MCID: HMS001
MIFTS: 52

Hemosiderosis malady

Summaries for Hemosiderosis

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 An iron metabolism disease that has material basis in an accumulation of hemosiderin, an iron-storage complex, resulting in iron overload.

MalaCards: Hemosiderosis, also known as haemosiderosis, is related to hemochromatosis and hepatitis. An important gene associated with Hemosiderosis is CP (ceruloplasmin (ferroxidase)), and among its related pathways are Scavenging by Class A Receptors and HIF-1-alpha transcription factor network. The drug cyclophosphamide and the compounds ferric gluconate and recormon have been mentioned in the context of this disorder. Affiliated tissues include liver, lung and heart, and related mouse phenotypes are homeostasis/metabolism and cellular.

Wikipedia:63 Hemosiderosis (AmE) or haemosiderosis (BrE) is a form of iron overload disorder resulting in the... more...

Aliases & Classifications for Hemosiderosis

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH
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Aliases & Descriptions:

hemosiderosis 8 42 10 44 60
haemosiderosis 8


External Ids:

Disease Ontology8 DOID:12119
NCIt39 C82892
SNOMED-CT56 190849009, 39011001
MeSH34 D006486

Related Diseases for Hemosiderosis

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17GeneCards, 18GeneDecks
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Diseases related to Hemosiderosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 180)
idRelated DiseaseScoreTop Affiliating Genes
1hemochromatosis30.7CP, SLC11A2, HFE, TF
2hepatitis30.7CP, HFE, CAT
3celiac disease30.5HFE
4iron deficiency anemia30.3TF, HFE, EPO, SLC11A2
5deficiency anemia30.3TF, PIGA, HFE, MIF, FTL, FTH1
6glomerulonephritis30.3CAT, MIF
7aceruloplasminemia30.2CP
8hypertension30.1CALCA
9beta thalassemia30.1HFE, TF
10hemolytic anemia30.1TF, PIGA, HFE, EPO, CP
11arthritis30.1CALCA, HFE, MIF, FTL, FTH1
12cystic fibrosis29.9CP
13sickle cell disease29.9EPO, TF
14hepatitis b29.9MIF, HFE
15microcytic anemia29.9TF, EPO, SLC11A2
16rheumatoid arthritis29.9CP, MIF, HFE
17hepatitis c29.9SLC11A2, HFE, TF
18liver cirrhosis29.9TF, HFE, SLC11A2, CP
19siderosis29.9TF, HFE, FTL, FTH1, CP
20diabetes mellitus29.9CALCA, CAT, TF, HFE, FTL, FTH1
21tuberculosis29.9MIF, SLC11A2, CP
22viral hepatitis29.7HFE
23nephrotic syndrome29.7TF
24dementia29.7CP
25adenocarcinoma29.7KRT7
26porphyria29.7TF, HFE
27meningitis29.7CAT
28acute leukemia29.7HFE, EPO
29neuropathy29.7CALCA
30pneumoconiosis29.7CP, CAT
31hypochromic microcytic anemia29.7TF, SLC11A2, CP
32thrombocytopenia29.7PIGA, HFE, EPO
33cataract29.7FTL, CAT
34leukemia29.7CAT, PIGA, HFE, EPO
35porphyria cutanea tarda29.7FTH1, FTL, HFE, TF
36vascular disease29.7FTH1, FTL, TF, CAT
37brown induration10.4
38hepatitis a10.3
39thalassemia10.3
40cerebritis10.2
41sickle cell anemia10.1
42hemoglobinuria10.1
43cerebral amyloid angiopathy10.1
44pulmonary fibrosis10.1
45gaucher's disease10.0
46systemic lupus erythematosus10.0
47hypochromic anemia10.0
48alcoholic hepatitis10.0
49hemorrhagic disease10.0
50kidney disease10.0

Graphical network of the top 20 diseases related to Hemosiderosis:



Diseases related to hemosiderosis

Clinical Features for Hemosiderosis

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Drugs & Therapeutics for Hemosiderosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Hemosiderosis

Drug clinical trials:

Search ClinicalTrials for Hemosiderosis

Search NIH Clinical Center for Hemosiderosis

Search CenterWatch for Hemosiderosis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Hemosiderosis

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Anatomical Context for Hemosiderosis

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32MalaCards
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MalaCards organs/tissues related to Hemosiderosis:

32
Liver, Lung, Heart, Kidney, Spleen, Testes, Pancreas, Bone marrow, Bone, Brain, Lymph node, Skin, Placenta, Endothelial

Animal Models for Hemosiderosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Hemosiderosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.3CALCA, TF, HFE, IGHE, EHD1, FTH1
2MP:00053847.1PIGA, EHD1, MIF, FTH1, EPO, KRT7
3MP:00053976.9CP, TF, PIGA, HFE, IGHE, EHD1
4MP:00107686.9CALCA, CAT, TF, PIGA, HFE, EHD1

Publications for Hemosiderosis

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50PubMed
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Articles related to Hemosiderosis:

(show top 50)    (show all 451)
idTitleAuthorsYear
1
A case report of hemosiderosis-induced ventricular pacing exit block. (23907043)
2013
2
Spondias pinnata stem bark extract lessens iron overloaded liver toxicity due to hemosiderosis in Swiss albino mice. (23293203)
2013
3
The importance of evaluation of Celiac disease in patients with pulmonary hemosiderosis. (23550401)
2013
4
Idiopathic pulmonary hemosiderosis: alveoli are an answer to anemia. (21206122)
2011
5
Atypical case of ocular hemosiderosis: leopard cataract. (21803538)
2011
6
Prognosis in adult patients with idiopathic pulmonary hemosiderosis. (21881278)
2011
7
Benefit of gluten-free diet in idiopathic pulmonary hemosiderosis in association with celiac disease. (20967850)
2011
8
A case of IgA nephropathy and renal hemosiderosis associated with primary hemochromatosis. (18791957)
2008
9
A few good men: a Marine with hemoptysis and diarrhea. Idiopathic pulmonary hemosiderosis and celiac sprue. (18779201)
2008
10
Silent idiopathic pulmonary hemosiderosis with iron-deficiency anemia but normal serum ferritin. (17609633)
2007
11
Auditory manifestations of superficial hemosiderosis of the central nervous system. (17252279)
2007
12
Pulmonary hemosiderosis in association with celiac disease. (17235730)
2006
13
Transfusional hemosiderosis and combined chelation therapy in sickle thalassemia. (16146544)
2005
14
Celiac disease and pulmonary hemosiderosis in a patient with chronic granulomatous disease. (15334514)
2004
15
Longitudinal analysis of hearing loss in a case of hemosiderosis of the central nervous system. (14501449)
2003
16
Perinatal lethal form of Gaucher's disease presenting with hemosiderosis. (11041442)
2000
17
Hepatic hemosiderosis in non-human primates: quantification of liver iron using different field strengths. (9094074)
1997
18
A mutation in the ceruloplasmin gene is associated with systemic hemosiderosis in humans. (7539672)
1995
19
From the Centers for Disease Control and Prevention. Acute pulmonary hemorrhage/hemosiderosis among infants--Cleveland, January 1993-November 1994. (7815646)
1995
20
Superficial hemosiderosis in a second trimester fetus: pathological and clinical manifestations. (7672787)
1995
21
Hemosiderosis and dietary iron in birds. (7996269)
1994
22
Renal hemosiderosis due to thalassemia: a light and electron microscopy study with electron probe X-ray microanalysis. (8316965)
1993
23
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 16-1993. A 13-year-old girl with gross hematuria four years after a diagnosis of idiopathic pulmonary hemosiderosis. (8455686)
1993
24
Blue nasal secretions: a presentation of Gaucher's disease and concurrent hemosiderosis. (8213785)
1993
25
Successful treatment of hemosiderosis with regular phlebotomy and recombinant human erythropoietin. Case report and ferrokinetic studies. (1805491)
1991
26
Long-term clinical follow-up of adult idiopathic pulmonary hemosiderosis and celiac disease. (2036845)
1991
27
Rheumatoid-like arthritis presenting as idiopathic pulmonary hemosiderosis: a report and review of the literature. (3820207)
1986
28
Detoxification in hemosiderosis. (3913449)
1985
29
Hemosiderosis in a dialysis patient: treatment with hemofiltration and deferoxamine chelation therapy. (7087549)
1982
30
A metabolic disorder similar to Zellweger syndrome with hepatic acatalasia and absence of peroxisomes, altered content and redox state of cytochromes, and infantile cirrhosis with hemosiderosis. (844460)
1977
31
Idiopathic pulmonary hemosiderosis: ferrokinetic remarks. (812785)
1975
32
Effects of cyclic starvation-feeding and of splenectomy on the development of hemosiderosis in rat livers. (4814898)
1974
33
Letter: Idiopathic pulmonary hemosiderosis. (4414263)
1974
34
Severe idiopathic pulmonary hemosiderosis in the absence of clinical or radiologic evidence of pulmonary disease. (5790393)
1969
35
Idiopathic pulmonary hemosiderosis. Report of three cases. (5939060)
1966
36
The iron content of jejunal mucosa obtained by Crosby's biopsy in hemochromatosis and hemosiderosis. (5944263)
1966
37
Idiopathic pulmonary hemosiderosis: an autopsy case. (5898244)
1965
38
HEMOSIDEROSIS VERSUS HEMOCHROMATOSIS: REFRACTORY ANEMIA, HEPATIC DYSFUNCTION, DIABETES AND INCREASED TISSUE IRON DEPOSITS. (14266833)
1965
39
Transfusion hemosiderosis. Report of a case treated with desferrioxamine-B. (5835475)
1965
40
IDIOPATHIC PULMONARY HEMOSIDEROSIS AND GLOMERULONEPHRITIS: REPORT OF A CASE. (14114643)
1964
41
OBSERVATIONS ON THE PULMONARY VASCULATURE IN A CASE OF CENTRILOBULAR EMPHYSEMA WITH HEMOSIDEROSIS. (14059465)
1963
42
Diet-induced hemolytic anemia in the rat. Concomitant renal hemosiderosis. (13986177)
1962
43
Radiologic sign in hemosiderosis. (13575118)
1958
44
Focal pulmonary hemosiderosis in rheumatic heart disease. (14350131)
1955
45
BAL-therapy in transfusion hemosiderosis. (13186783)
1954
46
Transfusion hemosiderosis; report of a case. (13126204)
1953
47
Transfusion hemosiderosis; report of a case treated with BAL. (13079654)
1953
48
Essential pulmonary hemosiderosis; report of a case. (13079650)
1953
49
Lung: essential pulmonary hemosiderosis. (13019164)
1952
50
Acute myelogenous leukemia. Report of a case receiving 214 blood transfusions and with the development of hemosiderosis. (14827107)
1951

Genetic Variations for Hemosiderosis

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Expression for genes affiliated with Hemosiderosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hemosiderosis

Search GEO for disease gene expression data for Hemosiderosis.

Pathways for genes affiliated with Hemosiderosis

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53Reactome, 37NCBI BioSystems Database, 29KEGG
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Compounds for genes affiliated with Hemosiderosis

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44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Hemosiderosis according to GeneCards/GeneDecks:

(show top 50)    (show all 75)
idCompoundScoreTop Affiliating Genes
1ferric gluconate4410.3EPO, TF
2recormon4410.3TF, EPO
3fenton4410.3FTL, CP
4ferric oxide4410.3EPO, CP
5ferrihydrite4410.2CP, FTH1
6deferiprone4410.2TF, EPO
7iron sucrose4410.2TF, EPO
8ferrous ammonium sulfate4410.1FTH1, TF, CP
9apotransferrin4410.1FTH1, CP, TF
10dmpo-oh4410.1CP, CAT
11ferrozine4410.0TF, FTL, CP
12nandrolone decanoate44 1111.0EPO, TF, CALCA
13protoporphyrin ix44 11 2411.9FTL, EPO, TF
14dehydroascorbic acid44 1110.9CP, CAT, TF
15dtpa449.9TF, CP, CAT
16tocopherol449.9CP, TF, CAT
17haem449.9SLC11A2, FTL, HFE
18vitamin b12449.8TF, EPO, CP
19aspartate449.7HFE, IGHE, CP
20iron dextran44 1110.7EPO, TF, FTL, FTH1
21glibenclamide44 28 49 5912.7CALCA, MIF, CP
22oxygen44 2410.7FTL, FTH1, EPO
23vitamin a44 11 2411.7CP, IGHE, CAT
24aluminium44 1110.7TF, EPO
25selenium44 2410.6CAT, TF, CP
26mannitol44 1110.6FTH1, IGHE, CAT
27ferric ammonium citrate449.6FTL, TF, CP, CAT
28citrate449.6TF, CP, CAT, SLC11A2
29malondialdehyde449.5EPO, CP, CAT
30betacarotene449.4CAT, CP, TF
31thyroxine44 2410.4CALCA, TF, CP, IGHE
32fe3+449.4FTL, CP, SLC11A2, FTH1, TF
33cyclophosphamide44 49 1111.4MIF, IGHE, PIGA, TF
34folate449.2CP, FTL, TF, IGHE, EPO
35carbohydrates449.2KRT7, IGHE, TF, CP
36sialic acid449.2KRT7, TF, MIF, EPO, CP
37hydrocortisone44 2 59 1112.1EPO, CALCA, IGHE, TF, MIF
38fe2+449.1SLC11A2, HFE, CP, FTH1, CAT, TF
39copper44 2410.1FTH1, CAT, SLC11A2, CP, TF, HFE
40epinephrine44 11 2411.1CALCA, TF, IGHE, CP
41methotrexate44 49 1111.0KRT7, TF, EPO, IGHE
42deferoxamine44 1110.0FTL, CAT, FTH1, TF, CP, EPO
43zinc44 249.9CP, SLC11A2, HFE, FTH1, FTL, MIF
44creatinine448.9TF, CALCA, IGHE, MIF, EPO, CP
45testosterone44 59 11 2411.6KRT7, CALCA, EPO, IGHE, CP, HFE
46lactate448.4CAT, CP, EPO, MIF, TF, IGHE
47ascorbic acid44 249.3CP, SLC11A2, IGHE, HFE, TF, CAT
48vegf448.3CP, CALCA, IGHE, MIF, EPO, KRT7
49lipid448.2FTH1, MIF, HFE, FTL, CAT, KRT7
50iron44 248.8TF, KRT7, SLC11A2, EPO, FTH1, FTL

GO Terms for genes affiliated with Hemosiderosis

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16Gene Ontology
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Cellular components related to Hemosiderosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intracellular ferritin complexGO:0080439.8FTH1, FTL
2basal part of cellGO:0451789.7SLC11A2, HFE, TF
3recycling endosomeGO:0550379.6SLC11A2, HFE, TF
4early endosomeGO:0057699.4TF, HFE, SLC11A2
5extracellular regionGO:0055768.5CP, EPO, MIF, IGHE, TF, CALCA

Biological processes related to Hemosiderosis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of calcium ion transport into cytosolGO:0105239.9EPO, CALCA
2multicellular organismal iron ion homeostasisGO:0605869.9SLC11A2, HFE
3iron ion transportGO:0068269.8FTH1, FTL
4response to hyperoxiaGO:0550939.7CAT, EPO
5copper ion transportGO:0068259.6CP, SLC11A2
6transmembrane transportGO:0550859.0TF, FTL, FTH1, SLC11A2, CP
7cellular iron ion homeostasisGO:0068798.9CP, TF, HFE, FTL, FTH1, SLC11A2

Molecular functions related to Hemosiderosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ferroxidase activityGO:0043229.6FTH1, CP
2ferric iron bindingGO:0081999.5FTH1, FTL, TF
3receptor bindingGO:0051029.1MIF, HFE, CAT, CALCA
4protein bindingGO:0055155.6CALCA, TF, PIGA, HFE, ANKHD1, EHD1

Products for genes affiliated with Hemosiderosis

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Sources for Hemosiderosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet