Hemorrhage, Intracerebral (ICH) malady

Categories: Genetic diseases, Neuronal diseases

Aliases & Classifications for Hemorrhage, Intracerebral

Aliases & Descriptions for Hemorrhage, Intracerebral:

Name: Hemorrhage, Intracerebral 54
Intracerebral Hemorrhage 66 29 52
Hemorrhagic Stroke 66 52 41
Hemorrhage, Intracerebral, Susceptibility to 13
Stroke, Hemorrhagic 54
Cerebral Hemorrhage 42
Brain Hemorrhage 69
Ich 66


External Ids:

OMIM 54 614519
MeSH 42 D002543

Summaries for Hemorrhage, Intracerebral

MedlinePlus : 41 a stroke is a medical emergency. there are two types - ischemic and hemorrhagic. hemorrhagic stroke is the less common type. it happens when a blood vessel breaks and bleeds into the brain. within minutes, brain cells begin to die. causes include a bleeding aneurysm, an arteriovenous malformation (avm), or an artery wall that breaks open. symptoms of stroke are sudden numbness or weakness of the face, arm or leg (especially on one side of the body) sudden confusion, trouble speaking or understanding speech sudden trouble seeing in one or both eyes sudden trouble walking, dizziness, loss of balance or coordination sudden severe headache with no known cause it is important to treat strokes as quickly as possible. with a hemorrhagic stroke, the first steps are to find the cause of bleeding in the brain and then control it. surgery may be needed. post-stroke rehabilitation can help people overcome disabilities caused by stroke damage. national institute of neurological disorders and stroke

MalaCards based summary : Hemorrhage, Intracerebral, also known as intracerebral hemorrhage, is related to cerebral hemorrhage and cerebral amyloid angiopathy, and has symptoms including angina pectoris, back pain and chest pain. An important gene associated with Hemorrhage, Intracerebral is COL4A1 (Collagen Type IV Alpha 1 Chain), and among its related pathways/superpathways are Neuroscience and Binding and Uptake of Ligands by Scavenger Receptors. The drugs Heparin and Nicardipine have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and cortex, and related phenotypes are cardiovascular system and growth/size/body region

UniProtKB/Swiss-Prot : 66 Intracerebral hemorrhage: A pathological condition characterized by bleeding into one or both cerebral hemispheres including the basal ganglia and the cerebral cortex. It is often associated with hypertension and craniocerebral trauma. Intracerebral bleeding is a common cause of stroke.

Wikipedia : 71 Intracerebral hemorrhage (ICH), also known as cerebral bleed, is a type of intracranial bleed that... more...

Description from OMIM: 614519

Related Diseases for Hemorrhage, Intracerebral

Diseases related to Hemorrhage, Intracerebral via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 69)
id Related Disease Score Top Affiliating Genes
1 cerebral hemorrhage 12.1
2 cerebral amyloid angiopathy 11.9
3 cerebral amyloid angiopathy, dutch, italian, iowa, flemish, arctic variants 11.8
4 moyamoya disease 11.1
5 eclampsia 11.1
6 stroke, ischemic 10.8
7 thrombocytopenia, x-linked 10.7
8 cerebral cavernous malformations-1 10.7
9 fara chlupackova syndrome 10.3 COL4A1 COL4A2
10 deafness, autosomal recessive 30 10.2 COL4A1 COL4A2
11 photosensitive epilepsy 10.2 COL4A1 COL4A2
12 inferolateral myocardial infarct 10.2 ACE PLAT
13 melorheostosis 10.2 ACE PLAT
14 secretory diarrhea myopathy and deafness 10.2 ACE PLAT
15 marsden nyhan sakati syndrome 10.2 ACE HMGCR
16 opiate dependence 10.2 ACE CST3
17 lupus erythematosus panniculitis 10.1 ACE APOE
18 juvenile amyotrophic lateral sclerosis with dementia 10.1 ACE APP
19 myopia 10.1 ACE CST3
20 iron metabolism disease 10.1 ACE APOE
21 toxic myocarditis 10.1 ACE CST3
22 charcot-marie-tooth disease 10.1 APP CST3
23 lupus erythematosus 10.1 ACE PLAT
24 pars planitis 10.1 ACE APOE
25 cetp-related hyperalphalipoproteinemia 10.1 ACE APOE
26 joint disorders 10.1 ACE APOE
27 asphyxia neonatorum 10.1 ACE APOE
28 dentinogenesis imperfecta type 2 10.1 APOE HMGCR
29 encephalitozoonosis 10.1 APOE APP
30 severe intellectual disability-progressive postnatal microcephaly- midline stereotypic hand movements syndrome 10.0 APOE HMGCR
31 focal dystonia 10.0 ACE CST3
32 skin squamous cell carcinoma 10.0 APOE HMGCR
33 chronic myocardial ischemia 10.0 ACE CST3 HMGCR
34 bone dysplasia azouz type 10.0 APOE APP
35 limited scleroderma 10.0 APOE APP
36 gait apraxia 10.0 ACE APOE
37 meckel syndrome 10 10.0 APOE APP
38 pyrimidine metabolic disorder 9.9 ACE APOE PLAT
39 pontocerebellar hypoplasia, type 10 9.9 APOE HMGCR
40 lipomatosis 9.9 ACE APOE HMGCR
41 myelophthisic anemia 9.9 ACE APOE HMGCR
42 polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract 9.9 APOE APP CST3
43 autoimmune-related retinopathy and optic neuropathy 9.9 ACE APOE HMGCR
44 hard palate cancer 9.9 APOE APP CST3
45 eumycotic mycetoma 9.9 APOE APP CST3
46 meier-gorlin syndrome 5 9.9 APOE APP
47 hydrocephalus 9.8
48 budd-chiari syndrome 9.8 ACE APOE HMGCR PLAT
49 macular degeneration, age-related, 12 9.8 ACE APOE HMGCR PLAT
50 contagious pustular dermatitis 9.8 ACE APOE APP CST3

Graphical network of the top 20 diseases related to Hemorrhage, Intracerebral:

Diseases related to Hemorrhage, Intracerebral

Symptoms & Phenotypes for Hemorrhage, Intracerebral

Clinical features from OMIM:


UMLS symptoms related to Hemorrhage, Intracerebral:

angina pectoris, back pain, chest pain, edema, headache, pain, sciatica, seizures, syncope, tremor, chronic pain, vertigo/dizziness, sleeplessness

MGI Mouse Phenotypes related to Hemorrhage, Intracerebral:

id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10 COL4A2 CST3 PLAT ACE APOE CCM2
2 growth/size/body region MP:0005378 9.98 ACE APOE APP CCM2 COL4A1 HMGCR
3 homeostasis/metabolism MP:0005376 9.97 ACE APOE APP CCM2 COL4A1 CST3
4 mortality/aging MP:0010768 9.97 ACE APOE APP CCM2 COL4A1 COL4A2
5 hematopoietic system MP:0005397 9.95 ACE APOE APP CCM2 COL4A1 COL4A2
6 muscle MP:0005369 9.73 APOE APP CCM2 COL4A1 CST3 PLAT
7 nervous system MP:0003631 9.7 COL4A2 CST3 PLAT APOE APP CCM2
8 reproductive system MP:0005389 9.43 ACE APOE APP COL4A1 CST3 PLAT
9 vision/eye MP:0005391 9.02 APOE CCM2 COL4A1 COL4A2 PLAT

Drugs & Therapeutics for Hemorrhage, Intracerebral

Drugs for Hemorrhage, Intracerebral (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 297)
id Name Status Phase Clinical Trials Cas Number PubChem Id
Heparin Approved, Investigational Phase 4,Phase 3 9005-49-6 772 46507594
Nicardipine Approved Phase 4,Phase 3,Phase 1 55985-32-5 4474
Clevidipine Approved Phase 4,Phase 3,Phase 2 167221-71-8
Dalteparin Approved Phase 4,Phase 2 9041-08-1
5 Nadroparin Approved Phase 4 9041-08-1
Aspirin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 50-78-2 2244
Ticlopidine Approved Phase 4,Phase 3 55142-85-3 5472
Benzocaine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 1994-09-7, 94-09-7 2337
Ethanol Approved Phase 4,Phase 1,Phase 2 64-17-5 702
Cilostazol Approved Phase 4,Phase 3 73963-72-1 2754
Valproic Acid Approved, Investigational Phase 4 99-66-1 3121
Mannitol Approved, Investigational Phase 4 69-65-8 453 6251
Warfarin Approved Phase 4,Phase 3 81-81-2 6691 54678486
Amlodipine Approved Phase 4 88150-42-9 2162
Olmesartan Approved, Investigational Phase 4 144689-24-7, 144689-63-4 158781 130881
Pitavastatin Approved Phase 4 147511-69-1, 147526-32-7 6366718 5282452
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
Probucol Approved Phase 4 23288-49-5 4912
Indapamide Approved Phase 4 26807-65-8 3702
Telmisartan Approved, Investigational Phase 4 144701-48-4 65999
Menadione Approved, Nutraceutical Phase 4,Phase 3 58-27-5 4055
Phytonadione Approved, Nutraceutical Phase 4,Phase 3 84-80-0 4812 5284607
Clopidogrel Approved, Nutraceutical Phase 4,Phase 3,Phase 2 120202-66-6, 113665-84-2 60606
24 tannic acid Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
Ginseng Approved, Nutraceutical Phase 4 50647-08-0
Caffeine Approved, Nutraceutical Phase 4,Phase 1,Phase 2 58-08-2 2519
Butyric Acid Experimental Phase 4,Phase 2 107-92-6 264
28 Anticoagulants Phase 4,Phase 2,Phase 3,Phase 1
29 Antihypertensive Agents Phase 4,Phase 3,Phase 2,Phase 1
30 calcium channel blockers Phase 4,Phase 3,Phase 2,Phase 1
31 Calcium, Dietary Phase 4,Phase 3,Phase 2,Phase 1
32 Vasodilator Agents Phase 4,Phase 3,Phase 2,Phase 1
33 calcium heparin Phase 4,Phase 3
34 Fibrinolytic Agents Phase 4,Phase 2,Phase 3,Phase 1
35 Heparin, Low-Molecular-Weight Phase 4,Phase 2
36 Plasminogen Phase 4,Phase 3,Phase 2,Phase 1
37 Tissue Plasminogen Activator Phase 4,Phase 3,Phase 2,Phase 1
38 3-n-butylphthalide Phase 4
39 Analgesics Phase 4,Phase 2,Phase 3,Phase 1
40 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 3,Phase 1
41 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Phase 1
42 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 2,Phase 3,Phase 1
43 Antipyretics Phase 4,Phase 2,Phase 3,Phase 1
44 Antirheumatic Agents Phase 4,Phase 2,Phase 3,Phase 1
45 Cyclooxygenase Inhibitors Phase 4,Phase 2,Phase 3,Phase 1
46 Neuroprotective Agents Phase 4,Phase 3
47 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1
48 Platelet Aggregation Inhibitors Phase 4,Phase 2,Phase 3,Phase 1
49 Protective Agents Phase 4,Phase 3,Phase 2
50 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 324)
id Name Status NCT ID Phase
1 Prevention of Venous Thromboembolism in Patients With Acute Primary Intracerebral Hemorrhage Unknown status NCT00699465 Phase 4
2 IV Double and Triple Concentrated Nicardipine for Stroke and ICH Unknown status NCT00325793 Phase 4
3 The Efficacy and Safety of Cleviprex in Ventriculostomy Patients Requiring IV Antihypertensive Therapy Unknown status NCT01042574 Phase 4
4 Low Dose Rt-PA for Acute Normotensive Pulmonary Embolism With RVD Unknown status NCT01531829 Phase 4
5 The Effectiveness and Safety of Butylphthalide Soft Capsules in Secondary Prevention of Ischemic Stroke Trial Unknown status NCT00724724 Phase 4
6 Seizures Post Intracerebral Hemorrhage Completed NCT01115959 Phase 4
7 Clinical Study on the Treatment of Hypertensive Intracerebral Hemorrhage With Panax Notoginseng Saponin Completed NCT02999048 Phase 4
8 International Normalized Ratio (INR) Normalization in Coumadin Associated Intracerebral Haemorrhage Completed NCT00928915 Phase 4
9 COMbination of Clopidogrel and Aspirin for Prevention of Early REcurrence in Acute Atherothrombotic Stroke Completed NCT00814268 Phase 4
10 Temperature Control in Central Fever in the Neuro-ICU Completed NCT00751634 Phase 4
11 MRI and Neurodevelopment in Preterm Infants Following Administration of High-Dose Caffeine Completed NCT00809055 Phase 4
12 Comparative Infection Rates for the Codman BACTISEAL TM External Ventricular Drainage (EVD) System Completed NCT00197392 Phase 4
13 Imaging Guided Patient Selection for Interventional Revascularization Therapy Completed NCT00963989 Phase 4
14 OlmeSartan and Calcium Antagonists Randomized (OSCAR) Study Completed NCT00134160 Phase 4
15 Japan Prevention Trial of Diabetes by Pitavastatin in Patients With Impaired Glucose Tolerance (J-PREDICT) Completed NCT00301392 Phase 4
16 PreventIon of CArdiovascular Events in iSchemic Stroke Patients With High Risk of Cerebral HemOrrhage Active, not recruiting NCT01013532 Phase 4
17 PreventIon of IMT Progression in iSchemic Stroke Patients With High Risk of Cerebral HemOrrhage-IMT Study Active, not recruiting NCT02483169 Phase 4
18 ASCEND: A Study of Cardiovascular Events iN Diabetes Active, not recruiting NCT00135226 Phase 4
19 Clinical Re-evaluation of Removing Blood Stasis Therapy in Treating Acute Cerebral Hemorrhage Safety and Efficacy Enrolling by invitation NCT01918722 Phase 4
20 Triple Therapy Prevention of Recurrent Intracerebral Disease EveNts Trial Not yet recruiting NCT02699645 Phase 4
21 Comparison of Staged Angioplasty and Routine Single-stage Stenting (CAS) in the Treatment of Carotid Artery Stenosis Not yet recruiting NCT02224209 Phase 4
22 Shuxuetong for Prevention of Recurrence in Acute Cerebrovascular Events With Embolism Not yet recruiting NCT03090113 Phase 4
23 Antenatal Rescue Course of Glucocorticoids in Threatened Premature Birth Terminated NCT00295464 Phase 4
24 HydroCoil Cerebral Aneurysm Treatment Trial Terminated NCT01195129 Phase 4
25 Effectiveness and Safety of Rhubarb for the Treatment of Patients Who Have Suffered From Cerebral Hemorrhage Unknown status NCT00815737 Phase 2, Phase 3
26 Pilot Study of Hypothermia for Intracerebral Hemorrhage in Croatia Unknown status NCT01221142 Phase 3
27 Edoxaban for TIA and Acute Minor Stroke Unknown status NCT02221102 Phase 2, Phase 3
28 Treatment of Rivaroxaban Versus Aspirin for Non-disabling Cerebrovascular Events Unknown status NCT01923818 Phase 2, Phase 3
29 Cilostazol Stroke Prevention Study for Antiplatelet Combination Unknown status NCT01995370 Phase 3
30 PROximal Protection VErsus NON-Protection in Carotid Artery Stenting Unknown status NCT01331473 Phase 3
31 Recombinant Factor VIIa in Acute Intracerebral Haemorrhage Completed NCT00127283 Phase 3
32 Clevidipine in the Treatment of Patients With Acute Hypertension and Intracerebral Hemorrhage (ACCELERATE) Completed NCT00666328 Phase 3
33 A Randomised Controlled Trial of Lumbar Drainage to Treat Communicating Hydrocephalus After Severe Intraventricular Hemorrhage Completed NCT01041950 Phase 2, Phase 3
34 Warfarin Versus Aspirin in Reduced Cardiac Ejection Fraction (WARCEF) Trial Completed NCT00041938 Phase 3
35 Clot Lysis: Evaluating Accelerated Resolution of Intraventricular Hemorrhage Phase III Completed NCT00784134 Phase 3
36 Sarpogrelate-Aspirin Comparative Clinical Study for Efficacy and Safety in Secondary Prevention of Cerebral Infarction (S-ACCESS) Completed NCT00129805 Phase 3
37 Secondary Prevention of Small Subcortical Strokes Trial Completed NCT00059306 Phase 3
38 Improving DEtection of Atrial fibriLlation in Primary Care With the MyDiagnostick Completed NCT02270151 Phase 3
39 Study of Tenecteplase Versus Alteplase for Thrombolysis (Clot Dissolving) in Acute Ischemic Stroke Completed NCT01949948 Phase 3
40 Randomized Evaluation of Long Term Anticoagulant Therapy (RE-LY) With Dabigatran Etexilate Completed NCT00262600 Phase 3
41 Indomethacin Germinal Matrix Hemorrhage/Intraventricular Hemorrhage (GMH/IVH) Prevention Trial Completed NCT00033917 Phase 3
42 Antenatal Phenobarbital to Prevent Neonatal Intracranial Hemorrhage Completed NCT00009620 Phase 3
43 Patent Foramen Ovale Closure or Anticoagulants Versus Antiplatelet Therapy to Prevent Stroke Recurrence Completed NCT00562289 Phase 3
44 Beneficial Effects of Antenatal Magnesium Sulfate (BEAM Trial) Completed NCT00014989 Phase 3
45 A RCT to Establish the Effectiveness of Intermittent Pneumatic Compression to Prevent Post Stroke DVT Completed NCT00789542 Phase 3
46 Dexanabinol in Severe Traumatic Brain Injury Completed NCT00129857 Phase 3
47 Treatment of Intracerebral Hemorrhage in Patients on Non-vitamin K Antagonist Recruiting NCT02866838 Phase 2, Phase 3
48 REstart or STop Antithrombotic Randomised Trial in France Recruiting NCT02966119 Phase 3
49 Minimally Invasive Surgery Plus Rt-PA for ICH Evacuation Phase III Recruiting NCT01827046 Phase 3
50 Enhanced Control of Hypertension and Thrombolysis Stroke Study (ENCHANTED) Recruiting NCT01422616 Phase 3

Search NIH Clinical Center for Hemorrhage, Intracerebral

Cochrane evidence based reviews: cerebral hemorrhage

Genetic Tests for Hemorrhage, Intracerebral

Genetic tests related to Hemorrhage, Intracerebral:

id Genetic test Affiliating Genes
1 Hemorrhage, Intracerebral, Susceptibility to 29

Anatomical Context for Hemorrhage, Intracerebral

MalaCards organs/tissues related to Hemorrhage, Intracerebral:

Brain, Eye, Cortex

Publications for Hemorrhage, Intracerebral

Articles related to Hemorrhage, Intracerebral:

id Title Authors Year
Progressive manifestations of reversible cerebral vasoconstriction syndrome presenting with subarachnoid hemorrhage, intracerebral hemorrhage, and cerebral infarction. ( 25535520 )
Terson syndrome in subarachnoid hemorrhage, intracerebral hemorrhage, and traumatic brain injury. ( 25173620 )
Subarachnoid hemorrhage, intracerebral hemorrhage, and intracranial aneurysms. ( 14914245 )

Variations for Hemorrhage, Intracerebral

UniProtKB/Swiss-Prot genetic disease variations for Hemorrhage, Intracerebral:

id Symbol AA change Variation ID SNP ID
1 COL4A1 p.Pro352Leu VAR_073810
2 COL4A1 p.Arg538Gly VAR_073811

ClinVar genetic disease variations for Hemorrhage, Intracerebral:

id Gene Variation Type Significance SNP ID Assembly Location
1 ACE NM_000789.3(ACE): c.2306-117_2306-116insAF118569.1: g.14094_14382 insertion risk factor rs4340 GRCh37 Chromosome 17, 61565892: 61565893
2 COL4A2 NM_001846.3(COL4A2): c.3368A> G (p.Glu1123Gly) single nucleotide variant risk factor rs117412802 GRCh37 Chromosome 13, 111143601: 111143601
3 COL4A2 NM_001846.3(COL4A2): c.3448C> A (p.Gln1150Lys) single nucleotide variant risk factor rs62621875 GRCh37 Chromosome 13, 111143681: 111143681
4 COL4A2 NM_001846.3(COL4A2): c.5068G> A (p.Ala1690Thr) single nucleotide variant risk factor rs201105747 GRCh37 Chromosome 13, 111164467: 111164467
5 COL4A1 NM_001845.5(COL4A1): c.1055C> T (p.Pro352Leu) single nucleotide variant risk factor rs200786329 GRCh37 Chromosome 13, 110853814: 110853814
6 COL4A1 NM_001845.5(COL4A1): c.1612C> G (p.Arg538Gly) single nucleotide variant risk factor rs397514624 GRCh37 Chromosome 13, 110839601: 110839601

Expression for Hemorrhage, Intracerebral

Search GEO for disease gene expression data for Hemorrhage, Intracerebral.

Pathways for Hemorrhage, Intracerebral

GO Terms for Hemorrhage, Intracerebral

Cellular components related to Hemorrhage, Intracerebral according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.88 ACE APOE APP COL4A2 CST3 PLAT
2 extracellular region GO:0005576 9.8 ACE APOE APP COL4A1 COL4A2 CST3
3 extracellular matrix GO:0031012 9.62 APOE COL4A1 COL4A2 PLAT
4 basement membrane GO:0005604 9.54 COL4A1 COL4A2 CST3
5 extracellular space GO:0005615 9.5 ACE APOE APP COL4A1 COL4A2 CST3
6 collagen type IV trimer GO:0005587 9.16 COL4A1 COL4A2
7 endoplasmic reticulum lumen GO:0005788 9.02 APOE APP COL4A1 COL4A2 CST3

Biological processes related to Hemorrhage, Intracerebral according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.54 APOE APP CST3
2 extracellular matrix organization GO:0030198 9.5 APP COL4A1 COL4A2
3 visual learning GO:0008542 9.43 APP HMGCR
4 negative regulation of MAP kinase activity GO:0043407 9.4 APOE HMGCR
5 response to oxidative stress GO:0006979 9.33 APOE APP CST3
6 negative regulation of proteolysis GO:0045861 9.26 CST3 PLAT
7 collagen-activated tyrosine kinase receptor signaling pathway GO:0038063 8.96 COL4A1 COL4A2
8 cholesterol metabolic process GO:0008203 8.8 APOE APP HMGCR

Molecular functions related to Hemorrhage, Intracerebral according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 beta-amyloid binding GO:0001540 8.62 APOE CST3

Sources for Hemorrhage, Intracerebral

9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
52 Novoseek
55 OMIM via Orphanet
59 PubMed
65 SNOMED-CT via Orphanet
68 Tocris
70 UMLS via Orphanet
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