HFRS
MCID: HMR004
MIFTS: 58

Hemorrhagic Fever with Renal Syndrome (HFRS) malady

Categories: Infectious diseases, Rare diseases, Skin diseases, Nephrological diseases

Aliases & Classifications for Hemorrhagic Fever with Renal Syndrome

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Sources:
11Disease Ontology, 13DISEASES, 30ICD10, 31ICD10 via Orphanet, 32ICD9CM, 39MeSH, 40MESH via Orphanet, 45NCIt, 54Orphanet, 62SNOMED-CT, 68UMLS, 69UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Hemorrhagic Fever with Renal Syndrome:

Name: Hemorrhagic Fever with Renal Syndrome 11 39 13 68
Hantavirosis 54 68
Hemorrhagic Fever-Renal Syndrome 54
Hemorrhagic Nephrosonephritis 11
 
Hemorrhagic Fever, Russian 11
Puumala Virus Nephropathy 11
Hantavirus Fever 54
Hfrs 11

Characteristics:

Orphanet epidemiological data:

54
hantavirosis:
Prevalence: 1-9/1000000 (Europe); Age of onset: All ages; Age of death: any age

Classifications:



External Ids:

Disease Ontology11 DOID:11266
ICD1030 A98.5
ICD9CM32 078.6
MeSH39 D006480
NCIt45 C84753
Orphanet54 ORPHA340
MESH via Orphanet40 C535630, D006480
UMLS via Orphanet69 C0019101, C2930957
ICD10 via Orphanet31 A98.5+, N08.0*

Summaries for Hemorrhagic Fever with Renal Syndrome

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Disease Ontology:11 A viral infectious disease that is a hemorrhagic fever, located in kidney, has material basis in Hantaan virus, has material basis in Dobrava-Belgrade virus, has material basis in Seoul virus, or has material basis in Puumala virus, which are carried and transmitted by rodents. The infection has symptom headache, has symptom fever, has symptom muscle pains, has symptom facial flush, has symptom petechiae, has symptom hemorrhagic features, has symptom proteinuria, and has symptom renal failure.

MalaCards based summary: Hemorrhagic Fever with Renal Syndrome, also known as hantavirosis, is related to labyrinthitis and hepatitis, and has symptoms including Array, Array and Array. An important gene associated with Hemorrhagic Fever with Renal Syndrome is CD40LG (CD40 Ligand), and among its related pathways are Overview of nanoparticle effects and amb2 Integrin signaling. Affiliated tissues include kidney, kidney and t cells, and related mouse phenotypes are digestive/alimentary and liver/biliary system.

Related Diseases for Hemorrhagic Fever with Renal Syndrome

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Diseases related to Hemorrhagic Fever with Renal Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 315)
idRelated DiseaseScoreTop Affiliating Genes
1labyrinthitis29.6IL10, IL6, TNF
2hepatitis29.1HLA-DRB1, IFNG, IL10, IL6, TNF
3myocardial infarction29.1ALB, CRP, IL10, IL6, TNF
4korean hemorrhagic fever11.8
5nephropathia epidemica11.3
6hantavirus pulmonary syndrome11.3
7hemorrhagic fever11.0
8pancreatitis, hereditary10.9
9balkan hemorrhagic fever10.9
10vps11-related autosomal recessive hypomyelinating leukodystrophy10.3IL6, TNF
11coloboma of iris10.3CRP, IL6
12dyslexia 510.3IL6, TNF
13congenital dyserythropoietic anemia10.3ALB, TNF
14aortic atherosclerosis10.3IL6, TNF
15degenerative disc disease10.3IL6, TNF
16gilles de la tourette syndrome10.3ALB, B2M
17bile duct adenocarcinoma10.3ALB, CD40LG
18dextrocardia10.2CD40LG, IL6, TNF
19ethmoid sinus schneiderian papilloma10.2B2M, CD40LG, IL6
20unilateral multicystic dysplastic kidney10.2CRP, IL6, TNF
21mineral metabolism disease10.2CD40LG, IL6, TNF
22joint disorders10.2CRP, IL6, TNF
23cicatricial lagophthalmos10.2CRP, IL6, TNF
24benign neonatal seizures10.2CRP, IL6, TNF
25glycogen storage disease viii10.2B2M, CD40LG, CRP
26colloid adenoma10.2ALB, CD40LG
27tall cell variant papillary carcinoma10.2B2M, CD40LG, IL6
28neuropathy10.2CRP, IL6, TNF
29autoimmune disease of central nervous system10.2CRP, IL6, TNF
30retinal degeneration10.2CD40LG, CRP, IL6
31functional gastric disease10.2CD40LG, CRP, TNF
32pancreas lymphoma10.2CRP, IL6, TNF
33uterine adnexa cancer10.2CD40LG, IL6, TNF
34blepharochalasis10.2CRP, IL6, TNF
35cutaneous sclerosis10.2CRP, IL6
36retinitis pigmentosa 5110.2CRP, IL6, TNF
37estrogen excess10.2ALB, CD40LG
38chondroma10.2CRP, IL6, TNF
39angiomatosis, diffuse corticomeningeal, of divry and van bogaert10.2HLA-DRB1, IL6, TNF
40celiac disease10.2CD40LG, CRP, TNF
41limb ischemia10.2CRP, IL6, TNF
42diabetic encephalopathy10.2CRP, IL6, TNF
43cranial nerve palsy10.2B2M, CRP, TNF
44neovascular glaucoma10.2CRP, IL6, TNF
45pseudohypoparathyroidism10.2B2M, CD40LG, HLA-DRB1
46bilateral parasagittal parieto-occipital polymicrogyria10.2HLA-DRB1, TNF
47endobronchial leiomyoma10.2CD40LG, CRP, TNF
48motility-related diarrhea10.2HLA-DRB1, IL6, TNF
49haemonchiasis10.2CD40LG, CRP, TNF
50angiokeratoma10.2ALB, B2M, CD40LG

Graphical network of the top 20 diseases related to Hemorrhagic Fever with Renal Syndrome:



Diseases related to hemorrhagic fever with renal syndrome

Symptoms & Phenotypes for Hemorrhagic Fever with Renal Syndrome

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Symptoms:

 11 (show all 8)
  • headache
  • fever
  • muscle pains
  • facial flush
  • petechiae
  • hemorrhagic features
  • proteinuria
  • renal failure

Human phenotypes related to Hemorrhagic Fever with Renal Syndrome:

 54 64 (show all 32)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 renal insufficiency64 54 Frequent (79-30%) HP:0000083
2 abnormality of the renal tubule54 Frequent (79-30%)
3 proteinuria64 54 Frequent (79-30%) HP:0000093
4 conjunctivitis64 54 Frequent (79-30%) HP:0000509
5 myopia64 54 Occasional (29-5%) HP:0000545
6 photophobia64 54 Frequent (79-30%) HP:0000613
7 hypertension64 54 Occasional (29-5%) HP:0000822
8 abnormality of the myocardium64 54 Occasional (29-5%) HP:0001637
9 abnormality of the pericardium64 54 Occasional (29-5%) HP:0001697
10 thrombocytopenia64 54 Frequent (79-30%) HP:0001873
11 fever64 54 Very frequent (99-80%) HP:0001945
12 tubulointerstitial abnormality64 54 Frequent (79-30%) HP:0001969
13 leukocytosis64 54 Frequent (79-30%) HP:0001974
14 abdominal pain64 54 Frequent (79-30%) HP:0002027
15 migraine64 54 Frequent (79-30%) HP:0002076
16 respiratory insufficiency64 54 Frequent (79-30%) HP:0002093
17 hemoptysis64 54 Occasional (29-5%) HP:0002105
18 pulmonary infiltrates64 54 Frequent (79-30%) HP:0002113
19 intracranial hemorrhage64 54 Occasional (29-5%) HP:0002170
20 pleural effusion64 54 Frequent (79-30%) HP:0002202
21 gastrointestinal hemorrhage64 54 Occasional (29-5%) HP:0002239
22 hypotension64 54 Occasional (29-5%) HP:0002615
23 arthralgia64 54 Frequent (79-30%) HP:0002829
24 elevated hepatic transaminases64 54 Frequent (79-30%) HP:0002910
25 hypoproteinemia64 54 Frequent (79-30%) HP:0003075
26 myalgia64 54 Frequent (79-30%) HP:0003326
27 arrhythmia64 54 Occasional (29-5%) HP:0011675
28 subconjunctival hemorrhage64 54 Frequent (79-30%) HP:0011896
29 fatigue64 54 Very frequent (99-80%) HP:0012378
30 oliguria64 54 Frequent (79-30%) HP:0100520
31 amaurosis fugax64 54 Occasional (29-5%) HP:0100576
32 atelectasis64 54 Frequent (79-30%) HP:0100750

MGI Mouse Phenotypes related to Hemorrhagic Fever with Renal Syndrome according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.6ALB, B2M, IFNG, IL10, IL6, TNF
2MP:00053708.5ALB, B2M, IFNG, IL10, IL6, TNF
3MP:00020068.5ALB, B2M, IFNG, IL10, IL6, TNF
4MP:00053798.4ALB, B2M, CD40LG, IFNG, IL10, IL6
5MP:00053857.6B2M, CD163, CD40LG, CRP, IFNG, IL10
6MP:00053877.5B2M, CD163, CD40LG, CRP, IFNG, IL10
7MP:00053977.5B2M, CD163, CD40LG, IFNG, IL10, IL6
8MP:00053907.4CD40LG, HLA-DRB5, IFNG, IL10, IL6, SEMA4D
9MP:00053766.7ALB, B2M, CD163, CD40LG, CRP, IFNG

Drugs & Therapeutics for Hemorrhagic Fever with Renal Syndrome

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Drugs for Hemorrhagic Fever with Renal Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1AntibodiesPhase 36394
2VaccinesPhase 3, Phase 2, Phase 16611
3ImmunoglobulinsPhase 36394
4
Epinephrineapproved, vet_approvedPhase 2, Phase 198551-43-45816
Synonyms:
(-)-(R)-Epinephrine
(-)-3,4-Dihydroxy-a-[2-(methylamino)ethyl]benzyl alcohol
(-)-3,4-Dihydroxy-alpha-((methylamino)methyl)benzyl alcohol
(-)-3,4-Dihydroxy-alpha-[2-(methylamino)ethyl]benzyl alcohol
(-)-3,4-dihydroxy-a-[(methylamino)methyl]-Benzyl alcohol
(-)-3,4-dihydroxy-alpha-[(methylamino)methyl]-Benzyl alcohol
(-)-Adrenalin
(-)-Adrenaline
(-)-Epinephrine
(-)-R-Epinephrine
(R)-(-)-Adnephrine
(R)-(-)-Adrenaline
(R)-(-)-Epinephrine
(R)-(-)-Epirenamine
(R)-(−)-adrenaline
(R)-4-[1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
(R)-4-[1-hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol
(R)-Adrenaline
(R)-Epinephrine
(−)-adrenaline
02252_FLUKA
1-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
1-Adrenalin
1-Epinephrine
4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-benzenediol
4-(1-hydroxy-2-methylamino-ethyl)benzene-1,2-diol
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol
51-43-4
51-43-4 (FREE BASE)
51028-73-0
A0173
AC-13188
AC1L1L7B
ADR ADRENALINE
ADROP
AI3-19015
Adnephrine
Adrenal
Adrenalin
Adrenalin (TN)
Adrenalin in Oil
Adrenalin-Medihaler
Adrenalina
Adrenalina [DCIT]
Adrenaline
Adrenaline (JP15)
Adrenaline/Epinephrine
Adrenalinum
Adrenamine
Adrenan
Adrenapax
Adrenasol
Adrenatrate
Adrenine
Adrenodis
Adrenohorma
Adrenosan
Adrenutol
Adrin
Adrine
Ana-Guard
Ana-Kit
Antiasthmatique
Asmatane Mist
Asthma meter mist
Asthma-nefrin
Asthmahaler Mist
Asthmanefrin
Astmahalin
Astminhal
BIDD:GT0119
Balmadren
Bernarenin
Biorenine
Bosmin
Brevirenin
Bronkaid
Bronkaid Mist
Bronkaid Suspension Mist
Bupivacaine Hcl and Epinephrine
C00788
CCRIS 4812
CHEBI:28918
CHEMBL679
CID5816
Chelafrin
Citanest Forte
Corisol
D-Epifrin
D-Epinephrine
D00095
DB00668
Drenamist
Dylephrin
Dyspne-Inhal
E4250_SIGMA
EINECS 200-098-7
EPI E Z PEN JR
EPIPEN E Z PEN
EPIPEN JR
Epi EZ Pen Jr
Epifrin
Epiglaufrin
Epinefrin
Epinefrin [Czech]
Epinefrina
Epinefrina [INN-Spanish]
Epinephran
Epinephrin
Epinephrine
Epinephrine (USP)
Epinephrine (USP/INN)
Epinephrine [USAN:INN:JAN]
Epinephrine hydrochloride
Epinephrinum
Epinephrinum [INN-Latin]
Epipen
Epipen (TN)
Epipen Auto-Injector
Epipen EZ Pen
Epipen Jr.
Epipen Jr. Auto-Injector
Epirenamine
Epirenan
Epirenin
Epitrate
Eppy
Esphygmogenina
Exadrin
 
Glaucon
Glaucosan
Glauposine
Glycirenan
HSCI1_000215
HSDB 4289
Haemostasin
Haemostatin
Hektalin
Hemisine
Hemostasin
Hemostatin
Hypernephrin
Hyporenin
IOP
Intranefrin
Iontocaine
Isoptoepinal
Kidoline
L-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
L-Adrenaline
L-Adrenaline Base
L-Epinehphrine
L-Epinephrine
L-Epirenamine
L-Methylaminoethanolcatechol
L-epinephrine
LS-156
Levo-Methylaminoethanolcatechol
Levoadrenaline
Levoepinephrine
Levorenen
Levorenin
Levorenine
Levoreninum
Lopac-E-4642
Lyodrin
Lyophrin
Medihaler-Epi
Metanephrin
Methylaminoethanolcatechol
Methylarterenol
Micronefrin
Micronephrine
MolPort-002-051-368
Mucidrina
Myosthenine
Mytrate
NCGC00015417-01
NCGC00142615-01
NCGC00142615-03
NCGC00142615-04
NCGC00142615-05
NCGC00142615-06
NCGC00142615-07
NSC 62786
NSC62786
Nephridine
Nieraline
PDSP1_001120
PDSP2_001104
Paranephrin
Primatene
Primatene Mist
R-(-)-Epinephrine
R-Adrenaline
RCRA waste no. P042
Racemic Epinephrine
Racepinephrine
Rcra waste number P042
Renagladin
Renaglandin
Renaglandulin
Renaleptine
Renalina
Renoform
Renostypricin
Renostypticin
Renostyptin
SMP1_000227
ST069368
SUS-PHRINE SULFITE-FREE
Scurenaline
Septocaine
Simplene
Sindrenina
Soladren
Sphygmogenin
Stryptirenal
Styptirenal
Supracapsulin
Supradin
Supranefran
Supranephrane
Supranephrine
Supranol
Suprarenaline
Suprarenin
Suprel
Surenine
Surrenine
Sus-Phrine
Sus-phrine
Susphrine
Sympathin I
Takamina
Takamine
Tokamina
Tonogen
Twinject
Twinject 0.15
Twinject 0.3
Twinject 0.30
UNII-YKH834O4BH
Vaponefrin
Vasoconstrictine
Vasoconstrictor
Vasodrine
Vasoton
Vasotonin
adrenaline
bmse000316
d-Adrenaline
epinephrine
l-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
l-Adrenalin
l-Adrenaline
l-Epinephine
l-Epinephrine (synthetic)
l-Epirenamine
l-Methylaminoethanolcatechol
levoepinephrine
nchembio747-comp9
5
RibavirinapprovedPhase 2100336791-04-537542
Synonyms:
1-.beta.-D-Ribofuranosyl-1,2,4-triazolo-3-carboxamide
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazole-3-carboxamide
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-1,2,4-triazole-3-carboxamide
1-beta-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide
1-beta-D-Ribofuranosyl-1H-1,2,4-triazole-3-carboxamide
1-beta-D-ribofuranosyl-1-H-1,2,4-triazole-3-carboxamide
36791-04-5
437710-49-1
66510-90-5
AA-504/07617051
AB00430481
AC1L1XXZ
AC1Q1IDC
AC1Q4ZGS
AKOS001715163
BB_NC-0567
BPBio1_001195
BRN 0892462
BSPBio_001085
BSPBio_003352
C-Virin
CHEMBL1643
CID37542
Copegus
Copegus (TN)
Cotronak
D00423
DB00811
DRG-0028
DivK1c_000782
Drug: Ribavirin
EU-0101063
FT-0082885
HMS2090L15
HMS2094O09
HMS502H04
HSDB 6513
ICN-1229
IDI1_000782
KBio1_000782
KBio2_002328
KBio2_004896
KBio2_007464
KBio3_002854
KBioGR_001804
KBioSS_002331
KS-1104
LS-1241
Lopac0_001063
MLS000028486
MLS002222317
MolPort-002-507-104
MolPort-002-885-856
NCGC00090726-01
NCGC00090726-03
NCGC00090726-04
NCGC00090726-05
NCGC00090726-06
NCGC00090726-07
NINDS_000782
NSC 163039
 
NSC163039
Prestwick3_000993
R 9644
R-964
R9644_SIGMA
RBV
RG-964
RIBAV
RTC
RTCA
RTP
Ravanex
Rebetol
Rebetol (TN)
Rebetron
Rebretron
Ribacine
Ribamide
Ribamidil
Ribamidyl
Ribasphere
Ribasphere (TN)
Ribav
Ribavirin
Ribavirin (JAN/USP/INN)
Ribavirin Capsules
Ribavirin Triphosphate
Ribavirin [USAN:INN]
Ribavirin-TP
Ribavirina
Ribavirina [INN-Spanish]
Ribavirine
Ribavirine [INN-French]
Ribavirinum
Ribavirinum [INN-Latin]
Ribovirin
Ro 20-9963/000
Ro-20-9963
S2504_Selleck
SCH 18908
SMP1_000261
SMR000058315
SPECTRUM1503938
SR-01000076112-3
Spectrum3_001876
Spectrum4_001252
Spectrum5_002075
Spectrum_001826
Tribavirin
UNII-49717AWG6K
Varazid
Vilona
Viramid
Viramide
Virazid
Virazide
Virazole
Virazole (Ribavirin) Inhalation Solution
Virazole (TN)
Virazole 5'-triphosphate
ZINC01035331
ribavirin
6Epinephryl boratePhase 2, Phase 1985
7RacepinephrinePhase 2, Phase 1985
8Antiviral AgentsPhase 29967
9AntimetabolitesPhase 212054
10Anti-Infective AgentsPhase 222062

Interventional clinical trials:

idNameStatusNCT IDPhase
1Study to Evalutate Long-term Immunity of Hantavax in High Risk Population of HFRSCompletedNCT02360514Phase 3
2Phase 2a Immunogenicity Study of Hantaan/Puumala Virus DNA Vaccine for Prevention of Hemorrhagic FeverActive, not recruitingNCT02116205Phase 2
3Ribavirin for Hemorrhagic Fever With Renal SyndromeEnrolling by invitationNCT00623168Phase 2
4Ribavirin for Hemorrhagic Fever With Renal Syndrome in GermanyWithdrawnNCT00868946Phase 2
5Palifermin in Preventing Oral Mucositis Caused by Chemotherapy and/or Radiation Therapy in Young Patients Undergoing Stem Cell TransplantWithdrawnNCT00728585Phase 2
6Study to Evaluate the Safety, Tolerability, and Immunogenicity of Hantaan and Puumala Virus DNA VaccinesCompletedNCT01502345Phase 1
7Diagnostic of Puumala Virus Infection in FranceRecruitingNCT02455375
8Cohort of Patients Infected by an ArbovirusRecruitingNCT01099852
9Phenotyping IBS: Perceptions and Modulations of Visceral SensationsRecruitingNCT02693730

Search NIH Clinical Center for Hemorrhagic Fever with Renal Syndrome


Cochrane evidence based reviews: hemorrhagic fever with renal syndrome

Genetic Tests for Hemorrhagic Fever with Renal Syndrome

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Anatomical Context for Hemorrhagic Fever with Renal Syndrome

About this section

MalaCards organs/tissues related to Hemorrhagic Fever with Renal Syndrome:

36
Kidney, T cells, Testes, Skin, B cells, Endothelial, Neutrophil

FMA organs/tissues related to Hemorrhagic Fever with Renal Syndrome:

17
Kidney

Publications for Hemorrhagic Fever with Renal Syndrome

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Articles related to Hemorrhagic Fever with Renal Syndrome:

(show top 50)    (show all 370)
idTitleAuthorsYear
1
Lack of association between integrin I+vI^3 gene polymorphisms and hemorrhagic fever with renal syndrome in Han Chinese from Hubei, China. (28190175)
2017
2
Prevalence of hemorrhagic fever with renal syndrome in Qingdao City, China, 2010-2014. (27786303)
2016
3
Phylogeographic analysis of hemorrhagic fever with renal syndrome patients using multiplex PCR-based next generation sequencing. (27221218)
2016
4
History of incomplete vaccination may associate with occurrence of hemorrhagic fever with renal syndrome with relieved clinical symptoms. (26636561)
2016
5
Changes in Plasma Adiponectin Concentrations in Patients With Hemorrhagic Fever With Renal Syndrome: An Observational Prospective Study. (26871804)
2016
6
Time Series Analysis of Hemorrhagic Fever with Renal Syndrome: A Case Study in Jiaonan County, China. (27706256)
2016
7
Epidemiological analysis of hemorrhagic fever with renal syndrome in China with the seasonal-trend decomposition method and the exponential smoothing model. (27976704)
2016
8
Prevalence of hemorrhagic fever with renal syndrome in Yiyuan County, China, 2005-2014. (26852019)
2016
9
The assessment of Hantaan virus-specific antibody responses after the immunization program for hemorrhagic fever with renal syndrome in northwest China. (27824286)
2016
10
Spatio-Temporal Pattern and Influencing Factors of Hemorrhagic Fever with Renal Syndrome (HFRS) in Hubei Province (China) between 2005 and 2014. (28030550)
2016
11
Hemorrhagic Fever with Renal Syndrome: Pathogenesis and Clinical Picture. (26870699)
2016
12
Corrigendum: Hemorrhagic Fever with Renal Syndrome: Pathogenesis and Clinical Picture. (27981038)
2016
13
Genovariation Study of Hantavirus in Main Endemic Areas of Hemorrhagic Fever with Renal Syndrome in Hebei Province, China. (27442527)
2016
14
Construction of a Seasonal Difference-Geographically and Temporally Weighted Regression (SD-GTWR) Model and Comparative Analysis with GWR-Based Models for Hemorrhagic Fever with Renal Syndrome (HFRS) in Hubei Province (China). (27801870)
2016
15
Effects of Humidity Variation on the Hantavirus Infection and Hemorrhagic Fever with Renal Syndrome Occurrence in Subtropical China. (26711521)
2016
16
Clinical characterization of two severe cases of hemorrhagic fever with renal syndrome (HFRS) caused by hantaviruses Puumala and Dobrava-Belgrade genotype Sochi. (27842513)
2016
17
Molecular Diagnosis of Hemorrhagic Fever with Renal Syndrome Caused by Puumala Virus. (26962084)
2016
18
Hemorrhagic Fever with Renal Syndrome, Zibo City, China, 2006-2014. (26812444)
2016
19
Cytokine response to Hantaan virus infection in patients with hemorrhagic fever with renal syndrome. (27943332)
2016
20
HMGB-1 as a novel predictor of disease severity and prognosis in patients with hemorrhagic fever with renal syndrome. (25944988)
2015
21
Letter on the article "An hemorrhagic fever with renal syndrome revealing a leptospirosis". (26160283)
2015
22
Correction: Spatiotemporal Transmission Dynamics of Hemorrhagic Fever with Renal Syndrome in China, 2005-2012. (25799067)
2015
23
Changes in rodent abundance and weather conditions potentially drive hemorrhagic fever with renal syndrome outbreaks in Xi'an, China, 2005-2012. (25822936)
2015
24
Puumala Hantavirus-Induced Hemorrhagic Fever with Renal Syndrome Must Be Considered across the Borders of Nephrology to Avoid Unnecessary Diagnostic Procedures. (26650941)
2015
25
Modeling and predicting hemorrhagic Fever with renal syndrome trends based on meteorological factors in hu county, china. (25875211)
2015
26
Comparison of Two Hybrid Models for Forecasting the Incidence of Hemorrhagic Fever with Renal Syndrome in Jiangsu Province, China. (26270814)
2015
27
Acalculous cholecystitis and hemorrhagic fever with renal syndrome. (26139306)
2015
28
Long-term persistence of anti-hantavirus antibodies in sera of patients undergoing hemorrhagic fever with renal syndrome and subjects vaccinated against the disease. (26654580)
2015
29
Elevated serum levels of decoy receptor 3 are associated with disease severity in patients with hemorrhagic fever with renal syndrome. (25647584)
2015
30
Acalculous cholecystitis and hemorrhagic fever with renal syndrome. (26790561)
2015
31
Effects of Climate and Rodent Factors on Hemorrhagic Fever with Renal Syndrome in Chongqing, China, 1997-2008. (26193359)
2015
32
Community Acquired Severe Acute Kidney Injury Caused by Hantavirus-Induced Hemorrhagic Fever with Renal Syndrome Has a Favorable Outcome. (26139246)
2015
33
Hemorrhagic fever with renal syndrome-related encephalopathy: magnetic resonance imaging findings. (26362353)
2015
34
Using autoregressive integrated moving average model to predict the incidence of hemorrhagic fever with renal syndrome in Zibo, China, 2004-2014. (26370428)
2015
35
Acalculous cholecystitis associated with hemorrhagic fever with renal syndrome: a case report. (25982259)
2015
36
Upregulation of IFN-I^ and IL-12 is associated with a milder form of hantavirus hemorrhagic fever with renal syndrome. (24942310)
2014
37
Increased risk for lymphoma following hemorrhagic fever with renal syndrome. (24965350)
2014
38
Early indicators of severity and construction of a risk model for prognosis based upon laboratory parameters in patients with hemorrhagic fever with renal syndrome. (24897398)
2014
39
The epidemic characteristics and changing trend of hemorrhagic fever with renal syndrome in Hubei Province, China. (24658382)
2014
40
Hemorrhagic Fever with Renal Syndrome in the New, and Hantavirus Pulmonary Syndrome in the Old World: paradi(se)gm lost or regained? (24440318)
2014
41
Analysis of incidence and related factors of hemorrhagic fever with renal syndrome in Hebei Province, China. (25000390)
2014
42
Spatiotemporal heterogeneity analysis of hemorrhagic fever with renal syndrome in China using geographically weighted regression models. (25429681)
2014
43
Time-specific ecologic niche models forecast the risk of hemorrhagic fever with renal syndrome in Dongting Lake district, China, 2005-2010. (25184252)
2014
44
Analysis of an outbreak of hemorrhagic fever with renal syndrome in college students in Xi'an, China. (24481251)
2014
45
The spatial analysis on hemorrhagic fever with renal syndrome in Jiangsu province, China based on geographic information system. (25207806)
2014
46
Elevated Soluble CD163 Plasma Levels Are Associated with Disease Severity in Patients with Hemorrhagic Fever with Renal Syndrome. (25392926)
2014
47
Dobrava virus carried by the yellow-necked field mouse Apodemus flavicollis, causing hemorrhagic fever with renal syndrome in Romania. (24746107)
2014
48
Increased Risk of Acute Myocardial Infarction and Stroke During Hemorrhagic Fever with Renal Syndrome: A Self-Controlled Case Series Study. (24398017)
2014
49
Seasonal amplitude of hemorrhagic fever with renal syndrome in China: a call for attention to neglected regions. (24944230)
2014
50
Spatiotemporal transmission dynamics of hemorrhagic fever with renal syndrome in China, 2005-2012. (25412324)
2014

Variations for Hemorrhagic Fever with Renal Syndrome

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Expression for genes affiliated with Hemorrhagic Fever with Renal Syndrome

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Search GEO for disease gene expression data for Hemorrhagic Fever with Renal Syndrome.

Pathways for genes affiliated with Hemorrhagic Fever with Renal Syndrome

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Pathways related to Hemorrhagic Fever with Renal Syndrome according to GeneCards Suite gene sharing:

(show all 47)
idSuper pathwaysScoreTop Affiliating Genes
19.6CRP, IL6, TNF
29.5IL6, TNF, VTN
3
Show member pathways
9.4CD40LG, IFNG, TNF
49.4IFNG, IL6, TNF
59.4IFNG, IL6, TNF
69.4IFNG, IL6, TNF
79.4IFNG, IL6, TNF
8
Show member pathways
9.4B2M, IFNG, TNF
99.3CD40LG, IFNG, VTN
109.3IFNG, IL6, VTN
11
Show member pathways
9.2B2M, HLA-DRB1, IFNG
12
Show member pathways
9.1CD40LG, IFNG, IL6, TNF
139.1IL10, IL6, TNF
149.1IL10, IL6, TNF
159.1IL10, IL6, TNF
169.1IL10, IL6, TNF
179.0HLA-DRB1, HLA-DRB5, IL6, TNF
189.0HLA-DRB1, HLA-DRB5, IL6, TNF
198.9IFNG, IL10, TNF
20
Show member pathways
8.9IFNG, IL10, TNF
218.8CD40LG, IL10, IL6, TNF
228.8CD40LG, IL10, IL6, TNF
238.8IFNG, IL10, IL6
248.7HLA-DRB1, HLA-DRB5, IL10
25
Show member pathways
8.7B2M, HLA-DRB1, HLA-DRB5, IFNG
26
Show member pathways
8.6ALB, CRP, IFNG, IL6, TNF
27
Show member pathways
8.6IFNG, IL10, IL6, TNF
288.6IFNG, IL10, IL6, TNF
298.6IFNG, IL10, IL6, TNF
30
Show member pathways
8.6IFNG, IL10, IL6, TNF
31
Show member pathways
8.6IFNG, IL10, IL6, TNF
32
Show member pathways
8.5HLA-DRB1, HLA-DRB5, IFNG, IL6, TNF
338.5HLA-DRB1, HLA-DRB5, IFNG, IL6, TNF
34
Show member pathways
8.3CD40LG, IFNG, IL10, IL6, TNF
358.3CD40LG, IFNG, IL10, IL6, TNF
368.3B2M, CD40LG, IFNG, IL10, TNF
378.2HLA-DRB1, HLA-DRB5, IFNG, IL10
388.2HLA-DRB1, IFNG, IL10, IL6, TNF
397.9CD163, IFNG, IL10, IL6, TNF
407.9CD163, IFNG, IL10, IL6, TNF
41
Show member pathways
7.7CD40LG, HLA-DRB1, HLA-DRB5, IFNG, IL10, TNF
42
Show member pathways
7.7CD40LG, HLA-DRB1, HLA-DRB5, IFNG, IL10, TNF
437.6HLA-DRB1, HLA-DRB5, IFNG, IL10, IL6, TNF
44
Show member pathways
7.6HLA-DRB1, HLA-DRB5, IFNG, IL10, IL6, TNF
45
Show member pathways
7.1B2M, CD40LG, HLA-DRB1, HLA-DRB5, IFNG, IL10
46
Show member pathways
7.1B2M, CD40LG, HLA-DRB1, HLA-DRB5, IFNG, IL10
47
Show member pathways
6.4B2M, CD40LG, CRP, HLA-DRB1, HLA-DRB5, IFNG

GO Terms for genes affiliated with Hemorrhagic Fever with Renal Syndrome

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Cellular components related to Hemorrhagic Fever with Renal Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1ER to Golgi transport vesicle membraneGO:001250710.0B2M, HLA-DRB1, HLA-DRB5
2endocytic vesicle membraneGO:00306669.7CD163, HLA-DRB1, HLA-DRB5
3MHC class II protein complexGO:00426139.5HLA-DRB1, HLA-DRB5
4external side of plasma membraneGO:00098978.6B2M, CD163, CD40LG, HLA-DRB1, IFNG, IL6
5extracellular regionGO:00055767.0ALB, B2M, CD163, CD40LG, CRP, IFNG
6extracellular spaceGO:00056156.9ALB, B2M, CD40LG, CRP, IFNG, IL10

Biological processes related to Hemorrhagic Fever with Renal Syndrome according to GeneCards Suite gene sharing:

(show all 41)
idNameGO IDScoreTop Affiliating Genes
1epithelial cell proliferation involved in salivary gland morphogenesisGO:006066410.7IL6, TNF
2positive regulation of chemokine productionGO:003272210.6IL6, TNF
3regulation of immunoglobulin secretionGO:005102310.6CD40LG, TNF
4negative regulation of alkaline phosphatase activityGO:001069310.6SEMA4D, TNF
5positive regulation of receptor-mediated endocytosisGO:004826010.5B2M, VTN
6positive regulation of calcidiol 1-monooxygenase activityGO:006055910.4IFNG, TNF
7positive regulation of chemokine biosynthetic processGO:004508010.4IFNG, TNF
8positive regulation of membrane protein ectodomain proteolysisGO:005104410.4IFNG, TNF
9neutrophil apoptotic processGO:000178110.4IFNG, IL6
10negative regulation of lipid storageGO:001088810.3CRP, IL6, TNF
11positive regulation of NF-kappaB transcription factor activityGO:005109210.3CD40LG, IL6, TNF
12positive regulation of vitamin D biosynthetic processGO:006055710.3IFNG, TNF
13positive regulation of protein import into nucleus, translocationGO:003316010.3IFNG, IL6
14antigen processing and presentation of peptide or polysaccharide antigen via MHC class IIGO:000250410.3HLA-DRB1, HLA-DRB5
15endothelial cell apoptotic processGO:007257710.1IL10, TNF
16humoral immune responseGO:000695910.1IFNG, IL6, TNF
17positive regulation of peptidyl-tyrosine phosphorylationGO:005073110.1IL6, SEMA4D, VTN
18cellular response to hepatocyte growth factor stimulusGO:003572910.1IL10, IL6
19negative regulation of cytokine secretion involved in immune responseGO:000274010.1IL10, TNF
20positive regulation of heterotypic cell-cell adhesionGO:003411610.1IL10, TNF
21positive regulation of nitric oxide biosynthetic processGO:004542910.1IFNG, IL6, TNF
22defense response to Gram-positive bacteriumGO:005083010.1B2M, CRP, IL6, TNF
23positive regulation of T cell proliferationGO:004210210.1CD40LG, IFNG, IL6
24positive regulation of vascular smooth muscle cell proliferationGO:190470710.0IL10, TNF
25receptor biosynthetic processGO:003280010.0IL10, TNF
26acute-phase responseGO:000695310.0CD163, CRP, IL6
27response to molecule of bacterial originGO:00022379.8B2M, IL10
28positive regulation of MHC class II biosynthetic processGO:00453489.8IFNG, IL10
29positive regulation of gene expressionGO:00106289.8CRP, IFNG, IL6, TNF
30antigen processing and presentationGO:00198829.8HLA-DRB1, HLA-DRB5, IFNG
31positive regulation of sequence-specific DNA binding transcription factor activityGO:00510919.7IL10, IL6, TNF
32response to glucocorticoidGO:00513849.6IL10, IL6, TNF
33defense response to protozoanGO:00428329.6IFNG, IL10, IL6
34negative regulation of growth of symbiont in hostGO:00441309.6IFNG, IL10, TNF
35interferon-gamma-mediated signaling pathwayGO:00603339.4B2M, HLA-DRB1, HLA-DRB5, IFNG
36T cell costimulationGO:00312959.3CD40LG, HLA-DRB1, HLA-DRB5
37response to drugGO:00424939.1B2M, IFNG, IL10, IL6
38negative regulation of apoptotic processGO:00430669.0ALB, CD40LG, IL10, IL6, SEMA4D
39cellular response to lipopolysaccharideGO:00712229.0B2M, IFNG, IL10, IL6, TNF
40inflammatory responseGO:00069548.7CD163, CD40LG, CRP, IL10, IL6, TNF
41immune responseGO:00069557.1B2M, CD40LG, HLA-DRB1, HLA-DRB5, IFNG, IL10

Molecular functions related to Hemorrhagic Fever with Renal Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051258.3CD40LG, IFNG, IL10, IL6, TNF

Sources for Hemorrhagic Fever with Renal Syndrome

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet