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HFRS
MCID: HMR004
MIFTS: 46

Hemorrhagic Fever with Renal Syndrome (HFRS) malady

Infectious category
41 symptoms, 42 genes, 1 tissue, 113 related diseases, clinical trials.

Summaries for Hemorrhagic Fever with Renal Syndrome

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8Disease Ontology, 64Wikipedia, 33MalaCards
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Disease Ontology:8 A viral infectious disease that is a hemorrhagic fever, located in kidney, has material basis in hantaan virus, has material basis in dobrava-belgrade virus, has material basis in seoul virus, or has material basis in puumala virus, which are carried and transmitted by rodents. the infection has symptom headache, has symptom fever, has symptom muscle pains, has symptom facial flush, has symptom petechiae, has symptom hemorrhagic features, has symptom proteinuria, and has symptom renal failure.

MalaCards: Hemorrhagic Fever with Renal Syndrome, also known as hantavirosis, is related to hemorrhagic fever and acute pancreatitis, and has symptoms including fever/chilling, asthenia/fatigue/weakness and chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis. An important gene associated with Hemorrhagic Fever with Renal Syndrome is HLA-DRB4 (major histocompatibility complex, class II, DR beta 4), and among its related pathways are Rheumatoid arthritis and GRB2:SOS provides linkage to MAPK signaling for Intergrins . The compounds a 286982 and obtustatin have been mentioned in the context of this disorder. Affiliated tissues include kidney, and related mouse phenotypes are immune system and hematopoietic system.

Wikipedia:64 Hantavirus hemorrhagic fever with renal syndrome (HFRS) is a group of clinically similar illnesses... more...

Aliases & Classifications for Hemorrhagic Fever with Renal Syndrome

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Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 49Orphanet, 57SNOMED-CT, 40NCIt, 35MeSH, 27ICD9CM, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious
ICD10: 26


Aliases & Descriptions:

hemorrhagic fever with renal syndrome 8 10 61
hantavirosis 49 61
hemorrhagic fever - renal syndrome 49
hemorrhagic nephrosonephritis 8
hemorrhagic fever, russian 8
puumala virus nephropathy 8
hantavirus fever 49
hfrs 8


External Ids:

Disease Ontology8 DOID:11266
NCIt40 C84753
MeSH35 D006480
ICD9CM27 078.6
MESH via Orphanet36 C535630, D006480
ICD10 via Orphanet26 A98.5
SNOMED-CT via Orphanet58 102455002, 364756009
UMLS via Orphanet62 C0019101, C2930957

Related Diseases for Hemorrhagic Fever with Renal Syndrome

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17GeneCards, 18GeneDecks
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Diseases related to Hemorrhagic Fever with Renal Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 113)
idRelated DiseaseScoreTop Affiliating Genes
1hemorrhagic fever32.2CD40LG
2acute pancreatitis30.8GPT, ITGAM
3acute myocardial infarction30.3ITGA2B, ITGAM
4hepatitis c30.3CD40LG, RNPC3, GPT
5thrombocytopenia30.3ITGB3, ITGA2B, CD40LG, GPT, SLPI
6n syndrome11.1
7char syndrome10.8
8nephropathia epidemica10.7
9viral hemorrhagic fever10.7
10korean hemorrhagic fever10.6
11hantavirus pulmonary syndrome10.6
12west syndrome10.5
13balkan hemorrhagic fever10.5
14kid syndrome10.5
15bod syndrome10.4
16german syndrome10.4
17diabetic nephropathy10.2
18alport syndrome10.2
19hemophagocytic lymphohistiocytosis10.2
20arteriovenous malformation10.2
21crimean-congo hemorrhagic fever10.2
22leptospirosis10.2
23orchitis10.2
24balkan nephropathy10.2
25capillary leak syndrome10.2
26scrub typhus10.2
27metabolic acidosis10.2
28hepatitis a10.2
29typhus10.2
30micro syndrome10.2
31hereditary pancreatitis10.2
32toxic epidermal necrolysis10.2
33image syndrome10.2
34hepatitis c virus10.2
35pulmonary function10.2
36stroke, hemorrhagic10.2
37lupus erythematosus10.0CD40LG
38crohn's disease10.0ITGA4
39vascular disease10.0ITGAM
40antiphospholipid syndrome10.0CD40LG
41influenza10.0RNPC3
42dengue hemorrhagic fever10.0CD40LG
43tuberculosis10.0ITGAM
44myeloid leukemia10.0ITGAM
45connective tissue disease10.0CD40LG
46toxoplasmosis10.0CD40LG
47acquired immunodeficiency syndrome10.0B2M
48diabetic retinopathy10.0VTN, ITGB3
49autoimmune thrombocytopenic purpura10.0ITGA2B, ITGB3
50mixed connective tissue disease10.0RNPC3

Graphical network of the top 20 diseases related to Hemorrhagic Fever with Renal Syndrome:



Diseases related to hemorrhagic fever with renal syndrome

Clinical Features for Hemorrhagic Fever with Renal Syndrome

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49Orphanet
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Symptoms:

49 (show all 39)
  • fever/chilling
  • asthenia/fatigue/weakness
  • chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis
  • conjunctival injection/chemosis/red eye
  • photophobia
  • acute abdominal pain/colic
  • abnormal hepatic enzymes/transaminases
  • abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
  • lung/pulmonary infiltrates
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • atelectasia/pulmonary collapse
  • renal tubular defect/tubulopathy
  • interstitial nephropathy
  • renal failure
  • proteinuria
  • pollakiuria/polyuria/dysuria/anuria/acute urine retention/oliguria
  • facial pain/cephalalgia/migraine
  • myalgia/muscular pain
  • articular/joint pain/arthralgia
  • hyperleukocytosis/leukocytosis
  • thrombocytopenia/thrombopenia
  • hypoproteinemia
  • transient amaurosis/acute visual trouble
  • myopia
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • hemoptysis
  • myocardium anomalies/myocarditis
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
  • cardiac rhythm disorder/arrhythmia
  • chronic arterial hypertension
  • hypotension
  • intracranial/cerebral/meningeal hemorrhage
  • early death/lethality
  • headache
  • fever
  • muscle pains
  • facial flush
  • petechiae
  • hemorrhagic features

Drugs & Therapeutics for Hemorrhagic Fever with Renal Syndrome

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5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Hemorrhagic Fever with Renal Syndrome

Drug clinical trials:

Search ClinicalTrials for Hemorrhagic Fever with Renal Syndrome

Search NIH Clinical Center for Hemorrhagic Fever with Renal Syndrome

Search CenterWatch for Hemorrhagic Fever with Renal Syndrome

Genetic Tests for Hemorrhagic Fever with Renal Syndrome

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Anatomical Context for Hemorrhagic Fever with Renal Syndrome

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14FMA
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FMA organs/tissues related to Hemorrhagic Fever with Renal Syndrome:

14
Kidney

Animal Models for Hemorrhagic Fever with Renal Syndrome or affiliated genes

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37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Hemorrhagic Fever with Renal Syndrome:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1
immune system phenotype
MP:00053879.3ICAM2, CD40LG, CD93, B2M, ITGA2B, ITGB3
2
hematopoietic system phenotype
MP:00053979.0ICAM2, SLPI, CD40LG, B2M, ITGA2B, ITGB3

Publications for Hemorrhagic Fever with Renal Syndrome

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Genetic Variations for Hemorrhagic Fever with Renal Syndrome

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Expression for genes affiliated with Hemorrhagic Fever with Renal Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hemorrhagic Fever with Renal Syndrome

Search GEO for disease gene expression data for Hemorrhagic Fever with Renal Syndrome.

Pathways for genes affiliated with Hemorrhagic Fever with Renal Syndrome

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Sources:
30KEGG, 54Reactome, 4Cell Signaling Technology, 12EMD Millipore, 52QIAGEN, 38NCBI BioSystems Database
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Pathways related to Hemorrhagic Fever with Renal Syndrome according to GeneCards/GeneDecks:

(show all 38)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Rheumatoid arthritis30
10.3HLA-DOB
2
GRB2:SOS provides linkage to MAPK signaling for Intergrins 54
Hide members
10.3ITGA2B, ITGB3
3
Adhesion4
10.2ITGA2B, ITGB3, ITGA4
4
Cell surface interactions at the vascular wall54
10.2ITGB3, ITGAM, ITGA4
5
Immune response Lectin induced complement pathway
Hide members
10.1VTN, CD93, ITGAM
6
MHC class II antigen presentation54
10.1HLA-DRB4, HLA-DOB, HLA-DRB5
7
Immune response Antigen presentation by MHC class II
Hide members
10.1HLA-DRB4, HLA-DOB, HLA-DRB5
8
G-protein signaling N-RAS regulation pathway12
10.1HLA-DRB5, HLA-DOB, HLA-DRB4
9
Immune response T cell receptor signaling pathway12
10.1HLA-DRB5, HLA-DOB, HLA-DRB4
10
Immune response IL-22 signaling pathway12
10.1HLA-DRB4, HLA-DOB, HLA-DRB5
11
Immune response NFAT in immune response
Hide members
10.1HLA-DRB5, HLA-DOB, HLA-DRB4
12
Immune response ICOS pathway in T-helper cell
Hide members
10.1HLA-DRB4, HLA-DOB, HLA-DRB5
13
CD28 co-stimulation54
Hide members
10.1HLA-DRB4, HLA-DOB, HLA-DRB5
14
amb2 Integrin signaling38
10.1VTN, ITGAM, ICAM2
15
Immune response Role of integrins in NK cells cytotoxicity12
10.1ICAM2, ITGA4, ITGAM
16
Classical antibody-mediated complement activation54
Hide members
10.1B2M, ITGA4, ICAM2
17
Platelet activation, signaling and aggregation54
Hide members
10.1ITGA2B, ITGB3, ITGAM, ITGA4
18
Regulation of Actin Cytoskeleton38
Hide members
10.1ITGA4, ITGAM, ITGB3, ITGA2B
19
Reelin Pathway (Cajal-Retzius cells)52
10.1ITGA4, ITGAM, ITGB3, ITGA2B
20
Erythropoietin Pathway52
Hide members
10.1ITGA4, ITGAM, ITGB3, ITGA2B
21
DREAM Repression and Dynorphin Expression52
Hide members
10.1ITGA4, ITGAM, ITGB3, ITGA2B
22
NFAT and Cardiac Hypertrophy52
Hide members
10.1ITGA4, ITGAM, ITGB3, ITGA2B
23
Alcoholism30
Hide members
10.0HLA-DRB5, HLA-DOB, HLA-DRB4, CD40LG
24
Tuberculosis30
10.0HLA-DRB5, HLA-DOB, HLA-DRB4, ITGAM
25
Staphylococcus aureus infection30
10.0HLA-DRB5, HLA-DOB, HLA-DRB4, ITGAM
26
Phagocytosis of Microbes52
9.9ITGA4, ITGAM, ITGB3, ITGA2B, VTN
27
Focal Adhesion38
Hide members
9.9ITGA4, ITGAM, ITGB3, ITGA2B, VTN
28
Apoptotic Pathways in Synovial Fibroblasts52
Hide members
9.9ITGA4, ITGAM, ITGB3, ITGA2B, VTN
29
Phagosome30
9.9HLA-DRB5, HLA-DOB, HLA-DRB4, ITGAM, ITGB3
30
Non-integrin membrane-ECM interactions54
Hide members
9.9ICAM2, ITGA4, ITGB3, ITGA2B, VTN
31
Hematopoietic cell lineage30
9.9HLA-DRB5, HLA-DRB4, ITGA4, ITGAM, ITGB3, ITGA2B
32
Leishmaniasis30
Hide members
9.8HLA-DRB5, HLA-DOB, HLA-DRB4, ITGA4, ITGAM, CD40LG
33
Integrin Pathway52
Hide members
9.8ICAM2, ITGA4, ITGAM, ITGB3, ITGA2B, VTN
34
Allograft rejection30
Hide members
9.8HLA-DRB5, HLA-DOB, HLA-DRB4, ITGA4, B2M, CD40LG
35
GPCR Pathway52
Hide members
9.7HLA-DRB5, HLA-DOB, HLA-DRB4, ITGA4, ITGAM, ITGB3
36
Actin Nucleation by ARP-WASP Complex52
Hide members
9.7HLA-DRB5, HLA-DOB, HLA-DRB4, ITGA4, ITGAM, ITGB3
37
Cell adhesion molecules (CAMs)30
9.7CD40LG, ICAM2, HLA-DRB5, HLA-DOB, HLA-DRB4, ITGA4
38
Immune System54
Hide members
9.6ICAM2, HLA-DRB5, HLA-DOB, HLA-DRB4, ITGA4, ITGAM

Compounds for genes affiliated with Hemorrhagic Fever with Renal Syndrome

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Sources:
60Tocris Bioscience, 45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB, 29IUPHAR, 2BitterDB
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Compounds related to Hemorrhagic Fever with Renal Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 61)
idCompoundScoreTop Affiliating Genes
1a 2869826010.6ITGA2B, ITGB3, ITGA4
2obtustatin6010.6ITGA2B, ITGB3, ITGA4
3bio 12116010.6ITGA4, ITGB3, ITGA2B
4tc-i 156010.6ITGA2B, ITGB3, ITGA4
5leukadherin 16010.6ITGA2B, ITGB3, ITGA4
6rhodostomin4510.6ITGB3, VTN
7lamivudine45 1111.6B2M, SLPI
8hemophan4510.6ITGAM, B2M
9an 694510.6ITGAM, B2M, VTN
10polyacrylonitrile4510.6VTN, B2M, ITGAM
11pmma4510.6B2M, CD40LG, VTN
12iopentol4510.6SLPI, B2M
13cuprophan4510.5VTN, B2M, ITGAM
14tirofiban45 1111.5ITGB3, ITGA2B, CD40LG, VTN
15abciximab45 1111.5VTN, CD40LG, ITGA2B, ITGB3
16sevoflurane45 1111.5SLPI, GPT, B2M
17silicone4510.5CD40LG, RNPC3, VTN
18titanium4510.5ITGB3, SLPI, VTN
19rgd peptide4510.5VTN, ITGA4
20tobramycin4510.4B2M, RNPC3
21phosphorus4510.4SLPI, GPT, B2M
22formaldehyde45 2411.4ITGAM, ITGA2B, B2M, CD40LG
23ivig4510.4GPT, CD40LG, ITGA4
24urea45 11 2412.4VTN, SLPI, GPT, B2M
25aspartate4510.4VTN, GPT, CD40LG, B2M, ITGA4
26hyaluronic acid45 2411.3B2M, CD40LG, GPT, SLPI, VTN
27polysaccharide4510.3ICAM2, ITGAM, B2M, CD40LG, VTN
28aspirin45 50 29 2413.3ITGAM, ITGB3, CD40LG, VTN
29vitamin d4510.3SLPI, GPT, B2M, ITGB3, ITGAM
30rantes4510.3ICAM2, ITGA4, ITGAM, CD40LG, SLPI
31vitamin b124510.3GPT, CD40LG, B2M
32creatinine4510.3ITGAM, GPT, SLPI
33genistein45 29 60 2 11 2415.2ITGA4, ITGAM, B2M, CD40LG, SLPI
34lactate4510.2ITGAM, B2M, CD40LG, GPT, SLPI, VTN
35serine4510.2ITGA4, ITGAM, ITGA2B, B2M, RNPC3, VTN
36pge24510.2ITGAM, B2M, CD40LG, SLPI, VTN
37neopterin4510.2GPT, CD40LG, B2M
38slea4510.2CD40LG, ITGA4
39theophylline45 29 11 2413.2CD40LG, B2M, ITGAM
40cyclosporin a45 29 6012.2ITGAM, B2M, CD40LG, RNPC3, GPT, SLPI
41iron45 2411.1ITGB3, B2M, RNPC3, GPT, SLPI
42dexamethasone45 50 29 1113.1ITGA4, ITGAM, CD93, CD40LG, SLPI, VTN
43vegf4510.1ITGAM, ITGB3, B2M, CD40LG, SLPI, VTN
44cysteine4510.1ITGAM, ITGB3, ITGA2B, B2M, CD40LG, SLPI
45fibrinogen4510.1VTN, ITGA4, ITGAM, ITGB3, ITGA2B, CD40LG
46alanine4510.0ITGB3, B2M, CD40LG, GPT, SLPI, VTN
47heparin45 29 11 2413.0ITGA4, ITGAM, CD40LG, SLPI, VTN
48tyrosine459.7ICAM2, ITGA4, ITGAM, ITGB3, RNPC3, FRS3
49calcium45 50 11 2412.6ICAM2, ITGA4, ITGAM, ITGB3, ITGA2B, B2M
50adenylate459.6ITGAM, CD40LG, RNPC3, GPT, GPR182

GO Terms for genes affiliated with Hemorrhagic Fever with Renal Syndrome

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16Gene Ontology
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Cellular components related to Hemorrhagic Fever with Renal Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule membraneGO:03109210.3ITGA2B, ITGB3
2MHC class II protein complexGO:04261310.2HLA-DRB4, HLA-DOB, HLA-DRB5
3integrin complexGO:00830510.2ITGA4, ITGAM, ITGB3, ITGA2B
4ER to Golgi transport vesicle membraneGO:01250710.1HLA-DRB5, HLA-DRB4, B2M
5alphav-beta3 integrin-vitronectin complexGO:07106210.0VTN, ITGB3
6external side of plasma membraneGO:0098979.9CD40LG, B2M, ITGA2B, ITGAM, ITGA4, HLA-DRB4
7plasma membraneGO:0058869.1ITGAM, ITGA4, HLA-DRB4, HLA-DRB5, ICAM2, ITGB3

Biological processes related to Hemorrhagic Fever with Renal Syndrome according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1regulation of interleukin-4 productionGO:03267310.5HLA-DRB4, HLA-DRB5
2regulation of interleukin-10 secretionGO:200117910.5HLA-DRB4, HLA-DRB5
3immunoglobulin production involved in immunoglobulin mediated immune responseGO:00238110.5HLA-DRB5, HLA-DRB4
4humoral immune response mediated by circulating immunoglobulinGO:00245510.5HLA-DRB5, HLA-DRB4
5leukocyte cell-cell adhesionGO:00715910.4ITGA4, ITGAM, CD40LG
6T-helper 1 type immune responseGO:04208810.4HLA-DRB4, HLA-DRB5
7interferon-gamma-mediated signaling pathwayGO:06033310.4B2M, HLA-DRB4, HLA-DRB5
8integrin-mediated signaling pathwayGO:00722910.4ITGA2B, ITGB3, ITGAM, ITGA4
9cell-matrix adhesionGO:00716010.4VTN, ITGA2B, ITGB3
10inflammatory response to antigenic stimulusGO:00243710.3HLA-DRB5, HLA-DRB4
11regulation of immune responseGO:05077610.3CD40LG, B2M, ITGA4, ICAM2
12antigen processing and presentation of exogenous peptide antigen via MHC class IIGO:01988610.3HLA-DRB5, HLA-DOB, HLA-DRB4
13detection of bacteriumGO:01604510.3HLA-DRB4, HLA-DRB5
14positive regulation of vascular endothelial growth factor receptor signaling pathwayGO:03094910.3VTN, ITGB3
15positive regulation of insulin secretion involved in cellular response to glucose stimulusGO:03577410.2HLA-DRB4, HLA-DRB5
16leukocyte migrationGO:0509009.9ITGA4, ITGAM, ITGB3

Molecular functions related to Hemorrhagic Fever with Renal Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:03239510.2HLA-DRB4, HLA-DOB

Products for genes affiliated with Hemorrhagic Fever with Renal Syndrome

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Sources for Hemorrhagic Fever with Renal Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet
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