MCID: HMP018
MIFTS: 29

Hemophilic Arthropathy malady

Summaries for Hemophilic Arthropathy

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63Wikipedia, 32MalaCards
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Wikipedia:63 Haemophilia (/hiːməˈfɪliə/; also spelled hemophilia in North America, from the Greek haima... more...

MalaCards: Hemophilic Arthropathy is related to arthropathy and osteoporosis. An important gene associated with Hemophilic Arthropathy is COMP (cartilage oligomeric matrix protein), and among its related pathways are Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway and Osteoblast Signaling. The compounds glucose and acetaminophen have been mentioned in the context of this disorder. Related mouse phenotypes are limbs/digits/tail and liver/biliary system.

Aliases & Classifications for Hemophilic Arthropathy

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42NIH Rare Diseases, 60UMLS
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Aliases & Descriptions:

hemophilic arthropathy 42 60


Related Diseases for Hemophilic Arthropathy

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17GeneCards, 18GeneDecks
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Diseases related to Hemophilic Arthropathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 90)
idRelated DiseaseScoreTop Affiliating Genes
1arthropathy31.7HFE, F8, TNFRSF11B, TNFSF11, F9, COMP
2osteoporosis30.4TNFRSF11A, TNFSF11, TNFRSF11B
3hemarthrosis30.2F9, F8
4factor viii deficiency30.2F9, F8
5leukemia30.2HFE, F8, F9
6osteoarthritis30.2COMP, TNFRSF11A, TNFSF11, TNFRSF11B, HFE, PTGS2
7arthritis30.2COMP, TNFRSF11A, TNFSF11, TNFRSF11B, HFE, PTGS2
8hemophilia10.3
9septic arthritis10.2
10poliomyelitis10.2
11chondrosarcoma10.0COMP
12paget's disease of bone10.0TNFRSF11A
13galactosemia10.0HFE
14factor xii deficiency10.0F9
15wilson disease10.0HFE
16coronary heart disease10.0HFE
17root resorption10.0TNFRSF11B
18sickle cell disease10.0F9
19hypogonadism10.0HFE
20acute myocardial infarction10.0TNFSF11
21alpha thalassemia10.0HFE
22lung cancer10.0PTGS2
23bladder carcinoma10.0F9
24hemorrhagic disease10.0F9
25protein c deficiency10.0F9
26periapical granuloma10.0TNFSF11
27renal osteodystrophy10.0TNFRSF11B
28obesity10.0COMP, HFE
29anorexia nervosa10.0TNFRSF11B
30factor v deficiency10.0F8
31myelofibrosis10.0F8
32cardiac tamponade10.0F8
33colorectal cancer10.0PTGS2
34sarcoma10.0F8
35multiple myeloma10.0TNFRSF11B, TNFSF11
36cholesteatoma10.0TNFSF11, TNFRSF11B
37osteosclerosis10.0TNFRSF11B, TNFSF11
38melanoma10.0TNFRSF11B, TNFSF11
39thromboembolism10.0F8, F9
40aortic valve stenosis10.0TNFSF11, TNFRSF11B
41thrombophilia10.0F9, F8
42factor xi deficiency10.0F8, F9
43adenoameloblastoma10.0TNFSF11, TNFRSF11B
44factor vii deficiency10.0F9, F8
45diabetes mellitus10.0F8, HFE
46ankylosing spondylitis10.0TNFRSF11B, TNFSF11
47bernard-soulier syndrome10.0F9, F8
48pain agnosia10.0PTGS2, F9
49viral hepatitis10.0HFE, F8
50hemophilia b10.0F8, F9

Graphical network of the top 20 diseases related to Hemophilic Arthropathy:



Diseases related to hemophilic arthropathy

Clinical Features for Hemophilic Arthropathy

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Drugs & Therapeutics for Hemophilic Arthropathy

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Hemophilic Arthropathy

Drug clinical trials:

Search ClinicalTrials for Hemophilic Arthropathy

Search NIH Clinical Center for Hemophilic Arthropathy

Search CenterWatch for Hemophilic Arthropathy

Genetic Tests for Hemophilic Arthropathy

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Anatomical Context for Hemophilic Arthropathy

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Animal Models for Hemophilic Arthropathy or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Hemophilic Arthropathy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053719.8HFE, COMP
2MP:00053708.7PTGS2, HFE, TNFRSF11A, F9
3MP:00053908.6COMP, TNFRSF11A, TNFSF11, TNFRSF11B
4MP:00053787.5COMP, TNFRSF11A, TNFSF11, TNFRSF11B, HFE, PTGS2
5MP:00053767.0F9, TNFRSF11A, TNFSF11, F8, HFE, PTGS2
6MP:00053976.9F9, TNFRSF11A, TNFSF11, TNFRSF11B, F8, HFE
7MP:00107686.8F9, TNFRSF11A, TNFSF11, TNFRSF11B, F8, HFE
8MP:00053876.6PTGS2, COMP, F9, TNFRSF11A, TNFSF11, TNFRSF11B

Publications for Hemophilic Arthropathy

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Genetic Variations for Hemophilic Arthropathy

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Expression for genes affiliated with Hemophilic Arthropathy

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hemophilic Arthropathy

Search GEO for disease gene expression data for Hemophilic Arthropathy.

Pathways for genes affiliated with Hemophilic Arthropathy

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12EMD Millipore, 37NCBI BioSystems Database, 53Reactome, 52R&D Systems, 51QIAGEN, 55SinoBiological, 29KEGG, 4Cell Signaling Technology
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Pathways related to Hemophilic Arthropathy according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
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9.5TNFSF11, TNFRSF11A
29.3TNFSF11, TNFRSF11B
3
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9.2F8, F9
4
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9.0TNFRSF11B, TNFSF11, TNFRSF11A
59.0TNFRSF11B, TNFSF11, TNFRSF11A
6
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9.0TNFRSF11B, TNFSF11, TNFRSF11A
79.0TNFRSF11A, TNFSF11, TNFRSF11B
8
Transcription Role of VDR in regulation of genes involved in osteoporosis
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9.0TNFRSF11A, TNFSF11, TNFRSF11B
9
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9.0TNFRSF11A, TNFSF11, TNFRSF11B
109.0PTGS2, TNFSF11, TNFRSF11A
119.0TNFRSF11A, TNFSF11, PTGS2
12
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8.9F8, F9, COMP
13
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8.4PTGS2, TNFRSF11B, TNFSF11, TNFRSF11A
14
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8.4TNFRSF11A, TNFSF11, TNFRSF11B, PTGS2

Compounds for genes affiliated with Hemophilic Arthropathy

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Sources:
44Novoseek, 2BitterDB, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Hemophilic Arthropathy according to GeneCards/GeneDecks:

(show top 50)    (show all 87)
idCompoundScoreTop Affiliating Genes
1glucose4410.4COMP
2acetaminophen44 2 49 11 2414.4F9
3pge24410.2PTGS2
4p003449.9COMP, HFE
5hcc-1449.7TNFSF11, TNFRSF11B
6estrogen449.7F9, F8
7tributylphosphate449.6F8, F9
8laccer449.6TNFRSF11A, TNFSF11
9rfviii449.6F9, F8
10teriparatide44 1110.6TNFRSF11B, TNFSF11
11tween 80449.6F8, F9
12kaolin449.6F8, F9
13ibandronate44 1110.5TNFSF11, TNFRSF11B
14deoxypyridinoline449.4TNFSF11, COMP, TNFRSF11B
15denosumab44 1110.4TNFRSF11B, TNFSF11, TNFRSF11A
16polyethylene449.4TNFRSF11A, TNFRSF11B, TNFSF11
17leflunomide49 44 1111.4PTGS2, TNFSF11, COMP
18infliximab44 49 1111.4COMP, TNFRSF11B, TNFSF11
19raloxifene44 28 49 1112.4TNFRSF11B, TNFSF11, TNFRSF11A
20procollagen449.3COMP, TNFSF11, TNFRSF11B
21hydroxyapatite449.3TNFRSF11A, TNFSF11, TNFRSF11B
22gp 130449.3TNFRSF11A, TNFSF11, TNFRSF11B
23risedronate44 59 49 28 1113.2TNFRSF11B, TNFSF11, PTGS2
24clodronate44 49 1111.2TNFSF11, TNFRSF11B, PTGS2
25lenalidomide44 1110.2TNFSF11, PTGS2
26ns 39844 5910.2TNFSF11, TNFRSF11B, PTGS2
27celecoxib44 59 28 49 11 2414.2TNFSF11, TNFRSF11B, PTGS2
281,25 dihydroxy vitamin d3449.2TNFRSF11B, TNFRSF11A, TNFSF11
29desmopressin44 59 28 1112.1F9, F8, PTGS2
30urea44 11 2411.0F9, TNFRSF11B, TNFSF11
31iron44 2410.0HFE, PTGS2, F8
32etanercept44 49 1110.9PTGS2, TNFRSF11B, TNFSF11, COMP
33latex448.9F9, TNFSF11, F8
34homocysteine44 249.9F9, TNFRSF11B, F8
35prostaglandin448.9PTGS2, TNFRSF11A, TNFSF11, TNFRSF11B
36thromboxane a244 249.9TNFSF11, F8, PTGS2
37prednisolone44 28 1110.8COMP, F8, TNFRSF11B, F9
38tgf beta1448.8F8, COMP, TNFRSF11B
39gold448.7HFE, F8, TNFRSF11B
40cyclosporin a44 28 5910.4TNFSF11, F9, TNFRSF11B, F8
41aspartate448.3TNFRSF11B, HFE, COMP, F9, F8
42creatinine448.2F8, COMP, F9, TNFSF11, TNFRSF11B
43heparin44 28 11 2411.2F8, F9, TNFRSF11B, TNFSF11
44dexamethasone44 49 28 1111.0PTGS2, TNFSF11, F8, TNFRSF11B, F9
45vegf448.0PTGS2, F8, TNFRSF11B, TNFSF11, TNFRSF11A
46nitric oxide44 11 2410.0TNFRSF11B, PTGS2, F8, TNFSF11, TNFRSF11A
47cysteine447.7COMP, F8, HFE, TNFSF11, F9, TNFRSF11B
48tyrosine447.6HFE, F9, TNFRSF11A, TNFSF11, TNFRSF11B, F8
49lipid447.4TNFRSF11A, COMP, TNFSF11, TNFRSF11B, F8, HFE
50calcium44 49 11 2410.1F8, F9, TNFRSF11A, TNFRSF11B, TNFSF11, COMP

GO Terms for genes affiliated with Hemophilic Arthropathy

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16Gene Ontology
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Cellular components related to Hemophilic Arthropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.2F8, TNFRSF11B, TNFSF11, COMP
2extracellular regionGO:0055767.5F8, TNFRSF11B, TNFSF11, F9, COMP

Biological processes related to Hemophilic Arthropathy according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of fever generation by positive regulation of prostaglandin secretionGO:0718129.7TNFSF11, TNFRSF11A
2TNFSF11-mediated signaling pathwayGO:0718479.7TNFSF11, TNFRSF11A
3positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signalingGO:0718489.6TNFSF11, TNFRSF11A
4mammary gland alveolus developmentGO:0607499.6TNFSF11, TNFRSF11A
5monocyte chemotaxisGO:0025489.5TNFRSF11A, TNFSF11
6tumor necrosis factor-mediated signaling pathwayGO:0332099.5TNFSF11, TNFRSF11A
7osteoclast differentiationGO:0303169.4TNFSF11, TNFRSF11A
8response to tumor necrosis factorGO:0346129.3PTGS2, TNFRSF11A
9blood coagulation, intrinsic pathwayGO:0075979.2F8, F9

Products for genes affiliated with Hemophilic Arthropathy

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Sources for Hemophilic Arthropathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet