MCID: HMR004
MIFTS: 53

Hemorrhagic Fever with Renal Syndrome malady

Infectious diseases, Rare diseases, Nephrological diseases categories

Aliases & Classifications for Hemorrhagic Fever with Renal Syndrome

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Sources:
10Disease Ontology, 12DISEASES, 65UMLS, 36MeSH, 51Orphanet, 59SNOMED-CT, 29ICD9CM, 42NCIt, 28ICD10 via Orphanet, 37MESH via Orphanet, 66UMLS via Orphanet
See all sources

Aliases & Descriptions for Hemorrhagic Fever with Renal Syndrome:

Name: Hemorrhagic Fever with Renal Syndrome 10 12 65 36
Hantavirosis 51 65
Hemorrhagic Fever - Renal Syndrome 51
Hemorrhagic Nephrosonephritis 10
 
Hemorrhagic Fever, Russian 10
Puumala Virus Nephropathy 10
Hantavirus Fever 51
Hfrs 10


Classifications:



External Ids:

Disease Ontology10 DOID:11266
ICD9CM29 078.6
MeSH36 D006480
NCIt42 C84753
Orphanet51 340
ICD10 via Orphanet28 A98.5+, N08.0*
MESH via Orphanet37 C535630, D006480
UMLS via Orphanet66 C0019101, C2930957

Summaries for Hemorrhagic Fever with Renal Syndrome

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Disease Ontology:10 A viral infectious disease that is a hemorrhagic fever, located in kidney, has material basis in hantaan virus, has material basis in dobrava-belgrade virus, has material basis in seoul virus, or has material basis in puumala virus, which are carried and transmitted by rodents. the infection has symptom headache, has symptom fever, has symptom muscle pains, has symptom facial flush, has symptom petechiae, has symptom hemorrhagic features, has symptom proteinuria, and has symptom renal failure.

MalaCards based summary: Hemorrhagic Fever with Renal Syndrome, also known as hantavirosis, is related to myocardial infarction and hemorrhagic fever, and has symptoms including abnormality of temperature regulation, renal insufficiency and abnormality of the renal tubule. An important gene associated with Hemorrhagic Fever with Renal Syndrome is CD40LG (CD40 Ligand), and among its related pathways are LDL Oxidation in Atherogenesis and NF-kappa B signaling pathway. Affiliated tissues include kidney, kidney and lung, and related mouse phenotypes are liver/biliary system and renal/urinary system.

Related Diseases for Hemorrhagic Fever with Renal Syndrome

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Diseases related to Hemorrhagic Fever with Renal Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 274)
idRelated DiseaseScoreTop Affiliating Genes
1myocardial infarction29.9CRP, ICAM1, IL6, ITGB3, SERPINC1, TNF
2hemorrhagic fever11.5
3nephropathia epidemica10.7
4hantavirus pulmonary syndrome10.7
5korean hemorrhagic fever10.6
6acute pancreatitis10.5
7pancreatitis10.5
8viral hemorrhagic fever10.5
9hemophagocytic lymphohistiocytosis10.5
10hypopituitarism10.5
11adult syndrome10.4
12familial mediterranean fever, ar10.4
13child syndrome10.4
14good syndrome10.4
15acalculous cholecystitis10.4
16renal infectious disease10.4
17cholecystitis10.4
18viral infectious disease10.4
19kid syndrome10.4
20wells syndrome10.4
21endotheliitis10.4
22acute myocarditis10.3CD40LG, CRP
23cold urticaria10.3CRP, IL6
24recurrent corneal erosion10.3CD40LG, CRP
25cryptomicrotia brachydactyly syndrome10.3CRP, IL6
26spondylocamptodactyly10.3B2M, TNF
27acute allergic sanguinous otitis media10.3B2M, IL6
28mononeuritis of lower limb10.3CD40LG, CRP
29larynx squamous papilloma10.3CD40LG, SERPINC1
30post-traumatic stress disorder10.3CD40LG, CRP
31acinic cell breast carcinoma10.3CRP, IL6
32fallopian tube germ cell cancer10.3CD40LG, CRP
33fowler's syndrome10.3CD40LG, SERPINC1
34childhood absence epilepsy10.3CD40LG, TNF
35dural sinus malformation10.3CRP, IL6
36crohn's disease10.3IL6, TNF
37hepatic cystic hamartoma10.3CD40LG, SERPINC1
38aorta atresia10.3IL6, TNF
39plantar nerve lesion10.3IL6, TNF
40salpingo-oophoritis10.3CD40LG, CRP
4146 xx gonadal dysgenesis10.3CD40LG, TNF
42protozoal dysentery10.3CD40LG, IL6
43malignant sertoli-leydig cell tumor of ovary10.3IL6, TNF
44vascular skin disease10.3B2M, CD40LG
45penis sarcoma10.3CD40LG, CRP
46malignant cornea melanoma10.3B2M, CRP
47larynx sarcoma10.3IL6, TNF
48glycogen storage disease viii10.2IL6, TNF
49pyelonephritis10.2B2M, CD40LG, CRP
50chronic gonorrhea of cervix10.2CRP, TNF

Graphical network of the top 20 diseases related to Hemorrhagic Fever with Renal Syndrome:



Diseases related to hemorrhagic fever with renal syndrome

Symptoms for Hemorrhagic Fever with Renal Syndrome

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Symptoms:

 51 10 (show all 39)
  • fever/chilling
  • asthenia/fatigue/weakness
  • chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis
  • conjunctival injection/chemosis/red eye
  • photophobia
  • acute abdominal pain/colic
  • abnormal hepatic enzymes/transaminases
  • abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
  • lung/pulmonary infiltrates
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • atelectasia/pulmonary collapse
  • renal tubular defect/tubulopathy
  • interstitial nephropathy
  • renal failure
  • proteinuria
  • pollakiuria/polyuria/dysuria/anuria/acute urine retention/oliguria
  • facial pain/cephalalgia/migraine
  • myalgia/muscular pain
  • articular/joint pain/arthralgia
  • hyperleukocytosis/leukocytosis
  • thrombocytopenia/thrombopenia
  • hypoproteinemia
  • transient amaurosis/acute visual trouble
  • myopia
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • hemoptysis
  • myocardium anomalies/myocarditis
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
  • cardiac rhythm disorder/arrhythmia
  • chronic arterial hypertension
  • hypotension
  • intracranial/cerebral/meningeal hemorrhage
  • early death/lethality
  • headache
  • fever
  • muscle pains
  • facial flush
  • petechiae
  • hemorrhagic features

HPO human phenotypes related to Hemorrhagic Fever with Renal Syndrome:

(show all 28)
id Description Frequency HPO Source Accession
1 abnormality of temperature regulation hallmark (90%) HP:0004370
2 renal insufficiency typical (50%) HP:0000083
3 abnormality of the renal tubule typical (50%) HP:0000091
4 proteinuria typical (50%) HP:0000093
5 conjunctivitis typical (50%) HP:0000509
6 photophobia typical (50%) HP:0000613
7 thrombocytopenia typical (50%) HP:0001873
8 leukocytosis typical (50%) HP:0001974
9 abdominal pain typical (50%) HP:0002027
10 migraine typical (50%) HP:0002076
11 respiratory insufficiency typical (50%) HP:0002093
12 abnormality of the pleura typical (50%) HP:0002103
13 pulmonary infiltrates typical (50%) HP:0002113
14 arthralgia typical (50%) HP:0002829
15 elevated hepatic transaminases typical (50%) HP:0002910
16 hypoproteinemia typical (50%) HP:0003075
17 myalgia typical (50%) HP:0003326
18 atelectasis typical (50%) HP:0100750
19 myopia occasional (7.5%) HP:0000545
20 hypertension occasional (7.5%) HP:0000822
21 abnormality of the myocardium occasional (7.5%) HP:0001637
22 abnormality of the pericardium occasional (7.5%) HP:0001697
23 hemoptysis occasional (7.5%) HP:0002105
24 intracranial hemorrhage occasional (7.5%) HP:0002170
25 gastrointestinal hemorrhage occasional (7.5%) HP:0002239
26 hypotension occasional (7.5%) HP:0002615
27 arrhythmia occasional (7.5%) HP:0011675
28 amaurosis fugax occasional (7.5%) HP:0100576

Drugs & Therapeutics for Hemorrhagic Fever with Renal Syndrome

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Drugs for Hemorrhagic Fever with Renal Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
EpinephrineapprovedPhase 2, Phase 176851-43-45816
Synonyms:
(-)-(R)-Epinephrine
(-)-3,4-Dihydroxy-a-[2-(methylamino)ethyl]benzyl alcohol
(-)-3,4-Dihydroxy-alpha-((methylamino)methyl)benzyl alcohol
(-)-3,4-Dihydroxy-alpha-[2-(methylamino)ethyl]benzyl alcohol
(-)-3,4-dihydroxy-a-[(methylamino)methyl]-Benzyl alcohol
(-)-3,4-dihydroxy-alpha-[(methylamino)methyl]-Benzyl alcohol
(-)-Adrenalin
(-)-Adrenaline
(-)-Epinephrine
(-)-R-Epinephrine
(R)-(-)-Adnephrine
(R)-(-)-Adrenaline
(R)-(-)-Epinephrine
(R)-(-)-Epirenamine
(R)-(−)-adrenaline
(R)-4-[1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
(R)-4-[1-hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol
(R)-Adrenaline
(R)-Epinephrine
(−)-adrenaline
02252_FLUKA
1-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
1-Adrenalin
1-Epinephrine
4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-benzenediol
4-(1-hydroxy-2-methylamino-ethyl)benzene-1,2-diol
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol
51-43-4
51-43-4 (FREE BASE)
51028-73-0
A0173
AC-13188
AC1L1L7B
ADR ADRENALINE
ADROP
AI3-19015
Adnephrine
Adrenaclick
Adrenal
Adrenalin
Adrenalin (TN)
Adrenalin in Oil
Adrenalin-Medihaler
Adrenalina
Adrenalina [DCIT]
Adrenaline
Adrenaline (JP15)
Adrenaline/Epinephrine
Adrenalinum
Adrenamine
Adrenan
Adrenapax
Adrenasol
Adrenatrate
Adrenine
Adrenodis
Adrenohorma
Adrenosan
Adrenutol
Adrin
Adrine
Ana-Guard
Ana-Kit
Antiasthmatique
Asmatane Mist
Asthma meter mist
Asthma-nefrin
Asthmahaler Mist
Asthmanefrin
Astmahalin
Astminhal
Auvi-q
BIDD:GT0119
Balmadren
Bernarenin
Biorenine
Bosmin
Brevirenin
Bronkaid
Bronkaid Mist
Bronkaid Suspension Mist
Bupivacaine Hcl and Epinephrine
C00788
CCRIS 4812
CHEBI:28918
CHEMBL679
CID5816
Chelafrin
Citanest Forte
Corisol
D-Epifrin
D-Epinephrine
D00095
DB00668
Drenamist
Dylephrin
Dyspne-Inhal
E4250_SIGMA
EINECS 200-098-7
EPI E Z PEN JR
EPIPEN E Z PEN
EPIPEN JR
Epi EZ Pen Jr
Epifrin
Epiglaufrin
Epinefrin
Epinefrin [Czech]
Epinefrina
Epinefrina [INN-Spanish]
Epinephran
Epinephrin
Epinephrine
Epinephrine (USP)
Epinephrine (USP/INN)
Epinephrine [USAN:INN:JAN]
Epinephrine bitartrate
Epinephrine chloride
Epinephrine hydrochloride
Epinephrinum
Epinephrinum [INN-Latin]
Epipen
Epipen (TN)
Epipen Auto-Injector
Epipen EZ Pen
Epipen Jr
Epipen Jr.
Epipen Jr. Auto-Injector
Epipen jr
Epirenamine
Epirenan
Epirenin
Epitrate
Eppy
 
Esphygmogenina
Exadrin
Glaucon
Glaucosan
Glauposine
Glycirenan
HSCI1_000215
HSDB 4289
Haemostasin
Haemostatin
Hektalin
Hemisine
Hemostasin
Hemostatin
Hypernephrin
Hyporenin
IOP
Intranefrin
Iontocaine
Isoptoepinal
Kidoline
L-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
L-Adrenaline
L-Adrenaline Base
L-Epinehphrine
L-Epinephrine
L-Epirenamine
L-Methylaminoethanolcatechol
L-epinephrine
LS-156
Levo-Methylaminoethanolcatechol
Levoadrenaline
Levoepinephrine
Levorenen
Levorenin
Levorenine
Levoreninum
Lopac-E-4642
Lyodrin
Lyophrin
Medihaler-Epi
Metanephrin
Methylaminoethanolcatechol
Methylarterenol
Micronefrin
Micronephrine
MolPort-002-051-368
Mucidrina
Myosthenine
Mytrate
NCGC00015417-01
NCGC00142615-01
NCGC00142615-03
NCGC00142615-04
NCGC00142615-05
NCGC00142615-06
NCGC00142615-07
NSC 62786
NSC62786
Nephridine
Nieraline
PDSP1_001120
PDSP2_001104
Paranephrin
Primatene
Primatene Mist
Primatene Mist Refill
Prime Asthma Relief
R-(-)-Epinephrine
R-Adrenaline
RCRA waste no. P042
Racemic Epinephrine
Racepinephrine
Rcra waste number P042
Renagladin
Renaglandin
Renaglandulin
Renaleptine
Renalina
Renoform
Renostypricin
Renostypticin
Renostyptin
SMP1_000227
ST069368
SUS-PHRINE SULFITE-FREE
Scurenaline
Septocaine
Simplene
Sindrenina
Soladren
Sphygmogenin
Stryptirenal
Styptirenal
Supracapsulin
Supradin
Supranefran
Supranephrane
Supranephrine
Supranol
Suprarenaline
Suprarenin
Suprel
Surenine
Surrenine
Sus-Phrine
Sus-phrine
Susphrine
Sympathin I
Takamina
Takamine
Tokamina
Tonogen
Twinject
Twinject 0.15
Twinject 0.3
Twinject 0.30
UNII-YKH834O4BH
Vaponefrin
Vasoconstrictine
Vasoconstrictor
Vasodrine
Vasoton
Vasotonin
adrenaline
bmse000316
d-Adrenaline
epinephrine
l-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
l-Adrenalin
l-Adrenaline
l-Epinephine
l-Epinephrine (synthetic)
l-Epirenamine
l-Methylaminoethanolcatechol
levoepinephrine
nchembio747-comp9
2
RibavirinapprovedPhase 291436791-04-537542
Synonyms:
1-.beta.-D-Ribofuranosyl-1,2,4-triazolo-3-carboxamide
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazole-3-carboxamide
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-1,2,4-triazole-3-carboxamide
1-beta-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide
1-beta-D-Ribofuranosyl-1H-1,2,4-triazole-3-carboxamide
1-beta-D-ribofuranosyl-1-H-1,2,4-triazole-3-carboxamide
36791-04-5
437710-49-1
66510-90-5
AA-504/07617051
AB00430481
AC1L1XXZ
AC1Q1IDC
AC1Q4ZGS
AKOS001715163
BB_NC-0567
BPBio1_001195
BRN 0892462
BSPBio_001085
BSPBio_003352
C-Virin
CHEMBL1643
CID37542
Copegus
Copegus (TN)
Cotronak
D00423
DB00811
DRG-0028
DivK1c_000782
Drug: Ribavirin
EU-0101063
FT-0082885
HMS2090L15
HMS2094O09
HMS502H04
HSDB 6513
ICN-1229
IDI1_000782
Ibavyr
KBio1_000782
KBio2_002328
KBio2_004896
KBio2_007464
KBio3_002854
KBioGR_001804
KBioSS_002331
KS-1104
LS-1241
Lopac0_001063
MLS000028486
MLS002222317
Moderiba
MolPort-002-507-104
MolPort-002-885-856
NCGC00090726-01
NCGC00090726-03
NCGC00090726-04
NCGC00090726-05
NCGC00090726-06
NCGC00090726-07
NINDS_000782
 
NSC 163039
NSC163039
Prestwick3_000993
R 9644
R-964
R9644_SIGMA
RBV
RG-964
RIBAV
RTC
RTCA
RTP
Ravanex
Rebetol
Rebetol (TN)
Rebetron
Rebretron
Ribacine
Ribamide
Ribamidil
Ribamidyl
Ribasphere
Ribasphere (TN)
Ribasphere Ribapak
Ribav
Ribavirin
Ribavirin (JAN/USP/INN)
Ribavirin Capsules
Ribavirin Triphosphate
Ribavirin [USAN:INN]
Ribavirin-TP
Ribavirina
Ribavirina [INN-Spanish]
Ribavirine
Ribavirine [INN-French]
Ribavirinum
Ribavirinum [INN-Latin]
Ribovirin
Ro 20-9963/000
Ro-20-9963
S2504_Selleck
SCH 18908
SMP1_000261
SMR000058315
SPECTRUM1503938
SR-01000076112-3
Spectrum3_001876
Spectrum4_001252
Spectrum5_002075
Spectrum_001826
Tribavirin
UNII-49717AWG6K
Varazid
Vilona
Viramid
Viramide
Virazid
Virazide
Virazole
Virazole (Ribavirin) Inhalation Solution
Virazole (TN)
Virazole 5'-triphosphate
ZINC01035331
ribavirin
3Epinephryl boratePhase 2, Phase 1768
4RacepinephrinePhase 2, Phase 1768

Interventional clinical trials:

idNameStatusNCT IDPhase
1Study to Evalutate Long-term Immunity of Hantavax in High Risk Population of HFRSCompletedNCT02360514Phase 3
2Phase 2a Immunogenicity Study of Hantaan/Puumala Virus DNA Vaccine for Prevention of Hemorrhagic FeverRecruitingNCT02116205Phase 2
3Ribavirin for Hemorrhagic Fever With Renal SyndromeEnrolling by invitationNCT00623168Phase 2
4Ribavirin for Hemorrhagic Fever With Renal Syndrome in GermanyEnrolling by invitationNCT00868946Phase 2
5Palifermin in Preventing Oral Mucositis Caused by Chemotherapy and/or Radiation Therapy in Young Patients Undergoing Stem Cell TransplantWithdrawnNCT00728585Phase 2
6Study to Evaluate the Safety, Tolerability, and Immunogenicity of Hantaan and Puumala Virus DNA VaccinesCompletedNCT01502345Phase 1
7Diagnostic of Puumala Virus Infection in FranceRecruitingNCT02455375
8West Indies-French Guiana Dengue StudyRecruitingNCT01099852

Search NIH Clinical Center for Hemorrhagic Fever with Renal Syndrome


Cochrane evidence based reviews: Hemorrhagic Fever with Renal Syndrome

Genetic Tests for Hemorrhagic Fever with Renal Syndrome

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Anatomical Context for Hemorrhagic Fever with Renal Syndrome

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MalaCards organs/tissues related to Hemorrhagic Fever with Renal Syndrome:

33
Kidney, Lung, T cells, Eye, Testes, Endothelial, B cells

FMA organs/tissues related to Hemorrhagic Fever with Renal Syndrome:

16
Kidney

Animal Models for Hemorrhagic Fever with Renal Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Hemorrhagic Fever with Renal Syndrome:

38 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.0B2M, IFNG, IL6, ITGB3, SERPINC1, TNF
2MP:00053678.0CD40LG, IFNG, IL6, ITGB3, SEMA4D, SERPINC1
3MP:00053817.9B2M, ICAM1, IFNG, IL6, ITGB3, TNF
4MP:00053917.7ICAM1, IFNG, IL6, ITGB3, SERPINC1, TNF
5MP:00020067.7B2M, ICAM1, IFNG, IL6, ITGB3, TNF
6MP:00107717.5B2M, CD40LG, ICAM1, IFNG, IL6, ITGB3
7MP:00036317.4B2M, CD40LG, ICAM1, IFNG, IL6, SEMA4D
8MP:00053856.6B2M, CD40LG, CRP, ICAM1, IFNG, IL6
9MP:00053976.2B2M, CD40LG, ICAM1, IFNG, IL6, ITGB3
10MP:00053766.2B2M, CD40LG, CRP, ICAM1, IFNG, IL6
11MP:00053876.0B2M, CD40LG, CRP, ICAM1, IFNG, IL6

Publications for Hemorrhagic Fever with Renal Syndrome

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Articles related to Hemorrhagic Fever with Renal Syndrome:

(show top 50)    (show all 346)
idTitleAuthorsYear
1
Correction: Spatiotemporal Transmission Dynamics of Hemorrhagic Fever with Renal Syndrome in China, 2005-2012. (25799067)
2015
2
Acalculous cholecystitis associated with hemorrhagic fever with renal syndrome: a case report. (25982259)
2015
3
Community Acquired Severe Acute Kidney Injury Caused by Hantavirus-Induced Hemorrhagic Fever with Renal Syndrome Has a Favorable Outcome. (26139246)
2015
4
Increased risk for lymphoma following hemorrhagic fever with renal syndrome. (24965350)
2014
5
Ecology and geography of hemorrhagic fever with renal syndrome in Changsha, China. (23819824)
2013
6
Hemorrhagic fever with renal syndrome and Crimean-Congo hemorrhagic fever as causes of acute undifferentiated febrile illness in Bulgaria. (23421884)
2013
7
A case of ruptured renal cortical arteriovenous malformation of the right testicular vein in hemorrhagic fever with renal syndrome. (23682233)
2013
8
A retrospective study of acute pancreatitis in patients with hemorrhagic fever with renal syndrome. (24345089)
2013
9
Serum TNF-I+, sTNFR1, IL-6, IL-8 and IL-10 levels in hemorrhagic fever with renal syndrome. (23603136)
2013
10
Correction: Investigating the Effects of Food Available and Climatic Variables on the Animal Host Density of Hemorrhagic Fever with Renal Syndrome in Changsha, China. (24058426)
2013
11
Hantavirus infection--hemorrhagic fever with renal syndrome: the first case series reported in Romania and review of the literature. (21678038)
2012
12
Experience with extrarenal manifestations of hemorrhagic fever with renal syndrome in a tertiary care hospital in South Korea. (21292889)
2011
13
Collective immunity of the population from endemic zones of hemorrhagic fever with renal syndrome in Kosovo. (20088164)
2009
14
Renal artery embolization of perirenal hematoma in hemorrhagic fever with renal syndrome: a case report. (17673847)
2007
15
Dynamic changes of apoptosis-inducing ligands and Th1/Th2 like subpopulations in Hantaan virus-induced hemorrhagic fever with renal syndrome. (16616877)
2006
16
Comparison of virulence of various hantaviruses related to hemorrhagic fever with renal syndrome in newborn mouse model. (15070039)
2004
17
Hemorrhagic fever with renal syndrome: imported or native disease in the Zadar region]. (15011474)
2003
18
Hemorrhagic fever with renal syndrome presenting with intrauterine fetal death. A case report. (12971153)
2003
19
Serological analysis of hemorrhagic fever with renal syndrome (HFRS) patients in Far Eastern Russia and identification of the causative hantavirus genotype. (12898330)
2003
20
Hemorrhagic fever with renal syndrome: diagnostic problems with a known disease. (11526193)
2001
21
A case of torsade de pointes associated with hypopituitarism due to hemorrhagic fever with renal syndrome. (11410700)
2001
22
Epidemiological progresses of hemorrhagic fever with renal syndrome in China. (11593522)
1999
23
Direct genetic detection of Dobrava virus in Greek and Albanian patients with hemorrhagic fever with renal syndrome. (8699076)
1996
24
Genetic identification of a new Puumala virus strain causing severe hemorrhagic fever with renal syndrome in Germany. (7995985)
1994
25
Virus-related acute renal failure: the clinical course and outcome of hemorrhagic fever with renal syndrome. (7914707)
1994
26
Elevated levels of total and Puumala virus-specific immunoglobulin E in the Scandinavian type of hemorrhagic fever with renal syndrome. (7496961)
1994
27
Epidemiologic surveillance on the hemorrhagic fever with renal syndrome in China. (7908258)
1993
28
Comparison of European isolates of viruses causing hemorrhagic fever with renal syndrome by a neutralization test. (1684888)
1991
29
Effect of glucocorticoid hormones on the status of the hypothalamo-hypophyseal-adrenal system and endocrine function of the pancreas in patients with hemorrhagic fever with renal syndrome]. (1977953)
1990
30
Hemorrhagic fever with renal syndrome: MR imaging of the kidney. (1971450)
1990
31
Outbreak of hemorrhagic fever with renal syndrome among U.S. Marines in Korea. (1973603)
1990
32
Hemorrhagic fever with renal syndrome. (2647265)
1989
33
What is new and where are the problems in research on hemorrhagic fever with renal syndrome? (2573193)
1989
34
A clinical study of hemorrhagic fever with renal syndrome caused by Seoul virus infection. (2577257)
1989
35
Hemorrhagic fever with renal syndrome. (2573914)
1989
36
Hemorrhagic fever with renal syndrome in Korea. (2568676)
1989
37
Role of maternal antibody in protection from hemorrhagic fever with renal syndrome virus infection in rats. (2905596)
1988
38
Antibody to hemorrhagic fever with renal syndrome viruses (Hantaviruses) in the United States. (2891295)
1987
39
Cats--source of protection or infection? A case-control study of hemorrhagic fever with renal syndrome. (2889355)
1987
40
Hemorrhagic fever with renal syndrome--a clinical perspective. (2867491)
1985
41
Isolation of a virus related to hemorrhagic fever with renal syndrome from urban rats in a nonendemic area. (6143783)
1984
42
Antigenic differences between two viruses, isolated in Japan and Korea, that cause hemorrhagic fever with renal syndrome. (6207309)
1984
43
Features of circulation of hemorrhagic fever with renal syndrome (HFRS) virus among small mammals in the European U.S.S.R. (6220688)
1983
44
Isolation of hemorrhagic fever with renal syndrome (HFRS) virus from a tumor specimen in a rat. (6146307)
1983
45
A preliminary report on hemorrhagic fever with renal syndrome in China. (6137329)
1983
46
Detection of antibody against hemorrhagic fever with renal syndrome (HFRS) virus in sera of house rats captured in port areas of Japan. (6408289)
1983
47
Hemorrhagic fever with renal syndrome (HFRS). (6134332)
1982
48
Hemorrhagic fever with renal syndrome in Finland: ecology and virology of nephropathia epidemica. (6134333)
1982
49
Seroepidemiologic study of epidemic hemorrhagic fever with renal syndrome in China. (6114815)
1981
50
GEOGRAPHICAL DISTRIBUTION OF HEMORRHAGIC FEVER WITH RENAL SYNDROME. (14196952)
1964

Variations for Hemorrhagic Fever with Renal Syndrome

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Expression for genes affiliated with Hemorrhagic Fever with Renal Syndrome

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Search GEO for disease gene expression data for Hemorrhagic Fever with Renal Syndrome.

Pathways for genes affiliated with Hemorrhagic Fever with Renal Syndrome

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Pathways related to Hemorrhagic Fever with Renal Syndrome according to GeneCards Suite gene sharing:

(show all 38)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6ICAM1, TNF
29.4CD40LG, ICAM1, TNF
39.3ICAM1, IL6, TNF
4
Show member pathways
9.3CD40LG, IFNG, TNF
5
Show member pathways
9.2IFNG, IL6, TNF
69.2IFNG, IL6, TNF
79.2IFNG, IL6, TNF
8
Show member pathways
9.2B2M, IFNG, TNF
99.2CD40LG, IFNG, VTN
109.2IFNG, IL6, VTN
11
TNF Signaling (sino)
Show member pathways
9.1IFNG, IL6, VTN
129.0ICAM1, IFNG, IL6
13
Show member pathways
9.0B2M, HLA-DRB1, IFNG
14
B cell receptor signaling pathway (KEGG)
Show member pathways
9.0B2M, HLA-DRB1, IFNG
159.0B2M, CD40LG, IFNG, TNF
169.0HLA-DRB1, HLA-DRB5, ICAM1
179.0ICAM1, IL6, TNF, VTN
188.8ICAM1, ITGB3, VTN
198.7HLA-DRB1, IFNG, IL6, TNF
208.7ICAM1, IFNG, IL6, TNF
218.7ICAM1, IFNG, IL6, TNF
228.7ICAM1, IFNG, IL6, TNF
238.7CD40LG, HLA-DRB1, HLA-DRB5, ICAM1
248.7IFNG, ITGB3, TNF
258.7IL6, ITGB3, TNF, VTN
268.5CD40LG, ICAM1, IFNG, IL6, TNF
27
Show member pathways
8.5CRP, ICAM1, IFNG, IL6, TNF
288.4HLA-DRB1, HLA-DRB5, ICAM1, IL6, TNF
298.4HLA-DRB1, HLA-DRB5, ICAM1, IFNG
30
Show member pathways
8.3CD40LG, HLA-DRB1, HLA-DRB5, IFNG, TNF
318.3HLA-DRB1, HLA-DRB5, IFNG, IL6, TNF
328.1HLA-DRB1, HLA-DRB5, IL6, ITGB3, TNF
33
Show member pathways
8.1B2M, HLA-DRB1, HLA-DRB5, ICAM1, IFNG
34
Show member pathways
8.0B2M, CD40LG, HLA-DRB1, HLA-DRB5, IFNG, TNF
35
Show member pathways
7.7HLA-DRB1, HLA-DRB5, ICAM1, IFNG, IL6, TNF
367.7HLA-DRB1, HLA-DRB5, ICAM1, IFNG, IL6, TNF
37
Show member pathways
7.2B2M, CD40LG, HLA-DRB1, HLA-DRB5, ICAM1, IFNG
38
Show member pathways
5.7B2M, CD40LG, CRP, HLA-DRB1, HLA-DRB5, ICAM1

GO Terms for genes affiliated with Hemorrhagic Fever with Renal Syndrome

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Cellular components related to Hemorrhagic Fever with Renal Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:004261310.1HLA-DRB1, HLA-DRB5
2alphav-beta3 integrin-vitronectin complexGO:007106210.1ITGB3, VTN
3ER to Golgi transport vesicle membraneGO:00125079.8B2M, HLA-DRB1, HLA-DRB5
4extracellular regionGO:00055767.8B2M, CRP, IFNG, IL6, SERPINC1, TNF
5external side of plasma membraneGO:00098977.7B2M, CD40LG, HLA-DRB1, HLA-DRB5, ICAM1, IFNG
6extracellular exosomeGO:00700626.8B2M, CRP, HLA-DRB1, HLA-DRB5, ICAM1, ITGB3
7plasma membraneGO:00058866.5B2M, CD40LG, HLA-DRB1, HLA-DRB5, ICAM1, ITGB3
8extracellular spaceGO:00056156.0B2M, CD40LG, CRP, HLA-DRB5, ICAM1, IFNG

Biological processes related to Hemorrhagic Fever with Renal Syndrome according to GeneCards Suite gene sharing:

(show all 40)
idNameGO IDScoreTop Affiliating Genes
1epithelial cell proliferation involved in salivary gland morphogenesisGO:006066410.6IL6, TNF
2positive regulation of chemokine productionGO:003272210.5IL6, TNF
3regulation of immunoglobulin secretionGO:005102310.5CD40LG, TNF
4negative regulation of alkaline phosphatase activityGO:001069310.5SEMA4D, TNF
5positive regulation of receptor-mediated endocytosisGO:004826010.4B2M, VTN
6neutrophil apoptotic processGO:000178110.3IFNG, IL6
7positive regulation of vitamin D biosynthetic processGO:006055710.3IFNG, TNF
8regulation of interleukin-10 secretionGO:200117910.3HLA-DRB1, HLA-DRB5
9cell adhesion mediated by integrinGO:003362710.3ICAM1, VTN
10positive regulation of calcidiol 1-monooxygenase activityGO:006055910.2IFNG, TNF
11regulation of interleukin-4 productionGO:003267310.2HLA-DRB1, HLA-DRB5
12positive regulation of chemokine biosynthetic processGO:004508010.2IFNG, TNF
13positive regulation of membrane protein ectodomain proteolysisGO:005104410.2IFNG, TNF
14immunoglobulin production involved in immunoglobulin mediated immune responseGO:000238110.2HLA-DRB1, HLA-DRB5
15detection of bacteriumGO:001604510.2HLA-DRB1, HLA-DRB5
16T-helper 1 type immune responseGO:004208810.1HLA-DRB1, HLA-DRB5
17defense response to protozoanGO:004283210.1IFNG, IL6
18humoral immune response mediated by circulating immunoglobulinGO:000245510.1HLA-DRB1, HLA-DRB5
19negative regulation of macrophage derived foam cell differentiationGO:001074510.1CRP, ITGB3
20negative regulation of growth of symbiont in hostGO:004413010.0IFNG, TNF
21positive regulation of vascular endothelial growth factor receptor signaling pathwayGO:00309499.9ITGB3, VTN
22positive regulation of NF-kappaB transcription factor activityGO:00510929.8ICAM1, IL6, TNF
23humoral immune responseGO:00069599.8IFNG, IL6, TNF
24inflammatory responseGO:00069549.7CD40LG, CRP, IL6, TNF
25regulation of cell shapeGO:00083609.7ICAM1, IL6, SEMA4D
26defense response to Gram-positive bacteriumGO:00508309.7B2M, CRP, IL6, TNF
27negative regulation of lipid storageGO:00108889.5CRP, IL6, ITGB3, TNF
28antigen processing and presentationGO:00198829.4HLA-DRB1, HLA-DRB5, IFNG
29leukocyte migrationGO:00509009.2ICAM1, ITGB3, TNF
30positive regulation of gene expressionGO:00106289.2CRP, IFNG, IL6, TNF
31viral entry into host cellGO:00467189.1HLA-DRB1, ICAM1, ITGB3
32positive regulation of nitric oxide biosynthetic processGO:00454299.0ICAM1, IFNG, IL6, TNF
33response to drugGO:00424938.9B2M, ICAM1, IFNG, IL6
34cellular response to lipopolysaccharideGO:00712228.8B2M, ICAM1, IFNG, IL6, TNF
35regulation of immune responseGO:00507768.7B2M, CD40LG, ICAM1, IFNG
36interferon-gamma-mediated signaling pathwayGO:00603338.7B2M, HLA-DRB1, HLA-DRB5, ICAM1, IFNG
37positive regulation of peptidyl-tyrosine phosphorylationGO:00507318.6ICAM1, IL6, ITGB3, SEMA4D, VTN
38extracellular matrix organizationGO:00301988.4ICAM1, ITGB3, TNF, VTN
39cytokine-mediated signaling pathwayGO:00192218.0B2M, HLA-DRB1, HLA-DRB5, ICAM1, IFNG, IL6
40immune responseGO:00069557.4B2M, CD40LG, HLA-DRB1, HLA-DRB5, IFNG, IL6

Molecular functions related to Hemorrhagic Fever with Renal Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:00020209.2ITGB3, SERPINC1, TNF
2cytokine activityGO:00051258.7CD40LG, IFNG, IL6, TNF
3virus receptor activityGO:00016188.6HLA-DRB1, ICAM1, ITGB3

Sources for Hemorrhagic Fever with Renal Syndrome

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet