MCID: HMR004
MIFTS: 57

Hemorrhagic Fever with Renal Syndrome malady

Categories: Infectious diseases, Rare diseases, Skin diseases, Nephrological diseases

Aliases & Classifications for Hemorrhagic Fever with Renal Syndrome

About this section
Sources:
11Disease Ontology, 13DISEASES, 29ICD10, 30ICD10 via Orphanet, 31ICD9CM, 38MeSH, 39MESH via Orphanet, 44NCIt, 53Orphanet, 61SNOMED-CT, 67UMLS, 68UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Hemorrhagic Fever with Renal Syndrome:

Name: Hemorrhagic Fever with Renal Syndrome 11 38 13 67
Hantavirosis 53 67
Hemorrhagic Fever-Renal Syndrome 53
Hemorrhagic Nephrosonephritis 11
 
Hemorrhagic Fever, Russian 11
Puumala Virus Nephropathy 11
Hantavirus Fever 53
Hfrs 11

Characteristics:

Orphanet epidemiological data:

53
hantavirosis:
Prevalence: 1-9/1000000 (Europe); Age of onset: All ages; Age of death: any age

Classifications:



External Ids:

Disease Ontology11 DOID:11266
ICD1029 A98.5
ICD9CM31 078.6
MeSH38 D006480
NCIt44 C84753
Orphanet53 ORPHA340
MESH via Orphanet39 C535630, D006480
UMLS via Orphanet68 C0019101, C2930957
ICD10 via Orphanet30 A98.5+, N08.0*

Summaries for Hemorrhagic Fever with Renal Syndrome

About this section
Disease Ontology:11 A viral infectious disease that is a hemorrhagic fever, located in kidney, has material basis in Hantaan virus, has material basis in Dobrava-Belgrade virus, has material basis in Seoul virus, or has material basis in Puumala virus, which are carried and transmitted by rodents. The infection has symptom headache, has symptom fever, has symptom muscle pains, has symptom facial flush, has symptom petechiae, has symptom hemorrhagic features, has symptom proteinuria, and has symptom renal failure.

MalaCards based summary: Hemorrhagic Fever with Renal Syndrome, also known as hantavirosis, is related to balkan hemorrhagic fever and scrub typhus, and has symptoms including abnormality of temperature regulation, renal insufficiency and abnormality of the renal tubule. An important gene associated with Hemorrhagic Fever with Renal Syndrome is CD40LG (CD40 Ligand), and among its related pathways are amb2 Integrin signaling and Pertussis. Affiliated tissues include kidney, kidney and t cells, and related mouse phenotypes are digestive/alimentary and liver/biliary system.

Related Diseases for Hemorrhagic Fever with Renal Syndrome

About this section

Diseases related to Hemorrhagic Fever with Renal Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 370)
idRelated DiseaseScoreTop Affiliating Genes
1balkan hemorrhagic fever32.1CD40LG, IL10
2scrub typhus30.4ALB, TNF
3hepatitis b29.4IFNG, IL10, TNF
4myocardial infarction28.9ALB, CRP, IL10, IL6, TNF
5hemophagocytic lymphohistiocytosis28.7HLA-DRB1, IFNG, IL10, IL6, TNF
6korean hemorrhagic fever11.8
7nephropathia epidemica11.3
8hantavirus pulmonary syndrome11.3
9hemorrhagic fever11.0
10pancreatitis, hereditary10.9
11aortic arch interruption10.7IL6, TNF
12cutaneous leishmaniasis10.6IL6, TNF
13aneurysm of sinus of valsalva10.6CRP, IL6
14maligant granulosa cell tumor of ovary10.6IL6, TNF
15solitary osseous plasmacytoma10.6B2M, IL6
16carbon baby syndrome10.6CRP, IL6
17hemometra10.6IL6, TNF
18monoclonal paraproteinemia10.6CD40LG, IL6
19tricho odonto onycho dermal syndrome10.6IL6, TNF
20scrotum paget's disease10.6IL6, TNF
21bone cancer10.6CD40LG, CRP
22dehydration polycythemia10.6CD40LG, CRP
23night blindness10.6CD40LG, TNF
24common variable immunodeficiency10.5HLA-DRB1, TNF
25calcinosis10.5CD40LG, CRP
26cataract 2510.5ALB, B2M
27parsonage turner syndrome10.5HLA-DRB1, TNF
28weber syndrome10.5HLA-DRB1, TNF
29angioma hereditary neurocutaneous10.5CRP, IL6
30brucella abortus brucellosis10.5CD40LG, TNF
31fallopian tube leiomyosarcoma10.5CD40LG, CRP
32myopathy-growth delay-intellectual disability-hypospadias syndrome10.5HLA-DRB1, TNF
33disease_ontology10.5CD40LG, IL6
34midline interhemispheric variant of holoprosencephaly10.5CRP, IL6
35krieble bixler syndrome10.5HLA-DRB1, TNF
36piepkorn karp hickok syndrome10.5IL10, TNF
37postencephalitic parkinson disease10.5ALB, CD40LG
38vesicoureteral reflux10.5ALB, B2M
396q terminal deletion syndrome10.5IL10, TNF
40non-secretory myeloma10.5CD40LG, IL6, TNF
41heart lymphoma10.5B2M, CD40LG, IL6
42lipid-rich breast carcinoma10.5B2M, CD40LG, IL6
43foodborne botulism10.5CD40LG, IL6, TNF
44marek disease10.5ALB, CD40LG
45islet cell tumor10.5CRP, IL6, TNF
46small intestinal vasoactive intestinal peptide producing tumor10.5CD40LG, CRP
47neurotic disorder10.5B2M, CD40LG, IL6
48paraneoplastic polyneuropathy10.4CRP, IL6, TNF
49mechanical lagophthalmos10.4CRP, IL6, TNF
50oral candidiasis10.4CRP, IL6, TNF

Graphical network of the top 20 diseases related to Hemorrhagic Fever with Renal Syndrome:



Diseases related to hemorrhagic fever with renal syndrome

Symptoms for Hemorrhagic Fever with Renal Syndrome

About this section

Symptoms:

 11 (show all 8)
  • headache
  • fever
  • muscle pains
  • facial flush
  • petechiae
  • hemorrhagic features
  • proteinuria
  • renal failure

Human phenotypes related to Hemorrhagic Fever with Renal Syndrome:

 63 53 (show all 34)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 abnormality of temperature regulation63 hallmark (90%) HP:0004370
2 renal insufficiency63 53 typical (50%) Frequent (79-30%) HP:0000083
3 abnormality of the renal tubule63 53 typical (50%) Frequent (79-30%) HP:0000091
4 proteinuria63 53 typical (50%) Frequent (79-30%) HP:0000093
5 conjunctivitis63 53 typical (50%) Frequent (79-30%) HP:0000509
6 photophobia63 53 typical (50%) Frequent (79-30%) HP:0000613
7 thrombocytopenia63 53 typical (50%) Frequent (79-30%) HP:0001873
8 leukocytosis63 53 typical (50%) Frequent (79-30%) HP:0001974
9 abdominal pain63 53 typical (50%) Frequent (79-30%) HP:0002027
10 migraine63 53 typical (50%) Frequent (79-30%) HP:0002076
11 respiratory insufficiency63 53 typical (50%) Frequent (79-30%) HP:0002093
12 abnormality of the pleura63 typical (50%) HP:0002103
13 pulmonary infiltrates63 53 typical (50%) Frequent (79-30%) HP:0002113
14 arthralgia63 53 typical (50%) Frequent (79-30%) HP:0002829
15 elevated hepatic transaminases63 53 typical (50%) Frequent (79-30%) HP:0002910
16 hypoproteinemia63 53 typical (50%) Frequent (79-30%) HP:0003075
17 myalgia63 53 typical (50%) Frequent (79-30%) HP:0003326
18 atelectasis63 53 typical (50%) Frequent (79-30%) HP:0100750
19 myopia63 53 occasional (7.5%) Occasional (29-5%) HP:0000545
20 hypertension63 53 occasional (7.5%) Occasional (29-5%) HP:0000822
21 abnormality of the myocardium63 53 occasional (7.5%) Occasional (29-5%) HP:0001637
22 abnormality of the pericardium63 53 occasional (7.5%) Occasional (29-5%) HP:0001697
23 hemoptysis63 53 occasional (7.5%) Occasional (29-5%) HP:0002105
24 intracranial hemorrhage63 53 occasional (7.5%) Occasional (29-5%) HP:0002170
25 gastrointestinal hemorrhage63 53 occasional (7.5%) Occasional (29-5%) HP:0002239
26 hypotension63 53 occasional (7.5%) Occasional (29-5%) HP:0002615
27 arrhythmia63 53 occasional (7.5%) Occasional (29-5%) HP:0011675
28 amaurosis fugax63 53 occasional (7.5%) Occasional (29-5%) HP:0100576
29 fever53 Very frequent (99-80%)
30 tubulointerstitial abnormality53 Frequent (79-30%)
31 pleural effusion53 Frequent (79-30%)
32 subconjunctival hemorrhage53 Frequent (79-30%)
33 fatigue53 Very frequent (99-80%)
34 oliguria53 Frequent (79-30%)

Drugs & Therapeutics for Hemorrhagic Fever with Renal Syndrome

About this section

Drugs for Hemorrhagic Fever with Renal Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1AntibodiesPhase 36045
2VaccinesPhase 3, Phase 2, Phase 16428
3ImmunoglobulinsPhase 36045
4
Epinephrineapproved, vet_approvedPhase 2, Phase 193351-43-45816
Synonyms:
(-)-(R)-Epinephrine
(-)-3,4-Dihydroxy-a-[2-(methylamino)ethyl]benzyl alcohol
(-)-3,4-Dihydroxy-alpha-((methylamino)methyl)benzyl alcohol
(-)-3,4-Dihydroxy-alpha-[2-(methylamino)ethyl]benzyl alcohol
(-)-3,4-dihydroxy-a-[(methylamino)methyl]-Benzyl alcohol
(-)-3,4-dihydroxy-alpha-[(methylamino)methyl]-Benzyl alcohol
(-)-Adrenalin
(-)-Adrenaline
(-)-Epinephrine
(-)-R-Epinephrine
(R)-(-)-Adnephrine
(R)-(-)-Adrenaline
(R)-(-)-Epinephrine
(R)-(-)-Epirenamine
(R)-(−)-adrenaline
(R)-4-[1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
(R)-4-[1-hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol
(R)-Adrenaline
(R)-Epinephrine
(−)-adrenaline
02252_FLUKA
1-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
1-Adrenalin
1-Epinephrine
4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-benzenediol
4-(1-hydroxy-2-methylamino-ethyl)benzene-1,2-diol
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol
51-43-4
51-43-4 (FREE BASE)
51028-73-0
A0173
AC-13188
AC1L1L7B
ADR ADRENALINE
ADROP
AI3-19015
Adnephrine
Adrenal
Adrenalin
Adrenalin (TN)
Adrenalin in Oil
Adrenalin-Medihaler
Adrenalina
Adrenalina [DCIT]
Adrenaline
Adrenaline (JP15)
Adrenaline/Epinephrine
Adrenalinum
Adrenamine
Adrenan
Adrenapax
Adrenasol
Adrenatrate
Adrenine
Adrenodis
Adrenohorma
Adrenosan
Adrenutol
Adrin
Adrine
Ana-Guard
Ana-Kit
Antiasthmatique
Asmatane Mist
Asthma meter mist
Asthma-nefrin
Asthmahaler Mist
Asthmanefrin
Astmahalin
Astminhal
BIDD:GT0119
Balmadren
Bernarenin
Biorenine
Bosmin
Brevirenin
Bronkaid
Bronkaid Mist
Bronkaid Suspension Mist
Bupivacaine Hcl and Epinephrine
C00788
CCRIS 4812
CHEBI:28918
CHEMBL679
CID5816
Chelafrin
Citanest Forte
Corisol
D-Epifrin
D-Epinephrine
D00095
DB00668
Drenamist
Dylephrin
Dyspne-Inhal
E4250_SIGMA
EINECS 200-098-7
EPI E Z PEN JR
EPIPEN E Z PEN
EPIPEN JR
Epi EZ Pen Jr
Epifrin
Epiglaufrin
Epinefrin
Epinefrin [Czech]
Epinefrina
Epinefrina [INN-Spanish]
Epinephran
Epinephrin
Epinephrine
Epinephrine (USP)
Epinephrine (USP/INN)
Epinephrine [USAN:INN:JAN]
Epinephrine hydrochloride
Epinephrinum
Epinephrinum [INN-Latin]
Epipen
Epipen (TN)
Epipen Auto-Injector
Epipen EZ Pen
Epipen Jr.
Epipen Jr. Auto-Injector
Epirenamine
Epirenan
Epirenin
Epitrate
Eppy
Esphygmogenina
Exadrin
 
Glaucon
Glaucosan
Glauposine
Glycirenan
HSCI1_000215
HSDB 4289
Haemostasin
Haemostatin
Hektalin
Hemisine
Hemostasin
Hemostatin
Hypernephrin
Hyporenin
IOP
Intranefrin
Iontocaine
Isoptoepinal
Kidoline
L-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
L-Adrenaline
L-Adrenaline Base
L-Epinehphrine
L-Epinephrine
L-Epirenamine
L-Methylaminoethanolcatechol
L-epinephrine
LS-156
Levo-Methylaminoethanolcatechol
Levoadrenaline
Levoepinephrine
Levorenen
Levorenin
Levorenine
Levoreninum
Lopac-E-4642
Lyodrin
Lyophrin
Medihaler-Epi
Metanephrin
Methylaminoethanolcatechol
Methylarterenol
Micronefrin
Micronephrine
MolPort-002-051-368
Mucidrina
Myosthenine
Mytrate
NCGC00015417-01
NCGC00142615-01
NCGC00142615-03
NCGC00142615-04
NCGC00142615-05
NCGC00142615-06
NCGC00142615-07
NSC 62786
NSC62786
Nephridine
Nieraline
PDSP1_001120
PDSP2_001104
Paranephrin
Primatene
Primatene Mist
R-(-)-Epinephrine
R-Adrenaline
RCRA waste no. P042
Racemic Epinephrine
Racepinephrine
Rcra waste number P042
Renagladin
Renaglandin
Renaglandulin
Renaleptine
Renalina
Renoform
Renostypricin
Renostypticin
Renostyptin
SMP1_000227
ST069368
SUS-PHRINE SULFITE-FREE
Scurenaline
Septocaine
Simplene
Sindrenina
Soladren
Sphygmogenin
Stryptirenal
Styptirenal
Supracapsulin
Supradin
Supranefran
Supranephrane
Supranephrine
Supranol
Suprarenaline
Suprarenin
Suprel
Surenine
Surrenine
Sus-Phrine
Sus-phrine
Susphrine
Sympathin I
Takamina
Takamine
Tokamina
Tonogen
Twinject
Twinject 0.15
Twinject 0.3
Twinject 0.30
UNII-YKH834O4BH
Vaponefrin
Vasoconstrictine
Vasoconstrictor
Vasodrine
Vasoton
Vasotonin
adrenaline
bmse000316
d-Adrenaline
epinephrine
l-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
l-Adrenalin
l-Adrenaline
l-Epinephine
l-Epinephrine (synthetic)
l-Epirenamine
l-Methylaminoethanolcatechol
levoepinephrine
nchembio747-comp9
5
RibavirinapprovedPhase 298436791-04-537542
Synonyms:
1-.beta.-D-Ribofuranosyl-1,2,4-triazolo-3-carboxamide
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazole-3-carboxamide
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-1,2,4-triazole-3-carboxamide
1-beta-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide
1-beta-D-Ribofuranosyl-1H-1,2,4-triazole-3-carboxamide
1-beta-D-ribofuranosyl-1-H-1,2,4-triazole-3-carboxamide
36791-04-5
437710-49-1
66510-90-5
AA-504/07617051
AB00430481
AC1L1XXZ
AC1Q1IDC
AC1Q4ZGS
AKOS001715163
BB_NC-0567
BPBio1_001195
BRN 0892462
BSPBio_001085
BSPBio_003352
C-Virin
CHEMBL1643
CID37542
Copegus
Copegus (TN)
Cotronak
D00423
DB00811
DRG-0028
DivK1c_000782
Drug: Ribavirin
EU-0101063
FT-0082885
HMS2090L15
HMS2094O09
HMS502H04
HSDB 6513
ICN-1229
IDI1_000782
KBio1_000782
KBio2_002328
KBio2_004896
KBio2_007464
KBio3_002854
KBioGR_001804
KBioSS_002331
KS-1104
LS-1241
Lopac0_001063
MLS000028486
MLS002222317
MolPort-002-507-104
MolPort-002-885-856
NCGC00090726-01
NCGC00090726-03
NCGC00090726-04
NCGC00090726-05
NCGC00090726-06
NCGC00090726-07
NINDS_000782
NSC 163039
 
NSC163039
Prestwick3_000993
R 9644
R-964
R9644_SIGMA
RBV
RG-964
RIBAV
RTC
RTCA
RTP
Ravanex
Rebetol
Rebetol (TN)
Rebetron
Rebretron
Ribacine
Ribamide
Ribamidil
Ribamidyl
Ribasphere
Ribasphere (TN)
Ribav
Ribavirin
Ribavirin (JAN/USP/INN)
Ribavirin Capsules
Ribavirin Triphosphate
Ribavirin [USAN:INN]
Ribavirin-TP
Ribavirina
Ribavirina [INN-Spanish]
Ribavirine
Ribavirine [INN-French]
Ribavirinum
Ribavirinum [INN-Latin]
Ribovirin
Ro 20-9963/000
Ro-20-9963
S2504_Selleck
SCH 18908
SMP1_000261
SMR000058315
SPECTRUM1503938
SR-01000076112-3
Spectrum3_001876
Spectrum4_001252
Spectrum5_002075
Spectrum_001826
Tribavirin
UNII-49717AWG6K
Varazid
Vilona
Viramid
Viramide
Virazid
Virazide
Virazole
Virazole (Ribavirin) Inhalation Solution
Virazole (TN)
Virazole 5'-triphosphate
ZINC01035331
ribavirin
6Epinephryl boratePhase 2, Phase 1933
7RacepinephrinePhase 2, Phase 1933
8Antiviral AgentsPhase 29732
9AntimetabolitesPhase 211774
10Anti-Infective AgentsPhase 221402

Interventional clinical trials:

idNameStatusNCT IDPhase
1Study to Evalutate Long-term Immunity of Hantavax in High Risk Population of HFRSCompletedNCT02360514Phase 3
2Phase 2a Immunogenicity Study of Hantaan/Puumala Virus DNA Vaccine for Prevention of Hemorrhagic FeverRecruitingNCT02116205Phase 2
3Ribavirin for Hemorrhagic Fever With Renal SyndromeEnrolling by invitationNCT00623168Phase 2
4Ribavirin for Hemorrhagic Fever With Renal Syndrome in GermanyWithdrawnNCT00868946Phase 2
5Palifermin in Preventing Oral Mucositis Caused by Chemotherapy and/or Radiation Therapy in Young Patients Undergoing Stem Cell TransplantWithdrawnNCT00728585Phase 2
6Study to Evaluate the Safety, Tolerability, and Immunogenicity of Hantaan and Puumala Virus DNA VaccinesCompletedNCT01502345Phase 1
7Diagnostic of Puumala Virus Infection in FranceRecruitingNCT02455375
8Cohort of Patients Infected by an ArbovirusRecruitingNCT01099852
9Phenotyping IBS: Perceptions and Modulations of Visceral SensationsRecruitingNCT02693730

Search NIH Clinical Center for Hemorrhagic Fever with Renal Syndrome


Cochrane evidence based reviews: hemorrhagic fever with renal syndrome

Genetic Tests for Hemorrhagic Fever with Renal Syndrome

About this section

Anatomical Context for Hemorrhagic Fever with Renal Syndrome

About this section

MalaCards organs/tissues related to Hemorrhagic Fever with Renal Syndrome:

35
Kidney, T cells, Testes, Skin, B cells, Endothelial, Neutrophil

FMA organs/tissues related to Hemorrhagic Fever with Renal Syndrome:

17
Kidney

Animal Models for Hemorrhagic Fever with Renal Syndrome or affiliated genes

About this section

MGI Mouse Phenotypes related to Hemorrhagic Fever with Renal Syndrome:

40
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.9ALB, B2M, IFNG, IL10, IL6, TNF
2MP:00053708.8ALB, B2M, IFNG, IL10, IL6, TNF
3MP:00020068.7ALB, B2M, IFNG, IL10, IL6, TNF
4MP:00053798.6ALB, B2M, CD40LG, IFNG, IL10, IL6
5MP:00053858.4B2M, CD40LG, CRP, IFNG, IL10, IL6
6MP:00053878.3B2M, CD40LG, CRP, IFNG, IL10, IL6
7MP:00053978.3B2M, CD40LG, IFNG, IL10, IL6, SEMA4D
8MP:00053907.7CD40LG, HLA-DRB5, IFNG, IL10, IL6, SEMA4D
9MP:00053767.5ALB, B2M, CD40LG, CRP, IFNG, IL10

Publications for Hemorrhagic Fever with Renal Syndrome

About this section

Articles related to Hemorrhagic Fever with Renal Syndrome:

(show top 50)    (show all 370)
idTitleAuthorsYear
1
History of incomplete vaccination may associate with occurrence of hemorrhagic fever with renal syndrome with relieved clinical symptoms. (26636561)
2016
2
Construction of a Seasonal Difference-Geographically and Temporally Weighted Regression (SD-GTWR) Model and Comparative Analysis with GWR-Based Models for Hemorrhagic Fever with Renal Syndrome (HFRS) in Hubei Province (China). (27801870)
2016
3
Acalculous cholecystitis associated with hemorrhagic fever with renal syndrome: a case report. (25982259)
2015
4
Using autoregressive integrated moving average model to predict the incidence of hemorrhagic fever with renal syndrome in Zibo, China, 2004-2014. (26370428)
2015
5
Comparison of Two Hybrid Models for Forecasting the Incidence of Hemorrhagic Fever with Renal Syndrome in Jiangsu Province, China. (26270814)
2015
6
Increased risk for lymphoma following hemorrhagic fever with renal syndrome. (24965350)
2014
7
Analysis of an outbreak of hemorrhagic fever with renal syndrome in college students in Xi'an, China. (24481251)
2014
8
Increasing incidence of hemorrhagic fever with renal syndrome could be associated with livestock husbandry in Changchun, northeastern China. (24894341)
2014
9
Hemorrhagic fever with renal syndrome and Crimean-Congo hemorrhagic fever as causes of acute undifferentiated febrile illness in Bulgaria. (23421884)
2013
10
A case of ruptured renal cortical arteriovenous malformation of the right testicular vein in hemorrhagic fever with renal syndrome. (23682233)
2013
11
Serum TNF-I+, sTNFR1, IL-6, IL-8 and IL-10 levels in hemorrhagic fever with renal syndrome. (23603136)
2013
12
Correction: Investigating the Effects of Food Available and Climatic Variables on the Animal Host Density of Hemorrhagic Fever with Renal Syndrome in Changsha, China. (24058426)
2013
13
Hantaan virus RNA load in patients having hemorrhagic fever with renal syndrome: correlation with disease severity. (22869912)
2013
14
Investigating the effects of food available and climatic variables on the animal host density of hemorrhagic Fever with renal syndrome in changsha, china. (23637849)
2013
15
Isolation and characterization of hantaviruses in Far East Russia and etiology of hemorrhagic fever with renal syndrome in the region. (22403334)
2012
16
Increased serum fibronectin levels in patients with hemorrhagic fever with renal syndrome. (19701604)
2010
17
Collective immunity of the population from endemic zones of hemorrhagic fever with renal syndrome in Kosovo. (20088164)
2009
18
Hemorrhagic fever with renal syndrome in 4 US soldiers, South Korea, 2005. (19891878)
2009
19
Hemorrhagic fever with renal syndrome caused by 2 lineages of Dobrava hantavirus, Russia. (18394280)
2008
20
Hemorrhagic fever with renal syndrome complicated with pregnancy: a case report. (16913449)
2006
21
Hemorrhagic fever with renal syndrome in the Pomurje region of Slovenia--an 18-year survey. (16053195)
2005
22
Rehabilitation therapy of convalescents after hemorrhagic fever with renal syndrome in outpatient clinic]. (15108430)
2004
23
Hemorrhagic fever with renal syndrome. (15540521)
2004
24
Serological analysis of hemorrhagic fever with renal syndrome (HFRS) patients in Far Eastern Russia and identification of the causative hantavirus genotype. (12898330)
2003
25
A case of torsade de pointes associated with hypopituitarism due to hemorrhagic fever with renal syndrome. (11410700)
2001
26
Epidemiological progresses of hemorrhagic fever with renal syndrome in China. (11593522)
1999
27
Puumala and Dobrava viruses cause hemorrhagic fever with renal syndrome in Bosnia-Herzegovina: evidence of highly cross-neutralizing antibody responses in early patient sera. (9298732)
1997
28
Pathogenetic and clinical aspects of the renal involvement in hemorrhagic fever with renal syndrome. (9044447)
1997
29
Direct genetic detection of Dobrava virus in Greek and Albanian patients with hemorrhagic fever with renal syndrome. (8699076)
1996
30
Hemorrhagic fever with renal syndrome: a study of sequelae following nephropathia epidemica. (7944947)
1994
31
Epidemiologic surveillance on the hemorrhagic fever with renal syndrome in China. (7908258)
1993
32
Hypertension after hemorrhagic fever with renal syndrome. (1356239)
1992
33
Comparison of European isolates of viruses causing hemorrhagic fever with renal syndrome by a neutralization test. (1684888)
1991
34
Localization and changes of hemorrhagic fever with renal syndrome virus in lymphocyte subpopulation. (1680612)
1991
35
Interruption study of viremia of patients with hemorrhagic fever with renal syndrome in the febrile phase. (1678691)
1991
36
Nephropathia epidemica: mild variant of hemorrhagic fever with renal syndrome. (1685202)
1991
37
Two cases of hyperimmunoglobulinemia E in patients with hemorrhagic fever with renal syndrome. (1679249)
1991
38
Hemorrhagic fever with renal syndrome. (2647265)
1989
39
What is new and where are the problems in research on hemorrhagic fever with renal syndrome? (2573193)
1989
40
Hemorrhagic fever with renal syndrome. (2573914)
1989
41
Cats--source of protection or infection? A case-control study of hemorrhagic fever with renal syndrome. (2889355)
1987
42
Hemorrhagic fever with renal syndrome: treatment with recombinant alpha interferon. (2881968)
1987
43
Isolation of a hantavirus from a severely ill patient with hemorrhagic fever with renal syndrome in Greece. (2890690)
1987
44
Characterization of glycoproteins of viruses causing hemorrhagic fever with renal syndrome (HFRS) using monoclonal antibodies. (2422813)
1986
45
A preliminary report on hemorrhagic fever with renal syndrome in China. (6137329)
1983
46
Hemorrhagic fever with renal syndrome (HFRS). (6134332)
1982
47
Hemorrhagic fever with renal syndrome in Finland: ecology and virology of nephropathia epidemica. (6134333)
1982
48
Hantaan virus is related to hemorrhagic fever with renal syndrome in Norway. (6125745)
1982
49
Seroepidemiologic study of epidemic hemorrhagic fever with renal syndrome in China. (6114815)
1981
50
GEOGRAPHICAL DISTRIBUTION OF HEMORRHAGIC FEVER WITH RENAL SYNDROME. (14196952)
1964

Variations for Hemorrhagic Fever with Renal Syndrome

About this section

Expression for genes affiliated with Hemorrhagic Fever with Renal Syndrome

About this section
Search GEO for disease gene expression data for Hemorrhagic Fever with Renal Syndrome.

Pathways for genes affiliated with Hemorrhagic Fever with Renal Syndrome

About this section

Pathways related to Hemorrhagic Fever with Renal Syndrome according to GeneCards Suite gene sharing:

(show all 40)
idSuper pathwaysScoreTop Affiliating Genes
19.6IL6, TNF, VTN
29.4IL10, IL6, TNF
39.4IL10, IL6, TNF
4
Show member pathways
9.3CD40LG, IFNG, TNF
59.3IFNG, IL6, TNF
69.3IFNG, IL6, TNF
79.3IFNG, IL6, TNF
8
Show member pathways
9.3B2M, IFNG, TNF
99.2CD40LG, IFNG, VTN
109.2IFNG, IL6, VTN
119.1CD40LG, IL10, IL6, TNF
129.1CD40LG, IL10, IL6, TNF
13
Show member pathways
9.1B2M, HLA-DRB1, IFNG
14
Show member pathways
9.1B2M, CD40LG, HLA-DRB5, TNF
159.1IFNG, IL10, TNF
16
Show member pathways
9.1IFNG, IL10, TNF
179.0IFNG, IL10, IL6
189.0HLA-DRB1, HLA-DRB5, IL10
199.0HLA-DRB1, HLA-DRB5, IL6, TNF
209.0HLA-DRB1, HLA-DRB5, IL6, TNF
218.8IFNG, IL10, IL6, TNF
228.8IFNG, IL10, IL6, TNF
23
Show member pathways
8.8IFNG, IL10, IL6, TNF
24
Show member pathways
8.8IFNG, IL10, IL6, TNF
25
Show member pathways
8.8IFNG, IL10, IL6, TNF
26
Show member pathways
8.6B2M, HLA-DRB1, HLA-DRB5, IFNG
278.5CD40LG, IFNG, IL10, IL6, TNF
28
Show member pathways
8.5CD40LG, IFNG, IL10, IL6, TNF
298.5B2M, CD40LG, IFNG, IL10, TNF
308.4HLA-DRB1, HLA-DRB5, IFNG, IL10
318.4HLA-DRB1, HLA-DRB5, IFNG, IL6, TNF
32
Show member pathways
8.4HLA-DRB1, HLA-DRB5, IFNG, IL6, TNF
338.4HLA-DRB1, IFNG, IL10, IL6, TNF
348.0CD163, IFNG, IL10, IL6, TNF
358.0CD163, IFNG, IL10, IL6, TNF
36
Show member pathways
7.9CD40LG, HLA-DRB1, HLA-DRB5, IFNG, IL10, TNF
37
Show member pathways
7.9CD40LG, HLA-DRB1, HLA-DRB5, IFNG, IL10, TNF
387.8HLA-DRB1, HLA-DRB5, IFNG, IL10, IL6, TNF
39
Show member pathways
7.3B2M, CD40LG, HLA-DRB1, HLA-DRB5, IFNG, IL10
40
Show member pathways
7.1B2M, CD40LG, CRP, HLA-DRB1, HLA-DRB5, IFNG

GO Terms for genes affiliated with Hemorrhagic Fever with Renal Syndrome

About this section

Cellular components related to Hemorrhagic Fever with Renal Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:004261310.2HLA-DRB1, HLA-DRB5
2ER to Golgi transport vesicle membraneGO:00125079.9B2M, HLA-DRB1, HLA-DRB5
3endocytic vesicle membraneGO:00306669.0CD163, HLA-DRB1, HLA-DRB5
4external side of plasma membraneGO:00098978.8B2M, CD40LG, IFNG, IL6, TNF
5extracellular regionGO:00055766.7ALB, B2M, CD163, CRP, IFNG, IL6
6extracellular spaceGO:00056156.7ALB, B2M, CD40LG, CRP, IFNG, IL10

Biological processes related to Hemorrhagic Fever with Renal Syndrome according to GeneCards Suite gene sharing:

(show all 34)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of chemokine productionGO:003272210.6IL6, TNF
2epithelial cell proliferation involved in salivary gland morphogenesisGO:006066410.6IL6, TNF
3regulation of immunoglobulin secretionGO:005102310.6CD40LG, TNF
4negative regulation of alkaline phosphatase activityGO:001069310.5SEMA4D, TNF
5positive regulation of receptor-mediated endocytosisGO:004826010.4B2M, VTN
6receptor biosynthetic processGO:003280010.4IL10, TNF
7negative regulation of cytokine secretion involved in immune responseGO:000274010.4IL10, TNF
8neutrophil apoptotic processGO:000178110.3IFNG, IL6
9positive regulation of vitamin D biosynthetic processGO:006055710.3IFNG, TNF
10positive regulation of calcidiol 1-monooxygenase activityGO:006055910.3IFNG, TNF
11positive regulation of membrane protein ectodomain proteolysisGO:005104410.3IFNG, TNF
12positive regulation of chemokine biosynthetic processGO:004508010.2IFNG, TNF
13cellular response to hepatocyte growth factor stimulusGO:003572910.2IL10, IL6
14negative regulation of lipid storageGO:001088810.1CRP, IL6, TNF
15response to molecule of bacterial originGO:000223710.1B2M, IL10
16response to glucocorticoidGO:00513849.9IL10, IL6, TNF
17positive regulation of MHC class II biosynthetic processGO:00453489.9IFNG, IL10
18humoral immune responseGO:00069599.9IFNG, IL6, TNF
19positive regulation of peptidyl-tyrosine phosphorylationGO:00507319.9IL6, SEMA4D, VTN
20positive regulation of sequence-specific DNA binding transcription factor activityGO:00510919.8IL10, IL6, TNF
21positive regulation of T cell proliferationGO:00421029.7CD40LG, IFNG, IL6
22defense response to protozoanGO:00428329.6IFNG, IL10, IL6
23acute-phase responseGO:00069539.6CD163, CRP, IL6
24positive regulation of nitric oxide biosynthetic processGO:00454299.6IFNG, IL6, TNF
25response to organic substanceGO:00100339.6ALB, IL10, TNF
26negative regulation of growth of symbiont in hostGO:00441309.5IFNG, IL10, TNF
27T cell costimulationGO:00312959.4CD40LG, HLA-DRB1, HLA-DRB5
28defense response to Gram-positive bacteriumGO:00508309.3B2M, CRP, IL6, TNF
29inflammatory responseGO:00069549.2CD40LG, CRP, IL10, IL6, TNF
30interferon-gamma-mediated signaling pathwayGO:00603339.2B2M, HLA-DRB1, HLA-DRB5, IFNG
31positive regulation of gene expressionGO:00106289.1CRP, IFNG, IL6, TNF
32cellular response to lipopolysaccharideGO:00712228.9B2M, IFNG, IL10, IL6, TNF
33negative regulation of apoptotic processGO:00430668.9ALB, CD40LG, IL10, IL6, SEMA4D
34response to drugGO:00424938.7B2M, IFNG, IL10, IL6

Molecular functions related to Hemorrhagic Fever with Renal Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051258.5CD40LG, IFNG, IL10, IL6, TNF

Sources for Hemorrhagic Fever with Renal Syndrome

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet