MCID: HMR039
MIFTS: 57

Hemorrhage, Intracerebral

Categories: Genetic diseases, Neuronal diseases

Aliases & Classifications for Hemorrhage, Intracerebral

MalaCards integrated aliases for Hemorrhage, Intracerebral:

Name: Hemorrhage, Intracerebral 53
Hemorrhage, Intracerebral, Susceptibility to 53 28 13
Hemorrhagic Stroke 71 51 40
Ich 53 72 71
Intracerebral Hemorrhage 71 51
Stroke, Hemorrhagic, Susceptibility to 53
Stroke, Hemorrhagic 53
Cerebral Hemorrhage 41
Brain Hemorrhage 69

Classifications:



External Ids:

OMIM 53 614519
MeSH 41 D002543
UMLS 69 C0553692

Summaries for Hemorrhage, Intracerebral

MedlinePlus : 40 A stroke is a medical emergency. There are two types - ischemic and hemorrhagic. Hemorrhagic stroke is the less common type. It happens when a blood vessel breaks and bleeds into the brain. Within minutes, brain cells begin to die. Causes include a bleeding aneurysm, an arteriovenous malformation (AVM), or an artery wall that breaks open. Symptoms of stroke are Sudden numbness or weakness of the face, arm or leg (especially on one side of the body) Sudden confusion, trouble speaking or understanding speech Sudden trouble seeing in one or both eyes Sudden trouble walking, dizziness, loss of balance or coordination Sudden severe headache with no known cause It is important to treat strokes as quickly as possible. With a hemorrhagic stroke, the first steps are to find the cause of bleeding in the brain and then control it. Surgery may be needed. Post-stroke rehabilitation can help people overcome disabilities caused by stroke damage. National Institute of Neurological Disorders and Stroke

MalaCards based summary : Hemorrhage, Intracerebral, also known as hemorrhage, intracerebral, susceptibility to, is related to cerebral hemorrhage and cerebrovascular disease, and has symptoms including sleeplessness, vertigo/dizziness and chronic pain. An important gene associated with Hemorrhage, Intracerebral is COL4A1 (Collagen Type IV Alpha 1 Chain), and among its related pathways/superpathways are Binding and Uptake of Ligands by Scavenger Receptors and Apoptosis-related network due to altered Notch3 in ovarian cancer. The drugs Aspirin and Cilostazol have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and cortex, and related phenotypes are cardiovascular system and growth/size/body region

UniProtKB/Swiss-Prot : 71 Intracerebral hemorrhage: A pathological condition characterized by bleeding into one or both cerebral hemispheres including the basal ganglia and the cerebral cortex. It is often associated with hypertension and craniocerebral trauma. Intracerebral bleeding is a common cause of stroke.

Wikipedia : 72 Intracerebral hemorrhage (ICH), also known as cerebral bleed, is a type of intracranial bleed that... more...

Description from OMIM: 614519

Related Diseases for Hemorrhage, Intracerebral

Diseases related to Hemorrhage, Intracerebral via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Related Disease Score Top Affiliating Genes
1 cerebral hemorrhage 33.5 APP CST3
2 cerebrovascular disease 30.7 ACE APOE APP COL4A1 PLAT
3 cerebral amyloid angiopathy, cst3-related 29.0 APOE APP CST3
4 stroke, ischemic 28.7 ACE APOE HMGCR PLAT
5 cerebral amyloid angiopathy, app-related 12.1
6 moyamoya disease 1 11.2
7 hyperaldosteronism, familial, type i 11.2
8 cerebral arteriosclerosis 10.9
9 familial porencephaly 10.4 COL4A1 COL4A2
10 porencephaly 10.4 COL4A1 COL4A2
11 corneal dystrophy, posterior polymorphous, 3 10.4 COL4A1 COL4A2
12 anterolateral myocardial infarction 10.3 ACE PLAT
13 angina pectoris 10.3 ACE PLAT
14 intermediate coronary syndrome 10.2 ACE PLAT
15 marek disease 10.2 ACE HMGCR
16 systolic heart failure 10.2 ACE CST3
17 hepatorenal syndrome 10.2 ACE CST3
18 hemiplegia 10.2 COL4A1 COL4A2
19 moderate and severe traumatic brain injury 10.2 ACE APOE
20 generalized atherosclerosis 10.2 ACE APOE
21 cerebral atherosclerosis 10.1 ACE APOE
22 intracranial vasospasm 10.1 APOE PLAT
23 peripheral artery disease 10.1 ACE CST3
24 ischemic heart disease 10.1 ACE APOE
25 aortic atherosclerosis 10.1 ACE APOE
26 senile plaque formation 10.1 APOE APP
27 defective apolipoprotein b-100 10.0 APOE HMGCR
28 gait apraxia 10.0 APOE APP
29 familial idiopathic basal ganglia calcification 10.0 APOE APP
30 homozygous familial hypercholesterolemia 10.0 APOE HMGCR
31 binswanger's disease 10.0 APOE APP
32 xanthomatosis 9.9 APOE HMGCR
33 alzheimer disease 2 9.9 APOE APP
34 coronary stenosis 9.9 ACE APOE
35 hyperlipoproteinemia, type iii 9.9 APOE HMGCR
36 hyperlipidemia, familial combined 9.9 APOE HMGCR
37 ischemia 9.9 ACE APP PLAT
38 chronic kidney failure 9.9 ACE CST3 HMGCR
39 smith-lemli-opitz syndrome 9.9 APOE HMGCR
40 hypertension, essential 9.9 ACE CST3 PLAT
41 aphasia 9.9 APOE APP
42 arteries, anomalies of 9.9 ACE APOE PLAT
43 aortic aneurysm, familial abdominal, 1 9.8 ACE APOE CST3
44 coronary heart disease 1 9.8 ACE APOE HMGCR
45 lipid metabolism disorder 9.8 ACE APOE HMGCR
46 atherosclerosis susceptibility 9.8 ACE APOE HMGCR
47 carotid artery disease 9.8 ACE APOE
48 arteriosclerosis 9.8 ACE APOE HMGCR
49 pick disease of brain 9.7 APOE APP
50 kidney disease 9.7 ACE APOE CST3

Graphical network of the top 20 diseases related to Hemorrhage, Intracerebral:



Diseases related to Hemorrhage, Intracerebral

Symptoms & Phenotypes for Hemorrhage, Intracerebral

Clinical features from OMIM:

614519

UMLS symptoms related to Hemorrhage, Intracerebral:


sleeplessness, vertigo/dizziness, chronic pain, tremor, syncope, seizures, sciatica, pain, headache, edema, chest pain, back pain, angina pectoris

MGI Mouse Phenotypes related to Hemorrhage, Intracerebral:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.06 ACE APOE APP CCM2 COL4A1 COL4A2
2 growth/size/body region MP:0005378 9.98 HMGCR PLAT ACE APOE APP CCM2
3 homeostasis/metabolism MP:0005376 9.97 ACE APOE APP CCM2 COL4A1 CST3
4 mortality/aging MP:0010768 9.97 HMGCR PLAT ACE APOE APP CCM2
5 hematopoietic system MP:0005397 9.95 ACE APOE APP CCM2 COL4A1 COL4A2
6 muscle MP:0005369 9.73 APOE APP CCM2 COL4A1 CST3 PLAT
7 nervous system MP:0003631 9.7 APOE APP CCM2 COL4A1 COL4A2 CST3
8 reproductive system MP:0005389 9.43 PLAT ACE APOE APP COL4A1 CST3
9 vision/eye MP:0005391 9.02 APOE CCM2 COL4A1 COL4A2 PLAT

Drugs & Therapeutics for Hemorrhage, Intracerebral

Drugs for Hemorrhage, Intracerebral (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 304)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aspirin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 50-78-2 2244
2
Cilostazol Approved, Investigational Phase 4,Phase 3 73963-72-1 2754
3
Probucol Approved, Investigational Phase 4 23288-49-5 4912
4
Heparin Approved, Investigational Phase 4,Phase 3 9005-49-6 46507594 772
5
Nicardipine Approved, Investigational Phase 4,Phase 3,Phase 1 55985-32-5 4474
6
Clevidipine Approved, Investigational Phase 4,Phase 3,Phase 2 167221-71-8
7
Dalteparin Approved Phase 4,Phase 2 9005-49-6
8 Nadroparin Approved, Investigational Phase 4 9041-08-1
9
Warfarin Approved Phase 4,Phase 3 81-81-2 54678486 6691
10
Clopidogrel Approved Phase 4,Phase 3,Phase 2 120202-66-6, 113665-84-2 60606
11
Ticlopidine Approved Phase 4,Phase 3 55142-85-3 5472
12
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 1994-09-7, 94-09-7 2337
13
Mannitol Approved, Investigational Phase 4 69-65-8 6251 453
14
Valproic Acid Approved, Investigational Phase 4 99-66-1 3121
15
Thrombin Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2
16
Amlodipine Approved Phase 4 88150-42-9 2162
17
Angiotensin II Approved, Investigational Phase 4 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
18
Olmesartan Approved, Investigational Phase 4 144689-24-7, 144689-63-4 158781 130881
19
Ethanol Approved Phase 4,Phase 1,Phase 2 64-17-5 702
20
Pitavastatin Approved Phase 4 147511-69-1, 147526-32-7 5282452 6366718
21
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
22
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
23
Indapamide Approved Phase 4 26807-65-8 3702
24
Telmisartan Approved, Investigational Phase 4 144701-48-4 65999
25
Etomidate Approved Phase 4 33125-97-2 667484 36339
26
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
27
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
28
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
29
Succinylcholine Approved Phase 4 306-40-1 5314
30
Desflurane Approved Phase 4 57041-67-5 42113
31
Dexmedetomidine Approved, Vet_approved Phase 4 76631-46-4, 113775-47-6 5311068 56032 68602
32
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
33
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
34
Menadione Approved, Nutraceutical Phase 4,Phase 3,Early Phase 1 58-27-5 4055
35
Phytonadione Approved, Investigational, Nutraceutical Phase 4,Phase 3,Early Phase 1 84-80-0 5284607 4812
36 tannic acid Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
37
Ginseng Approved, Investigational, Nutraceutical Phase 4 50647-08-0
38
Caffeine Approved, Nutraceutical Phase 4,Phase 1,Phase 2 58-08-2 2519
39
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
40
Butyric Acid Experimental, Investigational Phase 4,Phase 2 107-92-6 264
41 Urapidil Investigational Phase 4,Phase 3 34661-75-1
42 Analgesics Phase 4,Phase 2,Phase 3,Phase 1
43 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 3,Phase 1
44 Anti-Asthmatic Agents Phase 4,Phase 3,Phase 2
45 Anticholesteremic Agents Phase 4,Phase 2
46 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Phase 1
47 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 2,Phase 3,Phase 1
48 Antimetabolites Phase 4,Phase 2
49 Antioxidants Phase 4,Phase 2,Phase 3
50 Antipyretics Phase 4,Phase 2,Phase 3,Phase 1

Interventional clinical trials:

(show top 50) (show all 347)

# Name Status NCT ID Phase Drugs
1 Clinical Re-evaluation of Removing Blood Stasis Therapy in Treating Acute Cerebral Hemorrhage Safety and Efficacy Unknown status NCT01918722 Phase 4 ICH-1(herbal medicine with Hirudo, Tabanus);placebo;ICH-2(herbal medicine without Hirudo, Tabanus)
2 PreventIon of CArdiovascular Events in iSchemic Stroke Patients With High Risk of Cerebral HemOrrhage Unknown status NCT01013532 Phase 4 Cilostazol;Probucol;Aspirin;placebo of cilostazol;placebo of aspirin
3 Prevention of Venous Thromboembolism in Patients With Acute Primary Intracerebral Hemorrhage Unknown status NCT00699465 Phase 4 enoxaparin;enoxaparin placebo
4 PreventIon of IMT Progression in iSchemic Stroke Patients With High Risk of Cerebral HemOrrhage-IMT Study Unknown status NCT02483169 Phase 4 cilostazol;Probucol;Aspirin;placebo of cilostazol;Placebo of aspirin
5 IV Double and Triple Concentrated Nicardipine for Stroke and ICH Unknown status NCT00325793 Phase 4 Nicardipine
6 ASCEND: A Study of Cardiovascular Events iN Diabetes Unknown status NCT00135226 Phase 4 aspirin;Omega-3-acid Ethyl Esters;Placebo Aspirin;Placebo omega-3-Ethyl Esters
7 Comparison of Staged Angioplasty and Routine Single-stage Stenting (CAS) in the Treatment of Carotid Artery Stenosis Unknown status NCT02224209 Phase 4
8 The Efficacy and Safety of Cleviprex in Ventriculostomy Patients Requiring IV Antihypertensive Therapy Unknown status NCT01042574 Phase 4 Clevidipine butyrate
9 Low Dose Rt-PA for Acute Normotensive Pulmonary Embolism With RVD Unknown status NCT01531829 Phase 4 Recombinant tissue plasminogen activator (rt-PA);Low Molecular Weight Heparin
10 The Effectiveness and Safety of Butylphthalide Soft Capsules in Secondary Prevention of Ischemic Stroke Trial Unknown status NCT00724724 Phase 4 Butylphthalide Soft Capsules;Aspirin
11 Clinical Study on the Treatment of Hypertensive Intracerebral Hemorrhage With Panax Notoginseng Saponin Completed NCT02999048 Phase 4 Panax Notoginseng Saponins
12 Seizures Post Intracerebral Hemorrhage Completed NCT01115959 Phase 4 valproic acid;placebo bid
13 International Normalized Ratio (INR) Normalization in Coumadin Associated Intracerebral Haemorrhage Completed NCT00928915 Phase 4 Prothrombin complex concentrate (PCC); fresh frozen plasma (FFP)
14 COMbination of Clopidogrel and Aspirin for Prevention of Early REcurrence in Acute Atherothrombotic Stroke Completed NCT00814268 Phase 4 Clopidogrel;Clopidogrel placebo;Aspirin
15 Temperature Control in Central Fever in the Neuro-ICU Completed NCT00751634 Phase 4
16 MRI and Neurodevelopment in Preterm Infants Following Administration of High-Dose Caffeine Completed NCT00809055 Phase 4 Caffeine citrate
17 Comparative Infection Rates for the Codman BACTISEAL TM External Ventricular Drainage (EVD) System Completed NCT00197392 Phase 4
18 Imaging Guided Patient Selection for Interventional Revascularization Therapy Completed NCT00963989 Phase 4
19 OlmeSartan and Calcium Antagonists Randomized (OSCAR) Study Completed NCT00134160 Phase 4 Olmesartan medoxomil;Calcium channel blockers (amlodipine, azelnidipine)
20 Japan Prevention Trial of Diabetes by Pitavastatin in Patients With Impaired Glucose Tolerance (J-PREDICT) Completed NCT00301392 Phase 4 Life style interventions plus concomitant use of pitavastatin.
21 Clevidipine (Cleviprex®) Compared With Urapidil (Ebrantil®) Recruiting NCT03300479 Phase 4 Clevidipine;Urapidil
22 Triple Therapy Prevention of Recurrent Intracerebral Disease EveNts Trial Recruiting NCT02699645 Phase 4 telmisartan 20mg, amlodipine 2.5mg, and indapamide 1.25mg;Placebo
23 Shuxuetong for Prevention of Recurrence in Acute Cerebrovascular Events With Embolism Recruiting NCT03090113 Phase 4 Shuxuetong Injection;Placebo Injection
24 Study of Antithrombotic Treatment After Intracerebral Haemorrhage Not yet recruiting NCT03186729 Phase 4 Antithrombotic Agent
25 Clinical Evaluation of Removing Blood Stasis Therapy in Treating Acute Cerebral Hemorrhage Safety and Efficacy Not yet recruiting NCT03354026 Phase 4 AICH-PXZY;AICH-without PXZY;AICH-placebo
26 SEdation Versus General Anesthesia for Endovascular Therapy in Acute Ischemic Stroke Not yet recruiting NCT03263117 Phase 4 Sedation;General Anesthesia (GA)
27 Antenatal Rescue Course of Glucocorticoids in Threatened Premature Birth Terminated NCT00295464 Phase 4 Betamethasone sodium phos (drug)
28 Effectiveness and Safety of Rhubarb for the Treatment of Patients Who Have Suffered From Cerebral Hemorrhage Unknown status NCT00815737 Phase 2, Phase 3 rhubarb;Placebo
29 Pilot Study of Hypothermia for Intracerebral Hemorrhage in Croatia Unknown status NCT01221142 Phase 3
30 Edoxaban for TIA and Acute Minor Stroke Unknown status NCT02221102 Phase 2, Phase 3 Aspirin;edoxaban;placebo
31 Treatment of Rivaroxaban Versus Aspirin for Non-disabling Cerebrovascular Events Unknown status NCT01923818 Phase 2, Phase 3 rivaroxaban;Aspirin;placebo
32 Management of Hypotension In the Preterm Infant Unknown status NCT01482559 Phase 3 Dopamine hydrochloride;Dextrose 5%
33 Cilostazol Stroke Prevention Study for Antiplatelet Combination Unknown status NCT01995370 Phase 3 aspirin;clopidogrel;cilostazol
34 Recombinant Factor VIIa in Acute Intracerebral Haemorrhage Completed NCT00127283 Phase 3 eptacog alfa (activated)
35 Clevidipine in the Treatment of Patients With Acute Hypertension and Intracerebral Hemorrhage (ACCELERATE) Completed NCT00666328 Phase 3 clevidipine
36 A Randomised Controlled Trial of Lumbar Drainage to Treat Communicating Hydrocephalus After Severe Intraventricular Hemorrhage Completed NCT01041950 Phase 2, Phase 3
37 Warfarin Versus Aspirin in Reduced Cardiac Ejection Fraction (WARCEF) Trial Completed NCT00041938 Phase 3 aspirin;Warfarin
38 Clot Lysis: Evaluating Accelerated Resolution of Intraventricular Hemorrhage Phase III Completed NCT00784134 Phase 3 Alteplase
39 Sarpogrelate-Aspirin Comparative Clinical Study for Efficacy and Safety in Secondary Prevention of Cerebral Infarction (S-ACCESS) Completed NCT00129805 Phase 3 MCI-9042;Aspirin
40 Improving DEtection of Atrial fibriLlation in Primary Care With the MyDiagnostick Completed NCT02270151 Phase 3
41 Secondary Prevention of Small Subcortical Strokes Trial Completed NCT00059306 Phase 3 aspirin;clopidogrel
42 Study of Tenecteplase Versus Alteplase for Thrombolysis (Clot Dissolving) in Acute Ischemic Stroke Completed NCT01949948 Phase 3 Tenecteplase;Alteplase
43 Randomized Evaluation of Long Term Anticoagulant Therapy (RE-LY) With Dabigatran Etexilate Completed NCT00262600 Phase 3 warfarin;Dabigatran dose 1;Dabigatran dose 2
44 Indomethacin Germinal Matrix Hemorrhage/Intraventricular Hemorrhage (GMH/IVH) Prevention Trial Completed NCT00033917 Phase 3 indomethacin;placebo
45 Antenatal Phenobarbital to Prevent Neonatal Intracranial Hemorrhage Completed NCT00009620 Phase 3 Phenobarbital;Saline
46 Patent Foramen Ovale Closure or Anticoagulants Versus Antiplatelet Therapy to Prevent Stroke Recurrence Completed NCT00562289 Phase 3 aspirin;Antivitamins K or rivaroxaban or dabigatran or apixaban
47 Beneficial Effects of Antenatal Magnesium Sulfate (BEAM Trial) Completed NCT00014989 Phase 3 magnesium sulfate
48 Treatment of Intracerebral Hemorrhage in Patients on Non-vitamin K Antagonist Recruiting NCT02866838 Phase 2, Phase 3 Tranexamic acid;Saline 0.9%
49 REstart or STop Antithrombotic Randomised Trial in France Recruiting NCT02966119 Phase 3 Clopidogrel or Aspirin and/or Dypyridamole
50 Contrast Enhanced Sonothrombolysis and Sonolysis in Stroke - a Swedish Study (CE-5S) Recruiting NCT03290053 Phase 3 SonoVue;Sodium chloride

Search NIH Clinical Center for Hemorrhage, Intracerebral

Cochrane evidence based reviews: cerebral hemorrhage

Genetic Tests for Hemorrhage, Intracerebral

Genetic tests related to Hemorrhage, Intracerebral:

# Genetic test Affiliating Genes
1 Hemorrhage, Intracerebral, Susceptibility to 28 ACE COL4A1 COL4A2

Anatomical Context for Hemorrhage, Intracerebral

MalaCards organs/tissues related to Hemorrhage, Intracerebral:

38
Brain, Eye, Cortex, Lung, Bone, Heart, Testes

Publications for Hemorrhage, Intracerebral

Articles related to Hemorrhage, Intracerebral:

(show top 50) (show all 94)
# Title Authors Year
1
Relationship Between Bacteremia and Hemorrhagic Stroke in Patients With Continuous-Flow Left Ventricular Assist Device. ( 28943532 )
2017
2
Pharmacological targeting of secondary brain damage following ischemic or hemorrhagic stroke, traumatic brain injury, and bacterial meningitis - a systematic review and meta-analysis. ( 29212462 )
2017
3
Influenza vaccination reduces hemorrhagic stroke risk in patients with atrial fibrillation: A population-based cohort study. ( 28089151 )
2016
4
Association of APOE (E2, E3 and E4) gene variants and lipid levels in ischemic stroke, its subtypes and hemorrhagic stroke in a South Indian population. ( 27329241 )
2016
5
Churg-Strauss syndrome in a pediatric patient presenting with recurrent hemorrhagic stroke and mitral regurgitation due to a prolapsed mitral valve. ( 27381148 )
2016
6
Impact of systolic blood pressure on hemorrhagic stroke in patients with coronary artery disease during anti-platelet therapy: The Japanese Coronary Artery Disease (JCAD) study. ( 27648978 )
2016
7
Polymorphisms in three genes are associated with hemorrhagic stroke. ( 26664786 )
2015
8
Imaging manifestations and diagnosis of a case of adult cerebral paragonimiasis with the initial symptom of hemorrhagic stroke. ( 26309598 )
2015
9
Association of ACE gene I/D polymorphism and ACE levels with hemorrhagic stroke: comparison with ischemic stroke. ( 25015258 )
2015
10
The first documented case of hemorrhagic stroke caused by Group B streptococcal meningitis. ( 26793476 )
2015
11
Combined direct and indirect revascularization is associated with low rates of recurrent ischemic and hemorrhagic stroke in adult moyamoya disease. ( 25784009 )
2015
12
CRP gene (1059G>C) polymorphism and its plasma levels in ischemic stroke and hemorrhagic stroke in a south Indian population. ( 24771073 )
2014
13
Visual disorders, the prosopometamorphopsia and prosopagnosia type in the early days after the onset of brain hemorrhagic stroke - a case report. ( 24592926 )
2014
14
Migraine and risk of hemorrhagic stroke: a study based on data from general practice. ( 25387444 )
2014
15
Hemorrhagic stroke and cerebral paragonimiasis. ( 25270625 )
2014
16
Impact of proteinuria and glomerular filtration rate on risk of ischaemic and intracerebral hemorrhagic stroke: a result from the Kailuan study. ( 25346321 )
2014
17
Terson syndrome in subarachnoid hemorrhage, intracerebral hemorrhage, and traumatic brain injury. ( 25173620 )
2014
18
Association of -1382A>G CCL11 gene variant with ischemic stroke, its subtypes and hemorrhagic stroke in a South Indian population. ( 25237944 )
2014
19
Functional electrical stimulation to ankle dorsiflexor and plantarflexor using single foot switch in patients with hemiplegia from hemorrhagic stroke. ( 25024953 )
2014
20
E-selectin gene (S128R) polymorphism in hemorrhagic stroke: comparison with ischemic stroke. ( 25168603 )
2014
21
Progressive manifestations of reversible cerebral vasoconstriction syndrome presenting with subarachnoid hemorrhage, intracerebral hemorrhage, and cerebral infarction. ( 25535520 )
2014
22
Lipoprotein-associated phospholipase A2 during the hyperacute stage of ischemic and hemorrhagic strokes. ( 24513482 )
2014
23
Association of genetic polymorphisms at beta-adrenergic receptor with risk of intracerebral hemorrhagic stroke in North Indian population: a case control study. ( 24823730 )
2014
24
Association of the C677T polymorphism in the MTHFR gene with hemorrhagic stroke: a meta-analysis. ( 23428159 )
2013
25
Mycotic brain aneurysm and cerebral hemorrhagic stroke: a pediatric case report. ( 23686512 )
2013
26
Microscopic Polyangiitis Presenting With Hemorrhagic Stroke. ( 23690295 )
2013
27
Quantitative assessment of the association between MTHFR C677T polymorphism and hemorrhagic stroke risk. ( 23184002 )
2013
28
Malignant paraganglioma presenting with hemorrhagic stroke in a child. ( 24276837 )
2013
29
Prevention of venous thromboembolism in patients with hemorrhagic stroke. ( 23611851 )
2013
30
Fatal hemorrhagic stroke in a Caucasian girl with moyamoya disease. ( 23549955 )
2013
31
Migraine and hemorrhagic stroke: a meta-analysis. ( 24085027 )
2013
32
Association of deep venous thrombosis with calf vein diameter in acute hemorrhagic stroke. ( 22424847 )
2013
33
Factor XIII-A subunit Val34Leu polymorphism in fatal hemorrhagic stroke. ( 22909010 )
2013
34
Anaplastic astrocytoma masquerading as hemorrhagic stroke. ( 23510543 )
2013
35
Endovascular cooling and endothelial activation in hemorrhagic stroke patients. ( 21380565 )
2012
36
BDNF -270 C>T polymorphisms might be associated with stroke type and BDNF -196 G>A corresponds to early neurological deficit in hemorrhagic stroke. ( 22633192 )
2012
37
MMP-2/MMP-9 plasma level and brain expression in cerebral amyloid angiopathy-associated hemorrhagic stroke. ( 21707819 )
2012
38
Plasma I^-amyloid levels in cerebral amyloid angiopathy-associated hemorrhagic stroke. ( 22261638 )
2012
39
Hemorrhage and risk of further hemorrhagic strokes following cerebral revascularization in Moyamoya disease: A review of the literature. ( 22937473 )
2012
40
VAP-1/SSAO plasma activity and brain expression in human hemorrhagic stroke. ( 22133888 )
2012
41
COL4A2 mutations impair COL4A1 and COL4A2 secretion and cause hemorrhagic stroke. ( 22209247 )
2012
42
A single-center study of hemorrhagic stroke caused by cerebrovascular disease during pregnancy and puerperium in China. ( 21334622 )
2011
43
Migraine with aura--indication of an increased risk of hemorrhagic stroke in women (Women's Health Study) and increased risk of overall death in an Icelandic population (Reykjavik Study). ( 21252164 )
2011
44
A study of ACE and ADD1 polymorphism in ischemic and hemorrhagic stroke. ( 21194526 )
2011
45
NC1900, an arginine vasopressin analogue, fails to reduce brain edema and improve neurobehavioral deficits in an intracerebral hemorrhagic stroke mice model. ( 21725748 )
2011
46
Evaluation of MTHFR C677T polymorphism in ischemic and hemorrhagic stroke patients. A case-control study in a Northern Indian population. ( 21406306 )
2011
47
Prospective study of first stroke in relation to plasma homocysteine and MTHFR 677C>T and 1298A>C genotypes and haplotypes - evidence for an association with hemorrhagic stroke. ( 21631392 )
2011
48
Association of genetic variants with hemorrhagic stroke in Japanese individuals. ( 20198315 )
2010
49
Delayed-onset oromandibular dystonia after a cerebellar hemorrhagic stroke. ( 20692865 )
2010
50
Comparison of urodynamics between ischemic and hemorrhagic stroke patients; can we suggest the category of urinary dysfunction in patients with cerebrovascular accident according to type of stroke? ( 19229954 )
2010

Variations for Hemorrhage, Intracerebral

UniProtKB/Swiss-Prot genetic disease variations for Hemorrhage, Intracerebral:

71
# Symbol AA change Variation ID SNP ID
1 COL4A1 p.Pro352Leu VAR_073810
2 COL4A1 p.Arg538Gly VAR_073811

ClinVar genetic disease variations for Hemorrhage, Intracerebral:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 ACE NM_000789.3(ACE): c.2306-117_2306-116insAF118569.1: g.14094_14382 insertion risk factor rs4340 GRCh37 Chromosome 17, 61565892: 61565893
2 COL4A2 NM_001846.3(COL4A2): c.3368A> G (p.Glu1123Gly) single nucleotide variant risk factor rs117412802 GRCh37 Chromosome 13, 111143601: 111143601
3 COL4A2 NM_001846.3(COL4A2): c.3448C> A (p.Gln1150Lys) single nucleotide variant risk factor rs62621875 GRCh37 Chromosome 13, 111143681: 111143681
4 COL4A2 NM_001846.3(COL4A2): c.5068G> A (p.Ala1690Thr) single nucleotide variant risk factor rs201105747 GRCh37 Chromosome 13, 111164467: 111164467
5 COL4A1 NM_001845.5(COL4A1): c.1055C> T (p.Pro352Leu) single nucleotide variant risk factor rs200786329 GRCh37 Chromosome 13, 110853814: 110853814
6 COL4A1 NM_001845.5(COL4A1): c.1612C> G (p.Arg538Gly) single nucleotide variant risk factor rs397514624 GRCh37 Chromosome 13, 110839601: 110839601

Expression for Hemorrhage, Intracerebral

Search GEO for disease gene expression data for Hemorrhage, Intracerebral.

Pathways for Hemorrhage, Intracerebral

GO Terms for Hemorrhage, Intracerebral

Cellular components related to Hemorrhage, Intracerebral according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.88 ACE APOE APP COL4A2 CST3 PLAT
2 extracellular region GO:0005576 9.8 ACE APOE APP COL4A1 COL4A2 CST3
3 extracellular matrix GO:0031012 9.67 APOE COL4A1 COL4A2 PLAT
4 basement membrane GO:0005604 9.5 COL4A1 COL4A2 CST3
5 extracellular space GO:0005615 9.5 ACE APOE APP COL4A1 COL4A2 CST3
6 collagen type IV trimer GO:0005587 9.16 COL4A1 COL4A2
7 endoplasmic reticulum lumen GO:0005788 9.02 APOE APP COL4A1 COL4A2 CST3

Biological processes related to Hemorrhage, Intracerebral according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.61 APOE APP CST3
2 extracellular matrix organization GO:0030198 9.58 APP COL4A1 COL4A2
3 response to oxidative stress GO:0006979 9.5 APOE APP CST3
4 visual learning GO:0008542 9.48 APP HMGCR
5 negative regulation of MAP kinase activity GO:0043407 9.46 APOE HMGCR
6 negative regulation of proteolysis GO:0045861 9.37 CST3 PLAT
7 cholesterol metabolic process GO:0008203 9.33 APOE APP HMGCR
8 collagen-activated tyrosine kinase receptor signaling pathway GO:0038063 9.26 COL4A1 COL4A2
9 negative regulation of long-term synaptic potentiation GO:1900272 8.96 APOE APP
10 positive regulation of amyloid fibril formation GO:1905908 8.62 APOE APP

Sources for Hemorrhage, Intracerebral

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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