MCID: HMR012
MIFTS: 44

Hemorrhagic Fever malady

Infectious diseases category

Summaries for Hemorrhagic Fever

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33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Viral hemorrhagic fevers (vhfs) are a group of illnesses caused by four families of viruses. these include the ebola and marburg, lassa fever, and yellow fever viruses. vhfs have common features: they affect many organs, they damage the blood vessels, and they affect the body's ability to regulate itself. some vhfs cause mild disease, but some, like ebola or marburg, cause severe disease and death. vhfs are found around the world. specific diseases are usually limited to areas where the animals that carry them live. for example, lassa fever is limited to rural areas of west africa where rats and mice carry the virus. the risk for travelers is low, but you should avoid visiting areas where there are disease outbreaks. because there are no effective treatments for some of these viral infections, there is concern about their use in bioterrorism. centers for disease control and prevention

MalaCards: Hemorrhagic Fever, also known as hemorrhagic fevers, viral, is related to dengue hemorrhagic fever and hemorrhagic fever with renal syndrome. An important gene associated with Hemorrhagic Fever is CD40LG (CD40 ligand), and among its related pathways are Influenza A and Allograft rejection. The compounds fibrinogen and cyclosporin a have been mentioned in the context of this disorder. Related mouse phenotypes are cellular and homeostasis/metabolism.

Wikipedia:63 The viral hemorrhagic (or haemorrhagic) fevers (VHFs) are a diverse group of animal and human illnesses... more...

Aliases & Classifications for Hemorrhagic Fever

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42NIH Rare Diseases, 44Novoseek, 33MedlinePlus, 60UMLS, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

hemorrhagic fever 42 44
hemorrhagic fevers, viral 60
hemorrhagic fevers 33


External Ids:

ICD1025 A98.5

Related Diseases for Hemorrhagic Fever

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17GeneCards, 18GeneDecks
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Diseases in the Viral Hemorrhagic Fever family:

hemorrhagic fever

Diseases related to Hemorrhagic Fever via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 290)
idRelated DiseaseScoreTop Affiliating Genes
1dengue hemorrhagic fever31.9IVNS1ABP, LTA, CD40LG, PTPN11
2hemorrhagic fever with renal syndrome31.8PRNT
3ebola hemorrhagic fever31.3EHF, GP2
4argentine hemorrhagic fever31.3TMBIM4
5dengue shock syndrome30.9IVNS1ABP
6thrombocytopenia30.8ITGB3, GPT, F2, SLC17A5, F3, CD40LG
7dengue disease30.7PTPN11, SLC17A5, CD40LG, IVNS1ABP
8pancreatitis30.6IL6, IL10, ICAM1, SLC17A5
9lassa fever30.6GP2, TMBIM4
10rift valley fever30.6PRNT, MX1
11acute pancreatitis30.5GP2, GPT, SLC17A5, IL6, IL10
12hepatitis30.5SLC17A5, F2, GPT
13encephalitis30.4MX1
14disseminated intravascular coagulation30.3F3, F2
15hypertension30.2F2, ICAM1
16cholecystitis30.2GPT
17malaria30.1ICAM1, IL10, TNF
18peritonitis30.1IL6, F2, TNF
19hepatitis a30.1F2
20leptospirosis30.1CD40LG
21lymphocytic choriomeningitis30.1GP2
22viral infectious disease29.9IL10, TNF, ICAM1, IVNS1ABP, LTA, CD40LG
23influenza29.9IVNS1ABP, LTA, RNPC3, MX1, PTPN11
24hepatitis b29.9SLC17A5, F2, GPT, IL10, MX1
25vasculitis29.9F2, ICAM1, TNF, NFKB1, CD40LG
26pneumonia29.9IL10, IL6, TNF, ICAM1
27vascular disease29.9IL10, TNF, IL6, F3
28scrub typhus29.9GPT, SLC17A5, CD40LG
29encephalomyelitis29.9LTA, IL10, TNF
30myocardial infarction29.9ITGB3, F3
31ischemia29.9ICAM1, SLC17A5
32acute liver failure29.9SLC17A5, F2, GPT
33acute myocardial infarction29.9F3
34acquired immunodeficiency syndrome29.9IL6
35kawasaki disease29.9GPT
36neutropenia29.9GPT
37leishmaniasis29.9IL10
38polyneuropathy29.9CD40LG
39yellow fever29.9PRNT
40japanese encephalitis29.9IVNS1ABP, PTPN11
41visceral leishmaniasis29.9LTA, IL10
42crimean-congo hemorrhagic fever11.2
43hemorrhagic disease10.8
44korean hemorrhagic fever10.8
45marburg hemorrhagic fever10.7
46bolivian hemorrhagic fever10.7
47omsk hemorrhagic fever10.6
48alkhurma hemorrhagic fever10.6
49venezuelan hemorrhagic fever10.6
50nephropathia epidemica10.5

Graphical network of the top 20 diseases related to Hemorrhagic Fever:



Diseases related to hemorrhagic fever

Clinical Features for Hemorrhagic Fever

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Drugs & Therapeutics for Hemorrhagic Fever

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Hemorrhagic Fever

Drug clinical trials:

Search ClinicalTrials for Hemorrhagic Fever

Search NIH Clinical Center for Hemorrhagic Fever

Search CenterWatch for Hemorrhagic Fever

Genetic Tests for Hemorrhagic Fever

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Anatomical Context for Hemorrhagic Fever

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Animal Models for Hemorrhagic Fever or affiliated genes

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36MGI
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Publications for Hemorrhagic Fever

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Genetic Variations for Hemorrhagic Fever

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Expression for genes affiliated with Hemorrhagic Fever

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hemorrhagic Fever

Search GEO for disease gene expression data for Hemorrhagic Fever.

Pathways for genes affiliated with Hemorrhagic Fever

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Sources:
29KEGG, 51QIAGEN, 37NCBI BioSystems Database, 12EMD Millipore, 52R&D Systems, 53Reactome
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Pathways related to Hemorrhagic Fever according to GeneCards/GeneDecks:

(show all 48)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.9PTPN11, ICAM1, TNF, IVNS1ABP, NFKB1, LTA
2
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10.8ICAM1, TNF, LTA, CD40LG, IL10, IL6
3
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10.8TNF, ITGB3, NFKB1, LTA, IL10, IL6
4
Development PDGF signaling via STATs and NF-kB
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10.8TNF, NFKB1, IL10, IL6, F2, PTPN11
510.7ICAM1, TNF, NFKB1, LTA, CD40LG
6
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10.7TNF, NFKB1, LTA, IL6, PTPN11
710.7F2, IL6, NFKB1, TNF, ICAM1
810.7ICAM1, TNF, NFKB1, LTA, IL6
9
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10.7ICAM1, NFKB1, IL6, MX1, PTPN11
10
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10.7TNF, NFKB1, LTA, IL6
11
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10.7TNF, NFKB1, LTA, IL6
12
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10.7TNF, NFKB1, IL6, F3
1310.7TNF, LTA, IL10, IL6
14
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10.7IL6, IL10, LTA, TNF
1510.7ITGB3, LTA, CD40LG, IL10
16
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10.7TNF, NFKB1, IL6, PTPN11
1710.7ICAM1, TNF, NFKB1, IL6
1810.7ICAM1, TNF, NFKB1, IL6
1910.7ICAM1, TNF, IL10, IL6
2010.7IL6, IL10, NFKB1, TNF
2110.7TNF, NFKB1, IL10, IL6
2210.7IL6, IL10, NFKB1, TNF
23
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10.7TNF, NFKB1, IL10, IL6
24
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10.7ICAM1, ITGB3, NFKB1, PTPN11
2510.6TNF, ITGB3, IL6
26
Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
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10.6CD40LG, NFKB1, TNF
27
Immune response Bacterial infections in normal airways
10.6IL6, NFKB1, TNF
28
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10.6IL6, NFKB1, TNF
29
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10.6F2, LTA, ITGB3
30
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10.6NFKB1, CD40LG, PTPN11
31
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10.6TNF, NFKB1, LTA
3210.6TNF, NFKB1, LTA
3310.6PTPN11, IL6, NFKB1
34
Immune response IL-6 signaling pathway
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10.6PTPN11, IL6, NFKB1
3510.6TNF, NFKB1, PTPN11
36
Cytokine production by Th17 cells in CF (Mouse model)
10.6ICAM1, NFKB1, IL6
3710.6IL6, NFKB1, ICAM1
3810.6TNF, NFKB1, IL10
39
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10.6NFKB1, LTA, PTPN11
40
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10.6NFKB1, LTA, PTPN11
4110.6PTPN11, NFKB1, ICAM1
4210.6NFKB1, LTA, IL10
43
Hide members
10.6CD40LG, NFKB1
4410.6PTPN11, ITGB3
4510.6IL10, NFKB1
4610.5NFKB1
4710.5NFKB1
48
Hide members
10.5NFKB1

Compounds for genes affiliated with Hemorrhagic Fever

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Sources:
44Novoseek, 28IUPHAR, 59Tocris Bioscience, 49PharmGKB, 11DrugBank, 24HMDB
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Compounds related to Hemorrhagic Fever according to GeneCards/GeneDecks:

(show top 50)    (show all 154)
idCompoundScoreTop Affiliating Genes
1fibrinogen4411.4F3, ICAM1, TNF, ITGB3, CD40LG, IL6
2cyclosporin a44 28 5913.4GPT, TNF, LTA, CD40LG, RNPC3, ICAM1
3neopterin4411.4LTA, IL6, GPT, MX1, SLC17A5, CD40LG
4simvastatin44 49 59 28 11 2416.3ICAM1, TNF, IL10, IL6, F3, GPT
5vegf4411.3LTA, CD40LG, PTPN11, TNF, F3, ICAM1
6alanine4411.3IL6, F3, GPT, F2, MX1, PTPN11
7lactate4411.3ICAM1, IL6, SLC17A5, CD40LG, F2, LTA
8atorvastatin44 49 28 11 2415.3ICAM1, IL6, GPT, SLC17A5, CD40LG, TNF
9hyaluronic acid44 2412.2CD40LG, LTA, ICAM1, GPT, SLC17A5, F2
10n acetylcysteine4411.2ICAM1, TNF, CD40LG, IL6, GPT, F2
11fenofibrate44 49 1113.2ICAM1, CD40LG, IL6, GPT, SLC17A5, TNF
12okt34411.2CD40LG, IL6, IL10, LTA, TNF, ICAM1
13rantes4411.2ICAM1, PTPN11, IL6, TNF, LTA, CD40LG
14herbimycin a44 5912.2IL6, ICAM1, PTPN11, CD40LG, LTA, TNF
15methotrexate44 49 1113.1SLC17A5, F2, GPT, IL6, TNF, IL10
16ifn-alpha4411.1PTPN11, GPT, MX1, IL6, IL10
17hepaplastin4411.1F3, GPT, F2, SLC17A5
18cdp5714411.1ICAM1, IL6, IL10, TNF
19thalidomide44 49 59 1114.1TNF, IL6, IL10, CD40LG, NFKB1
20nitric oxide44 11 2413.1TNF, PTPN11, SLC17A5, IL6, IL10, LTA
21ribavirin44 49 1113.1CD40LG, SLC17A5, MX1, IL10
22endotoxin4411.1SLC17A5, F3, ICAM1
23tirofiban44 1112.0F3, ITGB3, CD40LG, F2
24il-124411.0TNF, CD40LG, IL10, IL6
25imiquimod44 28 59 1114.0TNF, IL6, IL10, MX1
26sb 20358044 5912.0F3, IL6, IL10, TNF, PTPN11, ICAM1
27ivig4411.0GPT, CD40LG
28abciximab44 1112.0CD40LG, F2, F3, ITGB3
29pentoxifylline44 1112.0LTA, F3
30polymyxin b4411.0IL6, TNF, ICAM1, IL10
312,5-oligoadenylate4411.0MX1, TNF
32groalpha4411.0TNF, IL6, IL10, ICAM1
33prednisolone44 28 1113.0LTA, SLC17A5
34clopidogrel49 44 11 2414.0CD40LG, F3, ITGB3, F2
35lipoteichoic acid4411.0IL10, LTA, TNF, IL6
368-isoprostane4410.9IL6, IL10, ICAM1, TNF
37troglitazone44 28 59 1113.9ICAM1, GPT, SLC17A5, IL6, TNF
38aprotinin44 1111.9F3, SLC17A5
39ulinastatin4410.9ICAM1
40gm-csf44 2811.9TNF, IL10, ICAM1
41aspartate4410.9SLC17A5, CD40LG, GPT, F2
42lamivudine44 1111.9F2, SLC17A5
43serine4410.8LTA, TMBIM4, TNF, MX1, RNPC3, PTPN11
44ximelagatran44 1111.8F3, GPT, F2
45d-galactosamine4410.8TNF, GPT, SLC17A5
46interferon gamma4410.7IL10, TNF, ICAM1
47etanercept44 49 1112.7IL6, TNF, LTA, IL10
48protamine4410.6F2, RNPC3, F3
49ursodeoxycholic acid44 11 2412.6CD40LG, SLC17A5, GPT, F2
50cycloheximide4410.3LTA, MX1

GO Terms for genes affiliated with Hemorrhagic Fever

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16Gene Ontology
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Cellular components related to Hemorrhagic Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00989710.7IL6, CD40LG, TNF, ICAM1
2extracellular spaceGO:00561510.6F2, ICAM1, TNF, LTA, CD40LG, IL10

Biological processes related to Hemorrhagic Fever according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of apoptotic processGO:04306611.1IVNS1ABP, NFKB1, CD40LG, IL10, IL6, TMBIM4
2response to drugGO:04249311.1ICAM1, TNF, LTA, IL10, IL6
3inflammatory responseGO:00695411.0IL6, IL10, CD40LG, NFKB1, TNF
4positive regulation of NF-kappaB transcription factor activityGO:05109211.0ICAM1, TNF, NFKB1, IL6
5leukocyte migrationGO:05090011.0PTPN11, F2, ITGB3, ICAM1
6negative regulation of lipid storageGO:01088811.0IL6, ITGB3, TNF
7negative regulation of growth of symbiont in hostGO:04413011.0IL10, LTA, TNF
8positive regulation of nitric oxide biosynthetic processGO:04542910.9ICAM1, TNF, IL6
9defense response to Gram-positive bacteriumGO:05083010.9TNF, LTA, IL6
10positive regulation of chronic inflammatory response to antigenic stimulusGO:00287610.9LTA, TNF
11humoral immune responseGO:00695910.9IL6, LTA, TNF
12platelet activationGO:03016810.9F2, IL6, CD40LG, ITGB3
13receptor biosynthetic processGO:03280010.9TNF, IL10
14regulation of immunoglobulin secretionGO:05102310.8CD40LG, TNF
15cytokine-mediated signaling pathwayGO:01922110.8ICAM1, IL6, MX1, PTPN11
16positive regulation of humoral immune response mediated by circulating immunoglobulinGO:00292510.8TNF, LTA
17negative regulation of cytokine secretion involved in immune responseGO:00274010.8IL10
18epithelial cell proliferation involved in salivary gland morphogenesisGO:06066410.8IL6, TNF
19response to glucocorticoid stimulusGO:05138410.7IL6, IL10, TNF
20positive regulation of transcription, DNA-dependentGO:04589310.7TNF, NFKB1, EHF, IL10, IL6
21positive regulation of protein kinase B signaling cascadeGO:05189710.7TNF, IL6, F3
22B cell proliferationGO:04210010.6IL10, CD40LG
23positive regulation of sequence-specific DNA binding transcription factor activityGO:05109110.5IL6, IL10, TNF
24positive regulation of protein phosphorylationGO:00193410.3TNF, ITGB3, F2

Molecular functions related to Hemorrhagic Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor receptor bindingGO:00516410.6CD40LG, LTA, TNF
2cytokine activityGO:00512510.4IL6, IL10, CD40LG, LTA, TNF

Products for genes affiliated with Hemorrhagic Fever

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Sources for Hemorrhagic Fever

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet