MCID: HMS001
MIFTS: 55

Hemosiderosis malady

Rare diseases category

Summaries for Hemosiderosis

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Sources:
9Disease Ontology, 66Wikipedia, 34MalaCards
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Disease Ontology:9 An iron metabolism disease that has material basis in an accumulation of hemosiderin, an iron-storage complex, resulting in iron overload.

MalaCards: Hemosiderosis, also known as haemosiderosis, is related to hemochromatosis and hepatitis. An important gene associated with Hemosiderosis is CP (ceruloplasmin (ferroxidase)), and among its related pathways are Metal ion SLC transporters and HIF-2-alpha transcription factor network. The drug cyclophosphamide and the compounds ferric oxide and recormon have been mentioned in the context of this disorder. Affiliated tissues include liver, lung and heart, and related mouse phenotypes are liver/biliary system and immune system.

Wikipedia:66 Hemosiderosis (AmE) or haemosiderosis (BrE) is a form of iron overload disorder resulting in the... more...

Aliases & Classifications for Hemosiderosis

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Sources:
9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 46Novoseek, 63UMLS, 59SNOMED-CT, 41NCIt, 36MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Aliases & Descriptions:

hemosiderosis 9 44 11 46 63
haemosiderosis 9


External Ids:

Disease Ontology9 DOID:12119
NCIt41 C82892
SNOMED-CT59 39011001, 190849009
MeSH36 D006486

Related Diseases for Hemosiderosis

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Hemosiderosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 156)
idRelated DiseaseScoreTop Affiliating Genes
1hemochromatosis30.9CP, HFE, SLC11A2, TF
2hepatitis30.9HFE, CP, CAT
3iron deficiency anemia30.5TF, EPO, HFE, SLC11A2
4aceruloplasminemia30.5CP
5beta thalassemia30.3TF, HFE
6deficiency anemia30.2FTL, TF, EPO, FTH1, MIF, HFE
7hemolytic anemia30.2HFE, EPO, TF, CP
8sickle cell disease30.1EPO, TF
9arthritis30.1MIF, CALCA, HFE, FTL, FTH1
10tuberculosis30.1CP, MIF, SLC11A2
11siderosis30.0HFE, TF, CP, FTL, FTH1
12porphyria29.9TF, HFE
13pneumoconiosis29.9CP, CAT
14liver cirrhosis29.9CP, TF, HFE
15microcytic anemia29.9TF, SLC11A2, EPO
16hepatitis c29.9SLC11A2, HFE, TF
17rheumatoid arthritis29.9HFE, CP, MIF
18diabetes mellitus29.8TF, FTH1, FTL, CP, HFE, CAT
19porphyria cutanea tarda29.8HFE, TF, FTL, FTH1
20vascular disease29.8TF, FTL, CAT, FTH1
21brown induration10.5
22celiac disease10.4
23thalassemia10.4
24cerebritis10.3
25glomerulonephritis10.2
26pulmonary function10.2
27hfe-associated hereditary hemochromatosis10.1HFE
28sickle cell anemia10.1
29rheumatic heart disease10.1
30cerebral amyloid angiopathy10.1
31hemoglobinuria10.1
32hypertension10.1
33paroxysmal nocturnal hemoglobinuria10.1
34secondary pulmonary hemosiderosis10.1
35metanephric adenoma10.1KRT7
36pityriasis versicolor10.1CAT
37bantu siderosis10.1HFE, TF
38iron metabolism disease10.1HFE, TF
39pancytopenia10.1CP, EPO
40alcohol abuse10.1TF, HFE
41schimke immunoosseous dysplasia10.1HFE, CP
42malaria10.1MIF, CP
43hemoglobinopathy10.1HFE, EPO, TF
44hypochromic microcytic anemia10.1CP, SLC11A2, TF
45adult respiratory distress syndrome10.1TF, MIF
46secondary hyperparathyroidism of renal origin10.1EPO, CALCA
47factor v leiden thrombophilia10.1EPO, HFE, CP
48myelodysplastic syndromes10.1EPO, TF, HFE
49nutritional deficiency disease10.1FTL, FTH1
50vitamin b12 deficiency10.0FTH1, FTL

Graphical network of the top 20 diseases related to Hemosiderosis:



Diseases related to hemosiderosis

Symptoms for Hemosiderosis

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Drugs & Therapeutics for Hemosiderosis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Hemosiderosis

Drug clinical trials:

Search ClinicalTrials for Hemosiderosis

Search NIH Clinical Center for Hemosiderosis

Search CenterWatch for Hemosiderosis

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Hemosiderosis

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Anatomical Context for Hemosiderosis

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Sources:
34MalaCards
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MalaCards organs/tissues related to Hemosiderosis:

34
Liver, Lung, Heart, Kidney, Spleen, Bone, Testes, Bone marrow, Pancreas, Endothelial, Placenta, Lymph node, Brain, Skin

Animal Models for Hemosiderosis or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Hemosiderosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.8CP, EPO, FTH1, HFE, SLC11A2
2MP:00053878.3SLC11A2, HFE, MIF, FTH1, CP, IGHE
3MP:00053977.7TF, IGHE, CP, EPO, FTH1, MIF
4MP:00107687.5TF, EPO, FTH1, CAT, CALCA, HFE
5MP:00053847.4CP, EPO, FTH1, MIF, CAT, HFE
6MP:00053766.7SLC11A2, TF, IGHE, CP, EPO, FTH1

Publications for Hemosiderosis

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Sources:
53PubMed
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Articles related to Hemosiderosis:

(show top 50)    (show all 448)
idTitleAuthorsYear
1
A case report of hemosiderosis-induced ventricular pacing exit block. (23907043)
2013
2
Child with idiopathic pulmonary hemosiderosis: a case report from Pakistan with multiple ethical and moral issues. (21968218)
2012
3
Idiopathic pulmonary hemosiderosis: alveoli are an answer to anemia. (21206122)
2011
4
Idiopathic pulmonary hemosiderosis in a 9-year-old girl. (20156739)
2009
5
Sequential antiviral and iron chelation treatment in a teenage boy with congenital anemia, chronic hepatitis C, and secondary hemosiderosis. (19274798)
2009
6
A pilot MRI study of organ specific hemosiderosis and functional correlation in Chinese patients with myelodysplasia and aplastic anemia with raised ferritin levels. (18484675)
2008
7
Longitudinal analysis of hearing loss in a case of hemosiderosis of the central nervous system. (14501449)
2003
8
Idiopathic pulmonary hemosiderosis in a child: report of one case. (11355061)
2001
9
Antioxidant therapy of cobalt and vitamin E in hemosiderosis. (9708577)
1998
10
Pulmonary hemosiderosis and immune complex glomerulonephritis. (7634551)
1995
11
Decrease in serum ferritin level in a patient with HCV hepatitis and liver hemosiderosis by interferon-alpha. (7769377)
1994
12
Superficial hemosiderosis of the central nervous system. A case report. (7992663)
1994
13
Renal hemosiderosis due to thalassemia: a light and electron microscopy study with electron probe X-ray microanalysis. (8316965)
1993
14
Long-term prednisolone therapy in children with idiopathic pulmonary hemosiderosis. (8443057)
1993
15
Diagnosis of pulmonary hemosiderosis by MR imaging. (2783811)
1989
16
Hemosiderosis and hemochromatosis in renal transplant recipients. Clinical and pathological features, diagnostic correlations, predisposing factors, and treatment. (3909817)
1985
17
Complete break in the wall of the capillary in idiopathic pulmonary hemosiderosis. (6464214)
1984
18
Increased IgD milk antibody responses in a patient with Down's syndrome, pulmonary hemosiderosis and cor pulmonale. (6226218)
1983
19
Hemosiderosis in a dialysis patient: treatment with hemofiltration and deferoxamine chelation therapy. (7087549)
1982
20
Experimental hemosiderosis: relationship between skin pigmentation and hemosiderin. (6155014)
1980
21
Nuclear scan of pulmonary hemorrhage in idiopathic pulmonary hemosiderosis. (103389)
1979
22
Iron metabolism and chelation therapy in hemosiderosis. (400529)
1978
23
Idiopathic pulmonary hemosiderosis. (642604)
1978
24
Localized hemosiderosis as a sequela of acne. (152613)
1978
25
Hemosiderosis secondary to chronic parenteral iron therapy in maintenance hemodialysis patients. (740092)
1978
26
Asymptomatic IgA nephropathy associated with pulmonary hemosiderosis. (350044)
1978
27
Renal amyloidosis with nephrotic syndrome in a child suspected of having idiopathic pulmonary hemosiderosis. (617983)
1977
28
Hyperreactivity to cow milk in young children with pulmonary hemosiderosis and cor pulmonale secondary to nasopharyngeal obstruction. (1173819)
1975
29
Idiopathic pulmonary hemosiderosis with manifestations of multiple connective tissue and immune disorders. Treatment with cyclophosphamide. (4544643)
1974
30
Effects of cyclic starvation-feeding and of splenectomy on the development of hemosiderosis in rat livers. (4814898)
1974
31
Letter: Idiopathic pulmonary hemosiderosis. (4414263)
1974
32
Complete left bundle branch block in idiopathic pulmonary hemosiderosis. (4421798)
1974
33
Idiopathic pulmonary hemosiderosis. Case report with pulmonary function tests and cardiac catheterization data. (4641225)
1972
34
Megaloblastic anemia associated with parenchymal hemosiderosis. (5231720)
1967
35
Renal hemosiderosis in patients with prosthetic aortic valves. (5904416)
1966
36
Idiopathic pulmonary hemosiderosis: case report of adult with long survival. (5833288)
1965
37
IDIOPATHIC PULMONARY HEMOSIDEROSIS ASSOCIATED WITH RENAL CHANGES AND ABNORMAL SERUM PROTEINS: REPORT OF A CASE. (14333658)
1965
38
IDIOPATHIC PULMONARY HEMOSIDEROSIS. (14215918)
1964
39
NODULAR ASPIRATIONAL PULMONARY HEMOSIDEROSIS. (14217076)
1964
40
Idiopathic pulmonary hemosiderosis in adults. Report of case and review of literature. (13939601)
1963
41
Pulmonary hemosiderosis and glomerulonephritis. (14496477)
1962
42
Pulmonary hemosiderosis with glomerulonephritis. A report of two cases. (13760442)
1961
43
Idiopathic pulmonary hemosiderosis. (13787318)
1960
44
Renal hemosiderosis in the hemolytic anemias: diagnosis by means of needle biopsy. (14415802)
1960
45
The nature of storage iron in idiopathic hemochromatosis and in hemosiderosis. Electron optical, chemical, and serologic studies on isolated hemosiderin granules. (13741389)
1960
46
Study on essential pulmonary hemosiderosis]. (13621512)
1958
47
Neuropathy, cardiopathy, hemosiderosis, and testicular atrophy in Gorilla gorilla. (13217581)
1955
48
Idiopathic pulmonary hemosiderosis. (13155826)
1954
49
Idiopathic pulmonary hemosiderosis (essential brown induration of the lungs). (14783612)
1950
50
Hemosiderosis of the lung due to mitral disease; a report of six cases simulating pneumoconiosis. (18120450)
1949

Variations for Hemosiderosis

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Expression for genes affiliated with Hemosiderosis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hemosiderosis

Search GEO for disease gene expression data for Hemosiderosis.

Pathways for genes affiliated with Hemosiderosis

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Sources:
51PathCards, 56Reactome, 39NCBI BioSystems Database, 31KEGG
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Pathways related to Hemosiderosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8CP, SLC11A2
29.8EPO, SLC11A2
39.6TF, EPO, CP
49.4TF, SLC11A2, FTH1
5
Show member pathways
tetrapyrrole biosynthesis39
heme degradation39
Heme Biosynthesis39
heme biosynthesis39
heme biosynthesis from uroporphyrinogen-III I39
9.3CP, FTH1, FTL
68.9SLC11A2, FTH1, TF, FTL
7
Show member pathways
8.6FTH1, SLC11A2, TF, FTL, CP
8
Show member pathways
8.6SLC11A2, FTL, CP, TF, FTH1

Compounds for genes affiliated with Hemosiderosis

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Sources:
46Novoseek, 12DrugBank, 25HMDB, 30IUPHAR, 52PharmGKB, 62Tocris Bioscience, 3BitterDB
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Compounds related to Hemosiderosis according to GeneCards/GeneDecks:

(show top 50)    (show all 95)
idCompoundScoreTop Affiliating Genes
1ferric oxide4610.2CP, EPO
2recormon4610.1EPO, TF
3ferric gluconate4610.1EPO, TF
4ferrihydrite4610.1FTH1, CP
5ferrous ammonium sulfate4610.0TF, CP, FTH1
6apotransferrin469.9TF, FTH1, CP
7deferiprone469.9EPO, TF
8ferrozine469.8FTL, TF, CP
9nandrolone decanoate46 1210.8CALCA, EPO, TF
10dmpo-oh469.7CAT, CP
11protoporphyrin ix46 25 1211.7TF, EPO, FTL
12haem469.6HFE, SLC11A2, FTL
13dehydroascorbic acid46 1210.6TF, CP, CAT
14dtpa469.6TF, CP, CAT
15tocopherol469.6CAT, CP, TF
16iron dextran46 1210.4TF, EPO, FTL, FTH1
17glibenclamide46 30 52 6212.3MIF, CP, CALCA
18vitamin b12469.3TF, CP, EPO
19citrate469.2CP, TF, SLC11A2, CAT
20thyroxine46 2510.2TF, CP, CALCA, IGHE
21ferric ammonium citrate469.2TF, CP, FTL, CAT
22selenium46 2510.2CAT, TF, CP
23epinephrine46 25 1211.1CALCA, CP, IGHE, TF
24fe3+469.1FTH1, FTL, CP, TF, SLC11A2
25aspartate469.1TF, EPO, HFE, CP, IGHE
26mannitol46 1210.1IGHE, CP, CAT, FTH1
27folate469.0IGHE, EPO, FTL, TF, CP
28cholesterol46 30 25 1211.9SLC11A2, TF, HFE, FTL, CP
29hydrocortisone46 3 62 1211.9IGHE, EPO, MIF, CALCA, TF
30fenton468.9CP, TF, CAT, FTL, EPO
31carbohydrates468.9TF, IGHE, CP, KRT7
32methotrexate52 46 1210.8TF, IGHE, EPO, KRT7
33sialic acid468.8CP, TF, KRT7, MIF, EPO
34n acetylcysteine468.7SLC11A2, CAT, IGHE, TF
35fe2+468.7HFE, CAT, CP, TF, SLC11A2, FTH1
36copper46 259.7SLC11A2, HFE, CAT, TF, FTH1, CP
37indomethacin46 30 62 1211.7CAT, CALCA, CP, IGHE
38zinc46 259.6SLC11A2, HFE, MIF, FTH1, CP, FTL
39creatinine468.6IGHE, CALCA, EPO, CP, TF, MIF
40deferoxamine46 129.5CP, CAT, TF, FTH1, FTL, EPO
41h2o2468.5CAT, MIF, FTH1, FTL, CP
42oxygen46 259.3MIF, CAT, CP, EPO, FTL, FTH1
43vitamin a46 25 1210.3TF, CP, CAT, KRT7, IGHE
44testosterone46 62 25 1211.2EPO, CP, CALCA, KRT7, IGHE, HFE
45lactate468.0TF, MIF, CALCA, CAT, IGHE, CP
46ascorbic acid46 258.9EPO, CP, IGHE, TF, SLC11A2, HFE
47vegf467.8IGHE, CP, EPO, MIF, CALCA, TF
48estrogen467.8TF, IGHE, CP, MIF, KRT7, HFE
49lipid467.6KRT7, HFE, CAT, MIF, FTH1, FTL
50iron46 258.1CP, SLC11A2, TF, KRT7, EPO, FTL

GO Terms for genes affiliated with Hemosiderosis

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17Gene Ontology
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Cellular components related to Hemosiderosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intracellular ferritin complexGO:0080439.8FTH1, FTL
2basal part of cellGO:0451789.7SLC11A2, HFE, TF
3recycling endosomeGO:0550379.6TF, HFE, SLC11A2
4early endosomeGO:0057699.2TF, HFE, SLC11A2
5cell surfaceGO:0099869.1TF, EPO, MIF, SLC11A2
6extracellular spaceGO:0056158.6CALCA, MIF, EPO, CP, TF
7extracellular vesicular exosomeGO:0700628.6MIF, FTH1, FTL, CP, TF
8extracellular regionGO:0055768.3TF, IGHE, CP, EPO, MIF, CALCA

Biological processes related to Hemosiderosis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1multicellular organismal iron ion homeostasisGO:06058610.0HFE, SLC11A2
2negative regulation of calcium ion transport into cytosolGO:0105239.9CALCA, EPO
3copper ion transportGO:0068259.8SLC11A2, CP
4iron ion transportGO:0068269.7FTH1, FTL
5embryo implantationGO:0075669.6EPO, CALCA
6response to hyperoxiaGO:0550939.6CAT, EPO
7immune responseGO:0069559.3HFE, FTH1, IGHE
8post-Golgi vesicle-mediated transportGO:0068929.3FTH1, FTL
9transmembrane transportGO:0550858.8TF, CP, FTL, FTH1, SLC11A2
10cellular iron ion homeostasisGO:0068798.6SLC11A2, HFE, FTH1, FTL, CP, TF

Molecular functions related to Hemosiderosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ferroxidase activityGO:0043229.9FTH1, CP
2copper ion bindingGO:0055079.8SLC11A2, CP
3ferric iron bindingGO:0081999.4FTH1, FTL, TF
4iron ion bindingGO:0055068.9SLC11A2, FTH1, FTL
5receptor bindingGO:0051028.8MIF, CAT, CALCA, HFE
6protein bindingGO:0055156.5TF, EPO, FTL, FTH1, MIF, CALCA

Products for genes affiliated with Hemosiderosis

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  • Antibodies
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Sources for Hemosiderosis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet