MCID: HMP018
MIFTS: 34

Hemophilic Arthropathy malady

Rare diseases category

Summaries for Hemophilic Arthropathy

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MalaCards based summary: Hemophilic Arthropathy is related to arthropathy and osteoporosis. An important gene associated with Hemophilic Arthropathy is COMP (cartilage oligomeric matrix protein), and among its related pathways are Rheumatoid arthritis and Apoptosis and survival Anti apoptotic TNFs NF kB Bcl 2 pathway. The compounds hcc-1 and tributylphosphate have been mentioned in the context of this disorder. Affiliated tissues include bone, and related mouse phenotypes are liver/biliary system and limbs/digits/tail.

Aliases & Classifications for Hemophilic Arthropathy

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Hemophilic Arthropathy, Aliases & Descriptions:

Name: Hemophilic Arthropathy 41 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Related Diseases for Hemophilic Arthropathy

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Diseases related to Hemophilic Arthropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 80)
idRelated DiseaseScoreTop Affiliating Genes
1arthropathy30.8TNFRSF11B, COMP, F8, TNFSF11, F9, HFE
2osteoporosis30.5TNFSF11, TNFRSF11B, TNFRSF11A
3hemarthrosis30.5F8, F9
4hemophilia a30.5F9, F8
5osteoarthritis29.5COMP, TNFRSF11A, TNFSF11, TNFRSF11B, PTGS2, HFE
6arthritis29.5HFE, PTGS2, TNFRSF11B, TNFSF11, TNFRSF11A, COMP
7paget disease of bone10.5TNFRSF11A
8factor xii deficiency10.5F9
9osteomyelitis10.4TNFSF11
10hemophilia10.4
11aneurysm10.4
12periapical granuloma10.4TNFSF11
13factor v deficiency10.3F8
14cardiac tamponade10.3F8
15leukemia10.2
16septic arthritis10.2
17poliomyelitis10.2
18hyperostosis, endosteal10.2TNFSF11, TNFRSF11B
19pain agnosia10.1PTGS2, F9
20aortic valve disease 210.1TNFSF11, TNFRSF11B
21gingivitis10.1TNFRSF11B, TNFSF11
22factor xi deficiency, autosomal recessive10.1F9, F8
23factor viii deficiency10.1F9, F8
24ameloblastoma10.1TNFSF11, TNFRSF11B
25hemorrhagic disease10.1F8, F9
26factor vii deficiency10.1F9, F8
27von willebrand's disease10.1F9, F8
28cholesteatoma10.1TNFRSF11B, TNFSF11
29spondyloarthropathy 110.1TNFSF11, TNFRSF11B
30bernard-soulier syndrome, type c10.1F9, F8
31thrombophilia due to activated protein c resistance10.1F9, F8
32hemophilia b10.1F9, F8
33factor v leiden thrombophilia10.1F8, F9
34glanzmann thrombasthenia10.1F8, F9
35hyperparathyroidism10.1TNFSF11, TNFRSF11B
36thrombophilia10.0F9, F8
37disseminated intravascular coagulation10.0F8, F9
38periodontitis10.0TNFRSF11B, TNFSF11
39liver cirrhosis10.0F9, HFE, TNFRSF11B
40psoriatic arthritis10.0TNFRSF11B, TNFSF11, COMP
41synovitis10.0TNFRSF11B, COMP, TNFSF11
42paget disease, juvenile10.0TNFSF11, TNFRSF11B, TNFRSF11A
43osteolysis, familial expansile10.0TNFRSF11A, TNFSF11, TNFRSF11B
44marchiafava bignami disease10.0TNFRSF11B, TNFRSF11A, TNFSF11
45thrombophilia due to thrombin defect10.0F8, F9
46giant cell tumor10.0TNFRSF11A, TNFRSF11B, TNFSF11
47osteopetrosis10.0TNFRSF11B, TNFRSF11A, TNFSF11
48bone cancer10.0TNFRSF11B, TNFSF11, TNFRSF11A
49hypercalcemia10.0TNFRSF11B, TNFRSF11A, TNFSF11
50secondary syphilis10.0TNFRSF11B, TNFSF11, TNFRSF11A

Graphical network of the top 20 diseases related to Hemophilic Arthropathy:



Diseases related to hemophilic arthropathy

Symptoms for Hemophilic Arthropathy

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Drugs & Therapeutics for Hemophilic Arthropathy

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Drug clinical trials:

Search ClinicalTrials for Hemophilic Arthropathy

Search NIH Clinical Center for Hemophilic Arthropathy

Genetic Tests for Hemophilic Arthropathy

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Anatomical Context for Hemophilic Arthropathy

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MalaCards organs/tissues related to Hemophilic Arthropathy:

31
Bone

Animal Models for Hemophilic Arthropathy or affiliated genes

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Publications for Hemophilic Arthropathy

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Articles related to Hemophilic Arthropathy:

(show top 50)    (show all 123)
idTitleAuthorsYear
1
Optimal management of hemophilic arthropathy and hematomas. (25378964)
2014
2
Manual therapy in the treatment of ankle hemophilic arthropathy. A randomized pilot study. (24678758)
2014
3
Viscosupplementation in patients with hemophilic arthropathy. (24453636)
2013
4
Hemophilic arthropathy of shoulder joints: clinical, radiographic, and ultrasonographic characteristics of seventy patients. (23553306)
2013
5
RANK-RANKL-OPG in hemophilic arthropathy: from clinical and imaging diagnosis to histopathology. (22753650)
2012
6
Impact of ankle osteoarthritis on the energetics and mechanics of gait: the case of hemophilic arthropathy. (22381586)
2012
7
Hemophilic arthropathy in patients with von Willebrand disease. (23010260)
2012
8
A long term results of external beam radiation therapy in hemophilic arthropathy of the ankle in children. (21165288)
2010
9
Severe hemophilic arthropathy of the elbow and knee. (17552061)
2007
10
Functional disability in children with hemophilic arthropathy. (16485109)
2006
11
HFE mutations in the pathobiology of hemophilic arthropathy. (15802547)
2005
12
Hemophilic arthropathy of the elbow treated by total elbow replacement. A case series. (14996887)
2004
13
Initiation of degenerative joint damage by experimental bleeding combined with loading of the joint: a possible mechanism of hemophilic arthropathy. (15188380)
2004
14
Total knee arthroplasty in hemophilic arthropathy. (14716652)
2004
15
Periarticular aneurysm following total knee replacement in hemophilic arthropathy. A case report. (14668517)
2003
16
Total knee arthroplasty in hemophilic arthropathy. (12639614)
2003
17
Current treatment of hemophilic arthropathy. (11880733)
2002
18
Hemophilic arthropathy: evaluation of clinical and radiological characteristics and disability. (11105618)
2000
19
Hemophilic arthropathy of the elbow. (8543615)
1995
20
Synoviorthesis with colloidal 32P chromic phosphate for the treatment of hemophilic arthropathy. (8150815)
1994
21
Synovectomy of the ankle for hemophilic arthropathy. (8200887)
1994
22
Utility of magnetic resonance imaging for management of hemophilic arthropathy in children. (8355113)
1993
23
Ultrasound in the diagnosis of the early stages of hemophilic arthropathy of the knee. (1632211)
1992
24
MR imaging in hemophilic arthropathy. (1777491)
1991
25
Radiocolloids in the management of hemophilic arthropathy in children and adolescents. (1997228)
1991
26
Surgical management of advanced hemophilic arthropathy. (2408056)
1990
27
Surgical management of advanced hemophilic arthropathy. An overview of 20 years' experience. (2650951)
1989
28
Roentgenographic classifications of hemophilic arthropathy. Comparison of three systems and correlation with clinical parameters. (2918008)
1989
29
Total knee arthroplasty for the treatment of chronic hemophilic arthropathy. (2805504)
1989
30
Intraarticular methylprednisolone therapy in hemophilic arthropathy. (3354555)
1988
31
Hemophilic arthropathy of the temporomandibular joint: review of the literature, a case report, and discussion. (3278263)
1988
32
Synovectomy of the knee for hemophilic arthropathy. (3805065)
1987
33
Hemophilic arthropathy of the upper limb. (3568484)
1987
34
Hemophilic arthropathy resulting in a locked shoulder. (3955945)
1986
35
Total knee arthroplasty in chronic hemophilic arthropathy. (3714579)
1986
36
Synovectomy in hemophilic arthropathy. A retrospective review of 17 cases. (3955942)
1986
37
A long-term study of hemophilic arthropathy of the knee joint on a program of Factor VIII replacement given at time of each hemarthrosis. (3917602)
1985
38
Hemophilic arthropathy complicated by polyarticular septic arthritis. (6421050)
1984
39
Hemophilic arthropathy: a literature review. (6562449)
1983
40
Nonsteroidal anti-inflammatory drugs in the treatment of hemophilic arthropathy. (7072708)
1982
41
Traumatic aneurysm of the descending geniculate artery: a complication of suction drainage in synovectomy for hemophilic arthropathy. (7428228)
1980
42
Hemophilic arthropathy in the elbow. (302402)
1977
43
Hemophilic arthropathy. Current concepts of pathogenesis and management. (849938)
1977
44
Cartilage in hemophilic arthropathy. Ultrastructural and microanalytical studies. (946396)
1976
45
Biochemical and physiological aspects of degenerative joint diseases with special reference to hemophilic arthropathy. (1053873)
1975
46
Hemophilic arthropathy. (4614656)
1974
47
Hemophilic arthropathy. (6048906)
1967
48
Hemophilic arthropathy. (13775889)
1960
49
Hemophilic arthropathy in dogs. (13836046)
1959
50
Hemophilic arthropathy. (13282597)
1956

Variations for Hemophilic Arthropathy

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Expression for genes affiliated with Hemophilic Arthropathy

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Search GEO for disease gene expression data for Hemophilic Arthropathy.

Pathways for genes affiliated with Hemophilic Arthropathy

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Pathways related to Hemophilic Arthropathy according to GeneCards Suite gene sharing:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5TNFSF11, TNFRSF11A
2
Show member pathways
Apoptosis and survival Anti apoptotic TNFs NF kB IAP pathway58
9.5TNFRSF11A, TNFSF11
39.3TNFSF11, TNFRSF11B
4
Show member pathways
9.2F8, F9
5
Show member pathways
Complement Activation, Classical Pathway36
Complement and Coagulation Cascades36
9.2F8, F9
6
Show member pathways
Apoptosis and survival TNFR1 signaling pathway58
TWEAK Signaling Pathway36
Apoptosis Modulation by HSP7036
HIV-1 Nef- Negative effector of Fas and TNF-alpha36
9.0TNFRSF11B, TNFSF11, TNFRSF11A
7
Show member pathways
9.0TNFRSF11A, TNFSF11, TNFRSF11B
89.0TNFRSF11A, TNFSF11, TNFRSF11B
99.0TNFRSF11B, TNFSF11, TNFRSF11A
109.0TNFRSF11B, TNFSF11, TNFRSF11A
11
Show member pathways
9.0TNFRSF11A, TNFSF11, TNFRSF11B
129.0PTGS2, TNFSF11, TNFRSF11A
139.0TNFRSF11A, TNFSF11, PTGS2
14
Show member pathways
RANKL/RANK Signaling Pathway36
Apoptosis and survival APRIL and BAFF signaling58
8.4PTGS2, TNFRSF11B, TNFSF11, TNFRSF11A
15
Show member pathways
8.4TNFRSF11A, TNFSF11, TNFRSF11B, PTGS2

Compounds for genes affiliated with Hemophilic Arthropathy

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Compounds related to Hemophilic Arthropathy according to GeneCards Suite gene sharing:

(show top 50)    (show all 102)
idCompoundScoreTop Affiliating Genes
1hcc-1439.7TNFSF11, TNFRSF11B
2tributylphosphate439.6F9, F8
3rfviii439.6F9, F8
4kaolin439.5F9, F8
5teriparatide43 1210.5TNFRSF11B, TNFSF11
6tween 80439.5F8, F9
7ibandronate43 1210.4TNFRSF11B, TNFSF11
8p003439.4COMP, HFE, TNFRSF11B
9deoxypyridinoline439.4COMP, TNFSF11, TNFRSF11B
10denosumab43 1210.4TNFSF11, TNFRSF11A, TNFRSF11B
11leflunomide43 49 1211.4PTGS2, TNFSF11, COMP
12polyethylene439.4TNFRSF11A, TNFSF11, TNFRSF11B
13infliximab43 49 1211.4COMP, TNFRSF11B, TNFSF11
14raloxifene43 49 28 1212.4TNFRSF11A, TNFSF11, TNFRSF11B
15procollagen439.3TNFRSF11B, COMP, TNFSF11
16hydroxyapatite439.3TNFRSF11A, TNFSF11, TNFRSF11B
17gp 130439.3TNFRSF11B, TNFSF11, TNFRSF11A
18risedronate43 49 28 59 1213.2TNFSF11, TNFRSF11B, PTGS2
19clodronate43 49 1211.2TNFRSF11B, TNFSF11, PTGS2
20ns 39843 5910.2TNFSF11, TNFRSF11B, PTGS2
211,25 dihydroxy vitamin d3439.2TNFRSF11B, TNFRSF11A, TNFSF11
22laccer439.2TNFRSF11A, TNFSF11
23celecoxib43 59 28 49 24 1214.2TNFRSF11B, TNFSF11, PTGS2
24desmopressin43 59 28 1212.1F8, F9, PTGS2
25acetaminophen43 2 49 24 1213.1F9, PTGS2, F8
26urea43 24 1211.0TNFRSF11B, TNFSF11, F9
27homocysteine43 249.9F8, TNFRSF11B, F9
28etanercept43 49 1210.9TNFSF11, PTGS2, COMP, TNFRSF11B
29latex438.9F8, TNFSF11, F9
30prostaglandin438.9TNFRSF11A, TNFRSF11B, PTGS2, TNFSF11
31agarose438.9COMP, F8, HFE
32thromboxane a243 249.9TNFSF11, PTGS2, F8
33prednisolone43 28 1210.8COMP, F8, TNFRSF11B, F9
34pge2438.7TNFRSF11A, PTGS2, TNFSF11, TNFRSF11B
35tgf beta1438.7COMP, F8, TNFRSF11B
36gold438.7F8, HFE, TNFRSF11B
37iron43 249.5HFE, F8, PTGS2, TNFRSF11B
38cyclosporin a43 28 5910.4F9, TNFRSF11B, TNFSF11, F8
39aspartate438.3TNFRSF11B, F8, COMP, HFE, F9
40glucose438.3HFE, COMP, F9, F8, TNFRSF11B
41heparin43 28 24 1211.3TNFRSF11B, TNFSF11, F8, F9
42creatinine438.2COMP, F8, F9, TNFRSF11B, TNFSF11
43vegf438.0F8, TNFRSF11B, PTGS2, TNFRSF11A, TNFSF11
44nitric oxide43 24 1210.0F8, PTGS2, TNFRSF11A, TNFSF11, TNFRSF11B
45cysteine437.7HFE, F9, TNFSF11, TNFRSF11B, F8, COMP
46calcium43 49 24 1210.7COMP, F8, TNFRSF11B, TNFSF11, F9, TNFRSF11A
47tyrosine437.7F9, F8, HFE, TNFSF11, TNFRSF11B, TNFRSF11A
48dexamethasone43 49 28 1210.6F8, TNFSF11, PTGS2, TNFRSF11B, TNFRSF11A, F9
49lipid437.4HFE, COMP, TNFRSF11B, TNFSF11, TNFRSF11A, F9
50estrogen437.2F8, PTGS2, TNFRSF11B, TNFSF11, TNFRSF11A, F9

GO Terms for genes affiliated with Hemophilic Arthropathy

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Cellular components related to Hemophilic Arthropathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.2COMP, F8, TNFRSF11B, TNFSF11
2extracellular regionGO:00055767.5COMP, F8, TNFRSF11B, TNFSF11, F9

Biological processes related to Hemophilic Arthropathy according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of fever generation by positive regulation of prostaglandin secretionGO:00718129.7TNFSF11, TNFRSF11A
2positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signalingGO:00718489.7TNFRSF11A, TNFSF11
3TNFSF11-mediated signaling pathwayGO:00718479.7TNFRSF11A, TNFSF11
4mammary gland alveolus developmentGO:00607499.6TNFSF11, TNFRSF11A
5monocyte chemotaxisGO:00025489.6TNFSF11, TNFRSF11A
6osteoclast differentiationGO:00303169.5TNFSF11, TNFRSF11A
7ossificationGO:00015039.5TNFSF11, TNFRSF11A
8response to tumor necrosis factorGO:00346129.5PTGS2, TNFRSF11A
9blood coagulation, intrinsic pathwayGO:00075979.3F9, F8
10tumor necrosis factor-mediated signaling pathwayGO:00332099.2TNFSF11, TNFRSF11A

Products for genes affiliated with Hemophilic Arthropathy

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Sources for Hemophilic Arthropathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet