MCID: HMS001
MIFTS: 57

Hemosiderosis malady

Rare diseases, Metabolic diseases categories
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Summaries for Hemosiderosis

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Disease Ontology:8 An iron metabolism disease that has material basis in an accumulation of hemosiderin, an iron-storage complex, resulting in iron overload.

MalaCards based summary: Hemosiderosis, also known as haemosiderosis, is related to hemochromatosis and hepatitis. An important gene associated with Hemosiderosis is CP (ceruloplasmin (ferroxidase)), and among its related pathways are Metal ion SLC transporters and HIF-2-alpha transcription factor network. The drug cyclophosphamide and the compounds ferric oxide and recormon have been mentioned in the context of this disorder. Affiliated tissues include liver, lung and heart, and related mouse phenotypes are liver/biliary system and immune system.

Wikipedia:65 Hemosiderosis (AmE) or haemosiderosis (BrE) is a form of iron overload disorder resulting in the... more...

Aliases & Classifications for Hemosiderosis

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Hemosiderosis, Aliases & Descriptions:

Name: Hemosiderosis 8 42 10 44 62
 
Haemosiderosis 8 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Metabolic diseases


External Ids:

Disease Ontology8 DOID:12119
NCIt39 C82892
SNOMED-CT57 39011001, 190849009
MeSH34 D006486

Related Diseases for Hemosiderosis

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Diseases related to Hemosiderosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 158)
idRelated DiseaseScoreTop Affiliating Genes
1hemochromatosis31.1SLC11A2, HFE, CP, TF
2hepatitis31.1CP, CAT, HFE
3aceruloplasminemia31.1CP
4beta thalassemia30.8TF, HFE
5iron deficiency anemia30.7TF, EPO, HFE, SLC11A2
6hemolytic anemia30.4HFE, EPO, CP, TF
7porphyria30.4TF, HFE
8pneumoconiosis30.3CP, CAT
9sickle cell disease30.3EPO, TF
10tuberculosis30.3CP, MIF, SLC11A2
11liver cirrhosis30.2TF, CP, HFE
12microcytic anemia30.2TF, EPO, SLC11A2
13hepatitis c30.2SLC11A2, HFE, TF
14rheumatoid arthritis30.1HFE, MIF, CP
15siderosis29.9TF, CP, FTL, FTH1, HFE
16porphyria cutanea tarda29.8TF, FTL, FTH1, HFE
17arthritis29.7FTL, FTH1, MIF, CALCA, HFE
18vascular disease29.7TF, FTL, FTH1, CAT
19deficiency anemia29.6TF, CP, SLC11A2, HFE, MIF, FTH1
20diabetes mellitus29.2TF, CP, FTL, FTH1, CAT, CALCA
21hfe-associated hereditary hemochromatosis10.5HFE
22brown induration10.5
23metanephric adenoma10.5KRT7
24pityriasis versicolor10.4CAT
25celiac disease10.4
26bantu siderosis10.4HFE, TF
27iron metabolism disease10.4HFE, TF
28thalassemia10.4
29pancytopenia10.4EPO, CP
30alcohol abuse10.4HFE, TF
31schimke immunoosseous dysplasia10.4HFE, CP
32malaria10.3CP, MIF
33glomerulonephritis10.3
34cerebritis10.3
35hemoglobinopathy10.3HFE, EPO, TF
36hypochromic microcytic anemia10.3SLC11A2, CP, TF
37secondary hyperparathyroidism of renal origin10.3EPO, CALCA
38factor v leiden thrombophilia10.2CP, EPO, HFE
39adult respiratory distress syndrome10.2TF, MIF
40myelodysplastic syndromes10.2TF, EPO, HFE
41pulmonary function10.2
42galactosemia10.2TF, CP
43nutritional deficiency disease10.2FTL, FTH1
44vitamin b12 deficiency10.2FTL, FTH1
45exanthem10.2FTL, FTH1
46movement disease10.2CP, FTL
47pulmonary tuberculosis10.2CAT, CP
48mucoepidermoid carcinoma10.2CALCA, KRT7
49uremia10.2EPO, TF
50congenital heart disease10.2HFE, EPO, CP

Graphical network of the top 20 diseases related to Hemosiderosis:



Diseases related to hemosiderosis

Symptoms for Hemosiderosis

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Drugs & Therapeutics for Hemosiderosis

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Drug clinical trials:

Search ClinicalTrials for Hemosiderosis

Search NIH Clinical Center for Hemosiderosis

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Hemosiderosis

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Anatomical Context for Hemosiderosis

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MalaCards organs/tissues related to Hemosiderosis:

32
Liver, Lung, Heart, Kidney, Spleen, Bone marrow, Bone, Pancreas, Testes, Lymph node, Brain, Skin, Placenta, Endothelial, Neutrophil

Animal Models for Hemosiderosis or affiliated genes

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MGI Mouse Phenotypes related to Hemosiderosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.8CP, EPO, FTH1, HFE, SLC11A2
2MP:00053878.3SLC11A2, HFE, MIF, FTH1, CP, IGHE
3MP:00053977.7TF, IGHE, CP, EPO, FTH1, MIF
4MP:00107687.5TF, EPO, FTH1, CAT, CALCA, HFE
5MP:00053847.4CP, EPO, FTH1, MIF, CAT, HFE
6MP:00053766.7SLC11A2, TF, IGHE, CP, EPO, FTH1

Publications for Hemosiderosis

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Articles related to Hemosiderosis:

(show top 50)    (show all 457)
idTitleAuthorsYear
1
A case report of hemosiderosis-induced ventricular pacing exit block. (23907043)
2013
2
Child with idiopathic pulmonary hemosiderosis: a case report from Pakistan with multiple ethical and moral issues. (21968218)
2012
3
Idiopathic pulmonary hemosiderosis: alveoli are an answer to anemia. (21206122)
2011
4
Idiopathic pulmonary hemosiderosis in a 9-year-old girl. (20156739)
2009
5
Sequential antiviral and iron chelation treatment in a teenage boy with congenital anemia, chronic hepatitis C, and secondary hemosiderosis. (19274798)
2009
6
A pilot MRI study of organ specific hemosiderosis and functional correlation in Chinese patients with myelodysplasia and aplastic anemia with raised ferritin levels. (18484675)
2008
7
Longitudinal analysis of hearing loss in a case of hemosiderosis of the central nervous system. (14501449)
2003
8
Idiopathic pulmonary hemosiderosis in a child: report of one case. (11355061)
2001
9
Antioxidant therapy of cobalt and vitamin E in hemosiderosis. (9708577)
1998
10
Pulmonary hemosiderosis and immune complex glomerulonephritis. (7634551)
1995
11
Decrease in serum ferritin level in a patient with HCV hepatitis and liver hemosiderosis by interferon-alpha. (7769377)
1994
12
Superficial hemosiderosis of the central nervous system. A case report. (7992663)
1994
13
Renal hemosiderosis due to thalassemia: a light and electron microscopy study with electron probe X-ray microanalysis. (8316965)
1993
14
Long-term prednisolone therapy in children with idiopathic pulmonary hemosiderosis. (8443057)
1993
15
Diagnosis of pulmonary hemosiderosis by MR imaging. (2783811)
1989
16
Hemosiderosis and hemochromatosis in renal transplant recipients. Clinical and pathological features, diagnostic correlations, predisposing factors, and treatment. (3909817)
1985
17
Complete break in the wall of the capillary in idiopathic pulmonary hemosiderosis. (6464214)
1984
18
Increased IgD milk antibody responses in a patient with Down's syndrome, pulmonary hemosiderosis and cor pulmonale. (6226218)
1983
19
Hemosiderosis in a dialysis patient: treatment with hemofiltration and deferoxamine chelation therapy. (7087549)
1982
20
Experimental hemosiderosis: relationship between skin pigmentation and hemosiderin. (6155014)
1980
21
Nuclear scan of pulmonary hemorrhage in idiopathic pulmonary hemosiderosis. (103389)
1979
22
Iron metabolism and chelation therapy in hemosiderosis. (400529)
1978
23
Idiopathic pulmonary hemosiderosis. (642604)
1978
24
Localized hemosiderosis as a sequela of acne. (152613)
1978
25
Hemosiderosis secondary to chronic parenteral iron therapy in maintenance hemodialysis patients. (740092)
1978
26
Asymptomatic IgA nephropathy associated with pulmonary hemosiderosis. (350044)
1978
27
Renal amyloidosis with nephrotic syndrome in a child suspected of having idiopathic pulmonary hemosiderosis. (617983)
1977
28
Hyperreactivity to cow milk in young children with pulmonary hemosiderosis and cor pulmonale secondary to nasopharyngeal obstruction. (1173819)
1975
29
Idiopathic pulmonary hemosiderosis with manifestations of multiple connective tissue and immune disorders. Treatment with cyclophosphamide. (4544643)
1974
30
Effects of cyclic starvation-feeding and of splenectomy on the development of hemosiderosis in rat livers. (4814898)
1974
31
Letter: Idiopathic pulmonary hemosiderosis. (4414263)
1974
32
Complete left bundle branch block in idiopathic pulmonary hemosiderosis. (4421798)
1974
33
Idiopathic pulmonary hemosiderosis. Case report with pulmonary function tests and cardiac catheterization data. (4641225)
1972
34
Megaloblastic anemia associated with parenchymal hemosiderosis. (5231720)
1967
35
Renal hemosiderosis in patients with prosthetic aortic valves. (5904416)
1966
36
Idiopathic pulmonary hemosiderosis: case report of adult with long survival. (5833288)
1965
37
IDIOPATHIC PULMONARY HEMOSIDEROSIS ASSOCIATED WITH RENAL CHANGES AND ABNORMAL SERUM PROTEINS: REPORT OF A CASE. (14333658)
1965
38
IDIOPATHIC PULMONARY HEMOSIDEROSIS. (14215918)
1964
39
NODULAR ASPIRATIONAL PULMONARY HEMOSIDEROSIS. (14217076)
1964
40
Idiopathic pulmonary hemosiderosis in adults. Report of case and review of literature. (13939601)
1963
41
Pulmonary hemosiderosis and glomerulonephritis. (14496477)
1962
42
Pulmonary hemosiderosis with glomerulonephritis. A report of two cases. (13760442)
1961
43
Idiopathic pulmonary hemosiderosis. (13787318)
1960
44
Renal hemosiderosis in the hemolytic anemias: diagnosis by means of needle biopsy. (14415802)
1960
45
The nature of storage iron in idiopathic hemochromatosis and in hemosiderosis. Electron optical, chemical, and serologic studies on isolated hemosiderin granules. (13741389)
1960
46
Study on essential pulmonary hemosiderosis]. (13621512)
1958
47
Neuropathy, cardiopathy, hemosiderosis, and testicular atrophy in Gorilla gorilla. (13217581)
1955
48
Idiopathic pulmonary hemosiderosis. (13155826)
1954
49
Idiopathic pulmonary hemosiderosis (essential brown induration of the lungs). (14783612)
1950
50
Hemosiderosis of the lung due to mitral disease; a report of six cases simulating pneumoconiosis. (18120450)
1949

Variations for Hemosiderosis

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Expression for genes affiliated with Hemosiderosis

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Expression patterns in normal tissues for genes affiliated with Hemosiderosis

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Pathways for genes affiliated with Hemosiderosis

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Pathways related to Hemosiderosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8CP, SLC11A2
29.8EPO, SLC11A2
39.6TF, EPO, CP
49.4TF, SLC11A2, FTH1
5
Show member pathways
tetrapyrrole biosynthesis37
heme degradation37
Heme Biosynthesis37
heme biosynthesis37
heme biosynthesis from uroporphyrinogen-III I37
9.3CP, FTH1, FTL
68.9SLC11A2, FTH1, TF, FTL
7
Show member pathways
8.6FTH1, SLC11A2, TF, FTL, CP
8
Show member pathways
8.6SLC11A2, FTL, CP, TF, FTH1

Compounds for genes affiliated with Hemosiderosis

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Compounds related to Hemosiderosis according to GeneCards/GeneDecks:

(show top 50)    (show all 95)
idCompoundScoreTop Affiliating Genes
1ferric oxide4410.1EPO, CP
2recormon4410.1EPO, TF
3ferric gluconate4410.1EPO, TF
4ferrihydrite4410.1FTH1, CP
5ferrous ammonium sulfate4410.0TF, CP, FTH1
6apotransferrin449.9FTH1, CP, TF
7deferiprone449.9EPO, TF
8ferrozine449.8TF, CP, FTL
9nandrolone decanoate44 1110.8TF, EPO, CALCA
10dmpo-oh449.7CP, CAT
11protoporphyrin ix44 24 1111.7FTL, EPO, TF
12haem449.6FTL, HFE, SLC11A2
13dehydroascorbic acid44 1110.6TF, CP, CAT
14dtpa449.6CAT, CP, TF
15tocopherol449.6CAT, CP, TF
16iron dextran44 1110.4TF, EPO, FTL, FTH1
17glibenclamide44 28 50 6112.3CALCA, MIF, CP
18vitamin b12449.3EPO, CP, TF
19citrate449.2SLC11A2, CAT, CP, TF
20thyroxine44 2410.2TF, IGHE, CP, CALCA
21ferric ammonium citrate449.2TF, CP, FTL, CAT
22selenium44 2410.2TF, CP, CAT
23epinephrine44 24 1111.1TF, IGHE, CP, CALCA
24fe3+449.1SLC11A2, FTH1, FTL, CP, TF
25aspartate449.1TF, IGHE, CP, EPO, HFE
26mannitol44 1110.1IGHE, CP, FTH1, CAT
27folate449.0TF, IGHE, CP, EPO, FTL
28cholesterol44 28 24 1111.9SLC11A2, HFE, FTL, CP, TF
29hydrocortisone44 2 61 1111.9TF, IGHE, EPO, MIF, CALCA
30fenton448.9TF, CP, EPO, FTL, CAT
31carbohydrates448.9TF, IGHE, CP, KRT7
32methotrexate50 44 1110.8TF, IGHE, EPO, KRT7
33sialic acid448.8TF, CP, EPO, MIF, KRT7
34n acetylcysteine448.7SLC11A2, CAT, IGHE, TF
35fe2+448.7TF, CP, FTH1, CAT, HFE, SLC11A2
36copper44 249.7TF, CP, FTH1, CAT, HFE, SLC11A2
37indomethacin44 28 61 1111.7IGHE, CP, CAT, CALCA
38zinc44 249.6CP, FTL, FTH1, MIF, HFE, SLC11A2
39creatinine448.6TF, IGHE, CP, EPO, MIF, CALCA
40deferoxamine44 119.5CAT, FTH1, FTL, EPO, CP, TF
41h2o2448.5CP, FTL, FTH1, MIF, CAT
42oxygen44 249.3CP, EPO, FTL, FTH1, MIF, CAT
43vitamin a44 24 1110.3TF, IGHE, CP, CAT, KRT7
44testosterone44 61 24 1111.2IGHE, CP, EPO, CALCA, HFE, KRT7
45lactate448.0TF, IGHE, CP, EPO, MIF, CAT
46ascorbic acid44 248.9TF, IGHE, CP, EPO, FTH1, CAT
47vegf447.8TF, IGHE, CP, EPO, MIF, CALCA
48estrogen447.8TF, IGHE, CP, MIF, CALCA, HFE
49lipid447.6CP, FTL, FTH1, MIF, CAT, HFE
50iron44 248.1SLC11A2, TF, CP, EPO, FTL, FTH1

GO Terms for genes affiliated with Hemosiderosis

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Cellular components related to Hemosiderosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intracellular ferritin complexGO:0080439.8FTH1, FTL
2basal part of cellGO:0451789.7SLC11A2, HFE, TF
3recycling endosomeGO:0550379.6TF, HFE, SLC11A2
4early endosomeGO:0057699.2TF, HFE, SLC11A2
5cell surfaceGO:0099869.1TF, EPO, MIF, SLC11A2
6extracellular spaceGO:0056158.6CALCA, MIF, EPO, CP, TF
7extracellular vesicular exosomeGO:0700628.6MIF, FTH1, FTL, CP, TF
8extracellular regionGO:0055768.3TF, IGHE, CP, EPO, MIF, CALCA

Biological processes related to Hemosiderosis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1multicellular organismal iron ion homeostasisGO:06058610.0HFE, SLC11A2
2negative regulation of calcium ion transport into cytosolGO:0105239.9CALCA, EPO
3copper ion transportGO:0068259.8SLC11A2, CP
4iron ion transportGO:0068269.7FTH1, FTL
5embryo implantationGO:0075669.6EPO, CALCA
6response to hyperoxiaGO:0550939.6CAT, EPO
7immune responseGO:0069559.3HFE, FTH1, IGHE
8post-Golgi vesicle-mediated transportGO:0068929.3FTH1, FTL
9transmembrane transportGO:0550858.8TF, CP, FTL, FTH1, SLC11A2
10cellular iron ion homeostasisGO:0068798.6SLC11A2, HFE, FTH1, FTL, CP, TF

Molecular functions related to Hemosiderosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ferroxidase activityGO:0043229.9FTH1, CP
2copper ion bindingGO:0055079.8SLC11A2, CP
3ferric iron bindingGO:0081999.4FTH1, FTL, TF
4iron ion bindingGO:0055068.9SLC11A2, FTH1, FTL
5receptor bindingGO:0051028.8MIF, CAT, CALCA, HFE
6protein bindingGO:0055156.5TF, EPO, FTL, FTH1, MIF, CALCA

Products for genes affiliated with Hemosiderosis

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Sources for Hemosiderosis

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3CDC
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25ICD10
26ICD10 via Orphanet
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