Hemorrhagic Fever with Renal Syndrome disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Aliases & Classifications for Hemorrhagic Fever with Renal Syndrome

Sources:
¹¹Disease Ontology, ¹³DISEASES, ³⁰ICD10, ³¹ICD10 via Orphanet, ³²ICD9CM, ³⁹MeSH, ⁴⁰MESH via Orphanet, ⁴⁵NCIt, ⁵⁴Orphanet, ⁶²SNOMED-CT, ⁶⁸UMLS, ⁶⁹UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Hemorrhagic Fever with Renal Syndrome:

Name: Hemorrhagic Fever with Renal Syndrome ¹¹ ³⁹ ¹³ ⁶⁸

Hantavirosis ⁵⁴ ⁶⁸

Hemorrhagic Fever-Renal Syndrome ⁵⁴

Hemorrhagic Nephrosonephritis ¹¹

Hemorrhagic Fever, Russian ¹¹

Puumala Virus Nephropathy ¹¹

Hantavirus Fever ⁵⁴

Hfrs ¹¹

Characteristics:

Orphanet epidemiological data:

⁵⁴

hantavirosis:
Prevalence: 1-9/1000000 (Europe); Age of onset: All ages; Age of death: any age

Classifications:

MalaCards categories:
Global: Infectious diseases, Rare diseases
Anatomical: Skin diseases, Nephrological diseases

See all MalaCards categories (disease lists)

ICD10: ³¹ ³⁰

Certain infectious and parasitic diseases

Arthropod-borne viral fevers and viral haemorrhagic fevers

Other viral haemorrhagic fevers, not elsewhere classified

Haemorrhagic fever with renal syndrome

Orphanet: ⁵⁴

Rare infectious diseases

External Ids:

Disease Ontology¹¹ DOID:11266

ICD10³⁰ A98.5

ICD9CM³² 078.6

MeSH³⁹ D006480

NCIt⁴⁵ C84753

SNOMED-CT⁶² 102455002, 186701001, 364756009 70826003, more

Orphanet⁵⁴ ORPHA340

MESH via Orphanet⁴⁰ C535630, D006480

UMLS via Orphanet⁶⁹ C0019101, C2930957

ICD10 via Orphanet³¹ A98.5+, N08.0*

UMLS⁶⁸ C0019101

Summaries for Hemorrhagic Fever with Renal Syndrome

Sources:
¹¹Disease Ontology, ³⁶MalaCards
See all MalaCards sources

Disease Ontology:¹¹ A viral infectious disease that is a hemorrhagic fever, located in kidney, has material basis in Hantaan virus, has material basis in Dobrava-Belgrade virus, has material basis in Seoul virus, or has material basis in Puumala virus, which are carried and transmitted by rodents. The infection has symptom headache, has symptom fever, has symptom muscle pains, has symptom facial flush, has symptom petechiae, has symptom hemorrhagic features, has symptom proteinuria, and has symptom renal failure.

MalaCards based summary: Hemorrhagic Fever with Renal Syndrome, also known as hantavirosis, is related to labyrinthitis and hepatitis, and has symptoms including Array, Array and Array. An important gene associated with Hemorrhagic Fever with Renal Syndrome is CD40LG (CD40 Ligand), and among its related pathways are Overview of nanoparticle effects and amb2 Integrin signaling. Affiliated tissues include kidney, kidney and t cells, and related mouse phenotypes are digestive/alimentary and liver/biliary system.

Related Diseases for Hemorrhagic Fever with Renal Syndrome

Sources:
²⁰GeneAnalytics, ²¹GeneCards
See all MalaCards sources

Diseases related to Hemorrhagic Fever with Renal Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 315)

id	Related Disease	Score	Top Affiliating Genes
1	labyrinthitis	29.6	IL10, IL6, TNF
2	hepatitis	29.1	HLA-DRB1, IFNG, IL10, IL6, TNF
3	myocardial infarction	29.1	ALB, CRP, IL10, IL6, TNF
4	korean hemorrhagic fever	11.8
5	nephropathia epidemica	11.3
6	hantavirus pulmonary syndrome	11.3
7	hemorrhagic fever	11.0
8	pancreatitis, hereditary	10.9
9	balkan hemorrhagic fever	10.9
10	vps11-related autosomal recessive hypomyelinating leukodystrophy	10.3	IL6, TNF
11	coloboma of iris	10.3	CRP, IL6
12	dyslexia 5	10.3	IL6, TNF
13	congenital dyserythropoietic anemia	10.3	ALB, TNF
14	aortic atherosclerosis	10.3	IL6, TNF
15	degenerative disc disease	10.3	IL6, TNF
16	gilles de la tourette syndrome	10.3	ALB, B2M
17	bile duct adenocarcinoma	10.3	ALB, CD40LG
18	dextrocardia	10.2	CD40LG, IL6, TNF
19	ethmoid sinus schneiderian papilloma	10.2	B2M, CD40LG, IL6
20	unilateral multicystic dysplastic kidney	10.2	CRP, IL6, TNF
21	mineral metabolism disease	10.2	CD40LG, IL6, TNF
22	joint disorders	10.2	CRP, IL6, TNF
23	cicatricial lagophthalmos	10.2	CRP, IL6, TNF
24	benign neonatal seizures	10.2	CRP, IL6, TNF
25	glycogen storage disease viii	10.2	B2M, CD40LG, CRP
26	colloid adenoma	10.2	ALB, CD40LG
27	tall cell variant papillary carcinoma	10.2	B2M, CD40LG, IL6
28	neuropathy	10.2	CRP, IL6, TNF
29	autoimmune disease of central nervous system	10.2	CRP, IL6, TNF
30	retinal degeneration	10.2	CD40LG, CRP, IL6
31	functional gastric disease	10.2	CD40LG, CRP, TNF
32	pancreas lymphoma	10.2	CRP, IL6, TNF
33	uterine adnexa cancer	10.2	CD40LG, IL6, TNF
34	blepharochalasis	10.2	CRP, IL6, TNF
35	cutaneous sclerosis	10.2	CRP, IL6
36	retinitis pigmentosa 51	10.2	CRP, IL6, TNF
37	estrogen excess	10.2	ALB, CD40LG
38	chondroma	10.2	CRP, IL6, TNF
39	angiomatosis, diffuse corticomeningeal, of divry and van bogaert	10.2	HLA-DRB1, IL6, TNF
40	celiac disease	10.2	CD40LG, CRP, TNF
41	limb ischemia	10.2	CRP, IL6, TNF
42	diabetic encephalopathy	10.2	CRP, IL6, TNF
43	cranial nerve palsy	10.2	B2M, CRP, TNF
44	neovascular glaucoma	10.2	CRP, IL6, TNF
45	pseudohypoparathyroidism	10.2	B2M, CD40LG, HLA-DRB1
46	bilateral parasagittal parieto-occipital polymicrogyria	10.2	HLA-DRB1, TNF
47	endobronchial leiomyoma	10.2	CD40LG, CRP, TNF
48	motility-related diarrhea	10.2	HLA-DRB1, IL6, TNF
49	haemonchiasis	10.2	CD40LG, CRP, TNF
50	angiokeratoma	10.2	ALB, B2M, CD40LG

Graphical network of the top 20 diseases related to Hemorrhagic Fever with Renal Syndrome:

Symptoms & Phenotypes for Hemorrhagic Fever with Renal Syndrome

Sources:
¹¹Disease Ontology, ⁴¹MGI, ⁵⁴Orphanet, ⁶⁴The Human Phenotype Ontology
See all MalaCards sources

Symptoms:

¹¹ (show all 8)

• headache
• fever
• muscle pains
• facial flush

• petechiae
• hemorrhagic features
• proteinuria
• renal failure

Human phenotypes related to Hemorrhagic Fever with Renal Syndrome:

⁵⁴ ⁶⁴ (show all 32)

id	Description	Orphanet Frequency	HPO Source Accession
1	renal insufficiency⁶⁴ ⁵⁴	Frequent (79-30%)	HP:0000083
2	abnormality of the renal tubule⁵⁴	Frequent (79-30%)
3	proteinuria⁶⁴ ⁵⁴	Frequent (79-30%)	HP:0000093
4	conjunctivitis⁶⁴ ⁵⁴	Frequent (79-30%)	HP:0000509
5	myopia⁶⁴ ⁵⁴	Occasional (29-5%)	HP:0000545
6	photophobia⁶⁴ ⁵⁴	Frequent (79-30%)	HP:0000613
7	hypertension⁶⁴ ⁵⁴	Occasional (29-5%)	HP:0000822
8	abnormality of the myocardium⁶⁴ ⁵⁴	Occasional (29-5%)	HP:0001637
9	abnormality of the pericardium⁶⁴ ⁵⁴	Occasional (29-5%)	HP:0001697
10	thrombocytopenia⁶⁴ ⁵⁴	Frequent (79-30%)	HP:0001873
11	fever⁶⁴ ⁵⁴	Very frequent (99-80%)	HP:0001945
12	tubulointerstitial abnormality⁶⁴ ⁵⁴	Frequent (79-30%)	HP:0001969
13	leukocytosis⁶⁴ ⁵⁴	Frequent (79-30%)	HP:0001974
14	abdominal pain⁶⁴ ⁵⁴	Frequent (79-30%)	HP:0002027
15	migraine⁶⁴ ⁵⁴	Frequent (79-30%)	HP:0002076
16	respiratory insufficiency⁶⁴ ⁵⁴	Frequent (79-30%)	HP:0002093
17	hemoptysis⁶⁴ ⁵⁴	Occasional (29-5%)	HP:0002105
18	pulmonary infiltrates⁶⁴ ⁵⁴	Frequent (79-30%)	HP:0002113
19	intracranial hemorrhage⁶⁴ ⁵⁴	Occasional (29-5%)	HP:0002170
20	pleural effusion⁶⁴ ⁵⁴	Frequent (79-30%)	HP:0002202
21	gastrointestinal hemorrhage⁶⁴ ⁵⁴	Occasional (29-5%)	HP:0002239
22	hypotension⁶⁴ ⁵⁴	Occasional (29-5%)	HP:0002615
23	arthralgia⁶⁴ ⁵⁴	Frequent (79-30%)	HP:0002829
24	elevated hepatic transaminases⁶⁴ ⁵⁴	Frequent (79-30%)	HP:0002910
25	hypoproteinemia⁶⁴ ⁵⁴	Frequent (79-30%)	HP:0003075
26	myalgia⁶⁴ ⁵⁴	Frequent (79-30%)	HP:0003326
27	arrhythmia⁶⁴ ⁵⁴	Occasional (29-5%)	HP:0011675
28	subconjunctival hemorrhage⁶⁴ ⁵⁴	Frequent (79-30%)	HP:0011896
29	fatigue⁶⁴ ⁵⁴	Very frequent (99-80%)	HP:0012378
30	oliguria⁶⁴ ⁵⁴	Frequent (79-30%)	HP:0100520
31	amaurosis fugax⁶⁴ ⁵⁴	Occasional (29-5%)	HP:0100576
32	atelectasis⁶⁴ ⁵⁴	Frequent (79-30%)	HP:0100750

MGI Mouse Phenotypes related to Hemorrhagic Fever with Renal Syndrome according to GeneCards Suite gene sharing:

⁴¹

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	digestive/alimentary	MP:0005381	8.6	ALB, B2M, IFNG, IL10, IL6, TNF
2	liver/biliary system	MP:0005370	8.5	ALB, B2M, IFNG, IL10, IL6, TNF
3	neoplasm	MP:0002006	8.5	ALB, B2M, IFNG, IL10, IL6, TNF
4	endocrine/exocrine gland	MP:0005379	8.4	ALB, B2M, CD40LG, IFNG, IL10, IL6
5	cardiovascular system	MP:0005385	7.6	B2M, CD163, CD40LG, CRP, IFNG, IL10
6	immune system	MP:0005387	7.5	B2M, CD163, CD40LG, CRP, IFNG, IL10
7	hematopoietic system	MP:0005397	7.5	B2M, CD163, CD40LG, IFNG, IL10, IL6
8	skeleton	MP:0005390	7.4	CD40LG, HLA-DRB5, IFNG, IL10, IL6, SEMA4D
9	homeostasis/metabolism	MP:0005376	6.7	ALB, B2M, CD163, CD40LG, CRP, IFNG

Drugs & Therapeutics for Hemorrhagic Fever with Renal Syndrome

Sources:
¹BitterDB, ⁴ClinicalTrials, ⁷Cochrane Library, ¹⁰DGIdb, ¹⁴DrugBank, ²⁹HMDB, ³³IUPHAR, ⁵⁰Novoseek, ⁵⁶PharmGKB
See all MalaCards sources

Drugs for Hemorrhagic Fever with Renal Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)

id

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Antibodies

Phase 3

6394

2

Vaccines

Phase 3, Phase 2, Phase 1

6611

3

Immunoglobulins

Phase 3

6394

4

Epinephrine

approved, vet_approved

Phase 2, Phase 1

985

51-43-4

5816

Synonyms:

(-)-(R)-Epinephrine

(-)-3,4-Dihydroxy-a-[2-(methylamino)ethyl]benzyl alcohol

(-)-3,4-Dihydroxy-alpha-((methylamino)methyl)benzyl alcohol

(-)-3,4-Dihydroxy-alpha-[2-(methylamino)ethyl]benzyl alcohol

(-)-3,4-dihydroxy-a-[(methylamino)methyl]-Benzyl alcohol

(-)-3,4-dihydroxy-alpha-[(methylamino)methyl]-Benzyl alcohol

(-)-Adrenalin

(-)-Adrenaline

(-)-Epinephrine

(-)-R-Epinephrine

(R)-(-)-Adnephrine

(R)-(-)-Adrenaline

(R)-(-)-Epinephrine

(R)-(-)-Epirenamine

(R)-(−)-adrenaline

(R)-4-[1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol

(R)-4-[1-hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol

(R)-Adrenaline

(R)-Epinephrine

(−)-adrenaline

02252_FLUKA

1-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol

1-Adrenalin

1-Epinephrine

4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-benzenediol

4-(1-hydroxy-2-methylamino-ethyl)benzene-1,2-diol

4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol

4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol

4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol

51-43-4

51-43-4 (FREE BASE)

51028-73-0

A0173

AC-13188

AC1L1L7B

ADR ADRENALINE

ADROP

AI3-19015

Adnephrine

Adrenal

Adrenalin

Adrenalin (TN)

Adrenalin in Oil

Adrenalin-Medihaler

Adrenalina

Adrenalina [DCIT]

Adrenaline

Adrenaline (JP15)

Adrenaline/Epinephrine

Adrenalinum

Adrenamine

Adrenan

Adrenapax

Adrenasol

Adrenatrate

Adrenine

Adrenodis

Adrenohorma

Adrenosan

Adrenutol

Adrin

Adrine

Ana-Guard

Ana-Kit

Antiasthmatique

Asmatane Mist

Asthma meter mist

Asthma-nefrin

Asthmahaler Mist

Asthmanefrin

Astmahalin

Astminhal

BIDD:GT0119

Balmadren

Bernarenin

Biorenine

Bosmin

Brevirenin

Bronkaid

Bronkaid Mist

Bronkaid Suspension Mist

Bupivacaine Hcl and Epinephrine

C00788

CCRIS 4812

CHEBI:28918

CHEMBL679

CID5816

Chelafrin

Citanest Forte

Corisol

D-Epifrin

D-Epinephrine

D00095

DB00668

Drenamist

Dylephrin

Dyspne-Inhal

E4250_SIGMA

EINECS 200-098-7

EPI E Z PEN JR

EPIPEN E Z PEN

EPIPEN JR

Epi EZ Pen Jr

Epifrin

Epiglaufrin

Epinefrin

Epinefrin [Czech]

Epinefrina

Epinefrina [INN-Spanish]

Epinephran

Epinephrin

Epinephrine

Epinephrine (USP)

Epinephrine (USP/INN)

Epinephrine [USAN:INN:JAN]

Epinephrine hydrochloride

Epinephrinum

Epinephrinum [INN-Latin]

Epipen

Epipen (TN)

Epipen Auto-Injector

Epipen EZ Pen

Epipen Jr.

Epipen Jr. Auto-Injector

Epirenamine

Epirenan

Epirenin

Epitrate

Eppy

Esphygmogenina

Exadrin

Glaucon

Glaucosan

Glauposine

Glycirenan

HSCI1_000215

HSDB 4289

Haemostasin

Haemostatin

Hektalin

Hemisine

Hemostasin

Hemostatin

Hypernephrin

Hyporenin

IOP

Intranefrin

Iontocaine

Isoptoepinal

Kidoline

L-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol

L-Adrenaline

L-Adrenaline Base

L-Epinehphrine

L-Epinephrine

L-Epirenamine

L-Methylaminoethanolcatechol

L-epinephrine

LS-156

Levo-Methylaminoethanolcatechol

Levoadrenaline

Levoepinephrine

Levorenen

Levorenin

Levorenine

Levoreninum

Lopac-E-4642

Lyodrin

Lyophrin

Medihaler-Epi

Metanephrin

Methylaminoethanolcatechol

Methylarterenol

Micronefrin

Micronephrine

MolPort-002-051-368

Mucidrina

Myosthenine

Mytrate

NCGC00015417-01

NCGC00142615-01

NCGC00142615-03

NCGC00142615-04

NCGC00142615-05

NCGC00142615-06

NCGC00142615-07

NSC 62786

NSC62786

Nephridine

Nieraline

PDSP1_001120

PDSP2_001104

Paranephrin

Primatene

Primatene Mist

R-(-)-Epinephrine

R-Adrenaline

RCRA waste no. P042

Racemic Epinephrine

Racepinephrine

Rcra waste number P042

Renagladin

Renaglandin

Renaglandulin

Renaleptine

Renalina

Renoform

Renostypricin

Renostypticin

Renostyptin

SMP1_000227

ST069368

SUS-PHRINE SULFITE-FREE

Scurenaline

Septocaine

Simplene

Sindrenina

Soladren

Sphygmogenin

Stryptirenal

Styptirenal

Supracapsulin

Supradin

Supranefran

Supranephrane

Supranephrine

Supranol

Suprarenaline

Suprarenin

Suprel

Surenine

Surrenine

Sus-Phrine

Sus-phrine

Susphrine

Sympathin I

Takamina

Takamine

Tokamina

Tonogen

Twinject

Twinject 0.15

Twinject 0.3

Twinject 0.30

UNII-YKH834O4BH

Vaponefrin

Vasoconstrictine

Vasoconstrictor

Vasodrine

Vasoton

Vasotonin

adrenaline

bmse000316

d-Adrenaline

epinephrine

l-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol

l-Adrenalin

l-Adrenaline

l-Epinephine

l-Epinephrine (synthetic)

l-Epirenamine

l-Methylaminoethanolcatechol

levoepinephrine

nchembio747-comp9

5

Ribavirin

approved

Phase 2

1003

36791-04-5

37542

Synonyms:

1-.beta.-D-Ribofuranosyl-1,2,4-triazolo-3-carboxamide

1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazole-3-carboxamide

1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-1,2,4-triazole-3-carboxamide

1-beta-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide

1-beta-D-Ribofuranosyl-1H-1,2,4-triazole-3-carboxamide

1-beta-D-ribofuranosyl-1-H-1,2,4-triazole-3-carboxamide

36791-04-5

437710-49-1

66510-90-5

AA-504/07617051

AB00430481

AC1L1XXZ

AC1Q1IDC

AC1Q4ZGS

AKOS001715163

BB_NC-0567

BPBio1_001195

BRN 0892462

BSPBio_001085

BSPBio_003352

C-Virin

CHEMBL1643

CID37542

Copegus

Copegus (TN)

Cotronak

D00423

DB00811

DRG-0028

DivK1c_000782

Drug: Ribavirin

EU-0101063

FT-0082885

HMS2090L15

HMS2094O09

HMS502H04

HSDB 6513

ICN-1229

IDI1_000782

KBio1_000782

KBio2_002328

KBio2_004896

KBio2_007464

KBio3_002854

KBioGR_001804

KBioSS_002331

KS-1104

LS-1241

Lopac0_001063

MLS000028486

MLS002222317

MolPort-002-507-104

MolPort-002-885-856

NCGC00090726-01

NCGC00090726-03

NCGC00090726-04

NCGC00090726-05

NCGC00090726-06

NCGC00090726-07

NINDS_000782

NSC 163039

NSC163039

Prestwick3_000993

R 9644

R-964

R9644_SIGMA

RBV

RG-964

RIBAV

RTC

RTCA

RTP

Ravanex

Rebetol

Rebetol (TN)

Rebetron

Rebretron

Ribacine

Ribamide

Ribamidil

Ribamidyl

Ribasphere

Ribasphere (TN)

Ribav

Ribavirin

Ribavirin (JAN/USP/INN)

Ribavirin Capsules

Ribavirin Triphosphate

Ribavirin [USAN:INN]

Ribavirin-TP

Ribavirina

Ribavirina [INN-Spanish]

Ribavirine

Ribavirine [INN-French]

Ribavirinum

Ribavirinum [INN-Latin]

Ribovirin

Ro 20-9963/000

Ro-20-9963

S2504_Selleck

SCH 18908

SMP1_000261

SMR000058315

SPECTRUM1503938

SR-01000076112-3

Spectrum3_001876

Spectrum4_001252

Spectrum5_002075

Spectrum_001826

Tribavirin

UNII-49717AWG6K

Varazid

Vilona

Viramid

Viramide

Virazid

Virazide

Virazole

Virazole (Ribavirin) Inhalation Solution

Virazole (TN)

Virazole 5'-triphosphate

ZINC01035331

ribavirin

6

Epinephryl borate

Phase 2, Phase 1

985

7

Racepinephrine

Phase 2, Phase 1

985

8

Antiviral Agents

Phase 2

9967

9

Antimetabolites

Phase 2

12054

10

Anti-Infective Agents

Phase 2

22062

Interventional clinical trials:

id	Name	Status	NCT ID	Phase
1	Study to Evalutate Long-term Immunity of Hantavax in High Risk Population of HFRS	Completed	NCT02360514	Phase 3
2	Phase 2a Immunogenicity Study of Hantaan/Puumala Virus DNA Vaccine for Prevention of Hemorrhagic Fever	Active, not recruiting	NCT02116205	Phase 2
3	Ribavirin for Hemorrhagic Fever With Renal Syndrome	Enrolling by invitation	NCT00623168	Phase 2
4	Ribavirin for Hemorrhagic Fever With Renal Syndrome in Germany	Withdrawn	NCT00868946	Phase 2
5	Palifermin in Preventing Oral Mucositis Caused by Chemotherapy and/or Radiation Therapy in Young Patients Undergoing Stem Cell Transplant	Withdrawn	NCT00728585	Phase 2
6	Study to Evaluate the Safety, Tolerability, and Immunogenicity of Hantaan and Puumala Virus DNA Vaccines	Completed	NCT01502345	Phase 1
7	Diagnostic of Puumala Virus Infection in France	Recruiting	NCT02455375
8	Cohort of Patients Infected by an Arbovirus	Recruiting	NCT01099852
9	Phenotyping IBS: Perceptions and Modulations of Visceral Sensations	Recruiting	NCT02693730

Search NIH Clinical Center for Hemorrhagic Fever with Renal Syndrome

Cochrane evidence based reviews: hemorrhagic fever with renal syndrome

Genetic Tests for Hemorrhagic Fever with Renal Syndrome

Anatomical Context for Hemorrhagic Fever with Renal Syndrome

Sources:
¹⁷FMA, ³⁶MalaCards
See all MalaCards sources

MalaCards organs/tissues related to Hemorrhagic Fever with Renal Syndrome:

³⁶

Kidney, T cells, Testes, Skin, B cells, Endothelial, Neutrophil

FMA organs/tissues related to Hemorrhagic Fever with Renal Syndrome:

¹⁷

Kidney

Publications for Hemorrhagic Fever with Renal Syndrome

Sources:
⁵⁷PubMed
See all MalaCards sources

Articles related to Hemorrhagic Fever with Renal Syndrome:

(show top 50) (show all 370)

id	Title	Authors	Year
1	Lack of association between integrin I+vI^3 gene polymorphisms and hemorrhagic fever with renal syndrome in Han Chinese from Hubei, China. (28190175)	Chen X.P.... Hou W.	2017
2	Prevalence of hemorrhagic fever with renal syndrome in Qingdao City, China, 2010-2014. (27786303)	Jiang F.... Yu X.J.	2016
3	Phylogeographic analysis of hemorrhagic fever with renal syndrome patients using multiplex PCR-based next generation sequencing. (27221218)	Kim W.K.... Song J.W.	2016
4	History of incomplete vaccination may associate with occurrence of hemorrhagic fever with renal syndrome with relieved clinical symptoms. (26636561)	Chen Y.... Zhao Y.	2016
5	Changes in Plasma Adiponectin Concentrations in Patients With Hemorrhagic Fever With Renal Syndrome: An Observational Prospective Study. (26871804)	DU H.... Jiang H.	2016
6	Time Series Analysis of Hemorrhagic Fever with Renal Syndrome: A Case Study in Jiaonan County, China. (27706256)	Li S.... Liu Q.	2016
7	Epidemiological analysis of hemorrhagic fever with renal syndrome in China with the seasonal-trend decomposition method and the exponential smoothing model. (27976704)	Ke G.... Yang D.	2016
8	Prevalence of hemorrhagic fever with renal syndrome in Yiyuan County, China, 2005-2014. (26852019)	Wang T.... Zhai S.	2016
9	The assessment of Hantaan virus-specific antibody responses after the immunization program for hemorrhagic fever with renal syndrome in northwest China. (27824286)	Li Z.... Chen L.	2016
10	Spatio-Temporal Pattern and Influencing Factors of Hemorrhagic Fever with Renal Syndrome (HFRS) in Hubei Province (China) between 2005 and 2014. (28030550)	Ge L.... Huo X.	2016
11	Hemorrhagic Fever with Renal Syndrome: Pathogenesis and Clinical Picture. (26870699)	Jiang H.... Bai X.F.	2016
12	Corrigendum: Hemorrhagic Fever with Renal Syndrome: Pathogenesis and Clinical Picture. (27981038)	Jiang H.... Bai X.F.	2016
13	Genovariation Study of Hantavirus in Main Endemic Areas of Hemorrhagic Fever with Renal Syndrome in Hebei Province, China. (27442527)	Li Q.... Xu Y.	2016
14	Construction of a Seasonal Difference-Geographically and Temporally Weighted Regression (SD-GTWR) Model and Comparative Analysis with GWR-Based Models for Hemorrhagic Fever with Renal Syndrome (HFRS) in Hubei Province (China). (27801870)	Ge L.... Huo X.	2016
15	Effects of Humidity Variation on the Hantavirus Infection and Hemorrhagic Fever with Renal Syndrome Occurrence in Subtropical China. (26711521)	Xiao H.... Tian H.Y.	2016
16	Clinical characterization of two severe cases of hemorrhagic fever with renal syndrome (HFRS) caused by hantaviruses Puumala and Dobrava-Belgrade genotype Sochi. (27842513)	KrautkrAomer E.... Zeier M.	2016
17	Molecular Diagnosis of Hemorrhagic Fever with Renal Syndrome Caused by Puumala Virus. (26962084)	Lagerqvist N.... KlingstrAPm J.	2016
18	Hemorrhagic Fever with Renal Syndrome, Zibo City, China, 2006-2014. (26812444)	Wang L.... Yu X.J.	2016
19	Cytokine response to Hantaan virus infection in patients with hemorrhagic fever with renal syndrome. (27943332)	Guo J.... Zou Y.	2016
20	HMGB-1 as a novel predictor of disease severity and prognosis in patients with hemorrhagic fever with renal syndrome. (25944988)	DU H.... Wang P.	2015
21	Letter on the article "An hemorrhagic fever with renal syndrome revealing a leptospirosis". (26160283)	Joob B.... Wiwanitkit V.	2015
22	Correction: Spatiotemporal Transmission Dynamics of Hemorrhagic Fever with Renal Syndrome in China, 2005-2012. (25799067)		2015
23	Changes in rodent abundance and weather conditions potentially drive hemorrhagic fever with renal syndrome outbreaks in Xi'an, China, 2005-2012. (25822936)	Tian H.Y.... Xu B.	2015
24	Puumala Hantavirus-Induced Hemorrhagic Fever with Renal Syndrome Must Be Considered across the Borders of Nephrology to Avoid Unnecessary Diagnostic Procedures. (26650941)	Kitterer D.... Latus J.	2015
25	Modeling and predicting hemorrhagic Fever with renal syndrome trends based on meteorological factors in hu county, china. (25875211)	Xiao D.... Xu Z.	2015
26	Comparison of Two Hybrid Models for Forecasting the Incidence of Hemorrhagic Fever with Renal Syndrome in Jiangsu Province, China. (26270814)	Wu W.... Zhou B.	2015
27	Acalculous cholecystitis and hemorrhagic fever with renal syndrome. (26139306)	Joob B.... Wiwanitkit V.	2015
28	Long-term persistence of anti-hantavirus antibodies in sera of patients undergoing hemorrhagic fever with renal syndrome and subjects vaccinated against the disease. (26654580)	Zheng Y.... Wang J.J.	2015
29	Elevated serum levels of decoy receptor 3 are associated with disease severity in patients with hemorrhagic fever with renal syndrome. (25647584)	Dong Y.... Xie M.	2015
30	Acalculous cholecystitis and hemorrhagic fever with renal syndrome. (26790561)	Joob B.... Wiwanitkit V.	2015
31	Effects of Climate and Rodent Factors on Hemorrhagic Fever with Renal Syndrome in Chongqing, China, 1997-2008. (26193359)	Bai Y.... Liu Q.	2015
32	Community Acquired Severe Acute Kidney Injury Caused by Hantavirus-Induced Hemorrhagic Fever with Renal Syndrome Has a Favorable Outcome. (26139246)	Outinen T.K.... Mustonen J.	2015
33	Hemorrhagic fever with renal syndrome-related encephalopathy: magnetic resonance imaging findings. (26362353)	Ku M.C.... Seol H.Y.	2015
34	Using autoregressive integrated moving average model to predict the incidence of hemorrhagic fever with renal syndrome in Zibo, China, 2004-2014. (26370428)	Wang T.... Zhai S.	2015
35	Acalculous cholecystitis associated with hemorrhagic fever with renal syndrome: a case report. (25982259)	Nicolas J.B.	2015
36	Upregulation of IFN-I^ and IL-12 is associated with a milder form of hantavirus hemorrhagic fever with renal syndrome. (24942310)	Khaiboullina S.F.... Rizvanov A.A.	2014
37	Increased risk for lymphoma following hemorrhagic fever with renal syndrome. (24965350)	KlingstrAPm J.... Ljunggren H.G.	2014
38	Early indicators of severity and construction of a risk model for prognosis based upon laboratory parameters in patients with hemorrhagic fever with renal syndrome. (24897398)	DU H.... Bai X.F.	2014
39	The epidemic characteristics and changing trend of hemorrhagic fever with renal syndrome in Hubei Province, China. (24658382)	Zhang Y.H.... Yang Z.Q.	2014
40	Hemorrhagic Fever with Renal Syndrome in the New, and Hantavirus Pulmonary Syndrome in the Old World: paradi(se)gm lost or regained? (24440318)	Clement J.... Van Ranst M.	2014
41	Analysis of incidence and related factors of hemorrhagic fever with renal syndrome in Hebei Province, China. (25000390)	Li Q.... Xu Y.	2014
42	Spatiotemporal heterogeneity analysis of hemorrhagic fever with renal syndrome in China using geographically weighted regression models. (25429681)	Li S.... Liu Q.	2014
43	Time-specific ecologic niche models forecast the risk of hemorrhagic fever with renal syndrome in Dongting Lake district, China, 2005-2010. (25184252)	Liu H.N.... Xiao H.	2014
44	Analysis of an outbreak of hemorrhagic fever with renal syndrome in college students in Xi'an, China. (24481251)	Ma C.... Yu P.	2014
45	The spatial analysis on hemorrhagic fever with renal syndrome in Jiangsu province, China based on geographic information system. (25207806)	Bao C.... Peng Z.	2014
46	Elevated Soluble CD163 Plasma Levels Are Associated with Disease Severity in Patients with Hemorrhagic Fever with Renal Syndrome. (25392926)	Wang J.... Wang P.	2014
47	Dobrava virus carried by the yellow-necked field mouse Apodemus flavicollis, causing hemorrhagic fever with renal syndrome in Romania. (24746107)	Panculescu-Gatej R.I.... Ceianu C.S.	2014
48	Increased Risk of Acute Myocardial Infarction and Stroke During Hemorrhagic Fever with Renal Syndrome: A Self-Controlled Case Series Study. (24398017)	Connolly-Andersen A.M.... Ahlm C.	2014
49	Seasonal amplitude of hemorrhagic fever with renal syndrome in China: a call for attention to neglected regions. (24944230)	Xu Z.... Tong S.	2014
50	Spatiotemporal transmission dynamics of hemorrhagic fever with renal syndrome in China, 2005-2012. (25412324)	Zhang W.Y.... Li C.Y.	2014

Genes related to Hemorrhagic Fever with Renal Syndrome

Sources:
¹³DISEASES, ²¹GeneCards
See all MalaCards sources

Genes related to Hemorrhagic Fever with Renal Syndrome:

(show all 13)

- Elite gene

- Cancer Census gene in COSMIC

id	Symbol	Description	Score	Implication
1	CD40LG	CD40 Ligand	35.22	DISEASES inferred ¹³ GeneCards inferred via : Disorders, Publications (show sections)
2	TNF	Tumor Necrosis Factor	33.41	DISEASES inferred ¹³ GeneCards inferred via : Disorders, Publications (show sections)
3	CRP	C-Reactive Protein	33.16	DISEASES inferred ¹³ GeneCards inferred via : Disorders, Publications (show sections)
4	IL6	Interleukin 6	33.10	DISEASES inferred ¹³ GeneCards inferred via : Disorders, Publications (show sections)
5	B2M	Beta-2-Microglobulin	32.81	DISEASES inferred ¹³ GeneCards inferred via : Disorders, Publications (show sections)
6	SEMA4D	Semaphorin 4D	32.76	DISEASES inferred ¹³ GeneCards inferred via : Disorders, Publications (show sections)
7	VTN	Vitronectin	32.49	DISEASES inferred ¹³ GeneCards inferred via : Disorders, Publications (show sections)
8	HLA-DRB1	Major Histocompatibility Complex, Class II, DR Beta 1	32.39	DISEASES inferred ¹³ GeneCards inferred via : Disorders, Publications (show sections)
9	ALB	Albumin	32.33	DISEASES inferred ¹³ GeneCards inferred via : Disorders, Publications (show sections)
10	HLA-DRB5	Major Histocompatibility Complex, Class II, DR Beta 5	32.12	DISEASES inferred ¹³ GeneCards inferred via : Disorders, Publications (show sections)
11	CD163	CD163 Molecule	31.99	DISEASES inferred ¹³ GeneCards inferred via : Disorders, Publications (show sections)
12	IL10	Interleukin 10	31.94	DISEASES inferred ¹³ GeneCards inferred via : Disorders, Publications (show sections)
13	IFNG	Interferon Gamma	31.60	DISEASES inferred ¹³ GeneCards inferred via : Disorders, Publications (show sections)

Variations for Hemorrhagic Fever with Renal Syndrome

Expression for genes affiliated with Hemorrhagic Fever with Renal Syndrome

Sources:
¹⁸Gene Expression Omnibus DataSets
See all MalaCards sources

Search GEO for disease gene expression data for Hemorrhagic Fever with Renal Syndrome.

Pathways for genes affiliated with Hemorrhagic Fever with Renal Syndrome

Sources:
³Cell Signaling Technology, ³⁴KEGG, ⁴²NCBI BioSystems Database, ⁵⁵PathCards, ⁵⁸QIAGEN, ⁵⁹R&D Systems, ⁶⁰Reactome, ⁶⁵Thomson Reuters
See all MalaCards sources

Pathways related to Hemorrhagic Fever with Renal Syndrome according to GeneCards Suite gene sharing:

(show all 47)

id	Super pathways	Score	Top Affiliating Genes
1	Overview of nanoparticle effects⁴²	9.6	CRP, IL6, TNF
2	amb2 Integrin signaling⁴²	9.5	IL6, TNF, VTN
3	Calcineurin-regulated NFAT-dependent transcription in lymphocytes⁴² Show member pathways Calcium signaling in the CD4+ TCR pathway⁴²	9.4	CD40LG, IFNG, TNF
4	Transcription_Role of VDR in regulation of genes involved in osteoporosis⁶⁵	9.4	IFNG, IL6, TNF
5	Development and heterogeneity of the ILC family⁴²	9.4	IFNG, IL6, TNF
6	Spinal Cord Injury⁴²	9.4	IFNG, IL6, TNF
7	Photodynamic therapy-induced AP-1 survival signaling.⁴²	9.4	IFNG, IL6, TNF
8	Downstream signaling in naive CD8+ T cells⁴² Show member pathways Ras signaling in the CD4+ TCR pathway⁴²	9.4	B2M, IFNG, TNF
9	Inflammatory Response Pathway⁴²	9.3	CD40LG, IFNG, VTN
10	Senescence and Autophagy in Cancer⁴²	9.3	IFNG, IL6, VTN
11	IL12-mediated signaling events⁴² Show member pathways Immune response IL-12-induced IFN-gamma production⁶⁵	9.2	B2M, HLA-DRB1, IFNG
12	Photodynamic therapy-induced NF-kB survival signaling⁴² Show member pathways Immune response MIF-mediated glucocorticoid regulation⁶⁵	9.1	CD40LG, IFNG, IL6, TNF
13	IL-10 Pathway⁵⁸	9.1	IL10, IL6, TNF
14	Pertussis³⁴	9.1	IL10, IL6, TNF
15	Interleukin-4 and 13 signaling⁶⁰	9.1	IL10, IL6, TNF
16	Interleukin-10 signaling⁶⁰	9.1	IL10, IL6, TNF
17	HTLV-I infection³⁴	9.0	HLA-DRB1, HLA-DRB5, IL6, TNF
18	Hematopoietic cell lineage³⁴	9.0	HLA-DRB1, HLA-DRB5, IL6, TNF
19	Innate Lymphoid Cell Differentiation Pathways⁵⁹	8.9	IFNG, IL10, TNF
20	IL-15 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types⁵⁹ Show member pathways IL-2 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types⁵⁹	8.9	IFNG, IL10, TNF
21	G-protein signaling_RhoB regulation pathway⁶⁵	8.8	CD40LG, IL10, IL6, TNF
22	IgA-Producing B Cells in the Intestine⁵⁹	8.8	CD40LG, IL10, IL6, TNF
23	Jak/STAT Signaling Pathway⁵⁹	8.8	IFNG, IL10, IL6
24	Staphylococcus aureus infection³⁴	8.7	HLA-DRB1, HLA-DRB5, IL10
25	Interferon gamma signaling⁶⁰ Show member pathways Interferon Signaling⁶⁰ Regulation of IFNG signaling⁶⁰	8.7	B2M, HLA-DRB1, HLA-DRB5, IFNG
26	Folate Metabolism⁴² Show member pathways Vitamin B12 Metabolism⁴² Selenium Micronutrient Network⁴² thioredoxin pathway⁴²	8.6	ALB, CRP, IFNG, IL6, TNF
27	Immune response IL-23 signaling pathway⁶⁵ Show member pathways Development Angiopoietin - Tie2 signaling⁶⁵ Rac1/Pak1/p38/MMP-2 pathway⁴² IL23-mediated signaling events⁴² Development PDGF signaling via STATs and NF-kB⁶⁵ Angiopoietin receptor Tie2-mediated signaling⁴² Immune response IL-10 signaling pathway⁶⁵ Angiopoietin-TIE2 Signaling⁵⁸	8.6	IFNG, IL10, IL6, TNF
28	African trypanosomiasis³⁴	8.6	IFNG, IL10, IL6, TNF
29	Amoebiasis³⁴	8.6	IFNG, IL10, IL6, TNF
30	IL27-mediated signaling events⁴² Show member pathways IL-12 Family Signaling Pathways⁵⁹ Th1 Differentiation Pathway⁵⁹	8.6	IFNG, IL10, IL6, TNF
31	Immune response IFN alpha/beta signaling pathway⁶⁵ Show member pathways Interferon alpha/beta signaling⁶⁰ Cytokine Network⁵⁸ Regulation of IFNA signaling⁶⁰	8.6	IFNG, IL10, IL6, TNF
32	Influenza A³⁴ Show member pathways Herpes simplex infection³⁴ Measles³⁴	8.5	HLA-DRB1, HLA-DRB5, IFNG, IL6, TNF
33	Rheumatoid arthritis³⁴	8.5	HLA-DRB1, HLA-DRB5, IFNG, IL6, TNF
34	T cell receptor signaling pathway³⁴ Show member pathways T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection⁴² T-Cell antigen Receptor (TCR) Signaling Pathway⁴²	8.3	CD40LG, IFNG, IL10, IL6, TNF
35	Malaria³⁴	8.3	CD40LG, IFNG, IL10, IL6, TNF
36	NF-kappaB Signaling³	8.3	B2M, CD40LG, IFNG, IL10, TNF
37	Epstein-Barr virus infection³⁴	8.2	HLA-DRB1, HLA-DRB5, IFNG, IL10
38	Cytokines and Inflammatory Response⁴²	8.2	HLA-DRB1, IFNG, IL10, IL6, TNF
39	Dendritic Cells Developmental Lineage Pathway⁵⁹	7.9	CD163, IFNG, IL10, IL6, TNF
40	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers⁵⁹	7.9	CD163, IFNG, IL10, IL6, TNF
41	Immune response NFAT in immune response⁶⁵ Show member pathways Immune response T cell receptor signaling pathway⁶⁵ Immune response CD28 signaling⁶⁵ Immune response ICOS pathway in T-helper cell⁶⁵	7.7	CD40LG, HLA-DRB1, HLA-DRB5, IFNG, IL10, TNF
42	Toxoplasmosis³⁴ Show member pathways Leishmaniasis³⁴	7.7	CD40LG, HLA-DRB1, HLA-DRB5, IFNG, IL10, TNF
43	Tuberculosis³⁴	7.6	HLA-DRB1, HLA-DRB5, IFNG, IL10, IL6, TNF
44	Th17 cell differentiation³⁴ Show member pathways Immune response IL-22 signaling pathway⁶⁵ Inflammatory bowel disease (IBD)³⁴ Th1 and Th2 cell differentiation³⁴ IL-22 Pathway⁵⁸	7.6	HLA-DRB1, HLA-DRB5, IFNG, IL10, IL6, TNF
45	Cytokine Signaling in Immune system⁶⁰ Show member pathways Signaling by Interleukins⁶⁰	7.1	B2M, CD40LG, HLA-DRB1, HLA-DRB5, IFNG, IL10
46	Allograft rejection⁴² ³⁴ Show member pathways Allograft Rejection⁴² Viral myocarditis³⁴ Asthma³⁴ CTL Mediated Apoptosis⁵⁸ Intestinal immune network for IgA production³⁴ Autoimmune thyroid disease³⁴ Type I diabetes mellitus³⁴ Graft-versus-host disease³⁴ Antigen processing and presentation³⁴ THC Differentiation Pathway⁵⁸	7.1	B2M, CD40LG, HLA-DRB1, HLA-DRB5, IFNG, IL10
47	Innate Immune System⁶⁰ Show member pathways Immune System⁶⁰ Neutrophil degranulation⁶⁰	6.4	B2M, CD40LG, CRP, HLA-DRB1, HLA-DRB5, IFNG

GO Terms for genes affiliated with Hemorrhagic Fever with Renal Syndrome

Sources:
¹⁹Gene Ontology
See all MalaCards sources

Cellular components related to Hemorrhagic Fever with Renal Syndrome according to GeneCards Suite gene sharing:

id	Name	GO ID	Score	Top Affiliating Genes
1	ER to Golgi transport vesicle membrane	GO:0012507	10.0	B2M, HLA-DRB1, HLA-DRB5
2	endocytic vesicle membrane	GO:0030666	9.7	CD163, HLA-DRB1, HLA-DRB5
3	MHC class II protein complex	GO:0042613	9.5	HLA-DRB1, HLA-DRB5
4	external side of plasma membrane	GO:0009897	8.6	B2M, CD163, CD40LG, HLA-DRB1, IFNG, IL6
5	extracellular region	GO:0005576	7.0	ALB, B2M, CD163, CD40LG, CRP, IFNG
6	extracellular space	GO:0005615	6.9	ALB, B2M, CD40LG, CRP, IFNG, IL10

Biological processes related to Hemorrhagic Fever with Renal Syndrome according to GeneCards Suite gene sharing:

(show all 41)

id	Name	GO ID	Score	Top Affiliating Genes
1	epithelial cell proliferation involved in salivary gland morphogenesis	GO:0060664	10.7	IL6, TNF
2	positive regulation of chemokine production	GO:0032722	10.6	IL6, TNF
3	regulation of immunoglobulin secretion	GO:0051023	10.6	CD40LG, TNF
4	negative regulation of alkaline phosphatase activity	GO:0010693	10.6	SEMA4D, TNF
5	positive regulation of receptor-mediated endocytosis	GO:0048260	10.5	B2M, VTN
6	positive regulation of calcidiol 1-monooxygenase activity	GO:0060559	10.4	IFNG, TNF
7	positive regulation of chemokine biosynthetic process	GO:0045080	10.4	IFNG, TNF
8	positive regulation of membrane protein ectodomain proteolysis	GO:0051044	10.4	IFNG, TNF
9	neutrophil apoptotic process	GO:0001781	10.4	IFNG, IL6
10	negative regulation of lipid storage	GO:0010888	10.3	CRP, IL6, TNF
11	positive regulation of NF-kappaB transcription factor activity	GO:0051092	10.3	CD40LG, IL6, TNF
12	positive regulation of vitamin D biosynthetic process	GO:0060557	10.3	IFNG, TNF
13	positive regulation of protein import into nucleus, translocation	GO:0033160	10.3	IFNG, IL6
14	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	GO:0002504	10.3	HLA-DRB1, HLA-DRB5
15	endothelial cell apoptotic process	GO:0072577	10.1	IL10, TNF
16	humoral immune response	GO:0006959	10.1	IFNG, IL6, TNF
17	positive regulation of peptidyl-tyrosine phosphorylation	GO:0050731	10.1	IL6, SEMA4D, VTN
18	cellular response to hepatocyte growth factor stimulus	GO:0035729	10.1	IL10, IL6
19	negative regulation of cytokine secretion involved in immune response	GO:0002740	10.1	IL10, TNF
20	positive regulation of heterotypic cell-cell adhesion	GO:0034116	10.1	IL10, TNF
21	positive regulation of nitric oxide biosynthetic process	GO:0045429	10.1	IFNG, IL6, TNF
22	defense response to Gram-positive bacterium	GO:0050830	10.1	B2M, CRP, IL6, TNF
23	positive regulation of T cell proliferation	GO:0042102	10.1	CD40LG, IFNG, IL6
24	positive regulation of vascular smooth muscle cell proliferation	GO:1904707	10.0	IL10, TNF
25	receptor biosynthetic process	GO:0032800	10.0	IL10, TNF
26	acute-phase response	GO:0006953	10.0	CD163, CRP, IL6
27	response to molecule of bacterial origin	GO:0002237	9.8	B2M, IL10
28	positive regulation of MHC class II biosynthetic process	GO:0045348	9.8	IFNG, IL10
29	positive regulation of gene expression	GO:0010628	9.8	CRP, IFNG, IL6, TNF
30	antigen processing and presentation	GO:0019882	9.8	HLA-DRB1, HLA-DRB5, IFNG
31	positive regulation of sequence-specific DNA binding transcription factor activity	GO:0051091	9.7	IL10, IL6, TNF
32	response to glucocorticoid	GO:0051384	9.6	IL10, IL6, TNF
33	defense response to protozoan	GO:0042832	9.6	IFNG, IL10, IL6
34	negative regulation of growth of symbiont in host	GO:0044130	9.6	IFNG, IL10, TNF
35	interferon-gamma-mediated signaling pathway	GO:0060333	9.4	B2M, HLA-DRB1, HLA-DRB5, IFNG
36	T cell costimulation	GO:0031295	9.3	CD40LG, HLA-DRB1, HLA-DRB5
37	response to drug	GO:0042493	9.1	B2M, IFNG, IL10, IL6
38	negative regulation of apoptotic process	GO:0043066	9.0	ALB, CD40LG, IL10, IL6, SEMA4D
39	cellular response to lipopolysaccharide	GO:0071222	9.0	B2M, IFNG, IL10, IL6, TNF
40	inflammatory response	GO:0006954	8.7	CD163, CD40LG, CRP, IL10, IL6, TNF
41	immune response	GO:0006955	7.1	B2M, CD40LG, HLA-DRB1, HLA-DRB5, IFNG, IL10