MCID: HMR039
MIFTS: 35

Hemorrhage, Intracerebral malady

Genetic diseases (common), Neuronal diseases categories

Aliases & Classifications for Hemorrhage, Intracerebral

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Sources:
45OMIM, 60UMLS, 10diseasecard, 43Novoseek, 22GTR
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Hemorrhage, Intracerebral, Aliases & Descriptions:

Name: Hemorrhage, Intracerebral 45
Intracerebral Hemorrhage 43 22
Hemorrhage, Intracerebral, Susceptibility to 10
Cerebral Hemorrhage 60
 
Stroke, Hemorrhagic 45
Hemorrhagic Stroke 43
Brain Hemorrhage 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)
Anatomical: Neuronal diseases


External Ids:

OMIM45 614519

Summaries for Hemorrhage, Intracerebral

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MalaCards based summary: Hemorrhage, Intracerebral, also known as intracerebral hemorrhage, is related to porencephaly and brain edema. An important gene associated with Hemorrhage, Intracerebral is COL4A1 (collagen, type IV, alpha 1), and among its related pathways are Pathways in cancer and Focal adhesion. The compound arresten have been mentioned in the context of this disorder. Affiliated tissues include brain, and related mouse phenotypes are other and cardiovascular system.

Description from OMIM:45 614519

Related Diseases for Hemorrhage, Intracerebral

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Graphical network of the top 20 diseases related to Hemorrhage, Intracerebral:



Diseases related to hemorrhage, intracerebral

Symptoms for Hemorrhage, Intracerebral

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Clinical features from OMIM:

614519

Drugs & Therapeutics for Hemorrhage, Intracerebral

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Drug clinical trials:

Search ClinicalTrials for Hemorrhage, Intracerebral

Search NIH Clinical Center for Hemorrhage, Intracerebral

Genetic Tests for Hemorrhage, Intracerebral

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Genetic tests related to Hemorrhage, Intracerebral:

id Genetic test Affiliating Genes
1 Hemorrhage, Intracerebral, Susceptibility to22

Anatomical Context for Hemorrhage, Intracerebral

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MalaCards organs/tissues related to Hemorrhage, Intracerebral:

31
Brain

Animal Models for Hemorrhage, Intracerebral or affiliated genes

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MGI Mouse Phenotypes related to Hemorrhage, Intracerebral:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053959.1COL4A2, COL4A1
2MP:00053858.6COL4A1, COL4A2, ACE
3MP:00053978.5ACE, COL4A2, COL4A1
4MP:00053768.5COL4A1, COL4A2, ACE
5MP:00053848.4COL4A1, ACE, COL4A2
6MP:00053788.2COL4A2, COL4A1, ACE

Publications for Hemorrhage, Intracerebral

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Articles related to Hemorrhage, Intracerebral:

idTitleAuthorsYear
1
Terson syndrome in subarachnoid hemorrhage, intracerebral hemorrhage, and traumatic brain injury. (25173620)
2014
2
Progressive manifestations of reversible cerebral vasoconstriction syndrome presenting with subarachnoid hemorrhage, intracerebral hemorrhage, and cerebral infarction. (25535520)
2014
3
Subarachnoid hemorrhage, intracerebral hemorrhage, and intracranial aneurysms. (14914245)
1952

Variations for Hemorrhage, Intracerebral

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Clinvar genetic disease variations for Hemorrhage, Intracerebral:

6
id Gene Variation Type Significance SNP ID Assembly Location
1COL4A2NM_001846.2(COL4A2): c.3368A> G (p.Glu1123Gly)single nucleotide variantrisk factorrs117412802GRCh37Chr 13, 111143601: 111143601
2COL4A2NM_001846.2(COL4A2): c.3448C> A (p.Gln1150Lys)single nucleotide variantrisk factorrs62621875GRCh37Chr 13, 111143681: 111143681
3COL4A2NM_001846.2(COL4A2): c.5068G> A (p.Ala1690Thr)single nucleotide variantrisk factorrs201105747GRCh37Chr 13, 111164467: 111164467
4COL4A1NM_001845.4(COL4A1): c.1055C> T (p.Pro352Leu)single nucleotide variantrisk factorrs200786329GRCh37Chr 13, 110853814: 110853814
5COL4A1NM_001845.4(COL4A1): c.1612C> G (p.Arg538Gly)single nucleotide variantrisk factorrs397514624GRCh37Chr 13, 110839601: 110839601

Expression for genes affiliated with Hemorrhage, Intracerebral

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Search GEO for disease gene expression data for Hemorrhage, Intracerebral.

Pathways for genes affiliated with Hemorrhage, Intracerebral

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Pathways related to Hemorrhage, Intracerebral according to GeneCards Suite gene sharing:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.0COL4A1, COL4A2
2
Show member pathways
Integrin-mediated cell adhesion36
Focal Adhesion36
9.0COL4A1, COL4A2
3
Show member pathways
9.0COL4A2, COL4A1
4
Show member pathways
Cytoskeleton remodeling Fibronectin binding integrins in cell motility58
Cytoskeleton remodeling Integrin outside in signaling58
Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases58
Cell adhesion Tight junctions58
Development MAG dependent inhibition of neurite outgrowth58
9.0COL4A2, COL4A1
59.0COL4A1, COL4A2
6
Show member pathways
9.0COL4A1, COL4A2
7
Show member pathways
9.0COL4A2, COL4A1
8
Show member pathways
9.0COL4A2, COL4A1
9
Show member pathways
9.0COL4A2, COL4A1
10
Show member pathways
9.0COL4A2, COL4A1
119.0COL4A1, COL4A2
12
Show member pathways
9.0COL4A2, COL4A1
139.0COL4A2, COL4A1
149.0COL4A2, COL4A1
15
Show member pathways
9.0COL4A1, COL4A2
169.0COL4A2, COL4A1
17
Show member pathways
Metalloproteases in connective tissue degradation
9.0COL4A1, COL4A2
189.0COL4A2, COL4A1
199.0COL4A2, COL4A1
209.0COL4A1, COL4A2

Compounds for genes affiliated with Hemorrhage, Intracerebral

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Sources:
43Novoseek
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Compounds related to Hemorrhage, Intracerebral according to GeneCards Suite gene sharing:

idCompoundScoreTop Affiliating Genes
1arresten439.0COL4A1, COL4A2

GO Terms for genes affiliated with Hemorrhage, Intracerebral

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Cellular components related to Hemorrhage, Intracerebral according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1collagen type IVGO:00055879.0COL4A1, COL4A2
2endoplasmic reticulum lumenGO:00057889.0COL4A1, COL4A2
3extracellular matrixGO:00310128.7COL4A1, COL4A2
4extracellular regionGO:00055768.4COL4A1, COL4A2, ACE

Biological processes related to Hemorrhage, Intracerebral according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1collagen catabolic processGO:00305749.0COL4A1, COL4A2
2axon guidanceGO:00074119.0COL4A1, COL4A2
3extracellular matrix disassemblyGO:00226178.9COL4A1, COL4A2
4extracellular matrix organizationGO:00301988.7COL4A1, COL4A2

Molecular functions related to Hemorrhage, Intracerebral according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix structural constituentGO:00052019.0COL4A1, COL4A2

Products for genes affiliated with Hemorrhage, Intracerebral

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Hemorrhage, Intracerebral

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet