Aliases & Classifications for Hemosiderosis

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Hemosiderosis, Aliases & Descriptions:

Name: Hemosiderosis 9 41 11 43 60
 
Haemosiderosis 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


External Ids:

Disease Ontology9 DOID:12119
NCIt38 C82892
SNOMED-CT55 39011001, 190849009
MeSH33 D006486

Summaries for Hemosiderosis

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Disease Ontology:9 An iron metabolism disease that has material basis in an accumulation of hemosiderin, an iron-storage complex, resulting in iron overload.

MalaCards based summary: Hemosiderosis, also known as haemosiderosis, is related to hemochromatosis and hepatitis. An important gene associated with Hemosiderosis is CP (ceruloplasmin (ferroxidase)), and among its related pathways are Metal ion SLC transporters and HIF-2-alpha transcription factor network. The drug cyclophosphamide and the compounds ferric oxide and recormon have been mentioned in the context of this disorder. Affiliated tissues include liver, lung and heart, and related mouse phenotypes are liver/biliary system and immune system.

Wikipedia:63 Hemosiderosis (AmE) or haemosiderosis (BrE) is a form of iron overload disorder resulting in the... more...

Related Diseases for Hemosiderosis

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Diseases related to Hemosiderosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 157)
idRelated DiseaseScoreTop Affiliating Genes
1hemochromatosis31.1SLC11A2, HFE, CP, TF
2hepatitis31.1CP, CAT, HFE
3aceruloplasminemia30.8CP
4iron deficiency anemia30.6TF, EPO, HFE, SLC11A2
5hemolytic anemia30.4HFE, EPO, CP, TF
6porphyria30.4TF, HFE
7pneumoconiosis30.3CP, CAT
8sickle cell disease30.3EPO, TF
9tuberculosis30.3CP, MIF, SLC11A2
10liver cirrhosis30.2TF, CP, HFE
11microcytic anemia30.2TF, EPO, SLC11A2
12hepatitis c30.2SLC11A2, HFE, TF
13thalassemia30.1SLC11A2, HFE, FTH1, FTL, EPO, TF
14rheumatoid arthritis30.1HFE, MIF, CP
15siderosis29.9TF, CP, FTL, FTH1, HFE
16porphyria cutanea tarda29.8TF, FTL, FTH1, HFE
17arthritis29.7FTL, FTH1, MIF, CALCA, HFE
18vascular disease29.6TF, FTL, FTH1, CAT
19deficiency anemia29.5TF, CP, SLC11A2, HFE, MIF, FTH1
20hfe-associated hereditary hemochromatosis10.5HFE
21metanephric adenoma10.5KRT7
22brown induration10.5
23celiac disease10.4
24pityriasis versicolor10.4CAT
25bantu siderosis10.4HFE, TF
26iron metabolism disease10.4HFE, TF
27thalassemia, hispanic gamma-delta-beta10.4TF, HFE
28pancytopenia10.4EPO, CP
29alcohol abuse10.4HFE, TF
30autosomal recessive disease10.4HFE, CP
31malaria10.3CP, MIF
32cerebritis10.3
33glomerulonephritis10.3
34hemoglobinopathy10.3HFE, EPO, TF
35anemia, hypochromic microcytic10.2SLC11A2, CP, TF
36pulmonary function10.2
37secondary hyperparathyroidism of renal origin10.2EPO, CALCA
38factor v leiden thrombophilia10.2CP, EPO, HFE
39acute respiratory distress syndrome10.2TF, MIF
40myelodysplastic syndrome10.2TF, EPO, HFE
41galactosemia10.2TF, CP
42nutritional deficiency disease10.2FTL, FTH1
43vitamin b12 deficiency10.2FTL, FTH1
44exanthem10.2FTL, FTH1
45movement disease10.2CP, FTL
46secondary pulmonary hemosiderosis10.2
47pulmonary tuberculosis10.2CAT, CP
48mucoepidermoid carcinoma10.2CALCA, KRT7
49uremia10.2EPO, TF
50congenital heart disease10.2HFE, EPO, CP

Graphical network of the top 20 diseases related to Hemosiderosis:



Diseases related to hemosiderosis

Symptoms for Hemosiderosis

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Drugs & Therapeutics for Hemosiderosis

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Drug clinical trials:

Search ClinicalTrials for Hemosiderosis

Search NIH Clinical Center for Hemosiderosis

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Hemosiderosis

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Anatomical Context for Hemosiderosis

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MalaCards organs/tissues related to Hemosiderosis:

31
Liver, Lung, Heart, Kidney, Spleen, Bone marrow, Bone, Pancreas, Testes, Lymph node, Brain, Skin, Placenta, Endothelial, Neutrophil

Animal Models for Hemosiderosis or affiliated genes

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MGI Mouse Phenotypes related to Hemosiderosis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.8CP, EPO, FTH1, HFE, SLC11A2
2MP:00053878.3SLC11A2, HFE, MIF, FTH1, CP, IGHE
3MP:00053977.7TF, IGHE, CP, EPO, FTH1, MIF
4MP:00107687.5TF, EPO, FTH1, CAT, CALCA, HFE
5MP:00053847.4CP, EPO, FTH1, MIF, CAT, HFE
6MP:00053766.7SLC11A2, TF, IGHE, CP, EPO, FTH1

Publications for Hemosiderosis

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Articles related to Hemosiderosis:

(show top 50)    (show all 462)
idTitleAuthorsYear
1
A case report of hemosiderosis-induced ventricular pacing exit block. (23907043)
2013
2
Melioidosis and idiopathic pulmonary hemosiderosis: a cast-iron case. (25473541)
2013
3
Child with idiopathic pulmonary hemosiderosis: a case report from Pakistan with multiple ethical and moral issues. (21968218)
2012
4
Idiopathic pulmonary hemosiderosis: alveoli are an answer to anemia. (21206122)
2011
5
Idiopathic pulmonary hemosiderosis in a 9-year-old girl. (20156739)
2009
6
Sequential antiviral and iron chelation treatment in a teenage boy with congenital anemia, chronic hepatitis C, and secondary hemosiderosis. (19274798)
2009
7
A pilot MRI study of organ specific hemosiderosis and functional correlation in Chinese patients with myelodysplasia and aplastic anemia with raised ferritin levels. (18484675)
2008
8
Longitudinal analysis of hearing loss in a case of hemosiderosis of the central nervous system. (14501449)
2003
9
Idiopathic pulmonary hemosiderosis in a child: report of one case. (11355061)
2001
10
Antioxidant therapy of cobalt and vitamin E in hemosiderosis. (9708577)
1998
11
Pulmonary hemosiderosis and immune complex glomerulonephritis. (7634551)
1995
12
Decrease in serum ferritin level in a patient with HCV hepatitis and liver hemosiderosis by interferon-alpha. (7769377)
1994
13
Superficial hemosiderosis of the central nervous system. A case report. (7992663)
1994
14
Renal hemosiderosis due to thalassemia: a light and electron microscopy study with electron probe X-ray microanalysis. (8316965)
1993
15
Diagnosis of pulmonary hemosiderosis by MR imaging. (2783811)
1989
16
Hemosiderosis and hemochromatosis in renal transplant recipients. Clinical and pathological features, diagnostic correlations, predisposing factors, and treatment. (3909817)
1985
17
Complete break in the wall of the capillary in idiopathic pulmonary hemosiderosis. (6464214)
1984
18
Increased IgD milk antibody responses in a patient with Down's syndrome, pulmonary hemosiderosis and cor pulmonale. (6226218)
1983
19
Hemosiderosis in a dialysis patient: treatment with hemofiltration and deferoxamine chelation therapy. (7087549)
1982
20
Experimental hemosiderosis: relationship between skin pigmentation and hemosiderin. (6155014)
1980
21
Nuclear scan of pulmonary hemorrhage in idiopathic pulmonary hemosiderosis. (103389)
1979
22
Iron metabolism and chelation therapy in hemosiderosis. (400529)
1978
23
Idiopathic pulmonary hemosiderosis. (642604)
1978
24
Localized hemosiderosis as a sequela of acne. (152613)
1978
25
Hemosiderosis secondary to chronic parenteral iron therapy in maintenance hemodialysis patients. (740092)
1978
26
Asymptomatic IgA nephropathy associated with pulmonary hemosiderosis. (350044)
1978
27
Renal amyloidosis with nephrotic syndrome in a child suspected of having idiopathic pulmonary hemosiderosis. (617983)
1977
28
Hyperreactivity to cow milk in young children with pulmonary hemosiderosis and cor pulmonale secondary to nasopharyngeal obstruction. (1173819)
1975
29
Idiopathic pulmonary hemosiderosis with manifestations of multiple connective tissue and immune disorders. Treatment with cyclophosphamide. (4544643)
1974
30
Effects of cyclic starvation-feeding and of splenectomy on the development of hemosiderosis in rat livers. (4814898)
1974
31
Letter: Idiopathic pulmonary hemosiderosis. (4414263)
1974
32
Complete left bundle branch block in idiopathic pulmonary hemosiderosis. (4421798)
1974
33
Idiopathic pulmonary hemosiderosis. Case report with pulmonary function tests and cardiac catheterization data. (4641225)
1972
34
Megaloblastic anemia associated with parenchymal hemosiderosis. (5231720)
1967
35
Renal hemosiderosis in patients with prosthetic aortic valves. (5904416)
1966
36
Idiopathic pulmonary hemosiderosis: case report of adult with long survival. (5833288)
1965
37
IDIOPATHIC PULMONARY HEMOSIDEROSIS ASSOCIATED WITH RENAL CHANGES AND ABNORMAL SERUM PROTEINS: REPORT OF A CASE. (14333658)
1965
38
IDIOPATHIC PULMONARY HEMOSIDEROSIS. (14215918)
1964
39
NODULAR ASPIRATIONAL PULMONARY HEMOSIDEROSIS. (14217076)
1964
40
Idiopathic pulmonary hemosiderosis in adults. Report of case and review of literature. (13939601)
1963
41
Pulmonary hemosiderosis and glomerulonephritis. (14496477)
1962
42
Pulmonary hemosiderosis with glomerulonephritis. A report of two cases. (13760442)
1961
43
Idiopathic pulmonary hemosiderosis. (13787318)
1960
44
Renal hemosiderosis in the hemolytic anemias: diagnosis by means of needle biopsy. (14415802)
1960
45
The nature of storage iron in idiopathic hemochromatosis and in hemosiderosis. Electron optical, chemical, and serologic studies on isolated hemosiderin granules. (13741389)
1960
46
Study on essential pulmonary hemosiderosis]. (13621512)
1958
47
Neuropathy, cardiopathy, hemosiderosis, and testicular atrophy in Gorilla gorilla. (13217581)
1955
48
Idiopathic pulmonary hemosiderosis. (13155826)
1954
49
Idiopathic pulmonary hemosiderosis (essential brown induration of the lungs). (14783612)
1950
50
Hemosiderosis of the lung due to mitral disease; a report of six cases simulating pneumoconiosis. (18120450)
1949

Variations for Hemosiderosis

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Expression for genes affiliated with Hemosiderosis

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Search GEO for disease gene expression data for Hemosiderosis.

Pathways for genes affiliated with Hemosiderosis

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Pathways related to Hemosiderosis according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8CP, SLC11A2
29.8EPO, SLC11A2
39.6TF, EPO, CP
49.4TF, SLC11A2, FTH1
5
Show member pathways
tetrapyrrole biosynthesis36
heme degradation36
Heme Biosynthesis36
heme biosynthesis36
heme biosynthesis from uroporphyrinogen-III I36
9.3CP, FTH1, FTL
68.9SLC11A2, FTH1, TF, FTL
7
Show member pathways
8.6FTH1, SLC11A2, TF, FTL, CP
8
Show member pathways
8.6SLC11A2, FTL, CP, TF, FTH1

Compounds for genes affiliated with Hemosiderosis

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Compounds related to Hemosiderosis according to GeneCards Suite gene sharing:

(show top 50)    (show all 95)
idCompoundScoreTop Affiliating Genes
1ferric oxide4310.1EPO, CP
2recormon4310.1EPO, TF
3ferric gluconate4310.1EPO, TF
4ferrihydrite4310.1CP, FTH1
5ferrous ammonium sulfate4310.0TF, CP, FTH1
6apotransferrin439.9TF, FTH1, CP
7iron sucrose439.9EPO, TF
8ferrozine439.8FTL, TF, CP
9nandrolone decanoate43 1210.8CALCA, EPO, TF
10dmpo-oh439.7CAT, CP
11protoporphyrin ix43 24 1211.7TF, EPO, FTL
12haem439.6HFE, SLC11A2, FTL
13dehydroascorbic acid43 1210.6TF, CP, CAT
14dtpa439.6TF, CP, CAT
15tocopherol439.6CAT, CP, TF
16iron dextran43 1210.4TF, EPO, FTL, FTH1
17glibenclamide43 28 49 5912.3MIF, CP, CALCA
18vitamin b12439.3TF, CP, EPO
19citrate439.2CP, TF, SLC11A2, CAT
20thyroxine43 2410.2TF, CP, CALCA, IGHE
21ferric ammonium citrate439.2TF, CP, FTL, CAT
22selenium43 2410.2CP, TF, CAT
23epinephrine43 24 1211.1CALCA, CP, IGHE, TF
24fe3+439.1FTH1, FTL, CP, TF, SLC11A2
25aspartate439.1IGHE, CP, EPO, TF, HFE
26mannitol43 1210.1IGHE, CP, CAT, FTH1
27folate439.0IGHE, EPO, FTL, TF, CP
28cholesterol43 28 24 1211.9HFE, FTL, CP, SLC11A2, TF
29hydrocortisone43 2 59 1211.9IGHE, EPO, MIF, CALCA, TF
30fenton438.9CP, TF, CAT, FTL, EPO
31carbohydrates438.9TF, IGHE, CP, KRT7
32methotrexate49 43 1210.8KRT7, TF, IGHE, EPO
33sialic acid438.8CP, TF, KRT7, MIF, EPO
34n acetylcysteine438.7SLC11A2, CAT, IGHE, TF
35fe2+438.7HFE, CAT, CP, TF, SLC11A2, FTH1
36copper43 249.7SLC11A2, HFE, CAT, TF, FTH1, CP
37indomethacin43 28 59 1211.7CAT, CALCA, CP, IGHE
38zinc43 249.6SLC11A2, HFE, MIF, FTH1, CP, FTL
39creatinine438.6IGHE, CALCA, EPO, CP, TF, MIF
40deferoxamine43 129.5CP, CAT, TF, FTH1, FTL, EPO
41h2o2438.5MIF, CP, FTL, FTH1, CAT
42oxygen43 249.3MIF, CAT, CP, EPO, FTL, FTH1
43vitamin a43 24 1210.3TF, CP, CAT, KRT7, IGHE
44testosterone43 59 24 1211.2EPO, CP, CALCA, KRT7, IGHE, HFE
45lactate438.0TF, MIF, CALCA, CAT, IGHE, CP
46ascorbic acid43 248.9EPO, CP, IGHE, TF, SLC11A2, HFE
47vegf437.8IGHE, CP, EPO, MIF, CALCA, TF
48estrogen437.8TF, IGHE, CP, MIF, KRT7, HFE
49lipid437.6KRT7, HFE, CAT, MIF, FTH1, FTL
50iron43 248.1CP, SLC11A2, TF, KRT7, EPO, FTL

GO Terms for genes affiliated with Hemosiderosis

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Cellular components related to Hemosiderosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1intracellular ferritin complexGO:00080439.8FTL, FTH1
2basal part of cellGO:00451789.7TF, HFE, SLC11A2
3recycling endosomeGO:00550379.6TF, HFE, SLC11A2
4early endosomeGO:00057699.2TF, HFE, SLC11A2
5cell surfaceGO:00099869.1EPO, MIF, SLC11A2, TF
6extracellular spaceGO:00056158.6CALCA, CP, MIF, TF, EPO
7extracellular vesicular exosomeGO:00700628.6MIF, FTH1, FTL, CP, TF
8extracellular regionGO:00055768.3CALCA, TF, MIF, EPO, CP, IGHE

Biological processes related to Hemosiderosis according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1multicellular organismal iron ion homeostasisGO:006058610.0HFE, SLC11A2
2negative regulation of calcium ion transport into cytosolGO:00105239.9CALCA, EPO
3copper ion transportGO:00068259.8SLC11A2, CP
4iron ion transportGO:00068269.7FTH1, FTL
5embryo implantationGO:00075669.6EPO, CALCA
6response to hyperoxiaGO:00550939.6CAT, EPO
7immune responseGO:00069559.3HFE, FTH1, IGHE
8post-Golgi vesicle-mediated transportGO:00068929.3FTH1, FTL
9transmembrane transportGO:00550858.8TF, CP, FTL, FTH1, SLC11A2
10cellular iron ion homeostasisGO:00068798.6SLC11A2, HFE, FTH1, FTL, CP, TF

Molecular functions related to Hemosiderosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1ferroxidase activityGO:00043229.9FTH1, CP
2copper ion bindingGO:00055079.8SLC11A2, CP
3ferric iron bindingGO:00081999.4FTH1, FTL, TF
4iron ion bindingGO:00055068.9SLC11A2, FTH1, FTL
5receptor bindingGO:00051028.8MIF, CAT, CALCA, HFE
6protein bindingGO:00055156.5TF, EPO, FTL, FTH1, MIF, CALCA

Products for genes affiliated with Hemosiderosis

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Sources for Hemosiderosis

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