MCID: HMP018
MIFTS: 40

Hemophilic Arthropathy malady

Rare diseases category
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Summaries for Hemophilic Arthropathy

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65Wikipedia, 33MalaCards
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Wikipedia:65 Haemophilia (/hi?m??f?li?/; also spelled hemophilia in North America, from the Greek haima ????... more...

MalaCards: Hemophilic Arthropathy is related to arthropathy and osteoporosis. An important gene associated with Hemophilic Arthropathy is COMP (cartilage oligomeric matrix protein), and among its related pathways are Rheumatoid arthritis and Apoptosis and survival Anti apoptotic TNFs NF kB Bcl 2 pathway. The compounds hcc-1 and tributylphosphate have been mentioned in the context of this disorder. Affiliated tissues include bone, and related mouse phenotypes are liver/biliary system and limbs/digits/tail.

Aliases & Classifications for Hemophilic Arthropathy

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43NIH Rare Diseases, 62UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Aliases & Descriptions:

hemophilic arthropathy 43 62


Related Diseases for Hemophilic Arthropathy

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17GeneCards, 18GeneDecks
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Diseases related to Hemophilic Arthropathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 78)
idRelated DiseaseScoreTop Affiliating Genes
1arthropathy31.6TNFRSF11B, COMP, F8, TNFSF11, F9, HFE
2osteoporosis30.5TNFSF11, TNFRSF11B, TNFRSF11A
3hemarthrosis30.3F8, F9
4osteoarthritis30.1COMP, TNFRSF11A, TNFSF11, TNFRSF11B, PTGS2, HFE
5arthritis30.1HFE, PTGS2, TNFRSF11B, TNFSF11, TNFRSF11A, COMP
6hemophilia10.4
7aneurysm10.4
8septic arthritis10.2
9leukemia10.2
10poliomyelitis10.2
11paget's disease of bone10.1TNFRSF11A
12factor xii deficiency10.1F9
13osteomyelitis10.1TNFSF11
14periapical granuloma10.1TNFSF11
15factor v deficiency10.1F8
16cardiac tamponade10.1F8
17pain agnosia10.0PTGS2, F9
18osteosclerosis10.0TNFSF11, TNFRSF11B
19aortic valve stenosis10.0TNFSF11, TNFRSF11B
20gingivitis10.0TNFRSF11B, TNFSF11
21factor xi deficiency10.0F9, F8
22adenoameloblastoma10.0TNFSF11, TNFRSF11B
23hemorrhagic disease10.0F8, F9
24factor vii deficiency10.0F9, F8
25von willebrand's disease10.0F9, F8
26factor viii deficiency10.0F9, F8
27cholesteatoma10.0TNFRSF11B, TNFSF11
28ankylosing spondylitis10.0TNFSF11, TNFRSF11B
29bernard-soulier syndrome10.0F9, F8
30hemophilia b10.0F9, F8
31glanzmann's thrombasthenia10.0F8, F9
32hyperparathyroidism10.0TNFSF11, TNFRSF11B
33thrombophilia10.0F9, F8
34disseminated intravascular coagulation10.0F8, F9
35periodontitis10.0TNFRSF11B, TNFSF11
36thromboembolism10.0F8, F9
37liver cirrhosis10.0F9, HFE, TNFRSF11B
38psoriatic arthritis10.0TNFRSF11B, TNFSF11, COMP
39synovitis10.0TNFRSF11B, COMP, TNFSF11
40paget disease, juvenile10.0TNFSF11, TNFRSF11B, TNFRSF11A
41polyostotic osteolytic dysplasia, hereditary expansile10.0TNFRSF11A, TNFSF11, TNFRSF11B
42venous thrombosis10.0F8, F9
43giant cell tumor10.0TNFRSF11A, TNFRSF11B, TNFSF11
44osteoporosis, postmenopausal10.0TNFRSF11A, TNFRSF11B, TNFSF11
45osteopetrosis10.0TNFRSF11B, TNFRSF11A, TNFSF11
46bone carcinoma10.0TNFRSF11B, TNFSF11, TNFRSF11A
47hypercalcemia10.0TNFRSF11B, TNFRSF11A, TNFSF11
48secondary syphilis10.0TNFRSF11B, TNFSF11, TNFRSF11A
49periodontal disease10.0TNFRSF11B, TNFSF11, TNFRSF11A
50vascular disease10.0TNFRSF11A, TNFSF11, TNFRSF11B

Graphical network of the top 20 diseases related to Hemophilic Arthropathy:



Diseases related to hemophilic arthropathy

Symptoms for Hemophilic Arthropathy

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Drugs & Therapeutics for Hemophilic Arthropathy

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Hemophilic Arthropathy

Search NIH Clinical Center for Hemophilic Arthropathy

Genetic Tests for Hemophilic Arthropathy

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Anatomical Context for Hemophilic Arthropathy

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33MalaCards
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MalaCards organs/tissues related to Hemophilic Arthropathy:

33
Bone

Animal Models for Hemophilic Arthropathy or affiliated genes

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37MGI
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Publications for Hemophilic Arthropathy

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52PubMed
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Articles related to Hemophilic Arthropathy:

(show top 50)    (show all 117)
idTitleAuthorsYear
1
Hemophilic arthropathy of shoulder joints: clinical, radiographic, and ultrasonographic characteristics of seventy patients. (23553306)
2013
2
RANK-RANKL-OPG in hemophilic arthropathy: from clinical and imaging diagnosis to histopathology. (22753650)
2012
3
Impact of ankle osteoarthritis on the energetics and mechanics of gait: the case of hemophilic arthropathy. (22381586)
2012
4
Hemophilic arthropathy in patients with von Willebrand disease. (23010260)
2012
5
A long term results of external beam radiation therapy in hemophilic arthropathy of the ankle in children. (21165288)
2010
6
Hemophilic arthropathy. (21623422)
2010
7
Severe hemophilic arthropathy of the elbow and knee. (17552061)
2007
8
Functional disability in children with hemophilic arthropathy. (16485109)
2006
9
HFE mutations in the pathobiology of hemophilic arthropathy. (15802547)
2005
10
Total knee arthroplasty in hemophilic arthropathy of the knee. (16310005)
2005
11
Hemophilic arthropathy of the elbow treated by total elbow replacement. A case series. (14996887)
2004
12
Initiation of degenerative joint damage by experimental bleeding combined with loading of the joint: a possible mechanism of hemophilic arthropathy. (15188380)
2004
13
Total knee arthroplasty in hemophilic arthropathy. (14716652)
2004
14
Periarticular aneurysm following total knee replacement in hemophilic arthropathy. A case report. (14668517)
2003
15
Total knee arthroplasty in hemophilic arthropathy. (12639614)
2003
16
Current treatment of hemophilic arthropathy. (11880733)
2002
17
Hemophilic arthropathy: evaluation of clinical and radiological characteristics and disability. (11105618)
2000
18
Hemophilic arthropathy of the elbow. (8543615)
1995
19
Synoviorthesis with colloidal 32P chromic phosphate for the treatment of hemophilic arthropathy. (8150815)
1994
20
Synovectomy of the ankle for hemophilic arthropathy. (8200887)
1994
21
Utility of magnetic resonance imaging for management of hemophilic arthropathy in children. (8355113)
1993
22
Ultrasound in the diagnosis of the early stages of hemophilic arthropathy of the knee. (1632211)
1992
23
MR imaging in hemophilic arthropathy. (1777491)
1991
24
Radiocolloids in the management of hemophilic arthropathy in children and adolescents. (1997228)
1991
25
Surgical management of advanced hemophilic arthropathy. (2408056)
1990
26
Surgical management of advanced hemophilic arthropathy. An overview of 20 years' experience. (2650951)
1989
27
Roentgenographic classifications of hemophilic arthropathy. Comparison of three systems and correlation with clinical parameters. (2918008)
1989
28
Total knee arthroplasty for the treatment of chronic hemophilic arthropathy. (2805504)
1989
29
Nonsurgical management of hemophilic arthropathy. (2649587)
1989
30
Intraarticular methylprednisolone therapy in hemophilic arthropathy. (3354555)
1988
31
Hemophilic arthropathy of the temporomandibular joint: review of the literature, a case report, and discussion. (3278263)
1988
32
Case report 471. Hemophilic pseudotumors (presumptive diagnosis) and hemophilic arthropathy of elbow. (3363387)
1988
33
Synovectomy of the knee for hemophilic arthropathy. (3805065)
1987
34
Hemophilic arthropathy of the upper limb. (3568484)
1987
35
Total knee arthroplasty in chronic hemophilic arthropathy. (3714579)
1986
36
Synovectomy in hemophilic arthropathy. A retrospective review of 17 cases. (3955942)
1986
37
A long-term study of hemophilic arthropathy of the knee joint on a program of Factor VIII replacement given at time of each hemarthrosis. (3917602)
1985
38
Hemophilic arthropathy complicated by polyarticular septic arthritis. (6421050)
1984
39
Hemophilic arthropathy: a literature review. (6562449)
1983
40
Nonsteroidal anti-inflammatory drugs in the treatment of hemophilic arthropathy. (7072708)
1982
41
Traumatic aneurysm of the descending geniculate artery: a complication of suction drainage in synovectomy for hemophilic arthropathy. (7428228)
1980
42
Hemophilic arthropathy in the elbow. (302402)
1977
43
Hemophilic arthropathy. Current concepts of pathogenesis and management. (849938)
1977
44
Cartilage in hemophilic arthropathy. Ultrastructural and microanalytical studies. (946396)
1976
45
Biochemical and physiological aspects of degenerative joint diseases with special reference to hemophilic arthropathy. (1053873)
1975
46
Hemophilic arthropathy. (4614656)
1974
47
Hemophilic arthropathy. (6048906)
1967
48
Hemophilic arthropathy. (13775889)
1960
49
Hemophilic arthropathy in dogs. (13836046)
1959
50
Hemophilic arthropathy. (13282597)
1956

Variations for Hemophilic Arthropathy

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Expression for genes affiliated with Hemophilic Arthropathy

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hemophilic Arthropathy

Search GEO for disease gene expression data for Hemophilic Arthropathy.

Pathways for genes affiliated with Hemophilic Arthropathy

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Sources:
50PathCards, 30KEGG, 60Thomson Reuters, 38NCBI BioSystems Database, 55Reactome, 53QIAGEN, 54R&D Systems, 57SinoBiological, 5Cell Signaling Technology
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Pathways related to Hemophilic Arthropathy according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5TNFSF11, TNFRSF11A
2
Show member pathways
Apoptosis and survival Anti apoptotic TNFs NF kB IAP pathway60
9.5TNFRSF11A, TNFSF11
39.3TNFRSF11B, TNFSF11
4
Show member pathways
9.2F9, F8
5
Show member pathways
Complement Activation, Classical Pathway38
Complement and Coagulation Cascades38
9.2F8, F9
69.0TNFSF11, TNFRSF11B, TNFRSF11A
79.0TNFRSF11A, TNFSF11, TNFRSF11B
8
Show member pathways
Apoptosis and survival TNFR1 signaling pathway60
TWEAK Signaling Pathway38
Apoptosis Modulation by HSP7038
HIV-1 Nef- Negative effector of Fas and TNF-alpha38
9.0TNFRSF11B, TNFSF11, TNFRSF11A
9
Show member pathways
9.0TNFSF11, TNFRSF11B, TNFRSF11A
109.0TNFSF11, TNFRSF11A, TNFRSF11B
11
Show member pathways
9.0TNFRSF11B, TNFSF11, TNFRSF11A
129.0PTGS2, TNFRSF11A, TNFSF11
139.0PTGS2, TNFSF11, TNFRSF11A
14
Show member pathways
8.4PTGS2, TNFRSF11B, TNFSF11, TNFRSF11A
15
Show member pathways
RANKL/RANK Signaling Pathway38
Apoptosis and survival APRIL and BAFF signaling60
8.4TNFSF11, PTGS2, TNFRSF11B, TNFRSF11A

Compounds for genes affiliated with Hemophilic Arthropathy

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Sources:
45Novoseek, 11DrugBank, 51PharmGKB, 29IUPHAR, 61Tocris Bioscience, 24HMDB, 3BitterDB
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Compounds related to Hemophilic Arthropathy according to GeneCards/GeneDecks:

(show top 50)    (show all 102)
idCompoundScoreTop Affiliating Genes
1hcc-1459.7TNFSF11, TNFRSF11B
2tributylphosphate459.6F9, F8
3rfviii459.6F9, F8
4kaolin459.5F9, F8
5teriparatide45 1110.5TNFRSF11B, TNFSF11
6tween 80459.5F8, F9
7ibandronate45 1110.4TNFRSF11B, TNFSF11
8p003459.4COMP, HFE, TNFRSF11B
9deoxypyridinoline459.4COMP, TNFSF11, TNFRSF11B
10denosumab45 1110.4TNFSF11, TNFRSF11A, TNFRSF11B
11leflunomide45 51 1111.4PTGS2, TNFSF11, COMP
12polyethylene459.4TNFRSF11A, TNFSF11, TNFRSF11B
13infliximab45 51 1111.4COMP, TNFRSF11B, TNFSF11
14raloxifene45 51 29 1112.4TNFRSF11A, TNFSF11, TNFRSF11B
15procollagen459.3TNFRSF11B, COMP, TNFSF11
16hydroxyapatite459.3TNFRSF11A, TNFSF11, TNFRSF11B
17gp 130459.3TNFRSF11B, TNFSF11, TNFRSF11A
18risedronate45 51 29 61 1113.2TNFSF11, TNFRSF11B, PTGS2
19clodronate45 51 1111.2TNFRSF11B, TNFSF11, PTGS2
20ns 39845 6110.2TNFSF11, TNFRSF11B, PTGS2
211,25 dihydroxy vitamin d3459.2TNFRSF11B, TNFRSF11A, TNFSF11
22laccer459.2TNFRSF11A, TNFSF11
23celecoxib45 61 29 51 24 1114.2TNFRSF11B, TNFSF11, PTGS2
24desmopressin45 61 29 1112.1F8, F9, PTGS2
25acetaminophen45 3 51 24 1113.1F9, PTGS2, F8
26urea45 24 1111.0TNFRSF11B, TNFSF11, F9
27homocysteine45 249.9F8, TNFRSF11B, F9
28etanercept45 51 1110.9TNFSF11, PTGS2, COMP, TNFRSF11B
29latex458.9F8, TNFSF11, F9
30prostaglandin458.9TNFRSF11A, TNFRSF11B, PTGS2, TNFSF11
31agarose458.9COMP, F8, HFE
32thromboxane a245 249.9TNFSF11, PTGS2, F8
33prednisolone45 29 1110.8COMP, F8, TNFRSF11B, F9
34pge2458.7TNFRSF11A, PTGS2, TNFSF11, TNFRSF11B
35tgf beta1458.7COMP, F8, TNFRSF11B
36gold458.7F8, HFE, TNFRSF11B
37iron45 249.5HFE, F8, PTGS2, TNFRSF11B
38cyclosporin a45 29 6110.4F9, TNFRSF11B, TNFSF11, F8
39aspartate458.3TNFRSF11B, F8, COMP, HFE, F9
40glucose458.3HFE, COMP, F9, F8, TNFRSF11B
41heparin45 29 24 1111.3TNFRSF11B, TNFSF11, F8, F9
42creatinine458.2COMP, F8, F9, TNFRSF11B, TNFSF11
43vegf458.0F8, TNFRSF11B, PTGS2, TNFRSF11A, TNFSF11
44nitric oxide45 24 1110.0F8, PTGS2, TNFRSF11A, TNFSF11, TNFRSF11B
45cysteine457.7HFE, F9, TNFSF11, TNFRSF11B, F8, COMP
46calcium45 51 24 1110.7COMP, F8, TNFRSF11B, TNFSF11, F9, TNFRSF11A
47tyrosine457.7F9, F8, HFE, TNFSF11, TNFRSF11B, TNFRSF11A
48dexamethasone45 51 29 1110.6F8, TNFSF11, PTGS2, TNFRSF11B, TNFRSF11A, F9
49lipid457.4HFE, COMP, TNFRSF11B, TNFSF11, TNFRSF11A, F9
50estrogen457.2F8, PTGS2, TNFRSF11B, TNFSF11, TNFRSF11A, F9

GO Terms for genes affiliated with Hemophilic Arthropathy

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Sources:
16Gene Ontology
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Cellular components related to Hemophilic Arthropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.2COMP, F8, TNFRSF11B, TNFSF11
2extracellular regionGO:0055767.5COMP, F8, TNFRSF11B, TNFSF11, F9

Biological processes related to Hemophilic Arthropathy according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of fever generation by positive regulation of prostaglandin secretionGO:0718129.7TNFSF11, TNFRSF11A
2positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signalingGO:0718489.7TNFRSF11A, TNFSF11
3TNFSF11-mediated signaling pathwayGO:0718479.7TNFRSF11A, TNFSF11
4mammary gland alveolus developmentGO:0607499.6TNFSF11, TNFRSF11A
5monocyte chemotaxisGO:0025489.6TNFSF11, TNFRSF11A
6osteoclast differentiationGO:0303169.5TNFSF11, TNFRSF11A
7ossificationGO:0015039.5TNFSF11, TNFRSF11A
8response to tumor necrosis factorGO:0346129.5PTGS2, TNFRSF11A
9blood coagulation, intrinsic pathwayGO:0075979.3F9, F8
10tumor necrosis factor-mediated signaling pathwayGO:0332099.2TNFSF11, TNFRSF11A

Products for genes affiliated with Hemophilic Arthropathy

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Sources for Hemophilic Arthropathy

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet