MCID: HMS001
MIFTS: 52

Hemosiderosis malady

Summaries for Hemosiderosis

About this section
Sources:
8Disease Ontology, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Disease Ontology:8 An iron metabolism disease that has material basis in an accumulation of hemosiderin, an iron-storage complex, resulting in iron overload.

MalaCards: Hemosiderosis, also known as haemosiderosis, is related to hemochromatosis and hepatitis. An important gene associated with Hemosiderosis is CP (ceruloplasmin (ferroxidase)), and among its related pathways are Scavenging by Class A Receptors and HIF-1-alpha transcription factor network. The drug cyclophosphamide and the compounds recormon and ferric gluconate have been mentioned in the context of this disorder. Affiliated tissues include liver, lung and heart, and related mouse phenotypes are homeostasis/metabolism and cellular.

Wikipedia:63 Hemosiderosis (AmE) or haemosiderosis (BrE) is a form of iron overload disorder resulting in the... more...

Aliases & Classifications for Hemosiderosis

About this section
Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH
See all sources

Aliases & Descriptions:

hemosiderosis 8 42 10 44 60
haemosiderosis 8


External Ids:

Disease Ontology8 DOID:12119
NCIt39 C82892
SNOMED-CT56 190849009, 39011001
MeSH34 D006486

Related Diseases for Hemosiderosis

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Hemosiderosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 180)
idRelated DiseaseScoreTop Affiliating Genes
1hemochromatosis30.7CP, SLC11A2, HFE, TF
2hepatitis30.7CP, HFE, CAT
3celiac disease30.5HFE
4iron deficiency anemia30.3TF, HFE, EPO, SLC11A2
5deficiency anemia30.3TF, PIGA, HFE, MIF, FTL, FTH1
6glomerulonephritis30.3CAT, MIF
7aceruloplasminemia30.2CP
8hypertension30.1CALCA
9beta thalassemia30.1HFE, TF
10hemolytic anemia30.1TF, PIGA, HFE, EPO, CP
11arthritis30.1CALCA, HFE, MIF, FTL, FTH1
12cystic fibrosis29.9CP
13sickle cell disease29.9EPO, TF
14hepatitis b29.9MIF, HFE
15microcytic anemia29.9TF, EPO, SLC11A2
16rheumatoid arthritis29.9CP, MIF, HFE
17hepatitis c29.9SLC11A2, HFE, TF
18liver cirrhosis29.9TF, HFE, SLC11A2, CP
19siderosis29.9TF, HFE, FTL, FTH1, CP
20diabetes mellitus29.9CALCA, CAT, TF, HFE, FTL, FTH1
21tuberculosis29.9MIF, SLC11A2, CP
22viral hepatitis29.7HFE
23nephrotic syndrome29.7TF
24dementia29.7CP
25adenocarcinoma29.7KRT7
26porphyria29.7TF, HFE
27meningitis29.7CAT
28acute leukemia29.7HFE, EPO
29neuropathy29.7CALCA
30pneumoconiosis29.7CP, CAT
31hypochromic microcytic anemia29.7TF, SLC11A2, CP
32thrombocytopenia29.7PIGA, HFE, EPO
33cataract29.7FTL, CAT
34leukemia29.7CAT, PIGA, HFE, EPO
35porphyria cutanea tarda29.7FTH1, FTL, HFE, TF
36vascular disease29.7FTH1, FTL, TF, CAT
37brown induration10.4
38hepatitis a10.3
39thalassemia10.3
40cerebritis10.2
41sickle cell anemia10.1
42hemoglobinuria10.1
43cerebral amyloid angiopathy10.1
44pulmonary fibrosis10.1
45gaucher's disease10.0
46systemic lupus erythematosus10.0
47hypochromic anemia10.0
48alcoholic hepatitis10.0
49hemorrhagic disease10.0
50kidney disease10.0

Graphical network of the top 20 diseases related to Hemosiderosis:



Diseases related to hemosiderosis

Clinical Features for Hemosiderosis

About this section

Drugs & Therapeutics for Hemosiderosis

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Hemosiderosis

Drug clinical trials:

Search ClinicalTrials for Hemosiderosis

Search NIH Clinical Center for Hemosiderosis

Search CenterWatch for Hemosiderosis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Hemosiderosis

About this section

Anatomical Context for Hemosiderosis

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Hemosiderosis:

32
Liver, Lung, Heart, Kidney, Spleen, Pancreas, Bone marrow, Testes, Bone, Lymph node, Brain, Endothelial, Skin, Placenta

Animal Models for Hemosiderosis or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Hemosiderosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.3CALCA, TF, HFE, IGHE, EHD1, FTH1
2MP:00053847.1PIGA, EHD1, MIF, FTH1, EPO, KRT7
3MP:00053976.9CP, TF, PIGA, HFE, IGHE, EHD1
4MP:00107686.9CALCA, CAT, TF, PIGA, HFE, EHD1

Publications for Hemosiderosis

About this section
Sources:
50PubMed
See all sources

Articles related to Hemosiderosis:

(show top 50)    (show all 451)
idTitleAuthorsYear
1
Sequential antiviral and iron chelation treatment in a teenage boy with congenital anemia, chronic hepatitis C, and secondary hemosiderosis. (19274798)
2009
2
A case of congenital agenesis of the right pulmonary artery presenting with hemoptysis and mimicking pulmonary hemosiderosis. (18478262)
2009
3
Patient-reported outcomes of deferasirox (Exjade, ICL670) versus deferoxamine in sickle cell disease patients with transfusional hemosiderosis. Substudy of a randomized open-label phase II trial. (18408362)
2008
4
Donor affected by hemosiderosis: is kidney transplantation possible? A case report. (18675062)
2008
5
The endoscopic appearance of focal gastric hemosiderosis as a brown macular patch resembling that of cutaneous iron deposition in hemochromatosis. (18184134)
2008
6
Idiopathic pulmonary hemosiderosis in an adult patient responded well to corticosteroid therapy. (17401798)
2007
7
Idiopathic pulmonary hemosiderosis. (11519298)
2001
8
Pulmonary hemosiderosis with juvenile rheumatoid arthritis: a case report. (10936982)
2000
9
Frequency of pulmonary hemosiderosis in Eastern North Carolina. (10739224)
2000
10
A case of hereditary ceruloplasmin deficiency with hemosiderosis]. (10391079)
1999
11
Isolation of Stachybotrys from the lung of a child with pulmonary hemosiderosis. (10506242)
1999
12
Long-term clinical course of patients with idiopathic pulmonary hemosiderosis (1979-1994): prolonged survival with low-dose corticosteroid therapy. (10213256)
1999
13
Microvesicular steatosis, hemosiderosis and rapid development of liver cirrhosis in a patient with Pearson's syndrome. (10488717)
1999
14
Antioxidant therapy of cobalt and vitamin E in hemosiderosis. (9708577)
1998
15
The challenges of idiopathic pulmonary hemosiderosis and lung transplantation. (9313410)
1997
16
Improvement of erythropoiesis during treatment with deferiprone in a patient with myelofibrosis and transfusional hemosiderosis. (8619408)
1996
17
The anesthetic and intensive care management of pulmonary hemosiderosis in a child--case report. (7476743)
1995
18
Computed tomography findings in idiopathic pulmonary hemosiderosis. (8469822)
1993
19
Transfusional hemosiderosis in sickle cell anemia: another cause of an echogenic pancreas. (8516039)
1993
20
MRI findings in renal cortical hemosiderosis. (1490450)
1992
21
Cow's milk-induced pulmonary hemosiderosis. (2769010)
1989
22
Idiopathic pulmonary hemosiderosis, complete heart block and celiac disease. (2731063)
1989
23
Treatment of a seven-year-old child with end-stage renal disease and hemosiderosis by recombinant human erythropoietin. (3391028)
1988
24
Idiopathic pulmonary hemosiderosis and related disorders in infancy and childhood. (3299251)
1987
25
Hemosiderosis and hemochromatosis in renal transplant recipients. Clinical and pathological features, diagnostic correlations, predisposing factors, and treatment. (3909817)
1985
26
Prognostic criteria in idiopathic pulmonary hemosiderosis in children. (6884388)
1983
27
Pulmonary hemosiderosis and immune thrombocytopenia. Initial manifestations of collagen-vascular disease. (7195946)
1981
28
An autopsy case of idiopathic pulmonary hemosiderosis. (752745)
1978
29
Idiopathic pulmonary hemosiderosis: evidence of capillary basement membrane abnormality. (970745)
1976
30
Hyperreactivity to cow milk in young children with pulmonary hemosiderosis and cor pulmonale secondary to nasopharyngeal obstruction. (1173819)
1975
31
Alveolar capillary basement membrane lesions in Goodpasture's syndrome and idiopathic pulmonary hemosiderosis. (1106191)
1975
32
Postoperative superficial hemosiderosis of the brain, its diagnosis, treatment and prevention. (4784920)
1973
33
Pulmonary function studies in idiopathic pulmonary hemosiderosis in children. (4690488)
1973
34
Idiopathic pulmonary hemosiderosis. Case report with pulmonary function tests and cardiac catheterization data. (4641225)
1972
35
Idiopathic pulmonary hemosiderosis. Case report with pulmonary function tests and review of the literature. (5657156)
1968
36
Retention of radioiron in the lungs of a woman with idiopathic pulmonary hemosiderosis. (5725735)
1968
37
Porphyria cutanea tarda in association with hemosiderosis of the liver. Iron absorption studies and evaluation of therapy by phlebotomy. (5677557)
1968
38
Hemosiderosis--hemochromatosis. A brief survey and a case report. (5978409)
1966
39
An autopsy case of idiopathic pulmonary hemosiderosis. (5976553)
1966
40
Pulmonary hemosiderosis and glomerular kidney disease: Goodpasture's syndrome. (5860863)
1965
41
GOODPASTURE'S SYNDROME: PULMONARY HEMOSIDEROSIS WITH GLOMERULONEPHRITIS. (14105018)
1964
42
RELATIONSHIP OF HEMOSIDEROSIS TO PORTACAVAL SHUNTING. (14087128)
1963
43
Idiopathic pulmonary hemorrhage with hemosiderosis and microcytic anemia. (13518528)
1958
44
Idiopathic pulmonary hemosiderosis. (13292446)
1956
45
Idiopathic pulmonary hemosiderosis; essential brown induration of the lung; report of a case and review of literature. (13319912)
1956
46
Hemosiderosis resembling hemochromatosis following multiple transfusions. (13258148)
1955
47
Erythrophagocytosis and hemosiderosis in lymph nodes, spleen and liver in patients dying of malignant hypertension, chronic glomerulonephritis and pyelonephritis and polycystic disease. (13125214)
1954
48
Essential pulmonary hemosiderosis. (14848134)
1951
49
Hemosiderosis of the lung due to mitral disease; a report of six cases simulating pneumoconiosis. (18120450)
1949
50
SIGNIFICANCE OF THE HEMOSIDEROSIS OF PERNICIOUS ANEMIA. (19868626)
1922

Genetic Variations for Hemosiderosis

About this section

Expression for genes affiliated with Hemosiderosis

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Hemosiderosis

Search GEO for disease gene expression data for Hemosiderosis.

Pathways for genes affiliated with Hemosiderosis

About this section
Sources:
53Reactome, 37NCBI BioSystems Database, 29KEGG
See all sources

Compounds for genes affiliated with Hemosiderosis

About this section
Sources:
44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Hemosiderosis according to GeneCards/GeneDecks:

(show top 50)    (show all 75)
idCompoundScoreTop Affiliating Genes
1recormon4410.3EPO, TF
2ferric gluconate4410.3EPO, TF
3ferric oxide4410.3EPO, CP
4fenton4410.3CP, FTL
5ferrihydrite4410.2FTH1, CP
6deferiprone4410.2TF, EPO
7iron sucrose4410.2TF, EPO
8ferrous ammonium sulfate4410.1TF, FTH1, CP
9apotransferrin4410.1CP, FTH1, TF
10dmpo-oh4410.1CP, CAT
11ferrozine4410.0TF, FTL, CP
12nandrolone decanoate44 1111.0EPO, TF, CALCA
13protoporphyrin ix44 11 2411.9TF, FTL, EPO
14dehydroascorbic acid44 1110.9CP, TF, CAT
15dtpa449.9CP, TF, CAT
16tocopherol449.9CAT, TF, CP
17haem449.9HFE, FTL, SLC11A2
18vitamin b12449.8TF, EPO, CP
19aspartate449.7HFE, IGHE, CP
20iron dextran44 1110.7TF, FTL, FTH1, EPO
21glibenclamide44 28 49 5912.7CALCA, MIF, CP
22oxygen44 2410.7EPO, FTH1, FTL
23vitamin a44 11 2411.7CP, IGHE, CAT
24aluminium44 1110.7EPO, TF
25selenium44 2410.6CP, TF, CAT
26mannitol44 1110.6FTH1, IGHE, CAT
27ferric ammonium citrate449.6CP, FTL, TF, CAT
28citrate449.6CAT, TF, SLC11A2, CP
29malondialdehyde449.5CP, EPO, CAT
30betacarotene449.4CAT, TF, CP
31thyroxine44 2410.4CALCA, TF, IGHE, CP
32fe3+449.4TF, FTL, FTH1, SLC11A2, CP
33cyclophosphamide44 49 1111.4TF, PIGA, IGHE, MIF
34folate449.2TF, IGHE, FTL, EPO, CP
35carbohydrates449.2TF, IGHE, KRT7, CP
36sialic acid449.2TF, MIF, EPO, KRT7, CP
37hydrocortisone44 2 59 1112.1CALCA, TF, IGHE, MIF, EPO
38fe2+449.1CP, SLC11A2, FTH1, HFE, TF, CAT
39copper44 2410.1CAT, TF, HFE, FTH1, SLC11A2, CP
40epinephrine44 11 2411.1CP, IGHE, TF, CALCA
41methotrexate44 49 1111.0KRT7, EPO, IGHE, TF
42deferoxamine44 1110.0CAT, TF, FTL, FTH1, EPO, CP
43zinc44 249.9HFE, MIF, FTL, FTH1, SLC11A2, CP
44creatinine448.9CALCA, TF, IGHE, MIF, EPO, CP
45testosterone44 59 11 2411.6CALCA, HFE, IGHE, EPO, KRT7, CP
46lactate448.4CALCA, CAT, TF, IGHE, MIF, EPO
47ascorbic acid44 249.3CAT, TF, HFE, IGHE, FTH1, EPO
48vegf448.3CALCA, TF, IGHE, MIF, EPO, KRT7
49lipid448.2CAT, HFE, MIF, FTL, FTH1, KRT7
50iron44 248.8CAT, TF, HFE, FTL, FTH1, EPO

GO Terms for genes affiliated with Hemosiderosis

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Hemosiderosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intracellular ferritin complexGO:0080439.8FTH1, FTL
2basal part of cellGO:0451789.7SLC11A2, HFE, TF
3recycling endosomeGO:0550379.6SLC11A2, HFE, TF
4early endosomeGO:0057699.4TF, HFE, SLC11A2
5extracellular regionGO:0055768.5CP, EPO, MIF, IGHE, TF, CALCA

Biological processes related to Hemosiderosis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of calcium ion transport into cytosolGO:0105239.9EPO, CALCA
2multicellular organismal iron ion homeostasisGO:0605869.9SLC11A2, HFE
3iron ion transportGO:0068269.8FTH1, FTL
4response to hyperoxiaGO:0550939.7CAT, EPO
5copper ion transportGO:0068259.6CP, SLC11A2
6transmembrane transportGO:0550859.0TF, FTL, FTH1, SLC11A2, CP
7cellular iron ion homeostasisGO:0068798.9CP, TF, HFE, FTL, FTH1, SLC11A2

Molecular functions related to Hemosiderosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ferroxidase activityGO:0043229.6FTH1, CP
2ferric iron bindingGO:0081999.5FTH1, FTL, TF
3receptor bindingGO:0051029.1MIF, HFE, CAT, CALCA
4protein bindingGO:0055155.6CALCA, TF, PIGA, HFE, ANKHD1, EHD1

Products for genes affiliated with Hemosiderosis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hemosiderosis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet