MCID: HMR004
MIFTS: 63

Hemorrhagic Fever with Renal Syndrome

Categories: Nephrological diseases, Infectious diseases, Rare diseases

Aliases & Classifications for Hemorrhagic Fever with Renal Syndrome

MalaCards integrated aliases for Hemorrhagic Fever with Renal Syndrome:

Name: Hemorrhagic Fever with Renal Syndrome 12 72 41 14 69
Hantavirosis 55 69
Hemorrhagic Fever-Renal Syndrome 55
Hemorrhagic Nephrosonephritis 12
Hemorrhagic Fever, Russian 12
Puumala Virus Nephropathy 12
Hantavirus Fever 55
Hfrs 12

Characteristics:

Orphanet epidemiological data:

55
hemorrhagic fever-renal syndrome
Prevalence: 1-9/1000000 (Europe); Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 55  
Rare infectious diseases


Summaries for Hemorrhagic Fever with Renal Syndrome

Disease Ontology : 12 A viral infectious disease that is a hemorrhagic fever, located in kidney, has material basis in Hantaan virus, has material basis in Dobrava-Belgrade virus, has material basis in Seoul virus, or has material basis in Puumala virus, which are carried and transmitted_by rodents. The infection has symptom headache, has symptom fever, has symptom muscle pains, has symptom facial flush, has symptom petechiae, has symptom hemorrhagic features, has symptom proteinuria, and has symptom renal failure.

MalaCards based summary : Hemorrhagic Fever with Renal Syndrome, also known as hantavirosis, is related to acalculous cholecystitis and hemorrhagic fever, and has symptoms including headache, fever and muscle pains. An important gene associated with Hemorrhagic Fever with Renal Syndrome is CD40LG (CD40 Ligand), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Antibodies and Antibodies, Blocking have been mentioned in the context of this disorder. Affiliated tissues include kidney, kidney and t cells, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 72 Hantavirus hemorrhagic fever with renal syndrome (HFRS) is a group of clinically similar illnesses... more...

Related Diseases for Hemorrhagic Fever with Renal Syndrome

Diseases related to Hemorrhagic Fever with Renal Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 304)
# Related Disease Score Top Affiliating Genes
1 acalculous cholecystitis 30.7 CD40LG CRP
2 hemorrhagic fever 30.5 ALB CD40LG HLA-DRB1 IL10 IL6 TNF
3 acute pancreatitis 30.2 CRP IL10 IL6
4 hemophagocytic lymphohistiocytosis 29.9 B2M IL10 TNF
5 scrub typhus 29.5 CD40LG CRP IL10 TNF
6 leptospirosis 29.5 CD40LG CRP IL10 IL6 TNF
7 chlamydia 29.2 CD40LG CRP IL10 IL6 TNF
8 peritonitis 28.7 ALB B2M CRP IL10 IL6 TNF
9 myocardial infarction 28.3 ALB CD40LG CRP IL10 IL6 ITGB3
10 korean hemorrhagic fever 11.9
11 danubian endemic familial nephropathy 11.4
12 hantavirus pulmonary syndrome 11.4
13 pancreatitis, hereditary 11.0
14 balkan hemorrhagic fever 11.0
15 scorpion envenomation 10.6 IL6 TNF
16 angioimmunoblastic lymphadenopathy with dysproteinemia 10.5 IL6 TNF
17 critical limb ischemia 10.5 IL6 TNF
18 sudden sensorineural hearing loss 10.5 IL6 ITGB3
19 extramedullary plasmacytoma 10.5 B2M IL6
20 streptococcal toxic-shock syndrome 10.5 IL6 TNF
21 cold agglutinin disease 10.5 CRP IL6
22 null-cell leukemia 10.5 IL6 TNF
23 trench fever 10.5 CD40LG TNF
24 encephalitozoonosis 10.5 CD40LG TNF
25 rheumatoid lung disease 10.5 CD40LG TNF
26 miller fisher syndrome 10.5 CD40LG TNF
27 diabetic foot ulcers 10.5 CRP IL6
28 cryopyrin-associated periodic syndrome 10.5 CRP IL6
29 neutrophilia, hereditary 10.5 CRP IL6
30 acute cholangitis 10.5 CRP IL6
31 retinitis pigmentosa 55 10.5 IL6 TNF
32 cardiogenic shock 10.4 CRP IL6
33 mononeuritis multiplex 10.4 CD40LG CRP
34 glossitis 10.4 IL6 TNF
35 polyclonal hypergammaglobulinemia 10.4 CD40LG IL6
36 aids dementia complex 10.4 B2M TNF
37 beryllium disease 10.4 HLA-DRB1 TNF
38 laryngitis 10.4 IL6 TNF
39 punctate inner choroidopathy 10.4 IL10 TNF
40 tropical endomyocardial fibrosis 10.4 IL10 TNF
41 uremic pruritus 10.4 CRP IL6
42 immunodeficiency 43 10.4 ALB B2M
43 melancholia 10.4 CRP TNF
44 spinal disease 10.4 CRP IL6
45 plasma cell neoplasm 10.4 B2M CD40LG IL6
46 osteosclerotic myeloma 10.4 CD40LG IL6 TNF
47 chronic beryllium disease 10.4 HLA-DRB1 TNF
48 acute maxillary sinusitis 10.4 CD40LG CRP
49 multifocal choroiditis 10.4 IL10 TNF
50 colorado tick fever 10.4 ALB CD40LG

Graphical network of the top 20 diseases related to Hemorrhagic Fever with Renal Syndrome:



Diseases related to Hemorrhagic Fever with Renal Syndrome

Symptoms & Phenotypes for Hemorrhagic Fever with Renal Syndrome

Symptoms:

12
  • headache
  • fever
  • muscle pains
  • facial flush
  • petechiae
  • hemorrhagic features
  • proteinuria
  • renal failure

Human phenotypes related to Hemorrhagic Fever with Renal Syndrome:

55 31 (show all 34)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 renal insufficiency 55 31 frequent (33%) Frequent (79-30%) HP:0000083
2 proteinuria 55 31 frequent (33%) Frequent (79-30%) HP:0000093
3 conjunctivitis 55 31 frequent (33%) Frequent (79-30%) HP:0000509
4 myopia 55 31 occasional (7.5%) Occasional (29-5%) HP:0000545
5 photophobia 55 31 frequent (33%) Frequent (79-30%) HP:0000613
6 hypertension 55 31 occasional (7.5%) Occasional (29-5%) HP:0000822
7 thrombocytopenia 55 31 frequent (33%) Frequent (79-30%) HP:0001873
8 fever 55 31 hallmark (90%) Very frequent (99-80%) HP:0001945
9 tubulointerstitial abnormality 55 31 frequent (33%) Frequent (79-30%) HP:0001969
10 leukocytosis 55 31 frequent (33%) Frequent (79-30%) HP:0001974
11 abdominal pain 55 31 frequent (33%) Frequent (79-30%) HP:0002027
12 migraine 55 31 frequent (33%) Frequent (79-30%) HP:0002076
13 respiratory insufficiency 55 31 frequent (33%) Frequent (79-30%) HP:0002093
14 hemoptysis 55 31 occasional (7.5%) Occasional (29-5%) HP:0002105
15 pulmonary infiltrates 55 31 frequent (33%) Frequent (79-30%) HP:0002113
16 intracranial hemorrhage 55 31 occasional (7.5%) Occasional (29-5%) HP:0002170
17 pleural effusion 55 31 frequent (33%) Frequent (79-30%) HP:0002202
18 gastrointestinal hemorrhage 55 31 occasional (7.5%) Occasional (29-5%) HP:0002239
19 hypotension 55 31 occasional (7.5%) Occasional (29-5%) HP:0002615
20 arthralgia 55 31 frequent (33%) Frequent (79-30%) HP:0002829
21 elevated hepatic transaminases 55 31 frequent (33%) Frequent (79-30%) HP:0002910
22 hypoproteinemia 55 31 frequent (33%) Frequent (79-30%) HP:0003075
23 myalgia 55 31 frequent (33%) Frequent (79-30%) HP:0003326
24 arrhythmia 55 31 occasional (7.5%) Occasional (29-5%) HP:0011675
25 subconjunctival hemorrhage 55 31 frequent (33%) Frequent (79-30%) HP:0011896
26 fatigue 55 31 hallmark (90%) Very frequent (99-80%) HP:0012378
27 oliguria 55 31 frequent (33%) Frequent (79-30%) HP:0100520
28 amaurosis fugax 55 31 occasional (7.5%) Occasional (29-5%) HP:0100576
29 atelectasis 55 31 frequent (33%) Frequent (79-30%) HP:0100750
30 abnormality of the renal tubule 55 Frequent (79-30%)
31 abnormality of the myocardium 55 Occasional (29-5%)
32 abnormality of the pericardium 55 Occasional (29-5%)
33 abnormal myocardium morphology 31 occasional (7.5%) HP:0001637
34 abnormal pericardium morphology 31 occasional (7.5%) HP:0001697

MGI Mouse Phenotypes related to Hemorrhagic Fever with Renal Syndrome:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.11 CD40LG ITGB3 SEMA4D CRP TNF IL10
2 homeostasis/metabolism MP:0005376 10.11 CD40LG ITGB3 SEMA4D CRP TNF ALB
3 hematopoietic system MP:0005397 10.1 CD40LG ITGB3 TNF HLA-DRB5 SEMA4D IL10
4 immune system MP:0005387 10.02 CD40LG ITGB3 SEMA4D CRP TNF HLA-DRB5
5 digestive/alimentary MP:0005381 9.91 ITGB3 TNF ALB IL10 B2M IL6
6 liver/biliary system MP:0005370 9.73 ITGB3 TNF ALB IL10 B2M IL6
7 muscle MP:0005369 9.63 CD163 IL6 ITGB3 TNF ALB IL10
8 neoplasm MP:0002006 9.43 ITGB3 TNF ALB IL10 B2M IL6
9 skeleton MP:0005390 9.17 IL6 CD40LG SEMA4D ITGB3 HLA-DRB5 TNF

Drugs & Therapeutics for Hemorrhagic Fever with Renal Syndrome

Drugs for Hemorrhagic Fever with Renal Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibodies Phase 3
2 Antibodies, Blocking Phase 3
3 Immunoglobulins Phase 3
4 Vaccines Phase 3,Phase 2,Phase 1
5
Epinephrine Approved, Vet_approved Phase 2,Phase 1 51-43-4 5816
6 Racepinephrine Approved Phase 2,Phase 1 329-65-7
7
Ribavirin Approved Phase 2 36791-04-5 37542
8 Epinephryl borate Phase 2,Phase 1
9 Anti-Infective Agents Phase 2
10 Antimetabolites Phase 2
11 Antiviral Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study to Evalutate Long-term Immunity of Hantavax in High Risk Population of HFRS Completed NCT02360514 Phase 3 Hantavax injection
2 Phase 2a Immunogenicity Study of Hantaan/Puumala Virus DNA Vaccine for Prevention of Hemorrhagic Fever Active, not recruiting NCT02116205 Phase 2
3 Ribavirin for Hemorrhagic Fever With Renal Syndrome Enrolling by invitation NCT00623168 Phase 2 Ribavirin
4 Ribavirin for Hemorrhagic Fever With Renal Syndrome in Germany Withdrawn NCT00868946 Phase 2 Virazole (Ribavirin)
5 Study to Evaluate the Safety, Tolerability, and Immunogenicity of Hantaan and Puumala Virus DNA Vaccines Completed NCT01502345 Phase 1
6 Diagnostic of Puumala Virus Infection in France Recruiting NCT02455375

Search NIH Clinical Center for Hemorrhagic Fever with Renal Syndrome

Cochrane evidence based reviews: hemorrhagic fever with renal syndrome

Genetic Tests for Hemorrhagic Fever with Renal Syndrome

Anatomical Context for Hemorrhagic Fever with Renal Syndrome

The Foundational Model of Anatomy Ontology organs/tissues related to Hemorrhagic Fever with Renal Syndrome:

18
Kidney

MalaCards organs/tissues related to Hemorrhagic Fever with Renal Syndrome:

38
Kidney, T Cells, Testes, B Cells, Endothelial, Neutrophil, Pancreas

Publications for Hemorrhagic Fever with Renal Syndrome

Articles related to Hemorrhagic Fever with Renal Syndrome:

(show top 50) (show all 388)
# Title Authors Year
1
Differential Regulation of PAI-1 in Hantavirus Cardiopulmonary Syndrome and Hemorrhagic Fever With Renal Syndrome. ( 29450213 )
2018
2
Protective effectiveness of inactivated hantavirus vaccine against hemorrhagic fever with renal syndrome. ( 29373686 )
2018
3
Risk of Venous Thromboembolism Following Hemorrhagic Fever With Renal Syndrome: A Self-controlled Case Series Study. ( 29020303 )
2018
4
Landscape and rodent community composition are associated with risk of hemorrhagic fever with renal syndrome in two cities in China, 2006-2013. ( 29329512 )
2018
5
Mapping the epidemic changes and risks of hemorrhagic fever with renal syndrome in Shaanxi Province, China, 2005-2016. ( 29335595 )
2018
6
Analysis of hemorrhagic fever with renal syndrome and its pathogenic gene sequence based on geographic information system. ( 28685549 )
2017
7
Lack of association between integrin I+vI^3 gene polymorphisms and hemorrhagic fever with renal syndrome in Han Chinese from Hubei, China. ( 28190175 )
2017
8
Novel Identified HLA-A*0201-Restricted Hantaan Virus Glycoprotein Cytotoxic T-Cell Epitopes Could Effectively Induce Protective Responses in HLA-A2.1/K<sup>b</sup>Transgenic Mice May Associate with the Severity of Hemorrhagic Fever with Renal Syndrome. ( 29312318 )
2017
9
Hantavirus retinitis and concurrent hemorrhagic fever with renal syndrome. ( 28237172 )
2017
10
Hemorrhagic fever with renal syndrome in Albania. Focus on predictors of acute kidney injury in HFRS. ( 28411480 )
2017
11
Serum Cytokine Profiles Differentiating Hemorrhagic Fever with Renal Syndrome and Hantavirus Pulmonary Syndrome. ( 28572804 )
2017
12
Anthropogenically driven environmental changes shift the ecological dynamics of hemorrhagic fever with renal syndrome. ( 28141833 )
2017
13
Hemorrhagic fever with renal syndrome caused by Hantaan virus infection in four pregnant Chinese women. ( 28504470 )
2017
14
The influence of climatic factors on the development of hemorrhagic fever with renal syndrome and leptospirosis during the peak season in Korea: an ecologic study. ( 28592316 )
2017
15
Meteorological factors affect the epidemiology of hemorrhagic fever with renal syndrome via altering the breeding and hantavirus-carrying states of rodents and mites: a 9 years' longitudinal study. ( 29184158 )
2017
16
Performance assessment of the SAPS II and SOFA scoring systems in Hanta virus Hemorrhagic Fever with Renal Syndrome. ( 28804005 )
2017
17
Genovariation Study of Hantavirus in Main Endemic Areas of Hemorrhagic Fever with Renal Syndrome in Hebei Province, China. ( 27442527 )
2016
18
The assessment of Hantaan virus-specific antibody responses after the immunization program for hemorrhagic fever with renal syndrome in northwest China. ( 27824286 )
2016
19
Prevalence of hemorrhagic fever with renal syndrome in Qingdao City, China, 2010-2014. ( 27786303 )
2016
20
Clinical characterization of two severe cases of hemorrhagic fever with renal syndrome (HFRS) caused by hantaviruses Puumala and Dobrava-Belgrade genotype Sochi. ( 27842513 )
2016
21
Phylogeographic analysis of hemorrhagic fever with renal syndrome patients using multiplex PCR-based next generation sequencing. ( 27221218 )
2016
22
Epidemiological analysis of hemorrhagic fever with renal syndrome in China with the seasonal-trend decomposition method and the exponential smoothing model. ( 27976704 )
2016
23
Interferon-Induced Transmembrane Protein 3 Inhibits Hantaan Virus Infection, and Its Single Nucleotide Polymorphism rs12252 Influences the Severity of Hemorrhagic Fever with Renal Syndrome. ( 28096800 )
2016
24
Construction of a Seasonal Difference-Geographically and Temporally Weighted Regression (SD-GTWR) Model and Comparative Analysis with GWR-Based Models for Hemorrhagic Fever with Renal Syndrome (HFRS) in Hubei Province (China). ( 27801870 )
2016
25
Molecular Diagnosis of Hemorrhagic Fever with Renal Syndrome Caused by Puumala Virus. ( 26962084 )
2016
26
Prevalence of hemorrhagic fever with renal syndrome in Yiyuan County, China, 2005-2014. ( 26852019 )
2016
27
History of incomplete vaccination may associate with occurrence of hemorrhagic fever with renal syndrome with relieved clinical symptoms. ( 26636561 )
2016
28
Hemorrhagic Fever with Renal Syndrome, Zibo City, China, 2006-2014. ( 26812444 )
2016
29
Effects of Humidity Variation on the Hantavirus Infection and Hemorrhagic Fever with Renal Syndrome Occurrence in Subtropical China. ( 26711521 )
2016
30
Hemorrhagic Fever with Renal Syndrome: Pathogenesis and Clinical Picture. ( 26870699 )
2016
31
Cytokine response to Hantaan virus infection in patients with hemorrhagic fever with renal syndrome. ( 27943332 )
2016
32
Spatio-Temporal Pattern and Influencing Factors of Hemorrhagic Fever with Renal Syndrome (HFRS) in Hubei Province (China) between 2005 and 2014. ( 28030550 )
2016
33
Corrigendum: Hemorrhagic Fever with Renal Syndrome: Pathogenesis and Clinical Picture. ( 27981038 )
2016
34
Time Series Analysis of Hemorrhagic Fever with Renal Syndrome: A Case Study in Jiaonan County, China. ( 27706256 )
2016
35
Changes in Plasma Adiponectin Concentrations in Patients With Hemorrhagic Fever With Renal Syndrome: An Observational Prospective Study. ( 26871804 )
2016
36
Letter on the article "An hemorrhagic fever with renal syndrome revealing a leptospirosis". ( 26160283 )
2015
37
Acalculous cholecystitis and hemorrhagic fever with renal syndrome. ( 26139306 )
2015
38
Acalculous cholecystitis associated with hemorrhagic fever with renal syndrome: a case report. ( 25982259 )
2015
39
Changes in rodent abundance and weather conditions potentially drive hemorrhagic fever with renal syndrome outbreaks in Xi'an, China, 2005-2012. ( 25822936 )
2015
40
Effects of Climate and Rodent Factors on Hemorrhagic Fever with Renal Syndrome in Chongqing, China, 1997-2008. ( 26193359 )
2015
41
Using autoregressive integrated moving average model to predict the incidence of hemorrhagic fever with renal syndrome in Zibo, China, 2004-2014. ( 26370428 )
2015
42
Comparison of Two Hybrid Models for Forecasting the Incidence of Hemorrhagic Fever with Renal Syndrome in Jiangsu Province, China. ( 26270814 )
2015
43
Modeling and predicting hemorrhagic Fever with renal syndrome trends based on meteorological factors in hu county, china. ( 25875211 )
2015
44
Puumala Hantavirus-Induced Hemorrhagic Fever with Renal Syndrome Must Be Considered across the Borders of Nephrology to Avoid Unnecessary Diagnostic Procedures. ( 26650941 )
2015
45
Correction: Spatiotemporal Transmission Dynamics of Hemorrhagic Fever with Renal Syndrome in China, 2005-2012. ( 25799067 )
2015
46
Acalculous cholecystitis and hemorrhagic fever with renal syndrome. ( 26790561 )
2015
47
Long-term persistence of anti-hantavirus antibodies in sera of patients undergoing hemorrhagic fever with renal syndrome and subjects vaccinated against the disease. ( 26654580 )
2015
48
HMGB-1 as a novel predictor of disease severity and prognosis in patients with hemorrhagic fever with renal syndrome. ( 25944988 )
2015
49
Hemorrhagic fever with renal syndrome-related encephalopathy: magnetic resonance imaging findings. ( 26362353 )
2015
50
Community Acquired Severe Acute Kidney Injury Caused by Hantavirus-Induced Hemorrhagic Fever with Renal Syndrome Has a Favorable Outcome. ( 26139246 )
2015

Variations for Hemorrhagic Fever with Renal Syndrome

Expression for Hemorrhagic Fever with Renal Syndrome

Search GEO for disease gene expression data for Hemorrhagic Fever with Renal Syndrome.

Pathways for Hemorrhagic Fever with Renal Syndrome

Pathways related to Hemorrhagic Fever with Renal Syndrome according to GeneCards Suite gene sharing:

(show all 33)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.89 B2M CD40LG CRP HLA-DRB1 HLA-DRB5 IL10
2
Show member pathways
13.19 B2M CD40LG HLA-DRB1 HLA-DRB5 IL10 IL6
3
Show member pathways
12.51 CD40LG HLA-DRB1 HLA-DRB5 IL10 TNF
4 12.46 B2M CD40LG IL10 TNF
5
Show member pathways
12.46 HLA-DRB1 HLA-DRB5 IL10 IL6 TNF
6
Show member pathways
12.44 B2M CD40LG HLA-DRB1 HLA-DRB5 IL10 IL6
7
Show member pathways
12.35 CD40LG IL10 IL6 TNF
8 12.34 HLA-DRB1 HLA-DRB5 IL6 TNF
9
Show member pathways
12.24 ALB CRP IL6 TNF
10
Show member pathways
12.07 CD40LG HLA-DRB1 HLA-DRB5 IL10 TNF
11
Show member pathways
12.04 IL10 IL6 TNF
12 12.02 HLA-DRB1 HLA-DRB5 IL10 IL6 TNF
13 11.89 IL10 IL6 TNF
14
Show member pathways
11.84 IL10 IL6 TNF
15 11.8 IL10 IL6 TNF
16 11.75 HLA-DRB1 HLA-DRB5 IL6 TNF
17 11.72 CD163 IL10 IL6 ITGB3 TNF
18 11.69 IL10 IL6 TNF
19 11.63 CD163 IL10 IL6 TNF
20 11.59 CD40LG IL10 ITGB3
21
Show member pathways
11.59 CD40LG IL6 TNF
22 11.55 CD40LG IL10 IL6 TNF
23 11.52 HLA-DRB1 HLA-DRB5 IL10
24 11.44 IL10 IL6 TNF
25 11.42 IL6 TNF VTN
26 11.31 CD40LG IL10 IL6 TNF
27 11.27 IL10 IL6 TNF
28 11.26 IL10 IL6 TNF
29 11.12 CD40LG IL10 IL6 TNF
30 11.01 HLA-DRB1 HLA-DRB5 IL6 ITGB3 TNF
31 10.97 CRP IL6 TNF
32 10.92 CD40LG IL10 IL6 ITGB3 TNF
33 10.73 HLA-DRB1 IL10 IL6 TNF

GO Terms for Hemorrhagic Fever with Renal Syndrome

Cellular components related to Hemorrhagic Fever with Renal Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.81 ALB B2M CD163 CD40LG CRP IL10
2 cell surface GO:0009986 9.8 B2M CD40LG HLA-DRB1 ITGB3 TNF
3 endocytic vesicle membrane GO:0030666 9.54 CD163 HLA-DRB1 HLA-DRB5
4 ER to Golgi transport vesicle membrane GO:0012507 9.5 B2M HLA-DRB1 HLA-DRB5
5 MHC class II protein complex GO:0042613 9.43 HLA-DRB1 HLA-DRB5
6 external side of plasma membrane GO:0009897 9.35 B2M CD163 CD40LG HLA-DRB1 TNF
7 extracellular space GO:0005615 9.28 ALB B2M CD40LG CRP IL10 IL6
8 alphav-beta3 integrin-vitronectin complex GO:0071062 9.26 ITGB3 VTN

Biological processes related to Hemorrhagic Fever with Renal Syndrome according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.89 ALB CD40LG IL10 IL6 SEMA4D
2 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.81 CD40LG IL6 TNF
3 cellular response to lipopolysaccharide GO:0071222 9.8 IL10 IL6 TNF
4 platelet activation GO:0030168 9.79 CD40LG IL6 ITGB3
5 positive regulation of DNA binding transcription factor activity GO:0051091 9.76 IL10 IL6 TNF
6 defense response to Gram-positive bacterium GO:0050830 9.72 CRP IL6 TNF
7 T cell costimulation GO:0031295 9.7 CD40LG HLA-DRB1 HLA-DRB5
8 interferon-gamma-mediated signaling pathway GO:0060333 9.69 B2M HLA-DRB1 HLA-DRB5
9 response to glucocorticoid GO:0051384 9.65 IL10 IL6 TNF
10 positive regulation of receptor-mediated endocytosis GO:0048260 9.64 B2M VTN
11 positive regulation of chemokine production GO:0032722 9.63 IL6 TNF
12 inflammatory response GO:0006954 9.63 CD163 CD40LG CRP IL10 IL6 TNF
13 cell adhesion mediated by integrin GO:0033627 9.62 ITGB3 VTN
14 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.61 ITGB3 VTN
15 negative regulation of growth of symbiont in host GO:0044130 9.6 IL10 TNF
16 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.59 HLA-DRB1 HLA-DRB5
17 negative regulation of macrophage derived foam cell differentiation GO:0010745 9.58 CRP ITGB3
18 response to molecule of bacterial origin GO:0002237 9.57 B2M IL10
19 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.56 IL10 TNF
20 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.56 IL6 ITGB3 SEMA4D VTN
21 endothelial cell apoptotic process GO:0072577 9.54 IL10 TNF
22 acute-phase response GO:0006953 9.5 CD163 CRP IL6
23 negative regulation of cytokine secretion involved in immune response GO:0002740 9.46 IL10 TNF
24 regulation of immunoglobulin secretion GO:0051023 9.43 CD40LG TNF
25 receptor biosynthetic process GO:0032800 9.4 IL10 TNF
26 negative regulation of alkaline phosphatase activity GO:0010693 9.37 SEMA4D TNF
27 immune response GO:0006955 9.28 B2M CD40LG HLA-DRB1 HLA-DRB5 IL10 IL6
28 negative regulation of lipid storage GO:0010888 9.26 CRP IL6 ITGB3 TNF

Molecular functions related to Hemorrhagic Fever with Renal Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.43 ALB B2M CRP ITGB3 TNF VTN
2 cytokine activity GO:0005125 8.92 CD40LG IL10 IL6 TNF

Sources for Hemorrhagic Fever with Renal Syndrome

3 CDC
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10 dbSNP
11 DGIdb
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