MCID: HMP018
MIFTS: 41

Hemophilic Arthropathy malady

Rare diseases category
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Summaries for Hemophilic Arthropathy

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Wikipedia:65 Haemophilia (/hi?m??f?li?/; also spelled hemophilia in North America, from the Greek haima ????... more...

MalaCards based summary: Hemophilic Arthropathy is related to arthropathy and osteoporosis. An important gene associated with Hemophilic Arthropathy is COMP (cartilage oligomeric matrix protein), and among its related pathways are Rheumatoid arthritis and Apoptosis and survival Anti apoptotic TNFs NF kB Bcl 2 pathway. The compounds hcc-1 and tributylphosphate have been mentioned in the context of this disorder. Affiliated tissues include bone, and related mouse phenotypes are liver/biliary system and limbs/digits/tail.

Aliases & Classifications for Hemophilic Arthropathy

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Hemophilic Arthropathy, Aliases & Descriptions:

Name: Hemophilic Arthropathy 42 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Related Diseases for Hemophilic Arthropathy

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Diseases related to Hemophilic Arthropathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 78)
idRelated DiseaseScoreTop Affiliating Genes
1arthropathy30.8HFE, COMP, F8, TNFRSF11B, TNFSF11, F9
2osteoporosis30.5TNFRSF11B, TNFSF11, TNFRSF11A
3hemarthrosis30.5F9, F8
4osteoarthritis29.5TNFRSF11A, TNFSF11, TNFRSF11B, PTGS2, COMP, HFE
5arthritis29.5TNFRSF11A, TNFSF11, TNFRSF11B, PTGS2, COMP, HFE
6paget's disease of bone10.5TNFRSF11A
7factor xii deficiency10.5F9
8osteomyelitis10.4TNFSF11
9hemophilia10.4
10aneurysm10.4
11periapical granuloma10.4TNFSF11
12factor v deficiency10.3F8
13cardiac tamponade10.3F8
14leukemia10.2
15septic arthritis10.2
16poliomyelitis10.2
17pain agnosia10.2F9, PTGS2
18osteosclerosis10.2TNFSF11, TNFRSF11B
19aortic valve stenosis10.1TNFSF11, TNFRSF11B
20gingivitis10.1TNFRSF11B, TNFSF11
21factor xi deficiency10.1F9, F8
22ameloblastoma10.1TNFRSF11B, TNFSF11
23hemorrhagic disease10.1F9, F8
24von willebrand's disease10.1F9, F8
25factor vii deficiency10.1F9, F8
26factor viii deficiency10.1F8, F9
27cholesteatoma10.1TNFRSF11B, TNFSF11
28ankylosing spondylitis10.1TNFSF11, TNFRSF11B
29bernard-soulier syndrome10.1F9, F8
30hemophilia b10.1F8, F9
31glanzmann's thrombasthenia10.1F8, F9
32hyperparathyroidism10.1TNFRSF11B, TNFSF11
33thrombophilia10.1F8, F9
34thromboembolism10.0F9, F8
35periodontitis10.0TNFSF11, TNFRSF11B
36disseminated intravascular coagulation10.0F9, F8
37liver cirrhosis10.0HFE, TNFRSF11B, F9
38psoriatic arthritis10.0TNFSF11, TNFRSF11B, COMP
39synovitis10.0TNFSF11, TNFRSF11B, COMP
40paget disease, juvenile10.0TNFRSF11A, TNFSF11, TNFRSF11B
41polyostotic osteolytic dysplasia, hereditary expansile10.0TNFRSF11A, TNFSF11, TNFRSF11B
42hyperhomocysteinemia10.0F9, F8
43giant cell tumor10.0TNFRSF11B, TNFSF11, TNFRSF11A
44osteoporosis, postmenopausal10.0TNFRSF11A, TNFSF11, TNFRSF11B
45osteopetrosis10.0TNFRSF11A, TNFSF11, TNFRSF11B
46bone cancer10.0TNFRSF11B, TNFSF11, TNFRSF11A
47hypercalcemia10.0TNFRSF11A, TNFSF11, TNFRSF11B
48secondary syphilis10.0TNFRSF11A, TNFSF11, TNFRSF11B
49periodontal disease10.0TNFRSF11A, TNFSF11, TNFRSF11B
50vascular disease10.0TNFRSF11B, TNFSF11, TNFRSF11A

Graphical network of the top 20 diseases related to Hemophilic Arthropathy:



Diseases related to hemophilic arthropathy

Symptoms for Hemophilic Arthropathy

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Drugs & Therapeutics for Hemophilic Arthropathy

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Drug clinical trials:

Search ClinicalTrials for Hemophilic Arthropathy

Search NIH Clinical Center for Hemophilic Arthropathy

Genetic Tests for Hemophilic Arthropathy

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Anatomical Context for Hemophilic Arthropathy

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MalaCards organs/tissues related to Hemophilic Arthropathy:

32
Bone

Animal Models for Hemophilic Arthropathy or affiliated genes

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Publications for Hemophilic Arthropathy

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Articles related to Hemophilic Arthropathy:

(show top 50)    (show all 122)
idTitleAuthorsYear
1
Optimal management of hemophilic arthropathy and hematomas. (25378964)
2014
2
Manual therapy in the treatment of ankle hemophilic arthropathy. A randomized pilot study. (24678758)
2014
3
Viscosupplementation in patients with hemophilic arthropathy. (24453636)
2013
4
Hemophilic arthropathy of shoulder joints: clinical, radiographic, and ultrasonographic characteristics of seventy patients. (23553306)
2013
5
RANK-RANKL-OPG in hemophilic arthropathy: from clinical and imaging diagnosis to histopathology. (22753650)
2012
6
Impact of ankle osteoarthritis on the energetics and mechanics of gait: the case of hemophilic arthropathy. (22381586)
2012
7
Hemophilic arthropathy in patients with von Willebrand disease. (23010260)
2012
8
A long term results of external beam radiation therapy in hemophilic arthropathy of the ankle in children. (21165288)
2010
9
Hemophilic arthropathy. (21623422)
2010
10
Severe hemophilic arthropathy of the elbow and knee. (17552061)
2007
11
Functional disability in children with hemophilic arthropathy. (16485109)
2006
12
HFE mutations in the pathobiology of hemophilic arthropathy. (15802547)
2005
13
Hemophilic arthropathy of the elbow treated by total elbow replacement. A case series. (14996887)
2004
14
Initiation of degenerative joint damage by experimental bleeding combined with loading of the joint: a possible mechanism of hemophilic arthropathy. (15188380)
2004
15
Total knee arthroplasty in hemophilic arthropathy. (14716652)
2004
16
Periarticular aneurysm following total knee replacement in hemophilic arthropathy. A case report. (14668517)
2003
17
Total knee arthroplasty in hemophilic arthropathy. (12639614)
2003
18
Current treatment of hemophilic arthropathy. (11880733)
2002
19
Hemophilic arthropathy: evaluation of clinical and radiological characteristics and disability. (11105618)
2000
20
Hemophilic arthropathy of the elbow. (8543615)
1995
21
Synoviorthesis with colloidal 32P chromic phosphate for the treatment of hemophilic arthropathy. (8150815)
1994
22
Synovectomy of the ankle for hemophilic arthropathy. (8200887)
1994
23
Utility of magnetic resonance imaging for management of hemophilic arthropathy in children. (8355113)
1993
24
Ultrasound in the diagnosis of the early stages of hemophilic arthropathy of the knee. (1632211)
1992
25
MR imaging in hemophilic arthropathy. (1777491)
1991
26
Radiocolloids in the management of hemophilic arthropathy in children and adolescents. (1997228)
1991
27
Surgical management of advanced hemophilic arthropathy. (2408056)
1990
28
Surgical management of advanced hemophilic arthropathy. An overview of 20 years' experience. (2650951)
1989
29
Roentgenographic classifications of hemophilic arthropathy. Comparison of three systems and correlation with clinical parameters. (2918008)
1989
30
Total knee arthroplasty for the treatment of chronic hemophilic arthropathy. (2805504)
1989
31
Intraarticular methylprednisolone therapy in hemophilic arthropathy. (3354555)
1988
32
Hemophilic arthropathy of the temporomandibular joint: review of the literature, a case report, and discussion. (3278263)
1988
33
Synovectomy of the knee for hemophilic arthropathy. (3805065)
1987
34
Hemophilic arthropathy of the upper limb. (3568484)
1987
35
Hemophilic arthropathy resulting in a locked shoulder. (3955945)
1986
36
Total knee arthroplasty in chronic hemophilic arthropathy. (3714579)
1986
37
Synovectomy in hemophilic arthropathy. A retrospective review of 17 cases. (3955942)
1986
38
A long-term study of hemophilic arthropathy of the knee joint on a program of Factor VIII replacement given at time of each hemarthrosis. (3917602)
1985
39
Hemophilic arthropathy complicated by polyarticular septic arthritis. (6421050)
1984
40
Hemophilic arthropathy: a literature review. (6562449)
1983
41
Nonsteroidal anti-inflammatory drugs in the treatment of hemophilic arthropathy. (7072708)
1982
42
Traumatic aneurysm of the descending geniculate artery: a complication of suction drainage in synovectomy for hemophilic arthropathy. (7428228)
1980
43
Hemophilic arthropathy in the elbow. (302402)
1977
44
Hemophilic arthropathy. Current concepts of pathogenesis and management. (849938)
1977
45
Cartilage in hemophilic arthropathy. Ultrastructural and microanalytical studies. (946396)
1976
46
Biochemical and physiological aspects of degenerative joint diseases with special reference to hemophilic arthropathy. (1053873)
1975
47
Hemophilic arthropathy. (4614656)
1974
48
Hemophilic arthropathy. (13775889)
1960
49
Hemophilic arthropathy in dogs. (13836046)
1959
50
Hemophilic arthropathy. (13282597)
1956

Variations for Hemophilic Arthropathy

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Expression for genes affiliated with Hemophilic Arthropathy

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Expression patterns in normal tissues for genes affiliated with Hemophilic Arthropathy

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Pathways for genes affiliated with Hemophilic Arthropathy

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Pathways related to Hemophilic Arthropathy according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5TNFSF11, TNFRSF11A
2
Show member pathways
Apoptosis and survival Anti apoptotic TNFs NF kB IAP pathway60
9.5TNFRSF11A, TNFSF11
39.3TNFSF11, TNFRSF11B
4
Show member pathways
9.2F8, F9
5
Show member pathways
Complement Activation, Classical Pathway37
Complement and Coagulation Cascades37
9.2F8, F9
6
Show member pathways
Apoptosis and survival TNFR1 signaling pathway60
TWEAK Signaling Pathway37
Apoptosis Modulation by HSP7037
HIV-1 Nef- Negative effector of Fas and TNF-alpha37
9.0TNFRSF11B, TNFSF11, TNFRSF11A
7
Show member pathways
9.0TNFRSF11A, TNFSF11, TNFRSF11B
89.0TNFRSF11A, TNFSF11, TNFRSF11B
99.0TNFRSF11B, TNFSF11, TNFRSF11A
109.0TNFRSF11B, TNFSF11, TNFRSF11A
11
Show member pathways
9.0TNFRSF11A, TNFSF11, TNFRSF11B
129.0PTGS2, TNFSF11, TNFRSF11A
139.0TNFRSF11A, TNFSF11, PTGS2
14
Show member pathways
RANKL/RANK Signaling Pathway37
Apoptosis and survival APRIL and BAFF signaling60
8.4PTGS2, TNFRSF11B, TNFSF11, TNFRSF11A
15
Show member pathways
8.4TNFRSF11A, TNFSF11, TNFRSF11B, PTGS2

Compounds for genes affiliated with Hemophilic Arthropathy

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Compounds related to Hemophilic Arthropathy according to GeneCards/GeneDecks:

(show top 50)    (show all 102)
idCompoundScoreTop Affiliating Genes
1hcc-1449.7TNFSF11, TNFRSF11B
2tributylphosphate449.6F9, F8
3rfviii449.6F9, F8
4kaolin449.5F9, F8
5teriparatide44 1110.5TNFRSF11B, TNFSF11
6tween 80449.5F8, F9
7ibandronate44 1110.4TNFRSF11B, TNFSF11
8p003449.4COMP, HFE, TNFRSF11B
9deoxypyridinoline449.4COMP, TNFSF11, TNFRSF11B
10denosumab44 1110.4TNFSF11, TNFRSF11A, TNFRSF11B
11leflunomide44 50 1111.4PTGS2, TNFSF11, COMP
12polyethylene449.4TNFRSF11A, TNFSF11, TNFRSF11B
13infliximab44 50 1111.4COMP, TNFRSF11B, TNFSF11
14raloxifene44 50 28 1112.4TNFRSF11A, TNFSF11, TNFRSF11B
15procollagen449.3TNFRSF11B, COMP, TNFSF11
16hydroxyapatite449.3TNFRSF11A, TNFSF11, TNFRSF11B
17gp 130449.3TNFRSF11B, TNFSF11, TNFRSF11A
18risedronate44 50 28 61 1113.2TNFSF11, TNFRSF11B, PTGS2
19clodronate44 50 1111.2TNFRSF11B, TNFSF11, PTGS2
20ns 39844 6110.2TNFSF11, TNFRSF11B, PTGS2
211,25 dihydroxy vitamin d3449.2TNFRSF11B, TNFRSF11A, TNFSF11
22laccer449.2TNFRSF11A, TNFSF11
23celecoxib44 61 28 50 24 1114.2TNFRSF11B, TNFSF11, PTGS2
24desmopressin44 61 28 1112.1F8, F9, PTGS2
25acetaminophen44 2 50 24 1113.1F9, PTGS2, F8
26urea44 24 1111.0TNFRSF11B, TNFSF11, F9
27homocysteine44 249.9F8, TNFRSF11B, F9
28etanercept44 50 1110.9TNFSF11, PTGS2, COMP, TNFRSF11B
29latex448.9F8, TNFSF11, F9
30prostaglandin448.9TNFRSF11A, TNFRSF11B, PTGS2, TNFSF11
31agarose448.9COMP, F8, HFE
32thromboxane a244 249.9TNFSF11, PTGS2, F8
33prednisolone44 28 1110.8COMP, F8, TNFRSF11B, F9
34pge2448.7TNFRSF11A, PTGS2, TNFSF11, TNFRSF11B
35tgf beta1448.7COMP, F8, TNFRSF11B
36gold448.7F8, HFE, TNFRSF11B
37iron44 249.5HFE, F8, PTGS2, TNFRSF11B
38cyclosporin a44 28 6110.4F9, TNFRSF11B, TNFSF11, F8
39aspartate448.3TNFRSF11B, F8, COMP, HFE, F9
40glucose448.3HFE, COMP, F9, F8, TNFRSF11B
41heparin44 28 24 1111.3TNFRSF11B, TNFSF11, F8, F9
42creatinine448.2COMP, F8, F9, TNFRSF11B, TNFSF11
43vegf448.0F8, TNFRSF11B, PTGS2, TNFRSF11A, TNFSF11
44nitric oxide44 24 1110.0F8, PTGS2, TNFRSF11A, TNFSF11, TNFRSF11B
45cysteine447.7HFE, F9, TNFSF11, TNFRSF11B, F8, COMP
46calcium44 50 24 1110.7COMP, F8, TNFRSF11B, TNFSF11, F9, TNFRSF11A
47tyrosine447.7F9, F8, HFE, TNFSF11, TNFRSF11B, TNFRSF11A
48dexamethasone44 50 28 1110.6F8, TNFSF11, PTGS2, TNFRSF11B, TNFRSF11A, F9
49lipid447.4HFE, COMP, TNFRSF11B, TNFSF11, TNFRSF11A, F9
50estrogen447.2F8, PTGS2, TNFRSF11B, TNFSF11, TNFRSF11A, F9

GO Terms for genes affiliated with Hemophilic Arthropathy

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Cellular components related to Hemophilic Arthropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.2COMP, F8, TNFRSF11B, TNFSF11
2extracellular regionGO:0055767.5COMP, F8, TNFRSF11B, TNFSF11, F9

Biological processes related to Hemophilic Arthropathy according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of fever generation by positive regulation of prostaglandin secretionGO:0718129.7TNFSF11, TNFRSF11A
2positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signalingGO:0718489.7TNFRSF11A, TNFSF11
3TNFSF11-mediated signaling pathwayGO:0718479.7TNFRSF11A, TNFSF11
4mammary gland alveolus developmentGO:0607499.6TNFSF11, TNFRSF11A
5monocyte chemotaxisGO:0025489.6TNFSF11, TNFRSF11A
6osteoclast differentiationGO:0303169.5TNFSF11, TNFRSF11A
7ossificationGO:0015039.5TNFSF11, TNFRSF11A
8response to tumor necrosis factorGO:0346129.5PTGS2, TNFRSF11A
9blood coagulation, intrinsic pathwayGO:0075979.3F9, F8
10tumor necrosis factor-mediated signaling pathwayGO:0332099.2TNFSF11, TNFRSF11A

Products for genes affiliated with Hemophilic Arthropathy

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Sources for Hemophilic Arthropathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet