HFRS
MCID: HMR004
MIFTS: 58

Hemorrhagic Fever with Renal Syndrome (HFRS) malady

Categories: Infectious diseases, Rare diseases, Skin diseases, Nephrological diseases

Aliases & Classifications for Hemorrhagic Fever with Renal Syndrome

Aliases & Descriptions for Hemorrhagic Fever with Renal Syndrome:

Name: Hemorrhagic Fever with Renal Syndrome 12 42 14 69
Hantavirosis 56 69
Hemorrhagic Fever-Renal Syndrome 56
Hemorrhagic Nephrosonephritis 12
Hemorrhagic Fever, Russian 12
Puumala Virus Nephropathy 12
Hantavirus Fever 56
Hfrs 12

Characteristics:

Orphanet epidemiological data:

56
hemorrhagic fever-renal syndrome
Prevalence: 1-9/1000000 (Europe); Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 56  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:11266
ICD10 33 A98.5
ICD9CM 35 078.6
MeSH 42 D006480
NCIt 47 C84753
Orphanet 56 ORPHA340
MESH via Orphanet 43 C535630 D006480
UMLS via Orphanet 70 C0019101 C2930957
ICD10 via Orphanet 34 A98.5+ N08.0*
UMLS 69 C0019101

Summaries for Hemorrhagic Fever with Renal Syndrome

Disease Ontology : 12 A viral infectious disease that is a hemorrhagic fever, located in kidney, has material basis in Hantaan virus, has material basis in Dobrava-Belgrade virus, has material basis in Seoul virus, or has material basis in Puumala virus, which are carried and transmitted_by rodents. The infection has symptom headache, has symptom fever, has symptom muscle pains, has symptom facial flush, has symptom petechiae, has symptom hemorrhagic features, has symptom proteinuria, and has symptom renal failure.

MalaCards based summary : Hemorrhagic Fever with Renal Syndrome, also known as hantavirosis, is related to labyrinthitis and hepatitis, and has symptoms including headache, fever and muscle pains. An important gene associated with Hemorrhagic Fever with Renal Syndrome is CD40LG (CD40 Ligand), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Antibodies and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include kidney, t cells and testes, and related phenotypes are cardiovascular system and homeostasis/metabolism

Related Diseases for Hemorrhagic Fever with Renal Syndrome

Diseases related to Hemorrhagic Fever with Renal Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 315)
id Related Disease Score Top Affiliating Genes
1 labyrinthitis 29.6 IL10 IL6 TNF
2 hepatitis 29.1 HLA-DRB1 IFNG IL10 IL6 TNF
3 myocardial infarction 29.1 ALB CRP IL10 IL6 TNF
4 korean hemorrhagic fever 11.8
5 nephropathia epidemica 11.3
6 hantavirus pulmonary syndrome 11.3
7 hemorrhagic fever 11.0
8 pancreatitis, hereditary 10.9
9 balkan hemorrhagic fever 10.9
10 vps11-related autosomal recessive hypomyelinating leukodystrophy 10.3 IL6 TNF
11 coloboma of iris 10.3 CRP IL6
12 dyslexia 5 10.3 IL6 TNF
13 congenital dyserythropoietic anemia 10.3 ALB TNF
14 aortic atherosclerosis 10.3 IL6 TNF
15 degenerative disc disease 10.3 IL6 TNF
16 gilles de la tourette syndrome 10.3 ALB B2M
17 bile duct adenocarcinoma 10.3 ALB CD40LG
18 dextrocardia 10.2 CD40LG IL6 TNF
19 ethmoid sinus schneiderian papilloma 10.2 B2M CD40LG IL6
20 unilateral multicystic dysplastic kidney 10.2 CRP IL6 TNF
21 mineral metabolism disease 10.2 CD40LG IL6 TNF
22 joint disorders 10.2 CRP IL6 TNF
23 cicatricial lagophthalmos 10.2 CRP IL6 TNF
24 benign neonatal seizures 10.2 CRP IL6 TNF
25 glycogen storage disease viii 10.2 B2M CD40LG CRP
26 colloid adenoma 10.2 ALB CD40LG
27 tall cell variant papillary carcinoma 10.2 B2M CD40LG IL6
28 neuropathy 10.2 CRP IL6 TNF
29 autoimmune disease of central nervous system 10.2 CRP IL6 TNF
30 retinal degeneration 10.2 CD40LG CRP IL6
31 functional gastric disease 10.2 CD40LG CRP TNF
32 pancreas lymphoma 10.2 CRP IL6 TNF
33 uterine adnexa cancer 10.2 CD40LG IL6 TNF
34 blepharochalasis 10.2 CRP IL6 TNF
35 cutaneous sclerosis 10.2 CRP IL6
36 retinitis pigmentosa 51 10.2 CRP IL6 TNF
37 estrogen excess 10.2 ALB CD40LG
38 chondroma 10.2 CRP IL6 TNF
39 angiomatosis, diffuse corticomeningeal, of divry and van bogaert 10.2 HLA-DRB1 IL6 TNF
40 celiac disease 10.2 CD40LG CRP TNF
41 limb ischemia 10.2 CRP IL6 TNF
42 diabetic encephalopathy 10.2 CRP IL6 TNF
43 cranial nerve palsy 10.2 B2M CRP TNF
44 neovascular glaucoma 10.2 CRP IL6 TNF
45 pseudohypoparathyroidism 10.2 B2M CD40LG HLA-DRB1
46 bilateral parasagittal parieto-occipital polymicrogyria 10.2 HLA-DRB1 TNF
47 endobronchial leiomyoma 10.2 CD40LG CRP TNF
48 motility-related diarrhea 10.2 HLA-DRB1 IL6 TNF
49 haemonchiasis 10.2 CD40LG CRP TNF
50 angiokeratoma 10.2 ALB B2M CD40LG

Graphical network of the top 20 diseases related to Hemorrhagic Fever with Renal Syndrome:



Diseases related to Hemorrhagic Fever with Renal Syndrome

Symptoms & Phenotypes for Hemorrhagic Fever with Renal Syndrome

Symptoms:

12
  • headache
  • fever
  • muscle pains
  • facial flush
  • petechiae
  • hemorrhagic features
  • proteinuria
  • renal failure

Human phenotypes related to Hemorrhagic Fever with Renal Syndrome:

56 32 (show all 32)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 arthralgia 56 32 Frequent (79-30%) HP:0002829
2 fatigue 56 32 Very frequent (99-80%) HP:0012378
3 myalgia 56 32 Frequent (79-30%) HP:0003326
4 fever 56 32 Very frequent (99-80%) HP:0001945
5 hemoptysis 56 32 Occasional (29-5%) HP:0002105
6 photophobia 56 32 Frequent (79-30%) HP:0000613
7 abdominal pain 56 32 Frequent (79-30%) HP:0002027
8 amaurosis fugax 56 32 Occasional (29-5%) HP:0100576
9 hypertension 56 32 Occasional (29-5%) HP:0000822
10 respiratory insufficiency 56 32 Frequent (79-30%) HP:0002093
11 hypotension 56 32 Occasional (29-5%) HP:0002615
12 renal insufficiency 56 32 Frequent (79-30%) HP:0000083
13 proteinuria 56 32 Frequent (79-30%) HP:0000093
14 arrhythmia 56 32 Occasional (29-5%) HP:0011675
15 elevated hepatic transaminases 56 32 Frequent (79-30%) HP:0002910
16 thrombocytopenia 56 32 Frequent (79-30%) HP:0001873
17 tubulointerstitial abnormality 56 32 Frequent (79-30%) HP:0001969
18 migraine 56 32 Frequent (79-30%) HP:0002076
19 myopia 56 32 Occasional (29-5%) HP:0000545
20 abnormality of the myocardium 56 32 Occasional (29-5%) HP:0001637
21 gastrointestinal hemorrhage 56 32 Occasional (29-5%) HP:0002239
22 atelectasis 56 32 Frequent (79-30%) HP:0100750
23 leukocytosis 56 32 Frequent (79-30%) HP:0001974
24 conjunctivitis 56 32 Frequent (79-30%) HP:0000509
25 intracranial hemorrhage 56 32 Occasional (29-5%) HP:0002170
26 pleural effusion 56 32 Frequent (79-30%) HP:0002202
27 pulmonary infiltrates 56 32 Frequent (79-30%) HP:0002113
28 abnormality of the pericardium 56 32 Occasional (29-5%) HP:0001697
29 oliguria 56 32 Frequent (79-30%) HP:0100520
30 hypoproteinemia 56 32 Frequent (79-30%) HP:0003075
31 subconjunctival hemorrhage 56 32 Frequent (79-30%) HP:0011896
32 abnormality of the renal tubule 56 Frequent (79-30%)

MGI Mouse Phenotypes related to Hemorrhagic Fever with Renal Syndrome:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.11 CD163 CD40LG CRP IFNG IL10 IL6
2 homeostasis/metabolism MP:0005376 10.06 ALB B2M CD163 CD40LG CRP IFNG
3 hematopoietic system MP:0005397 10.02 B2M CD163 CD40LG IFNG IL10 IL6
4 endocrine/exocrine gland MP:0005379 9.95 ALB B2M CD40LG IFNG IL10 IL6
5 digestive/alimentary MP:0005381 9.91 ALB B2M IFNG IL10 IL6 TNF
6 immune system MP:0005387 9.91 IL6 SEMA4D TNF B2M CD163 CD40LG
7 liver/biliary system MP:0005370 9.63 ALB B2M IFNG IL10 IL6 TNF
8 neoplasm MP:0002006 9.43 ALB B2M IFNG IL10 IL6 TNF
9 skeleton MP:0005390 9.17 TNF CD40LG HLA-DRB5 IFNG IL10 IL6

Drugs & Therapeutics for Hemorrhagic Fever with Renal Syndrome

Drugs for Hemorrhagic Fever with Renal Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibodies Phase 3
2 Immunoglobulins Phase 3
3 Vaccines Phase 3,Phase 2,Phase 1
4
Epinephrine Approved, Vet_approved Phase 2,Phase 1 51-43-4 5816
5
Ribavirin Approved Phase 2 36791-04-5 37542
6 Epinephryl borate Phase 2,Phase 1
7 Racepinephrine Phase 2,Phase 1
8 Anti-Infective Agents Phase 2
9 Antimetabolites Phase 2
10 Antiviral Agents Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase
1 Study to Evalutate Long-term Immunity of Hantavax in High Risk Population of HFRS Completed NCT02360514 Phase 3
2 Phase 2a Immunogenicity Study of Hantaan/Puumala Virus DNA Vaccine for Prevention of Hemorrhagic Fever Active, not recruiting NCT02116205 Phase 2
3 Ribavirin for Hemorrhagic Fever With Renal Syndrome Enrolling by invitation NCT00623168 Phase 2
4 Ribavirin for Hemorrhagic Fever With Renal Syndrome in Germany Withdrawn NCT00868946 Phase 2
5 Palifermin in Preventing Oral Mucositis Caused by Chemotherapy and/or Radiation Therapy in Young Patients Undergoing Stem Cell Transplant Withdrawn NCT00728585 Phase 2
6 Study to Evaluate the Safety, Tolerability, and Immunogenicity of Hantaan and Puumala Virus DNA Vaccines Completed NCT01502345 Phase 1
7 Diagnostic of Puumala Virus Infection in France Recruiting NCT02455375
8 Cohort of Patients Infected by an Arbovirus Recruiting NCT01099852
9 Phenotyping IBS: Perceptions and Modulations of Visceral Sensations Recruiting NCT02693730

Search NIH Clinical Center for Hemorrhagic Fever with Renal Syndrome

Cochrane evidence based reviews: hemorrhagic fever with renal syndrome

Genetic Tests for Hemorrhagic Fever with Renal Syndrome

Anatomical Context for Hemorrhagic Fever with Renal Syndrome

MalaCards organs/tissues related to Hemorrhagic Fever with Renal Syndrome:

39
Kidney, T Cells, Testes, Skin, Endothelial, B Cells, Neutrophil

The Foundational Model of Anatomy Ontology organs/tissues related to Hemorrhagic Fever with Renal Syndrome:

18
Kidney

Publications for Hemorrhagic Fever with Renal Syndrome

Articles related to Hemorrhagic Fever with Renal Syndrome:

(show top 50) (show all 370)
id Title Authors Year
1
Lack of association between integrin I+vI^3 gene polymorphisms and hemorrhagic fever with renal syndrome in Han Chinese from Hubei, China. ( 28190175 )
2017
2
Prevalence of hemorrhagic fever with renal syndrome in Qingdao City, China, 2010-2014. ( 27786303 )
2016
3
Phylogeographic analysis of hemorrhagic fever with renal syndrome patients using multiplex PCR-based next generation sequencing. ( 27221218 )
2016
4
History of incomplete vaccination may associate with occurrence of hemorrhagic fever with renal syndrome with relieved clinical symptoms. ( 26636561 )
2016
5
Changes in Plasma Adiponectin Concentrations in Patients With Hemorrhagic Fever With Renal Syndrome: An Observational Prospective Study. ( 26871804 )
2016
6
Time Series Analysis of Hemorrhagic Fever with Renal Syndrome: A Case Study in Jiaonan County, China. ( 27706256 )
2016
7
Epidemiological analysis of hemorrhagic fever with renal syndrome in China with the seasonal-trend decomposition method and the exponential smoothing model. ( 27976704 )
2016
8
Prevalence of hemorrhagic fever with renal syndrome in Yiyuan County, China, 2005-2014. ( 26852019 )
2016
9
The assessment of Hantaan virus-specific antibody responses after the immunization program for hemorrhagic fever with renal syndrome in northwest China. ( 27824286 )
2016
10
Spatio-Temporal Pattern and Influencing Factors of Hemorrhagic Fever with Renal Syndrome (HFRS) in Hubei Province (China) between 2005 and 2014. ( 28030550 )
2016
11
Hemorrhagic Fever with Renal Syndrome: Pathogenesis and Clinical Picture. ( 26870699 )
2016
12
Corrigendum: Hemorrhagic Fever with Renal Syndrome: Pathogenesis and Clinical Picture. ( 27981038 )
2016
13
Genovariation Study of Hantavirus in Main Endemic Areas of Hemorrhagic Fever with Renal Syndrome in Hebei Province, China. ( 27442527 )
2016
14
Construction of a Seasonal Difference-Geographically and Temporally Weighted Regression (SD-GTWR) Model and Comparative Analysis with GWR-Based Models for Hemorrhagic Fever with Renal Syndrome (HFRS) in Hubei Province (China). ( 27801870 )
2016
15
Effects of Humidity Variation on the Hantavirus Infection and Hemorrhagic Fever with Renal Syndrome Occurrence in Subtropical China. ( 26711521 )
2016
16
Clinical characterization of two severe cases of hemorrhagic fever with renal syndrome (HFRS) caused by hantaviruses Puumala and Dobrava-Belgrade genotype Sochi. ( 27842513 )
2016
17
Molecular Diagnosis of Hemorrhagic Fever with Renal Syndrome Caused by Puumala Virus. ( 26962084 )
2016
18
Hemorrhagic Fever with Renal Syndrome, Zibo City, China, 2006-2014. ( 26812444 )
2016
19
Cytokine response to Hantaan virus infection in patients with hemorrhagic fever with renal syndrome. ( 27943332 )
2016
20
HMGB-1 as a novel predictor of disease severity and prognosis in patients with hemorrhagic fever with renal syndrome. ( 25944988 )
2015
21
Letter on the article "An hemorrhagic fever with renal syndrome revealing a leptospirosis". ( 26160283 )
2015
22
Correction: Spatiotemporal Transmission Dynamics of Hemorrhagic Fever with Renal Syndrome in China, 2005-2012. ( 25799067 )
2015
23
Changes in rodent abundance and weather conditions potentially drive hemorrhagic fever with renal syndrome outbreaks in Xi'an, China, 2005-2012. ( 25822936 )
2015
24
Puumala Hantavirus-Induced Hemorrhagic Fever with Renal Syndrome Must Be Considered across the Borders of Nephrology to Avoid Unnecessary Diagnostic Procedures. ( 26650941 )
2015
25
Modeling and predicting hemorrhagic Fever with renal syndrome trends based on meteorological factors in hu county, china. ( 25875211 )
2015
26
Comparison of Two Hybrid Models for Forecasting the Incidence of Hemorrhagic Fever with Renal Syndrome in Jiangsu Province, China. ( 26270814 )
2015
27
Acalculous cholecystitis and hemorrhagic fever with renal syndrome. ( 26139306 )
2015
28
Long-term persistence of anti-hantavirus antibodies in sera of patients undergoing hemorrhagic fever with renal syndrome and subjects vaccinated against the disease. ( 26654580 )
2015
29
Elevated serum levels of decoy receptor 3 are associated with disease severity in patients with hemorrhagic fever with renal syndrome. ( 25647584 )
2015
30
Acalculous cholecystitis and hemorrhagic fever with renal syndrome. ( 26790561 )
2015
31
Effects of Climate and Rodent Factors on Hemorrhagic Fever with Renal Syndrome in Chongqing, China, 1997-2008. ( 26193359 )
2015
32
Community Acquired Severe Acute Kidney Injury Caused by Hantavirus-Induced Hemorrhagic Fever with Renal Syndrome Has a Favorable Outcome. ( 26139246 )
2015
33
Hemorrhagic fever with renal syndrome-related encephalopathy: magnetic resonance imaging findings. ( 26362353 )
2015
34
Using autoregressive integrated moving average model to predict the incidence of hemorrhagic fever with renal syndrome in Zibo, China, 2004-2014. ( 26370428 )
2015
35
Acalculous cholecystitis associated with hemorrhagic fever with renal syndrome: a case report. ( 25982259 )
2015
36
Upregulation of IFN-I^ and IL-12 is associated with a milder form of hantavirus hemorrhagic fever with renal syndrome. ( 24942310 )
2014
37
Increased risk for lymphoma following hemorrhagic fever with renal syndrome. ( 24965350 )
2014
38
Early indicators of severity and construction of a risk model for prognosis based upon laboratory parameters in patients with hemorrhagic fever with renal syndrome. ( 24897398 )
2014
39
The epidemic characteristics and changing trend of hemorrhagic fever with renal syndrome in Hubei Province, China. ( 24658382 )
2014
40
Hemorrhagic Fever with Renal Syndrome in the New, and Hantavirus Pulmonary Syndrome in the Old World: paradi(se)gm lost or regained? ( 24440318 )
2014
41
Analysis of incidence and related factors of hemorrhagic fever with renal syndrome in Hebei Province, China. ( 25000390 )
2014
42
Spatiotemporal heterogeneity analysis of hemorrhagic fever with renal syndrome in China using geographically weighted regression models. ( 25429681 )
2014
43
Time-specific ecologic niche models forecast the risk of hemorrhagic fever with renal syndrome in Dongting Lake district, China, 2005-2010. ( 25184252 )
2014
44
Analysis of an outbreak of hemorrhagic fever with renal syndrome in college students in Xi'an, China. ( 24481251 )
2014
45
The spatial analysis on hemorrhagic fever with renal syndrome in Jiangsu province, China based on geographic information system. ( 25207806 )
2014
46
Elevated Soluble CD163 Plasma Levels Are Associated with Disease Severity in Patients with Hemorrhagic Fever with Renal Syndrome. ( 25392926 )
2014
47
Dobrava virus carried by the yellow-necked field mouse Apodemus flavicollis, causing hemorrhagic fever with renal syndrome in Romania. ( 24746107 )
2014
48
Increased Risk of Acute Myocardial Infarction and Stroke During Hemorrhagic Fever with Renal Syndrome: A Self-Controlled Case Series Study. ( 24398017 )
2014
49
Seasonal amplitude of hemorrhagic fever with renal syndrome in China: a call for attention to neglected regions. ( 24944230 )
2014
50
Spatiotemporal transmission dynamics of hemorrhagic fever with renal syndrome in China, 2005-2012. ( 25412324 )
2014

Variations for Hemorrhagic Fever with Renal Syndrome

Expression for Hemorrhagic Fever with Renal Syndrome

Search GEO for disease gene expression data for Hemorrhagic Fever with Renal Syndrome.

Pathways for Hemorrhagic Fever with Renal Syndrome

Pathways related to Hemorrhagic Fever with Renal Syndrome according to GeneCards Suite gene sharing:

(show all 47)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.95 B2M CD40LG CRP HLA-DRB1 HLA-DRB5 IFNG
2
Show member pathways
13.26 B2M CD40LG HLA-DRB1 HLA-DRB5 IFNG IL10
3
Show member pathways
12.76 HLA-DRB1 HLA-DRB5 IFNG IL6 TNF
4
Show member pathways
12.54 CD40LG HLA-DRB1 HLA-DRB5 IFNG IL10 TNF
5
Show member pathways
12.53 IFNG IL10 IL6 TNF
6
Show member pathways
12.5 B2M CD40LG HLA-DRB1 HLA-DRB5 IFNG IL10
7 12.49 B2M CD40LG IFNG IL10 TNF
8
Show member pathways
12.49 HLA-DRB1 HLA-DRB5 IFNG IL10 IL6 TNF
9
Show member pathways
12.48 B2M HLA-DRB1 HLA-DRB5 IFNG
10 12.38 HLA-DRB1 HLA-DRB5 IL6 TNF
11
Show member pathways
12.38 CD40LG IFNG IL10 IL6 TNF
12 12.27 HLA-DRB1 HLA-DRB5 IFNG IL10
13
Show member pathways
12.27 ALB CRP IFNG IL6 TNF
14
Show member pathways
12.12 IFNG IL10 IL6 TNF
15
Show member pathways
12.07 CD40LG HLA-DRB1 HLA-DRB5 IFNG IL10 TNF
16 11.99 HLA-DRB1 HLA-DRB5 IFNG IL10 IL6 TNF
17 11.96 IFNG IL6 TNF
18 11.93 IL10 IL6 TNF
19
Show member pathways
11.92 B2M HLA-DRB1 IFNG
20
Show member pathways
11.92 IFNG IL10 IL6 TNF
21 11.92 CD163 IFNG IL10 IL6 TNF
22 11.89 IFNG IL6 VTN
23 11.87 HLA-DRB1 HLA-DRB5 IL6 TNF
24 11.86 IFNG IL10 IL6 TNF
25 11.76 IFNG IL10 TNF
26 11.76 HLA-DRB1 HLA-DRB5 IFNG IL6 TNF
27
Show member pathways
11.74 CD40LG IFNG TNF
28 11.74 IL10 IL6 TNF
29 11.67 IFNG IL10 IL6
30 11.67 CD40LG IL10 IL6 TNF
31 11.65 CD163 IFNG IL10 IL6 TNF
32
Show member pathways
11.63 B2M IFNG TNF
33
Show member pathways
11.6 CD40LG IFNG IL6 TNF
34 11.59 HLA-DRB1 HLA-DRB5 IL10
35 11.53 IFNG IL6 TNF
36 11.51 IL10 IL6 TNF
37 11.49 IL6 TNF VTN
38 11.46 IFNG IL6 TNF
39
Show member pathways
11.41 IFNG IL10 TNF
40 11.34 IL10 IL6 TNF
41 11.31 CD40LG IFNG VTN
42 11.29 IFNG IL6 TNF
43 11.28 IFNG IL10 IL6 TNF
44 11.18 CD40LG IL10 IL6 TNF
45 11.04 CD40LG IFNG IL10 IL6 TNF
46 11.01 CRP IL6 TNF
47 10.5 HLA-DRB1 IFNG IL10 IL6 TNF

GO Terms for Hemorrhagic Fever with Renal Syndrome

Cellular components related to Hemorrhagic Fever with Renal Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.85 ALB B2M CD163 CD40LG CRP IFNG
2 extracellular space GO:0005615 9.65 ALB B2M CD40LG CRP IFNG IL10
3 endocytic vesicle membrane GO:0030666 9.5 CD163 HLA-DRB1 HLA-DRB5
4 ER to Golgi transport vesicle membrane GO:0012507 9.43 B2M HLA-DRB1 HLA-DRB5
5 MHC class II protein complex GO:0042613 9.37 HLA-DRB1 HLA-DRB5
6 external side of plasma membrane GO:0009897 9.17 B2M CD163 CD40LG HLA-DRB1 IFNG IL6

Biological processes related to Hemorrhagic Fever with Renal Syndrome according to GeneCards Suite gene sharing:

(show all 41)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.97 CRP IFNG IL6 TNF
2 response to drug GO:0042493 9.95 B2M IFNG IL10 IL6
3 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.86 CD40LG IL6 TNF
4 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.83 IL10 IL6 TNF
5 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.81 IL6 SEMA4D VTN
6 T cell costimulation GO:0031295 9.8 CD40LG HLA-DRB1 HLA-DRB5
7 response to glucocorticoid GO:0051384 9.79 IL10 IL6 TNF
8 positive regulation of T cell proliferation GO:0042102 9.78 CD40LG IFNG IL6
9 humoral immune response GO:0006959 9.75 IFNG IL6 TNF
10 antigen processing and presentation GO:0019882 9.74 HLA-DRB1 HLA-DRB5 IFNG
11 inflammatory response GO:0006954 9.73 CD163 CD40LG CRP IL10 IL6 TNF
12 positive regulation of nitric oxide biosynthetic process GO:0045429 9.72 IFNG IL6 TNF
13 positive regulation of receptor-mediated endocytosis GO:0048260 9.68 B2M VTN
14 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.68 IL10 TNF
15 positive regulation of chemokine production GO:0032722 9.68 IL6 TNF
16 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.67 IFNG TNF
17 cellular response to hepatocyte growth factor stimulus GO:0035729 9.67 IL10 IL6
18 defense response to Gram-positive bacterium GO:0050830 9.67 B2M CRP IL6 TNF
19 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.66 HLA-DRB1 HLA-DRB5
20 response to molecule of bacterial origin GO:0002237 9.65 B2M IL10
21 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.65 IL10 TNF
22 acute-phase response GO:0006953 9.65 CD163 CRP IL6
23 positive regulation of protein import into nucleus, translocation GO:0033160 9.64 IFNG IL6
24 positive regulation of chemokine biosynthetic process GO:0045080 9.63 IFNG TNF
25 endothelial cell apoptotic process GO:0072577 9.62 IL10 TNF
26 positive regulation of MHC class II biosynthetic process GO:0045348 9.62 IFNG IL10
27 interferon-gamma-mediated signaling pathway GO:0060333 9.62 B2M HLA-DRB1 HLA-DRB5 IFNG
28 defense response to protozoan GO:0042832 9.61 IFNG IL10 IL6
29 negative regulation of cytokine secretion involved in immune response GO:0002740 9.59 IL10 TNF
30 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.58 IL6 TNF
31 negative regulation of growth of symbiont in host GO:0044130 9.58 IFNG IL10 TNF
32 regulation of immunoglobulin secretion GO:0051023 9.56 CD40LG TNF
33 receptor biosynthetic process GO:0032800 9.54 IL10 TNF
34 neutrophil apoptotic process GO:0001781 9.52 IFNG IL6
35 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.51 IFNG TNF
36 negative regulation of alkaline phosphatase activity GO:0010693 9.49 SEMA4D TNF
37 positive regulation of vitamin D biosynthetic process GO:0060557 9.46 IFNG TNF
38 cellular response to lipopolysaccharide GO:0071222 9.35 B2M IFNG IL10 IL6 TNF
39 negative regulation of lipid storage GO:0010888 9.33 CRP IL6 TNF
40 immune response GO:0006955 9.32 B2M CD40LG HLA-DRB1 HLA-DRB5 IFNG IL10
41 negative regulation of apoptotic process GO:0043066 10 ALB CD40LG IL10 IL6 SEMA4D

Molecular functions related to Hemorrhagic Fever with Renal Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 CD40LG IFNG IL10 IL6 TNF

Sources for Hemorrhagic Fever with Renal Syndrome

3 CDC
7 CNVD
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10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
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48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
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70 UMLS via Orphanet
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