Hemorrhagic Fever malady

MedlinePlus: Viral hemorrhagic fevers (vhfs) are a group of illnesses caused by four families of viruses. these include the ebola and marburg viruses and lassa fever virus. vhfs have common features: they affect many organs, they damage the blood vessels and they affect the body's ability to regulate itself. some vhfs cause mild disease, but some, like ebola or marburg, cause severe disease and death. vhfs are found around the world. specific diseases are usually limited to areas where the animals that carry them live. for example, lassa fever is limited to rural areas of west africa where rats and mice carry the virus. the risk for travelers is low, but you should avoid visiting areas where there are disease outbreaks. because there are no effective treatments for some of these viral infections, there is concern about their use in bioterrorism. centers for disease control and prevention²³

MalaCards: Hemorrhagic Fever, also known as hemorrhagic fevers, viral, is related to hemorrhagic fever with renal syndrome and crimean-congo hemorrhagic fever. An important gene associated with Hemorrhagic Fever is RNPC3 (RNA-binding region (RNP1, RRM) containing 3), and among its related pathways are Immune response Role of TLRs 3 and 4 in cell antiviral response- TICAM1-specific signaling pathways and Regulation of autophagy. The compounds cyclophosphamide and ivig have been mentioned in the context of this disorder. Affiliated tissues include heart, liver and pancreas, and related mouse phenotypes are endocrine/exocrine gland and respiratory system.

Wikipedia: The viral hemorrhagic (or haemorrhagic) fevers (VHFs) are a diverse group of animal and human illnesses...⁴⁴ more...

hemorrhagic fever 30 32 hemorrhagic fevers, viral 43

hemorrhagic fevers 23

Diseases related to hemorrhagic fever by text searches and GeneDecks gene sharing:

(show top 50)    (show all 905)

id	Related Disease	Score	Top Affiliating Genes
1	hemorrhagic fever with renal syndrome	35.2	VTN, VCAM1, UBASH3A, B2M, FRS3, CD40LG
2	crimean-congo hemorrhagic fever	34.1	VEGFA, PARVA, CHIT1, MX1, ISG20, IL6
3	dengue hemorrhagic fever	34.0	GC, SERPINC1, VEGFA, LPL, VDR, MYD88
4	argentine hemorrhagic fever	33.9	GP2, F8, TMBIM4
5	dengue disease	33.5	VCAM1, CD209, IGHV4-39, ICAM1, F3, TNF
6	ebola hemorrhagic fever	31.9	ISG15, IRF9, GP2, IFIT1, IFIT2, F5
7	hantavirus pulmonary syndrome	31.4	UBASH3A, F3, F2, TBK1
8	lassa fever	31.2	MBTPS1, GP2, IFNG, TMBIM4, DAG1, RNPC3
9	nephropathia epidemica	30.1	IL6, HLA-B, HLA-DRB1, TNF, CRP
10	dengue shock syndrome	30.0	UBL7, AVIL, IVNS1ABP, IL6, HLA-A, HLA-DRB1
11	hypopituitarism	28.8	INS, IL6, IGF1, CYP19A1, CRP, PRL
12	thrombocytopenia	27.5	SERPINC1, CHIT1, CFH, CD40LG, IVNS1ABP, ITGA2B
13	viral infectious disease	26.9	VTN, MYD88, MX1, LBR, B2M, CD209
14	nephropathy	25.0	VTN, VEGFA, LPL, VDR, VCAM1, MYD88
15	cryptococcosis	14.4	CD40LG, FCGR2A, IL10, IL6, IFNG, F3
16	spotted fever	14.3	CHKB, IL10, IGHV4-39, IFNG, F2, TNF
17	rift valley fever	14.3	MX1, IGHV4-39, IFNAR1, IFNG, RNPC3, PRNT
18	typhoid fever	14.3	IL1R1, GPT, IGHV4-39, IFNG, IFNGR1, F2
19	viral encephalitis	14.3	VEGFA, VCAM1, MX1, CD40LG, IL10, IL6
20	optic neuritis	14.3	CD40LG, IL10, IFNB1, ICAM1, HLA-A, HLA-B
21	mycobacterium avium complex disease	14.3	IL10, IL6, IFNG, IFNGR1, TNF
22	syphilis	14.3	B2M, CD209, CD40LG, IGHV4-39, F2, HLA-DRB1
23	aphthous stomatitis	14.2	VDR, IL10, IL6, IFNG, HLA-A, HLA-B
24	guillain-barre syndrome	14.2	CD40LG, FCGR2A, IL10, IFNG, HLA-DRB1, HLA-DRB4
25	cutaneous lupus erythematosus	14.2	MX1, CD40LG, IRF7, IL10, CCL27, IFNA1
26	infectious mononucleosis	14.2	B2M, CD40LG, IL10, IL6, GPT, IGHV4-39
27	alveolar echinococcosis	14.2	IL10, IFNG, HLA-A, HLA-B, HLA-DRB1, HLA-DRB5
28	poliomyelitis	14.2	CD40LG, FCGR2A, IL10, IL4, IGHV4-39, IFNG
29	typhus	14.2	CD40LG, GPT, IGHV4-39, F3, CRP, SLC17A5
30	waldenstrom macroglobulinemia	14.2	VEGFA, CD40LG, ITGA4, IL10, IL6, IFNG
31	collagen disease	14.2	VEGFA, IL10, IL6, IFNG, TNF, CTLA4
32	sympathetic ophthalmia	14.2	IL10, HLA-DRB1, TNF, LTA
33	african tick-bite fever	14.2	CD40LG, IL10, GPT, IFNG
34	psoriatic arthritis	14.2	IL10, IL6, TNF, LTA
35	eczema	14.2	LBR, CD40LG, IL10, IL10RA, IL4, IL6
36	echinococcosis	14.2	IVNS1ABP, IL10, IL4, IGHV4-39, IFNG, HLA-A
37	malaria	14.2	CD40LG, IRF1, FCGR2B, IL10, IL4, IFNAR1
38	pulmonary sarcoidosis	14.2	LBR, ITGA4, ITGAM, IFNG, ICAM1, TNF
39	peripheral arterial occlusive disease	14.2	VCAM1, CD40LG, IL6, GPT, F5, ICAM1
40	leukomalacia	14.1	VEGFA, IL1R1, IL6, TNF, SLC17A5
41	cytomegalovirus retinitis	14.1	IL10RA, IFNB1, IFNG, HLA-A, HLA-B, HLA-DRB1
42	plasmodium falciparum malaria	14.1	CHIT1, CD55, FCGR2A, IL10, IFNG, ICAM1
43	hepatic encephalopathy	14.1	GC, IL6, GPT, F2, ALB, TNF
44	mycobacterial infection	14.1	CD209, IL10, IL4, IL6, IFNG, IFNGR1
45	cystoid macular edema	14.1	VEGFA, IL10, IFNG, HLA-B
46	multiple sclerosis	14.1	IFNG, ICAM1, HLA-A, HLA-B, HLA-DRB1, HLA-DRB5
47	scrub typhus	14.1	CD40LG, GPT, F3, CRP, SLC17A5
48	cryoglobulinemia	14.1	VCAM1, MX1, CD81, CD40LG, IL10, IL4
49	alcoholic hepatitis	14.1	IL10, IL8, ICAM1, F2, TNF
50	takayasu's arteritis	14.1	SERPINC1, VCAM1, LBR, CD40LG, ITGA2B, ITGB3

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to hemorrhagic fever:

²²

MGI Mouse Phenotypes related to hemorrhagic fever:

²⁵ (show all 26)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	10.6	SPTBN1, CD40LG, IFNG, CTLA4, TLR3, TYR
2	respiratory system phenotype	MP:0005388	10.2	LPL, CD81, IVNS1ABP, ITGB3, FCGR2B, IKBKE
3	limbs/digits/tail phenotype	MP:0005371	9.8	DRD2, CREBBP, LTA, THBS1, STAT1, IL10
4	embryogenesis phenotype	MP:0005380	9.7	PRL, ADAR, SOCS3, TYR, CREBBP, SPTBN1
5	craniofacial phenotype	MP:0005382	9.5	PRKRA, NRP1, SPTBN1, PTPN11, TNFRSF19, TRAF6
6	adipose tissue phenotype	MP:0005375	9.4	TNFRSF1B, TNF, IGF1, LBR, IL1R1, INS
7	no phenotypic analysis	MP:0003012	9.2	IFNAR1, DRD2, PTPN11, DAG1, TYR, STAT1
8	vision/eye phenotype	MP:0005391	8.9	NRP1, PLG, LTA, TYR, TICAM1, THBS1
9	hematopoietic system phenotype	MP:0005397	8.9	IRF5, MYD88, UBASH3A, JAK1, ITGA2B, ITGAE
10	reproductive system phenotype	MP:0005389	8.8	THBS1, VEGFA, B2M, ITGA2B, ITGB1, TGFB1
11	integument phenotype	MP:0010771	8.6	LBR, ITGB1, ITGB3, IRF1, IRF9, IL1R1
12	skeleton phenotype	MP:0005390	8.6	IFNB1, IFNGR1, TNFRSF1B, DRD2, PTPN11, DARC
13	renal/urinary system phenotype	MP:0005367	8.6	DRD2, TNFRSF1B, THBS1, IFNGR1, MYD88, PARVA
14	digestive/alimentary phenotype	MP:0005381	8.5	TICAM1, THBS1, TGFB1, TFRC, STAT1, SOCS1
15	muscle phenotype	MP:0005369	8.4	ITGB1, ITGB3, AR, IL10, IL6, IL1R1
16	normal phenotype	MP:0002873	8.4	EFEMP2, IFNG, SOCS3, JAK2, SOCS1, STAB2
17	liver/biliary system phenotype	MP:0005370	8.1	FCGR2B, IL1R1, IL6, MBTPS1, IFNG, IFNGR1
18	behavior/neurological phenotype	MP:0005386	8.1	SLC17A5, ITGB1, CD55, CD81, JAK1, AVIL
19	immune system phenotype	MP:0005387	8.0	IRAK4, CREBBP, PLG, EIF2AK2, TYK2, TYR
20	nervous system phenotype	MP:0003631	7.8	PRKAR1B, PRL, STAT1, PLG, TAP1, F2
21	tumorigenesis	MP:0002006	7.7	IRF1, AR, IL10, IL6, MC1R, MAPK14
22	growth/size phenotype	MP:0005378	6.3	TFRC, CYP19A1, LTA, SPTBN1, NRP1, ADAR
23	cellular phenotype	MP:0005384	6.0	VEGFA, VDR, VCAM1, MYD88, CKM, UBASH3A
24	mortality/aging	MP:0010768	6.0	ITGA4, ITGB3, IRF1, AR, FCGR2A, FCGR2B
25	cardiovascular system phenotype	MP:0005385	5.7	CYP19A1, IFNAR1, IGF1, MAPK14, FADD, IL6
26	homeostasis/metabolism phenotype	MP:0005376	4.2	VCAM1, MYD88, PARVA, CKM, LBR, B2M

Articles related to hemorrhagic fever:

(show top 50)    (show all 82)

id	Title	Authors	Year	Affiliating Genes
1	HLA-associated hemorrhagic fever with renal syndrome disease progression in slovenian patients. (21775516)	Korva M.... Avsic-Zupanc T.	2011	HLA-B
2	Expression of VLA-4 molecule in PBMC from patients wi th hemorrhagic fever with renal syndrome. (21298552)	Xie M.... Lv S.	2011	ITGA4, ITGB1
3	DC-SIGN (CD209) Promoter -336 A/G polymorphism is ass ociated with dengue hemorrhagic fever and correlated to DC-SIGN expression and immune augmentation. (21245921)	Wang L.... Yang K.D.	2011	CD209
4	Evaluation of the association of serum levels of hyal uronic acid, sICAM-1, sVCAM-1, and VEGF-A with mortality and prognosis in patie nts with Crimean-Congo hemorrhagic fever. (20005156)	Ozturk B.... Tuzun H.	2010	VEGFA, SLC17A5
5	Agranulocytosis in dengue hemorrhagic fever: a neglec ted condition. (20462096)	Insiripong S.	2010	CSF3
6	Elevated sICAM-1 levels in patients with hemorrhagic fever with renal syndrome caused by Hantaan virus. (20725844)	Han Q.... Li N.	2010	ICAM1
7	Dengue hemorrhagic fever is associated with polymorph isms in JAK1. (20588308)	Silva L.K.... Teixeira M.G.	2010	JAK2, AR, ICAM1
8	Susceptible and protective HLA class 1 alleles agains t dengue fever and dengue hemorrhagic fever patients in a Malaysian population. (20927388)	Appanna R.... Sekaran S.D.	2010	HLA-A, HLA-B
9	Coagulopathy parameters in patients with Crimean-Cong o hemorrhagic fever and its relation with mortality. (20486197)	Onguru P.... Ozet G.	2010	F2, SERPINC1
10	Increased serum ferritin levels in patients with Crim ean-Congo hemorrhagic fever: can it be a new severity criterion? (19487150)	Barut S.... Erkorkmaz U.	2010	GPT
11	Toll-like receptor 8 and 9 polymorphisms in Crimean-C ongo hemorrhagic fever. (20674764)	Engin A.... Bakir M.	2010	TLR8, TLR9
12	Combination of CTLA-4 and TGFbeta1 gene polymorphisms associated with dengue hemorrhagic fever and virus load in a dengue-2 outbreak. (19269255)	Chen R.F.... Yang K.D.	2009	TGFB1, CTLA4
13	Differential expression of aldolase, alpha tubulin and thioredoxin peroxidase in peripheral blood mononuclear cells from dengue fever and dengue hemorrhagic fever patients. (19323035)	Thayan R.... Devi S.	2009	PRDX4, TUBA1B, ABCC11
14	Clinical characteristics, risk factors, and outcomes in adults experiencing dengue hemorrhagic fever complicated with acute renal failure. (19346394)	Lee I.K.... Yang K.D.	2009	F2, ALB
15	An outbreak of Crimean-Congo hemorrhagic fever in wes tern Anatolia, Turkey. (19409826)	Ertugrul B.... Sakarya S.	2009	GPT
16	Two Crimean-Congo hemorrhagic fever cases without hi story of tick contact from Ankara region (20084924)	Kaya KiliAs E.... DemirAPz A.P.	2009	F2
17	Serum chitotriosidase enzyme activity in patients wit h Crimean-Congo hemorrhagic fever. (19883210)	Kurt Y.G.... Erbil M.K.	2009	CHIT1
18	Application of flow microbeads assay in detection of specific antibodies and cytokines in serum from patients with hemorrhagic fever with renal syndrome. (19257990)	Zhang J.... Jin B.Q.	2009	TNF, IL6, CD40LG
19	High serum levels of neopterin in patients with Crime an-Congo hemorrhagic fever and its relation with mortality. (18420276)	Onguru P.... Cevik M.A.	2008	IFNG
20	Peripheral blood natural killer cells in Crimean-Cong o hemorrhagic fever. (18434247)	Yilmaz M.... Koksal I.	2008	F3
21	Receptor determinants of zoonotic transmission of New World hemorrhagic fever arenaviruses. (18268337)	Radoshitzky S.R.... Farzan M.	2008	TFRC
22	High risk of hypopituitarism in patients who recovered from hemorrhagic fever with renal syndrome. (18430769)	Stojanovic M.... Popovic V.	2008	IGF1, PRL
23	Puumala hantavirus viremia diagnosed by real-time reverse transcriptase PCR using samples from patients with hemorrhagic fever and renal syndrome. (17537944)	Evander M.... Allard A.	2007	CD40LG
24	Detection of circulating antigen with a MAb-based sandwich-ELISA and its comparison with specific IgM detection in sera of patients with hemorrhagic fever with renal syndrome. (17316085)	Wang C.Y.... Zhu C.B.	2007	CD40LG
25	Crimean-Congo hemorrhagic fever virus glycoprotein processing by the endoprotease SKI-1/S1P is critical for virus infectivity. (17898072)	Bergeron E.... Nichol S.T.	2007	MBTPS1
26	Chest radiographic presentation in patients with dengue hemorrhagic Fever. (17690401)	Wang C.C.... Lin M.C.	2007	ALB, F3
27	Crimean-Congo hemorrhagic fever. (17367225)	Mardani M.... Keshtkar-Jahromi M.	2007	F2, F3
28	Immunopathogenesis of dengue hemorrhagic fever and shock syndrome: role of TAP and HPA gene polymorphism. (18191725)	Soundravally R.... Hoti S.L.	2007	ITGB3, TAP1
29	Levels of soluble vascular cell adhesion molecule-1 and soluble intercellular adhesion molecule-2 in plasma of patients with hemorrhagic fever with renal syndrome, and significance of the changes in level. (16987074)	Qi B.T.... Xie M.	2006	VCAM1, ICAM2
30	Evaluation of serum levels of interleukin (IL)-6, IL-10, and tumor necrosis factor-alpha in patients with Crimean-Congo hemorrhagic fever. (16518755)	Ergonul O.... Dokuzoguz B.	2006	TNF, IL6
31	Clinical observation of liver damages in epidemic hemorrhagic fever (15897149)	Tang Z.Y.... Li S.H.	2005	ALB, GPT
32	Rehabilitation therapy of convalescents after hemorrhagic fever with renal syndrome in outpatient clinic (15108430)	Pimenov L.T.... Vasil'ev M.I.u.	2004	B2M
33	The correlation between coagulation test and albumin with antithrombin III in Dengue hemorrhagic fever. (15931699)	Jong J.B.... Nelwan R.H.	2004	SERPINC1
34	Human MxA protein inhibits the replication of Crimean-Congo hemorrhagic fever virus. (15047845)	Andersson I.... Mirazimi A.	2004	MX1
35	Using recombinant antigens of Hantavirus to study th e kinetics of serum IgA, IgG, IgM antibodies in the acute-phase of hemorrhagic fever renal syndrome (15340571)	Meng X.S.... Li D.X.	2003	CD40LG
36	Clinical presentations of dengue hemorrhagic fever in infants compared to children. (14700166)	Kalayanarooj S.... Nimmannitya S.	2003	F2
37	Hemorrhagic fever with renal syndrome: imported or native disease in the Zadar region (15011474)	Dzelalija B.... Avsic-Zupanc T.	2003	GPT
38	High circulating levels of the dengue virus nonstructural protein NS1 early in dengue illness correlate with the development of dengue hemorrhagic fever. (12355369)	Libraty D.H.... Rothman A.L.	2002	PTPN11
39	Clinicofunctional characteristics of the heart in hemorrhagic fever with renal syndrome (12471834)	Pimenov L.T.... Eshmakov S.V.	2002	GPT
40	Clinico-diagnostic evaluation of changes in ATPase a ctivity, lipid peroxidation and stability of red cell membranes in patients suf fering from hemorrhagic fever with renal syndrome (11270949)	Ibragimova L.A.... Fazlyeva R.M.	2000	DNAH8
41	A comparison of the pattern of liver involvement in dengue hemorrhagic fever with classic dengue fever. (11127322)	Wahid S.F.... Ali R.A.	2000	CCL27
42	Cytokine cascade in dengue hemorrhagic fever: implications for pathogenesis. (10865168)	Chaturvedi U.C.... Mustafa A.S.	2000	HCFC1
43	Functional loading tests in nephropathy examination in patients recovering from hemorrhagic fever with renal syndrome (10626329)	Pimenov L.T.... Kustarnikov G.K.	1999	B2M
44	The first reported outbreak of dengue hemorrhagic fever in Irian Jaya, Indonesia. (9242317)	Richards A.L.... Punjabi N.	1997	CD40LG
45	Increased production of nitric oxide in patients with hemorrhagic fever with renal syndrome--relation to arterial hypotension and tumor necrosis factor. (8923042)	Linderholm M.... TAornvik A.	1996	TNFRSF1B
46	Serum levels of tumor necrosis factor-alpha, interleukin-1, and interleukin-6 in hemorrhagic fever with renal syndrome. (8825292)	Krakauer T.... Krakauer H.	1995	TNF, IL6
47	Serum levels of alpha and gamma interferons in hemorrhagic fever with renal syndrome. (7848512)	Krakauer T.... Krakauer H.	1994	IFNG
48	Characteristics of immunocomplex in autopsy tissues o f hemorrhagic fever with renal syndrome. (7956485)	Liu Y.F.... Liu Y.Y.	1994	CD40LG
49	Prothrombin time and partial thromboplastin time as a predictor of bleeding in patients with dengue hemorrhagic fever. (7886557)	Chua M.N.... Laberiza F.	1993	F2, F3
50	Antibodies against dengue viral proteins in primary and secondary dengue hemorrhagic fever. (2063952)	Churdboonchart V.... Sirinavin S.	1991	PTPN11

Genes related to hemorrhagic fever according to GeneCards:

(show top 50)    (show all 173)

id	Symbol	Description	Score	GeneCards Section Context
1	RNPC3	RNA-binding region (RNP1, RRM) containing 3	11.0	Publications
2	CD40LG	CD40 ligand	11.0	Publications
3	TMBIM4	transmembrane BAX inhibitor motif containing 4	11.0
4	GPT	glutamic-pyruvate transaminase (alanine aminotransferase)	11.0	Publications
5	SLC17A5	solute carrier family 17 (anion/sugar transporter), member 5	11.0	Publications
6	IL6	interleukin 6 (interferon, beta 2)	11.0	Publications
7	TNF	tumor necrosis factor	11.0	Publications
8	IGHV4-39	immunoglobulin heavy variable 4-39	11.0
9	PRNT	prion protein (testis specific)	11.0
10	EHF	ets homologous factor	11.0
11	MX1	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)	11.0	Functions, Publications
12	CD209	CD209 molecule	11.0	UniProt Related, Publications
13	MBTPS1	membrane-bound transcription factor peptidase, site 1	11.0	Publications
14	IVNS1ABP	influenza virus NS1A binding protein	11.0
15	ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	11.0	Publications
16	LTA	lymphotoxin alpha (TNF superfamily, member 1)	11.0
17	PTPN11	protein tyrosine phosphatase, non-receptor type 11	11.0	Publications
18	F3	coagulation factor III (thromboplastin, tissue factor)	11.0	Publications
19	ICAM1	intercellular adhesion molecule 1	11.0	Publications
20	HLA-DRB1	major histocompatibility complex, class II, DR beta 1	11.0	Publications
21	HLA-B	major histocompatibility complex, class I, B	11.0	Publications
22	F2	coagulation factor II (thrombin)	11.0	Publications
23	IL10	interleukin 10	11.0	Publications
24	IFNG	interferon, gamma	11.0	Publications
25	VEGFA	vascular endothelial growth factor A	11.0	Publications
26	IFNE	interferon, epsilon	11.0	Publications
27	IFNA14	interferon, alpha 14	11.0	Publications
28	IFNK	interferon, kappa	11.0	Publications
29	IFNA13	interferon, alpha 13	11.0	Publications
30	IFNA4	interferon, alpha 4	11.0	Publications
31	IFNA8	interferon, alpha 8	11.0	Publications
32	IFNA16	interferon, alpha 16	11.0	Publications
33	IFNA5	interferon, alpha 5	11.0	Publications
34	IFNA6	interferon, alpha 6	11.0	Publications
35	IFNA10	interferon, alpha 10	11.0	Publications
36	IFNW1	interferon, omega 1	11.0	Publications
37	UBL7	ubiquitin-like 7 (bone marrow stromal cell-derived)	11.0
38	IFNA21	interferon, alpha 21	11.0	Publications
39	RNF31	ring finger protein 31	11.0	Publications
40	SAP30L	SAP30-like	11.0	Publications
41	RARRES3	retinoic acid receptor responder (tazarotene induced) 3	11.0	Publications
42	IFNA17	interferon, alpha 17	11.0	Publications
43	PRKRIR	protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)	11.0	Publications
44	PRKRA	protein kinase, interferon-inducible double stranded RNA dependent activator	11.0	Publications
45	OASL	2'-5'-oligoadenylate synthetase-like	11.0	Publications
46	CLEC4C	C-type lectin domain family 4, member C	11.0	Publications
47	EFEMP2	EGF containing fibulin-like extracellular matrix protein 2	11.0	Publications
48	TRAM1	translocation associated membrane protein 1	11.0	Publications
49	TLR8	toll-like receptor 8	11.0	Publications
50	ICAM2	intercellular adhesion molecule 2	11.0	Publications

Pathways related to hemorrhagic fever according to GeneDecks:

(show top 50)    (show all 184)

id	Pathway	Score	Top Affiliating Genes
1	Immune response Role of TLRs 3 and 4 in cell antiviral response- TICAM1-specific signaling pathways10	11.2	IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA21
2	Regulation of autophagy20	11.0	INS, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17
3	all-trans-Retinoic Acid Mediated Apoptosis36	11.0	IL6, FADD, IFNA10, IFNA13, IFNA14, IFNA16
4	Natural killer cell mediated cytotoxicity20	10.9	IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17
5	Immune response IFN gamma signaling pathway10	10.7	JAK2, IFNG, IFNGR2, EIF2AK2, STAT1, SOCS1
6	Th1 Differentiation37	10.7	JAK1, JAK2, IL10, IFNG, IFNGR1, IFNGR2
7	Immune response_Bacterial infections in normal airways41	10.6	MYD88, JAK1, IRAK4, IRF1, IL1R1, IFNG
8	Innate Immune System38	10.6	B2M, FADD, IKBKE, IFNA1, IFNA10, IFNA13
9	Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response10	10.6	MYD88, IRAK4, IL6, IFNB1, TRAF6, TLR7
10	Cytokine Network36	10.6	IL10, IL4, IL6, IL8, IFNA1, IFNA10
11	Interferon Pathway36	10.5	JAK1, JAK2, IL6, MAPK14, IFNA1, IFNA10
12	Immune response_TLR3 and TLR4 induce TICAM1-specific signaling pathway41	10.5	IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17
13	Malaria20	10.5	VCAM1, MYD88, CD81, CD40LG, IL10, IL6
14	Bacterial infections in CF airways41	10.4	MYD88, IRAK4, IRF1, IL1R1, TIRAP
15	Toll-Like Receptor Signaling Pathways37	10.4	MYD88, IRAK4, IRF7, IL6, MAPK14, IKBKE
16	TRAF Pathway36	10.4	MYD88, IRAK4, IL1R1, FADD, MAPK14, IKBKE
17	Autoimmune thyroid disease20	10.3	CD40LG, IL10, IL4, IFNA1, IFNA10, IFNA13
18	THC Differentiation Pathway36	10.3	IL10, IL10RA, IL4, IFNAR1, IFNAR2, IFNG
19	Chagas disease (American trypanosomiasis)20	10.3	MYD88, IRAK4, IL10, IL6, IL8, FADD
20	iNOS Signaling36	10.2	MYD88, JAK1, JAK2, IRAK4, IRF1, MAPK14
21	Toll-like receptor signaling pathway20	10.2	MYD88, IRAK4, IRF5, IRF7, IL6, IL8
22	Immune response_IFN gamma signaling pathway41	10.2	JAK1, JAK2, IRF1, IRF9, MAPK14, IFNG
23	Toll-Like Receptors Pathway36	10.2	MYD88, IRAK4, IRF7, MAPK14, IKBKE, TRAF6
24	Pertussis20	10.2	MYD88, ITGAM, ITGB1, IRAK4, IRF1, IL10
25	Allograft rejection20	10.1	CD40LG, IL10, IL4, IFNG, HLA-A, HLA-B
26	NF-KappaB (p50-p65) Pathway36	10.1	MYD88, IRAK4, IL1R1, IL1R2, IL6, FADD
27	RIG-I-like receptor signaling pathway20	10.1	ISG15, IRF7, FADD, IKBKE, IFNA10, IFNA13
28	NF-KappaB Family Pathway36	10.0	MYD88, IRAK4, IL1R1, IL1R2, IL6, FADD
29	Jak-STAT signaling pathway20	10.0	JAK1, JAK2, IRF9, IL10, IL10RA, IL4
30	Immune response_TLR signaling pathways41	10.0	MYD88, IRAK4, IL4, IL6, IL8, IFNB1
31	Cytosolic DNA-sensing pathway20	10.0	IRF7, IL6, IKBKE, IFNA1, IFNA10, IFNA13
32	Toxoplasmosis20	9.9	MYD88, JAK1, JAK2, CD40LG, ITGB1, IRAK4
33	NF-kappaB Signaling3	9.9	MYD88, IRAK4, IRF1, IRF5, IRF7, IKBKE
34	Immune response IL-1 signaling pathway10	9.8	MYD88, IRAK4, IRF1, IL1R1, IL6, IL8
35	Cytokine-cytokine receptor interaction20	9.8	VEGFA, CD40LG, IL10, IL10RA, IL1R1, IL1R2
36	Osteoclast differentiation20	9.8	JAK1, ITGB3, IRF9, FCGR2A, FCGR2B, IL1R1
37	Tuberculosis20	9.7	VDR, MYD88, JAK1, JAK2, CD209, ITGAM
38	Tec Kinases Signaling36	9.7	MYD88, JAK1, JAK2, ITGA2B, ITGA4, ITGAE
39	Immune response IFN alpha/beta signaling pathway10	9.6	JAK1, ISG15, IRF1, IRF9, IFIT2, IFNA1
40	Immune response_IL-1 signaling pathway41	9.6	MYD88, IRAK4, IRF1, IL1R1, IL6, IL8
41	Immune response_IFN alpha/beta signaling pathway41	9.6	JAK1, ISG15, IRF1, IRF9, IFIT2, IFNA1
42	Leishmaniasis20	9.5	MYD88, JAK1, JAK2, ITGA4, ITGAM, ITGB1
43	JAK-STAT Pathway36	9.5	JAK1, JAK2, IL10, IL10RA, IL1R1, IL4
44	Hematopoietic cell lineage20	9.4	CD55, ITGA2B, ITGA4, ITGAM, ITGB3, IL1R1
45	Measles20	9.3	MYD88, MX1, JAK1, JAK2, CD209, IRAK4
46	Phagosome20	9.1	CD209, ITGAM, ITGB1, ITGB3, FCGR2A, FCGR2B
47	Hepatitis C20	8.9	JAK1, CD81, IRF1, IRF7, IRF9, IL8
48	Influenza A20	8.3	MYD88, MX1, JAK1, JAK2, IVNS1ABP, IRAK4
49	Immune System38	INF	VCAM1, MX1, JAK1, CD81, ISG20, IRF1
50	Cell adhesion molecules (CAMs)20	INF	ITGA4, ITGAM, ITGB1, ICAM2, , HLA-DOB

Compounds related to hemorrhagic fever according to GeneDecks:

(show top 50)    (show all 369)

id	Compound	Score	Top Affiliating Genes
1	cyclophosphamide32 34 9 9	13.6	ITGA4, F8
2	ivig32	10.4	FCGR2B, IFNB1, F8, CRP, LTA
3	pentoxifylline32 9 9	12.4	VCAM1, LBR, ITGA4, ITGAM, IL10, IL1R1
4	atorvastatin32 34 9 18 9	14.3	VEGFA, LPL, VCAM1, CHKB, CD40LG, CD55
5	glucose32	10.3	CKM, IFNA2, TUBA1B, PLG, PRDX4, SOCS1
6	lipoteichoic acid32	10.2	MYD88, IL10, IL1R1, IL6, IL8, MAPK14
7	pge232	10.2	VTN, VCAM1, IRF1, AR, IL1R1, CCL27
8	infliximab32 9 9	12.1	VEGFA, LBR, ITGA4, IL10, IL1R1, IL4
9	rituximab32 34 9 9	13.1	CD40LG, CD55, FCGR2A, FCGR2B, IL10, IL1R1
10	ly29400232	9.9	VTN, VEGFA, ITGAM, FCGR2A, IL10, IL4
11	il 1032	9.8	VDR, IL10, IL10RA, IL1R1, IL4, IL6
12	prednisolone32 9 9	11.8	VCAM1, CHKB, ITGAM, FCGR2A, IL10, IL1R1
13	sb 20358032 42	10.8	VEGFA, VDR, VCAM1, ITGAM, ITGB1, IRF1
14	thalidomide32 42 9 9	12.8	VTN, VEGFA, B2M, CD40LG, IL10, IL6
15	n acetylcysteine32	9.7	SERPINC1, VCAM1, JAK1, JAK2, ITGAM, AR
16	okt332	9.7	VCAM1, LBR, CD40LG, IL10, IL6, ICAM1
17	ifn-alpha32	9.7	MX1, JAK1, IRF1, IRF7, IRF9, IL10
18	rosiglitazone32 9 18 9	12.7	LPL, VCAM1, JAK2, INS, IL1R1, IL4
19	imiquimod32 42 9 9	12.7	MX1, IL10, IL6, IL8, IFNA1, IFNA2
20	aspartate32	9.6	VTN, GC, VDR, CHKB, B2M, CD40LG
21	estrogen32	9.6	GC, SERPINC1, LPL, VDR, CHKB, ITGB3
22	thyroxine32 18	10.5	GC, LPL, VDR, CHKB, B2M, CD40LG
23	polyethylene glycol32	9.4	VTN, SERPINC1, CHKB, IFNA2, F8, TFRC
24	fibrinogen32	9.3	VTN, GC, SERPINC1, VCAM1, CHIT1, CHKB
25	calcitriol32 42 9 18 9	13.3	GC, VDR, B2M, ITGAM, ITGB1, AR
26	neopterin32	9.2	CHIT1, CHKB, MX1, LBR, B2M, CD40LG
27	poly(i-c)32	9.0	VCAM1, MX1, IRF1, IRF7, IL4, IL6
28	heparin32 9 18 9	11.9	VTN, LPL, CHKB, LBR, CFH, CD55
29	chloroquine32 34 9 9	11.9	VTN, SERPINC1, B2M, ITGAM, IL10, IL1R1
30	tacrolimus32 34 9 9	11.9	VTN, VDR, CHKB, CFH, ITGA4, INS
31	lactate32	8.8	VTN, LPL, VCAM1, CKM, CHKB, B2M
32	testosterone32 9 18 9	11.6	GC, SERPINC1, LPL, VDR, VCAM1, CHKB
33	actinomycin d32	8.6	VEGFA, VDR, JAK2, CD40LG, CD55, IRF1
34	creatinine32	8.6	GC, SERPINC1, VDR, CKM, B2M, CD40LG
35	nitric oxide32 9 18 9	11.5	VCAM1, MYD88, CKM, CHKB, LBR, JAK1
36	vitamin d32	8.5	GC, LPL, VDR, CHKB, LBR, B2M
37	adenylate32	8.4	GC, SERPINC1, LPL, VDR, VCAM1, CKM
38	genistein32 9 18 9	11.3	VEGFA, LPL, VDR, VCAM1, LBR, B2M
39	cyclosporin a32 42	9.3	LPL, VDR, CHKB, LBR, B2M, CFH
40	cysteine32	8.2	VTN, VDR, CKM, CHKB, LBR, CFH
41	vegf32	8.1	VTN, SERPINC1, VCAM1, CHKB, JAK2, CD40LG
42	thymidine32 18	9.0	VDR, CHKB, LBR, B2M, JAK1, JAK2
43	arginine32	7.9	VTN, SERPINC1, VDR, CKM, CHKB, LBR
44	alanine32	7.6	VTN, SERPINC1, VDR, VCAM1, CHKB, MX1
45	serine32	6.5	VTN, GC, SERPINC1, VDR, VCAM1, MYD88
46	cycloheximide32	6.3	VTN, VEGFA, LPL, VDR, MX1, LBR
47	polysaccharide32	INF	VTN, SERPINC1, LPL, VCAM1, CHIT1, CHKB
48	phosphatidylinositol32	INF	VTN, VCAM1, MYD88, JAK1, JAK2, CD81
49	tyrosine32	INF	VTN, VEGFA, VCAM1, MYD88, LBR, CFH
50	rantes32	INF	VCAM1, MYD88, MX1, LBR, CD209, CD40LG

Cellular components related to hemorrhagic fever according to GeneDecks:

(show all 14)

id	Name	GO ID	Score	Top Affiliating Genes
1	endolysosome membrane	GO:036020	10.5	TLR9, TLR3, TLR7, TLR8
2	ER to Golgi transport vesicle membrane	GO:012507	10.4	HLA-DRB5, HLA-DRB4, HLA-B, HLA-A, B2M, HLA-DRB1
3	integrin complex	GO:008305	10.4	ITGB3, ITGAE, ITGA2B, ITGA4, ITGAM, ITGB1
4	endosome membrane	GO:010008	10.2	TLR7, MYD88, TICAM1, TLR9, TLR3, TBK1
5	MHC class II protein complex	GO:042613	10.2	HLA-DRB5, HLA-DRB4, HLA-DRB1, HLA-DOB
6	integral to lumenal side of endoplasmic reticulum membrane	GO:071556	10.1	HLA-B, HLA-DRB1, HLA-DRB4, HLA-DRB5, HLA-A
7	external side of plasma membrane	GO:009897	9.8	ITGB1, ITGAE, ITGA4, ITGA2B, CD40LG, B2M
8	cell surface	GO:009986	9.7	TGFB1, VEGFA, LPL, VCAM1, CD93, CD55
9	platelet alpha granule lumen	GO:031093	9.3	THBS1, PLG, ALB, TGFB1, F5, IGF1
10	extracellular space	GO:005615	8.0	GC, IL6, IL8, CCL27, IGF1, IFNA10
11	cytosol	GO:005829	7.7	PARVA, VDR, GC, IRF5, MYD88, MAPK14
12	extracellular region	GO:005576	7.5	VTN, IL8, CCL27, GP2, IGF1, IFNA10
13	integral to plasma membrane	GO:005887	INF	TLR3, HLA-DRB1, HLA-DRB4, TFRC, ICAM1, GUCY2D
14	plasma membrane	GO:005886	INF	IFNGR2, F8, F5, ICAM1, ICAM2,

Biological processes related to hemorrhagic fever according to GeneDecks:

(show top 50)    (show all 79)

id	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of growth of symbiont in host	GO:044130	11.0	LTA, MYD88, TIRAP, TNF, IFNG, IL10
2	regulation of type I interferon-mediated signaling pathway	GO:060338	10.8	JAK1, SOCS3, SOCS1, STAT1, STAT2, TYK2
3	defense response to virus	GO:051607	10.8	RNASEL, FADD, IFNB1, IL6, IRF1, IFNG
4	positive regulation of interleukin-6 production	GO:032755	10.8	IL6, TNF, MYD88, TLR3, TLR7, TLR9
5	positive regulation of interferon-beta biosynthetic process	GO:045359	10.8	TLR9, TLR8, TLR3, TBK1, TLR7, TICAM1
6	positive regulation of chemokine biosynthetic process	GO:045080	10.8	IL4, TNF, TLR3, TICAM1, MYD88, IFNG
7	regulation of interferon-gamma-mediated signaling pathway	GO:060334	10.7	PTPN11, IFNGR2, JAK2, JAK1, IFNG, IFNGR1
8	positive regulation of tumor necrosis factor production	GO:032760	10.7	TIRAP, TICAM1, MYD88, JAK2, FADD, IFNG
9	I-kappaB kinase/NF-kappaB cascade	GO:007249	10.7	IRF1, TBK1, TLR3, TLR8, TIRAP, TRAF6
10	positive regulation of interferon-alpha biosynthetic process	GO:045356	10.7	TLR7, TLR8, TLR3, TLR9
11	negative regulation of viral genome replication	GO:045071	10.6	MX1, IFIT1, IFNB1, TNF, OAS1, OASL
12	leukocyte cell-cell adhesion	GO:007159	10.6	ITGB1, CD40LG, CD209, VCAM1, ICAM1, ITGA4
13	positive regulation of smooth muscle cell proliferation	GO:048661	10.6	TNF, STAT1, MYD88, IGF1, IRAK4, IL6
14	defense response to Gram-positive bacterium	GO:050830	10.6	TIRAP, IL6, TBK1, LTA, TNF, MYD88
15	JAK-STAT cascade	GO:007259	10.6	JAK2, IFNAR2, STAT2, STAT1, SOCS1, SOCS3
16	detection of bacterium	GO:016045	10.5	HLA-DRB1, HLA-B, HLA-A, HLA-DRB4, HLA-DRB5
17	positive regulation of chemokine production	GO:032722	10.5	TNF, IL6, TLR3, TLR7, TLR9
18	cellular response to mechanical stimulus	GO:071260	10.5	TLR8, FADD, TLR3, MYD88, ITGB1, IRF1
19	Toll signaling pathway	GO:008063	10.5	TICAM1, TLR3, NFKB1, TBK1, TRAF6, MAPK14
20	toll-like receptor 4 signaling pathway	GO:034142	10.5	MYD88, MAPK14, NFKB1, TLR3, TICAM1, IRF7
21	positive regulation of nitric oxide biosynthetic process	GO:045429	10.4	JAK2, INS, ICAM1, TICAM1, IFNG, TNF
22	lipopolysaccharide-mediated signaling pathway	GO:031663	10.4	TNF, TICAM1, MYD88, MAPK14, STAT1, TGFB1
23	negative regulation of lipid storage	GO:010888	10.4	TNF, ITGB3, IL6, CRP
24	interferon-gamma-mediated signaling pathway	GO:060333	10.4	HLA-DRB1, HLA-DRB4, SOCS3, PTPN11, OAS1, OAS2
25	MyD88-independent toll-like receptor signaling pathway	GO:002756	10.4	TICAM1, IRF7, MAPK14, IKBKE, TRAF6, TBK1
26	positive regulation of NF-kappaB transcription factor activity	GO:051092	10.3	NFKB1, MYD88, ICAM1, TNF, RNF31, AR
27	type I interferon biosynthetic process	GO:045351	10.3	IRF7, IRF9, IFNAR1, MYD88
28	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO:043123	10.3	FADD, MYD88, IKBKE, TRAF6, TBK1, TIRAP
29	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	10.3	CD81, VEGFA, VTN, JAK2, ITGB1, ITGB3
30	TRIF-dependent toll-like receptor signaling pathway	GO:035666	10.3	MAPK14, IRF7, IKBKE, TICAM1, TLR3, TRAF6
31	toll-like receptor 3 signaling pathway	GO:034138	10.3	IRF7, MAPK14, IKBKE, TRAF6, TBK1, TLR3
32	inflammatory response	GO:006954	10.3	NFKB1, TLR3, TLR8, CRP, TLR7, DARC
33	response to drug	GO:042493	10.2	IFNG, IL4, IL10, B2M, LPL, ITGB1
34	positive regulation of interferon-beta production	GO:032728	10.1	DDX58, TLR3, IRF1, IRF7, TBK1, TLR9
35	response to hypoxia	GO:001666	10.1	VCAM1, GPR182, TNF, DRD2, CREBBP, THBS1
36	immune response	GO:006955	9.9	CHIT1, HLA-A, HLA-B, HLA-DOB, HLA-DRB1, HLA-DRB4
37	induction of apoptosis	GO:006917	9.8	PRKRA, IFNA2, LTA, THBS1, TNFRSF19, IFNB1
38	cell surface receptor signaling pathway	GO:007166	9.7	IFNG, IFNB1, IFNAR2, IFNGR2, MYD88, PRL
39	type I interferon-mediated signaling pathway	GO:060337	9.7	IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6
40	positive regulation of protein kinase B signaling cascade	GO:051897	9.7	TNF, THBS1, IGF1, MC1R, INS, TGFB1
41	negative regulation of cell proliferation	GO:008285	9.6	DRD2, IRF1, IL6, IL8, IGF1, IFNK
42	platelet degranulation	GO:002576	9.5	VEGFA, ITGA2B, ITGB3, IGF1, F8, F5
43	platelet activation	GO:030168	9.5	CD40LG, ITGA2B, IL6, ITGB3, MAPK14, VEGFA
44	cytokine-mediated signaling pathway	GO:019221	9.5	OAS2, OAS1, PTPN11, HLA-DRB5, HLA-DRB4, HLA-DRB1
45	response to virus	GO:009615	9.4	IFNE, IFNB1, IFNAR2, IFNAR1, IFNA8, IFNA6
46	blood coagulation	GO:007596	9.3	EFEMP2, PRKAR1B, TGFB1, THBS1, PLG, PTPN11
47	innate immune response	GO:045087	9.3	ISG15, IRAK4, IRF7, IL1R1, FADD, MAPK14
48	positive regulation of transcription from RNA polymerase II promoter	GO:045944	9.0	MAPK14, DRD2, TNF, TRAF6, IFNG, TBK1
49	virus-host interaction	GO:019048	8.3	TRAM1, TGFB1, TBK1, CD209, DDX58, DAG1
50	regulation of immune response	GO:050776	INF	CD81, ITGA4, VCAM1, FCGR2B, IRF7, ITGB1

Molecular functions related to hemorrhagic fever according to GeneDecks:

(show all 15)

id	Name	GO ID	Score	Top Affiliating Genes
1	cytokine receptor binding	GO:005126	11.0	IFNA5, IFNA14, IFNA10, IFNW1, IFNE, IFNA6
2	cytokine activity	GO:005125	11.0	IFNA2, IFNA17, VEGFA, CD40LG, IL10, TNF
3	2-5-oligoadenylate synthetase activity	GO:001730	10.8	OAS3, OASL, OAS2, OAS1
4	peptide antigen binding	GO:042605	10.7	TAP1, HLA-DRB1, HLA-DRB4, HLA-DRB5, CD209
5	interferon-alpha/beta receptor binding	GO:005132	10.7	IFNK, IFNA17, IFNA2, IFNA16, IFNA13, IFNB1
6	tumor necrosis factor receptor binding	GO:005164	10.6	FADD, STAT1, LTA, CD40LG, TNF
7	receptor activity	GO:004872	10.5	TLR8, TLR3, DARC, TRAM1, ICAM1, IL10RA
8	regulatory region DNA binding	GO:000975	10.3	IRF1, IRF9, IRF5
9	fibronectin binding	GO:001968	10.3	VEGFA, ITGA4, THBS1, ITGB1
10	protease binding	GO:002020	10.1	TNF, SERPINC1, ITGB1, INS, IL1R1, F3
11	double-stranded RNA binding	GO:003725	10.1	TLR7, TLR3, DDX58, OAS1, OAS3, OASL
12	growth hormone receptor binding	GO:005131	10.0	JAK2, TYK2, JAK1
13	cell surface binding	GO:043498	10.0	PLG, F3, ICAM1, VEGFA
14	integrin binding	GO:005178	INF	ITGB1, IGF1, ICAM1, ICAM2, , THBS1
15	protein binding	GO:005515	INF	F8, IL4, IL1R2, IL1R1, IL10RA, FCGR2B