HFRS
MCID: HMR004
MIFTS: 65

Hemorrhagic Fever with Renal Syndrome (HFRS) malady

Infectious diseases, Nephrological diseases categories

Summaries for Hemorrhagic Fever with Renal Syndrome

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A viral infectious disease that is a hemorrhagic fever, located in kidney, has material basis in hantaan virus, has material basis in dobrava-belgrade virus, has material basis in seoul virus, or has material basis in puumala virus, which are carried and transmitted by rodents. the infection has symptom headache, has symptom fever, has symptom muscle pains, has symptom facial flush, has symptom petechiae, has symptom hemorrhagic features, has symptom proteinuria, and has symptom renal failure.

MalaCards: Hemorrhagic Fever with Renal Syndrome, also known as hantavirosis, is related to acute pancreatitis and acute myocardial infarction, and has symptoms including headache, early death/lethality and intracranial/cerebral/meningeal hemorrhage. An important gene associated with Hemorrhagic Fever with Renal Syndrome is HLA-DRB4 (major histocompatibility complex, class II, DR beta 4), and among its related pathways are Rheumatoid arthritis and GRB2:SOS provides linkage to MAPK signaling for Intergrins . The compounds bio 1211 and tc-i 15 have been mentioned in the context of this disorder. Affiliated tissues include kidney, kidney and lung, and related mouse phenotypes are immune system and hematopoietic system.

Wikipedia:63 Hantavirus hemorrhagic fever with renal syndrome (HFRS) is a group of clinically similar illnesses... more...

Aliases & Classifications for Hemorrhagic Fever with Renal Syndrome

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Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 48Orphanet, 56SNOMED-CT, 39NCIt, 34MeSH, 27ICD9CM, 35MESH via Orphanet, 57SNOMED-CT via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Nephrological diseases


Aliases & Descriptions:

hemorrhagic fever with renal syndrome 8 10 60
hantavirosis 48 60
hemorrhagic fever - renal syndrome 48
hemorrhagic nephrosonephritis 8
hemorrhagic fever, russian 8
puumala virus nephropathy 8
hantavirus fever 48
hfrs 8


External Ids:

Disease Ontology8 DOID:11266
NCIt39 C84753
MeSH34 D006480
ICD9CM27 078.6
MESH via Orphanet35 C535630, D006480
SNOMED-CT via Orphanet57 102455002, 364756009
ICD10 via Orphanet26 A98.5+, N08.0*
UMLS via Orphanet61 C0019101, C2930957

Related Diseases for Hemorrhagic Fever with Renal Syndrome

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17GeneCards, 18GeneDecks
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Diseases related to Hemorrhagic Fever with Renal Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 108)
idRelated DiseaseScoreTop Affiliating Genes
1acute pancreatitis30.7ITGAM, GPT
2acute myocardial infarction30.3ITGAM, ITGA2B
3peritonitis30.3B2M, SLPI
4hepatitis b30.3GPT, RNPC3
5myocardial infarction30.3ITGA2B, ITGAM, ITGB3
6hepatitis30.3GPT, VTN
7disseminated intravascular coagulation30.3VTN
8thrombocytopenia30.3SLPI, ITGB3, ITGA2B, CD40LG, GPT
9hemorrhagic disease10.8
10nephropathia epidemica10.7
11korean hemorrhagic fever10.6
12hantavirus pulmonary syndrome10.6
13pancreatitis10.5
14balkan hemorrhagic fever10.4
15hypopituitarism10.4
16image syndrome10.4
17hypertension10.4
18renal hypertension10.4
19diabetic nephropathy10.2
20alport syndrome10.2
21hemophagocytic lymphohistiocytosis10.2
22arteriovenous malformation10.2
23crimean-congo hemorrhagic fever10.2
24west syndrome10.2
25leptospirosis10.2
26orchitis10.2
27balkan nephropathy10.2
28scrub typhus10.2
29metabolic acidosis10.2
30gallbladder disease10.2
31glaucoma10.2
32labyrinthitis10.2
33typhus10.2
34hereditary pancreatitis10.2
35hemorrhagic fever10.0CD40LG
36lupus erythematosus10.0CD40LG
37crohn's disease10.0ITGA4
38vascular disease10.0ITGAM
39antiphospholipid syndrome10.0CD40LG
40influenza10.0RNPC3
41dengue hemorrhagic fever10.0CD40LG
42tuberculosis10.0ITGAM
43myeloid leukemia10.0ITGAM
44toxoplasmosis10.0CD40LG
45connective tissue disease10.0CD40LG
46acquired immunodeficiency syndrome10.0B2M
47diabetic retinopathy10.0VTN, ITGB3
48autoimmune thrombocytopenic purpura10.0ITGB3, ITGA2B
49mixed connective tissue disease10.0RNPC3
50encephalitis10.0ITGA4, ICAM2

Graphical network of the top 20 diseases related to Hemorrhagic Fever with Renal Syndrome:



Diseases related to hemorrhagic fever with renal syndrome

Clinical Features for Hemorrhagic Fever with Renal Syndrome

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8Disease Ontology
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Symptoms:

8 (show all 39)
  • headache
  • early death/lethality
  • intracranial/cerebral/meningeal hemorrhage
  • hypotension
  • chronic arterial hypertension
  • cardiac rhythm disorder/arrhythmia
  • fever
  • muscle pains
  • facial flush
  • petechiae
  • hemorrhagic features
  • proteinuria
  • renal failure
  • abnormal hepatic enzymes/transaminases
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
  • myocardium anomalies/myocarditis
  • hemoptysis
  • renal tubular defect/tubulopathy
  • atelectasia/pulmonary collapse
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • lung/pulmonary infiltrates
  • abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
  • acute abdominal pain/colic
  • photophobia
  • conjunctival injection/chemosis/red eye
  • chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis
  • asthenia/fatigue/weakness
  • interstitial nephropathy
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • myopia
  • transient amaurosis/acute visual trouble
  • hypoproteinemia
  • thrombocytopenia/thrombopenia
  • hyperleukocytosis/leukocytosis
  • articular/joint pain/arthralgia
  • myalgia/muscular pain
  • facial pain/cephalalgia/migraine
  • pollakiuria/polyuria/dysuria/anuria/acute urine retention/oliguria
  • fever/chilling

Drugs & Therapeutics for Hemorrhagic Fever with Renal Syndrome

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Hemorrhagic Fever with Renal Syndrome

Drug clinical trials:

Search ClinicalTrials for Hemorrhagic Fever with Renal Syndrome

Search NIH Clinical Center for Hemorrhagic Fever with Renal Syndrome

Search CenterWatch for Hemorrhagic Fever with Renal Syndrome

Genetic Tests for Hemorrhagic Fever with Renal Syndrome

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Anatomical Context for Hemorrhagic Fever with Renal Syndrome

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Hemorrhagic Fever with Renal Syndrome:

32
Kidney, Lung, T cells, Eye, Testes, Endothelial, B cells, Liver, Pancreas, Heart

FMA organs/tissues related to Hemorrhagic Fever with Renal Syndrome:

14
Kidney

Animal Models for Hemorrhagic Fever with Renal Syndrome or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Hemorrhagic Fever with Renal Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053879.3UBASH3A, ITGA4, ITGAM, ITGB3, ITGA2B, B2M
2MP:00053979.0VTN, ICAM2, UBASH3A, ITGA4, ITGAM, ITGB3

Publications for Hemorrhagic Fever with Renal Syndrome

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Sources:
50PubMed
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Articles related to Hemorrhagic Fever with Renal Syndrome:

(show top 50)    (show all 318)
idTitleAuthorsYear
1
Correction: Investigating the Effects of Food Available and Climatic Variables on the Animal Host Density of Hemorrhagic Fever with Renal Syndrome in Changsha, China. (24058426)
2013
2
Levels of HTNV-specific CD8+ T lymphocytes in PBMC from the patients with hemorrhagic fever with renal syndrome. (21655928)
2013
3
Meteorological factors are associated with hemorrhagic fever with renal syndrome in Jiaonan County, China, 2006-2011. (23793957)
2013
4
Spatial analysis of hemorrhagic fever with renal syndrome in Zibo City, China, 2009-2012. (23840719)
2013
5
Genetic characterization of a new subtype of Hantaan virus isolated from a hemorrhagic fever with renal syndrome (HFRS) epidemic area in Hubei Province, China. (22718221)
2012
6
Acute kidney injury in patients with hemorrhagic fever with renal syndrome caused by Hantaan virus: comparative evaluation by RIFLE and AKIN criteria. (21142962)
2011
7
Hemorrhagic fever with renal syndrome complicated by orchitis. (21847761)
2011
8
HLA-associated hemorrhagic fever with renal syndrome disease progression in slovenian patients. (21775516)
2011
9
Experience with intravenous ribavirin in the treatment of hemorrhagic fever with renal syndrome in Korea. (18977392)
2009
10
Low levels of serum vitronectin associated with clinical phases in patients with hemorrhagic fever with renal syndrome. (19408099)
2009
11
Application of flow microbeads assay in detection of specific antibodies and cytokines in serum from patients with hemorrhagic fever with renal syndrome]. (19257990)
2009
12
Spatiotemporal dynamics of hemorrhagic fever with renal syndrome, Beijing, People's Republic of China. (19961697)
2009
13
Laboratory findings in patients with hemorrhagic fever with renal syndrome]. (15909883)
2005
14
Comparison of virulence of various hantaviruses related to hemorrhagic fever with renal syndrome in newborn mouse model. (15070039)
2004
15
Hemorrhagic fever with renal syndrome: imported or native disease in the Zadar region]. (15011474)
2003
16
Clinicofunctional characteristics of the heart in hemorrhagic fever with renal syndrome]. (12471834)
2002
17
Double trouble: hemorrhagic fever with renal syndrome and leptospirosis. (12030403)
2002
18
Dinara - new natural focus of hemorrhagic fever with renal syndrome in Croatia. (12402400)
2002
19
Epidemiologic characteristics and military implications of hemorrhagic fever with renal syndrome in croatia. (12402401)
2002
20
Sonographic evaluation of gallbladder-wall thickening in hemorrhagic fever with renal syndrome: prediction of disease severity. (11486323)
2001
21
Genetic diversity of hantaviruses associated with hemorrhagic fever with renal syndrome in the far east of Russia. (11074123)
2000
22
Hemorrhagic fever with renal syndrome induced chronic renal dysfunction. (10644233)
1999
23
Changes of T-lymphocyte subsets in patients with hemorrhagic fever with renal syndrome. (8742978)
1996
24
Cross-neutralization of hantaviruses with immune sera from experimentally infected animals and from hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome patients. (7594720)
1995
25
Domestic cases of hemorrhagic fever with renal syndrome in the United States. (7991040)
1994
26
Chronic renal dysfunction in hemorrhagic fever with renal syndrome patients. (7904764)
1993
27
Liver involvement in hemorrhagic fever with renal syndrome. (8104972)
1993
28
An epidemiologic study of hemorrhagic fever with renal syndrome in Bashkirtostan (Russia) and Sweden. (8100119)
1993
29
The Hantaviruses, etiologic agents of hemorrhagic fever with renal syndrome: a possible cause of hypertension and chronic renal disease in the United States. (1350911)
1992
30
Nephropathia epidemica: mild variant of hemorrhagic fever with renal syndrome. (1685202)
1991
31
Hemorrhagic fever with renal syndrome: MR imaging of the kidney. (1971450)
1990
32
Hemorrhagic fever with renal syndrome imported to Hawaii from West Germany. (1974384)
1990
33
Nucleotide sequence of the M genome segment of hemorrhagic fever with renal syndrome virus strain B-1. (2118626)
1990
34
Hemorrhagic fever with renal syndrome in a Canadian serviceman. (1972650)
1990
35
A clinical study of hemorrhagic fever with renal syndrome caused by Seoul virus infection. (2577257)
1989
36
Hemorrhagic fever with renal syndrome in Korea. (2568676)
1989
37
Hemorrhagic fever with renal syndrome in Yugoslavia: antigenic characterization of hantaviruses isolated from Apodemus flavicollis and Clethrionomys glareolus. (2569846)
1989
38
Virion proteins of viruses causing hemorrhagic fever with renal syndrome; monoclonal antibody analysis. (2474668)
1989
39
Hemorrhagic fever with renal syndrome: four decades of research. (2563323)
1989
40
Cats--source of protection or infection? A case-control study of hemorrhagic fever with renal syndrome. (2889355)
1987
41
Isolation of a hantavirus from a severely ill patient with hemorrhagic fever with renal syndrome in Greece. (2890690)
1987
42
Control of laboratory acquired hemorrhagic fever with renal syndrome (HFRS) in Japan. (2889847)
1987
43
Renal damage in hemorrhagic fever with renal syndrome. Measurements of urine and serum lysozyme and urine IgG. (2896107)
1987
44
Comparison of immunofluorescence and hemagglutination inhibition tests and enzyme-linked immunosorbent assay for detection of serum antibody in rats infected with hemorrhagic fever with renal syndrome virus. (2877007)
1986
45
Morphology and morphogenesis of viruses of hemorrhagic fever with renal syndrome (HFRS). I. Some peculiar aspects of the morphogenesis of various strains of HFRS virus. (2984144)
1985
46
Antigenic and genetic properties of viruses linked to hemorrhagic fever with renal syndrome. (2858126)
1985
47
Antigenic differences between two viruses, isolated in Japan and Korea, that cause hemorrhagic fever with renal syndrome. (6207309)
1984
48
Etiologic studies of epidemic hemorrhagic fever (hemorrhagic fever with renal syndrome). (6132949)
1983
49
Other serotypes of hemorrhagic fever with renal syndrome viruses in Europe. (6129496)
1982
50
GEOGRAPHICAL DISTRIBUTION OF HEMORRHAGIC FEVER WITH RENAL SYNDROME. (14196952)
1964

Genetic Variations for Hemorrhagic Fever with Renal Syndrome

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Expression for genes affiliated with Hemorrhagic Fever with Renal Syndrome

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hemorrhagic Fever with Renal Syndrome

Search GEO for disease gene expression data for Hemorrhagic Fever with Renal Syndrome.

Pathways for genes affiliated with Hemorrhagic Fever with Renal Syndrome

About this section
Sources:
29KEGG, 53Reactome, 4Cell Signaling Technology, 12EMD Millipore, 51QIAGEN, 37NCBI BioSystems Database
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Pathways related to Hemorrhagic Fever with Renal Syndrome according to GeneCards/GeneDecks:

(show all 38)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3HLA-DOB
2
Hide members
10.3ITGA2B, ITGB3
310.2ITGA2B, ITGB3, ITGA4
410.2ITGB3, ITGAM, ITGA4
5
Immune response Lectin induced complement pathway
Hide members
10.1VTN, CD93, ITGAM
610.1HLA-DRB4, HLA-DOB, HLA-DRB5
7
Immune response Antigen presentation by MHC class II
Hide members
10.1HLA-DRB4, HLA-DOB, HLA-DRB5
810.1HLA-DRB5, HLA-DOB, HLA-DRB4
910.1HLA-DRB5, HLA-DOB, HLA-DRB4
1010.1HLA-DRB4, HLA-DOB, HLA-DRB5
11
Immune response NFAT in immune response
Hide members
10.1HLA-DRB5, HLA-DOB, HLA-DRB4
12
Immune response ICOS pathway in T-helper cell
Hide members
10.1HLA-DRB4, HLA-DOB, HLA-DRB5
13
Hide members
10.1HLA-DRB4, HLA-DOB, HLA-DRB5
1410.1VTN, ITGAM, ICAM2
1510.1ICAM2, ITGA4, ITGAM
16
Hide members
10.1B2M, ITGA4, ICAM2
17
Hide members
10.1ITGA2B, ITGB3, ITGAM, ITGA4
18
Hide members
10.1ITGA4, ITGAM, ITGB3, ITGA2B
1910.1ITGA4, ITGAM, ITGB3, ITGA2B
20
Hide members
10.1ITGA4, ITGAM, ITGB3, ITGA2B
21
Hide members
10.1ITGA4, ITGAM, ITGB3, ITGA2B
22
Hide members
10.1ITGA4, ITGAM, ITGB3, ITGA2B
23
Hide members
10.0HLA-DRB5, HLA-DOB, HLA-DRB4, CD40LG
2410.0HLA-DRB5, HLA-DOB, HLA-DRB4, ITGAM
2510.0HLA-DRB5, HLA-DOB, HLA-DRB4, ITGAM
269.9ITGA4, ITGAM, ITGB3, ITGA2B, VTN
27
Hide members
9.9ITGA4, ITGAM, ITGB3, ITGA2B, VTN
28
Hide members
9.9ITGA4, ITGAM, ITGB3, ITGA2B, VTN
299.9HLA-DRB5, HLA-DOB, HLA-DRB4, ITGAM, ITGB3
30
Hide members
9.9ICAM2, ITGA4, ITGB3, ITGA2B, VTN
319.9HLA-DRB5, HLA-DRB4, ITGA4, ITGAM, ITGB3, ITGA2B
32
Hide members
9.8HLA-DRB5, HLA-DOB, HLA-DRB4, ITGA4, ITGAM, CD40LG
33
Hide members
9.8ICAM2, ITGA4, ITGAM, ITGB3, ITGA2B, VTN
34
Hide members
9.8HLA-DRB5, HLA-DOB, HLA-DRB4, ITGA4, B2M, CD40LG
35
Hide members
9.7HLA-DRB5, HLA-DOB, HLA-DRB4, ITGA4, ITGAM, ITGB3
36
Hide members
9.7HLA-DRB5, HLA-DOB, HLA-DRB4, ITGA4, ITGAM, ITGB3
379.7CD40LG, ICAM2, HLA-DRB5, HLA-DOB, HLA-DRB4, ITGA4
38
Hide members
9.6ICAM2, HLA-DRB5, HLA-DOB, HLA-DRB4, ITGA4, ITGAM

Compounds for genes affiliated with Hemorrhagic Fever with Renal Syndrome

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Sources:
59Tocris Bioscience, 44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 2BitterDB
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Compounds related to Hemorrhagic Fever with Renal Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 61)
idCompoundScoreTop Affiliating Genes
1bio 12115910.6ITGB3, ITGA2B, ITGA4
2tc-i 155910.6ITGA2B, ITGA4, ITGB3
3leukadherin 15910.6ITGA4, ITGB3, ITGA2B
4a 2869825910.6ITGB3, ITGA4, ITGA2B
5obtustatin5910.6ITGA2B, ITGB3, ITGA4
6rhodostomin4410.6ITGB3, VTN
7lamivudine44 1111.6B2M, SLPI
8hemophan4410.6ITGAM, B2M
9an 694410.6VTN, ITGAM, B2M
10polyacrylonitrile4410.6ITGAM, VTN, B2M
11pmma4410.6VTN, B2M, CD40LG
12iopentol4410.6SLPI, B2M
13cuprophan4410.5ITGAM, VTN, B2M
14tirofiban44 1111.5ITGB3, VTN, ITGA2B, CD40LG
15abciximab44 1111.5ITGB3, VTN, CD40LG, ITGA2B
16sevoflurane44 1111.5B2M, GPT, SLPI
17silicone4410.5CD40LG, RNPC3, VTN
18titanium4410.5ITGB3, VTN, SLPI
19rgd peptide4410.5VTN, ITGA4
20tobramycin4410.4B2M, RNPC3
21phosphorus4410.4GPT, B2M, SLPI
22formaldehyde44 2411.4CD40LG, ITGAM, ITGA2B, B2M
23ivig4410.4GPT, CD40LG, ITGA4
24urea44 11 2412.4VTN, B2M, GPT, SLPI
25aspartate4410.4CD40LG, B2M, GPT, VTN, ITGA4
26hyaluronic acid44 2411.3GPT, CD40LG, SLPI, VTN, B2M
27polysaccharide4410.3B2M, ITGAM, VTN, ICAM2, CD40LG
28aspirin44 49 28 2413.3VTN, CD40LG, ITGB3, ITGAM
29vitamin d4410.3GPT, ITGB3, B2M, SLPI, ITGAM
30rantes4410.3ITGAM, SLPI, CD40LG, ICAM2, ITGA4
31vitamin b124410.3B2M, CD40LG, GPT
32creatinine4410.3GPT, SLPI, ITGAM
33genistein44 28 59 2 11 2415.2SLPI, ITGA4, ITGAM, B2M, CD40LG
34lactate4410.2ITGAM, B2M, CD40LG, GPT, VTN, SLPI
35serine4410.2B2M, ITGA4, ITGA2B, RNPC3, VTN, ITGAM
36pge24410.2CD40LG, B2M, VTN, ITGAM, SLPI
37neopterin4410.2GPT, CD40LG, B2M
38slea4410.2ITGA4, CD40LG
39theophylline44 28 11 2413.2CD40LG, ITGAM, B2M
40cyclosporin a44 28 5912.2GPT, RNPC3, ITGAM, CD40LG, B2M, SLPI
41iron44 2411.1RNPC3, ITGB3, SLPI, GPT, B2M
42dexamethasone44 49 28 1113.1SLPI, VTN, CD40LG, ITGAM, ITGA4, CD93
43vegf4410.1B2M, ITGB3, CD40LG, SLPI, VTN, ITGAM
44cysteine4410.1ITGA2B, VTN, SLPI, CD40LG, ITGAM, B2M
45fibrinogen4410.1GPT, CD40LG, SLPI, VTN, ITGB3, ITGAM
46alanine4410.0SLPI, GPT, CD40LG, B2M, VTN, ITGB3
47heparin44 28 11 2413.0ITGAM, VTN, SLPI, CD40LG, ITGA4
48tyrosine449.7VTN, ITGA4, GPR182, RNPC3, ITGB3, SLPI
49calcium44 49 11 2412.6RNPC3, ITGAM, ICAM2, ITGB3, VTN, SLPI
50adenylate449.6ITGAM, GPR182, RNPC3, CD40LG, GPT

GO Terms for genes affiliated with Hemorrhagic Fever with Renal Syndrome

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Sources:
16Gene Ontology
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Cellular components related to Hemorrhagic Fever with Renal Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule membraneGO:03109210.3ITGA2B, ITGB3
2MHC class II protein complexGO:04261310.2HLA-DRB4, HLA-DOB, HLA-DRB5
3integrin complexGO:00830510.2ITGA4, ITGAM, ITGB3, ITGA2B
4ER to Golgi transport vesicle membraneGO:01250710.1HLA-DRB5, HLA-DRB4, B2M
5alphav-beta3 integrin-vitronectin complexGO:07106210.0VTN, ITGB3
6external side of plasma membraneGO:0098979.9CD40LG, B2M, ITGA2B, ITGAM, ITGA4, HLA-DRB4
7plasma membraneGO:0058869.1ITGAM, ITGA4, HLA-DRB4, HLA-DRB5, ICAM2, ITGB3

Biological processes related to Hemorrhagic Fever with Renal Syndrome according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1regulation of interleukin-4 productionGO:03267310.5HLA-DRB4, HLA-DRB5
2regulation of interleukin-10 secretionGO:200117910.5HLA-DRB4, HLA-DRB5
3immunoglobulin production involved in immunoglobulin mediated immune responseGO:00238110.5HLA-DRB5, HLA-DRB4
4humoral immune response mediated by circulating immunoglobulinGO:00245510.5HLA-DRB5, HLA-DRB4
5leukocyte cell-cell adhesionGO:00715910.4ITGA4, ITGAM, CD40LG
6T-helper 1 type immune responseGO:04208810.4HLA-DRB4, HLA-DRB5
7interferon-gamma-mediated signaling pathwayGO:06033310.4B2M, HLA-DRB4, HLA-DRB5
8integrin-mediated signaling pathwayGO:00722910.4ITGA2B, ITGB3, ITGAM, ITGA4
9cell-matrix adhesionGO:00716010.4VTN, ITGA2B, ITGB3
10inflammatory response to antigenic stimulusGO:00243710.3HLA-DRB5, HLA-DRB4
11regulation of immune responseGO:05077610.3CD40LG, B2M, ITGA4, ICAM2
12antigen processing and presentation of exogenous peptide antigen via MHC class IIGO:01988610.3HLA-DRB5, HLA-DOB, HLA-DRB4
13detection of bacteriumGO:01604510.3HLA-DRB4, HLA-DRB5
14positive regulation of vascular endothelial growth factor receptor signaling pathwayGO:03094910.3VTN, ITGB3
15positive regulation of insulin secretion involved in cellular response to glucose stimulusGO:03577410.2HLA-DRB4, HLA-DRB5
16leukocyte migrationGO:0509009.9ITGA4, ITGAM, ITGB3

Molecular functions related to Hemorrhagic Fever with Renal Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:03239510.2HLA-DRB4, HLA-DOB

Products for genes affiliated with Hemorrhagic Fever with Renal Syndrome

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Sources for Hemorrhagic Fever with Renal Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet