Aliases & Classifications for Hemosiderosis

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Aliases & Descriptions for Hemosiderosis:

Name: Hemosiderosis 8 42 10 44 61
 
Haemosiderosis 8


Classifications:



External Ids:

Disease Ontology8 DOID:12119
NCIt39 C82892
SNOMED-CT56 39011001, 190849009
MeSH33 D006486

Summaries for Hemosiderosis

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Disease Ontology:8 An iron metabolism disease that has material basis in an accumulation of hemosiderin, an iron-storage complex, resulting in iron overload.

MalaCards based summary: Hemosiderosis, also known as haemosiderosis, is related to hemochromatosis and hepatitis. An important gene associated with Hemosiderosis is CP (ceruloplasmin (ferroxidase)), and among its related pathways are Metal ion SLC transporters and HIF-2-alpha transcription factor network. The drug cyclophosphamide and the compounds ferric oxide and recormon have been mentioned in the context of this disorder. Affiliated tissues include liver, lung and heart, and related mouse phenotypes are liver/biliary system and immune system.

Wikipedia:64 Hemosiderosis (AmE) or haemosiderosis (BrE) is a form of iron overload disorder resulting in the... more...

Related Diseases for Hemosiderosis

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Diseases related to Hemosiderosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 157)
idRelated DiseaseScoreTop Affiliating Genes
1hemochromatosis31.1SLC11A2, HFE, CP, TF
2hepatitis31.1CP, CAT, HFE
3aceruloplasminemia30.8CP
4iron deficiency anemia30.6TF, EPO, HFE, SLC11A2
5hemolytic anemia30.4HFE, EPO, CP, TF
6porphyria30.4TF, HFE
7pneumoconiosis30.3CP, CAT
8sickle cell disease30.3EPO, TF
9tuberculosis30.3CP, MIF, SLC11A2
10liver cirrhosis30.2TF, CP, HFE
11microcytic anemia30.2TF, EPO, SLC11A2
12hepatitis c30.2SLC11A2, HFE, TF
13thalassemia30.1SLC11A2, HFE, FTH1, FTL, EPO, TF
14rheumatoid arthritis30.1HFE, MIF, CP
15siderosis29.9TF, CP, FTL, FTH1, HFE
16porphyria cutanea tarda29.8TF, FTL, FTH1, HFE
17arthritis29.7FTL, FTH1, MIF, CALCA, HFE
18vascular disease29.6TF, FTL, FTH1, CAT
19deficiency anemia29.5TF, CP, SLC11A2, HFE, MIF, FTH1
20hfe-associated hereditary hemochromatosis10.5HFE
21metanephric adenoma10.5KRT7
22brown induration10.5
23celiac disease10.4
24pityriasis versicolor10.4CAT
25bantu siderosis10.4HFE, TF
26iron metabolism disease10.4HFE, TF
27thalassemia, hispanic gamma-delta-beta10.4TF, HFE
28pancytopenia10.4EPO, CP
29alcohol abuse10.4HFE, TF
30autosomal recessive disease10.4HFE, CP
31malaria10.3CP, MIF
32cerebritis10.3
33glomerulonephritis10.3
34hemoglobinopathy10.3HFE, EPO, TF
35anemia, hypochromic microcytic10.2SLC11A2, CP, TF
36pulmonary function10.2
37secondary hyperparathyroidism of renal origin10.2EPO, CALCA
38factor v leiden thrombophilia10.2CP, EPO, HFE
39acute respiratory distress syndrome10.2TF, MIF
40myelodysplastic syndrome10.2TF, EPO, HFE
41galactosemia10.2TF, CP
42nutritional deficiency disease10.2FTL, FTH1
43vitamin b12 deficiency10.2FTL, FTH1
44exanthem10.2FTL, FTH1
45movement disease10.2CP, FTL
46secondary pulmonary hemosiderosis10.2
47pulmonary tuberculosis10.2CAT, CP
48mucoepidermoid carcinoma10.2CALCA, KRT7
49uremia10.2EPO, TF
50congenital heart disease10.2HFE, EPO, CP

Graphical network of the top 20 diseases related to Hemosiderosis:



Diseases related to hemosiderosis

Symptoms for Hemosiderosis

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Drugs & Therapeutics for Hemosiderosis

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Drug clinical trials:

Search ClinicalTrials for Hemosiderosis

Search NIH Clinical Center for Hemosiderosis

Inferred drug relations via UMLS61/NDF-RT40:

Genetic Tests for Hemosiderosis

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Anatomical Context for Hemosiderosis

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MalaCards organs/tissues related to Hemosiderosis:

31
Liver, Lung, Heart, Kidney, Spleen, Bone marrow, Bone, Pancreas, Testes, Lymph node, Brain, Skin, Placenta, Endothelial, Neutrophil

Animal Models for Hemosiderosis or affiliated genes

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MGI Mouse Phenotypes related to Hemosiderosis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.8CP, EPO, FTH1, HFE, SLC11A2
2MP:00053878.3SLC11A2, HFE, MIF, FTH1, CP, IGHE
3MP:00053977.7TF, IGHE, CP, EPO, FTH1, MIF
4MP:00107687.5TF, EPO, FTH1, CAT, CALCA, HFE
5MP:00053847.4CP, EPO, FTH1, MIF, CAT, HFE
6MP:00053766.7SLC11A2, TF, IGHE, CP, EPO, FTH1

Publications for Hemosiderosis

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Articles related to Hemosiderosis:

(show top 50)    (show all 462)
idTitleAuthorsYear
1
A case report of hemosiderosis-induced ventricular pacing exit block. (23907043)
2013
2
Melioidosis and idiopathic pulmonary hemosiderosis: a cast-iron case. (25473541)
2013
3
Child with idiopathic pulmonary hemosiderosis: a case report from Pakistan with multiple ethical and moral issues. (21968218)
2012
4
Idiopathic pulmonary hemosiderosis: alveoli are an answer to anemia. (21206122)
2011
5
Idiopathic pulmonary hemosiderosis in a 9-year-old girl. (20156739)
2009
6
Sequential antiviral and iron chelation treatment in a teenage boy with congenital anemia, chronic hepatitis C, and secondary hemosiderosis. (19274798)
2009
7
A pilot MRI study of organ specific hemosiderosis and functional correlation in Chinese patients with myelodysplasia and aplastic anemia with raised ferritin levels. (18484675)
2008
8
Longitudinal analysis of hearing loss in a case of hemosiderosis of the central nervous system. (14501449)
2003
9
Idiopathic pulmonary hemosiderosis in a child: report of one case. (11355061)
2001
10
Antioxidant therapy of cobalt and vitamin E in hemosiderosis. (9708577)
1998
11
Pulmonary hemosiderosis and immune complex glomerulonephritis. (7634551)
1995
12
Decrease in serum ferritin level in a patient with HCV hepatitis and liver hemosiderosis by interferon-alpha. (7769377)
1994
13
Superficial hemosiderosis of the central nervous system. A case report. (7992663)
1994
14
Renal hemosiderosis due to thalassemia: a light and electron microscopy study with electron probe X-ray microanalysis. (8316965)
1993
15
Diagnosis of pulmonary hemosiderosis by MR imaging. (2783811)
1989
16
Hemosiderosis and hemochromatosis in renal transplant recipients. Clinical and pathological features, diagnostic correlations, predisposing factors, and treatment. (3909817)
1985
17
Complete break in the wall of the capillary in idiopathic pulmonary hemosiderosis. (6464214)
1984
18
Increased IgD milk antibody responses in a patient with Down's syndrome, pulmonary hemosiderosis and cor pulmonale. (6226218)
1983
19
Hemosiderosis in a dialysis patient: treatment with hemofiltration and deferoxamine chelation therapy. (7087549)
1982
20
Experimental hemosiderosis: relationship between skin pigmentation and hemosiderin. (6155014)
1980
21
Nuclear scan of pulmonary hemorrhage in idiopathic pulmonary hemosiderosis. (103389)
1979
22
Iron metabolism and chelation therapy in hemosiderosis. (400529)
1978
23
Idiopathic pulmonary hemosiderosis. (642604)
1978
24
Localized hemosiderosis as a sequela of acne. (152613)
1978
25
Hemosiderosis secondary to chronic parenteral iron therapy in maintenance hemodialysis patients. (740092)
1978
26
Asymptomatic IgA nephropathy associated with pulmonary hemosiderosis. (350044)
1978
27
Renal amyloidosis with nephrotic syndrome in a child suspected of having idiopathic pulmonary hemosiderosis. (617983)
1977
28
Hyperreactivity to cow milk in young children with pulmonary hemosiderosis and cor pulmonale secondary to nasopharyngeal obstruction. (1173819)
1975
29
Idiopathic pulmonary hemosiderosis with manifestations of multiple connective tissue and immune disorders. Treatment with cyclophosphamide. (4544643)
1974
30
Effects of cyclic starvation-feeding and of splenectomy on the development of hemosiderosis in rat livers. (4814898)
1974
31
Letter: Idiopathic pulmonary hemosiderosis. (4414263)
1974
32
Complete left bundle branch block in idiopathic pulmonary hemosiderosis. (4421798)
1974
33
Idiopathic pulmonary hemosiderosis. Case report with pulmonary function tests and cardiac catheterization data. (4641225)
1972
34
Megaloblastic anemia associated with parenchymal hemosiderosis. (5231720)
1967
35
Renal hemosiderosis in patients with prosthetic aortic valves. (5904416)
1966
36
Idiopathic pulmonary hemosiderosis: case report of adult with long survival. (5833288)
1965
37
IDIOPATHIC PULMONARY HEMOSIDEROSIS ASSOCIATED WITH RENAL CHANGES AND ABNORMAL SERUM PROTEINS: REPORT OF A CASE. (14333658)
1965
38
IDIOPATHIC PULMONARY HEMOSIDEROSIS. (14215918)
1964
39
NODULAR ASPIRATIONAL PULMONARY HEMOSIDEROSIS. (14217076)
1964
40
Idiopathic pulmonary hemosiderosis in adults. Report of case and review of literature. (13939601)
1963
41
Pulmonary hemosiderosis and glomerulonephritis. (14496477)
1962
42
Pulmonary hemosiderosis with glomerulonephritis. A report of two cases. (13760442)
1961
43
Idiopathic pulmonary hemosiderosis. (13787318)
1960
44
Renal hemosiderosis in the hemolytic anemias: diagnosis by means of needle biopsy. (14415802)
1960
45
The nature of storage iron in idiopathic hemochromatosis and in hemosiderosis. Electron optical, chemical, and serologic studies on isolated hemosiderin granules. (13741389)
1960
46
Study on essential pulmonary hemosiderosis]. (13621512)
1958
47
Neuropathy, cardiopathy, hemosiderosis, and testicular atrophy in Gorilla gorilla. (13217581)
1955
48
Idiopathic pulmonary hemosiderosis. (13155826)
1954
49
Idiopathic pulmonary hemosiderosis (essential brown induration of the lungs). (14783612)
1950
50
Hemosiderosis of the lung due to mitral disease; a report of six cases simulating pneumoconiosis. (18120450)
1949

Variations for Hemosiderosis

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Expression for genes affiliated with Hemosiderosis

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Search GEO for disease gene expression data for Hemosiderosis.

Pathways for genes affiliated with Hemosiderosis

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Pathways related to Hemosiderosis according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8SLC11A2, CP
29.8SLC11A2, EPO
39.6TF, CP, EPO
49.4SLC11A2, FTH1, TF
5
Show member pathways
tetrapyrrole biosynthesis36
heme degradation36
Heme Biosynthesis36
heme biosynthesis36
heme biosynthesis from uroporphyrinogen-III I36
9.3CP, FTL, FTH1
68.9TF, FTL, FTH1, SLC11A2
7
Show member pathways
8.6TF, CP, FTL, FTH1, SLC11A2
8
Show member pathways
8.6SLC11A2, FTH1, FTL, CP, TF

Compounds for genes affiliated with Hemosiderosis

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Compounds related to Hemosiderosis according to GeneCards Suite gene sharing:

(show top 50)    (show all 95)
idCompoundScoreTop Affiliating Genes
1ferric oxide4410.1EPO, CP
2recormon4410.1EPO, TF
3ferric gluconate4410.1EPO, TF
4ferrihydrite4410.1CP, FTH1
5ferrous ammonium sulfate4410.0TF, CP, FTH1
6apotransferrin449.9TF, FTH1, CP
7iron sucrose449.9EPO, TF
8ferrozine449.8FTL, TF, CP
9nandrolone decanoate44 1110.8CALCA, EPO, TF
10dmpo-oh449.7CAT, CP
11protoporphyrin ix44 24 1111.7TF, EPO, FTL
12haem449.6HFE, SLC11A2, FTL
13dehydroascorbic acid44 1110.6TF, CP, CAT
14dtpa449.6TF, CP, CAT
15tocopherol449.6CAT, CP, TF
16iron dextran44 1110.4TF, EPO, FTL, FTH1
17glibenclamide44 28 50 6012.3MIF, CP, CALCA
18vitamin b12449.3TF, CP, EPO
19citrate449.2CP, TF, SLC11A2, CAT
20thyroxine44 2410.2TF, CP, CALCA, IGHE
21ferric ammonium citrate449.2TF, CP, FTL, CAT
22selenium44 2410.2CP, TF, CAT
23epinephrine44 24 1111.1CALCA, CP, IGHE, TF
24fe3+449.1FTH1, FTL, CP, TF, SLC11A2
25aspartate449.1IGHE, CP, EPO, TF, HFE
26mannitol44 1110.1IGHE, CP, CAT, FTH1
27folate449.0IGHE, EPO, FTL, TF, CP
28cholesterol44 28 24 1111.9HFE, FTL, CP, SLC11A2, TF
29hydrocortisone44 1 60 1111.9IGHE, EPO, MIF, CALCA, TF
30fenton448.9CP, TF, CAT, FTL, EPO
31carbohydrates448.9TF, IGHE, CP, KRT7
32methotrexate50 44 1110.8KRT7, TF, IGHE, EPO
33sialic acid448.8CP, TF, KRT7, MIF, EPO
34n acetylcysteine448.7SLC11A2, CAT, IGHE, TF
35fe2+448.7HFE, CAT, CP, TF, SLC11A2, FTH1
36copper44 249.7SLC11A2, HFE, CAT, TF, FTH1, CP
37indomethacin44 28 60 1111.7CAT, CALCA, CP, IGHE
38zinc44 249.6SLC11A2, HFE, MIF, FTH1, CP, FTL
39creatinine448.6IGHE, CALCA, EPO, CP, TF, MIF
40deferoxamine44 119.5CP, CAT, TF, FTH1, FTL, EPO
41h2o2448.5MIF, CP, FTL, FTH1, CAT
42oxygen44 249.3MIF, CAT, CP, EPO, FTL, FTH1
43vitamin a44 24 1110.3TF, CP, CAT, KRT7, IGHE
44testosterone44 60 24 1111.2EPO, CP, CALCA, KRT7, IGHE, HFE
45lactate448.0TF, MIF, CALCA, CAT, IGHE, CP
46ascorbic acid44 248.9EPO, CP, IGHE, TF, SLC11A2, HFE
47vegf447.8IGHE, CP, EPO, MIF, CALCA, TF
48estrogen447.8TF, IGHE, CP, MIF, KRT7, HFE
49lipid447.6KRT7, HFE, CAT, MIF, FTH1, FTL
50iron44 248.1CP, SLC11A2, TF, KRT7, EPO, FTL

GO Terms for genes affiliated with Hemosiderosis

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Cellular components related to Hemosiderosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1intracellular ferritin complexGO:00080439.8FTH1, FTL
2basal part of cellGO:00451789.7SLC11A2, HFE, TF
3recycling endosomeGO:00550379.6TF, HFE, SLC11A2
4early endosomeGO:00057699.2TF, HFE, SLC11A2
5cell surfaceGO:00099869.1TF, EPO, MIF, SLC11A2
6extracellular spaceGO:00056158.6CALCA, MIF, EPO, CP, TF
7extracellular vesicular exosomeGO:00700628.6MIF, FTH1, FTL, CP, TF
8extracellular regionGO:00055768.3TF, IGHE, CP, EPO, MIF, CALCA

Biological processes related to Hemosiderosis according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1multicellular organismal iron ion homeostasisGO:006058610.0HFE, SLC11A2
2negative regulation of calcium ion transport into cytosolGO:00105239.9CALCA, EPO
3copper ion transportGO:00068259.8SLC11A2, CP
4iron ion transportGO:00068269.7FTH1, FTL
5embryo implantationGO:00075669.6EPO, CALCA
6response to hyperoxiaGO:00550939.6CAT, EPO
7immune responseGO:00069559.3HFE, FTH1, IGHE
8post-Golgi vesicle-mediated transportGO:00068929.3FTH1, FTL
9transmembrane transportGO:00550858.8TF, CP, FTL, FTH1, SLC11A2
10cellular iron ion homeostasisGO:00068798.6SLC11A2, HFE, FTH1, FTL, CP, TF

Molecular functions related to Hemosiderosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1ferroxidase activityGO:00043229.9FTH1, CP
2copper ion bindingGO:00055079.8SLC11A2, CP
3ferric iron bindingGO:00081999.4FTH1, FTL, TF
4iron ion bindingGO:00055068.9SLC11A2, FTH1, FTL
5receptor bindingGO:00051028.8MIF, CAT, CALCA, HFE
6protein bindingGO:00055156.5TF, EPO, FTL, FTH1, MIF, CALCA

Sources for Hemosiderosis

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
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44Novoseek
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47OMIM via Orphanet
51PubMed
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57SNOMED-CT via Orphanet
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62UMLS via Orphanet