Hemorrhagic Fever with Renal Syndrome disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Aliases & Classifications for Hemorrhagic Fever with Renal Syndrome

Sources:
¹⁰Disease Ontology, ¹²DISEASES, ³⁶MeSH, ⁶⁵UMLS, ⁵¹Orphanet, ²⁷ICD10, ²⁹ICD9CM, ⁴²NCIt, ⁵⁹SNOMED-CT, ²⁸ICD10 via Orphanet, ³⁷MESH via Orphanet, ⁶⁶UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Hemorrhagic Fever with Renal Syndrome:

Name: Hemorrhagic Fever with Renal Syndrome ¹⁰ ¹² ³⁶ ⁶⁵

Hantavirosis ⁵¹ ⁶⁵

Hemorrhagic Fever-Renal Syndrome ⁵¹

Hemorrhagic Nephrosonephritis ¹⁰

Hemorrhagic Fever, Russian ¹⁰

Puumala Virus Nephropathy ¹⁰

Hantavirus Fever ⁵¹

Hfrs ¹⁰

Classifications:

MalaCards categories:
Global: Infectious diseases, Rare diseases
Anatomical: Skin diseases, Nephrological diseases

See all MalaCards categories (disease lists)

ICD10: ²⁸ ²⁷

Certain infectious and parasitic diseases

Arthropod-borne viral fevers and viral haemorrhagic fevers

Other viral haemorrhagic fevers, not elsewhere classified

Haemorrhagic fever with renal syndrome

Orphanet: ⁵¹

Rare infectious diseases

External Ids:

Disease Ontology¹⁰ DOID:11266

ICD10²⁷ A98.5

ICD9CM²⁹ 078.6

MeSH³⁶ D006480

NCIt⁴² C84753

SNOMED-CT⁵⁹ 102455002, 186701001, 364756009 70826003, more

Orphanet⁵¹ 340

ICD10 via Orphanet²⁸ A98.5+, N08.0*

MESH via Orphanet³⁷ C535630, D006480

UMLS via Orphanet⁶⁶ C0019101, C2930957

UMLS⁶⁵ C0019101, C2930957

Summaries for Hemorrhagic Fever with Renal Syndrome

Sources:
¹⁰Disease Ontology, ³³MalaCards
See all MalaCards sources

Disease Ontology:¹⁰ A viral infectious disease that is a hemorrhagic fever, located in kidney, has material basis in Hantaan virus, has material basis in Dobrava-Belgrade virus, has material basis in Seoul virus, or has material basis in Puumala virus, which are carried and transmitted by rodents. The infection has symptom headache, has symptom fever, has symptom muscle pains, has symptom facial flush, has symptom petechiae, has symptom hemorrhagic features, has symptom proteinuria, and has symptom renal failure.

MalaCards based summary: Hemorrhagic Fever with Renal Syndrome, also known as hantavirosis, is related to myocardial infarction and korean hemorrhagic fever, and has symptoms including abnormality of temperature regulation, renal insufficiency and abnormality of the renal tubule. An important gene associated with Hemorrhagic Fever with Renal Syndrome is CD40LG (CD40 Ligand), and among its related pathways are LDL Oxidation in Atherogenesis and Dendritic Cells Developmental Lineage Pathway. Affiliated tissues include kidney, lung and kidney, and related mouse phenotypes are cardiovascular system and hematopoietic system.

Related Diseases for Hemorrhagic Fever with Renal Syndrome

Sources:
²⁰GeneCards, ¹⁹GeneAnalytics
See all MalaCards sources

Diseases related to Hemorrhagic Fever with Renal Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 234)

id	Related Disease	Score	Top Affiliating Genes
1	myocardial infarction	28.8	CD40LG, CRP, IL6, ITGB3, SERPINC1
2	korean hemorrhagic fever	11.7
3	hemorrhagic fever	11.1
4	nephropathia epidemica	10.8
5	sugarman brachydactyly	10.7	IL6, ITGB3
6	cold urticaria	10.7	CRP, IL6
7	diabetic ketoacidosis	10.7	CD40LG, CRP
8	plasmacytoma	10.7	B2M, IL6
9	neuritis	10.7	CD40LG, CRP
10	hantavirus pulmonary syndrome	10.7
11	intracranial embolism	10.7	CD40LG, CRP
12	erdheim-chester disease	10.7	CD40LG, TNF
13	fallopian tube carcinoma	10.7	CD40LG, CRP
14	catamenial pneumothorax	10.7	CRP, IL6
15	maxillary sinusitis	10.7	CD40LG, CRP
16	anotia	10.7	CRP, IL6
17	indolent myeloma	10.7	B2M, CD40LG
18	peripheral nervous system disease	10.7	CD40LG, CRP
19	multicentric osteolysis nephropathy	10.7	CRP, IL6
20	malignant otitis externa	10.7	CD40LG, CRP
21	sjogren's syndrome	10.7	CD40LG, TNF
22	plasma protein metabolism disease	10.7	CD40LG, IL6
23	acute allergic mucoid otitis media	10.7	B2M, CRP
24	rumination disorder	10.6	CD40LG, CRP
25	stomach cancer	10.6	CRP, IL6
26	aids dysmorphic syndrome	10.6	B2M, TNF
27	plantar nerve lesion	10.6	IL6, TNF
28	intermediate dend syndrome	10.6	IL6, TNF
29	crohn's disease	10.6	IL6, TNF
30	malignant sertoli-leydig cell tumor of ovary	10.6	IL6, TNF
31	brucella melitensis brucellosis	10.6	CD40LG, TNF
32	subacute glomerulonephritis	10.6	B2M, CD40LG
33	mammary paget's disease	10.6	IL6, TNF
34	herpes gestationis	10.6	CD40LG, VTN
35	wrinkles	10.6	CD40LG, IL6
36	portal hypertension	10.5	B2M, CD40LG
37	keratoderma hereditarium mutilans with ichthyosis	10.5	CD40LG, CRP
38	overnutrition	10.5	B2M, CD40LG, IL6
39	supine hypotensive syndrome	10.5	B2M, CD40LG, IL6
40	rowley-rosenberg syndrome	10.5	CD163, CRP
41	endocarditis	10.5	B2M, CRP, IL6
42	posterior valve urethra	10.5	IL6, TNF
43	cell type benign neoplasm	10.5	B2M, CD40LG, IL6
44	intestinal impaction	10.5	CD40LG, CRP, IL6
45	t cell immunodeficiency primary	10.5	IL6, TNF
46	macrophagic myofasciitis	10.5	CD163, TNF
47	chronic lymphocytic leukemia	10.5	B2M, CRP, IL6
48	colon sarcoma	10.5	B2M, CD40LG, TNF
49	residual stage angle-closure glaucoma	10.5	IL6, TNF
50	parovarian cyst	10.5	IL6, TNF

Graphical network of the top 20 diseases related to Hemorrhagic Fever with Renal Syndrome:

Symptoms for Hemorrhagic Fever with Renal Syndrome

Sources:
⁶¹The Human Phenotype Ontology, ⁵¹Orphanet, ¹⁰Disease Ontology
See all MalaCards sources

Symptoms:

⁵¹ ¹⁰ (show all 39)

fever/chilling
asthenia/fatigue/weakness
chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis
conjunctival injection/chemosis/red eye
photophobia
acute abdominal pain/colic
abnormal hepatic enzymes/transaminases
abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
lung/pulmonary infiltrates
respiratory distress/dyspnea/respiratory failure/lung volume reduction
atelectasia/pulmonary collapse
renal tubular defect/tubulopathy
interstitial nephropathy
renal failure
proteinuria
pollakiuria/polyuria/dysuria/anuria/acute urine retention/oliguria
facial pain/cephalalgia/migraine
myalgia/muscular pain
articular/joint pain/arthralgia
hyperleukocytosis/leukocytosis

thrombocytopenia/thrombopenia
hypoproteinemia
transient amaurosis/acute visual trouble
myopia
gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
hemoptysis
myocardium anomalies/myocarditis
pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
cardiac rhythm disorder/arrhythmia
chronic arterial hypertension
hypotension
intracranial/cerebral/meningeal hemorrhage
early death/lethality
headache
fever
muscle pains
facial flush
petechiae
hemorrhagic features

HPO human phenotypes related to Hemorrhagic Fever with Renal Syndrome:

(show all 28)

id	Description	Frequency	HPO Source Accession
1	abnormality of temperature regulation	hallmark (90%)	HP:0004370
2	renal insufficiency	typical (50%)	HP:0000083
3	abnormality of the renal tubule	typical (50%)	HP:0000091
4	proteinuria	typical (50%)	HP:0000093
5	conjunctivitis	typical (50%)	HP:0000509
6	photophobia	typical (50%)	HP:0000613
7	thrombocytopenia	typical (50%)	HP:0001873
8	leukocytosis	typical (50%)	HP:0001974
9	abdominal pain	typical (50%)	HP:0002027
10	migraine	typical (50%)	HP:0002076
11	respiratory insufficiency	typical (50%)	HP:0002093
12	abnormality of the pleura	typical (50%)	HP:0002103
13	pulmonary infiltrates	typical (50%)	HP:0002113
14	arthralgia	typical (50%)	HP:0002829
15	elevated hepatic transaminases	typical (50%)	HP:0002910
16	hypoproteinemia	typical (50%)	HP:0003075
17	myalgia	typical (50%)	HP:0003326
18	atelectasis	typical (50%)	HP:0100750
19	myopia	occasional (7.5%)	HP:0000545
20	hypertension	occasional (7.5%)	HP:0000822
21	abnormality of the myocardium	occasional (7.5%)	HP:0001637
22	abnormality of the pericardium	occasional (7.5%)	HP:0001697
23	hemoptysis	occasional (7.5%)	HP:0002105
24	intracranial hemorrhage	occasional (7.5%)	HP:0002170
25	gastrointestinal hemorrhage	occasional (7.5%)	HP:0002239
26	hypotension	occasional (7.5%)	HP:0002615
27	arrhythmia	occasional (7.5%)	HP:0011675
28	amaurosis fugax	occasional (7.5%)	HP:0100576

Drugs & Therapeutics for Hemorrhagic Fever with Renal Syndrome

Sources:
⁴⁴NIH Clinical Center, ⁴ClinicalTrials, ⁶Cochrane Library, ¹³DrugBank, ²⁶HMDB, ⁹DGIdb, ⁵³PharmGKB, ³⁰IUPHAR, ⁴⁷Novoseek, ¹BitterDB
See all MalaCards sources

Drugs for Hemorrhagic Fever with Renal Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)

id

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Antibodies

Phase 3

4477

2

Vaccines

Phase 3, Phase 2, Phase 1

6085

3

Immunoglobulins

Phase 3

4477

4

Epinephrine

approved

Phase 2, Phase 1

834

51-43-4

5816

Synonyms:

(-)-(R)-Epinephrine

(-)-3,4-Dihydroxy-a-[2-(methylamino)ethyl]benzyl alcohol

(-)-3,4-Dihydroxy-alpha-((methylamino)methyl)benzyl alcohol

(-)-3,4-Dihydroxy-alpha-[2-(methylamino)ethyl]benzyl alcohol

(-)-3,4-dihydroxy-a-[(methylamino)methyl]-Benzyl alcohol

(-)-3,4-dihydroxy-alpha-[(methylamino)methyl]-Benzyl alcohol

(-)-Adrenalin

(-)-Adrenaline

(-)-Epinephrine

(-)-R-Epinephrine

(R)-(-)-Adnephrine

(R)-(-)-Adrenaline

(R)-(-)-Epinephrine

(R)-(-)-Epirenamine

(R)-(−)-adrenaline

(R)-4-[1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol

(R)-4-[1-hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol

(R)-Adrenaline

(R)-Epinephrine

(−)-adrenaline

02252_FLUKA

1-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol

1-Adrenalin

1-Epinephrine

4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-benzenediol

4-(1-hydroxy-2-methylamino-ethyl)benzene-1,2-diol

4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol

4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol

4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol

51-43-4

51-43-4 (FREE BASE)

51028-73-0

A0173

AC-13188

AC1L1L7B

ADR ADRENALINE

ADROP

AI3-19015

Adnephrine

Adrenaclick

Adrenal

Adrenalin

Adrenalin (TN)

Adrenalin in Oil

Adrenalin-Medihaler

Adrenalina

Adrenalina [DCIT]

Adrenaline

Adrenaline (JP15)

Adrenaline/Epinephrine

Adrenalinum

Adrenamine

Adrenan

Adrenapax

Adrenasol

Adrenatrate

Adrenine

Adrenodis

Adrenohorma

Adrenosan

Adrenutol

Adrin

Adrine

Ana-Guard

Ana-Kit

Antiasthmatique

Asmatane Mist

Asthma meter mist

Asthma-nefrin

Asthmahaler Mist

Asthmanefrin

Astmahalin

Astminhal

Auvi-q

BIDD:GT0119

Balmadren

Bernarenin

Biorenine

Bosmin

Brevirenin

Bronkaid

Bronkaid Mist

Bronkaid Suspension Mist

Bupivacaine Hcl and Epinephrine

C00788

CCRIS 4812

CHEBI:28918

CHEMBL679

CID5816

Chelafrin

Citanest Forte

Corisol

D-Epifrin

D-Epinephrine

D00095

DB00668

Drenamist

Dylephrin

Dyspne-Inhal

E4250_SIGMA

EINECS 200-098-7

EPI E Z PEN JR

EPIPEN E Z PEN

EPIPEN JR

Epi EZ Pen Jr

Epifrin

Epiglaufrin

Epinefrin

Epinefrin [Czech]

Epinefrina

Epinefrina [INN-Spanish]

Epinephran

Epinephrin

Epinephrine

Epinephrine (USP)

Epinephrine (USP/INN)

Epinephrine [USAN:INN:JAN]

Epinephrine bitartrate

Epinephrine chloride

Epinephrine hydrochloride

Epinephrinum

Epinephrinum [INN-Latin]

Epipen

Epipen (TN)

Epipen Auto-Injector

Epipen EZ Pen

Epipen Jr

Epipen Jr.

Epipen Jr. Auto-Injector

Epipen jr

Epirenamine

Epirenan

Epirenin

Epitrate

Eppy

Esphygmogenina

Exadrin

Glaucon

Glaucosan

Glauposine

Glycirenan

HSCI1_000215

HSDB 4289

Haemostasin

Haemostatin

Hektalin

Hemisine

Hemostasin

Hemostatin

Hypernephrin

Hyporenin

IOP

Intranefrin

Iontocaine

Isoptoepinal

Kidoline

L-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol

L-Adrenaline

L-Adrenaline Base

L-Epinehphrine

L-Epinephrine

L-Epirenamine

L-Methylaminoethanolcatechol

L-epinephrine

LS-156

Levo-Methylaminoethanolcatechol

Levoadrenaline

Levoepinephrine

Levorenen

Levorenin

Levorenine

Levoreninum

Lopac-E-4642

Lyodrin

Lyophrin

Medihaler-Epi

Metanephrin

Methylaminoethanolcatechol

Methylarterenol

Micronefrin

Micronephrine

MolPort-002-051-368

Mucidrina

Myosthenine

Mytrate

NCGC00015417-01

NCGC00142615-01

NCGC00142615-03

NCGC00142615-04

NCGC00142615-05

NCGC00142615-06

NCGC00142615-07

NSC 62786

NSC62786

Nephridine

Nieraline

PDSP1_001120

PDSP2_001104

Paranephrin

Primatene

Primatene Mist

Primatene Mist Refill

Prime Asthma Relief

R-(-)-Epinephrine

R-Adrenaline

RCRA waste no. P042

Racemic Epinephrine

Racepinephrine

Rcra waste number P042

Renagladin

Renaglandin

Renaglandulin

Renaleptine

Renalina

Renoform

Renostypricin

Renostypticin

Renostyptin

SMP1_000227

ST069368

SUS-PHRINE SULFITE-FREE

Scurenaline

Septocaine

Simplene

Sindrenina

Soladren

Sphygmogenin

Stryptirenal

Styptirenal

Supracapsulin

Supradin

Supranefran

Supranephrane

Supranephrine

Supranol

Suprarenaline

Suprarenin

Suprel

Surenine

Surrenine

Sus-Phrine

Sus-phrine

Susphrine

Sympathin I

Takamina

Takamine

Tokamina

Tonogen

Twinject

Twinject 0.15

Twinject 0.3

Twinject 0.30

UNII-YKH834O4BH

Vaponefrin

Vasoconstrictine

Vasoconstrictor

Vasodrine

Vasoton

Vasotonin

adrenaline

bmse000316

d-Adrenaline

epinephrine

l-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol

l-Adrenalin

l-Adrenaline

l-Epinephine

l-Epinephrine (synthetic)

l-Epirenamine

l-Methylaminoethanolcatechol

levoepinephrine

nchembio747-comp9

5

Ribavirin

approved

Phase 2

948

36791-04-5

37542

Synonyms:

1-.beta.-D-Ribofuranosyl-1,2,4-triazolo-3-carboxamide

1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazole-3-carboxamide

1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-1,2,4-triazole-3-carboxamide

1-beta-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide

1-beta-D-Ribofuranosyl-1H-1,2,4-triazole-3-carboxamide

1-beta-D-ribofuranosyl-1-H-1,2,4-triazole-3-carboxamide

36791-04-5

437710-49-1

66510-90-5

AA-504/07617051

AB00430481

AC1L1XXZ

AC1Q1IDC

AC1Q4ZGS

AKOS001715163

BB_NC-0567

BPBio1_001195

BRN 0892462

BSPBio_001085

BSPBio_003352

C-Virin

CHEMBL1643

CID37542

Copegus

Copegus (TN)

Cotronak

D00423

DB00811

DRG-0028

DivK1c_000782

Drug: Ribavirin

EU-0101063

FT-0082885

HMS2090L15

HMS2094O09

HMS502H04

HSDB 6513

ICN-1229

IDI1_000782

Ibavyr

KBio1_000782

KBio2_002328

KBio2_004896

KBio2_007464

KBio3_002854

KBioGR_001804

KBioSS_002331

KS-1104

LS-1241

Lopac0_001063

MLS000028486

MLS002222317

Moderiba

MolPort-002-507-104

MolPort-002-885-856

NCGC00090726-01

NCGC00090726-03

NCGC00090726-04

NCGC00090726-05

NCGC00090726-06

NCGC00090726-07

NINDS_000782

NSC 163039

NSC163039

Prestwick3_000993

R 9644

R-964

R9644_SIGMA

RBV

RG-964

RIBAV

RTC

RTCA

RTP

Ravanex

Rebetol

Rebetol (TN)

Rebetron

Rebretron

Ribacine

Ribamide

Ribamidil

Ribamidyl

Ribasphere

Ribasphere (TN)

Ribasphere Ribapak

Ribav

Ribavirin

Ribavirin (JAN/USP/INN)

Ribavirin Capsules

Ribavirin Triphosphate

Ribavirin [USAN:INN]

Ribavirin-TP

Ribavirina

Ribavirina [INN-Spanish]

Ribavirine

Ribavirine [INN-French]

Ribavirinum

Ribavirinum [INN-Latin]

Ribovirin

Ro 20-9963/000

Ro-20-9963

S2504_Selleck

SCH 18908

SMP1_000261

SMR000058315

SPECTRUM1503938

SR-01000076112-3

Spectrum3_001876

Spectrum4_001252

Spectrum5_002075

Spectrum_001826

Tribavirin

UNII-49717AWG6K

Varazid

Vilona

Viramid

Viramide

Virazid

Virazide

Virazole

Virazole (Ribavirin) Inhalation Solution

Virazole (TN)

Virazole 5'-triphosphate

ZINC01035331

ribavirin

6

Racepinephrine

Phase 2, Phase 1

834

7

Immunologic Factors

Phase 2, Phase 1

18483

8

Epinephryl borate

Phase 2, Phase 1

834

9

Antiviral Agents

Phase 2

8071

10

Antimetabolites

Phase 2

9454

11

Anti-Infective Agents

Phase 2

17220

Interventional clinical trials:

id	Name	Status	NCT ID	Phase
1	Study to Evalutate Long-term Immunity of Hantavax in High Risk Population of HFRS	Completed	NCT02360514	Phase 3
2	Phase 2a Immunogenicity Study of Hantaan/Puumala Virus DNA Vaccine for Prevention of Hemorrhagic Fever	Recruiting	NCT02116205	Phase 2
3	Ribavirin for Hemorrhagic Fever With Renal Syndrome	Enrolling by invitation	NCT00623168	Phase 2
4	Ribavirin for Hemorrhagic Fever With Renal Syndrome in Germany	Enrolling by invitation	NCT00868946	Phase 2
5	Palifermin in Preventing Oral Mucositis Caused by Chemotherapy and/or Radiation Therapy in Young Patients Undergoing Stem Cell Transplant	Withdrawn	NCT00728585	Phase 2
6	Study to Evaluate the Safety, Tolerability, and Immunogenicity of Hantaan and Puumala Virus DNA Vaccines	Completed	NCT01502345	Phase 1
7	Diagnostic of Puumala Virus Infection in France	Recruiting	NCT02455375
8	Cohort of Patients Infected by an Arbovirus	Recruiting	NCT01099852
9	Phenotyping IBS: Perceptions and Modulations of Visceral Sensations	Recruiting	NCT02693730

Search NIH Clinical Center for Hemorrhagic Fever with Renal Syndrome

Cochrane evidence based reviews: hemorrhagic fever with renal syndrome

Genetic Tests for Hemorrhagic Fever with Renal Syndrome

Anatomical Context for Hemorrhagic Fever with Renal Syndrome

Sources:
³³MalaCards, ¹⁶FMA
See all MalaCards sources

MalaCards organs/tissues related to Hemorrhagic Fever with Renal Syndrome:

³³

Lung, Kidney, T cells, Heart, Liver, Prostate, Eye

FMA organs/tissues related to Hemorrhagic Fever with Renal Syndrome:

¹⁶

Kidney

Animal Models for Hemorrhagic Fever with Renal Syndrome or affiliated genes

Sources:
³⁸MGI
See all MalaCards sources

MGI Mouse Phenotypes related to Hemorrhagic Fever with Renal Syndrome:

³⁸

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system	MP:0005385	6.6	B2M, CD40LG, CRP, ICAM1, IL6, ITGB3
2	hematopoietic system	MP:0005397	6.6	B2M, CD40LG, ICAM1, IL6, ITGB3, SEMA4D
3	immune system	MP:0005387	6.4	B2M, CD40LG, CRP, ICAM1, IL6, ITGB3
4	homeostasis/metabolism	MP:0005376	6.4	B2M, CD40LG, CRP, ICAM1, IL6, ITGB3

Publications for Hemorrhagic Fever with Renal Syndrome

Sources:
⁵⁴PubMed
See all MalaCards sources

Articles related to Hemorrhagic Fever with Renal Syndrome:

(show top 50) (show all 361)

id	Title	Authors	Year
1	History of incomplete vaccination may associate with occurrence of hemorrhagic fever with renal syndrome with relieved clinical symptoms. (26636561)	Chen Y.... Zhao Y.	2016
2	Correction: Spatiotemporal Transmission Dynamics of Hemorrhagic Fever with Renal Syndrome in China, 2005-2012. (25799067)		2015
3	Acalculous cholecystitis associated with hemorrhagic fever with renal syndrome: a case report. (25982259)	Nicolas J.B.	2015
4	Community Acquired Severe Acute Kidney Injury Caused by Hantavirus-Induced Hemorrhagic Fever with Renal Syndrome Has a Favorable Outcome. (26139246)	Outinen T.K.... Mustonen J.	2015
5	Increased risk for lymphoma following hemorrhagic fever with renal syndrome. (24965350)	KlingstrAPm J.... Ljunggren H.G.	2014
6	Ecology and geography of hemorrhagic fever with renal syndrome in Changsha, China. (23819824)	Xiao H.... Zhao J.	2013
7	Hemorrhagic fever with renal syndrome and Crimean-Congo hemorrhagic fever as causes of acute undifferentiated febrile illness in Bulgaria. (23421884)	Christova I.... Mohareb E.	2013
8	A case of ruptured renal cortical arteriovenous malformation of the right testicular vein in hemorrhagic fever with renal syndrome. (23682233)	Lee S.M.... Noh J.W.	2013
9	A retrospective study of acute pancreatitis in patients with hemorrhagic fever with renal syndrome. (24345089)	Zhu Y.... Lu N.H.	2013
10	Serum TNF-I+, sTNFR1, IL-6, IL-8 and IL-10 levels in hemorrhagic fever with renal syndrome. (23603136)	Kyriakidis I.... Papa A.	2013
11	Hantavirus infection--hemorrhagic fever with renal syndrome: the first case series reported in Romania and review of the literature. (21678038)	Maftei I.D.... Covic A.	2012
12	Experience with extrarenal manifestations of hemorrhagic fever with renal syndrome in a tertiary care hospital in South Korea. (21292889)	Park K.H.... Jung S.I.	2011
13	Collective immunity of the population from endemic zones of hemorrhagic fever with renal syndrome in Kosovo. (20088164)	MuAsaj S.... Avsic-Zupanc T.	2009
14	Renal artery embolization of perirenal hematoma in hemorrhagic fever with renal syndrome: a case report. (17673847)	Choi H.S.... Yoon Y.	2007
15	Dynamic changes of apoptosis-inducing ligands and Th1/Th2 like subpopulations in Hantaan virus-induced hemorrhagic fever with renal syndrome. (16616877)	Liu J.M.... Jin B.Q.	2006
16	Comparison of virulence of various hantaviruses related to hemorrhagic fever with renal syndrome in newborn mouse model. (15070039)	Lokugamage K.... Takashima I.	2004
17	Hemorrhagic fever with renal syndrome: imported or native disease in the Zadar region]. (15011474)	Dzelalija B.... Avsic-Zupanc T.	2003
18	Hemorrhagic fever with renal syndrome presenting with intrauterine fetal death. A case report. (12971153)	Ma R.M.... Lao T.T.	2003
19	Serological analysis of hemorrhagic fever with renal syndrome (HFRS) patients in Far Eastern Russia and identification of the causative hantavirus genotype. (12898330)	Miyamoto H.... Takashima I.	2003
20	Hemorrhagic fever with renal syndrome: diagnostic problems with a known disease. (11526193)	Wichmann D.... Feldmann H.	2001
21	A case of torsade de pointes associated with hypopituitarism due to hemorrhagic fever with renal syndrome. (11410700)	Kim N.H.... Kang J.C.	2001
22	Epidemiological progresses of hemorrhagic fever with renal syndrome in China. (11593522)	Song G.	1999
23	Direct genetic detection of Dobrava virus in Greek and Albanian patients with hemorrhagic fever with renal syndrome. (8699076)	Antoniadis A.... Spiropoulou C.F.	1996
24	Genetic identification of a new Puumala virus strain causing severe hemorrhagic fever with renal syndrome in Germany. (7995985)	Pilaski J.... Nichol S.T.	1994
25	Virus-related acute renal failure: the clinical course and outcome of hemorrhagic fever with renal syndrome. (7914707)	Siamopoulos K.C.	1994
26	Elevated levels of total and Puumala virus-specific immunoglobulin E in the Scandinavian type of hemorrhagic fever with renal syndrome. (7496961)	Alexeyev O.A.... Juto P.	1994
27	Epidemiologic surveillance on the hemorrhagic fever with renal syndrome in China. (7908258)	Chen H.X.... Qiu F.X.	1993
28	Comparison of European isolates of viruses causing hemorrhagic fever with renal syndrome by a neutralization test. (1684888)	Niklasson B.... Tkachenko E.	1991
29	Effect of glucocorticoid hormones on the status of the hypothalamo-hypophyseal-adrenal system and endocrine function of the pancreas in patients with hemorrhagic fever with renal syndrome]. (1977953)	BystrovskiA- V.F.	1990
30	Hemorrhagic fever with renal syndrome: MR imaging of the kidney. (1971450)	Kim S.H.... Kim C.W.	1990
31	Outbreak of hemorrhagic fever with renal syndrome among U.S. Marines in Korea. (1973603)	Pon E.... Ksiazek T.G.	1990
32	Hemorrhagic fever with renal syndrome. (2647265)	Gan S.	1989
33	What is new and where are the problems in research on hemorrhagic fever with renal syndrome? (2573193)	Hsiang C.M.	1989
34	A clinical study of hemorrhagic fever with renal syndrome caused by Seoul virus infection. (2577257)	Park S.C.... Lee H.W.	1989
35	Hemorrhagic fever with renal syndrome. (2573914)	Lee H.W.... van der Groen G.	1989
36	Role of maternal antibody in protection from hemorrhagic fever with renal syndrome virus infection in rats. (2905596)	Zhang X.K.... Hashimoto N.	1988
37	Antibody to hemorrhagic fever with renal syndrome viruses (Hantaviruses) in the United States. (2891295)	Forthal D.N.... McCormick J.B.	1987
38	Cats--source of protection or infection? A case-control study of hemorrhagic fever with renal syndrome. (2889355)	Xu Z.Y.... Tsai T.F.	1987
39	Hemorrhagic fever with renal syndrome--a clinical perspective. (2867491)	McKee K.T.... Peters C.J.	1985
40	Isolation of a virus related to hemorrhagic fever with renal syndrome from urban rats in a nonendemic area. (6143783)	Sugiyama K.... Kitamura T.	1984
41	Antigenic differences between two viruses, isolated in Japan and Korea, that cause hemorrhagic fever with renal syndrome. (6207309)	Yamanishi K.... Tanishita O.	1984
42	Features of circulation of hemorrhagic fever with renal syndrome (HFRS) virus among small mammals in the European U.S.S.R. (6220688)	Gavrilovskaya I.N.... Chumakov M.P.	1983
43	Isolation of hemorrhagic fever with renal syndrome (HFRS) virus from a tumor specimen in a rat. (6146307)	Yamanishi K.... Kurata T.	1983
44	A preliminary report on hemorrhagic fever with renal syndrome in China. (6137329)	Jiang Y.T.	1983
45	Hemorrhagic fever with renal syndrome (HFRS). (6134332)	Lee H.W.	1982
46	Hemorrhagic fever with renal syndrome in Finland: ecology and virology of nephropathia epidemica. (6134333)	Brummer-Korvenkontio M.... Vaheri A.	1982
47	Seroepidemiologic study of epidemic hemorrhagic fever with renal syndrome in China. (6114815)	Jiang Y.T.... Song G.C.	1981
48	GEOGRAPHICAL DISTRIBUTION OF HEMORRHAGIC FEVER WITH RENAL SYNDROME. (14196952)	POVALISHINA T.P.... YANKOVSKII A.K.	1964
49	(18394063)
50	(16809096)

Genes related to Hemorrhagic Fever with Renal Syndrome

Sources:
²⁰GeneCards, ¹²DISEASES
See all MalaCards sources

Genes related to Hemorrhagic Fever with Renal Syndrome:

(show all 13)

- Elite gene

- Cancer Census gene in COSMIC

id	Symbol	Description	Score	Implication
1	CD40LG	CD40 Ligand	25.49	DISEASES inferred ¹² GeneCards inferred via : Publications (show sections)
2	CRP	C-Reactive Protein, Pentraxin-Related	23.42	DISEASES inferred ¹² GeneCards inferred via : Publications (show sections)
3	B2M	Beta-2-Microglobulin	23.26	DISEASES inferred ¹² GeneCards inferred via : Publications (show sections)
4	IL6	Interleukin 6	23.23	DISEASES inferred ¹² GeneCards inferred via : Publications (show sections)
5	SEMA4D	Semaphorin 4D	23.14	DISEASES inferred ¹² GeneCards inferred via : Publications (show sections)
6	TNF	Tumor Necrosis Factor	23.10	DISEASES inferred ¹² GeneCards inferred via : Publications (show sections)
7	VTN	Vitronectin	22.68	DISEASES inferred ¹² GeneCards inferred via : Publications (show sections)
8	CD163	CD163 Molecule	22.43	DISEASES inferred ¹² GeneCards inferred via : Publications (show sections)
9	HLA-DRB5	Major Histocompatibility Complex, Class II, DR Beta 5	22.32	DISEASES inferred ¹² GeneCards inferred via : Publications (show sections)
10	HLA-DRB1	Major Histocompatibility Complex, Class II, DR Beta 1	22.27	DISEASES inferred ¹² GeneCards inferred via : Publications (show sections)
11	ITGB3	Integrin Subunit Beta 3	22.06	DISEASES inferred ¹² GeneCards inferred via : Publications (show sections)
12	SERPINC1	Serpin Family C Member 1	22.05	DISEASES inferred ¹² GeneCards inferred via : Publications (show sections)
13	ICAM1	Intercellular Adhesion Molecule 1	22.04	DISEASES inferred ¹² GeneCards inferred via : Publications (show sections)

Variations for Hemorrhagic Fever with Renal Syndrome

Expression for genes affiliated with Hemorrhagic Fever with Renal Syndrome

Sources:
¹⁷Gene Expression Omnibus DataSets
See all MalaCards sources

Search GEO for disease gene expression data for Hemorrhagic Fever with Renal Syndrome.

Pathways for genes affiliated with Hemorrhagic Fever with Renal Syndrome

Sources:
⁵²PathCards, ⁵⁵QIAGEN, ⁵⁶R&D Systems, ³¹KEGG, ³⁹NCBI BioSystems Database, ⁶²Thomson Reuters, ⁵⁸SinoBiological, ⁵⁷Reactome
See all MalaCards sources

Pathways related to Hemorrhagic Fever with Renal Syndrome according to GeneCards Suite gene sharing:

(show all 27)

id	Super pathways	Score	Top Affiliating Genes
1	LDL Oxidation in Atherogenesis⁵⁵	9.6	ICAM1, TNF
2	Dendritic Cells Developmental Lineage Pathway⁵⁶	9.4	CD163, IL6, TNF
3	NF-kappa B signaling pathway³¹	9.4	CD40LG, ICAM1, TNF
4	Cytokines and Inflammatory Response³⁹	9.3	HLA-DRB1, IL6, TNF
5	Immune response_MIF-mediated glucocorticoid regulation⁶²	9.3	ICAM1, IL6, TNF
6	African trypanosomiasis³¹	9.3	ICAM1, IL6, TNF
7	AGE-RAGE signaling pathway in diabetic complications³¹	9.3	ICAM1, IL6, TNF
8	Spinal Cord Injury³⁹	9.3	ICAM1, IL6, TNF
9	TNF signaling pathway³¹	9.3	ICAM1, IL6, TNF
10	TNF Signaling (sino)⁵⁸ Show member pathways TNF Signaling⁵⁸ NF-kB (NFkB) Pathway⁵⁸ Death Receptor Signaling⁵⁸ TNF Superfamily Pathway: Human Ligand-Receptor Interactions and their Associated Functions⁵⁶ TNFs bind their physiological receptors⁵⁷	9.1	B2M, CD40LG, HLA-DRB5, TNF
11	Malaria³¹	9.1	CD40LG, ICAM1, IL6, TNF
12	IgA-Producing B Cells in the Intestine⁵⁶	9.1	CD40LG, ICAM1, IL6, TNF
13	Selenium Pathway³⁹ Show member pathways thioredoxin pathway³⁹	9.0	CRP, ICAM1, IL6, TNF
14	Staphylococcus aureus infection³¹	9.0	HLA-DRB1, HLA-DRB5, ICAM1
15	amb2 Integrin signaling³⁹	8.9	ICAM1, IL6, TNF, VTN
16	Toxoplasmosis³¹ Show member pathways Leishmaniasis³¹	8.9	CD40LG, HLA-DRB1, HLA-DRB5, TNF
17	Tuberculosis³¹	8.9	HLA-DRB1, HLA-DRB5, IL6, TNF
18	Proteoglycans in cancer³¹	8.8	IL6, ITGB3, TNF, VTN
19	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers⁵⁶	8.8	CD163, IL6, ITGB3, TNF
20	Cell adhesion molecules (CAMs)³¹	8.7	CD40LG, HLA-DRB1, HLA-DRB5, ICAM1
21	Interferon gamma signaling⁵⁷ Show member pathways Interferon Signaling⁵⁷ Regulation of IFNG signaling⁵⁷	8.7	B2M, HLA-DRB1, HLA-DRB5, ICAM1
22	HTLV-I infection³¹	8.3	HLA-DRB1, HLA-DRB5, ICAM1, IL6, TNF
23	Influenza A³¹ Show member pathways Herpes simplex infection³¹ Measles³¹	8.3	HLA-DRB1, HLA-DRB5, ICAM1, IL6, TNF
24	Rheumatoid arthritis³¹	8.3	HLA-DRB1, HLA-DRB5, ICAM1, IL6, TNF
25	Hematopoietic cell lineage³¹	8.2	HLA-DRB1, HLA-DRB5, IL6, ITGB3, TNF
26	Allograft rejection³⁹ ³¹ Show member pathways Antigen processing and presentation³¹ Viral myocarditis³¹ Intestinal immune network for IgA production³¹ CTL Mediated Apoptosis⁵⁵ THC Differentiation Pathway⁵⁵ Allograft Rejection³⁹ Asthma³¹ Autoimmune thyroid disease³¹ Type I diabetes mellitus³¹ Graft-versus-host disease³¹ Inflammatory bowel disease (IBD)³¹	7.8	B2M, CD40LG, HLA-DRB1, HLA-DRB5, ICAM1, IL6
27	Immune System⁵⁷ Show member pathways Innate Immune System⁵⁷ Adaptive Immune System⁵⁷	6.5	B2M, CD40LG, CRP, HLA-DRB1, HLA-DRB5, ICAM1

GO Terms for genes affiliated with Hemorrhagic Fever with Renal Syndrome

Sources:
¹⁸Gene Ontology
See all MalaCards sources

Cellular components related to Hemorrhagic Fever with Renal Syndrome according to GeneCards Suite gene sharing:

id	Name	GO ID	Score	Top Affiliating Genes
1	external side of plasma membrane	GO:0009897	8.7	B2M, CD40LG, HLA-DRB1, HLA-DRB5, IL6

Biological processes related to Hemorrhagic Fever with Renal Syndrome according to GeneCards Suite gene sharing:

(show all 23)

id	Name	GO ID	Score	Top Affiliating Genes
1	regulation of immunoglobulin secretion	GO:0051023	10.5	CD40LG, TNF
2	epithelial cell proliferation involved in salivary gland morphogenesis	GO:0060664	10.5	IL6, TNF
3	negative regulation of alkaline phosphatase activity	GO:0010693	10.5	SEMA4D, TNF
4	negative regulation of lipid storage	GO:0010888	10.4	IL6, TNF
5	leukocyte cell-cell adhesion	GO:0007159	10.3	CD40LG, ICAM1
6	negative regulation of osteoblast differentiation	GO:0045668	10.3	SEMA4D, TNF
7	immunoglobulin production involved in immunoglobulin mediated immune response	GO:0002381	10.2	HLA-DRB1, HLA-DRB5
8	regulation of interleukin-10 secretion	GO:2001179	10.2	HLA-DRB1, HLA-DRB5
9	T-helper 1 type immune response	GO:0042088	10.2	HLA-DRB1, HLA-DRB5
10	antigen processing and presentation	GO:0019882	10.0	HLA-DRB1, HLA-DRB5
11	positive regulation of nitric oxide biosynthetic process	GO:0045429	9.9	ICAM1, IL6, TNF
12	regulation of immune response	GO:0050776	9.9	B2M, CD40LG, ICAM1
13	defense response to Gram-positive bacterium	GO:0050830	9.8	B2M, CRP, IL6, TNF
14	platelet activation	GO:0030168	9.6	CD40LG, IL6, ITGB3
15	regulation of cell shape	GO:0008360	9.4	ICAM1, IL6, SEMA4D
16	positive regulation of peptidyl-tyrosine phosphorylation	GO:0050731	9.4	ICAM1, IL6, SEMA4D, VTN
17	cellular response to lipopolysaccharide	GO:0071222	9.3	ICAM1, IL6, TNF
18	positive regulation of NF-kappaB transcription factor activity	GO:0051092	9.2	CD40LG, ICAM1, IL6, TNF
19	cytokine-mediated signaling pathway	GO:0019221	9.1	HLA-DRB1, HLA-DRB5, ICAM1, IL6
20	viral entry into host cell	GO:0046718	9.1	HLA-DRB1, ICAM1, ITGB3
21	leukocyte migration	GO:0050900	9.0	ICAM1, ITGB3, TNF
22	cell adhesion	GO:0007155	8.7	ICAM1, ITGB3, SEMA4D, VTN
23	immune response	GO:0006955	8.2	HLA-DRB1, HLA-DRB5, IL6, TNF, VTN