HFRS
MCID: HMR004
MIFTS: 65

Hemorrhagic Fever with Renal Syndrome (HFRS) malady

Infectious diseases, Nephrological diseases categories

Summaries for Hemorrhagic Fever with Renal Syndrome

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A viral infectious disease that is a hemorrhagic fever, located in kidney, has material basis in hantaan virus, has material basis in dobrava-belgrade virus, has material basis in seoul virus, or has material basis in puumala virus, which are carried and transmitted by rodents. the infection has symptom headache, has symptom fever, has symptom muscle pains, has symptom facial flush, has symptom petechiae, has symptom hemorrhagic features, has symptom proteinuria, and has symptom renal failure.

MalaCards: Hemorrhagic Fever with Renal Syndrome, also known as hantavirosis, is related to acute pancreatitis and acute myocardial infarction, and has symptoms including chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis, atelectasia/pulmonary collapse and intracranial/cerebral/meningeal hemorrhage. An important gene associated with Hemorrhagic Fever with Renal Syndrome is HLA-DRB4 (major histocompatibility complex, class II, DR beta 4), and among its related pathways are Rheumatoid arthritis and GRB2:SOS provides linkage to MAPK signaling for Intergrins . The compounds a 286982 and obtustatin have been mentioned in the context of this disorder. Affiliated tissues include kidney, kidney and lung, and related mouse phenotypes are immune system and hematopoietic system.

Wikipedia:63 Hantavirus hemorrhagic fever with renal syndrome (HFRS) is a group of clinically similar illnesses... more...

Aliases & Classifications for Hemorrhagic Fever with Renal Syndrome

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Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 48Orphanet, 56SNOMED-CT, 39NCIt, 34MeSH, 27ICD9CM, 35MESH via Orphanet, 57SNOMED-CT via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Nephrological diseases


Aliases & Descriptions:

hemorrhagic fever with renal syndrome 8 10 60
hantavirosis 48 60
hemorrhagic fever - renal syndrome 48
hemorrhagic nephrosonephritis 8
hemorrhagic fever, russian 8
puumala virus nephropathy 8
hantavirus fever 48
hfrs 8


External Ids:

Disease Ontology8 DOID:11266
NCIt39 C84753
MeSH34 D006480
ICD9CM27 078.6
MESH via Orphanet35 C535630, D006480
SNOMED-CT via Orphanet57 102455002, 364756009
ICD10 via Orphanet26 A98.5+, N08.0*
UMLS via Orphanet61 C0019101, C2930957

Related Diseases for Hemorrhagic Fever with Renal Syndrome

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Hemorrhagic Fever with Renal Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 108)
idRelated DiseaseScoreTop Affiliating Genes
1acute pancreatitis30.7ITGAM, GPT
2acute myocardial infarction30.3ITGAM, ITGA2B
3peritonitis30.3B2M, SLPI
4hepatitis b30.3GPT, RNPC3
5myocardial infarction30.3ITGA2B, ITGAM, ITGB3
6hepatitis30.3GPT, VTN
7disseminated intravascular coagulation30.3VTN
8thrombocytopenia30.3SLPI, ITGB3, ITGA2B, CD40LG, GPT
9hemorrhagic disease10.8
10nephropathia epidemica10.7
11korean hemorrhagic fever10.6
12hantavirus pulmonary syndrome10.6
13pancreatitis10.5
14balkan hemorrhagic fever10.4
15hypopituitarism10.4
16image syndrome10.4
17hypertension10.4
18renal hypertension10.4
19diabetic nephropathy10.2
20alport syndrome10.2
21hemophagocytic lymphohistiocytosis10.2
22arteriovenous malformation10.2
23crimean-congo hemorrhagic fever10.2
24west syndrome10.2
25leptospirosis10.2
26orchitis10.2
27balkan nephropathy10.2
28scrub typhus10.2
29metabolic acidosis10.2
30gallbladder disease10.2
31glaucoma10.2
32labyrinthitis10.2
33typhus10.2
34hereditary pancreatitis10.2
35hemorrhagic fever10.0CD40LG
36lupus erythematosus10.0CD40LG
37crohn's disease10.0ITGA4
38vascular disease10.0ITGAM
39antiphospholipid syndrome10.0CD40LG
40influenza10.0RNPC3
41dengue hemorrhagic fever10.0CD40LG
42tuberculosis10.0ITGAM
43myeloid leukemia10.0ITGAM
44toxoplasmosis10.0CD40LG
45connective tissue disease10.0CD40LG
46acquired immunodeficiency syndrome10.0B2M
47diabetic retinopathy10.0VTN, ITGB3
48autoimmune thrombocytopenic purpura10.0ITGB3, ITGA2B
49mixed connective tissue disease10.0RNPC3
50encephalitis10.0ITGA4, ICAM2

Graphical network of the top 20 diseases related to Hemorrhagic Fever with Renal Syndrome:



Diseases related to hemorrhagic fever with renal syndrome

Clinical Features for Hemorrhagic Fever with Renal Syndrome

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Sources:
48Orphanet
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Symptoms:

48 (show all 39)
  • chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis
  • atelectasia/pulmonary collapse
  • intracranial/cerebral/meningeal hemorrhage
  • hemoptysis
  • hyperleukocytosis/leukocytosis
  • hypoproteinemia
  • conjunctival injection/chemosis/red eye
  • fever
  • headache
  • muscle pains
  • facial flush
  • petechiae
  • hemorrhagic features
  • renal tubular defect/tubulopathy
  • abnormal hepatic enzymes/transaminases
  • myopia
  • interstitial nephropathy
  • renal failure
  • asthenia/fatigue/weakness
  • proteinuria
  • photophobia
  • early death/lethality
  • chronic arterial hypertension
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • pollakiuria/polyuria/dysuria/anuria/acute urine retention/oliguria
  • fever/chilling
  • articular/joint pain/arthralgia
  • cardiac rhythm disorder/arrhythmia
  • transient amaurosis/acute visual trouble
  • facial pain/cephalalgia/migraine
  • thrombocytopenia/thrombopenia
  • abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
  • myocardium anomalies/myocarditis
  • lung/pulmonary infiltrates
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
  • acute abdominal pain/colic
  • myalgia/muscular pain
  • hypotension

Drugs & Therapeutics for Hemorrhagic Fever with Renal Syndrome

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Hemorrhagic Fever with Renal Syndrome

Drug clinical trials:

Search ClinicalTrials for Hemorrhagic Fever with Renal Syndrome

Search NIH Clinical Center for Hemorrhagic Fever with Renal Syndrome

Search CenterWatch for Hemorrhagic Fever with Renal Syndrome

Genetic Tests for Hemorrhagic Fever with Renal Syndrome

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Anatomical Context for Hemorrhagic Fever with Renal Syndrome

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Hemorrhagic Fever with Renal Syndrome:

32
Kidney, Lung, T cells, Testes, Eye, Endothelial, B cells, Heart, Liver, Pancreas

FMA organs/tissues related to Hemorrhagic Fever with Renal Syndrome:

14
Kidney

Animal Models for Hemorrhagic Fever with Renal Syndrome or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Hemorrhagic Fever with Renal Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053879.3UBASH3A, ITGA4, ITGAM, ITGB3, ITGA2B, B2M
2MP:00053979.0VTN, ICAM2, UBASH3A, ITGA4, ITGAM, ITGB3

Publications for Hemorrhagic Fever with Renal Syndrome

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Sources:
50PubMed
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Articles related to Hemorrhagic Fever with Renal Syndrome:

(show top 50)    (show all 318)
idTitleAuthorsYear
1
Ecology and geography of hemorrhagic fever with renal syndrome in Changsha, China. (23819824)
2013
2
Hemorrhagic fever with renal syndrome and Crimean-Congo hemorrhagic fever as causes of acute undifferentiated febrile illness in Bulgaria. (23421884)
2013
3
Serum TNF-I+, sTNFR1, IL-6, IL-8 and IL-10 levels in hemorrhagic fever with renal syndrome. (23603136)
2013
4
Epidemiology of hemorrhagic fever with renal syndrome in Korea, 2001-2010. (24133366)
2013
5
Acute pancreatitis associated with hemorrhagic fever with renal syndrome: clinical analysis of 12 cases. (23964665)
2013
6
Sustained high level of serum VEGF at convalescent stage contributes to the renal recovery after HTNV infection in patients with hemorrhagic fever with renal syndrome. (23097674)
2012
7
Toxic epidermal necrolysis with ocular involvement following vaccination for hemorrhagic fever with renal syndrome. (22187258)
2012
8
Application of an autoregressive integrated moving average model for predicting the incidence of hemorrhagic fever with renal syndrome. (22855772)
2012
9
Comparison of Hantaan and Seoul viral infections among patients with hemorrhagic fever with renal syndrome (HFRS) in Heilongjiang, China. (21428852)
2011
10
Evidence of disseminated intravascular coagulation in a hemorrhagic fever with renal syndrome-scoring models and severe illness. (21731657)
2011
11
Hantavirus-specific IgA in saliva and viral antigen in the parotid gland in patients with hemorrhagic fever with renal syndrome. (21360546)
2011
12
Imaging of hemorrhagic fever with renal syndrome: a potential bioterrorism agent of military significance. (22165665)
2011
13
Hemorrhagic fever with renal syndrome, Vietnam. (20113591)
2010
14
Hemorrhagic fever with renal syndrome in 4 US soldiers, South Korea, 2005. (19891878)
2009
15
The detection of sLFA-3 in plasma of patients with hemorrhagic fever with renal syndrome. (18820826)
2009
16
Domestically acquired seoul virus causing hemorrhagic fever with renal syndrome-Maryland, 2008. (19848600)
2009
17
Puumala hantavirus viremia diagnosed by real-time reverse transcriptase PCR using samples from patients with hemorrhagic fever and renal syndrome. (17537944)
2007
18
Characterization of hemorrhagic fever with renal syndrome caused by hantaviruses, Estonia. (18217569)
2007
19
Hemorrhagic fever with renal syndrome complicated with pregnancy: a case report. (16913449)
2006
20
Hanta hemorrhagic fever with renal syndrome: a case report and review. (15986074)
2005
21
Rehabilitation therapy of convalescents after hemorrhagic fever with renal syndrome in outpatient clinic]. (15108430)
2004
22
Dobrava hantavirus causes hemorrhagic fever with renal syndrome in central Europe and is carried by two different Apodemus mice species. (11170053)
2001
23
Cellular entry of hantaviruses which cause hemorrhagic fever with renal syndrome is mediated by beta3 integrins. (10196290)
1999
24
Puumala and Dobrava viruses cause hemorrhagic fever with renal syndrome in Bosnia-Herzegovina: evidence of highly cross-neutralizing antibody responses in early patient sera. (9298732)
1997
25
Glomerular basement membrane antibodies in hantavirus disease (hemorrhagic fever with renal syndrome). (9342483)
1997
26
Spontaneous luminol-dependent chemiluminescence of thrombocytes increases in hemorrhagic fever with renal syndrome. (7859419)
1995
27
Hemorrhagic fever with renal syndrome: a study of sequelae following nephropathia epidemica. (7944947)
1994
28
Isolation of a Puumala-like virus from Mus musculus captured in Yugoslavia and its association with severe hemorrhagic fever with renal syndrome. (7506281)
1994
29
Retrospective and prospective studies of hemorrhagic fever with renal syndrome in rural China. (7915747)
1994
30
Serum levels of alpha and gamma interferons in hemorrhagic fever with renal syndrome. (7848512)
1994
31
Hypertension after hemorrhagic fever with renal syndrome. (1356239)
1992
32
Two cases of hyperimmunoglobulinemia E in patients with hemorrhagic fever with renal syndrome. (1679249)
1991
33
Effects of Hantaan virus on human endothelial cells and their significance in pathogenesis of hemorrhagic fever with renal syndrome. (1686857)
1991
34
Effect of glucocorticoid hormones on the status of the hypothalamo-hypophyseal-adrenal system and endocrine function of the pancreas in patients with hemorrhagic fever with renal syndrome]. (1977953)
1990
35
Hemorrhagic fever with renal syndrome. Separation of human peripheral blood T and B cells and detection of viral antigen. (1972048)
1990
36
Role of maternal antibody in protection from hemorrhagic fever with renal syndrome virus infection in rats. (2905596)
1988
37
Virus-specific proteins and RNAs from cells infected with hemorrhagic fever with renal syndrome (HFRS) viruses derived from endemic areas of the U.S.S.R. (2904252)
1988
38
Antibody to hemorrhagic fever with renal syndrome viruses (Hantaviruses) in the United States. (2891295)
1987
39
Effects of human and murine interferons against hemorrhagic fever with renal syndrome (HFRS) virus (Hantaan virus). (2451468)
1987
40
Viruses of hemorrhagic fever with renal syndrome (HFRS) grouped by immunoprecipitation and hemagglutination inhibition. (3117723)
1987
41
Growth experiment of Hantaan virus in A549 cells: an attempt to improve the immunofluorescent antibody technique for hemorrhagic fever with renal syndrome. (2872077)
1986
42
Epidemiological study of hemorrhagic fever with renal syndrome related virus infection among urban rats in two islands in Tokyo Bay, Japan. (2859764)
1985
43
Isolation of a virus related to hemorrhagic fever with renal syndrome from urban rats in a nonendemic area. (6143783)
1984
44
An immune adherence assay for discrimination between etiologic agents of hemorrhagic fever with renal syndrome. (6141206)
1984
45
Serological diagnosis of hemorrhagic fever with renal syndrome in European region of U.S.S.R. (6129499)
1982
46
New hemorrhagic fever with renal syndrome-related virus in rodents in the United States. (6129495)
1982
47
Seroepidemiologic study of epidemic hemorrhagic fever with renal syndrome in China. (6114815)
1981
48
Nephropathia epidemica. The Scandinavian form of hemorrhagic fever with renal syndrome. (18620)
1977
49
Acute glaucoma in hemorrhagic fever with renal syndrome (nephropathia epidemica). (1266924)
1976
50
Demonstration of complement-fixing antigen in hemorrhagic fever with renal syndrome. (5225091)
1966

Genetic Variations for Hemorrhagic Fever with Renal Syndrome

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Expression for genes affiliated with Hemorrhagic Fever with Renal Syndrome

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hemorrhagic Fever with Renal Syndrome

Search GEO for disease gene expression data for Hemorrhagic Fever with Renal Syndrome.

Pathways for genes affiliated with Hemorrhagic Fever with Renal Syndrome

About this section
Sources:
29KEGG, 53Reactome, 4Cell Signaling Technology, 12EMD Millipore, 51QIAGEN, 37NCBI BioSystems Database
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Pathways related to Hemorrhagic Fever with Renal Syndrome according to GeneCards/GeneDecks:

(show all 38)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3HLA-DOB
2
Hide members
10.3ITGA2B, ITGB3
310.2ITGA2B, ITGB3, ITGA4
410.2ITGB3, ITGAM, ITGA4
5
Immune response Lectin induced complement pathway
Hide members
10.1VTN, CD93, ITGAM
610.1HLA-DRB4, HLA-DOB, HLA-DRB5
7
Immune response Antigen presentation by MHC class II
Hide members
10.1HLA-DRB4, HLA-DOB, HLA-DRB5
810.1HLA-DRB5, HLA-DOB, HLA-DRB4
910.1HLA-DRB5, HLA-DOB, HLA-DRB4
1010.1HLA-DRB4, HLA-DOB, HLA-DRB5
11
Immune response NFAT in immune response
Hide members
10.1HLA-DRB5, HLA-DOB, HLA-DRB4
12
Immune response ICOS pathway in T-helper cell
Hide members
10.1HLA-DRB4, HLA-DOB, HLA-DRB5
13
Hide members
10.1HLA-DRB4, HLA-DOB, HLA-DRB5
1410.1VTN, ITGAM, ICAM2
1510.1ICAM2, ITGA4, ITGAM
16
Hide members
10.1B2M, ITGA4, ICAM2
17
Hide members
10.1ITGA2B, ITGB3, ITGAM, ITGA4
18
Hide members
10.1ITGA4, ITGAM, ITGB3, ITGA2B
1910.1ITGA4, ITGAM, ITGB3, ITGA2B
20
Hide members
10.1ITGA4, ITGAM, ITGB3, ITGA2B
21
Hide members
10.1ITGA4, ITGAM, ITGB3, ITGA2B
22
Hide members
10.1ITGA4, ITGAM, ITGB3, ITGA2B
23
Hide members
10.0HLA-DRB5, HLA-DOB, HLA-DRB4, CD40LG
2410.0HLA-DRB5, HLA-DOB, HLA-DRB4, ITGAM
2510.0HLA-DRB5, HLA-DOB, HLA-DRB4, ITGAM
269.9ITGA4, ITGAM, ITGB3, ITGA2B, VTN
27
Hide members
9.9ITGA4, ITGAM, ITGB3, ITGA2B, VTN
28
Hide members
9.9ITGA4, ITGAM, ITGB3, ITGA2B, VTN
299.9HLA-DRB5, HLA-DOB, HLA-DRB4, ITGAM, ITGB3
30
Hide members
9.9ICAM2, ITGA4, ITGB3, ITGA2B, VTN
319.9HLA-DRB5, HLA-DRB4, ITGA4, ITGAM, ITGB3, ITGA2B
32
Hide members
9.8HLA-DRB5, HLA-DOB, HLA-DRB4, ITGA4, ITGAM, CD40LG
33
Hide members
9.8ICAM2, ITGA4, ITGAM, ITGB3, ITGA2B, VTN
34
Hide members
9.8HLA-DRB5, HLA-DOB, HLA-DRB4, ITGA4, B2M, CD40LG
35
Hide members
9.7HLA-DRB5, HLA-DOB, HLA-DRB4, ITGA4, ITGAM, ITGB3
36
Hide members
9.7HLA-DRB5, HLA-DOB, HLA-DRB4, ITGA4, ITGAM, ITGB3
379.7CD40LG, ICAM2, HLA-DRB5, HLA-DOB, HLA-DRB4, ITGA4
38
Hide members
9.6ICAM2, HLA-DRB5, HLA-DOB, HLA-DRB4, ITGA4, ITGAM

Compounds for genes affiliated with Hemorrhagic Fever with Renal Syndrome

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Sources:
59Tocris Bioscience, 44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 2BitterDB
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Compounds related to Hemorrhagic Fever with Renal Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 61)
idCompoundScoreTop Affiliating Genes
1a 2869825910.6ITGA2B, ITGB3, ITGA4
2obtustatin5910.6ITGA2B, ITGB3, ITGA4
3bio 12115910.6ITGA4, ITGB3, ITGA2B
4tc-i 155910.6ITGA2B, ITGB3, ITGA4
5leukadherin 15910.6ITGA2B, ITGB3, ITGA4
6rhodostomin4410.6ITGB3, VTN
7lamivudine44 1111.6B2M, SLPI
8hemophan4410.6ITGAM, B2M
9an 694410.6ITGAM, B2M, VTN
10polyacrylonitrile4410.6VTN, B2M, ITGAM
11pmma4410.6B2M, CD40LG, VTN
12iopentol4410.6SLPI, B2M
13cuprophan4410.5VTN, B2M, ITGAM
14tirofiban44 1111.5ITGB3, ITGA2B, CD40LG, VTN
15abciximab44 1111.5VTN, CD40LG, ITGA2B, ITGB3
16sevoflurane44 1111.5SLPI, GPT, B2M
17silicone4410.5CD40LG, RNPC3, VTN
18titanium4410.5ITGB3, SLPI, VTN
19rgd peptide4410.5VTN, ITGA4
20tobramycin4410.4B2M, RNPC3
21phosphorus4410.4SLPI, GPT, B2M
22formaldehyde44 2411.4ITGAM, ITGA2B, B2M, CD40LG
23ivig4410.4GPT, CD40LG, ITGA4
24urea44 11 2412.4VTN, SLPI, GPT, B2M
25aspartate4410.4VTN, GPT, CD40LG, B2M, ITGA4
26hyaluronic acid44 2411.3B2M, CD40LG, GPT, SLPI, VTN
27polysaccharide4410.3ICAM2, ITGAM, B2M, CD40LG, VTN
28aspirin44 49 28 2413.3ITGAM, ITGB3, CD40LG, VTN
29vitamin d4410.3SLPI, GPT, B2M, ITGB3, ITGAM
30rantes4410.3ICAM2, ITGA4, ITGAM, CD40LG, SLPI
31vitamin b124410.3GPT, CD40LG, B2M
32creatinine4410.3ITGAM, GPT, SLPI
33genistein44 28 59 2 11 2415.2ITGA4, ITGAM, B2M, CD40LG, SLPI
34lactate4410.2ITGAM, B2M, CD40LG, GPT, SLPI, VTN
35serine4410.2ITGA4, ITGAM, ITGA2B, B2M, RNPC3, VTN
36pge24410.2ITGAM, B2M, CD40LG, SLPI, VTN
37neopterin4410.2GPT, CD40LG, B2M
38slea4410.2CD40LG, ITGA4
39theophylline44 28 11 2413.2CD40LG, B2M, ITGAM
40cyclosporin a44 28 5912.2ITGAM, B2M, CD40LG, RNPC3, GPT, SLPI
41iron44 2411.1ITGB3, B2M, RNPC3, GPT, SLPI
42dexamethasone44 49 28 1113.1ITGA4, ITGAM, CD93, CD40LG, SLPI, VTN
43vegf4410.1ITGAM, ITGB3, B2M, CD40LG, SLPI, VTN
44cysteine4410.1ITGAM, ITGB3, ITGA2B, B2M, CD40LG, SLPI
45fibrinogen4410.1VTN, ITGA4, ITGAM, ITGB3, ITGA2B, CD40LG
46alanine4410.0ITGB3, B2M, CD40LG, GPT, SLPI, VTN
47heparin44 28 11 2413.0ITGA4, ITGAM, CD40LG, SLPI, VTN
48tyrosine449.7ICAM2, ITGA4, ITGAM, ITGB3, RNPC3, FRS3
49calcium44 49 11 2412.6ICAM2, ITGA4, ITGAM, ITGB3, ITGA2B, B2M
50adenylate449.6ITGAM, CD40LG, RNPC3, GPT, GPR182

GO Terms for genes affiliated with Hemorrhagic Fever with Renal Syndrome

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Sources:
16Gene Ontology
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Cellular components related to Hemorrhagic Fever with Renal Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule membraneGO:03109210.3ITGA2B, ITGB3
2MHC class II protein complexGO:04261310.2HLA-DRB4, HLA-DOB, HLA-DRB5
3integrin complexGO:00830510.2ITGA4, ITGAM, ITGB3, ITGA2B
4ER to Golgi transport vesicle membraneGO:01250710.1HLA-DRB5, HLA-DRB4, B2M
5alphav-beta3 integrin-vitronectin complexGO:07106210.0VTN, ITGB3
6external side of plasma membraneGO:0098979.9CD40LG, B2M, ITGA2B, ITGAM, ITGA4, HLA-DRB4
7plasma membraneGO:0058869.1ITGAM, ITGA4, HLA-DRB4, HLA-DRB5, ICAM2, ITGB3

Biological processes related to Hemorrhagic Fever with Renal Syndrome according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1regulation of interleukin-4 productionGO:03267310.5HLA-DRB4, HLA-DRB5
2regulation of interleukin-10 secretionGO:200117910.5HLA-DRB4, HLA-DRB5
3immunoglobulin production involved in immunoglobulin mediated immune responseGO:00238110.5HLA-DRB5, HLA-DRB4
4humoral immune response mediated by circulating immunoglobulinGO:00245510.5HLA-DRB5, HLA-DRB4
5leukocyte cell-cell adhesionGO:00715910.4ITGA4, ITGAM, CD40LG
6T-helper 1 type immune responseGO:04208810.4HLA-DRB4, HLA-DRB5
7interferon-gamma-mediated signaling pathwayGO:06033310.4B2M, HLA-DRB4, HLA-DRB5
8integrin-mediated signaling pathwayGO:00722910.4ITGA2B, ITGB3, ITGAM, ITGA4
9cell-matrix adhesionGO:00716010.4VTN, ITGA2B, ITGB3
10inflammatory response to antigenic stimulusGO:00243710.3HLA-DRB5, HLA-DRB4
11regulation of immune responseGO:05077610.3CD40LG, B2M, ITGA4, ICAM2
12antigen processing and presentation of exogenous peptide antigen via MHC class IIGO:01988610.3HLA-DRB5, HLA-DOB, HLA-DRB4
13detection of bacteriumGO:01604510.3HLA-DRB4, HLA-DRB5
14positive regulation of vascular endothelial growth factor receptor signaling pathwayGO:03094910.3VTN, ITGB3
15positive regulation of insulin secretion involved in cellular response to glucose stimulusGO:03577410.2HLA-DRB4, HLA-DRB5
16leukocyte migrationGO:0509009.9ITGA4, ITGAM, ITGB3

Molecular functions related to Hemorrhagic Fever with Renal Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:03239510.2HLA-DRB4, HLA-DOB

Products for genes affiliated with Hemorrhagic Fever with Renal Syndrome

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Sources for Hemorrhagic Fever with Renal Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet