MCID: HMP018
MIFTS: 32

Hemophilic Arthropathy malady

Category: Rare diseases

Aliases & Classifications for Hemophilic Arthropathy

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Aliases & Descriptions for Hemophilic Arthropathy:

Name: Hemophilic Arthropathy 45 65

Classifications:



External Ids:

UMLS65 C0263725

Summaries for Hemophilic Arthropathy

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MalaCards based summary: Hemophilic Arthropathy is related to hepatitis and breast cancer. An important gene associated with Hemophilic Arthropathy is HFE (Hemochromatosis), and among its related pathways are Rheumatoid arthritis and Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway. Affiliated tissues include breast, brain and kidney, and related mouse phenotypes are no phenotypic analysis and limbs/digits/tail.

Related Diseases for Hemophilic Arthropathy

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Graphical network of the top 20 diseases related to Hemophilic Arthropathy:



Diseases related to hemophilic arthropathy

Symptoms for Hemophilic Arthropathy

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Drugs & Therapeutics for Hemophilic Arthropathy

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Drugs for Hemophilic Arthropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
RopivacaineapprovedPhase 465084057-95-471273, 175805
Synonyms:
(2S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide
(2S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide hydrochloride
(S)-(−)-1-propyl-2',6'-pipecoloxylidide
(S)-ropivacaine
84057-95-4
98717-15-8
AC1L41QM
AC1L41QN
BIDD:GT0203
C07532
C17H26N2O.HCl
CHEBI:8890
CHEMBL1077896
CID175804
CID175805
CPD000469137
D08490
I14-176
L-N-n-propylpipecolic acid-2,6-xylidide
LS-113954
 
MLS001401363
MolPort-003-983-292
NCGC00164597-01
Naropin
Naropin (TN)
ROPIVACAINE HCl
Ropivacaina
Ropivacaina [INN-Spanish]
Ropivacaina [Spanish]
Ropivacaine
Ropivacaine Hydrochloride
Ropivacaine [INN]
Ropivacaine hydrochloride
Ropivacaine monohydrochloride
Ropivacainum
Ropivacainum [INN-Latin]
S-Ropivacaine
SAM001246524
SMR000469137
ST51051452
ropivacaine monohydrochloride,
ropivacaine monohydrochloride, (S)-isomer
2
TriamcinoloneapprovedPhase 4448124-94-731307
Synonyms:
(8S,9R,10S,11S,13S,14S,16R,17S)-9-fluoro-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
11-beta,16-alpha,17-alpha,21-Tetrahydroxy-9-alpha-fluoro-1,4-pregnadiene-3,20-dione
11.Beta.,16.alpha.,17.alpha., 21-Tetrahydroxy-9.alpha.-fluoro-1,4-pregnadiene-3,20-dione
11.beta.,16.alpha.,17.alpha.,21-Tetrahydroxy-9.alpha.-fluoro-1,4-pregnadiene-3,20-dione
11beta,16alpha,17alpha,21-Tetrahydroxy-9alpha-fluoro-1,4-pregnadiene-3,20-dione
124-94-7
4-08-00-03629 (Beilstein Handbook Reference)
83474-03-7
9-Fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9-Fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9-alpha-Fluoro-11-beta,16-alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9-alpha-Fluoro-16-alpha-hydroxyprednisolone
9.Alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahy
9.Alpha.-Fluoro-11.beta.,16.alpha.,17.alpha., 21-tetrahydroxypregna-1,4-diene-3,20-d
9.alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahydroxy-1,4-pregnadiene-3,20-dione
9.alpha.-Fluoro-11.beta.,16.alpha.,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9.alpha.-Fluoro-11.beta.,16.alpha.,17.alpha.,21-tetrahydroxypregna-1,4-diene-3,20-dione
9.alpha.-Fluoro-16.alpha.-hydroxyprednisolone
9alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxy-1,4-pregnadiene-3,20-dione
9alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9alpha-Fluoro-11beta,16alpha,17alpha,21-tetrahydroxypregna-1,4-diene-3,20-dione
9alpha-Fluoro-16alpha-hydroxyprednisolone
9α-fluoro-16α-hydroxyprednisolone
AC-2072
AC1L1LDH
AC1Q5HJC
Adcortyl
Allernaze
Aristocort
Aristocort A
Aristocort Tablets
Aristogel
Aristospan
Azmacort
BPBio1_000154
BRD-K77554836-001-03-3
BRN 2341955
BSPBio_000140
Bio-0662
C21H27FO6
CHEMBL1451
CID31307
CL 19823
Celeste
Cinolone
Cinolone-T
D00385
D014221
DB00620
Delphicort
EINECS 204-718-7
EU-0101179
Fluoxiprednisolone
Fluoxyprednisolone
Flutex
Fougera
HMS1568G22
HMS2090D12
HSDB 3194
Kenacort
Kenacort (TN)
Kenacort-A
Kenacort-AG
Kenacort-Ag
Kenalog
Kenalog in Orabase
Kenalog-10
Kenalog-40
Kenalog-H
LS-698
Ledercort
Lopac0_001179
MLS000028542
MLS001066543
 
MLS002695935
MolPort-002-528-981
Mycolog
NCGC00021580-03
NCGC00021580-04
NCGC00021580-05
NCGC00021580-06
NCGC00021580-07
NCI60_000750
NSC 13397
NSC13397
Nasacort
Nasacort Aq
Nasacort Hfa
Omcilon
Omicilon
Oracort
Oralone
Orion
Polcortolon
Pregna-1,4-diene-3,20-dio
Pregna-1,4-diene-3,20-dione, 9-fluoro-11,16,17,21-tetrahydroxy-, (11beta,16alpha)
Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,16alpha,17,21-tetrahydroxy- (8CI)
Prestwick0_000120
Prestwick1_000120
Prestwick2_000120
Prestwick3_000120
Prestwick_438
Rodinolone
S1933_Selleck
SK-Triamcinolone
SMP1_000300
SMR000058333
SPBio_002079
Sk-Triamcinolone
T6376_SIGMA
TRIAMCINOLONE (SEE ALSO TRIAMCINOLONE ACETONIDE (76-25-5) AND TRIAMCINOLONE DIACETATE (67-78-7))
Tiamcinolonum
Tiamcinolonum [INN-Latin]
Tri-Nasal
Triacet
Triacort
Triam-Tablinen
Triamcet
Triamcinalone
Triamcinlon
Triamcinolon
Triamcinolona
Triamcinolona [INN-Spanish]
Triamcinolone (JP15/USP/INN)
Triamcinolone Acetonide
Triamcinolone [USAN:INN:BAN:JAN]
Triamcinolone acetonide
Triamcinolone diacetate
Triamcinolone hexacetonide
Triamcinolonum
Triamcinolonum [INN]
Trianex
Triatex
Tricortale
Triderm
Triesence
Trilone
Tristoject
Trymex
UNII-1ZK20VI6TY
Vetalog
Volon
Volon A
WLN: L E5 B666 OV KU MUTJ A1 BF CQ E1 FV1Q FQ GQ
ZINC03882036
droxypregna-1,4-diene-3,20-dione
ione
nchembio.2007.53-comp7
triamcinolone
3
HyaluronanapprovedPhase 43629067-32-7, 9004-61-953477741, 24759
Synonyms:
Hyaluronate
Hyaluronic acid
Hyaluronic acid sodium salt
Hylartil
Hyruan Plus
Luronit
Macronan
 
Mucoitin
Nutra-HAF
Q 5AQ
Sepracoat
Sepragel Sinus
Sodium hyaluronate
Sofast
Synvisc
4
Bevacizumabapproved, investigationalPhase 41875216974-75-3
Synonyms:
216974-75-3
Avastin
Avastin (TN)
Bevacizumab
Bevacizumab (genetical recombination)
 
Bevacizumab (genetical recombination) (JAN)
D06409
R-435
anti-VEGF monoclonal antibody
antiVEGF
bevacizumab
5Triamcinolone hexacetonidePhase 4448
6Triamcinolone diacetatePhase 4448
7triamcinolone acetonidePhase 4448
8Factor VIIIPhase 4272
9HylanPhase 446
10Angiogenesis Modulating AgentsPhase 43611
11Angiogenesis InhibitorsPhase 43688
12Protective Agents5651
13Viscosupplements267
14Adjuvants, Immunologic1783
15Immunologic Factors18483
16Hemostatics1082
17Coagulants1042
18Thrombin269
19Soy BeanNutraceutical455

Interventional clinical trials:

(show all 22)
idNameStatusNCT IDPhase
1Viscosupplementation in Patients With Hemophilic ArthropathyCompletedNCT01748201Phase 4
2Impact of Conservative Treatment by Custom-made Orthoses in Patients With Haemophilic Ankle ArthropathyCompletedNCT00638001Phase 4
3Intra-articular Bevacizumab for Recurrent Hemarthroses at Target Joints With Chronic Hemophilic SynovitisRecruitingNCT02060305Phase 4
4Validation of Ultrasound as a Diagnostic Tool for Assessment of Hemophilic Arthropathy of Knees and AnklesRecruitingNCT01232634Phase 2
5Platelet-Rich Plasma Intra-Articular Injection in Treating Hemophilic ArthropathyCompletedNCT02601170
6Bilateral Deficit Phenomenon in Patients With Haemophilic ArthropathyCompletedNCT02165462
7Manual Therapy in Haemophilic Arthropathy of the KneeCompletedNCT02198014
8Physiotherapy in the Haemophilic Arthropathy of the Elbow.CompletedNCT02198040
9Gait Evaluation in Haemophiliac PatientsCompletedNCT00824798
10Study to Evaluate the Use of Ultrasound in the Diagnosis of Hemophilic Joint DiseaseCompletedNCT00212485
11Epidemiological Study on Haemophilia Care and Orthopaedic Status in Developing CountriesCompletedNCT01503567
12Myofascial Therapy in Patients With Hemophilic ArthropathyRecruitingNCT02433782
13Efficacy and Safety of Shea Nut Oil in Hemophilic ArthropathyRecruitingNCT02569359
14TGA (Thrombin Generation Assay) and Prophylaxis in HaemophiliaRecruitingNCT02781766
15Assessment of Proprioceptive and Functional Characteristics in Patients With HemophiliaRecruitingNCT02165592
16Exploratory Pilot Study of Physical Activity Monitoring in Adult Patients With Haemophilia A by Means of AccelerometryActive, not recruitingNCT02253693
17Joint Outcome Study Continuation for Children With Severe Factor VIII DeficiencyEnrolling by invitationNCT01000844
18Personalized Prophylactic Treatment With Advate® in Severe or Moderate Haemophilia A PatientsNot yet recruitingNCT02622646
19Ultrasonography in Hemophilic Joint Disease and Serum MarkersNot yet recruitingNCT02634918
20Biomechanical Determinants and Patterns Associated to the Pathophysiological Cascade of Ankle Arthropathy in Children With Haemophilia: Non-invasive In-vivo Measurement of Foot Joints in Children With Haemophilia During Gait.Not yet recruitingNCT02229331
21Osteoporosis and MRI Study in HemophiliaTerminatedNCT01460147
22Individually Tailored Prophylaxis in Patients With Severe Hemophilia ATerminatedNCT00995046

Search NIH Clinical Center for Hemophilic Arthropathy

Genetic Tests for Hemophilic Arthropathy

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Anatomical Context for Hemophilic Arthropathy

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MalaCards organs/tissues related to Hemophilic Arthropathy:

33
Breast, Brain, Kidney, Thyroid, Prostate, T cells, Monocytes

Animal Models for Hemophilic Arthropathy or affiliated genes

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MGI Mouse Phenotypes related to Hemophilic Arthropathy:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.6HFE, PTGS2, TNFRSF11A, TNFSF11
2MP:00053718.4HFE, TNFRSF11A, TNFRSF11B, TNFSF11
3MP:00053908.0PTGS2, TNFRSF11A, TNFRSF11B, TNFSF11
4MP:00107687.6HFE, PTGS2, TNFRSF11A, TNFRSF11B, TNFSF11
5MP:00053787.6HFE, PTGS2, TNFRSF11A, TNFRSF11B, TNFSF11
6MP:00053877.4HFE, PTGS2, TNFRSF11A, TNFRSF11B, TNFSF11
7MP:00053977.2HFE, PTGS2, TNFRSF11A, TNFRSF11B, TNFSF11

Publications for Hemophilic Arthropathy

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Articles related to Hemophilic Arthropathy:

(show top 50)    (show all 132)
idTitleAuthorsYear
1
Ubiquitin-mediated regulation of the E3 ligase GP78 by MGRN1 in trans affects mitochondrial homeostasis. (26743086)
2016
2
Gastrointestinal Disorder Associated with Olmesartan Mimics Autoimmune Enteropathy. (26101883)
2015
3
Knockdown of ubiquitin associated protein 2-like inhibits the growth and migration of prostate cancer cells. (25069639)
2014
4
Prognostic value of CD44 expression in non-small cell lung cancer: a systematic review. (25120740)
2014
5
A Novel Nonsense Mutation in the EpCAM Gene in a Patient With Congenital Tufting Enteropathy. (24048167)
2014
6
Identification of prognostic biomarkers in hepatitis B virus-related hepatocellular carcinoma and stratification by integrative multi-omics analysis. (24859455)
2014
7
HEATR2 plays a conserved role in assembly of the ciliary motile apparatus. (25232951)
2014
8
Childhood ADHD and risk for substance dependence in adulthood: a longitudinal, population-based study. (25162629)
2014
9
Topoisomerase III^ binding protein 1 c.*229C>T (rs115160714) gene polymorphism and endometrial cancer risk. (24346708)
2014
10
A migrant study of pubertal timing and tempo in British-Bangladeshi girls at varying risk for breast cancer. (25398700)
2014
11
RelB/p50 regulates TNF production in LPS-stimulated dendritic cells and macrophages. (23394901)
2013
12
Expression of FoxM1 is required for the proliferation of medulloblastoma cells and indicates worse survival of patients. (21918172)
2011
13
Frequency of dental caries in four historical populations from the chalcolithic to the middle ages. (22145000)
2011
14
Pro370Leu myocilin mutation in a Chinese pedigree with juvenile-onset open angle glaucoma. (21677793)
2011
15
Syngeneic donor hematopoietic stem cell transplantation is associated with high rates of engraftment syndrome. (20870027)
2011
16
Lobular capillary hemangioma in the soft tissue of the finger: sonographic findings. (20428860)
2010
17
Plasmacytoma in the thyroid. (21294490)
2010
18
Associations between the C677T and A1298C polymorphisms of MTHFR and the efficacy and toxicity of methotrexate in rheumatoid arthritis: a meta-analysis. (20067328)
2010
19
Brain metabolic correlates of cerebrospinal fluid beta-amyloid 42 and tau in Alzheimer's disease. (19439965)
2009
20
A structural variant of the human interferon-gamma gene. (19254267)
2009
21
Association of the plasminogen activator inhibitor-1 gene 4G/5G polymorphism with ST elevation acute myocardial infarction in young patients. (19401121)
2009
22
Application of IHS criteria to headache attributed to spontaneous intracranial hypotension in a large population. (19291244)
2009
23
Visualization of polarized membrane type 1 matrix metalloproteinase activity in live cells by fluorescence resonance energy transfer imaging. (18441011)
2008
24
Autoantibodies in breast cancer: their use as an aid to early diagnosis. (17347129)
2007
25
Cluster headache in women. (17367591)
2007
26
Multiple less common genetic variants explain the association of the cholesteryl ester transfer protein gene with coronary artery disease. (17512363)
2007
27
Protein kinase C-dependent enhancement of activity of rat brain NCKX2 heterologously expressed in HEK293 cells. (17038313)
2006
28
Early successful orchidopexy does not prevent from developing azoospermia. (17081328)
2006
29
Effects of melatonin administration on the clinical course of adrenocortical disease in domestic ferrets. (17144819)
2006
30
Living with pityriasis rubra pilaris. (16294947)
2005
31
Assessment of visual function in children with methylmalonic aciduria and homocystinuria. (15944903)
2005
32
Primary malignant lymphoma of the breast: clinicopathological study of nine cases. (15101719)
2004
33
The virtual synapse what is its contribution to understanding cholinergic neural transmission?]. (15199663)
2004
34
Quantitative plasma hypermethylated DNA markers of undifferentiated nasopharyngeal carcinoma. (15073117)
2004
35
Resistance of decoy PNA-DNA chimeras to enzymatic degradation in cellular extracts and serum. (12688679)
2003
36
The lutropin/choriogonadotropin receptor, a 2002 perspective. (11943741)
2002
37
Hepatitis C virus NS5A protein binds TBP and p53, inhibiting their DNA binding and p53 interactions with TBP and ERCC3. (12379483)
2002
38
Loss of fragile histidine triad (FHIT) expression and microsatellite instability in periocular sebaceous gland carcinoma in patients with Muir-Torre syndrome. (12095833)
2002
39
Synthesis and receptor docking studies of N-substituted indole-2-carboxylic acid esters as a search for COX-2 selective enzyme inhibitors. (11672885)
2001
40
A comparative study of peptide models of the alpha-domain of alpha-lactalbumin, lysozyme, and alpha-lactalbumin/lysozyme chimeras allows the elucidation of critical factors that contribute to the ability to form stable partially folded states. (11329282)
2001
41
Alpha-melanocyte-stimulating hormone inhibits the nuclear transcription factor NF-kappa B activation induced by various inflammatory agents. (9743348)
1998
42
AAC-11, a novel cDNA that inhibits apoptosis after growth factor withdrawal. (9307294)
1997
43
Human cervical cancer. Retinoids, interferon and human papillomavirus. (7544060)
1995
44
Covert bronchogenic cyst as a cause of life-threatening cardiopulmonary impairment. (7644402)
1995
45
Mapping basigin (BSG), a member of the immunoglobulin superfamily, to 19p13.3. (8404035)
1993
46
Phenotypic characterization of monocytes and macrophages from CAPD patients. (2252754)
1990
47
Incidental Mirizzi syndrome. (3427955)
1987
48
Neurogenic hypertension after depletion of norepinephrine in anterior hypothalamus induced by 6-hydroxydopamine administration into the ventral pons: role of serotonin. (6405300)
1983
49
Mucolipidosis III is genetically heterogeneous. (6961420)
1982
50
Pityriasis Lichenoides: Case for Diagnosis. (19990188)
1935

Variations for Hemophilic Arthropathy

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Expression for genes affiliated with Hemophilic Arthropathy

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Search GEO for disease gene expression data for Hemophilic Arthropathy.

Pathways for genes affiliated with Hemophilic Arthropathy

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Pathways related to Hemophilic Arthropathy according to GeneCards Suite gene sharing:

(show all 11)
idSuper pathwaysScoreTop Affiliating Genes
19.3TNFRSF11A, TNFSF11
2
Show member pathways
9.3TNFRSF11A, TNFSF11
39.1TNFRSF11B, TNFSF11
48.8PTGS2, TNFRSF11A, TNFSF11
58.5TNFRSF11A, TNFRSF11B, TNFSF11
6
Show member pathways
8.5TNFRSF11A, TNFRSF11B, TNFSF11
7
Show member pathways
8.5TNFRSF11A, TNFRSF11B, TNFSF11
8
Show member pathways
8.5TNFRSF11A, TNFRSF11B, TNFSF11
98.5TNFRSF11A, TNFRSF11B, TNFSF11
108.5TNFRSF11A, TNFRSF11B, TNFSF11
11
Show member pathways
8.0PTGS2, TNFRSF11A, TNFRSF11B, TNFSF11

GO Terms for genes affiliated with Hemophilic Arthropathy

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Biological processes related to Hemophilic Arthropathy according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signalingGO:00718489.9TNFRSF11A, TNFSF11
2TNFSF11-mediated signaling pathwayGO:00718479.9TNFRSF11A, TNFSF11
3response to radiationGO:00093149.9PTGS2, TNFRSF11A
4response to cytokineGO:00340979.8PTGS2, TNFRSF11A
5osteoclast differentiationGO:00303169.8TNFRSF11A, TNFSF11
6ossificationGO:00015039.6TNFRSF11A, TNFSF11
7monocyte chemotaxisGO:00025489.5TNFRSF11A, TNFSF11
8response to tumor necrosis factorGO:00346129.5PTGS2, TNFRSF11A
9apoptotic signaling pathwayGO:00971909.4TNFRSF11A, TNFRSF11B
10regulation of cell proliferationGO:00421279.1PTGS2, TNFRSF11B
11inflammatory responseGO:00069548.6PTGS2, TNFRSF11A, TNFRSF11B
12response to lipopolysaccharideGO:00324968.2PTGS2, TNFRSF11A, TNFRSF11B

Sources for Hemophilic Arthropathy

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet