MCID: HMR004
MIFTS: 56

Hemorrhagic Fever with Renal Syndrome

Categories: Infectious diseases, Rare diseases, Skin diseases, Nephrological diseases

Aliases & Classifications for Hemorrhagic Fever with Renal Syndrome

MalaCards integrated aliases for Hemorrhagic Fever with Renal Syndrome:

Name: Hemorrhagic Fever with Renal Syndrome 12 42 14 69
Hantavirosis 56 69
Hemorrhagic Fever-Renal Syndrome 56
Hemorrhagic Nephrosonephritis 12
Hemorrhagic Fever, Russian 12
Puumala Virus Nephropathy 12
Hantavirus Fever 56
Hfrs 12

Characteristics:

Orphanet epidemiological data:

56
hemorrhagic fever-renal syndrome
Prevalence: 1-9/1000000 (Europe); Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 56  
Rare infectious diseases


Summaries for Hemorrhagic Fever with Renal Syndrome

Disease Ontology : 12 A viral infectious disease that is a hemorrhagic fever, located in kidney, has material basis in Hantaan virus, has material basis in Dobrava-Belgrade virus, has material basis in Seoul virus, or has material basis in Puumala virus, which are carried and transmitted_by rodents. The infection has symptom headache, has symptom fever, has symptom muscle pains, has symptom facial flush, has symptom petechiae, has symptom hemorrhagic features, has symptom proteinuria, and has symptom renal failure.

MalaCards based summary : Hemorrhagic Fever with Renal Syndrome, also known as hantavirosis, is related to balkan hemorrhagic fever and hemophagocytic lymphohistiocytosis, and has symptoms including myopia, migraine and thrombocytopenia. An important gene associated with Hemorrhagic Fever with Renal Syndrome is CD40LG (CD40 Ligand), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Antibodies and Antibodies, Blocking have been mentioned in the context of this disorder. Affiliated tissues include kidney, t cells and testes, and related phenotypes are cardiovascular system and homeostasis/metabolism

Related Diseases for Hemorrhagic Fever with Renal Syndrome

Diseases related to Hemorrhagic Fever with Renal Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 307)
id Related Disease Score Top Affiliating Genes
1 balkan hemorrhagic fever 32.2 CD40LG IL10
2 hemophagocytic lymphohistiocytosis 30.1 IL10 IL6 TNF
3 hepatitis b 29.9 B2M IL10 TNF
4 lymphoma 28.9 ALB CD40LG IL10 IL6 TNF
5 myocardial infarction 27.9 ALB CD40LG CRP IL10 IL6 ITGB3
6 nephropathia epidemica 11.3
7 hantavirus pulmonary syndrome 11.3
8 korean hemorrhagic fever 11.2
9 hemorrhagic fever 11.0
10 pancreatitis, hereditary 10.9
11 smarca4-deficient sarcoma of thorax 10.8 IL6 TNF
12 aortic arch interruption 10.8 IL6 TNF
13 cutaneous leishmaniasis 10.8 IL6 TNF
14 superior limbic keratoconjunctivitis 10.8 IL6 ITGB3
15 solitary plasmacytoma of chest wall 10.8 B2M IL6
16 spirillary rat-bite fever 10.8 IL6 TNF
17 collagenopathy type 2 alpha 1 10.7 CRP IL6
18 toxoplasmosis 10.7 IL6 TNF
19 rickettsialpox 10.7 CD40LG TNF
20 lung disease 10.7 CD40LG TNF
21 crystal arthropathies 10.7 CRP IL6
22 submandibular gland disease 10.7 CD40LG TNF
23 dyslexia 5 10.7 IL6 TNF
24 shoulder impingement syndrome 10.7 CRP IL6
25 brachydactyly-distal symphalangism syndrome 10.7 CRP IL6
26 scrotal carcinoma 10.7 IL6 TNF
27 acquired polycythemia 10.7 CD40LG CRP
28 antigen-peptide-transporter 2 deficiency 10.7 IL6 TNF
29 cannabis dependence 10.6 CD40LG CRP
30 generalized atherosclerosis 10.6 CD40LG IL6
31 biemond syndrome 10.6 HLA-DRB1 TNF
32 migraine with brainstem aura 10.6 HLA-DRB1 TNF
33 pure autonomic failure 10.6 IL10 TNF
34 papilledema 10.6 IL6 TNF
35 congenital dyserythropoietic anemia 10.6 ALB TNF
36 acute ackee fruit intoxication 10.6 IL10 TNF
37 leiomyosarcoma 10.6 CD40LG CRP
38 cataract 25 10.6 ALB B2M
39 akaba hayasaka syndrome 10.6 B2M TNF
40 angiomatous meningioma 10.6 B2M CD40LG IL6
41 pancreatic vasoactive intestinal peptide producing tumor 10.6 CD40LG CRP
42 indolent myeloma 10.6 CD40LG IL6 TNF
43 x-linked dominant intellectual disability-epilepsy syndrome 10.6 CRP IL6
44 mosaic trisomy 1 10.6 HLA-DRB1 TNF
45 chronic mucocutaneous candidiasis 10.6 CD40LG CRP
46 foodborne botulism 10.6 CD40LG IL6 TNF
47 middle ear carcinoma 10.5 ALB CD40LG
48 multiple familial trichoepithelioma 10.5 IL10 TNF
49 human monocytic ehrlichiosis 10.5 CD40LG IL6 TNF
50 erythema elevatum diutinum 10.5 CRP IL6

Graphical network of the top 20 diseases related to Hemorrhagic Fever with Renal Syndrome:



Diseases related to Hemorrhagic Fever with Renal Syndrome

Symptoms & Phenotypes for Hemorrhagic Fever with Renal Syndrome

Human phenotypes related to Hemorrhagic Fever with Renal Syndrome:

56 32 (show all 32)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 myopia 56 32 occasional (7.5%) Occasional (29-5%) HP:0000545
2 migraine 56 32 frequent (33%) Frequent (79-30%) HP:0002076
3 thrombocytopenia 56 32 frequent (33%) Frequent (79-30%) HP:0001873
4 proteinuria 56 32 frequent (33%) Frequent (79-30%) HP:0000093
5 fatigue 56 32 hallmark (90%) Very frequent (99-80%) HP:0012378
6 renal insufficiency 56 32 frequent (33%) Frequent (79-30%) HP:0000083
7 photophobia 56 32 frequent (33%) Frequent (79-30%) HP:0000613
8 hypertension 56 32 occasional (7.5%) Occasional (29-5%) HP:0000822
9 myalgia 56 32 frequent (33%) Frequent (79-30%) HP:0003326
10 arrhythmia 56 32 occasional (7.5%) Occasional (29-5%) HP:0011675
11 fever 56 32 hallmark (90%) Very frequent (99-80%) HP:0001945
12 respiratory insufficiency 56 32 frequent (33%) Frequent (79-30%) HP:0002093
13 abdominal pain 56 32 frequent (33%) Frequent (79-30%) HP:0002027
14 hypoproteinemia 56 32 frequent (33%) Frequent (79-30%) HP:0003075
15 conjunctivitis 56 32 frequent (33%) Frequent (79-30%) HP:0000509
16 atelectasis 56 32 frequent (33%) Frequent (79-30%) HP:0100750
17 hemoptysis 56 32 occasional (7.5%) Occasional (29-5%) HP:0002105
18 hypotension 56 32 occasional (7.5%) Occasional (29-5%) HP:0002615
19 arthralgia 56 32 frequent (33%) Frequent (79-30%) HP:0002829
20 pleural effusion 56 32 frequent (33%) Frequent (79-30%) HP:0002202
21 pulmonary infiltrates 56 32 frequent (33%) Frequent (79-30%) HP:0002113
22 leukocytosis 56 32 frequent (33%) Frequent (79-30%) HP:0001974
23 intracranial hemorrhage 56 32 occasional (7.5%) Occasional (29-5%) HP:0002170
24 elevated hepatic transaminases 56 32 frequent (33%) Frequent (79-30%) HP:0002910
25 gastrointestinal hemorrhage 56 32 occasional (7.5%) Occasional (29-5%) HP:0002239
26 tubulointerstitial abnormality 56 32 frequent (33%) Frequent (79-30%) HP:0001969
27 amaurosis fugax 56 32 occasional (7.5%) Occasional (29-5%) HP:0100576
28 abnormality of the myocardium 56 32 occasional (7.5%) Occasional (29-5%) HP:0001637
29 abnormality of the pericardium 56 32 occasional (7.5%) Occasional (29-5%) HP:0001697
30 oliguria 56 32 frequent (33%) Frequent (79-30%) HP:0100520
31 subconjunctival hemorrhage 56 32 frequent (33%) Frequent (79-30%) HP:0011896
32 abnormality of the renal tubule 56 Frequent (79-30%)

MGI Mouse Phenotypes related to Hemorrhagic Fever with Renal Syndrome:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.09 B2M CD163 CD40LG CRP IL10 IL6
2 homeostasis/metabolism MP:0005376 10.06 ALB B2M CD163 CD40LG CRP IL10
3 hematopoietic system MP:0005397 10.02 B2M CD163 CD40LG IL10 IL6 ITGB3
4 immune system MP:0005387 9.91 TNF B2M CD163 CD40LG CRP IL10
5 digestive/alimentary MP:0005381 9.88 ALB B2M IL10 IL6 ITGB3 TNF
6 liver/biliary system MP:0005370 9.63 IL10 IL6 ITGB3 TNF ALB B2M
7 neoplasm MP:0002006 9.43 ALB B2M IL10 IL6 ITGB3 TNF
8 skeleton MP:0005390 9.17 CD40LG HLA-DRB5 IL10 IL6 ITGB3 SEMA4D

Drugs & Therapeutics for Hemorrhagic Fever with Renal Syndrome

Drugs for Hemorrhagic Fever with Renal Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibodies Phase 3
2 Antibodies, Blocking Phase 3
3 Immunoglobulins Phase 3
4 Vaccines Phase 3,Phase 2,Phase 1
5
Epinephrine Approved, Vet_approved Phase 2,Phase 1 51-43-4 5816
6 Racepinephrine Approved Phase 2,Phase 1
7
Ribavirin Approved Phase 2 36791-04-5 37542
8 Epinephryl borate Phase 2,Phase 1
9 Anti-Infective Agents Phase 2
10 Antimetabolites Phase 2
11 Antiviral Agents Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Study to Evalutate Long-term Immunity of Hantavax in High Risk Population of HFRS Completed NCT02360514 Phase 3 Hantavax injection
2 Phase 2a Immunogenicity Study of Hantaan/Puumala Virus DNA Vaccine for Prevention of Hemorrhagic Fever Active, not recruiting NCT02116205 Phase 2
3 Ribavirin for Hemorrhagic Fever With Renal Syndrome Enrolling by invitation NCT00623168 Phase 2 Ribavirin
4 Ribavirin for Hemorrhagic Fever With Renal Syndrome in Germany Withdrawn NCT00868946 Phase 2 Virazole (Ribavirin)
5 Study to Evaluate the Safety, Tolerability, and Immunogenicity of Hantaan and Puumala Virus DNA Vaccines Completed NCT01502345 Phase 1
6 Diagnostic of Puumala Virus Infection in France Recruiting NCT02455375

Search NIH Clinical Center for Hemorrhagic Fever with Renal Syndrome

Cochrane evidence based reviews: hemorrhagic fever with renal syndrome

Genetic Tests for Hemorrhagic Fever with Renal Syndrome

Anatomical Context for Hemorrhagic Fever with Renal Syndrome

MalaCards organs/tissues related to Hemorrhagic Fever with Renal Syndrome:

39
Kidney, T Cells, Testes, Skin, Endothelial, B Cells, Neutrophil

Publications for Hemorrhagic Fever with Renal Syndrome

Articles related to Hemorrhagic Fever with Renal Syndrome:

(show top 50) (show all 381)
id Title Authors Year
1
Hemorrhagic fever with renal syndrome caused by Hantaan virus infection in four pregnant Chinese women. ( 28504470 )
2017
2
Performance assessment of the SAPS II and SOFA scoring systems in Hanta virus Hemorrhagic Fever with Renal Syndrome. ( 28804005 )
2017
3
Anthropogenically driven environmental changes shift the ecological dynamics of hemorrhagic fever with renal syndrome. ( 28141833 )
2017
4
Lack of association between integrin I+vI^3 gene polymorphisms and hemorrhagic fever with renal syndrome in Han Chinese from Hubei, China. ( 28190175 )
2017
5
Hantavirus retinitis and concurrent hemorrhagic fever with renal syndrome. ( 28237172 )
2017
6
Serum Cytokine Profiles Differentiating Hemorrhagic Fever with Renal Syndrome and Hantavirus Pulmonary Syndrome. ( 28572804 )
2017
7
Hemorrhagic fever with renal syndrome in Albania. Focus on predictors of acute kidney injury in HFRS. ( 28411480 )
2017
8
The influence of climatic factors on the development of hemorrhagic fever with renal syndrome and leptospirosis during the peak season in Korea: an ecologic study. ( 28592316 )
2017
9
Analysis of hemorrhagic fever with renal syndrome and its pathogenic gene sequence based on geographic information system. ( 28685549 )
2017
10
Corrigendum: Hemorrhagic Fever with Renal Syndrome: Pathogenesis and Clinical Picture. ( 27981038 )
2016
11
Time Series Analysis of Hemorrhagic Fever with Renal Syndrome: A Case Study in Jiaonan County, China. ( 27706256 )
2016
12
Cytokine response to Hantaan virus infection in patients with hemorrhagic fever with renal syndrome. ( 27943332 )
2016
13
Hemorrhagic Fever with Renal Syndrome: Pathogenesis and Clinical Picture. ( 26870699 )
2016
14
Effects of Humidity Variation on the Hantavirus Infection and Hemorrhagic Fever with Renal Syndrome Occurrence in Subtropical China. ( 26711521 )
2016
15
Molecular Diagnosis of Hemorrhagic Fever with Renal Syndrome Caused by Puumala Virus. ( 26962084 )
2016
16
Interferon-Induced Transmembrane Protein 3 Inhibits Hantaan Virus Infection, and Its Single Nucleotide Polymorphism rs12252 Influences the Severity of Hemorrhagic Fever with Renal Syndrome. ( 28096800 )
2016
17
Genovariation Study of Hantavirus in Main Endemic Areas of Hemorrhagic Fever with Renal Syndrome in Hebei Province, China. ( 27442527 )
2016
18
Prevalence of hemorrhagic fever with renal syndrome in Yiyuan County, China, 2005-2014. ( 26852019 )
2016
19
The assessment of Hantaan virus-specific antibody responses after the immunization program for hemorrhagic fever with renal syndrome in northwest China. ( 27824286 )
2016
20
Clinical characterization of two severe cases of hemorrhagic fever with renal syndrome (HFRS) caused by hantaviruses Puumala and Dobrava-Belgrade genotype Sochi. ( 27842513 )
2016
21
Changes in Plasma Adiponectin Concentrations in Patients With Hemorrhagic Fever With Renal Syndrome: An Observational Prospective Study. ( 26871804 )
2016
22
Prevalence of hemorrhagic fever with renal syndrome in Qingdao City, China, 2010-2014. ( 27786303 )
2016
23
Phylogeographic analysis of hemorrhagic fever with renal syndrome patients using multiplex PCR-based next generation sequencing. ( 27221218 )
2016
24
Epidemiological analysis of hemorrhagic fever with renal syndrome in China with the seasonal-trend decomposition method and the exponential smoothing model. ( 27976704 )
2016
25
History of incomplete vaccination may associate with occurrence of hemorrhagic fever with renal syndrome with relieved clinical symptoms. ( 26636561 )
2016
26
Spatio-Temporal Pattern and Influencing Factors of Hemorrhagic Fever with Renal Syndrome (HFRS) in Hubei Province (China) between 2005 and 2014. ( 28030550 )
2016
27
Hemorrhagic Fever with Renal Syndrome, Zibo City, China, 2006-2014. ( 26812444 )
2016
28
Construction of a Seasonal Difference-Geographically and Temporally Weighted Regression (SD-GTWR) Model and Comparative Analysis with GWR-Based Models for Hemorrhagic Fever with Renal Syndrome (HFRS) in Hubei Province (China). ( 27801870 )
2016
29
Acalculous cholecystitis associated with hemorrhagic fever with renal syndrome: a case report. ( 25982259 )
2015
30
Long-term persistence of anti-hantavirus antibodies in sera of patients undergoing hemorrhagic fever with renal syndrome and subjects vaccinated against the disease. ( 26654580 )
2015
31
Comparison of Two Hybrid Models for Forecasting the Incidence of Hemorrhagic Fever with Renal Syndrome in Jiangsu Province, China. ( 26270814 )
2015
32
Acalculous cholecystitis and hemorrhagic fever with renal syndrome. ( 26790561 )
2015
33
Puumala Hantavirus-Induced Hemorrhagic Fever with Renal Syndrome Must Be Considered across the Borders of Nephrology to Avoid Unnecessary Diagnostic Procedures. ( 26650941 )
2015
34
Modeling and predicting hemorrhagic Fever with renal syndrome trends based on meteorological factors in hu county, china. ( 25875211 )
2015
35
Letter on the article "An hemorrhagic fever with renal syndrome revealing a leptospirosis". ( 26160283 )
2015
36
Effects of Climate and Rodent Factors on Hemorrhagic Fever with Renal Syndrome in Chongqing, China, 1997-2008. ( 26193359 )
2015
37
Community Acquired Severe Acute Kidney Injury Caused by Hantavirus-Induced Hemorrhagic Fever with Renal Syndrome Has a Favorable Outcome. ( 26139246 )
2015
38
Elevated serum levels of decoy receptor 3 are associated with disease severity in patients with hemorrhagic fever with renal syndrome. ( 25647584 )
2015
39
Changes in rodent abundance and weather conditions potentially drive hemorrhagic fever with renal syndrome outbreaks in Xi'an, China, 2005-2012. ( 25822936 )
2015
40
Correction: Spatiotemporal Transmission Dynamics of Hemorrhagic Fever with Renal Syndrome in China, 2005-2012. ( 25799067 )
2015
41
Acalculous cholecystitis and hemorrhagic fever with renal syndrome. ( 26139306 )
2015
42
Using autoregressive integrated moving average model to predict the incidence of hemorrhagic fever with renal syndrome in Zibo, China, 2004-2014. ( 26370428 )
2015
43
Hemorrhagic fever with renal syndrome-related encephalopathy: magnetic resonance imaging findings. ( 26362353 )
2015
44
HMGB-1 as a novel predictor of disease severity and prognosis in patients with hemorrhagic fever with renal syndrome. ( 25944988 )
2015
45
Upregulation of IFN-I^ and IL-12 is associated with a milder form of hantavirus hemorrhagic fever with renal syndrome. ( 24942310 )
2014
46
Hemorrhagic Fever with Renal Syndrome in the New, and Hantavirus Pulmonary Syndrome in the Old World: paradi(se)gm lost or regained? ( 24440318 )
2014
47
Clinical study of critical patients with hemorrhagic fever with renal syndrome complicated by acute respiratory distress syndrome. ( 24587001 )
2014
48
Epidemic characteristics of hemorrhagic fever with renal syndrome in China, 2006-2012. ( 25012160 )
2014
49
Proliferation and local manifestations of oxidative stress in mucous membrane of the ileum in patients at early stages of hemorrhagic fever with renal syndrome. ( 24771366 )
2014
50
Analysis of an outbreak of hemorrhagic fever with renal syndrome in college students in Xi'an, China. ( 24481251 )
2014

Variations for Hemorrhagic Fever with Renal Syndrome

Expression for Hemorrhagic Fever with Renal Syndrome

Search GEO for disease gene expression data for Hemorrhagic Fever with Renal Syndrome.

Pathways for Hemorrhagic Fever with Renal Syndrome

Pathways related to Hemorrhagic Fever with Renal Syndrome according to GeneCards Suite gene sharing:

(show all 31)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.89 B2M CD40LG CRP HLA-DRB1 HLA-DRB5 IL10
2
Show member pathways
13.19 B2M CD40LG HLA-DRB1 HLA-DRB5 IL10 IL6
3
Show member pathways
12.51 CD40LG HLA-DRB1 HLA-DRB5 IL10 TNF
4
Show member pathways
12.46 HLA-DRB1 HLA-DRB5 IL10 IL6 TNF
5
Show member pathways
12.44 B2M CD40LG HLA-DRB1 HLA-DRB5 IL10 IL6
6 12.43 B2M CD40LG IL10 TNF
7
Show member pathways
12.34 CD40LG IL10 IL6 TNF
8 12.33 HLA-DRB1 HLA-DRB5 IL6 TNF
9
Show member pathways
12.07 CD40LG HLA-DRB1 HLA-DRB5 IL10 TNF
10
Show member pathways
12.04 IL10 IL6 TNF
11 12.02 HLA-DRB1 HLA-DRB5 IL10 IL6 TNF
12 11.88 IL10 IL6 TNF
13
Show member pathways
11.85 IL10 IL6 TNF
14 11.79 IL10 IL6 TNF
15 11.77 HLA-DRB1 HLA-DRB5 IL6 TNF
16 11.72 CD163 IL10 IL6 ITGB3 TNF
17 11.68 IL10 IL6 TNF
18 11.64 CD163 IL10 IL6 TNF
19 11.59 CD40LG IL10 ITGB3
20
Show member pathways
11.58 CD40LG IL6 TNF
21 11.58 CD40LG IL10 IL6 TNF
22 11.52 HLA-DRB1 HLA-DRB5 IL10
23 11.44 IL10 IL6 TNF
24 11.42 IL6 TNF VTN
25 11.31 CD40LG IL10 IL6 TNF
26 11.27 IL10 IL6 TNF
27 11.26 IL10 IL6 TNF
28 11.12 CD40LG IL10 IL6 TNF
29 11.01 HLA-DRB1 HLA-DRB5 IL6 ITGB3 TNF
30 10.95 CRP IL6 TNF
31 10.73 HLA-DRB1 IL10 IL6 TNF

GO Terms for Hemorrhagic Fever with Renal Syndrome

Cellular components related to Hemorrhagic Fever with Renal Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.81 ALB B2M CD163 CD40LG CRP IL10
2 cell surface GO:0009986 9.8 B2M CD40LG HLA-DRB1 ITGB3 TNF
3 extracellular space GO:0005615 9.61 ALB B2M CD40LG CRP IL10 IL6
4 endocytic vesicle membrane GO:0030666 9.54 CD163 HLA-DRB1 HLA-DRB5
5 ER to Golgi transport vesicle membrane GO:0012507 9.5 B2M HLA-DRB1 HLA-DRB5
6 MHC class II protein complex GO:0042613 9.43 HLA-DRB1 HLA-DRB5
7 alphav-beta3 integrin-vitronectin complex GO:0071062 9.26 ITGB3 VTN
8 external side of plasma membrane GO:0009897 9.1 B2M CD163 CD40LG HLA-DRB1 IL6 TNF

Biological processes related to Hemorrhagic Fever with Renal Syndrome according to GeneCards Suite gene sharing:

(show all 30)
id Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.89 ALB CD40LG IL10 IL6 SEMA4D
2 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.82 CD40LG IL6 TNF
3 cellular response to lipopolysaccharide GO:0071222 9.81 IL10 IL6 TNF
4 platelet activation GO:0030168 9.79 CD40LG IL6 ITGB3
5 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.78 IL10 IL6 TNF
6 defense response to Gram-positive bacterium GO:0050830 9.73 CRP IL6 TNF
7 T cell costimulation GO:0031295 9.72 CD40LG HLA-DRB1 HLA-DRB5
8 interferon-gamma-mediated signaling pathway GO:0060333 9.7 B2M HLA-DRB1 HLA-DRB5
9 response to glucocorticoid GO:0051384 9.69 IL10 IL6 TNF
10 positive regulation of receptor-mediated endocytosis GO:0048260 9.64 B2M VTN
11 cell adhesion mediated by integrin GO:0033627 9.63 ITGB3 VTN
12 positive regulation of chemokine production GO:0032722 9.63 IL6 TNF
13 inflammatory response GO:0006954 9.63 CD163 CD40LG CRP IL10 IL6 TNF
14 negative regulation of growth of symbiont in host GO:0044130 9.62 IL10 TNF
15 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.61 ITGB3 VTN
16 cellular response to hepatocyte growth factor stimulus GO:0035729 9.6 IL10 IL6
17 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.59 HLA-DRB1 HLA-DRB5
18 negative regulation of macrophage derived foam cell differentiation GO:0010745 9.58 CRP ITGB3
19 response to molecule of bacterial origin GO:0002237 9.58 B2M IL10
20 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.57 IL10 TNF
21 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.56 IL6 ITGB3 SEMA4D VTN
22 endothelial cell apoptotic process GO:0072577 9.54 IL10 TNF
23 acute-phase response GO:0006953 9.5 CD163 CRP IL6
24 negative regulation of cytokine secretion involved in immune response GO:0002740 9.48 IL10 TNF
25 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.46 IL6 TNF
26 regulation of immunoglobulin secretion GO:0051023 9.43 CD40LG TNF
27 receptor biosynthetic process GO:0032800 9.4 IL10 TNF
28 negative regulation of alkaline phosphatase activity GO:0010693 9.37 SEMA4D TNF
29 immune response GO:0006955 9.28 B2M CD40LG HLA-DRB1 HLA-DRB5 IL10 IL6
30 negative regulation of lipid storage GO:0010888 9.26 CRP IL6 ITGB3 TNF

Molecular functions related to Hemorrhagic Fever with Renal Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 CD40LG IL10 IL6 TNF

Sources for Hemorrhagic Fever with Renal Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
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48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
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67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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