MCID: HMP018
MIFTS: 37

Hemophilic Arthropathy

Categories: Rare diseases

Aliases & Classifications for Hemophilic Arthropathy

MalaCards integrated aliases for Hemophilic Arthropathy:

Name: Hemophilic Arthropathy 49 69

Classifications:



External Ids:

UMLS 69 C0263725

Summaries for Hemophilic Arthropathy

MalaCards based summary : Hemophilic Arthropathy is related to arthropathy and osteoarthritis. An important gene associated with Hemophilic Arthropathy is HFE (Hemochromatosis), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Development Endothelin-1/EDNRA signaling. The drugs Hyaluronic acid and Triamcinolone have been mentioned in the context of this disorder. Affiliated tissues include bone, and related phenotypes are growth/size/body region and behavior/neurological

Related Diseases for Hemophilic Arthropathy

Diseases related to Hemophilic Arthropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Related Disease Score Top Affiliating Genes
1 arthropathy 30.4 COMP HFE TNFRSF11B TNFSF11
2 osteoarthritis 28.9 COMP PTGS2 TNFRSF11B TNFSF11
3 osteoporosis 28.9 TNFRSF11A TNFRSF11B TNFSF11
4 arthritis 28.9 PTGS2 TNFRSF11A TNFSF11
5 hemophilia 10.2
6 chondrocalcinosis 10.1 HFE TNFRSF11B
7 osteoarthritis with mild chondrodysplasia 10.0
8 bone mineral density quantitative trait locus 8 10.0
9 bone mineral density quantitative trait locus 15 10.0
10 aneurysm 10.0
11 periostitis 10.0 TNFRSF11A TNFRSF11B
12 shoulder impingement syndrome 10.0 PTGS2 TNFRSF11A
13 blood group, i system 9.9
14 factor viii deficiency 9.9
15 osteoid osteoma 9.9
16 hemophilia a 9.9
17 episodic pain syndrome, familial, 1 9.9
18 leukemia 9.9
19 von willebrand's disease 9.9
20 poliomyelitis 9.9
21 hemarthrosis 9.9
22 septic arthritis 9.9
23 rheumatic disease 9.9 PTGS2 TNFRSF11B
24 multicentric reticulohistiocytosis 9.9 TNFRSF11B TNFSF11
25 kummell's disease 9.8 TNFRSF11B TNFSF11
26 periodontitis, chronic 9.8 TNFRSF11B TNFSF11
27 chronic apical periodontitis 9.8 TNFRSF11B TNFSF11
28 chondroblastoma 9.8 PTGS2 TNFSF11
29 glucocorticoid-induced osteoporosis 9.8 TNFRSF11B TNFSF11
30 keratocystic odontogenic tumor 9.8 PTGS2 TNFSF11
31 breast leiomyosarcoma 9.8 TNFRSF11A TNFSF11
32 endosteal hyperostosis, autosomal dominant 9.8 TNFRSF11B TNFSF11
33 osteonecrosis 9.8 TNFRSF11B TNFSF11
34 aneurysmal bone cysts 9.8 TNFRSF11A TNFSF11
35 spondyloarthropathy 1 9.7 TNFRSF11B TNFSF11
36 cholesteatoma 9.7 TNFRSF11B TNFSF11
37 bone cancer 9.6 TNFRSF11A TNFSF11
38 aortic valve disease 2 9.6 TNFRSF11B TNFSF11
39 periodontitis 9.6 TNFRSF11B TNFSF11
40 synovitis 9.5 COMP TNFRSF11B TNFSF11
41 psoriatic arthritis 9.5 COMP TNFRSF11B TNFSF11
42 polyarticular onset juvenile idiopathic arthritis 9.4 TNFRSF11A TNFRSF11B TNFSF11
43 paget disease of bone 5, juvenile-onset 9.4 TNFRSF11A TNFRSF11B TNFSF11
44 familial expansile osteolysis 9.4 TNFRSF11A TNFRSF11B TNFSF11
45 cohen-gibson syndrome 9.4 TNFRSF11A TNFRSF11B TNFSF11
46 osteopetrosis 9.4 TNFRSF11A TNFSF11
47 multicentric carpotarsal osteolysis syndrome 9.4 TNFRSF11A TNFRSF11B TNFSF11
48 periapical periodontitis 9.4 TNFRSF11A TNFRSF11B TNFSF11
49 tooth resorption 9.4 TNFRSF11A TNFRSF11B TNFSF11
50 ischemic bone disease 9.4 TNFRSF11A TNFRSF11B TNFSF11

Graphical network of the top 20 diseases related to Hemophilic Arthropathy:



Diseases related to Hemophilic Arthropathy

Symptoms & Phenotypes for Hemophilic Arthropathy

MGI Mouse Phenotypes related to Hemophilic Arthropathy:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.85 HFE PTGS2 TNFRSF11A TNFRSF11B COMP TNFSF11
2 behavior/neurological MP:0005386 9.8 TNFSF11 HFE PTGS2 TNFRSF11A COMP
3 immune system MP:0005387 9.73 HFE PTGS2 TNFRSF11A TNFRSF11B COMP TNFSF11
4 hematopoietic system MP:0005397 9.72 TNFSF11 HFE PTGS2 TNFRSF11A TNFRSF11B
5 limbs/digits/tail MP:0005371 9.55 TNFRSF11A TNFRSF11B COMP TNFSF11 HFE
6 no phenotypic analysis MP:0003012 9.26 HFE PTGS2 TNFRSF11A TNFSF11
7 skeleton MP:0005390 9.02 PTGS2 TNFRSF11A TNFRSF11B COMP TNFSF11

Drugs & Therapeutics for Hemophilic Arthropathy

Drugs for Hemophilic Arthropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741 24759
2
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
3
Ropivacaine Approved Phase 4 84057-95-4 175805 71273
4 triamcinolone acetonide Phase 4
5 Adjuvants, Immunologic Phase 4
6 Triamcinolone diacetate Phase 4
7 Triamcinolone hexacetonide Phase 4
8 Viscosupplements Phase 4
9 Hylan Phase 4
10 Factor VIII Phase 4
11 Protective Agents Phase 4
12
Thrombin Approved, Investigational
13 Coagulants
14 Hemostatics
15 Soy Bean Nutraceutical

Interventional clinical trials:

(show all 19)

# Name Status NCT ID Phase Drugs
1 Viscosupplementation in Patients With Hemophilic Arthropathy Completed NCT01748201 Phase 4
2 Validation of Ultrasound as a Diagnostic Tool for Assessment of Hemophilic Arthropathy of Knees and Ankles Completed NCT01232634 Phase 2
3 A Proof-of-Concept Study of AC-201 Controlled-Release Tablet (CR Tablet) in Patients With Hemophilic Arthropathy Recruiting NCT02994147 Phase 2 Placebo;AC-201CR
4 Myofascial Therapy in Patients With Hemophilic Arthropathy Unknown status NCT02433782
5 Assessment of Proprioceptive and Functional Characteristics in Patients With Hemophilia Unknown status NCT02165592
6 Effectiveness of the Myofascial Therapy in the Hemophilic Arthropathy of Ankle Completed NCT02825667
7 Platelet-Rich Plasma Intra-Articular Injection in Treating Hemophilic Arthropathy Completed NCT02601170 Hyaluronic Acid Viscosupplementation
8 Bilateral Deficit Phenomenon in Patients With Haemophilic Arthropathy Completed NCT02165462
9 Physiotherapy in the Haemophilic Arthropathy of the Elbow. Completed NCT02198040
10 Manual Therapy in Haemophilic Arthropathy of the Knee Completed NCT02198014
11 Gait Evaluation in Haemophiliac Patients Completed NCT00824798
12 Exploratory Pilot Study of Physical Activity Monitoring in Adult Patients With Haemophilia A by Means of Accelerometry Completed NCT02253693
13 Educational Physiotherapy in Haemophilia Completed NCT02825706
14 Efficacy and Safety of Shea Nut Oil in Hemophilic Arthropathy Recruiting NCT02569359
15 Fascial Therapy in Elbow Hemophilic Arthropathy Recruiting NCT03009591
16 TGA (Thrombin Generation Assay) and Prophylaxis in Haemophilia Recruiting NCT02781766
17 Personalized Prophylactic Treatment With Advate® in Severe or Moderate Haemophilia A Patients Recruiting NCT02622646 Recombinant VIII factor
18 Joint Outcome Study Continuation for Children With Severe Factor VIII Deficiency Enrolling by invitation NCT01000844
19 Osteoporosis and MRI Study in Hemophilia Terminated NCT01460147

Search NIH Clinical Center for Hemophilic Arthropathy

Genetic Tests for Hemophilic Arthropathy

Anatomical Context for Hemophilic Arthropathy

MalaCards organs/tissues related to Hemophilic Arthropathy:

38
Bone

Publications for Hemophilic Arthropathy

Articles related to Hemophilic Arthropathy:

(show top 50) (show all 154)
# Title Authors Year
1
Missing angiogenic factors in hemophilic arthropathy. ( 29103337 )
2018
2
Response to: missing angiogenic factors in hemophilic arthropathy. ( 29092644 )
2018
3
Safety and effectiveness of fascial therapy in adult patients with hemophilic arthropathy. A pilot study. ( 29334292 )
2018
4
Advanced Hemophilic Arthropathy: Sensitivity of Soft Tissue Discrimination With Musculoskeletal Ultrasound. ( 29363781 )
2018
5
Synovectomy using Samarium-153 Hydroxyapatite in the Elbows and Ankles of Patients with Hemophilic Arthropathy. ( 29398959 )
2018
6
Simultaneous bilateral total knee arthroplasty in patients with end-stage hemophilic arthropathy: a mean follow-up of 6 years. ( 29371670 )
2018
7
Management of Hemophilic Arthropathy of the Ankle. ( 28891453 )
2017
8
Pathophysiology of Hemophilic Arthropathy. ( 28672826 )
2017
9
Hemophilic Arthropathy. ( 28662249 )
2017
10
A Combined Ultrasonographic and Conventional Radiographic Assessment of Hemophilic Arthropathy. ( 28824241 )
2017
11
Ultrasound for Early Detection of Joint Disease in Patients with Hemophilic Arthropathy. ( 28758960 )
2017
12
Pathophysiology of hemophilic arthropathy and potential targets for therapy. ( 27890816 )
2017
13
Cytokines in the pathogenesis of hemophilic arthropathy. ( 29153709 )
2017
14
Radiosynoviorthesis in hemophilic arthropathy: pathologic blood pool imaging on pre-therapeutic bone scintigraphy is not a predictor of treatment success. ( 27796541 )
2016
15
Assessment of Hemophilic Arthropathy by Ultrasound: Where Do We Stand? ( 27124619 )
2016
16
Altered collagen turnover in factor VIII-deficient rats with hemophilic arthropathy identifies potential novel serological biomarkers in hemophilia. ( 27681457 )
2016
17
Synovium and cartilage biomarkers in hemophilic arthropathy. ( 26761216 )
2016
18
Soluble vascular cell adhesion molecular-1 is a potential biological indicator of hemophilic arthropathy. ( 27861372 )
2016
19
Advances and challenges in hemophilic arthropathy. ( 26805902 )
2016
20
Intra-articular injections of mesenchymal stem cells (MSCs) as a treatment for hemophilic arthropathy. ( 27322636 )
2016
21
The F8(-/-) rat as a model of hemophilic arthropathy. ( 27060449 )
2016
22
Subjective results of joint lavage and viscosupplementation in hemophilic arthropathy. ( 26207096 )
2015
23
Hemophilic arthropathy of the elbow: prophylaxis, imaging, and the role of invasiveA management. ( 26385390 )
2015
24
Total Knee Arthroplasty in Hemophilic Arthropathy. ( 26665252 )
2015
25
Inflammation is key to hemophilic arthropathy. ( 26542253 )
2015
26
The long-term effects of radioactive phosphorous synoviorthesis on hemophilic arthropathy. ( 25976470 )
2015
27
Patient dissatisfaction after total knee arthroplasty for hemophilic arthropathy and osteoarthritis (non-hemophilia patients). ( 26561009 )
2015
28
Total ankle replacement or ankle fusion in painful advanced hemophilic arthropathy of the ankle. ( 26358145 )
2015
29
Vascular remodeling underlies rebleeding in hemophilic arthropathy. ( 26257191 )
2015
30
Diagnostic accuracy of ultrasound for assessment of hemophilic arthropathy: MRI correlation. ( 25714320 )
2015
31
Manual therapy in the treatment of ankle hemophilic arthropathy. A randomized pilot study. ( 24678758 )
2014
32
The Effectiveness of Tools for Monitoring Hemophilic Arthropathy. ( 25000469 )
2014
33
Osteoid osteoma of the elbow mimicking hemophilic arthropathy. ( 24749122 )
2014
34
Optimal management of hemophilic arthropathy and hematomas. ( 25378964 )
2014
35
Hemophilic arthropathy: a review of imaging and staging. ( 24332203 )
2013
36
Outcome of Total Knee Arthroplasty in Hemophilic Arthropathy. ( 23958233 )
2013
37
Viscosupplementation in patients with hemophilic arthropathy. ( 24453636 )
2013
38
Hemophilic arthropathy of shoulder joints: clinical, radiographic, and ultrasonographic characteristics of seventy patients. ( 23553306 )
2013
39
Arthroscopic ankle arthrodesis in hemophilic arthropathy. ( 23478887 )
2013
40
Outcome of total knee arthroplasty combined patelloplasty for end-stage type A hemophilic arthropathy. ( 21342764 )
2012
41
Osteoporosis/osteopenia and hemophilic arthropathy in severe hemophilic patients. ( 22292576 )
2012
42
Total knee arthroplasty in a patient with hemophilic arthropathy and high-titer inhibitors: a cost analysis. ( 22153945 )
2012
43
Intra-articular injection of mesenchymal stem cells expressing coagulation factor ameliorates hemophilic arthropathy in factorA VIII-deficient mice. ( 22784361 )
2012
44
Impact of ankle osteoarthritis on the energetics and mechanics of gait: the case of hemophilic arthropathy. ( 22381586 )
2012
45
Hemophilic arthropathy in patients with von Willebrand disease. ( 23010260 )
2012
46
RANK-RANKL-OPG in hemophilic arthropathy: from clinical and imaging diagnosis to histopathology. ( 22753650 )
2012
47
Synoviorthesis induced by rifampicin in hemophilic arthropathy: a report of 24 treated joints. ( 21318571 )
2011
48
Shoulder arthroplasty in hemophilic arthropathy. ( 21167746 )
2011
49
Unraveling hemophilic arthropathy. ( 21350060 )
2011
50
Hemophilic arthropathy of the elbow. ( 21501786 )
2011

Variations for Hemophilic Arthropathy

Expression for Hemophilic Arthropathy

Search GEO for disease gene expression data for Hemophilic Arthropathy.

Pathways for Hemophilic Arthropathy

Pathways related to Hemophilic Arthropathy according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.89 PTGS2 TNFRSF11A TNFRSF11B TNFSF11
2
Show member pathways
12.22 TNFRSF11A TNFRSF11B TNFSF11
3
Show member pathways
12.2 TNFRSF11A TNFRSF11B TNFSF11
4 12.12 PTGS2 TNFRSF11A TNFSF11
5 11.65 TNFRSF11A TNFRSF11B TNFSF11
6
Show member pathways
11.65 PTGS2 TNFRSF11A TNFRSF11B TNFSF11
7 11.48 TNFRSF11A TNFSF11
8 11.48 PTGS2 TNFRSF11A TNFSF11
9
Show member pathways
11.37 TNFRSF11A TNFSF11
10
Show member pathways
11.35 TNFRSF11A TNFRSF11B TNFSF11
11 10.99 TNFRSF11A TNFRSF11B TNFSF11
12 10.55 TNFRSF11B TNFSF11
13 10 TNFRSF11A TNFRSF11B TNFSF11

GO Terms for Hemophilic Arthropathy

Cellular components related to Hemophilic Arthropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 8.92 HFE TNFRSF11A TNFRSF11B TNFSF11

Biological processes related to Hemophilic Arthropathy according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.67 PTGS2 TNFRSF11A TNFRSF11B
2 positive regulation of DNA binding transcription factor activity GO:0051091 9.55 TNFRSF11A TNFSF11
3 ossification GO:0001503 9.54 TNFRSF11A TNFSF11
4 response to lipopolysaccharide GO:0032496 9.54 PTGS2 TNFRSF11A TNFRSF11B
5 apoptotic signaling pathway GO:0097190 9.52 TNFRSF11A TNFRSF11B
6 response to cytokine GO:0034097 9.51 PTGS2 TNFRSF11A
7 monocyte chemotaxis GO:0002548 9.48 TNFRSF11A TNFSF11
8 response to radiation GO:0009314 9.46 PTGS2 TNFRSF11A
9 response to tumor necrosis factor GO:0034612 9.43 PTGS2 TNFRSF11A
10 tumor necrosis factor-mediated signaling pathway GO:0033209 9.43 TNFRSF11A TNFRSF11B TNFSF11
11 osteoclast differentiation GO:0030316 9.4 TNFRSF11A TNFSF11
12 mammary gland alveolus development GO:0060749 9.32 TNFRSF11A TNFSF11
13 TNFSF11-mediated signaling pathway GO:0071847 9.16 TNFRSF11A TNFSF11
14 positive regulation of fever generation by positive regulation of prostaglandin secretion GO:0071812 8.96 TNFRSF11A TNFSF11
15 positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling GO:0071848 8.62 TNFRSF11A TNFSF11

Molecular functions related to Hemophilic Arthropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor-activated receptor activity GO:0005031 8.62 TNFRSF11A TNFRSF11B

Sources for Hemophilic Arthropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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