HFRS
MCID: HMR004
MIFTS: 61

Hemorrhagic Fever with Renal Syndrome (HFRS) malady

Infectious diseases, Rare diseases, Nephrological diseases categories
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Summaries for Hemorrhagic Fever with Renal Syndrome

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Disease Ontology:8 A viral infectious disease that is a hemorrhagic fever, located in kidney, has material basis in hantaan virus, has material basis in dobrava-belgrade virus, has material basis in seoul virus, or has material basis in puumala virus, which are carried and transmitted by rodents. the infection has symptom headache, has symptom fever, has symptom muscle pains, has symptom facial flush, has symptom petechiae, has symptom hemorrhagic features, has symptom proteinuria, and has symptom renal failure.

MalaCards based summary: Hemorrhagic Fever with Renal Syndrome, also known as hantavirus fever, is related to hemorrhagic fever and thrombocytopenia, and has symptoms including fever/chilling, asthenia/fatigue/weakness and chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis. An important gene associated with Hemorrhagic Fever with Renal Syndrome is HLA-DRB4 (major histocompatibility complex, class II, DR beta 4), and among its related pathways are Immune response Antigen presentation by MHC class II and Staphylococcus aureus infection. The compounds clopidogrel and obtustatin have been mentioned in the context of this disorder. Affiliated tissues include kidney, kidney and lung.

Wikipedia:65 Hantavirus hemorrhagic fever with renal syndrome (HFRS) is a group of clinically similar illnesses... more...

Aliases & Classifications for Hemorrhagic Fever with Renal Syndrome

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Sources:
8Disease Ontology, 10DISEASES, 48Orphanet, 62UMLS, 27ICD9CM, 34MeSH, 57SNOMED-CT, 39NCIt, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet, 25ICD10
See all sources

Hemorrhagic Fever with Renal Syndrome, Aliases & Descriptions:

Name: Hemorrhagic Fever with Renal Syndrome 8 10 62
Hantavirus Fever 48 62
Hantavirosis 48 62
Haemorrhagic Fever with Renal Syndrome 62
Hemorrhagic Fever - Renal Syndrome 48
 
Hemorrhagic Nephrosonephritis 8
Hemorrhagic Fever, Russian 8
Puumala Virus Nephropathy 8
Hfrs 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases, Rare diseases
Anatomical: Nephrological diseases


External Ids:

Disease Ontology8 DOID:11266
ICD9CM27 078.6
MeSH34 D006480
NCIt39 C84753
MESH via Orphanet35 C535630, D006480
ICD10 via Orphanet26 A98.5+, N08.0*
UMLS via Orphanet63 C0019101, C2930957
ICD1025 A98.5

Related Diseases for Hemorrhagic Fever with Renal Syndrome

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Diseases related to Hemorrhagic Fever with Renal Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 55)
idRelated DiseaseScoreTop Affiliating Genes
1hemorrhagic fever32.9CD40LG
2thrombocytopenia30.3ITGB3, ITGA2B, CD40LG
3nephropathia epidemica10.8
4hantavirus pulmonary syndrome10.6
5korean hemorrhagic fever10.6
6acute pancreatitis10.6
7pancreatitis10.6
8hypopituitarism10.5
9hypertension10.4
10viral hemorrhagic fever10.4
11endotheliitis10.4
12acute myocardial infarction10.3
13alport syndrome10.3
14hemophagocytic lymphohistiocytosis10.3
15hepatitis10.3
16hepatitis b10.3
17myocardial infarction10.3
18leptospirosis10.3
19orchitis10.3
20scrub typhus10.3
21crimean-congo hemorrhagic fever10.3
22balkan hemorrhagic fever10.3
23metabolic acidosis10.3
24arteriovenous malformation10.3
25disseminated intravascular coagulation10.3
26labyrinthitis10.3
27peritonitis10.3
28typhus10.3
29hereditary pancreatitis10.3
30toxic epidermal necrolysis10.3
31pulmonary function10.3
32blindness10.3
33autoimmune thyroiditis10.2CD58, HLA-DRB4
34autoimmune thrombocytopenic purpura10.1ITGA2B, ITGB3
35bleeding disorder, platelet-type, 16, autosomal dominant10.1ITGB3, ITGA2B
36glanzmann's thrombasthenia10.1ITGB3, ITGA2B
37bernard-soulier syndrome10.1ITGA2B, ITGB3
38primary biliary cirrhosis10.1CD58, CD40LG
39systemic scleroderma10.1CD58, CD40LG
40tetanus10.0CD40LG, CD58
41hypersensitivity reaction type ii disease10.0CD58, CD40LG, HLA-DRB4
42lupus nephritis10.0VTN, CD40LG
43berger disease10.0CD40LG, VTN
44diabetic retinopathy9.9VTN, ITGB3
45nephritis9.9VTN, CD40LG
46multiple sclerosis9.8VTN, HLA-DRB5, CD58
47viral infectious disease9.8VTN, CD40LG, CD58
48glomerulonephritis9.8VTN, CD40LG
49diabetes mellitus9.8VTN, CD40LG, ITGA2B
50acute erythroid leukemia9.7ITGA2B, ITGB3, VTN

Graphical network of the top 20 diseases related to Hemorrhagic Fever with Renal Syndrome:



Diseases related to hemorrhagic fever with renal syndrome

Symptoms for Hemorrhagic Fever with Renal Syndrome

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Symptoms:

48 (show all 33)
  • fever/chilling
  • asthenia/fatigue/weakness
  • chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis
  • conjunctival injection/chemosis/red eye
  • photophobia
  • acute abdominal pain/colic
  • abnormal hepatic enzymes/transaminases
  • abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
  • lung/pulmonary infiltrates
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • atelectasia/pulmonary collapse
  • renal tubular defect/tubulopathy
  • interstitial nephropathy
  • renal failure
  • proteinuria
  • pollakiuria/polyuria/dysuria/anuria/acute urine retention/oliguria
  • facial pain/cephalalgia/migraine
  • myalgia/muscular pain
  • articular/joint pain/arthralgia
  • hyperleukocytosis/leukocytosis
  • thrombocytopenia/thrombopenia
  • hypoproteinemia
  • transient amaurosis/acute visual trouble
  • myopia
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • hemoptysis
  • myocardium anomalies/myocarditis
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
  • cardiac rhythm disorder/arrhythmia
  • chronic arterial hypertension
  • hypotension
  • intracranial/cerebral/meningeal hemorrhage
  • early death/lethality

HPO human phenotypes related to Hemorrhagic Fever with Renal Syndrome:

(show all 28)
id Description Frequency HPO Source Accession
1 abnormality of temperature regulation hallmark (90%) HP:0004370
2 renal insufficiency typical (50%) HP:0000083
3 abnormality of the renal tubule typical (50%) HP:0000091
4 proteinuria typical (50%) HP:0000093
5 conjunctivitis typical (50%) HP:0000509
6 photophobia typical (50%) HP:0000613
7 thrombocytopenia typical (50%) HP:0001873
8 leukocytosis typical (50%) HP:0001974
9 abdominal pain typical (50%) HP:0002027
10 migraine typical (50%) HP:0002076
11 respiratory insufficiency typical (50%) HP:0002093
12 abnormality of the pleura typical (50%) HP:0002103
13 pulmonary infiltrates typical (50%) HP:0002113
14 arthralgia typical (50%) HP:0002829
15 elevated hepatic transaminases typical (50%) HP:0002910
16 hypoproteinemia typical (50%) HP:0003075
17 myalgia typical (50%) HP:0003326
18 atelectasis typical (50%) HP:0100750
19 myopia occasional (7.5%) HP:0000545
20 hypertension occasional (7.5%) HP:0000822
21 abnormality of the myocardium occasional (7.5%) HP:0001637
22 abnormality of the pericardium occasional (7.5%) HP:0001697
23 hemoptysis occasional (7.5%) HP:0002105
24 intracranial hemorrhage occasional (7.5%) HP:0002170
25 gastrointestinal hemorrhage occasional (7.5%) HP:0002239
26 hypotension occasional (7.5%) HP:0002615
27 arrhythmia occasional (7.5%) HP:0011675
28 amaurosis fugax occasional (7.5%) HP:0100576

Drugs & Therapeutics for Hemorrhagic Fever with Renal Syndrome

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Drug clinical trials:

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Search NIH Clinical Center for Hemorrhagic Fever with Renal Syndrome

Genetic Tests for Hemorrhagic Fever with Renal Syndrome

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Anatomical Context for Hemorrhagic Fever with Renal Syndrome

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MalaCards organs/tissues related to Hemorrhagic Fever with Renal Syndrome:

32
Kidney, Lung, T cells, Eye, Testes, B cells, Endothelial, Heart, Liver, Pancreas, Neutrophil

FMA organs/tissues related to Hemorrhagic Fever with Renal Syndrome:

14
Kidney

Animal Models for Hemorrhagic Fever with Renal Syndrome or affiliated genes

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Publications for Hemorrhagic Fever with Renal Syndrome

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Articles related to Hemorrhagic Fever with Renal Syndrome:

(show top 50)    (show all 330)
idTitleAuthorsYear
1
Increased risk for lymphoma following hemorrhagic fever with renal syndrome. (24965350)
2014
2
Animal reservoir, natural and socioeconomic variations and the transmission of hemorrhagic Fever with renal syndrome in chenzhou, china, 2006-2010. (24421910)
2014
3
Ecology and geography of hemorrhagic fever with renal syndrome in Changsha, China. (23819824)
2013
4
Hemorrhagic fever with renal syndrome and Crimean-Congo hemorrhagic fever as causes of acute undifferentiated febrile illness in Bulgaria. (23421884)
2013
5
A case of ruptured renal cortical arteriovenous malformation of the right testicular vein in hemorrhagic fever with renal syndrome. (23682233)
2013
6
A retrospective study of acute pancreatitis in patients with hemorrhagic fever with renal syndrome. (24345089)
2013
7
Serum TNF-I+, sTNFR1, IL-6, IL-8 and IL-10 levels in hemorrhagic fever with renal syndrome. (23603136)
2013
8
Correction: Investigating the Effects of Food Available and Climatic Variables on the Animal Host Density of Hemorrhagic Fever with Renal Syndrome in Changsha, China. (24058426)
2013
9
Hantavirus infection--hemorrhagic fever with renal syndrome: the first case series reported in Romania and review of the literature. (21678038)
2012
10
Experience with extrarenal manifestations of hemorrhagic fever with renal syndrome in a tertiary care hospital in South Korea. (21292889)
2011
11
Increased serum fibronectin levels in patients with hemorrhagic fever with renal syndrome. (19701604)
2010
12
Collective immunity of the population from endemic zones of hemorrhagic fever with renal syndrome in Kosovo. (20088164)
2009
13
Renal artery embolization of perirenal hematoma in hemorrhagic fever with renal syndrome: a case report. (17673847)
2007
14
Dynamic changes of apoptosis-inducing ligands and Th1/Th2 like subpopulations in Hantaan virus-induced hemorrhagic fever with renal syndrome. (16616877)
2006
15
Comparison of virulence of various hantaviruses related to hemorrhagic fever with renal syndrome in newborn mouse model. (15070039)
2004
16
Hemorrhagic fever with renal syndrome: imported or native disease in the Zadar region]. (15011474)
2003
17
Hemorrhagic fever with renal syndrome presenting with intrauterine fetal death. A case report. (12971153)
2003
18
Serological analysis of hemorrhagic fever with renal syndrome (HFRS) patients in Far Eastern Russia and identification of the causative hantavirus genotype. (12898330)
2003
19
Hemorrhagic fever with renal syndrome: diagnostic problems with a known disease. (11526193)
2001
20
A case of torsade de pointes associated with hypopituitarism due to hemorrhagic fever with renal syndrome. (11410700)
2001
21
Epidemiological progresses of hemorrhagic fever with renal syndrome in China. (11593522)
1999
22
Direct genetic detection of Dobrava virus in Greek and Albanian patients with hemorrhagic fever with renal syndrome. (8699076)
1996
23
Genetic identification of a new Puumala virus strain causing severe hemorrhagic fever with renal syndrome in Germany. (7995985)
1994
24
Virus-related acute renal failure: the clinical course and outcome of hemorrhagic fever with renal syndrome. (7914707)
1994
25
Elevated levels of total and Puumala virus-specific immunoglobulin E in the Scandinavian type of hemorrhagic fever with renal syndrome. (7496961)
1994
26
Epidemiologic surveillance on the hemorrhagic fever with renal syndrome in China. (7908258)
1993
27
Comparison of European isolates of viruses causing hemorrhagic fever with renal syndrome by a neutralization test. (1684888)
1991
28
Effect of glucocorticoid hormones on the status of the hypothalamo-hypophyseal-adrenal system and endocrine function of the pancreas in patients with hemorrhagic fever with renal syndrome]. (1977953)
1990
29
Hemorrhagic fever with renal syndrome: MR imaging of the kidney. (1971450)
1990
30
Outbreak of hemorrhagic fever with renal syndrome among U.S. Marines in Korea. (1973603)
1990
31
Hemorrhagic fever with renal syndrome. (2647265)
1989
32
What is new and where are the problems in research on hemorrhagic fever with renal syndrome? (2573193)
1989
33
A clinical study of hemorrhagic fever with renal syndrome caused by Seoul virus infection. (2577257)
1989
34
Hemorrhagic fever with renal syndrome. (2573914)
1989
35
Hemorrhagic fever with renal syndrome in Korea. (2568676)
1989
36
Role of maternal antibody in protection from hemorrhagic fever with renal syndrome virus infection in rats. (2905596)
1988
37
Antibody to hemorrhagic fever with renal syndrome viruses (Hantaviruses) in the United States. (2891295)
1987
38
Cats--source of protection or infection? A case-control study of hemorrhagic fever with renal syndrome. (2889355)
1987
39
Characterization of glycoproteins of viruses causing hemorrhagic fever with renal syndrome (HFRS) using monoclonal antibodies. (2422813)
1986
40
Hemorrhagic fever with renal syndrome--a clinical perspective. (2867491)
1985
41
Isolation of a virus related to hemorrhagic fever with renal syndrome from urban rats in a nonendemic area. (6143783)
1984
42
Antigenic differences between two viruses, isolated in Japan and Korea, that cause hemorrhagic fever with renal syndrome. (6207309)
1984
43
Features of circulation of hemorrhagic fever with renal syndrome (HFRS) virus among small mammals in the European U.S.S.R. (6220688)
1983
44
Isolation of hemorrhagic fever with renal syndrome (HFRS) virus from a tumor specimen in a rat. (6146307)
1983
45
A preliminary report on hemorrhagic fever with renal syndrome in China. (6137329)
1983
46
Detection of antibody against hemorrhagic fever with renal syndrome (HFRS) virus in sera of house rats captured in port areas of Japan. (6408289)
1983
47
Hemorrhagic fever with renal syndrome (HFRS). (6134332)
1982
48
Hemorrhagic fever with renal syndrome in Finland: ecology and virology of nephropathia epidemica. (6134333)
1982
49
Seroepidemiologic study of epidemic hemorrhagic fever with renal syndrome in China. (6114815)
1981
50
GEOGRAPHICAL DISTRIBUTION OF HEMORRHAGIC FEVER WITH RENAL SYNDROME. (14196952)
1964

Variations for Hemorrhagic Fever with Renal Syndrome

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Expression for genes affiliated with Hemorrhagic Fever with Renal Syndrome

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Expression patterns in normal tissues for genes affiliated with Hemorrhagic Fever with Renal Syndrome

Search GEO for disease gene expression data for Hemorrhagic Fever with Renal Syndrome.

Pathways for genes affiliated with Hemorrhagic Fever with Renal Syndrome

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Pathways related to Hemorrhagic Fever with Renal Syndrome according to GeneCards/GeneDecks:

(show all 45)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Immune response IL 22 signaling pathway60
G protein signaling N RAS regulation pathway60
9.6HLA-DRB5, HLA-DRB4
29.6HLA-DRB5, HLA-DRB4
39.6HLA-DRB4, HLA-DRB5
4
Show member pathways
9.6HLA-DRB4, HLA-DRB5
5
Show member pathways
9.6HLA-DRB4, HLA-DRB5
6
Show member pathways
9.6HLA-DRB4, HLA-DRB5
79.6HLA-DRB4, HLA-DRB5
8
Show member pathways
9.6HLA-DRB4, HLA-DRB5
9
Show member pathways
9.5CD58, ITGB3
109.5CD40LG, ITGB3
119.3ITGB3, ITGA2B
129.3ITGB3, ITGA2B
139.3ITGB3, ITGA2B
149.3ITGA2B, ITGB3
15
Show member pathways
9.3ITGA2B, ITGB3
169.3ITGA2B, ITGB3
179.3ITGA2B, ITGB3
18
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy37
9.3ITGA2B, ITGB3
199.3ITGA2B, ITGB3
20
Show member pathways
9.3ITGA2B, ITGB3
219.2CD40LG, VTN
229.2CD58, HLA-DRB4, HLA-DRB5
23
Show member pathways
9.1ITGB3, VTN
249.1ITGB3, VTN
259.1VTN, ITGB3
26
Show member pathways
Proteogylcan syndecan-mediated signaling events37
9.1VTN, ITGB3
27
Show member pathways
9.1ITGB3, VTN
28
Show member pathways
9.1HLA-DRB5, HLA-DRB4, CD40LG
29
Show member pathways
9.1HLA-DRB5, HLA-DRB4, CD40LG
30
Show member pathways
9.1HLA-DRB5, HLA-DRB4, CD40LG
31
Show member pathways
9.1HLA-DRB5, HLA-DRB4, CD40LG
329.1HLA-DRB5, HLA-DRB4, ITGB3
33
Show member pathways
8.9CD58, ITGA2B, ITGB3
348.7HLA-DRB5, HLA-DRB4, CD58, CD40LG
35
Show member pathways
8.5VTN, ITGB3, ITGA2B
368.5ITGA2B, ITGB3, VTN
378.5ITGA2B, ITGB3, VTN
38
Show member pathways
8.5ITGA2B, ITGB3, VTN
398.5ITGA2B, ITGB3, VTN
408.5ITGA2B, ITGB3, VTN
41
Show member pathways
8.5ITGA2B, ITGB3, VTN
42
Show member pathways
Integrin-mediated cell adhesion37
Focal Adhesion37
8.5ITGA2B, ITGB3, VTN
43
Show member pathways
8.4ITGA2B, ITGB3, HLA-DRB4, HLA-DRB5
44
Show member pathways
8.4HLA-DRB5, HLA-DRB4, ITGB3, ITGA2B
458.4ITGA2B, ITGB3, HLA-DRB4, HLA-DRB5

Compounds for genes affiliated with Hemorrhagic Fever with Renal Syndrome

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Compounds related to Hemorrhagic Fever with Renal Syndrome according to GeneCards/GeneDecks:

(show all 26)
idCompoundScoreTop Affiliating Genes
1clopidogrel44 50 24 1112.7CD40LG, ITGB3
2obtustatin619.7ITGB3, ITGA2B
3a 286982619.7ITGB3, ITGA2B
4bio 1211619.7ITGB3, ITGA2B
5leukadherin 1619.7ITGB3, ITGA2B
6tc-i 15619.6ITGB3, ITGA2B
7rhodostomin449.5ITGB3, VTN
8pmma449.5CD40LG, VTN
9silicone449.5CD40LG, VTN
10glutaraldehyde449.4CD40LG, VTN
11titanium449.4ITGB3, VTN
12dextran sulfate449.3VTN, CD40LG
13thalidomide44 50 61 1112.1CD40LG, VTN
14hyaluronic acid44 2410.1VTN, CD58, CD40LG
15aspirin44 50 28 2412.0CD40LG, ITGB3, VTN
16cisplatin44 50 61 1111.9CD40LG, CD58, VTN
17polyethylene glycol448.9CD40LG, VTN
18dexamethasone44 50 28 1111.8CD40LG, CD58, VTN
19aspartate448.7CD40LG, ITGB3, VTN
20lysine448.4VTN, ITGB3, ITGA2B, CD58
21tirofiban44 119.4CD40LG, ITGA2B, ITGB3, VTN
22abciximab44 119.4VTN, ITGB3, ITGA2B, CD40LG
23fibrinogen448.4VTN, ITGB3, ITGA2B, CD40LG
24adp44 28 2410.3VTN, ITGB3, ITGA2B, CD40LG
25cysteine448.3VTN, ITGB3, ITGA2B, CD40LG
26serine448.1VTN, ITGB3, ITGA2B, CD40LG

GO Terms for genes affiliated with Hemorrhagic Fever with Renal Syndrome

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Cellular components related to Hemorrhagic Fever with Renal Syndrome according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:0426139.8HLA-DRB5, HLA-DRB4
2integral component of lumenal side of endoplasmic reticulum membraneGO:0715569.8HLA-DRB4, HLA-DRB5
3clathrin-coated endocytic vesicle membraneGO:0306699.7HLA-DRB5, HLA-DRB4
4transport vesicle membraneGO:0306589.7HLA-DRB4, HLA-DRB5
5ER to Golgi transport vesicle membraneGO:0125079.6HLA-DRB5, HLA-DRB4
6platelet alpha granule membraneGO:0310929.6ITGA2B, ITGB3
7trans-Golgi network membraneGO:0325889.6HLA-DRB4, HLA-DRB5
8late endosome membraneGO:0319029.6HLA-DRB4, HLA-DRB5
9integrin complexGO:0083059.5ITGA2B, ITGB3
10endocytic vesicle membraneGO:0306669.5HLA-DRB4, HLA-DRB5
11alphav-beta3 integrin-vitronectin complexGO:0710629.4ITGB3, VTN
12external side of plasma membraneGO:0098978.8CD40LG, ITGA2B, HLA-DRB4, HLA-DRB5
13integral component of plasma membraneGO:0058878.4HLA-DRB4, ITGB3, ITGA2B, CD58, CD40LG
14extracellular vesicular exosomeGO:0700627.9HLA-DRB5, VTN, ITGB3, CD58
15plasma membraneGO:0058867.8HLA-DRB5, HLA-DRB4, ITGB3, ITGA2B, CD58, CD40LG

Biological processes related to Hemorrhagic Fever with Renal Syndrome according to GeneCards/GeneDecks:

(show all 27)
idNameGO IDScoreTop Affiliating Genes
1regulation of interleukin-4 productionGO:03267310.0HLA-DRB4, HLA-DRB5
2regulation of interleukin-10 secretionGO:20011799.9HLA-DRB4, HLA-DRB5
3immunoglobulin production involved in immunoglobulin mediated immune responseGO:0023819.9HLA-DRB4, HLA-DRB5
4humoral immune response mediated by circulating immunoglobulinGO:0024559.9HLA-DRB4, HLA-DRB5
5T-helper 1 type immune responseGO:0420889.9HLA-DRB5, HLA-DRB4
6inflammatory response to antigenic stimulusGO:0024379.9HLA-DRB4, HLA-DRB5
7detection of bacteriumGO:0160459.9HLA-DRB4, HLA-DRB5
8positive regulation of insulin secretion involved in cellular response to glucose stimulusGO:0357749.9HLA-DRB5, HLA-DRB4
9negative regulation of interferon-gamma productionGO:0326899.9HLA-DRB5, HLA-DRB4
10negative regulation of T cell proliferationGO:0421309.9HLA-DRB4, HLA-DRB5
11protein tetramerizationGO:0512629.8HLA-DRB4, HLA-DRB5
12interferon-gamma-mediated signaling pathwayGO:0603339.8HLA-DRB5, HLA-DRB4
13T cell costimulationGO:0312959.7HLA-DRB4, HLA-DRB5
14platelet aggregationGO:0705279.6ITGA2B, ITGB3
15leukocyte migrationGO:0509009.5CD58, ITGB3
16T cell receptor signaling pathwayGO:0508529.5HLA-DRB4, HLA-DRB5
17integrin-mediated signaling pathwayGO:0072299.4ITGA2B, ITGB3
18positive regulation of vascular endothelial growth factor receptor signaling pathwayGO:0309499.4VTN, ITGB3
19platelet degranulationGO:0025769.3ITGB3, ITGA2B
20antigen processing and presentation of exogenous peptide antigen via MHC class IIGO:0198869.3HLA-DRB4, HLA-DRB5
21positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.2ITGB3, VTN
22platelet activationGO:0301689.2CD40LG, ITGA2B, ITGB3
23blood coagulationGO:0075969.1CD58, ITGA2B, ITGB3
24immune responseGO:0069559.0VTN, HLA-DRB4, HLA-DRB5
25cell-matrix adhesionGO:0071608.9ITGA2B, ITGB3, VTN
26extracellular matrix organizationGO:0301988.7VTN, ITGB3, ITGA2B
27cell adhesionGO:0071558.5VTN, ITGB3, ITGA2B, CD58

Molecular functions related to Hemorrhagic Fever with Renal Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptide antigen bindingGO:0426059.6HLA-DRB4, HLA-DRB5
2extracellular matrix bindingGO:0508408.7ITGA2B, VTN

Products for genes affiliated with Hemorrhagic Fever with Renal Syndrome

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Sources for Hemorrhagic Fever with Renal Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet