MCID: HMR012
MIFTS: 58

Hemorrhagic Fever malady

Rare diseases category
Download this MalaCard

Summaries for Hemorrhagic Fever

About this section


Fully expand this MalaCard
MedlinePlus:33 Viral hemorrhagic fevers (vhfs) are a group of illnesses caused by four families of viruses. these include the ebola and marburg, lassa fever, and yellow fever viruses. vhfs have common features: they affect many organs, they damage the blood vessels, and they affect the body's ability to regulate itself. some vhfs cause mild disease, but some, like ebola or marburg, cause severe disease and death. vhfs are found around the world. specific diseases are usually limited to areas where the animals that carry them live. for example, lassa fever is limited to rural areas of west africa where rats and mice carry the virus. the risk for travelers is low, but you should avoid visiting areas where there are disease outbreaks. because there are no effective treatments for some of these viral infections, there is concern about their use in bioterrorism. centers for disease control and prevention

MalaCards based summary: Hemorrhagic Fever, also known as hemorrhagic fevers, viral, is related to dengue disease and rift valley fever. An important gene associated with Hemorrhagic Fever is CD40LG (CD40 ligand), and among its related pathways are Inflammatory Response Pathway and IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types. The compounds gamma globulin and d-galactosamine have been mentioned in the context of this disorder. Affiliated tissues include testes, endothelial and t cells, and related mouse phenotypes are endocrine/exocrine gland and liver/biliary system.

Wikipedia:65 The viral hemorrhagic (or haemorrhagic) fevers (VHFs) are a diverse group of animal and human illnesses... more...

Aliases & Classifications for Hemorrhagic Fever

About this section

Hemorrhagic Fever, Aliases & Descriptions:

Name: Hemorrhagic Fever 42 44
Hemorrhagic Fevers, Viral 62
 
Hemorrhagic Fevers 33


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Related Diseases for Hemorrhagic Fever

About this section

Diseases in the Hemorrhagic Fever family:

Viral Hemorrhagic Fever

Diseases related to Hemorrhagic Fever via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 198)
idRelated DiseaseScoreTop Affiliating Genes
1dengue disease31.3CD40LG, SLC17A5
2rift valley fever31.3MX1
3encephalitis31.2MX1
4cholecystitis31.2GPT
5lassa fever31.0GP2
6purpura31.0SERPINC1
7acute pancreatitis30.8GPT, SLC17A5, IL6, GP2
8hepatitis30.8SLC17A5, MX1, GPT, CD40LG
9acute liver failure30.6GPT, SLC17A5
10leishmaniasis30.6IFNG
11scrub typhus30.5CD40LG, GPT, SLC17A5
12pneumonia30.5IL6, TNF
13hemorrhagic disease30.4SERPINC1, F3
14malaria30.4TNF, TLR9, IFNG
15thrombocytopenia30.1ITGB3, SLC17A5, CD40LG, IL6, F3, SERPINC1
16hepatitis b30.1SLC17A5, MX1, GPT, IFNG
17septic shock30.0F3, SERPINC1, TNF, IL6
18vascular disease29.8F3, ITGB3, SERPINC1
19influenza29.8TLR9, TLR8, MX1, IFNG
20viral infectious disease28.5MX1, GP2, IL6, TLR9, TLR8, SLC17A5
21dengue hemorrhagic fever11.3
22crimean-congo hemorrhagic fever11.3
23hemorrhagic fever with renal syndrome11.2
24argentine hemorrhagic fever10.9
25ebola hemorrhagic fever10.9
26viral hemorrhagic fever10.8
27korean hemorrhagic fever10.8
28marburg hemorrhagic fever10.8
29bolivian hemorrhagic fever10.7
30omsk hemorrhagic fever10.7
31dengue shock syndrome10.7
32alkhurma hemorrhagic fever10.6
33venezuelan hemorrhagic fever10.6
34fascioliasis10.6SLC17A5
35schnitzler syndrome10.6CD40LG
36sagittal sinus thrombosis10.5SERPINC1
37endotheliitis10.5
38toxoplasmosis10.5CD40LG
39nephropathia epidemica10.5
40hantavirus pulmonary syndrome10.5
41pancreatitis10.5
42carotid artery thrombosis10.5F3
43pyridoxine deficiency10.4SLC17A5, GPT
44hepatitis e10.4CD40LG, GPT
45cryoglobulinemia10.4SLC17A5, CD40LG
46blood protein disease10.4CD40LG, SERPINC1
47obstructive jaundice10.4GPT, SLC17A5
48choledocholithiasis10.4GPT, SLC17A5
49lujo hemorrhagic fever10.4
50brazilian hemorrhagic fever10.4

Graphical network of the top 20 diseases related to Hemorrhagic Fever:



Diseases related to hemorrhagic fever

Symptoms for Hemorrhagic Fever

About this section

Drugs & Therapeutics for Hemorrhagic Fever

About this section

Drug clinical trials:

Search ClinicalTrials for Hemorrhagic Fever

Search NIH Clinical Center for Hemorrhagic Fever

Genetic Tests for Hemorrhagic Fever

About this section

Anatomical Context for Hemorrhagic Fever

About this section

MalaCards organs/tissues related to Hemorrhagic Fever:

32
Testes, Endothelial, T cells, Liver, Kidney, Monocytes, Pituitary, Heart, Pancreas, B cells, Skin, Bone marrow, Bone, Whole blood, Cerebellum, Lung, Myeloid, Nk cells, Neutrophil

Animal Models for Hemorrhagic Fever or affiliated genes

About this section

Publications for Hemorrhagic Fever

About this section

Articles related to Hemorrhagic Fever:

(show top 50)    (show all 1536)
idTitleAuthorsYear
1
Hemostatic derangement in dengue hemorrhagic fever. (24120237)
2014
2
Cytokine concentrations in pediatric patients with crimean-congo hemorrhagic Fever. (25361408)
2014
3
Role of cognitive parameters in dengue hemorrhagic fever and dengue shock syndrome. (24305068)
2013
4
Genetic characterization and molecular clock analyses of the Crimean-Congo hemorrhagic fever virus from human and ticks in India, 2010-2011. (23195573)
2013
5
Evaluation of Crimean-Congo hemorrhagic fever virus infection in children. (24107215)
2013
6
Ecology and geography of hemorrhagic fever with renal syndrome in Changsha, China. (23819824)
2013
7
Infection and propagation of Crimean-Congo hemorrhagic fever virus in embryonated chicken eggs. (23352881)
2013
8
Seroprevalence of Crimean Congo hemorrhagic fever virus in Ijara District, Kenya. (22925021)
2012
9
An antibody recognizing the apical domain of human transferrin receptor 1 efficiently inhibits the entry of all new world hemorrhagic Fever arenaviruses. (22278244)
2012
10
Acute pancreatitis in dengue hemorrhagic fever. (22451187)
2012
11
Effect of oral ribavirin treatment on the viral load and disease progression in Crimean-Congo hemorrhagic fever. (21106428)
2011
12
Experience with extrarenal manifestations of hemorrhagic fever with renal syndrome in a tertiary care hospital in South Korea. (21292889)
2011
13
Outbreak of Marburg hemorrhagic fever among miners in Kamwenge and Ibanda Districts, Uganda, 2007. (21987753)
2011
14
Assessing changes in vascular permeability in a hamster model of viral hemorrhagic fever. (20846417)
2010
15
Dengue hemorrhagic fever: the sensitivity and specificity of the world health organization definition for identification of severe cases of dengue in Thailand, 1994-2005. (20205587)
2010
16
Imported case of Marburg hemorrhagic fever - Colorado, 2008. (20019654)
2009
17
Modeling the spatial distribution of crimean-congo hemorrhagic fever outbreaks in Turkey. (18047397)
2007
18
Geographic potential for outbreaks of Marburg hemorrhagic fever. (16837700)
2006
19
Cytokine levels in Crimean-Congo hemorrhagic fever. (16765637)
2006
20
Pathogenesis of viral hemorrhagic fever. (15955687)
2005
21
Clinical observation of liver damages in epidemic hemorrhagic fever]. (15897149)
2005
22
Alkhumra virus infection, a new viral hemorrhagic fever in Saudi Arabia. (16038757)
2005
23
Economic impact of dengue fever/dengue hemorrhagic fever in Thailand at the family and population levels. (15964964)
2005
24
The correlation between coagulation test and albumin with antithrombin III in Dengue hemorrhagic fever. (15931699)
2004
25
Crimean-Congo hemorrhagic fever virus glycoprotein proteolytic processing by subtilase SKI-1. (12885882)
2003
26
Recombinant nucleoprotein-based enzyme-linked immunosorbent assay for detection of immunoglobulin G antibodies to Crimean-Congo hemorrhagic fever virus. (11980926)
2002
27
Outbreak of Ebola hemorrhagic fever, Uganda, August 2000-January 2001. (11428235)
2001
28
The dengue and dengue hemorrhagic fever epidemic in Puerto Rico, 1994-1995. (11425166)
2001
29
Hemorrhagic fever with renal syndrome: diagnostic problems with a known disease. (11526193)
2001
30
Epidemiological progresses of hemorrhagic fever with renal syndrome in China. (11593522)
1999
31
Determining the incidence of dengue hemorrhagic fever in Puerto Rico. (10730299)
1999
32
Gallbladder wall thickening in dengue hemorrhagic fever: an ultrasonographic study. (7673451)
1995
33
Antiviral treatment of Argentine hemorrhagic fever. (8141590)
1994
34
Dengue virus and endothelial cell: a related phenomenon to thrombocytopenia and granulocytopenia in dengue hemorrhagic fever. (7886587)
1993
35
Epidemiologic surveillance on the hemorrhagic fever with renal syndrome in China. (7908258)
1993
36
Effect of glucocorticoid hormones on the status of the hypothalamo-hypophyseal-adrenal system and endocrine function of the pancreas in patients with hemorrhagic fever with renal syndrome]. (1977953)
1990
37
Distribution of Crimean-Congo hemorrhagic fever viral antibody in Senegal: environmental and vectorial correlates. (2122750)
1990
38
Hemorrhagic fever with renal syndrome. (2647265)
1989
39
What is new and where are the problems in research on hemorrhagic fever with renal syndrome? (2573193)
1989
40
A clinical study of hemorrhagic fever with renal syndrome caused by Seoul virus infection. (2577257)
1989
41
Association of dengue hemorrhagic fever with the HLA system. (3498669)
1987
42
Virus-specific factors in experimental Argentine hemorrhagic fever in rhesus macaques. (3039054)
1987
43
Antibody to hemorrhagic fever with renal syndrome viruses (Hantaviruses) in the United States. (2891295)
1987
44
Dengue hemorrhagic fever--Puerto Rico. (3097497)
1986
45
Hemorrhagic fever with renal syndrome--a clinical perspective. (2867491)
1985
46
Correlation between endogenous interferon and the clinical evolution of patients with Argentine hemorrhagic fever. (4056485)
1985
47
Features of circulation of hemorrhagic fever with renal syndrome (HFRS) virus among small mammals in the European U.S.S.R. (6220688)
1983
48
Nosocomial outbreak of viral hemorrhagic fever caused by Crimean Hemorrhagic fever-Congo virus in Pakistan, January 1976. (7435795)
1980
49
Early recognition of severe dengue hemorrhagic fever. (632709)
1978
50
Detection of sporadic cases of dengue hemorrhagic fever. (5501443)
1970

Variations for Hemorrhagic Fever

About this section

Expression for genes affiliated with Hemorrhagic Fever

About this section
Expression patterns in normal tissues for genes affiliated with Hemorrhagic Fever

Search GEO for disease gene expression data for Hemorrhagic Fever.

Pathways for genes affiliated with Hemorrhagic Fever

About this section

Pathways related to Hemorrhagic Fever according to GeneCards/GeneDecks:

(show all 42)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9IFNG, CD40LG
2
Show member pathways
9.8IFNG, TNF
3
Show member pathways
9.8IFNG, TNF
49.8IL6, TNF
5
Show member pathways
Calcium signaling in the CD4+ TCR pathway37
9.5TNF, IFNG, CD40LG
69.4TLR9, TLR8
79.4IL6, IFNG, TNF
89.4IL6, IFNG, TNF
99.4IL6, IFNG, TNF
10
Show member pathways
Immune response MIF in innate immunity response60
9.4IL6, IFNG, TNF
119.4IL6, IFNG, TNF
129.4IL6, IFNG, TNF
13
Show member pathways
thioredoxin pathway37
9.4TNF, IFNG, IL6
14
Show member pathways
IL23-mediated signaling events37
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling37
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
9.4TNF, IFNG, IL6
159.4TNF, IFNG, IL6
169.4TNF, IFNG, IL6
17
Show member pathways
Serotonin Transporter Activity37
9.3ITGB3, TNF
18
Show member pathways
9.2CD40LG, TNF, TLR9
19
Show member pathways
9.2CD40LG, IL6, IFNG, TNF
20
Show member pathways
9.2TNF, IFNG, IL6, CD40LG
21
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
9.2TNF, IFNG, IL6, CD40LG
22
Show member pathways
9.2TNF, IFNG, IL6, CD40LG
239.1TLR8, TLR9, TNF
24
Show member pathways
9.1TNF, TLR9, TLR8
259.0TNF, IFNG, ITGB3
26
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy37
8.9IL6, ITGB3, TNF
278.9TNF, ITGB3, IL6
288.8IL6, IFNG, TNF, TLR9
298.8TLR9, TNF, IFNG, IL6
30
Show member pathways
8.8IL6, IFNG, TLR9, TLR8
31
Show member pathways
8.7TLR8, TLR9, TNF, IFNG
32
Show member pathways
8.7IL6, TNF, TLR9, TLR8
338.6ITGB3, TLR9, TLR8
34
Show member pathways
8.6TNF, IFNG, ITGB3, IL6
358.6CD40LG, IL6, IFNG, TNF, TLR9
36
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
8.4IL6, IFNG, TNF, TLR9, TLR8
378.4IL6, IFNG, TNF, TLR9, TLR8
38
Show member pathways
IL27-mediated signaling events37
8.4TLR8, TLR9, TNF, IFNG, IL6
39
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
8.4TLR8, TLR9, TNF, IFNG, IL6
40
Show member pathways
8.3MX1, IL6, IFNG, TNF, TLR9
41
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
8.2TLR8, TLR9, TNF, F3, IL6
42
Show member pathways
7.9TLR8, TLR9, TNF, ITGB3, IL6

Compounds for genes affiliated with Hemorrhagic Fever

About this section

Compounds related to Hemorrhagic Fever according to GeneCards/GeneDecks:

(show top 50)    (show all 177)
idCompoundScoreTop Affiliating Genes
1gamma globulin449.9IFNG, CD40LG, SLC17A5
2d-galactosamine449.9TNF, SLC17A5, GPT
3ximelagatran44 1110.7GPT, SERPINC1, F3
4vesnarinone449.7IL6, TNF, IFNG
5taurine chloramine449.7TNF, IFNG, IL6
6gabexate mesilate449.7SERPINC1, TNF, IL6
7ulinastatin449.7IL6, SERPINC1, TNF
8ppack449.7F3, SERPINC1, CD40LG
9mycophenolate mofetil44 50 1111.6TNF, IFNG, GPT, CD40LG
10nash449.6GPT, TNF, SLC17A5
11il-12449.6CD40LG, IL6, IFNG, TNF
12okt3449.6TNF, IFNG, CD40LG, IL6
13hepaplastin449.5F3, GPT, SERPINC1, SLC17A5
14pioglitazone28 44 50 1112.5IL6, SLC17A5, TNF, GPT
15hydroxychloroquine44 1110.5CD40LG, TNF, TLR9
16adalimumab44 50 1111.4IFNG, TNF, IL6
17dextran sulfate449.4CD40LG, F3, SERPINC1, IL6
18fenofibrate44 50 1111.4TNF, IL6, CD40LG, SLC17A5, GPT
19atorvastatin44 50 28 24 1113.4GPT, SLC17A5, IL6, CD40LG, TNF
20ivig449.3IFNG, CD40LG, IL6, GPT, TNF
21ifn-alpha449.3IFNG, IL6, GPT, MX1
22thalidomide44 50 61 1112.3IFNG, CD40LG, IL6, TNF
23prednisolone44 28 1111.3SLC17A5, IL6, IFNG, TNF, GPT
24ribavirin44 50 1111.3CD40LG, MX1, GPT, SLC17A5, IFNG
25pentoxifylline44 1110.2IL6, IFNG, F3, TNF
26aprotinin44 1110.2IL6, SLC17A5, F3, SERPINC1
27polyinosinic-polycytidylic acid449.2TLR9, TNF, IFNG, IL6
28pdtc449.2F3, IFNG, IL6, TNF
29rantes449.2CD40LG, MX1, IFNG, TLR9
30ccl344 2810.2TNF, IFNG, TLR9, IL6
312,5-oligoadenylate449.1MX1, IL6, IFNG, GPT, TNF
32tacrolimus44 50 1111.1F3, GPT, IFNG, TNF, SLC17A5
33n acetylcysteine449.1SERPINC1, TNF, SLC17A5, CD40LG, IL6, GPT
34cyclosporin a44 28 6111.0SLC17A5, CD40LG, IL6, IFNG, TNF, GPT
35tirofiban44 1110.0SERPINC1, F3, ITGB3, CD40LG
36abciximab44 1110.0ITGB3, CD40LG, SERPINC1, F3
37clopidogrel44 50 24 1112.0SERPINC1, F3, ITGB3, CD40LG
38imiquimod44 61 28 1111.9IFNG, MX1, TLR8, TNF, IL6
39rosiglitazone28 44 50 24 1112.9GPT, TNF, IL6, SLC17A5
40creatinine448.8F3, SERPINC1, IL6, CD40LG, SLC17A5, GPT
41simvastatin44 50 61 28 24 1113.8SLC17A5, IFNG, IL6, GPT, F3, TNF
42ristocetin448.7ITGB3, F3, SERPINC1
43actinomycin d448.7CD40LG, TNF, F3, IFNG, IL6
44neopterin448.6TNF, GPT, SLC17A5, CD40LG, MX1, IL6
45poly(i-c)448.3IL6, TLR8, MX1, IFNG, TNF, TLR9
46endotoxin448.2SLC17A5, F3, IFNG, IL6, CD40LG, TLR9
47vegf447.9ITGB3, IFNG, CD40LG, F3, SERPINC1, TNF
48fibrinogen447.8ITGB3, GPT, TNF, SLC17A5, CD40LG, SERPINC1
49alanine447.6ITGB3, GPT, SERPINC1, SLC17A5, CD40LG, MX1
50lipid447.5GPT, TNF, ITGB3, IL6, MX1, SLC17A5

GO Terms for genes affiliated with Hemorrhagic Fever

About this section

Cellular components related to Hemorrhagic Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endolysosome membraneGO:0360209.3TLR9, TLR8
2external side of plasma membraneGO:0098979.2CD40LG, IL6, IFNG, TNF
3extracellular spaceGO:0056158.4TNF, SERPINC1, F3, IFNG, IL6, CD40LG
4extracellular regionGO:0055767.8TLR9, GP2, TNF, SERPINC1, IFNG, IL6
5plasma membraneGO:0058867.3TNF, SERPINC1, F3, ITGB3, CD40LG, SLC17A5

Biological processes related to Hemorrhagic Fever according to GeneCards/GeneDecks:

(show all 40)
idNameGO IDScoreTop Affiliating Genes
1regulation of immunoglobulin secretionGO:05102310.2CD40LG, TNF
2neutrophil apoptotic processGO:00178110.2IFNG, IL6
3positive regulation of vitamin D biosynthetic processGO:06055710.2IFNG, TNF
4positive regulation of calcidiol 1-monooxygenase activityGO:06055910.2TNF, IFNG
5positive regulation of chemokine biosynthetic processGO:04508010.1IFNG, TNF
6cellular amino acid biosynthetic processGO:00865210.1TNF, GPT
7epithelial cell proliferation involved in salivary gland morphogenesisGO:06066410.1TNF, IL6
8defense response to protozoanGO:04283210.1IL6, IFNG
9positive regulation of membrane protein ectodomain proteolysisGO:05104410.1IFNG, TNF
10negative regulation of growth of symbiont in hostGO:04413010.1TNF, IFNG
11positive regulation of osteoclast differentiationGO:04567210.1TNF, IFNG
12positive regulation of interleukin-8 biosynthetic processGO:04541610.0TNF, TLR8
13protein import into nucleus, translocationGO:00006010.0TNF, IFNG
14positive regulation of interleukin-18 productionGO:0327419.9TLR9, TNF
15defense response to Gram-positive bacteriumGO:0508309.9TNF, IL6
16positive regulation of nitric oxide biosynthetic processGO:0454299.8TNF, IFNG, IL6
17positive regulation of interferon-alpha biosynthetic processGO:0453569.8TLR9, TLR8
18humoral immune responseGO:0069599.8TNF, IFNG, IL6
19positive regulation of interferon-beta biosynthetic processGO:0453599.8TLR8, TLR9
20extrinsic apoptotic signaling pathwayGO:0971919.8IFNG, TNF
21positive regulation of interferon-gamma biosynthetic processGO:0450789.8TLR8, TLR9
22positive regulation of NF-kappaB import into nucleusGO:0423469.7TLR9, TNF
23negative regulation of interleukin-6 productionGO:0327159.7TNF, TLR9
24defense response to Gram-negative bacteriumGO:0508299.7IL6, TLR9
25positive regulation of interleukin-12 productionGO:0327359.7CD40LG, IFNG, TLR9
26positive regulation of JUN kinase activityGO:0435079.7TLR9, TNF
27negative regulation of viral genome replicationGO:0450719.6TNF, MX1
28positive regulation of protein kinase B signalingGO:0518979.6TNF, F3, IL6
29positive regulation of chemokine productionGO:0327229.6IL6, TNF, TLR9
30positive regulation of interleukin-6 productionGO:0327559.5IL6, TNF, TLR9
31positive regulation of NF-kappaB transcription factor activityGO:0510929.5IL6, TNF, TLR9
32negative regulation of fat cell differentiationGO:0455999.5IL6, TNF
33cytokine-mediated signaling pathwayGO:0192219.4MX1, IL6, IFNG
34positive regulation of tumor necrosis factor productionGO:0327609.4TLR9, IFNG
35negative regulation of lipid storageGO:0108889.4IL6, ITGB3, TNF
36defense response to virusGO:0516079.3TLR8, IFNG, IL6, MX1
37response to virusGO:0096159.3TLR8, TNF, IFNG, MX1
38platelet activationGO:0301689.3CD40LG, IL6, ITGB3
39inflammatory responseGO:0069548.9TLR8, TLR9, TNF, IL6, CD40LG
40positive regulation of transcription from RNA polymerase II promoterGO:0459448.8IL6, IFNG, TNF, TLR9

Molecular functions related to Hemorrhagic Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor receptor bindingGO:0051649.8CD40LG, TNF
2cytokine activityGO:0051259.1CD40LG, IL6, IFNG, TNF
3protease bindingGO:0020209.0F3, SERPINC1, TNF

Products for genes affiliated with Hemorrhagic Fever

About this section
  • Antibodies
  • Proteins
  • Lysates

Sources for Hemorrhagic Fever

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet