MCID: HMR012
MIFTS: 60

Hemorrhagic Fever

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Hemorrhagic Fever

Summaries for Hemorrhagic Fever

MedlinePlus : 40 Viral hemorrhagic fevers (VHFs) are a group of illnesses caused by four families of viruses. These include the Ebola and Marburg, Lassa fever, and yellow fever viruses. VHFs have common features: they affect many organs, they damage the blood vessels, and they affect the body's ability to regulate itself. Some VHFs cause mild disease, but some, like Ebola or Marburg, cause severe disease and death. VHFs are found around the world. Specific diseases are usually limited to areas where the animals that carry them live. For example, Lassa fever is limited to rural areas of West Africa where rats and mice carry the virus. The risk for travelers is low, but you should avoid visiting areas where there are disease outbreaks. Because there are no effective treatments for some of these viral infections, there is concern about their use in bioterrorism. Centers for Disease Control and Prevention

MalaCards based summary : Hemorrhagic Fever, also known as hemorrhagic fevers, viral, is related to marburg hemorrhagic fever and crimean-congo hemorrhagic fever, and has symptoms including pruritus and fever. An important gene associated with Hemorrhagic Fever is CD209 (CD209 Molecule), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Influenza A. The drugs Histamine and Ketotifen have been mentioned in the context of this disorder. Affiliated tissues include testes, endothelial and t cells, and related phenotypes are cardiovascular system and homeostasis/metabolism

CDC : 3 VHFs are caused by viruses of five distinct families: Arenaviridae, Bunyaviridae, Filoviridae, Flaviviridae, and Paramyxoviridae. Each of these families share a number of features:

Related Diseases for Hemorrhagic Fever

Diseases in the Hemorrhagic Fever family:

Viral Hemorrhagic Fever

Diseases related to Hemorrhagic Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 452)
# Related Disease Score Top Affiliating Genes
1 marburg hemorrhagic fever 34.2 CD209 F2 TNF
2 crimean-congo hemorrhagic fever 34.1 F3 IL6 TNF
3 korean hemorrhagic fever 33.0 CD40LG F2 F3 SERPINC1
4 hemorrhagic fever with renal syndrome 32.4 ALB CD40LG HLA-DRB1 IL10 IL6 TNF
5 hantavirus pulmonary syndrome 31.6 CD40LG F2 F3
6 dengue shock syndrome 30.7 HLA-DRB1 IL6 TNF
7 dengue hemorrhagic fever 30.4 ALB CD209 CD40LG F2 F3 HLA-DRB1
8 hemophagocytic lymphohistiocytosis 30.2 IFNG IL10 TNF
9 myocarditis 29.9 CD40LG IL6 TNF
10 disseminated intravascular coagulation 29.7 F2 F3 SERPINC1
11 tick-borne encephalitis 29.7 ALB CD209 IL10
12 cholecystitis 29.7 ALB F2 GPT
13 hepatitis 29.6 F2 GPT SLC17A5 TNF
14 chikungunya 29.5 CD40LG IL6 TNF
15 leishmaniasis 29.4 HLA-DRB1 IFNG IL10 TNF
16 severe acute respiratory syndrome 29.4 CD209 CD40LG IFNG TNF
17 purpura fulminans 29.3 F2 F3 SERPINC1
18 pneumonia 29.3 CD40LG IL10 IL6 TNF
19 hemorrhagic disease 29.2 F2 F3 SERPINC1
20 leptospirosis 29.2 CD40LG F2 IL10 IL6 TNF
21 bilirubin metabolic disorder 29.1 ALB F2 GPT
22 visceral leishmaniasis 29.0 ALB IFNG IL10 TNF
23 appendicitis 29.0 ALB IL10 IL6 TNF
24 brucellosis 28.9 CD40LG IFNG IL10 IL6 TNF
25 chlamydia 28.9 CD40LG IFNG IL10 IL6 TNF
26 kawasaki disease 28.9 ALB IL10 IL6 TNF
27 typhoid fever 28.9 ALB IFNG IL6 TNF
28 acute liver failure 28.8 ALB F2 GPT SLC17A5
29 purpura 28.7 CD40LG F2 F3 SERPINC1 TNF
30 compartment syndrome 28.7 ALB F2 SLC17A5 TNF
31 filariasis 28.6 ALB IFNG IL10 IL6 TNF
32 peritonitis 28.3 ALB F2 IFNG IL10 IL6 TNF
33 scrub typhus 28.1 CD40LG F3 GPT IL10 SLC17A5 TNF
34 acquired immunodeficiency syndrome 28.0 ALB CD40LG IFNG IL10 IL6 TNF
35 hepatitis a 27.9 ALB F2 F3 GPT SERPINC1 TNF
36 hepatitis b 27.8 ALB F2 GPT IFNG SLC17A5 TNF
37 malaria 27.0 ALB CD40LG F3 HLA-DRB1 IFNG IL10
38 myocardial infarction 26.9 ALB CD40LG F2 F3 IL10 IL6
39 omsk hemorrhagic fever 12.5
40 argentine hemorrhagic fever 12.5
41 bolivian hemorrhagic fever 12.5
42 ebola hemorrhagic fever 12.5
43 venezuelan hemorrhagic fever 12.4
44 alkhurma hemorrhagic fever 12.4
45 lujo hemorrhagic fever 12.4
46 viral hemorrhagic fever 12.4
47 brazilian hemorrhagic fever 12.3
48 chapare hemorrhagic fever 12.3
49 whitewater arroyo hemorrhagic fever 12.2
50 balkan hemorrhagic fever 12.2

Graphical network of the top 20 diseases related to Hemorrhagic Fever:



Diseases related to Hemorrhagic Fever

Symptoms & Phenotypes for Hemorrhagic Fever

UMLS symptoms related to Hemorrhagic Fever:


pruritus, fever

MGI Mouse Phenotypes related to Hemorrhagic Fever:

43 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.18 TFRC IL6 TNF SERPINC1 F2 IL10
2 homeostasis/metabolism MP:0005376 10.17 TFRC IL6 TNF SERPINC1 SLC17A5 F2
3 cellular MP:0005384 10.16 IL10 TFRC IL6 TNF SLC17A5 CD40LG
4 hematopoietic system MP:0005397 10.11 TFRC IL6 TNF SERPINC1 IL10 IFNG
5 immune system MP:0005387 10.06 TFRC IL6 TNF SERPINC1 IL10 CD40LG
6 digestive/alimentary MP:0005381 10.04 TFRC IL6 TNF F2 IL10 ALB
7 embryo MP:0005380 10.02 IL10 TFRC TNF SERPINC1 IFNG F2
8 mortality/aging MP:0010768 10 TFRC IL6 TNF SERPINC1 SLC17A5 F2
9 integument MP:0010771 9.97 TFRC IL6 TNF F2 IL10 F3
10 liver/biliary system MP:0005370 9.87 TFRC IL6 TNF SERPINC1 IL10 ALB
11 nervous system MP:0003631 9.65 TFRC IL6 TNF SERPINC1 SLC17A5 F2
12 neoplasm MP:0002006 9.63 IL6 TNF IFNG IL10 F3 ALB
13 vision/eye MP:0005391 9.17 IL6 TNF SERPINC1 SLC17A5 IFNG IL10

Drugs & Therapeutics for Hemorrhagic Fever

Drugs for Hemorrhagic Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 119)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Histamine Approved, Investigational Phase 4 51-45-6, 75614-87-8 774
2
Ketotifen Approved Phase 4 34580-13-7, 34580-14-8 3827
3
Benzocaine Approved, Investigational Phase 4,Phase 1,Phase 2 1994-09-7, 94-09-7 2337
4
Menthol Approved Phase 4 2216-51-5 16666
5 tannic acid Approved, Nutraceutical Phase 4,Phase 1,Phase 2
6
Histamine Phosphate Phase 4 51-74-1 65513
7 Neurotransmitter Agents Phase 4
8 Vaccines Phase 4,Phase 3,Phase 2,Phase 1
9 Histamine Antagonists Phase 4
10 Histamine H1 Antagonists Phase 4
11 Dermatologic Agents Phase 4,Phase 1,Phase 2
12 Anti-Allergic Agents Phase 4
13 Antipruritics Phase 4
14 Vasoconstrictor Agents Phase 4
15
Ivermectin Approved, Investigational, Vet_approved Phase 2, Phase 3 70288-86-7 46936176 6474909
16
Loperamide Approved Phase 2, Phase 3 53179-11-6 3955
17
Vitamin A Approved, Nutraceutical, Vet_approved Phase 3 68-26-8, 11103-57-4 445354
18
Lactitol Investigational Phase 3 585-86-4 3871
19 DEET Phase 3
20 Pharmaceutical Solutions Phase 3,Phase 2,Phase 1
21 Anti-Infective Agents Phase 2, Phase 3, Phase 1
22 Immunoglobulins Phase 3,Phase 1,Phase 2
23 Insect Repellents Phase 3
24 Protective Agents Phase 3,Phase 1
25 Antibodies Phase 3,Phase 1,Phase 2
26 Antiparasitic Agents Phase 2, Phase 3,Phase 1
27 Heptavalent Pneumococcal Conjugate Vaccine Phase 3,Phase 2
28 Vitamins Phase 3,Phase 2
29 Antibodies, Blocking Phase 3
30 Anti-Bacterial Agents Phase 2, Phase 3,Phase 1
31 Krestin Phase 3,Phase 2,Phase 1
32 Iron-Dextran Complex Phase 3
33 Retinol palmitate Phase 3
34 Micronutrients Phase 3
35 Trace Elements Phase 3
36 Antioxidants Phase 3
37 retinol Nutraceutical Phase 3
38
chloroquine Approved, Investigational, Vet_approved Phase 1, Phase 2 54-05-7 2719
39
Irbesartan Approved, Investigational Phase 1, Phase 2 138402-11-6 3749
40
Ribavirin Approved Phase 2 36791-04-5 37542
41
Hydrocortisone Approved, Vet_approved Phase 2 50-23-7 657311 5754
42
Angiotensin II Approved, Investigational Phase 1, Phase 2 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
43
Azithromycin Approved Phase 1, Phase 2 83905-01-5 53477736 447043 55185
44
Sunitinib Approved, Investigational Phase 1, Phase 2 341031-54-7, 557795-19-4 5329102
45
Coal tar Approved Phase 1, Phase 2 8007-45-2
46
Epinephrine Approved, Vet_approved Phase 2,Phase 1 51-43-4 5816
47
Neomycin Approved, Vet_approved Phase 1, Phase 2 1404-04-2 8378
48
Artemether Approved Phase 2 71963-77-4 68911 119380
49
Lumefantrine Approved Phase 2 82186-77-4 6437380
50 Racepinephrine Approved Phase 2,Phase 1 329-65-7

Interventional clinical trials:

(show top 50) (show all 241)

# Name Status NCT ID Phase Drugs
1 Ketotifen as a Treatment for Vascular Leakage During Dengue Fever Unknown status NCT02673840 Phase 4 Ketotifen;Placebo
2 High Frequency Ventilation During Off Pump Coronary Artery Bypass Graft (CABG) Completed NCT00863044 Phase 4
3 International Multicenter Study of the Immunogenicity of Medicinal Product GamEvac-Combi Recruiting NCT03072030 Phase 4
4 Immunogenicity of Co-administered Yellow Fever and Measles, Mumps, and Rubella (MMR) Vaccines Recruiting NCT03368495 Phase 4
5 Immunogenicity and Safety of the Yellow Fever Vaccine in HIV Infected Individuals Recruiting NCT03132311 Phase 4
6 Immunity Period After One Dose of Yellow Fever Vaccine in Adults and Children (Paraiba Study) Recruiting NCT02555072 Phase 4
7 Immunogenicity and Safety of Fractional Doses of Yellow Fever Vaccines (YEFE) Active, not recruiting NCT02991495 Phase 4
8 Study of a Novel Tetravalent Dengue Vaccine in Healthy Children Aged 2 to 14 Years in Asia Unknown status NCT01373281 Phase 3
9 Effect of Hypertonic Sodium Lactate on sVCAM-1 Level as Surrogate Marker of Endothelial Capillary Leakage in Pediatric Dengue Shock Syndrome Patients (DSS) Unknown status NCT00966628 Phase 3 Hypertonic sodium lactate;Ringer's lactate
10 Efficacy and Safety of Ivermectin Against Dengue Infection Unknown status NCT02045069 Phase 2, Phase 3 2 days Ivermectin;3 days Ivermectin;Placebo
11 Clinical Evaluation of Insect Repellent and Insecticide Treated Nets in Lao PDR Unknown status NCT00938379 Phase 3 20% deet insect repellent;placebo control
12 STRIVE (Sierra Leone Trial to Introduce a Vaccine Against Ebola) Completed NCT02378753 Phase 2, Phase 3
13 Study of a Tetravalent Dengue Vaccine in Healthy Children Aged 2 to 11 Years in Malaysia Completed NCT01254422 Phase 3
14 Study to Evalutate Long-term Immunity of Hantavax in High Risk Population of HFRS Completed NCT02360514 Phase 3 Hantavax injection
15 Emergency Evaluation of Convalescent Plasma for Ebola Viral Disease (EVD) in Guinea Completed NCT02342171 Phase 2, Phase 3
16 Study of a Booster Injection of Pentaxim™ Vaccine Administered With Dengue Vaccine in Healthy Toddlers Completed NCT01411241 Phase 3
17 Study of a Tetravalent Dengue Vaccine in Healthy Adults in Australia Completed NCT01134263 Phase 3
18 Study of Yellow Fever Vaccine Administered With Tetravalent Dengue Vaccine in Healthy Toddlers Completed NCT01436396 Phase 3
19 Evaluation of the Safety and Immunogenicity of Three Consistency Lots and a High-Dose Lot of rVSV-ZEBOV-GP (V920 Ebola Vaccine) in Healthy Adults (V920-012) Completed NCT02503202 Phase 3
20 A Phase 3b, Randomized, Open-Label Study to Evaluate the Safety and Immunogenicity of Select Travel Vaccines When Administered Concomitantly With MenACWY in Adults Completed NCT01466387 Phase 3
21 Long-term Safety Follow-up of Participants Exposed to the Candidate Ebola Vaccines Ad26.ZEBOV and/or MVA-BN-Filo Recruiting NCT02661464 Phase 3
22 Staged Phase 3 Study to Assess the Safety and Immunogenicity of Ebola Candidate Vaccines Ad26.ZEBOV and MVA-BN-Filo During Implementation of Stages 1 and 2 Recruiting NCT02509494 Phase 3
23 Immunogenicity and Safety of Tetravalent Dengue Vaccine (TDV) in Adolescents in Non-Endemic Area(s) Recruiting NCT03341637 Phase 3
24 Phase III Trial to Evaluate Efficacy and Safety of a Tetravalent Dengue Vaccine Recruiting NCT02406729 Phase 3
25 Study of a Tetravalent Dengue Vaccine Administered Concomitantly or Sequentially With Adacel® in Healthy Subjects Active, not recruiting NCT02992418 Phase 3
26 Immunogenicity and Safety of a Tetravalent Dengue Vaccine Administered Concomitantly or Sequentially With Gardasil® Active, not recruiting NCT02993757 Phase 3
27 Immunogenicity and Safety of a Tetravalent Dengue Vaccine Administered Concomitantly or Sequentially With Cervarix® Active, not recruiting NCT02979535 Phase 3
28 Study of a Novel Tetravalent Dengue Vaccine in Healthy Children and Adolescents Aged 9 to 16 Years in Latin America Active, not recruiting NCT01374516 Phase 3
29 Immunogenicity and Safety Study of GSK Biologicals' Candidate Malaria Vaccine Given at 6, 7.5 and 9 Months of Age in Co-administration With Measles, Rubella and Yellow Fever (YF) Vaccines Followed by a Booster of the Malaria Vaccine. Active, not recruiting NCT02699099 Phase 3
30 The Yellow Fever Vaccine Immunity in HIV Infected Patients : Development of New Assays for Virological and Immunological Monitoring in HIV Infected Patient. Active, not recruiting NCT01426243 Phase 3
31 Lot-to-lot Consistency of 3 Lots of Tetravalent Dengue Vaccine (TDV) in Non-endemic Country(Ies) for Dengue Not yet recruiting NCT03423173 Phase 3
32 Immunogenicity and Safety of Tetravalent Dengue Vaccine (TDV) Administered With a Yellow Fever Vaccine in Adults Not yet recruiting NCT03342898 Phase 3
33 Providing Additional Information on the Safety and Effectiveness of an Ebola Vaccine Suspended NCT03161366 Phase 3
34 Clinical Study to Assess Efficacy and Safety of Amiodarone in Treating Patients With Ebola. Virus Disease (EVD) in Sierra Leone. EASE (EMERGENCY Amiodarone Study Against Ebola) Withdrawn NCT02307591 Phase 2, Phase 3 Best Supportive Care;Best Supportive Care + Amiodarone
35 Chinese and Western Medicine Treatment of Fever Associated With Bleeding Symptoms Unknown status NCT01973855 Phase 2 Western Medicine;TCM and Western Medicine
36 Treatment of Japanese Encephalitis Unknown status NCT00216268 Phase 2 Ribavirin
37 Multiple Treatments for Ebola Virus Disease (EVD) Unknown status NCT02380625 Phase 1, Phase 2 Azithromycin;Sunitinib and Erlotinib;Atorvastatin and Irbesartan
38 The Effect of Chloroquine in the Treatment of Patients With Dengue Unknown status NCT00849602 Phase 1, Phase 2 Placebo;Chloroquine
39 Activated Recombinant Human Factor VII in Patients With Dengue Haemorrhagic Fever Completed NCT01601613 Phase 2 activated recombinant human factor VII;placebo
40 Study of CYD Dengue Vaccine in Healthy Children and Adolescents in South America Completed NCT01187433 Phase 2
41 A Study of Dengue Vaccine in Healthy Toddlers Aged 12 to 15 Months in the Philippines Completed NCT01064141 Phase 2
42 Immunogenicity and Safety of Three Formulations of Dengue Vaccines in Healthy Adults Aged 18 to 45 Years in the US Completed NCT00617344 Phase 2
43 Study of a Tetravalent Dengue Vaccine in Healthy Adult Subjects Aged 18 to 45 Years in India Completed NCT01550289 Phase 2
44 Safety and Immunogenicity of Formulations of Dengue Vaccines in Healthy Flavivirus-Naïve Adults Completed NCT00740155 Phase 2
45 Study of ChimeriVax™ Dengue Tetravalent Vaccine in Adult Subjects Completed NCT00730288 Phase 2
46 Immunogenicity and Safety of Sanofi Pasteur's CYD Dengue Vaccine in Healthy Children and Adolescents in Latin America Completed NCT00993447 Phase 2
47 Study of Sanofi Pasteur's CYD Dengue Vaccine in Healthy Subjects in Singapore Completed NCT00880893 Phase 2
48 Study of ChimeriVax™ Tetravalent Dengue Vaccine in Healthy Subjects Completed NCT00875524 Phase 2
49 Efficacy and Safety of Dengue Vaccine in Healthy Children Completed NCT00842530 Phase 2
50 Study of ChimeriVax™ Tetravalent Dengue Vaccine in Healthy Peruvian Children Aged 2 to 11 Years Completed NCT00788151 Phase 2

Search NIH Clinical Center for Hemorrhagic Fever

Genetic Tests for Hemorrhagic Fever

Anatomical Context for Hemorrhagic Fever

MalaCards organs/tissues related to Hemorrhagic Fever:

38
Testes, Endothelial, T Cells, Kidney, Liver, Monocytes, Pituitary

Publications for Hemorrhagic Fever

Articles related to Hemorrhagic Fever:

(show top 50) (show all 1851)
# Title Authors Year
1
Differential Regulation of PAI-1 in Hantavirus Cardiopulmonary Syndrome and Hemorrhagic Fever With Renal Syndrome. ( 29450213 )
2018
2
Host preferences support the prominent role of Hyalomma ticks in the ecology of Crimean-Congo hemorrhagic fever. ( 29420542 )
2018
3
Analysis of codon usage bias of Crimean-Congo hemorrhagic fever virus and its adaptation to hosts. ( 29198972 )
2018
4
Lethal infection of embryonated chicken eggs by Hazara virus, a model for Crimean-Congo hemorrhagic fever virus. ( 29030708 )
2018
5
Erratum for Madelain et al., "Favipiravir Pharmacokinetics in Nonhuman Primates and Insights for Future Efficacy Studies of Hemorrhagic Fever Viruses". ( 29269432 )
2018
6
Structure-Function Assays for Crimean-Congo Hemorrhagic Fever Virus Polymerase. ( 28986838 )
2018
7
Characteristics of headache and its relationship with disease severity in patients with Crimean-Congo hemorrhagic fever. ( 29450871 )
2018
8
Evaluation of the associations between endothelial dysfunction, inflammation and coagulation in Crimean-Congo hemorrhagic fever patients. ( 29159591 )
2018
9
Phylodynamics of Crimean Congo hemorrhagic fever virus in South Russia. ( 29413882 )
2018
10
A novel double-antigen sandwich ELISA for the species-independent detection of Crimean-Congo hemorrhagic fever virus-specific antibodies. ( 29330092 )
2018
11
Murine Models for Viral Hemorrhagic Fever. ( 28986841 )
2018
12
Dynamics of viral load in Crimean Congo hemorrhagic fever. ( 29091325 )
2018
13
Sequence Optimized Real-Time Reverse Transcription Polymerase Chain Reaction Assay for Detection of Crimean-Congo Hemorrhagic Fever Virus. ( 29165231 )
2018
14
A Primate Model for Viral Hemorrhagic Fever. ( 28986843 )
2018
15
Protective effectiveness of inactivated hantavirus vaccine against hemorrhagic fever with renal syndrome. ( 29373686 )
2018
16
Investigation of an isolated case of human Crimean-Congo hemorrhagic fever in Central Uganda, 2015. ( 29382607 )
2018
17
Spatial-Temporal Analysis of Dengue Fever and Hemorrhagic Fever in Mexico from 1995-2015. ( 29402463 )
2018
18
Risk of Venous Thromboembolism Following Hemorrhagic Fever With Renal Syndrome: A Self-controlled Case Series Study. ( 29020303 )
2018
19
Ultrastructural Features of Alkhumra Hemorrhagic Fever Virus Infection of Cells Under In Vivo and In Vitro Conditions. ( 29298405 )
2018
20
Second International Conference on Crimean-Congo Hemorrhagic Fever. ( 29199036 )
2018
21
Dengue Hemorrhagic Fever Virus in Saudi Arabia: A Review. ( 29319426 )
2018
22
Landscape and rodent community composition are associated with risk of hemorrhagic fever with renal syndrome in two cities in China, 2006-2013. ( 29329512 )
2018
23
Enhancing the antiviral potency of ER I+-glucosidase inhibitor IHVR-19029 against hemorrhagic fever viruses in vitro and in vivo. ( 29253498 )
2018
24
Mapping the epidemic changes and risks of hemorrhagic fever with renal syndrome in Shaanxi Province, China, 2005-2016. ( 29335595 )
2018
25
Electron Microscopy of Alkhumra Hemorrhagic Fever Virus. ( 28051359 )
2017
26
Dengue hemorrhagic fever complicated with transient diabetic ketoacidosis: a case report. ( 29078811 )
2017
27
Disposable cartridge platform for rapid detection of viral hemorrhagic fever viruses. ( 28194457 )
2017
28
A Correlation of the Platelet Count with D-Dimer Levels as an Indicator for Component Therapy in Children with Dengue Hemorrhagic Fever. ( 28596655 )
2017
29
Corrigendum to "Does Comorbidity Increase the Risk of Dengue Hemorrhagic Fever and Dengue Shock Syndrome?" ( 29360109 )
2017
30
Analysis of hemorrhagic fever with renal syndrome and its pathogenic gene sequence based on geographic information system. ( 28685549 )
2017
31
Seroepidemiology and risk factors of Crimean-Congo Hemorrhagic Fever among butchers and slaughterhouse workers in southeastern Iran. ( 28935247 )
2017
32
A DNA vaccine for Crimean-Congo hemorrhagic fever protects against disease and death in two lethal mouse models. ( 28922426 )
2017
33
Lack of association between integrin I+vI^3 gene polymorphisms and hemorrhagic fever with renal syndrome in Han Chinese from Hubei, China. ( 28190175 )
2017
34
Serum cytokine/chemokine profiles in patients with dengue fever (DF) and dengue hemorrhagic fever (FHD) by using protein array. ( 28242509 )
2017
35
Management dilemmas in a rare case of pituitary apoplexy in the setting of dengue hemorrhagic fever. ( 28217383 )
2017
36
Space-time epidemiology of Crimean-Congo hemorrhagic fever (CCHF) in Iran. ( 28943247 )
2017
37
Alkhurma hemorrhagic fever virus. ( 28456648 )
2017
38
Co-circulation of Crimean-Congo Hemorrhagic Fever virus strains Asia 1 and 2 between the border of Iran and Pakistan. ( 29159319 )
2017
39
Convergent immunological solutions to Argentine hemorrhagic fever virus neutralization. ( 28630325 )
2017
40
Novel Identified HLA-A*0201-Restricted Hantaan Virus Glycoprotein Cytotoxic T-Cell Epitopes Could Effectively Induce Protective Responses in HLA-A2.1/K<sup>b</sup>Transgenic Mice May Associate with the Severity of Hemorrhagic Fever with Renal Syndrome. ( 29312318 )
2017
41
Effect of TLR10 (2322A/G, 720A/C, and 992T/A) polymorphisms on the pathogenesis of Crimean Congo hemorrhagic fever disease. ( 28843003 )
2017
42
Exploring the Immunopathogenesis of Viral Hemorrhagic Fever in Mice with a Humanized Immune System. ( 29018450 )
2017
43
Interferon-I^-Driven iNOS: A Molecular Pathway to Terminal Shock in Arenavirus Hemorrhagic Fever. ( 28826838 )
2017
44
Crimean-Congo Hemorrhagic Fever Virus Suppresses Innate Immune Responses via a Ubiquitin and ISG15 Specific Protease. ( 28877473 )
2017
45
Vitamin D serostatus and dengue fever progression to dengue hemorrhagic fever/dengue shock syndrome. ( 28903788 )
2017
46
Brucellosis in Patients with Crimean-Congo Hemorrhagic Fever. ( 29367923 )
2017
47
Infection prevention and control practice for Crimean-Congo hemorrhagic fever-A multi-center cross-sectional survey in Eurasia. ( 28886039 )
2017
48
Hantavirus retinitis and concurrent hemorrhagic fever with renal syndrome. ( 28237172 )
2017
49
Hemorrhagic fever with renal syndrome in Albania. Focus on predictors of acute kidney injury in HFRS. ( 28411480 )
2017
50
Serum Cytokine Profiles Differentiating Hemorrhagic Fever with Renal Syndrome and Hantavirus Pulmonary Syndrome. ( 28572804 )
2017

Variations for Hemorrhagic Fever

Expression for Hemorrhagic Fever

Search GEO for disease gene expression data for Hemorrhagic Fever.

Pathways for Hemorrhagic Fever

Pathways related to Hemorrhagic Fever according to GeneCards Suite gene sharing:

(show all 39)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.27 CD40LG HLA-DRB1 IFNG IL10 IL6 TNF
2
Show member pathways
12.73 CD209 HLA-DRB1 IFNG IL6 TNF
3
Show member pathways
12.73 CD40LG HLA-DRB1 IFNG IL10 IL6 TNF
4
Show member pathways
12.57 CD40LG HLA-DRB1 IFNG IL10 TNF
5
Show member pathways
12.53 HLA-DRB1 IFNG IL10 IL6 TNF
6
Show member pathways
12.51 F2 IFNG IL10 IL6 TNF
7 12.48 CD40LG IFNG IL10 TNF
8
Show member pathways
12.45 IFNG IL10 IL6 TNF
9
Show member pathways
12.36 CD40LG IFNG IL10 IL6 TNF
10
Show member pathways
12.21 ALB F2 IFNG IL6 TNF
11
Show member pathways
12.1 CD40LG HLA-DRB1 IFNG IL10 TNF
12
Show member pathways
12.08 IFNG IL10 IL6 TNF
13 11.93 IFNG IL6 TNF
14 11.91 IL10 IL6 TNF
15 11.89 CD209 HLA-DRB1 IFNG IL10 IL6 TNF
16
Show member pathways
11.88 IFNG IL10 IL6 TNF
17 11.84 IFNG IL6 TFRC
18 11.83 F3 IL6 TNF
19 11.83 CD209 IFNG IL10 IL6 TNF
20 11.82 HLA-DRB1 IL6 TFRC TNF
21 11.81 IFNG IL10 IL6 TNF
22 11.75 HLA-DRB1 IFNG IL6 TNF
23 11.73 IFNG IL10 TNF
24
Show member pathways
11.71 CD40LG IFNG TNF
25 11.7 IL10 IL6 TNF
26 11.58 CD40LG IL10 IL6 TNF
27 11.52 IFNG IL6 TNF
28 11.52 CD209 IFNG IL10 IL6 TNF
29
Show member pathways
11.5 CD40LG IFNG IL6 TNF
30 11.49 IL10 IL6 TNF
31 11.45 IFNG IL6 TNF
32 11.43 ALB F2 TFRC
33
Show member pathways
11.34 IFNG IL10 TNF
34 11.32 IL10 IL6 TNF
35 11.26 IFNG IL6 TNF
36 11.17 IFNG IL10 IL6 TNF
37 11.16 CD40LG IL10 IL6 TNF
38 11.04 CD40LG IFNG IL10 IL6 TNF
39 10.5 HLA-DRB1 IFNG IL10 IL6 TNF

GO Terms for Hemorrhagic Fever

Cellular components related to Hemorrhagic Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.73 CD209 CD40LG F3 HLA-DRB1 TFRC TNF
2 extracellular region GO:0005576 9.7 ALB CD209 CD40LG F2 F3 IFNG
3 endoplasmic reticulum lumen GO:0005788 9.67 ALB F2 IL6 SERPINC1
4 external side of plasma membrane GO:0009897 9.63 CD209 CD40LG F2 HLA-DRB1 TFRC TNF
5 blood microparticle GO:0072562 9.62 ALB F2 SERPINC1 TFRC
6 extracellular space GO:0005615 9.36 ALB CD40LG F2 F3 GPT IFNG

Biological processes related to Hemorrhagic Fever according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.81 ALB F2 IL6 SERPINC1
2 cellular response to lipopolysaccharide GO:0071222 9.78 IL10 IL6 TNF
3 platelet activation GO:0030168 9.77 CD40LG F2 IL6
4 positive regulation of DNA binding transcription factor activity GO:0051091 9.75 IL10 IL6 TNF
5 viral entry into host cell GO:0046718 9.73 CD209 HLA-DRB1 TFRC
6 response to glucocorticoid GO:0051384 9.7 IL10 IL6 TNF
7 humoral immune response GO:0006959 9.65 IFNG IL6 TNF
8 hemostasis GO:0007599 9.63 F2 F3 SERPINC1
9 immune response GO:0006955 9.63 CD40LG HLA-DRB1 IFNG IL10 IL6 TNF
10 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.6 IFNG TNF
11 negative regulation of growth of symbiont in host GO:0044130 9.58 IL10 TNF
12 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.57 IL10 TNF
13 negative regulation of lipid storage GO:0010888 9.55 IL6 TNF
14 endothelial cell apoptotic process GO:0072577 9.54 IL10 TNF
15 negative regulation of cytokine secretion involved in immune response GO:0002740 9.49 IL10 TNF
16 positive regulation of STAT protein import into nucleus GO:2000366 9.43 F2 IL6
17 regulation of receptor activity GO:0010469 9.43 CD40LG F2 IFNG IL10 IL6 TNF
18 regulation of immunoglobulin secretion GO:0051023 9.4 CD40LG TNF
19 receptor biosynthetic process GO:0032800 9.37 IL10 TNF
20 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.32 IFNG TNF
21 positive regulation of vitamin D biosynthetic process GO:0060557 9.26 IFNG TNF
22 positive regulation of T cell proliferation GO:0042102 8.92 CD209 CD40LG IL6 TFRC

Molecular functions related to Hemorrhagic Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 9.33 F3 SERPINC1 TNF
2 virus receptor activity GO:0001618 9.13 CD209 HLA-DRB1 TFRC
3 cytokine activity GO:0005125 9.02 CD40LG IFNG IL10 IL6 TNF

Sources for Hemorrhagic Fever

3 CDC
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10 dbSNP
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16 ExPASy
18 FMA
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65 SNOMED-CT via HPO
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67 TGDB
68 Tocris
69 UMLS
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