Hemorrhagic Fever with Renal Syndrome disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Hemorrhagic Fever with Renal Syndrome

Sources:
⁹Disease Ontology, ⁶⁴Wikipedia, ³²MalaCards
See all sources

Disease Ontology:⁹ A viral infectious disease that is a hemorrhagic fever, located in kidney, has material basis in hantaan virus, has material basis in dobrava-belgrade virus, has material basis in seoul virus, or has material basis in puumala virus, which are carried and transmitted by rodents. the infection has symptom headache, has symptom fever, has symptom muscle pains, has symptom facial flush, has symptom petechiae, has symptom hemorrhagic features, has symptom proteinuria, and has symptom renal failure.

MalaCards based summary: Hemorrhagic Fever with Renal Syndrome, also known as hantavirus fever, is related to hemorrhagic fever and thrombocytopenia, and has symptoms including abnormality of temperature regulation, renal insufficiency and abnormality of the renal tubule. An important gene associated with Hemorrhagic Fever with Renal Syndrome is HLA-DRB4 (major histocompatibility complex, class II, DR beta 4), and among its related pathways are Immune response Antigen presentation by MHC class II and Staphylococcus aureus infection. The compounds clopidogrel and obtustatin have been mentioned in the context of this disorder. Affiliated tissues include kidney, kidney and lung.

Wikipedia:⁶⁴ Hantavirus hemorrhagic fever with renal syndrome (HFRS) is a group of clinically similar illnesses... more...

Aliases & Classifications for Hemorrhagic Fever with Renal Syndrome

Sources:
⁹Disease Ontology, ¹¹DISEASES, ⁴⁸Orphanet, ⁶¹UMLS, ²⁸ICD9CM, ³⁴MeSH, ⁵⁶SNOMED-CT, ³⁹NCIt, ³⁵MESH via Orphanet, ²⁷ICD10 via Orphanet, ⁶²UMLS via Orphanet, ²⁶ICD10
See all sources

Hemorrhagic Fever with Renal Syndrome, Aliases & Descriptions:

Name: Hemorrhagic Fever with Renal Syndrome ⁹ ¹¹ ⁶¹

Hantavirus Fever ⁴⁸ ⁶¹

Hantavirosis ⁴⁸ ⁶¹

Haemorrhagic Fever with Renal Syndrome ⁶¹

Hemorrhagic Fever - Renal Syndrome ⁴⁸

Hemorrhagic Nephrosonephritis ⁹

Hemorrhagic Fever, Russian ⁹

Puumala Virus Nephropathy ⁹

Hfrs ⁹

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases, Rare diseases
Anatomical: Nephrological diseases

ICD10: ²⁷ ²⁶

Certain infectious and parasitic diseases

Arthropod-borne viral fevers and viral haemorrhagic fevers

Other viral haemorrhagic fevers, not elsewhere classified

Haemorrhagic fever with renal syndrome

Orphanet: ⁴⁸

Rare infectious diseases

External Ids:

Disease Ontology⁹ DOID:11266

ICD9CM²⁸ 078.6

MeSH³⁴ D006480

NCIt³⁹ C84753

SNOMED-CT⁵⁶ 186701001, 364756009, 102455002 70826003, more

MESH via Orphanet³⁵ C535630, D006480

ICD10 via Orphanet²⁷ A98.5+, N08.0*

UMLS via Orphanet⁶² C0019101, C2930957

ICD10²⁶ A98.5

UMLS⁶¹ C0019101

Related Diseases for Hemorrhagic Fever with Renal Syndrome

Sources:
¹⁸GeneCards, ¹⁹GeneDecks
See all sources

Diseases related to Hemorrhagic Fever with Renal Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50) (show all 55)

id	Related Disease	Score	Top Affiliating Genes
1	hemorrhagic fever	32.9	CD40LG
2	thrombocytopenia	30.3	ITGB3, ITGA2B, CD40LG
3	nephropathia epidemica	10.8
4	hantavirus pulmonary syndrome	10.6
5	korean hemorrhagic fever	10.6
6	acute pancreatitis	10.6
7	pancreatitis	10.6
8	hypopituitarism	10.5
9	hypertension	10.4
10	viral hemorrhagic fever	10.4
11	endotheliitis	10.4
12	acute myocardial infarction	10.3
13	alport syndrome	10.3
14	hemophagocytic lymphohistiocytosis	10.3
15	hepatitis	10.3
16	hepatitis b	10.3
17	myocardial infarction	10.3
18	leptospirosis	10.3
19	orchitis	10.3
20	scrub typhus	10.3
21	crimean-congo hemorrhagic fever	10.3
22	balkan hemorrhagic fever	10.3
23	metabolic acidosis	10.3
24	arteriovenous malformation	10.3
25	disseminated intravascular coagulation	10.3
26	labyrinthitis	10.3
27	peritonitis	10.3
28	typhus	10.3
29	hereditary pancreatitis	10.3
30	toxic epidermal necrolysis	10.3
31	pulmonary function	10.3
32	blindness	10.3
33	autoimmune thyroiditis	10.2	CD58, HLA-DRB4
34	autoimmune thrombocytopenic purpura	10.1	ITGA2B, ITGB3
35	bleeding disorder, platelet-type, 16, autosomal dominant	10.1	ITGB3, ITGA2B
36	glanzmann's thrombasthenia	10.1	ITGB3, ITGA2B
37	bernard-soulier syndrome	10.1	ITGA2B, ITGB3
38	primary biliary cirrhosis	10.1	CD58, CD40LG
39	systemic scleroderma	10.1	CD58, CD40LG
40	tetanus	10.0	CD40LG, CD58
41	hypersensitivity reaction type ii disease	10.0	CD58, CD40LG, HLA-DRB4
42	lupus nephritis	10.0	VTN, CD40LG
43	berger disease	10.0	CD40LG, VTN
44	diabetic retinopathy	9.9	VTN, ITGB3
45	nephritis	9.9	VTN, CD40LG
46	multiple sclerosis	9.8	VTN, HLA-DRB5, CD58
47	viral infectious disease	9.8	VTN, CD40LG, CD58
48	glomerulonephritis	9.8	VTN, CD40LG
49	diabetes mellitus	9.8	VTN, CD40LG, ITGA2B
50	acute erythroid leukemia	9.8	ITGA2B, ITGB3, VTN

Graphical network of the top 20 diseases related to Hemorrhagic Fever with Renal Syndrome:

Symptoms for Hemorrhagic Fever with Renal Syndrome

Sources:
⁵⁸The Human Phenotype Ontology, ⁴⁸Orphanet, ⁹Disease Ontology
See all sources

Symptoms:

⁴⁸ ⁹ (show all 39)

fever/chilling
asthenia/fatigue/weakness
chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis
conjunctival injection/chemosis/red eye
photophobia
acute abdominal pain/colic
abnormal hepatic enzymes/transaminases
abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
lung/pulmonary infiltrates
respiratory distress/dyspnea/respiratory failure/lung volume reduction
atelectasia/pulmonary collapse
renal tubular defect/tubulopathy
interstitial nephropathy
renal failure
proteinuria
pollakiuria/polyuria/dysuria/anuria/acute urine retention/oliguria
facial pain/cephalalgia/migraine
myalgia/muscular pain
articular/joint pain/arthralgia
hyperleukocytosis/leukocytosis

thrombocytopenia/thrombopenia
hypoproteinemia
transient amaurosis/acute visual trouble
myopia
gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
hemoptysis
myocardium anomalies/myocarditis
pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
cardiac rhythm disorder/arrhythmia
chronic arterial hypertension
hypotension
intracranial/cerebral/meningeal hemorrhage
early death/lethality
headache
fever
muscle pains
facial flush
petechiae
hemorrhagic features

HPO human phenotypes related to Hemorrhagic Fever with Renal Syndrome:

(show all 28)

id	Description	Frequency	HPO Source Accession
1	abnormality of temperature regulation	hallmark (90%)	HP:0004370
2	renal insufficiency	typical (50%)	HP:0000083
3	abnormality of the renal tubule	typical (50%)	HP:0000091
4	proteinuria	typical (50%)	HP:0000093
5	conjunctivitis	typical (50%)	HP:0000509
6	photophobia	typical (50%)	HP:0000613
7	thrombocytopenia	typical (50%)	HP:0001873
8	leukocytosis	typical (50%)	HP:0001974
9	abdominal pain	typical (50%)	HP:0002027
10	migraine	typical (50%)	HP:0002076
11	respiratory insufficiency	typical (50%)	HP:0002093
12	abnormality of the pleura	typical (50%)	HP:0002103
13	pulmonary infiltrates	typical (50%)	HP:0002113
14	arthralgia	typical (50%)	HP:0002829
15	elevated hepatic transaminases	typical (50%)	HP:0002910
16	hypoproteinemia	typical (50%)	HP:0003075
17	myalgia	typical (50%)	HP:0003326
18	atelectasis	typical (50%)	HP:0100750
19	myopia	occasional (7.5%)	HP:0000545
20	hypertension	occasional (7.5%)	HP:0000822
21	abnormality of the myocardium	occasional (7.5%)	HP:0001637
22	abnormality of the pericardium	occasional (7.5%)	HP:0001697
23	hemoptysis	occasional (7.5%)	HP:0002105
24	intracranial hemorrhage	occasional (7.5%)	HP:0002170
25	gastrointestinal hemorrhage	occasional (7.5%)	HP:0002239
26	hypotension	occasional (7.5%)	HP:0002615
27	arrhythmia	occasional (7.5%)	HP:0011675
28	amaurosis fugax	occasional (7.5%)	HP:0100576

Drugs & Therapeutics for Hemorrhagic Fever with Renal Syndrome

Sources:
⁴¹NIH Clinical Center, ⁶ClinicalTrials
See all sources

Drug clinical trials:

Search ClinicalTrials for Hemorrhagic Fever with Renal Syndrome

Search NIH Clinical Center for Hemorrhagic Fever with Renal Syndrome

Genetic Tests for Hemorrhagic Fever with Renal Syndrome

Anatomical Context for Hemorrhagic Fever with Renal Syndrome

Sources:
³²MalaCards, ¹⁵FMA
See all sources

MalaCards organs/tissues related to Hemorrhagic Fever with Renal Syndrome:

³²

Kidney, Lung, T cells, Eye, Testes, B cells, Endothelial, Heart, Liver, Pancreas, Neutrophil

FMA organs/tissues related to Hemorrhagic Fever with Renal Syndrome:

¹⁵

Kidney

Animal Models for Hemorrhagic Fever with Renal Syndrome or affiliated genes

Publications for Hemorrhagic Fever with Renal Syndrome

Sources:
⁵¹PubMed
See all sources

Articles related to Hemorrhagic Fever with Renal Syndrome:

(show top 50) (show all 330)

id	Title	Authors	Year
1	Increased risk for lymphoma following hemorrhagic fever with renal syndrome. (24965350)	KlingstrAPm J.... Ljunggren H.G.	2014
2	Animal reservoir, natural and socioeconomic variations and the transmission of hemorrhagic Fever with renal syndrome in chenzhou, china, 2006-2010. (24421910)	Xiao H.... Grenfell B.	2014
3	Ecology and geography of hemorrhagic fever with renal syndrome in Changsha, China. (23819824)	Xiao H.... Zhao J.	2013
4	Hemorrhagic fever with renal syndrome and Crimean-Congo hemorrhagic fever as causes of acute undifferentiated febrile illness in Bulgaria. (23421884)	Christova I.... Mohareb E.	2013
5	A case of ruptured renal cortical arteriovenous malformation of the right testicular vein in hemorrhagic fever with renal syndrome. (23682233)	Lee S.M.... Noh J.W.	2013
6	A retrospective study of acute pancreatitis in patients with hemorrhagic fever with renal syndrome. (24345089)	Zhu Y.... Lu N.H.	2013
7	Serum TNF-I+, sTNFR1, IL-6, IL-8 and IL-10 levels in hemorrhagic fever with renal syndrome. (23603136)	Kyriakidis I.... Papa A.	2013
8	Correction: Investigating the Effects of Food Available and Climatic Variables on the Animal Host Density of Hemorrhagic Fever with Renal Syndrome in Changsha, China. (24058426)	Xiao H.... Tian H.Y.	2013
9	Hantavirus infection--hemorrhagic fever with renal syndrome: the first case series reported in Romania and review of the literature. (21678038)	Maftei I.D.... Covic A.	2012
10	Experience with extrarenal manifestations of hemorrhagic fever with renal syndrome in a tertiary care hospital in South Korea. (21292889)	Park K.H.... Jung S.I.	2011
11	Increased serum fibronectin levels in patients with hemorrhagic fever with renal syndrome. (19701604)	Han Q.... Liu Z.	2010
12	Collective immunity of the population from endemic zones of hemorrhagic fever with renal syndrome in Kosovo. (20088164)	MuAsaj S.... Avsic-Zupanc T.	2009
13	Renal artery embolization of perirenal hematoma in hemorrhagic fever with renal syndrome: a case report. (17673847)	Choi H.S.... Yoon Y.	2007
14	Dynamic changes of apoptosis-inducing ligands and Th1/Th2 like subpopulations in Hantaan virus-induced hemorrhagic fever with renal syndrome. (16616877)	Liu J.M.... Jin B.Q.	2006
15	Comparison of virulence of various hantaviruses related to hemorrhagic fever with renal syndrome in newborn mouse model. (15070039)	Lokugamage K.... Takashima I.	2004
16	Hemorrhagic fever with renal syndrome: imported or native disease in the Zadar region]. (15011474)	Dzelalija B.... Avsic-Zupanc T.	2003
17	Hemorrhagic fever with renal syndrome presenting with intrauterine fetal death. A case report. (12971153)	Ma R.M.... Lao T.T.	2003
18	Serological analysis of hemorrhagic fever with renal syndrome (HFRS) patients in Far Eastern Russia and identification of the causative hantavirus genotype. (12898330)	Miyamoto H.... Takashima I.	2003
19	Hemorrhagic fever with renal syndrome: diagnostic problems with a known disease. (11526193)	Wichmann D.... Feldmann H.	2001
20	A case of torsade de pointes associated with hypopituitarism due to hemorrhagic fever with renal syndrome. (11410700)	Kim N.H.... Kang J.C.	2001
21	Epidemiological progresses of hemorrhagic fever with renal syndrome in China. (11593522)	Song G.	1999
22	Direct genetic detection of Dobrava virus in Greek and Albanian patients with hemorrhagic fever with renal syndrome. (8699076)	Antoniadis A.... Spiropoulou C.F.	1996
23	Genetic identification of a new Puumala virus strain causing severe hemorrhagic fever with renal syndrome in Germany. (7995985)	Pilaski J.... Nichol S.T.	1994
24	Virus-related acute renal failure: the clinical course and outcome of hemorrhagic fever with renal syndrome. (7914707)	Siamopoulos K.C.	1994
25	Elevated levels of total and Puumala virus-specific immunoglobulin E in the Scandinavian type of hemorrhagic fever with renal syndrome. (7496961)	Alexeyev O.A.... Juto P.	1994
26	Epidemiologic surveillance on the hemorrhagic fever with renal syndrome in China. (7908258)	Chen H.X.... Qiu F.X.	1993
27	Comparison of European isolates of viruses causing hemorrhagic fever with renal syndrome by a neutralization test. (1684888)	Niklasson B.... Tkachenko E.	1991
28	Effect of glucocorticoid hormones on the status of the hypothalamo-hypophyseal-adrenal system and endocrine function of the pancreas in patients with hemorrhagic fever with renal syndrome]. (1977953)	BystrovskiA- V.F.	1990
29	Hemorrhagic fever with renal syndrome: MR imaging of the kidney. (1971450)	Kim S.H.... Kim C.W.	1990
30	Outbreak of hemorrhagic fever with renal syndrome among U.S. Marines in Korea. (1973603)	Pon E.... Ksiazek T.G.	1990
31	Hemorrhagic fever with renal syndrome. (2647265)	Gan S.	1989
32	What is new and where are the problems in research on hemorrhagic fever with renal syndrome? (2573193)	Hsiang C.M.	1989
33	A clinical study of hemorrhagic fever with renal syndrome caused by Seoul virus infection. (2577257)	Park S.C.... Lee H.W.	1989
34	Hemorrhagic fever with renal syndrome. (2573914)	Lee H.W.... van der Groen G.	1989
35	Hemorrhagic fever with renal syndrome in Korea. (2568676)	Lee H.W.	1989
36	Role of maternal antibody in protection from hemorrhagic fever with renal syndrome virus infection in rats. (2905596)	Zhang X.K.... Hashimoto N.	1988
37	Antibody to hemorrhagic fever with renal syndrome viruses (Hantaviruses) in the United States. (2891295)	Forthal D.N.... McCormick J.B.	1987
38	Cats--source of protection or infection? A case-control study of hemorrhagic fever with renal syndrome. (2889355)	Xu Z.Y.... Tsai T.F.	1987
39	Characterization of glycoproteins of viruses causing hemorrhagic fever with renal syndrome (HFRS) using monoclonal antibodies. (2422813)	Dantas J.R.... Yamanishi K.	1986
40	Hemorrhagic fever with renal syndrome--a clinical perspective. (2867491)	McKee K.T.... Peters C.J.	1985
41	Isolation of a virus related to hemorrhagic fever with renal syndrome from urban rats in a nonendemic area. (6143783)	Sugiyama K.... Kitamura T.	1984
42	Antigenic differences between two viruses, isolated in Japan and Korea, that cause hemorrhagic fever with renal syndrome. (6207309)	Yamanishi K.... Tanishita O.	1984
43	Features of circulation of hemorrhagic fever with renal syndrome (HFRS) virus among small mammals in the European U.S.S.R. (6220688)	Gavrilovskaya I.N.... Chumakov M.P.	1983
44	Isolation of hemorrhagic fever with renal syndrome (HFRS) virus from a tumor specimen in a rat. (6146307)	Yamanishi K.... Kurata T.	1983
45	A preliminary report on hemorrhagic fever with renal syndrome in China. (6137329)	Jiang Y.T.	1983
46	Detection of antibody against hemorrhagic fever with renal syndrome (HFRS) virus in sera of house rats captured in port areas of Japan. (6408289)	Morita C.... Sakakibara H.	1983
47	Hemorrhagic fever with renal syndrome (HFRS). (6134332)	Lee H.W.	1982
48	Hemorrhagic fever with renal syndrome in Finland: ecology and virology of nephropathia epidemica. (6134333)	Brummer-Korvenkontio M.... Vaheri A.	1982
49	Seroepidemiologic study of epidemic hemorrhagic fever with renal syndrome in China. (6114815)	Jiang Y.T.... Song G.C.	1981
50	GEOGRAPHICAL DISTRIBUTION OF HEMORRHAGIC FEVER WITH RENAL SYNDROME. (14196952)	POVALISHINA T.P.... YANKOVSKII A.K.	1964

Genes related to Hemorrhagic Fever with Renal Syndrome

Sources:
¹⁸GeneCards, ¹antibodies-online, ⁴⁵Novus Biologicals
See all sources

Genes related to Hemorrhagic Fever with Renal Syndrome:

- Elite gene

id	Symbol	Description	Score	Implication
1	HLA-DRB4	major histocompatibility complex, class II, DR beta 4	21.42	GeneCards inferred via : Publications (show sections)
2	CD58	CD58 molecule	18.56	GeneCards inferred via : Publications (show sections)
3	CD40LG	CD40 ligand	15.70	GeneCards inferred via : Publications (show sections)
4	HLA-DRB5	major histocompatibility complex, class II, DR beta 5	12.85	GeneCards inferred via : Publications (show sections)
5	ITGA2B	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)	9.99	GeneCards inferred via : Publications (show sections)
6	VTN	vitronectin	7.13	GeneCards inferred via : Publications (show sections)
7	ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	4.27	GeneCards inferred via : Publications (show sections)

Products for genes related to Hemorrhagic Fever with Renal Syndrome disease:

id	Company	Proteins	Lysates	Antibodies	Kits and Assays
1	Antibodies-online	5	-	7	6
2	Novus Biologicals	4	7	7	-

Variations for Hemorrhagic Fever with Renal Syndrome

Expression for genes affiliated with Hemorrhagic Fever with Renal Syndrome

Sources:
²BioGPS, ¹⁶Gene Expression Omnibus DataSets
See all sources

Expression patterns in normal tissues for genes affiliated with Hemorrhagic Fever with Renal Syndrome

Search GEO for disease gene expression data for Hemorrhagic Fever with Renal Syndrome.

Pathways for genes affiliated with Hemorrhagic Fever with Renal Syndrome

Sources:
⁴⁹PathCards, ⁵⁹Thomson Reuters, ⁵²QIAGEN, ³⁰KEGG, ⁵⁴Reactome, ³⁷NCBI BioSystems Database, ⁵Cell Signaling Technology, ⁵⁰PharmGKB, ⁶⁰Tocris Bioscience
See all sources

Pathways related to Hemorrhagic Fever with Renal Syndrome according to GeneCards/GeneDecks:

(show all 45)

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	Immune response Antigen presentation by MHC class II⁵⁹ Show member pathways Immune response IL 22 signaling pathway⁵⁹ G protein signaling N RAS regulation pathway⁵⁹ IL-22 Pathway⁵²	9.6	HLA-DRB5, HLA-DRB4
2	Staphylococcus aureus infection³⁰	9.6	HLA-DRB5, HLA-DRB4
3	Rheumatoid arthritis³⁰	9.6	HLA-DRB4, HLA-DRB5
4	TCR signaling⁵⁴ Show member pathways Downstream TCR signaling⁵⁴	9.6	HLA-DRB4, HLA-DRB5
5	CD28 co-stimulation⁵⁴ Show member pathways CTLA4 Signaling⁵² CTLA4 inhibitory signaling⁵⁴ GPVI-mediated activation cascade⁵⁴ CD28 dependent Vav1 pathway⁵⁴ Activation of PKB⁵⁴ CD28 dependent PI3K/Akt signaling⁵⁴ Costimulation by the CD28 family⁵⁴	9.6	HLA-DRB4, HLA-DRB5
6	ICos-ICosL Pathway in T-Helper Cell⁵² Show member pathways CD28 Signaling in T-Helper Cell⁵² Calcium Mediated T-Cell Apoptosis⁵²	9.6	HLA-DRB4, HLA-DRB5
7	MHC class II antigen presentation⁵⁴	9.6	HLA-DRB4, HLA-DRB5
8	Translocation of ZAP-70 to Immunological synapse⁵⁴ Show member pathways Generation of second messenger molecules⁵⁴ PD-1 signaling⁵⁴ Phosphorylation of CD3 and TCR zeta chains⁵⁴	9.6	HLA-DRB4, HLA-DRB5
9	Cell surface interactions at the vascular wall⁵⁴ Show member pathways Tie2 Signaling⁵⁴ PECAM1 interactions⁵⁴	9.5	CD58, ITGB3
10	IL4-mediated signaling events³⁷	9.5	CD40LG, ITGB3
11	Adhesion⁵	9.3	ITGB3, ITGA2B
12	Ephrin B reverse signaling³⁷	9.3	ITGB3, ITGA2B
13	Arf6 signaling events³⁷	9.3	ITGB3, ITGA2B
14	Signaling events mediated by PTP1B³⁷	9.3	ITGA2B, ITGB3
15	Integrin alphaIIb beta3 signaling⁵⁴ Show member pathways GRB2-SOS provides linkage to MAPK signaling for Intergrins⁵⁴ p130Cas linkage to MAPK signaling for integrins⁵⁴ Platelet Aggregation (Plug Formation)⁵⁴	9.3	ITGA2B, ITGB3
16	Signal transduction by L1⁵⁴	9.3	ITGA2B, ITGB3
17	Reelin Pathway (Cajal-Retzius cells)⁵²	9.3	ITGA2B, ITGB3
18	Hypertrophic cardiomyopathy (HCM)³⁰ Show member pathways Arrhythmogenic right ventricular cardiomyopathy (ARVC)³⁰ Arrhythmogenic right ventricular cardiomyopathy³⁷ Dilated cardiomyopathy³⁰	9.3	ITGA2B, ITGB3
19	Platelet Aggregation Inhibitor Pathway, Pharmacodynamics⁵⁰	9.3	ITGA2B, ITGB3
20	Response to elevated platelet cytosolic Ca2+⁵⁴ Show member pathways Platelet degranulation⁵⁴ Disinhibition of SNARE formation⁵⁴	9.3	ITGA2B, ITGB3
21	Inflammatory Response Pathway³⁷	9.2	CD40LG, VTN
22	Epstein-Barr virus infection³⁰	9.2	CD58, HLA-DRB4, HLA-DRB5
23	VEGF Pathway⁶⁰ Show member pathways CCKBR-Gastrin Stimulated Signaling⁵² VEGF Pathway⁵² Development VEGF family signaling⁵⁹ VEGF Family Ligands and Receptor Interactions⁵²	9.1	ITGB3, VTN
24	Integrins in angiogenesis³⁷	9.1	ITGB3, VTN
25	Cell adhesion Endothelial cell contacts by non junctional mechanisms⁵⁹	9.1	VTN, ITGB3
26	Non-integrin membrane-ECM interactions⁵⁴ Show member pathways Proteogylcan syndecan-mediated signaling events³⁷ Laminin interactions⁵⁴ Syndecan interactions⁵⁴	9.1	VTN, ITGB3
27	Elastic fibre formation⁵⁴ Show member pathways Molecules associated with elastic fibres⁵⁴	9.1	ITGB3, VTN
28	Leishmaniasis³⁰ Show member pathways Toxoplasmosis³⁰ Inflammatory bowel disease (IBD)³⁰	9.1	HLA-DRB5, HLA-DRB4, CD40LG
29	Class I MHC mediated antigen processing and presentation⁵⁴ Show member pathways Ubiquitin mediated proteolysis³⁰ Antigen processing- Ubiquitination and Proteasome degradation⁵⁴ Adaptive Immune System⁵⁴	9.1	HLA-DRB5, HLA-DRB4, CD40LG
30	Allograft rejection³⁰ Show member pathways Autoimmune thyroid disease³⁰ Viral myocarditis³⁰ Intestinal immune network for IgA production³⁰ Allograft Rejection³⁷ Asthma³⁰ Type I diabetes mellitus³⁰ Graft-versus-host disease³⁰ CTL Mediated Apoptosis⁵² Antigen processing and presentation³⁰ THC Differentiation Pathway⁵²	9.1	HLA-DRB5, HLA-DRB4, CD40LG
31	RNA Polymerase I Promoter Opening⁵⁴ Show member pathways RNA Polymerase I Transcription⁵⁴ HATs acetylate histones⁵⁴ RNA Polymerase I Chain Elongation⁵⁴ Condensation of Prophase Chromosomes⁵⁴ Golgi Cisternae Pericentriolar Stack Reorganization⁵⁴ Alcoholism³⁰ RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription⁵⁴ RNA Polymerase I Promoter Clearance⁵⁴ MASTL Facilitates Mitotic Progression⁵⁴ Mitotic Prophase⁵⁴ Transcription from mitochondrial promoters⁵⁴ Chromatin modifying enzymes⁵⁴ Systemic lupus erythematosus³⁰ Chromatin organization⁵⁴ Mitochondrial transcription termination⁵⁴ Amyloids⁵⁴ Mitochondrial transcription initiation⁵⁴	9.1	HLA-DRB5, HLA-DRB4, CD40LG
32	Phagosome³⁰	9.1	HLA-DRB5, HLA-DRB4, ITGB3
33	Hemostasis⁵⁴ Show member pathways Platelet activation, signaling and aggregation⁵⁴	8.9	CD58, ITGA2B, ITGB3
34	Cell adhesion molecules (CAMs)³⁰	8.7	HLA-DRB5, HLA-DRB4, CD58, CD40LG
35	Apoptotic Pathways in Synovial Fibroblasts⁵² Show member pathways Actin-Based Motility by Rho Family GTPases⁵² PPAR Pathway⁵² Cellular Apoptosis Pathway⁵² Rac1 Pathway⁵² Glioma Invasiveness⁵² eIF2 Pathway⁵² ERK5 Signaling⁵² p53 Mediated Apoptosis⁵² Mitochondrial Apoptosis⁵² Rap1 Pathway⁵² Telomerase Components in Cell Signaling⁵² Nuclear Receptor Activation by Vitamin-A⁵² DHA Signaling⁵²	8.5	VTN, ITGB3, ITGA2B
36	Integrin cell surface interactions⁵⁴	8.5	ITGA2B, ITGB3, VTN
37	ECM proteoglycans⁵⁴	8.5	ITGA2B, ITGB3, VTN
38	Degradation of the extracellular matrix⁵⁴ Show member pathways Collagen degradation⁵⁴ Extracellular matrix organization⁵⁴	8.5	ITGA2B, ITGB3, VTN
39	PI3K-Akt signaling pathway³⁰	8.5	ITGA2B, ITGB3, VTN
40	Phagocytosis of Microbes⁵²	8.5	ITGA2B, ITGB3, VTN
41	Integrin Pathway⁵² Show member pathways Inhibition of Angiogenesis by TSP1⁵² Transendothelial Migration of Leukocytes⁵² FAK1 Signaling⁵² GnRH Signaling⁵² UPA-UPAR Pathway⁵²	8.5	ITGA2B, ITGB3, VTN
42	Focal adhesion³⁰ Show member pathways HGF Pathway⁵² Integrin-mediated cell adhesion³⁷ Focal Adhesion³⁷ ECM-receptor interaction³⁰	8.5	ITGA2B, ITGB3, VTN
43	GPCR Pathway⁵² Show member pathways Breast Cancer Regulation by Stathmin1⁵² Pancreatic Adenocarcinoma⁵² P2Y Receptor Signaling⁵² Ras Pathway⁵² Paxillin Interactions⁵² NFAT in Immune Response⁵² Estrogen Pathway⁵²	8.4	ITGA2B, ITGB3, HLA-DRB4, HLA-DRB5
44	Actin Nucleation by ARP-WASP Complex⁵² Show member pathways CDC42 Pathway⁵² RhoA Pathway⁵² Actin Nucleation and Branching⁵²	8.4	HLA-DRB5, HLA-DRB4, ITGB3, ITGA2B
45	Hematopoietic cell lineage³⁰	8.4	ITGA2B, ITGB3, HLA-DRB4, HLA-DRB5

Compounds for genes affiliated with Hemorrhagic Fever with Renal Syndrome

Sources:
⁴⁴Novoseek, ⁵⁰PharmGKB, ²⁵HMDB, ¹²DrugBank, ⁶⁰Tocris Bioscience, ²⁹IUPHAR
See all sources

Compounds related to Hemorrhagic Fever with Renal Syndrome according to GeneCards/GeneDecks:

(show all 26)

id	Compound	Score	Top Affiliating Genes
1	clopidogrel⁴⁴ ⁵⁰ ²⁵ ¹²	12.7	CD40LG, ITGB3
2	obtustatin⁶⁰	9.7	ITGB3, ITGA2B
3	a 286982⁶⁰	9.7	ITGB3, ITGA2B
4	bio 1211⁶⁰	9.7	ITGB3, ITGA2B
5	leukadherin 1⁶⁰	9.7	ITGB3, ITGA2B
6	tc-i 15⁶⁰	9.6	ITGB3, ITGA2B
7	rhodostomin⁴⁴	9.5	ITGB3, VTN
8	pmma⁴⁴	9.5	CD40LG, VTN
9	silicone⁴⁴	9.5	CD40LG, VTN
10	glutaraldehyde⁴⁴	9.4	CD40LG, VTN
11	titanium⁴⁴	9.4	ITGB3, VTN
12	dextran sulfate⁴⁴	9.3	VTN, CD40LG
13	thalidomide⁴⁴ ⁵⁰ ⁶⁰ ¹²	12.1	CD40LG, VTN
14	hyaluronic acid⁴⁴ ²⁵	10.1	VTN, CD58, CD40LG
15	aspirin⁴⁴ ⁵⁰ ²⁹ ²⁵	12.0	CD40LG, ITGB3, VTN
16	cisplatin⁴⁴ ⁵⁰ ⁶⁰ ¹²	11.9	CD40LG, CD58, VTN
17	polyethylene glycol⁴⁴	8.9	CD40LG, VTN
18	dexamethasone⁴⁴ ⁵⁰ ²⁹ ¹²	11.8	CD40LG, CD58, VTN
19	aspartate⁴⁴	8.7	CD40LG, ITGB3, VTN
20	lysine⁴⁴	8.4	VTN, ITGB3, ITGA2B, CD58
21	tirofiban⁴⁴ ¹²	9.4	CD40LG, ITGA2B, ITGB3, VTN
22	abciximab⁴⁴ ¹²	9.4	VTN, ITGB3, ITGA2B, CD40LG
23	fibrinogen⁴⁴	8.4	VTN, ITGB3, ITGA2B, CD40LG
24	adp⁴⁴ ²⁹ ²⁵	10.3	VTN, ITGB3, ITGA2B, CD40LG
25	cysteine⁴⁴	8.3	VTN, ITGB3, ITGA2B, CD40LG
26	serine⁴⁴	8.1	VTN, ITGB3, ITGA2B, CD40LG

GO Terms for genes affiliated with Hemorrhagic Fever with Renal Syndrome

Sources:
¹⁷Gene Ontology
See all sources

Cellular components related to Hemorrhagic Fever with Renal Syndrome according to GeneCards/GeneDecks:

(show all 15)

id	Name	GO ID	Score	Top Affiliating Genes
1	MHC class II protein complex	GO:042613	9.8	HLA-DRB5, HLA-DRB4
2	integral component of lumenal side of endoplasmic reticulum membrane	GO:071556	9.8	HLA-DRB4, HLA-DRB5
3	clathrin-coated endocytic vesicle membrane	GO:030669	9.7	HLA-DRB5, HLA-DRB4
4	transport vesicle membrane	GO:030658	9.7	HLA-DRB4, HLA-DRB5
5	ER to Golgi transport vesicle membrane	GO:012507	9.6	HLA-DRB5, HLA-DRB4
6	platelet alpha granule membrane	GO:031092	9.6	ITGA2B, ITGB3
7	trans-Golgi network membrane	GO:032588	9.6	HLA-DRB4, HLA-DRB5
8	late endosome membrane	GO:031902	9.6	HLA-DRB4, HLA-DRB5
9	integrin complex	GO:008305	9.5	ITGA2B, ITGB3
10	endocytic vesicle membrane	GO:030666	9.5	HLA-DRB4, HLA-DRB5
11	alphav-beta3 integrin-vitronectin complex	GO:071062	9.4	ITGB3, VTN
12	external side of plasma membrane	GO:009897	8.8	CD40LG, ITGA2B, HLA-DRB4, HLA-DRB5
13	integral component of plasma membrane	GO:005887	8.4	HLA-DRB4, ITGB3, ITGA2B, CD58, CD40LG
14	extracellular vesicular exosome	GO:070062	7.9	HLA-DRB5, VTN, ITGB3, CD58
15	plasma membrane	GO:005886	7.8	HLA-DRB5, HLA-DRB4, ITGB3, ITGA2B, CD58, CD40LG

Biological processes related to Hemorrhagic Fever with Renal Syndrome according to GeneCards/GeneDecks:

(show all 27)

id	Name	GO ID	Score	Top Affiliating Genes
1	regulation of interleukin-4 production	GO:032673	10.0	HLA-DRB4, HLA-DRB5
2	regulation of interleukin-10 secretion	GO:2001179	9.9	HLA-DRB4, HLA-DRB5
3	immunoglobulin production involved in immunoglobulin mediated immune response	GO:002381	9.9	HLA-DRB4, HLA-DRB5
4	humoral immune response mediated by circulating immunoglobulin	GO:002455	9.9	HLA-DRB4, HLA-DRB5
5	T-helper 1 type immune response	GO:042088	9.9	HLA-DRB5, HLA-DRB4
6	inflammatory response to antigenic stimulus	GO:002437	9.9	HLA-DRB4, HLA-DRB5
7	detection of bacterium	GO:016045	9.9	HLA-DRB4, HLA-DRB5
8	positive regulation of insulin secretion involved in cellular response to glucose stimulus	GO:035774	9.9	HLA-DRB5, HLA-DRB4
9	negative regulation of interferon-gamma production	GO:032689	9.9	HLA-DRB5, HLA-DRB4
10	negative regulation of T cell proliferation	GO:042130	9.9	HLA-DRB4, HLA-DRB5
11	protein tetramerization	GO:051262	9.8	HLA-DRB4, HLA-DRB5
12	interferon-gamma-mediated signaling pathway	GO:060333	9.8	HLA-DRB5, HLA-DRB4
13	T cell costimulation	GO:031295	9.7	HLA-DRB4, HLA-DRB5
14	platelet aggregation	GO:070527	9.6	ITGA2B, ITGB3
15	leukocyte migration	GO:050900	9.5	CD58, ITGB3
16	T cell receptor signaling pathway	GO:050852	9.5	HLA-DRB4, HLA-DRB5
17	integrin-mediated signaling pathway	GO:007229	9.4	ITGA2B, ITGB3
18	positive regulation of vascular endothelial growth factor receptor signaling pathway	GO:030949	9.4	VTN, ITGB3
19	platelet degranulation	GO:002576	9.3	ITGB3, ITGA2B
20	antigen processing and presentation of exogenous peptide antigen via MHC class II	GO:019886	9.3	HLA-DRB4, HLA-DRB5
21	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.2	ITGB3, VTN
22	platelet activation	GO:030168	9.2	CD40LG, ITGA2B, ITGB3
23	blood coagulation	GO:007596	9.1	CD58, ITGA2B, ITGB3
24	immune response	GO:006955	9.0	VTN, HLA-DRB4, HLA-DRB5
25	cell-matrix adhesion	GO:007160	8.9	ITGA2B, ITGB3, VTN
26	extracellular matrix organization	GO:030198	8.7	VTN, ITGB3, ITGA2B
27	cell adhesion	GO:007155	8.5	VTN, ITGB3, ITGA2B, CD58