MCID: HMP018
MIFTS: 33

Hemophilic Arthropathy malady

Summaries for Hemophilic Arthropathy

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33MalaCards
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MalaCards: Hemophilic Arthropathy is related to arthropathy and osteoporosis. An important gene associated with Hemophilic Arthropathy is COMP (cartilage oligomeric matrix protein), and among its related pathways are Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway and Osteoblast Signaling. The compounds glucose and acetaminophen have been mentioned in the context of this disorder. Related mouse phenotypes are limbs/digits/tail and liver/biliary system.

Aliases & Classifications for Hemophilic Arthropathy

Sources:
43NIH Rare Diseases, 61UMLS
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Aliases & Descriptions:

hemophilic arthropathy 43 61


Related Diseases for Hemophilic Arthropathy

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Hemophilic Arthropathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 90)
idRelated DiseaseScoreTop Affiliating Genes
1arthropathy31.8COMP, F8, HFE, F9, TNFRSF11B, TNFSF11
2osteoporosis30.5TNFRSF11A, TNFRSF11B, TNFSF11
3hemarthrosis30.2F8, F9
4hemophilia b30.2F9, F8
5osteoarthritis30.2TNFRSF11B, PTGS2, TNFSF11, COMP, TNFRSF11A, HFE
6arthritis30.2TNFRSF11A, TNFSF11, PTGS2, COMP, HFE, TNFRSF11B
7hemophilia10.5
8septic arthritis10.2
9severe hemophilia a10.2
10chondrosarcoma10.0COMP
11paget's disease of bone10.0TNFRSF11A
12galactosemia10.0HFE
13factor xii deficiency10.0F9
14wilson disease10.0HFE
15coronary heart disease10.0HFE
16root resorption10.0TNFRSF11B
17sickle cell disease10.0F9
18hypogonadism10.0HFE
19acute myocardial infarction10.0TNFSF11
20thalassemia10.0HFE
21lung cancer10.0PTGS2
22bladder carcinoma10.0F9
23hemorrhagic disease10.0F9
24protein c deficiency10.0F9
25periapical granuloma10.0TNFSF11
26renal osteodystrophy10.0TNFRSF11B
27obesity10.0COMP, HFE
28anorexia nervosa10.0TNFRSF11B
29factor v deficiency10.0F8
30myelofibrosis10.0F8
31cardiac tamponade10.0F8
32colorectal cancer10.0PTGS2
33sarcoma10.0F8
34multiple myeloma10.0TNFSF11, TNFRSF11B
35cholesteatoma10.0TNFSF11, TNFRSF11B
36osteosclerosis10.0TNFRSF11B, TNFSF11
37melanoma10.0TNFSF11, TNFRSF11B
38thromboembolism10.0F8, F9
39aortic valve stenosis10.0TNFSF11, TNFRSF11B
40thrombophilia10.0F9, F8
41factor xi deficiency10.0F9, F8
42adenoameloblastoma10.0TNFSF11, TNFRSF11B
43factor vii deficiency10.0F8, F9
44diabetes mellitus10.0F8, HFE
45factor viii deficiency10.0F9, F8
46ankylosing spondylitis10.0TNFRSF11B, TNFSF11
47bernard-soulier syndrome10.0F8, F9
48pain agnosia10.0PTGS2, F9
49viral hepatitis10.0HFE, F8
50glanzmann's thrombasthenia10.0F8, F9

Graphical network of the top 20 diseases related to Hemophilic Arthropathy:



Diseases related to hemophilic arthropathy

Clinical Features for Hemophilic Arthropathy

Drugs & Therapeutics for Hemophilic Arthropathy

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Hemophilic Arthropathy

Drug clinical trials:

Search ClinicalTrials for Hemophilic Arthropathy

Search NIH Clinical Center for Hemophilic Arthropathy

Search CenterWatch for Hemophilic Arthropathy

Genetic Tests for Hemophilic Arthropathy

Anatomical Context for Hemophilic Arthropathy

Animal Models for Hemophilic Arthropathy or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Hemophilic Arthropathy

Sources:
51PubMed
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Articles related to Hemophilic Arthropathy:

(show top 50)    (show all 119)
idTitleAuthorsYear
1
Outcome of Total Knee Arthroplasty in Hemophilic Arthropathy. (23958233)
2013
2
Impact of ankle osteoarthritis on the energetics and mechanics of gait: the case of hemophilic arthropathy. (22381586)
2012
3
Osteoporosis/osteopenia and hemophilic arthropathy in severe hemophilic patients. (22292576)
2012
4
Synoviorthesis induced by rifampicin in hemophilic arthropathy: a report of 24 treated joints. (21318571)
2011
5
Evaluation of osteoporosis in hemophilic arthropathy patients: correlation with disease severity and serum trace minerals. (22007335)
2011
6
Unraveling hemophilic arthropathy. (21350060)
2011
7
The efficacy of magnetic resonance imaging and x-ray in the evaluation of response to radiosynovectomy in patients with hemophilic arthropathy. (23487524)
2011
8
Shoulder arthroplasty in hemophilic arthropathy. (21167746)
2011
9
A long term results of external beam radiation therapy in hemophilic arthropathy of the ankle in children. (21165288)
2010
10
The combination of the biomarkers urinary C-terminal telopeptide of type II collagen, serum cartilage oligomeric matrix protein, and serum chondroitin sulfate 846 reflects cartilage damage in hemophilic arthropathy. (19116938)
2009
11
Effects of electrical stimulation on muscle trophism in patients with hemophilic arthropathy. (19887218)
2009
12
Rhenium-186 hydroxyethylidenediphosphonate (186Re HEDP) for the treatment of hemophilic arthropathy: first results. (17710012)
2007
13
Hemophilic arthropathy in non-severe hemophiliacs. (17047956)
2007
14
Functional disability in children with hemophilic arthropathy. (16485109)
2006
15
HFE mutations in the pathobiology of hemophilic arthropathy. (15802547)
2005
16
Total knee arthroplasty in hemophilic arthropathy. (15660074)
2005
17
Leukemia and P32 radionuclide synovectomy for hemophilic arthropathy. (15978117)
2005
18
Periarticular aneurysm following total knee replacement in hemophilic arthropathy. A case report. (14668517)
2003
19
Radiological evaluation of hemophilic arthropathy. (12640564)
2003
20
Current treatment of hemophilic arthropathy. (11880733)
2002
21
Hemophilic arthropathy: evaluation of clinical and radiological characteristics and disability. (11105618)
2000
22
Depression in children with hemophilic arthropathy and poliomyelitis: a preliminary report. (10731865)
2000
23
Knee arthroplasty in hemophilic arthropathy. (10101322)
1999
24
Hemophilic arthropathy of the elbow. (8543615)
1995
25
Hip arthroplasty in hemophilic arthropathy. (7782355)
1995
26
Synovectomy of the ankle for hemophilic arthropathy. (8200887)
1994
27
Utility of magnetic resonance imaging for management of hemophilic arthropathy in children. (8355113)
1993
28
Prophylaxis with factor concentrates in preventing hemophilic arthropathy. (1793153)
1991
29
Surgical management of advanced hemophilic arthropathy. (2408056)
1990
30
Synovectomy of the knee for hemophilic arthropathy. (3805065)
1987
31
Hemophilic arthropathy of the upper limb. (3568484)
1987
32
Hemophilic arthropathy: assessment with MR imaging. (3615876)
1987
33
Magnetic resonance imaging in hemophilic arthropathy of the knee. (2960359)
1987
34
Isometric exercise for an individual with hemophilic arthropathy. (3628490)
1987
35
Total knee arthroplasty in chronic hemophilic arthropathy. (3714579)
1986
36
Synovectomy of the knee for hemophilic arthropathy. (3944160)
1986
37
Early pathogenesis of hemophilic arthropathy. Evolution of the subchondral cyst. (6705390)
1984
38
Hemophilic arthropathy--an immunologic study of the synovium. (6382587)
1984
39
Hemophilic arthropathy: a literature review. (6562449)
1983
40
Nonoperative management of hemophilic arthropathy and muscle hemorrhage. (6546071)
1983
41
Arthrographic pseudoloosening of Marmor total knee in hemophilic arthropathy: report of a case. (7285410)
1981
42
Traumatic aneurysm of the descending geniculate artery: a complication of suction drainage in synovectomy for hemophilic arthropathy. (7428228)
1980
43
Efficacy and safety of ibuprofen for hemophilic arthropathy. (7006539)
1980
44
A radiologic classification of hemophilic arthropathy. (7408294)
1980
45
Hemophilic arthropathy. Current concepts of pathogenesis and management. (849938)
1977
46
Cartilage in hemophilic arthropathy. Ultrastructural and microanalytical studies. (946396)
1976
47
Biochemical and physiological aspects of degenerative joint diseases with special reference to hemophilic arthropathy. (1053873)
1975
48
Hemophilic arthropathy. (4614656)
1974
49
The chaning prognosis in hemophilic arthropathy. (5366427)
1969
50
Hemophilic arthropathy in dogs. (13836046)
1959

Genetic Variations for Hemophilic Arthropathy

Expression for genes affiliated with Hemophilic Arthropathy

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hemophilic Arthropathy

Search GEO for disease gene expression data for Hemophilic Arthropathy.

Pathways for genes affiliated with Hemophilic Arthropathy

Sources:
12EMD Millipore, 38NCBI BioSystems Database, 54Reactome, 53R&D Systems, 52QIAGEN, 56SinoBiological, 30KEGG, 4Cell Signaling Technology
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Pathways related to Hemophilic Arthropathy according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
Hide members
9.5TNFSF11, TNFRSF11A
29.3TNFSF11, TNFRSF11B
3
Hide members
9.2F8, F9
4
Hide members
9.0TNFRSF11B, TNFSF11, TNFRSF11A
59.0TNFRSF11B, TNFSF11, TNFRSF11A
6
Hide members
9.0TNFRSF11B, TNFSF11, TNFRSF11A
79.0TNFRSF11A, TNFSF11, TNFRSF11B
8
Transcription Role of VDR in regulation of genes involved in osteoporosis
Hide members
9.0TNFRSF11A, TNFSF11, TNFRSF11B
9
Hide members
9.0TNFRSF11A, TNFSF11, TNFRSF11B
109.0PTGS2, TNFSF11, TNFRSF11A
119.0TNFRSF11A, TNFSF11, PTGS2
12
Hide members
8.9F8, F9, COMP
13
Hide members
8.4PTGS2, TNFRSF11B, TNFSF11, TNFRSF11A
14
Hide members
8.4TNFRSF11A, TNFSF11, TNFRSF11B, PTGS2

Compounds for genes affiliated with Hemophilic Arthropathy

Sources:
45Novoseek, 2BitterDB, 50PharmGKB, 11DrugBank, 24HMDB, 29IUPHAR, 60Tocris Bioscience
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Compounds related to Hemophilic Arthropathy according to GeneCards/GeneDecks:

(show top 50)    (show all 87)
idCompoundScoreTop Affiliating Genes
1glucose4510.4COMP
2acetaminophen45 2 50 11 2414.4F9
3pge24510.2PTGS2
4p003459.9HFE, COMP
5hcc-1459.7TNFSF11, TNFRSF11B
6estrogen459.7F8, F9
7tributylphosphate459.6F9, F8
8laccer459.6TNFSF11, TNFRSF11A
9rfviii459.6F8, F9
10teriparatide45 1110.6TNFSF11, TNFRSF11B
11kaolin459.6F9, F8
12tween 80459.6F9, F8
13ibandronate45 1110.5TNFRSF11B, TNFSF11
14deoxypyridinoline459.4TNFRSF11B, TNFSF11, COMP
15denosumab45 1110.4TNFRSF11A, TNFSF11, TNFRSF11B
16polyethylene459.4TNFRSF11A, TNFSF11, TNFRSF11B
17leflunomide50 45 1111.4COMP, TNFSF11, PTGS2
18infliximab45 50 1111.4TNFRSF11B, TNFSF11, COMP
19raloxifene45 29 50 1112.4TNFRSF11B, TNFSF11, TNFRSF11A
20procollagen459.3COMP, TNFSF11, TNFRSF11B
21hydroxyapatite459.3TNFRSF11B, TNFSF11, TNFRSF11A
22gp 130459.3TNFRSF11B, TNFSF11, TNFRSF11A
23risedronate45 60 50 29 1113.2PTGS2, TNFRSF11B, TNFSF11
24clodronate45 50 1111.2PTGS2, TNFRSF11B, TNFSF11
25lenalidomide45 1110.2PTGS2, TNFSF11
26ns 39845 6010.2PTGS2, TNFRSF11B, TNFSF11
27celecoxib45 60 29 50 11 2414.2TNFSF11, TNFRSF11B, PTGS2
281,25 dihydroxy vitamin d3459.2TNFRSF11A, TNFSF11, TNFRSF11B
29desmopressin45 60 29 1112.1PTGS2, F8, F9
30urea45 11 2411.0F9, TNFSF11, TNFRSF11B
31iron45 2410.0F8, HFE, PTGS2
32etanercept45 50 1110.9PTGS2, TNFRSF11B, TNFSF11, COMP
33latex458.9F8, TNFSF11, F9
34homocysteine45 249.9F9, TNFRSF11B, F8
35prostaglandin458.9TNFRSF11A, TNFSF11, TNFRSF11B, PTGS2
36thromboxane a245 249.9PTGS2, F8, TNFSF11
37prednisolone45 29 1110.8COMP, F9, TNFRSF11B, F8
38tgf beta1458.8F8, TNFRSF11B, COMP
39gold458.7TNFRSF11B, F8, HFE
40cyclosporin a45 29 6010.4F9, TNFSF11, TNFRSF11B, F8
41aspartate458.3COMP, F9, TNFRSF11B, F8, HFE
42heparin45 29 11 2411.2F9, TNFSF11, TNFRSF11B, F8
43creatinine458.2COMP, F9, TNFSF11, TNFRSF11B, F8
44dexamethasone45 50 29 1111.0F9, TNFSF11, TNFRSF11B, F8, PTGS2
45vegf458.0TNFRSF11A, TNFSF11, TNFRSF11B, F8, PTGS2
46nitric oxide45 11 2410.0TNFRSF11A, TNFSF11, TNFRSF11B, F8, PTGS2
47cysteine457.7COMP, F9, TNFSF11, TNFRSF11B, F8, HFE
48tyrosine457.6HFE, F8, TNFRSF11B, TNFSF11, TNFRSF11A, F9
49lipid457.4HFE, F8, TNFRSF11B, TNFSF11, TNFRSF11A, F9
50calcium45 50 11 2410.1COMP, F9, TNFRSF11A, TNFSF11, TNFRSF11B, F8

GO Terms for genes affiliated with Hemophilic Arthropathy

Sources:
16Gene Ontology
See all sources

Cellular components related to Hemophilic Arthropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.2F8, TNFRSF11B, TNFSF11, COMP
2extracellular regionGO:0055767.5F8, TNFRSF11B, TNFSF11, F9, COMP

Biological processes related to Hemophilic Arthropathy according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of fever generation by positive regulation of prostaglandin secretionGO:0718129.7TNFSF11, TNFRSF11A
2TNFSF11-mediated signaling pathwayGO:0718479.7TNFSF11, TNFRSF11A
3positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signalingGO:0718489.6TNFSF11, TNFRSF11A
4mammary gland alveolus developmentGO:0607499.6TNFSF11, TNFRSF11A
5monocyte chemotaxisGO:0025489.5TNFRSF11A, TNFSF11
6tumor necrosis factor-mediated signaling pathwayGO:0332099.5TNFSF11, TNFRSF11A
7osteoclast differentiationGO:0303169.4TNFSF11, TNFRSF11A
8response to tumor necrosis factorGO:0346129.3PTGS2, TNFRSF11A
9blood coagulation, intrinsic pathwayGO:0075979.2F8, F9

Products for genes affiliated with Hemophilic Arthropathy

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  • Proteins
  • Lysates
  • Antibodies

Sources for Hemophilic Arthropathy

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet