MCID: HMS001
MIFTS: 51

Hemosiderosis malady

Summaries for Hemosiderosis

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Disease Ontology:8 An iron metabolism disease that has material basis in an accumulation of hemosiderin, an iron-storage complex, resulting in iron overload.

MalaCards: Hemosiderosis, also known as haemosiderosis, is related to hemochromatosis and celiac disease. An important gene associated with Hemosiderosis is CP (ceruloplasmin (ferroxidase)), and among its related pathways are Scavenging by Class A Receptors and HIF-1-alpha transcription factor network. The drug cyclophosphamide and the compounds ferric gluconate and recormon have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and brain, and related mouse phenotypes are homeostasis/metabolism and cellular.

Wikipedia:64 Hemosiderosis (AmE) or haemosiderosis (BrE) is a form of iron overload disorder resulting in the... more...

Aliases & Classifications for Hemosiderosis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 40NCIt, 35MeSH
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Aliases & Descriptions:

hemosiderosis 8 43 10 45 61
haemosiderosis 8


External Ids:

Disease Ontology8 DOID:12119
NCIt40 C82892
SNOMED-CT57 190849009, 39011001
MeSH35 D006486

Related Diseases for Hemosiderosis

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Hemosiderosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 177)
idRelated DiseaseScoreTop Affiliating Genes
1hemochromatosis30.8CP, SLC11A2, HFE, TF
2celiac disease30.5HFE
3thalassemia30.5TF, HFE, FTL, FTH1, EPO, SLC11A2
4iron deficiency anemia30.4TF, HFE, EPO, SLC11A2
5deficiency anemia30.4TF, PIGA, HFE, MIF, FTL, FTH1
6aceruloplasminemia30.2CP
7beta thalassemia30.1HFE, TF
8arthritis30.1CALCA, HFE, MIF, FTL, FTH1
9cystic fibrosis30.0CP
10sickle cell disease30.0EPO, TF
11hepatitis c30.0SLC11A2, HFE, TF
12siderosis30.0TF, HFE, FTL, FTH1, CP
13tuberculosis29.9MIF, SLC11A2, CP
14viral hepatitis29.8HFE
15adenocarcinoma29.8KRT7
16acute leukemia29.8HFE, EPO
17hypochromic microcytic anemia29.8TF, SLC11A2, CP
18thrombocytopenia29.8PIGA, HFE, EPO
19urticaria29.8IGHE
20porphyria cutanea tarda29.7FTH1, FTL, HFE, TF
21vascular disease29.7FTH1, FTL, TF, CAT
22adenoma29.7CALCA, HFE, MIF, KRT7, CP
23brown induration10.5
24pulmonary function10.3
25good syndrome10.2
26goodpasture syndrome10.2
27secondary pulmonary hemosiderosis10.2
28hemoglobin d disease10.1
29sickle cell anemia10.1
30hemoglobinuria10.1
31cerebral amyloid angiopathy10.1
32hepatitis d10.1
33n syndrome10.1
34paroxysmal nocturnal hemoglobinuria10.1
35rheumatic disease10.1
36systemic lupus erythematosus10.0
37hypochromic anemia10.0
38hepatitis a10.0
39stachybotrys chartarum10.0
40refractory anemia10.0
41mitral valve prolapse10.0
42hepatic tuberculosis10.0
43cholelithiasis10.0
44aminoaciduria10.0
45coronary heart disease10.0HFE
46nephrotic syndrome10.0TF
47myocardial infarction10.0HFE
48schizophrenia10.0CP
49restless legs syndrome10.0TF
50obesity10.0HFE

Graphical network of the top 20 diseases related to Hemosiderosis:



Diseases related to hemosiderosis

Clinical Features for Hemosiderosis

Drugs & Therapeutics for Hemosiderosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Hemosiderosis

Drug clinical trials:

Search ClinicalTrials for Hemosiderosis

Search NIH Clinical Center for Hemosiderosis

Search CenterWatch for Hemosiderosis

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Hemosiderosis

Anatomical Context for Hemosiderosis

Sources:
33MalaCards
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MalaCards organs/tissues related to Hemosiderosis:

33
Skin, Liver, Brain, Kidney, Lymph node, Lung, Spleen, Bone marrow, Heart, Pancreas, Placenta, B cells, Endothelial, Fetal brain, Fetal liver, Fetal lung

Animal Models for Hemosiderosis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Hemosiderosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.3CALCA, TF, HFE, IGHE, EHD1, FTH1
2MP:00053847.1PIGA, EHD1, MIF, FTH1, EPO, KRT7
3MP:00053976.9CP, TF, PIGA, HFE, IGHE, EHD1
4MP:00107686.9CALCA, CAT, TF, PIGA, HFE, EHD1

Publications for Hemosiderosis

Sources:
51PubMed
See all sources

Articles related to Hemosiderosis:

(show top 50)    (show all 451)
idTitleAuthorsYear
1
Sequential antiviral and iron chelation treatment in a teenage boy with congenital anemia, chronic hepatitis C, and secondary hemosiderosis. (19274798)
2009
2
A case of congenital agenesis of the right pulmonary artery presenting with hemoptysis and mimicking pulmonary hemosiderosis. (18478262)
2009
3
Patient-reported outcomes of deferasirox (Exjade, ICL670) versus deferoxamine in sickle cell disease patients with transfusional hemosiderosis. Substudy of a randomized open-label phase II trial. (18408362)
2008
4
Donor affected by hemosiderosis: is kidney transplantation possible? A case report. (18675062)
2008
5
The endoscopic appearance of focal gastric hemosiderosis as a brown macular patch resembling that of cutaneous iron deposition in hemochromatosis. (18184134)
2008
6
Idiopathic pulmonary hemosiderosis in an adult patient responded well to corticosteroid therapy. (17401798)
2007
7
Idiopathic pulmonary hemosiderosis. (11519298)
2001
8
Pulmonary hemosiderosis with juvenile rheumatoid arthritis: a case report. (10936982)
2000
9
Frequency of pulmonary hemosiderosis in Eastern North Carolina. (10739224)
2000
10
A case of hereditary ceruloplasmin deficiency with hemosiderosis]. (10391079)
1999
11
Isolation of Stachybotrys from the lung of a child with pulmonary hemosiderosis. (10506242)
1999
12
Long-term clinical course of patients with idiopathic pulmonary hemosiderosis (1979-1994): prolonged survival with low-dose corticosteroid therapy. (10213256)
1999
13
Microvesicular steatosis, hemosiderosis and rapid development of liver cirrhosis in a patient with Pearson's syndrome. (10488717)
1999
14
Antioxidant therapy of cobalt and vitamin E in hemosiderosis. (9708577)
1998
15
The challenges of idiopathic pulmonary hemosiderosis and lung transplantation. (9313410)
1997
16
Improvement of erythropoiesis during treatment with deferiprone in a patient with myelofibrosis and transfusional hemosiderosis. (8619408)
1996
17
The anesthetic and intensive care management of pulmonary hemosiderosis in a child--case report. (7476743)
1995
18
Computed tomography findings in idiopathic pulmonary hemosiderosis. (8469822)
1993
19
Transfusional hemosiderosis in sickle cell anemia: another cause of an echogenic pancreas. (8516039)
1993
20
MRI findings in renal cortical hemosiderosis. (1490450)
1992
21
Cow's milk-induced pulmonary hemosiderosis. (2769010)
1989
22
Idiopathic pulmonary hemosiderosis, complete heart block and celiac disease. (2731063)
1989
23
Treatment of a seven-year-old child with end-stage renal disease and hemosiderosis by recombinant human erythropoietin. (3391028)
1988
24
Idiopathic pulmonary hemosiderosis and related disorders in infancy and childhood. (3299251)
1987
25
Hemosiderosis and hemochromatosis in renal transplant recipients. Clinical and pathological features, diagnostic correlations, predisposing factors, and treatment. (3909817)
1985
26
Prognostic criteria in idiopathic pulmonary hemosiderosis in children. (6884388)
1983
27
Pulmonary hemosiderosis and immune thrombocytopenia. Initial manifestations of collagen-vascular disease. (7195946)
1981
28
An autopsy case of idiopathic pulmonary hemosiderosis. (752745)
1978
29
Idiopathic pulmonary hemosiderosis: evidence of capillary basement membrane abnormality. (970745)
1976
30
Hyperreactivity to cow milk in young children with pulmonary hemosiderosis and cor pulmonale secondary to nasopharyngeal obstruction. (1173819)
1975
31
Alveolar capillary basement membrane lesions in Goodpasture's syndrome and idiopathic pulmonary hemosiderosis. (1106191)
1975
32
Postoperative superficial hemosiderosis of the brain, its diagnosis, treatment and prevention. (4784920)
1973
33
Pulmonary function studies in idiopathic pulmonary hemosiderosis in children. (4690488)
1973
34
Idiopathic pulmonary hemosiderosis. Case report with pulmonary function tests and cardiac catheterization data. (4641225)
1972
35
Idiopathic pulmonary hemosiderosis. Case report with pulmonary function tests and review of the literature. (5657156)
1968
36
Retention of radioiron in the lungs of a woman with idiopathic pulmonary hemosiderosis. (5725735)
1968
37
Porphyria cutanea tarda in association with hemosiderosis of the liver. Iron absorption studies and evaluation of therapy by phlebotomy. (5677557)
1968
38
Hemosiderosis--hemochromatosis. A brief survey and a case report. (5978409)
1966
39
An autopsy case of idiopathic pulmonary hemosiderosis. (5976553)
1966
40
Pulmonary hemosiderosis and glomerular kidney disease: Goodpasture's syndrome. (5860863)
1965
41
GOODPASTURE'S SYNDROME: PULMONARY HEMOSIDEROSIS WITH GLOMERULONEPHRITIS. (14105018)
1964
42
RELATIONSHIP OF HEMOSIDEROSIS TO PORTACAVAL SHUNTING. (14087128)
1963
43
Idiopathic pulmonary hemorrhage with hemosiderosis and microcytic anemia. (13518528)
1958
44
Idiopathic pulmonary hemosiderosis. (13292446)
1956
45
Idiopathic pulmonary hemosiderosis; essential brown induration of the lung; report of a case and review of literature. (13319912)
1956
46
Hemosiderosis resembling hemochromatosis following multiple transfusions. (13258148)
1955
47
Erythrophagocytosis and hemosiderosis in lymph nodes, spleen and liver in patients dying of malignant hypertension, chronic glomerulonephritis and pyelonephritis and polycystic disease. (13125214)
1954
48
Essential pulmonary hemosiderosis. (14848134)
1951
49
Hemosiderosis of the lung due to mitral disease; a report of six cases simulating pneumoconiosis. (18120450)
1949
50
SIGNIFICANCE OF THE HEMOSIDEROSIS OF PERNICIOUS ANEMIA. (19868626)
1922

Genetic Variations for Hemosiderosis

Expression for genes affiliated with Hemosiderosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hemosiderosis

Search GEO for disease gene expression data for Hemosiderosis.

Pathways for genes affiliated with Hemosiderosis

Sources:
54Reactome, 38NCBI BioSystems Database, 30KEGG
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Compounds for genes affiliated with Hemosiderosis

Sources:
45Novoseek, 11DrugBank, 24HMDB, 29IUPHAR, 50PharmGKB, 60Tocris Bioscience, 2BitterDB
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Compounds related to Hemosiderosis according to GeneCards/GeneDecks:

(show top 50)    (show all 75)
idCompoundScoreTop Affiliating Genes
1ferric gluconate4510.3EPO, TF
2recormon4510.3TF, EPO
3fenton4510.3FTL, CP
4ferric oxide4510.3EPO, CP
5ferrihydrite4510.2CP, FTH1
6deferiprone4510.2TF, EPO
7iron sucrose4510.2TF, EPO
8ferrous ammonium sulfate4510.1FTH1, TF, CP
9apotransferrin4510.1FTH1, CP, TF
10dmpo-oh4510.1CP, CAT
11ferrozine4510.0TF, FTL, CP
12nandrolone decanoate45 1111.0EPO, TF, CALCA
13protoporphyrin ix45 11 2411.9FTL, EPO, TF
14dehydroascorbic acid45 1110.9CP, CAT, TF
15dtpa459.9TF, CP, CAT
16tocopherol459.9CP, TF, CAT
17haem459.9SLC11A2, FTL, HFE
18vitamin b12459.8TF, EPO, CP
19aspartate459.7HFE, IGHE, CP
20iron dextran45 1110.7EPO, TF, FTL, FTH1
21glibenclamide45 29 50 6012.7CALCA, MIF, CP
22oxygen45 2410.7FTL, FTH1, EPO
23vitamin a45 11 2411.7CP, IGHE, CAT
24aluminium45 1110.7TF, EPO
25selenium45 2410.6CAT, TF, CP
26mannitol45 1110.6FTH1, IGHE, CAT
27ferric ammonium citrate459.6FTL, TF, CP, CAT
28citrate459.6TF, CP, CAT, SLC11A2
29malondialdehyde459.5EPO, CP, CAT
30betacarotene459.4CAT, CP, TF
31thyroxine45 2410.4CALCA, TF, CP, IGHE
32fe3+459.4FTL, CP, SLC11A2, FTH1, TF
33cyclophosphamide45 50 1111.4MIF, IGHE, PIGA, TF
34folate459.2CP, FTL, TF, IGHE, EPO
35carbohydrates459.2KRT7, IGHE, TF, CP
36sialic acid459.2KRT7, TF, MIF, EPO, CP
37hydrocortisone45 2 60 1112.1EPO, CALCA, IGHE, TF, MIF
38fe2+459.1SLC11A2, HFE, CP, FTH1, CAT, TF
39copper45 2410.1FTH1, CAT, SLC11A2, CP, TF, HFE
40epinephrine45 11 2411.1CALCA, TF, IGHE, CP
41methotrexate45 50 1111.0KRT7, TF, EPO, IGHE
42deferoxamine45 1110.0FTL, CAT, FTH1, TF, CP, EPO
43zinc45 249.9CP, SLC11A2, HFE, FTH1, FTL, MIF
44creatinine458.9TF, CALCA, IGHE, MIF, EPO, CP
45testosterone45 60 11 2411.6KRT7, CALCA, EPO, IGHE, CP, HFE
46lactate458.4CAT, CP, EPO, MIF, TF, IGHE
47ascorbic acid45 249.3CP, SLC11A2, IGHE, HFE, TF, CAT
48vegf458.3CP, CALCA, IGHE, MIF, EPO, KRT7
49lipid458.2FTH1, MIF, HFE, FTL, CAT, KRT7
50iron45 248.8TF, KRT7, SLC11A2, EPO, FTH1, FTL

GO Terms for genes affiliated with Hemosiderosis

Sources:
16Gene Ontology
See all sources

Cellular components related to Hemosiderosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intracellular ferritin complexGO:0080439.8FTL, FTH1
2basal part of cellGO:0451789.7TF, HFE, SLC11A2
3recycling endosomeGO:0550379.6TF, HFE, SLC11A2
4early endosomeGO:0057699.4TF, HFE, SLC11A2
5extracellular regionGO:0055768.5CALCA, TF, IGHE, MIF, EPO, CP

Biological processes related to Hemosiderosis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of calcium ion transport into cytosolGO:0105239.9EPO, CALCA
2multicellular organismal iron ion homeostasisGO:0605869.9SLC11A2, HFE
3iron ion transportGO:0068269.8FTH1, FTL
4response to hyperoxiaGO:0550939.7CAT, EPO
5copper ion transportGO:0068259.6CP, SLC11A2
6transmembrane transportGO:0550859.0TF, FTL, FTH1, SLC11A2, CP
7cellular iron ion homeostasisGO:0068798.9CP, TF, HFE, FTL, FTH1, SLC11A2

Molecular functions related to Hemosiderosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ferroxidase activityGO:0043229.6FTH1, CP
2ferric iron bindingGO:0081999.5TF, FTL, FTH1
3receptor bindingGO:0051029.1HFE, MIF, CALCA, CAT
4protein bindingGO:0055155.6EHD1, ANKHD1, HFE, PIGA, TF, CALCA

Products for genes affiliated with Hemosiderosis

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Sources for Hemosiderosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet