cancer 9.8 COMP TNFRSF11B TNFSF11
29 molybdenum cofactor deficiency a 9.8 COMP TNFRSF11B TNFSF11
30 phka2-related phosphorylase kinase deficiency 9.8 TNFRSF11A TNFRSF11B TNFSF11
31 birk-barel mental retardation dysmorphism syndrome 9.8 TNFRSF11A TNFRSF11B TNFSF11
32 osteopetrosis, autosomal recessive 7 9.8 TNFRSF11A TNFRSF11B TNFSF11
33 pancreatic ductal adenocarcinoma 9.8 TNFRSF11A TNFSF11
34 epilepsy, idiopathic generalized 14 9.8 TNFRSF11A TNFRSF11B TNFSF11
35 polyomavirus allograft nephropathy 9.8 TNFRSF11A TNFRSF11B TNFSF11
36 microcephaly 10, primary, autosomal recessive 9.8 TNFRSF11A TNFRSF11B TNFSF11
37 maroteaux stanescu cousin syndrome 9.8 TNFRSF11A TNFRSF11B TNFSF11
38 bronchus cancer 9.7 TNFRSF11A TNFRSF11B TNFSF11
39 bulbomembranous urethral cancer 9.7 TNFRSF11A TNFRSF11B TNFSF11
40 glossitis 9.7 TNFRSF11A TNFRSF11B TNFSF11
41 chromosomal disease 9.7 TNFRSF11A TNFRSF11B TNFSF11
42 dysbaric osteonecrosis 9.7 TNFRSF11A TNFRSF11B TNFSF11
43 ischemic bone disease 9.7 TNFRSF11A TNFRSF11B TNFSF11
44 preretinal fibrosis 9.7 TNFRSF11A TNFRSF11B TNFSF11
45 intrahepatic cholestasis 9.7 TNFRSF11A TNFRSF11B TNFSF11
46 bladder papillary transitional cell neoplasm 9.7 TNFRSF11A TNFRSF11B TNFSF11
47 histiocytosis 9.7 TNFRSF11A TNFRSF11B TNFSF11
48 fungal gastritis 9.7 TNFRSF11B TNFSF11
49 autistic disorder 9.7 PTGS2 TNFRSF11A TNFSF11
50 carnitine deficiency, systemic primary 9.7 TNFRSF11A TNFRSF11B TNFSF11

Graphical network of the top 20 diseases related to Hemophilic Arthropathy:



Diseases related to Hemophilic Arthropathy

Symptoms & Phenotypes for Hemophilic Arthropathy

MGI Mouse Phenotypes related to Hemophilic Arthropathy:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.85 COMP HFE PTGS2 TNFRSF11A TNFRSF11B TNFSF11
2 behavior/neurological MP:0005386 9.8 TNFSF11 COMP HFE PTGS2 TNFRSF11A
3 immune system MP:0005387 9.73 HFE PTGS2 TNFRSF11A TNFRSF11B TNFSF11 COMP
4 hematopoietic system MP:0005397 9.72 HFE PTGS2 TNFRSF11A TNFRSF11B TNFSF11
5 limbs/digits/tail MP:0005371 9.55 COMP HFE TNFRSF11A TNFRSF11B TNFSF11
6 no phenotypic analysis MP:0003012 9.26 HFE PTGS2 TNFRSF11A TNFSF11
7 skeleton MP:0005390 9.02 COMP PTGS2 TNFRSF11A TNFRSF11B TNFSF11

Drugs & Therapeutics for Hemophilic Arthropathy

Drugs for Hemophilic Arthropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 4 216974-75-3
2
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741 24759
3
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
4
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
5 Angiogenesis Inhibitors Phase 4
6 Angiogenesis Modulating Agents Phase 4
7 triamcinolone acetonide Phase 4
8 Factor VIII Phase 4
9 Adjuvants, Immunologic Phase 4
10 Triamcinolone diacetate Phase 4
11 Triamcinolone hexacetonide Phase 4
12 Viscosupplements Phase 4
13 Hylan Phase 4
14 Protective Agents Phase 4
15 Coagulants
16 Thrombin
17 Hemostatics
18 Soy Bean Nutraceutical

Interventional clinical trials:

(show all 26)
id Name Status NCT ID Phase
1 Intra-articular Bevacizumab for Recurrent Hemarthroses at Target Joints With Chronic Hemophilic Synovitis Unknown status NCT02060305 Phase 4
2 Viscosupplementation in Patients With Hemophilic Arthropathy Completed NCT01748201 Phase 4
3 Impact of Conservative Treatment by Custom-made Orthoses in Patients With Haemophilic Ankle Arthropathy Completed NCT00638001 Phase 4
4 Validation of Ultrasound as a Diagnostic Tool for Assessment of Hemophilic Arthropathy of Knees and Ankles Completed NCT01232634 Phase 2
5 A Proof-of-Concept Study of AC-201 Controlled-Release Tablet (CR Tablet) in Patients With Hemophilic Arthropathy Recruiting NCT02994147 Phase 2
6 Biomechanical Determinants and Patterns Associated to the Pathophysiological Cascade of Ankle Arthropathy in Children With Haemophilia: Non-invasive In-vivo Measurement of Foot Joints in Children With Haemophilia During Gait. Unknown status NCT02229331
7 Platelet-Rich Plasma Intra-Articular Injection in Treating Hemophilic Arthropathy Completed NCT02601170
8 Bilateral Deficit Phenomenon in Patients With Haemophilic Arthropathy Completed NCT02165462
9 Manual Therapy in Haemophilic Arthropathy of the Knee Completed NCT02198014
10 Physiotherapy in the Haemophilic Arthropathy of the Elbow. Completed NCT02198040
11 Gait Evaluation in Haemophiliac Patients Completed NCT00824798
12 Exploratory Pilot Study of Physical Activity Monitoring in Adult Patients With Haemophilia A by Means of Accelerometry Completed NCT02253693
13 Educational Physiotherapy in Haemophilia Completed NCT02825706
14 Study to Evaluate the Use of Ultrasound in the Diagnosis of Hemophilic Joint Disease Completed NCT00212485
15 Epidemiological Study on Haemophilia Care and Orthopaedic Status in Developing Countries Completed NCT01503567
16 Myofascial Therapy in Patients With Hemophilic Arthropathy Recruiting NCT02433782
17 Efficacy and Safety of Shea Nut Oil in Hemophilic Arthropathy Recruiting NCT02569359
18 TGA (Thrombin Generation Assay) and Prophylaxis in Haemophilia Recruiting NCT02781766
19 Assessment of Proprioceptive and Functional Characteristics in Patients With Hemophilia Recruiting NCT02165592
20 Personalized Prophylactic Treatment With Advate® in Severe or Moderate Haemophilia A Patients Recruiting NCT02622646
21 Ultrasonography in Hemophilic Joint Disease and Serum Markers Recruiting NCT02634918
22 Joint Outcome Study Continuation for Children With Severe Factor VIII Deficiency Enrolling by invitation NCT01000844
23 Effectiveness of the Myofascial Therapy in the Hemophilic Arthropathy of Ankle Not yet recruiting NCT02825667
24 Fascial Therapy in Elbow Hemophilic Arthropathy Not yet recruiting NCT03009591
25 Osteoporosis and MRI Study in Hemophilia Terminated NCT01460147
26 Individually Tailored Prophylaxis in Patients With Severe Hemophilia A Terminated NCT00995046

Search NIH Clinical Center for Hemophilic Arthropathy

Genetic Tests for Hemophilic Arthropathy

Anatomical Context for Hemophilic Arthropathy

MalaCards organs/tissues related to Hemophilic Arthropathy:

39
Bone

Publications for Hemophilic Arthropathy

Articles related to Hemophilic Arthropathy:

(show top 50) (show all 142)
id Title Authors Year
1
Pathophysiology of hemophilic arthropathy and potential targets for therapy. ( 27890816 )
2017
2
Intra-articular injections of mesenchymal stem cells (MSCs) as a treatment for hemophilic arthropathy. ( 27322636 )
2016
3
Soluble vascular cell adhesion molecular-1 is a potential biological indicator of hemophilic arthropathy. ( 27861372 )
2016
4
Advances and challenges in hemophilic arthropathy. ( 26805902 )
2016
5
The F8(-/-) rat as a model of hemophilic arthropathy. ( 27060449 )
2016
6
Synovium and cartilage biomarkers in hemophilic arthropathy. ( 26761216 )
2016
7
Altered collagen turnover in factor VIII-deficient rats with hemophilic arthropathy identifies potential novel serological biomarkers in hemophilia. ( 27681457 )
2016
8
Assessment of Hemophilic Arthropathy by Ultrasound: Where Do We Stand? ( 27124619 )
2016
9
Radiosynoviorthesis in hemophilic arthropathy: pathologic blood pool imaging on pre-therapeutic bone scintigraphy is not a predictor of treatment success. ( 27796541 )
2016
10
Total ankle replacement or ankle fusion in painful advanced hemophilic arthropathy of the ankle. ( 26358145 )
2015
11
Vascular remodeling underlies rebleeding in hemophilic arthropathy. ( 26257191 )
2015
12
Subjective results of joint lavage and viscosupplementation in hemophilic arthropathy. ( 26207096 )
2015
13
The long-term effects of radioactive phosphorous synoviorthesis on hemophilic arthropathy. ( 25976470 )
2015
14
Hemophilic arthropathy of the elbow: prophylaxis, imaging, and the role of invasiveA management. ( 26385390 )
2015
15
Patient dissatisfaction after total knee arthroplasty for hemophilic arthropathy and osteoarthritis (non-hemophilia patients). ( 26561009 )
2015
16
Total Knee Arthroplasty in Hemophilic Arthropathy. ( 26665252 )
2015
17
Diagnostic accuracy of ultrasound for assessment of hemophilic arthropathy: MRI correlation. ( 25714320 )
2015
18
Inflammation is key to hemophilic arthropathy. ( 26542253 )
2015
19
Manual therapy in the treatment of ankle hemophilic arthropathy. A randomized pilot study. ( 24678758 )
2014
20
Osteoid osteoma of the elbow mimicking hemophilic arthropathy. ( 24749122 )
2014
21
Optimal management of hemophilic arthropathy and hematomas. ( 25378964 )
2014
22
The Effectiveness of Tools for Monitoring Hemophilic Arthropathy. ( 25000469 )
2014
23
Hemophilic arthropathy: a review of imaging and staging. ( 24332203 )
2013
24
Outcome of Total Knee Arthroplasty in Hemophilic Arthropathy. ( 23958233 )
2013
25
Viscosupplementation in patients with hemophilic arthropathy. ( 24453636 )
2013
26
Hemophilic arthropathy of shoulder joints: clinical, radiographic, and ultrasonographic characteristics of seventy patients. ( 23553306 )
2013
27
Arthroscopic ankle arthrodesis in hemophilic arthropathy. ( 23478887 )
2013
28
Outcome of total knee arthroplasty combined patelloplasty for end-stage type A hemophilic arthropathy. ( 21342764 )
2012
29
Impact of ankle osteoarthritis on the energetics and mechanics of gait: the case of hemophilic arthropathy. ( 22381586 )
2012
30
RANK-RANKL-OPG in hemophilic arthropathy: from clinical and imaging diagnosis to histopathology. ( 22753650 )
2012
31
Intra-articular injection of mesenchymal stem cells expressing coagulation factor ameliorates hemophilic arthropathy in factorA VIII-deficient mice. ( 22784361 )
2012
32
Total knee arthroplasty in a patient with hemophilic arthropathy and high-titer inhibitors: a cost analysis. ( 22153945 )
2012
33
Osteoporosis/osteopenia and hemophilic arthropathy in severe hemophilic patients. ( 22292576 )
2012
34
Hemophilic arthropathy in patients with von Willebrand disease. ( 23010260 )
2012
35
Shoulder arthroplasty in hemophilic arthropathy. ( 21167746 )
2011
36
Arthroscopic ankle arthrodesis for hemophilic arthropathy: two cases report. ( 21295463 )
2011
37
Evaluation of osteoporosis in hemophilic arthropathy patients: correlation with disease severity and serum trace minerals. ( 22007335 )
2011
38
The efficacy of magnetic resonance imaging and x-ray in the evaluation of response to radiosynovectomy in patients with hemophilic arthropathy. ( 23487524 )
2011
39
Hemophilic arthropathy of the elbow. ( 21501786 )
2011
40
Synoviorthesis induced by rifampicin in hemophilic arthropathy: a report of 24 treated joints. ( 21318571 )
2011
41
Unraveling hemophilic arthropathy. ( 21350060 )
2011
42
End-stage hemophilic arthropathy in a patient from a developing nation. ( 20808176 )
2010
43
Hemophilic arthropathy. ( 21623422 )
2010
44
Increased bone resorption is implicated in the pathogenesis of bone loss in hemophiliacs: correlations with hemophilic arthropathy and HIV infection. ( 19488753 )
2010
45
Blood-induced joint disease: the pathophysiology of hemophilic arthropathy. ( 20586922 )
2010
46
A long term results of external beam radiation therapy in hemophilic arthropathy of the ankle in children. ( 21165288 )
2010
47
Effects of electrical stimulation on muscle trophism in patients with hemophilic arthropathy. ( 19887218 )
2009
48
Total knee arthroplasty in hemophilic arthropathy: efficiency of clotting factor usage in multijoint procedures. ( 19682237 )
2009
49
The combination of the biomarkers urinary C-terminal telopeptide of type II collagen, serum cartilage oligomeric matrix protein, and serum chondroitin sulfate 846 reflects cartilage damage in hemophilic arthropathy. ( 19116938 )
2009
50
Rhenium-186 hydroxyethylidenediphosphonate (186Re HEDP) for the treatment of hemophilic arthropathy: first results. ( 17710012 )
2007

Variations for Hemophilic Arthropathy

Expression for Hemophilic Arthropathy

Search GEO for disease gene expression data for Hemophilic Arthropathy.

Pathways for Hemophilic Arthropathy

Pathways related to Hemophilic Arthropathy according to GeneCards Suite gene sharing:

(show all 13)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.87 PTGS2 TNFRSF11A TNFRSF11B TNFSF11
2
Show member pathways
12.37 TNFRSF11A TNFRSF11B TNFSF11
3
Show member pathways
12.18 TNFRSF11A TNFRSF11B TNFSF11
4 12.1 PTGS2 TNFRSF11A TNFSF11
5 11.65 TNFRSF11A TNFRSF11B TNFSF11
6
Show member pathways
11.65 PTGS2 TNFRSF11A TNFRSF11B TNFSF11
7 11.48 TNFRSF11A TNFSF11
8 11.48 PTGS2 TNFRSF11A TNFSF11
9
Show member pathways
11.36 TNFRSF11A TNFSF11
10
Show member pathways
11.36 TNFRSF11A TNFRSF11B TNFSF11
11 10.99 TNFRSF11A TNFRSF11B TNFSF11
12 10.55 TNFRSF11B TNFSF11
13 10 TNFRSF11A TNFRSF11B TNFSF11

GO Terms for Hemophilic Arthropathy

Cellular components related to Hemophilic Arthropathy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.26 COMP HFE TNFRSF11B TNFSF11
2 integral component of plasma membrane GO:0005887 8.92 HFE TNFRSF11A TNFRSF11B TNFSF11

Biological processes related to Hemophilic Arthropathy according to GeneCards Suite gene sharing:

(show all 15)
id Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.67 PTGS2 TNFRSF11A TNFRSF11B
2 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.55 TNFRSF11A TNFSF11
3 ossification GO:0001503 9.54 TNFRSF11A TNFSF11
4 response to lipopolysaccharide GO:0032496 9.54 PTGS2 TNFRSF11A TNFRSF11B
5 apoptotic signaling pathway GO:0097190 9.52 TNFRSF11A TNFRSF11B
6 response to cytokine GO:0034097 9.51 PTGS2 TNFRSF11A
7 monocyte chemotaxis GO:0002548 9.48 TNFRSF11A TNFSF11
8 response to radiation GO:0009314 9.46 PTGS2 TNFRSF11A
9 response to tumor necrosis factor GO:0034612 9.43 PTGS2 TNFRSF11A
10 tumor necrosis factor-mediated signaling pathway GO:0033209 9.43 TNFRSF11A TNFRSF11B TNFSF11
11 osteoclast differentiation GO:0030316 9.4 TNFRSF11A TNFSF11
12 mammary gland alveolus development GO:0060749 9.32 TNFRSF11A TNFSF11
13 TNFSF11-mediated signaling pathway GO:0071847 9.16 TNFRSF11A TNFSF11
14 positive regulation of fever generation by positive regulation of prostaglandin secretion GO:0071812 8.96 TNFRSF11A TNFSF11
15 positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling GO:0071848 8.62 TNFRSF11A TNFSF11

Molecular functions related to Hemophilic Arthropathy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor-activated receptor activity GO:0005031 8.62 TNFRSF11A TNFRSF11B

Sources for Hemophilic Arthropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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