HAT
MCID: HPR003
MIFTS: 53

Heparin-Induced Thrombocytopenia (HAT) malady

Rare diseases, Blood diseases categories

Summaries for Heparin-Induced Thrombocytopenia

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44NIH Rare Diseases, 66Wikipedia, 34MalaCards
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NIH Rare Diseases:44 Heparin-induced thrombocytopenia (hit) is an adverse reaction to the drug heparin resulting in an abnormally low amount of platelets (thrombocytopenia). hit is usually an immune response which typically occurs 4-10 days after exposure to heparin; it can lead to serious complications and be life-threatening. this condition occurs in up to 5% of those who are exposed to heparin. characteristic signs of hit are a drop in platelet count of  greater than 50% and/or the formation of new blood clots during heparin therapy.  the first step of treatment is to discontinue and avoid all heparin products immediately. often, affected individuals require another medicine to prevent blood clotting (anticoagulants). last updated: 5/3/2012

MalaCards: Heparin-Induced Thrombocytopenia, also known as hit, is related to thrombocytopenia and pulmonary embolism. An important gene associated with Heparin-Induced Thrombocytopenia is F3 (coagulation factor III (thromboplastin, tissue factor)), and among its related pathways are Collagen biosynthesis and modifying enzymes and Complement and coagulation cascades. The compounds celite and roxifiban have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and liver, and related mouse phenotypes are cardiovascular system and hematopoietic system.

Wikipedia:66 Heparin-induced thrombocytopenia (HIT) is the development of thrombocytopenia (a low platelet count),... more...

Aliases & Classifications for Heparin-Induced Thrombocytopenia

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44NIH Rare Diseases, 50Orphanet, 63UMLS, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Blood diseases


Characteristics (Orphanet epidemiological data):

50
heparin-induced thrombocytopenia:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

heparin-induced thrombocytopenia 44 50 63
hit 44 50
heparin-induced thrombocytopenia type 2 50
heparin-associated thrombocytopenia 50
hat 50


External Ids:

ICD10 via Orphanet27 D69.5
SNOMED-CT via Orphanet60 73397007
UMLS via Orphanet64 C0272285

Related Diseases for Heparin-Induced Thrombocytopenia

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Heparin-Induced Thrombocytopenia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 106)
idRelated DiseaseScoreTop Affiliating Genes
1thrombocytopenia32.1CD40LG, F3, SERPINC1, FCGR2A, F10, GP1BA
2pulmonary embolism31.0F3, SERPINC1, F10
3thromboembolism31.0F10, SERPINC1, F3
4venous thrombosis30.8F10, FCGR2A, SERPINC1, F3
5antiphospholipid syndrome30.7CD40LG, F3, SERPINC1, F10
6coronary thrombosis30.7SERPINC1, F3
7myocardial infarction30.6GP1BA, F10, SERPINC1, F3
8sagittal sinus thrombosis30.6SERPINC1
9acute myocardial infarction30.6F10, SERPINC1, F3
10lupus erythematosus30.6SERPINC1, F3, CD40LG
11systemic lupus erythematosus30.5CD40LG, F3, FCGR2A, F10
12endocarditis30.4F10
13purpura30.4SERPINC1
14connective tissue disease30.3CD40LG, F3
15disseminated intravascular coagulation30.3F10, SERPINC1, F3
16thrombocytosis30.2GP1BA, F10, SERPINC1, F3
17pregnancy loss30.1F10, SERPINC1, F3, CD40LG
18cerebritis10.7
19hemoglobinuria10.5
20paroxysmal nocturnal hemoglobinuria10.5
21aneurysm10.5
22venous thromboembolism10.5
23polycythemia vera10.4
24hepatitis10.4
25myocarditis10.4
26obesity10.4
27polycythemia10.4
28giant cell myocarditis10.4
29endotheliitis10.4
30burns10.3
31transient global amnesia10.3
32essential thrombocythemia10.3
33acute adrenal insufficiency10.3
34mitral valve stenosis10.2
35marantic endocarditis10.2
36intracranial aneurysm10.2
37pituitary apoplexy10.2
38thrombotic thrombocytopenic purpura10.2
39splenic infarction10.2
40abdominal aortic aneurysm10.2
41double outlet right ventricle10.2
42ulcerative colitis10.2
43hepatic vein thrombosis10.2
44acquired thrombocytopenia10.2
45qualitative platelet defect10.2
46mixed connective tissue disease10.2
47wegener's granulomatosis10.2
48protein c deficiency10.2
49aortic aneurysm10.2
50cervicitis10.2

Graphical network of the top 20 diseases related to Heparin-Induced Thrombocytopenia:



Diseases related to heparin-induced thrombocytopenia

Symptoms for Heparin-Induced Thrombocytopenia

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Drugs & Therapeutics for Heparin-Induced Thrombocytopenia

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Heparin-Induced Thrombocytopenia

Drug clinical trials:

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Search NIH Clinical Center for Heparin-Induced Thrombocytopenia

Search CenterWatch for Heparin-Induced Thrombocytopenia

Genetic Tests for Heparin-Induced Thrombocytopenia

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Anatomical Context for Heparin-Induced Thrombocytopenia

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34MalaCards
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MalaCards organs/tissues related to Heparin-Induced Thrombocytopenia:

34
Testes, Skin, Liver, Heart, Monocytes, Endothelial, Pituitary, Whole blood, T cells, B cells, Lung, Colon

Animal Models for Heparin-Induced Thrombocytopenia or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Heparin-Induced Thrombocytopenia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.1CD40LG, F3, SERPINC1, F10
2MP:00053977.6CD40LG, F3, SERPINC1, FCGR2A, GP1BA
3MP:00053767.5GP1BA, F10, SERPINC1, F3, CD40LG
4MP:00107687.3F10, FCGR2A, SERPINC1, F3, CD40LG

Publications for Heparin-Induced Thrombocytopenia

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Sources:
53PubMed
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Articles related to Heparin-Induced Thrombocytopenia:

(show top 50)    (show all 663)
idTitleAuthorsYear
1
Heparin-induced thrombocytopenia associated with thrombotic microangiopathy. (23715106)
2013
2
Argatroban in heparin-induced thrombocytopenia: rationale for use and place in therapy. (24179672)
2013
3
The frequency of heparin-induced thrombocytopenia in Taiwanese patients undergoing cardiopulmonary bypass surgery. (24331583)
2013
4
Clinical and Laboratory Diagnosis of Heparin-Induced Thrombocytopenia: An Integrated Approach. (24363239)
2013
5
Heparin-induced thrombocytopenia: is it a graft-threatening complication? (23293891)
2013
6
Hemodialysis-associated acute systemic reactions and heparin-induced thrombocytopenia. (22127211)
2012
7
Treatment and prevention of heparin-induced thrombocytopenia: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. (22315270)
2012
8
Left ventricular assist device, heparin-induced thrombocytopenia, and thrombus formation. (22186463)
2012
9
Treatment outcomes of heparin-induced thrombocytopenia in subarachnoid hemorrhage patients: a 4-year, retrospective single-center review. (22692920)
2012
10
Pituitary metastasis presenting as ischemic pituitary apoplexy following heparin-induced thrombocytopenia. (23129546)
2012
11
Interleukin-10 promoter microsatellite polymorphisms influence the immune response to heparin and the risk of heparin-induced thrombocytopenia. (22239992)
2012
12
What are the options for anticoagulation needs in dialysis for patients with heparin-induced thrombocytopenia? (21851394)
2011
13
A clinical-laboratory algorithm incorporating optical density value to predict heparin-induced thrombocytopenia. (21264443)
2011
14
Heparin-induced thrombocytopenia and the utility of the 4Ts score in the Intensive Care Unit. (21255001)
2011
15
Evaluation of a standardized protocol using lepirudin or argatroban for heparin-induced thrombocytopenia. (21902659)
2011
16
Use of fondaparinux in a pregnant woman with pulmonary embolism and heparin-induced thrombocytopenia. (21525816)
2011
17
High rates of venous thromboembolism prophylaxis did not increase the incidence of heparin-induced thrombocytopenia. (21500716)
2011
18
HIT heparin-induced thrombocytopenia. (21572297)
2011
19
Novel use of plasmapheresis in a patient with heparin-induced thrombocytopenia requiring urgent insertion of a left ventricular assist device under cardiopulmonary bypass. (20723718)
2010
20
False-positive tests for heparin-induced thrombocytopenia in patients with antiphospholipid syndrome and systemic lupus erythematosus: a rebuttal. (20345710)
2010
21
Argatroban and renal replacement therapy in a morbidly obese patient with heparin-induced thrombocytopenia: a case report. (20116834)
2010
22
Heparin-induced thrombocytopenia in surgical patients. (20103065)
2010
23
Heparin-induced thrombocytopenia and warfarin-induced skin necrosis: case report. (21308322)
2010
24
Pulmonary embolectomy in heparin-induced thrombocytopenia and thrombosis? Safety of heparin use. (20962169)
2010
25
Treatment of heparin-induced thrombocytopenia after cardiac surgery: preliminary experience with fondaparinux. (19660283)
2010
26
Argatroban in the management of heparin-induced thrombocytopenia. (20859550)
2010
27
Heparin-induced thrombocytopenia type II with thrombosis in an intensive care patient: therapy management using the direct thrombin inhibitor argatroban]. (19795099)
2009
28
Dosing lepirudin in patients with heparin-induced thrombocytopenia and normal or impaired renal function: a single-center experience with 68 patients. (19059879)
2009
29
Clinical experience with argatroban for heparin-induced thrombocytopenia in a large teaching hospital. (22478907)
2009
30
Reducing harm associated with anticoagulation: practical considerations of argatroban therapy in heparin-induced thrombocytopenia. (19338378)
2009
31
A clinical-laboratory approach contributing to a rapid and reliable diagnosis of heparin-induced thrombocytopenia: An update. (19632705)
2009
32
Cerebral infarction associated with heparin-induced thrombocytopenia in a patient with encephalitis. (19122360)
2009
33
Delayed-onset heparin-induced thrombocytopenia type-2 during fondiparinux (Arixtra) therapy. (22128408)
2009
34
Hirudin for management of heparin-induced thrombocytopenia type II in a patient with biventricular assist device support. (20037107)
2009
35
Serologic results in >1000 patients with suspected heparin-induced thrombocytopenia. (17895512)
2008
36
Warfarin-induced skin necrosis in a patient with heparin-induced thrombocytopenia: two diseases or one? (19018128)
2008
37
Risk of heparin-induced thrombocytopenia in patients receiving thromboprophylaxis. (21083008)
2008
38
Heparin-induced thrombocytopenia: diagnosis and management. (18544310)
2008
39
Spontaneous superior sagittal sinus thrombosis secondary to type II heparin-induced thrombocytopenia presenting as an acute subarachnoid hemorrhage. (17582771)
2007
40
Anticoagulation options for patients with heparin-induced thrombocytopenia requiring renal support in the intensive care unit. (17464135)
2007
41
Heparin-induced thrombocytopenia in a uremic patient requiring hemodialysis: an alternative treatment and reexposure to heparin. (17456628)
2007
42
Incidence and clinical significance of anti-PF4/heparin antibodies of the IgG, IgM, and IgA class in 755 consecutive patient samples referred for diagnostic testing for heparin-induced thrombocytopenia. (16466367)
2006
43
Successful renal transplantation in a patient with heterozygous prothrombin gene, factor V Leiden mutation and heparin-induced thrombocytopenia using r-hirudin as anticoagulant. (16499600)
2006
44
Prevalence of heparin-induced thrombocytopenia in patients undergoing cardiac catheterization. (16875910)
2006
45
Use of ecarin clotting time in whole blood for monitoring recombinant hirudine treatment during cardiopulmonary bypass in patients with heparin-induced thrombocytopenia]. (15771978)
2005
46
Lepirudin for prophylaxis of thrombosis in patients with acute isolated heparin-induced thrombocytopenia: an analysis of 3 prospective studies. (15280202)
2004
47
Argatroban for prevention and treatment of thromboembolism in heparin-induced thrombocytopenia. (11302409)
2001
48
Factor V Leiden and thrombotic complications in heparin-induced thrombocytopenia. (9459322)
1998
49
Characterization of the humoral immune response in heparin-induced thrombocytopenia. (9067497)
1997
50
Heparin-induced thrombocytopenia and thrombosis. (9372019)
1995

Variations for Heparin-Induced Thrombocytopenia

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Expression for genes affiliated with Heparin-Induced Thrombocytopenia

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Heparin-Induced Thrombocytopenia

Search GEO for disease gene expression data for Heparin-Induced Thrombocytopenia.

Pathways for genes affiliated with Heparin-Induced Thrombocytopenia

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Sources:
51PathCards, 56Reactome, 54QIAGEN, 31KEGG, 39NCBI BioSystems Database, 55R&D Systems
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Pathways related to Heparin-Induced Thrombocytopenia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
8.9F3, SERPINC1, F10
2
Show member pathways
Complement Activation, Classical Pathway39
Complement and Coagulation Cascades39
8.9F10, SERPINC1, F3
3
Show member pathways
8.4F3, SERPINC1, F10, GP1BA
4
Show member pathways
8.4GP1BA, F10, SERPINC1, F3

Compounds for genes affiliated with Heparin-Induced Thrombocytopenia

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Sources:
46Novoseek, 52PharmGKB, 12DrugBank, 62Tocris Bioscience, 30IUPHAR, 3BitterDB, 25HMDB
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Compounds related to Heparin-Induced Thrombocytopenia according to GeneCards/GeneDecks:

(show top 50)    (show all 90)
idCompoundScoreTop Affiliating Genes
1celite469.7SERPINC1, F3
2roxifiban469.7F10, F3
3heparin pentasaccharide469.6F10, SERPINC1
4certoparin469.5SERPINC1, F3
5reviparin469.4SERPINC1, F3
6dabigatran52 4610.4F10, SERPINC1, F3
7efegatran469.4F10, SERPINC1, F3
8ecarin469.3F3, SERPINC1, F10
9inogatran469.3SERPINC1, F3
10nadroparin46 1210.3F10, SERPINC1, F3
11spectrozyme469.3F10, SERPINC1, F3
12danaparoid469.3F3, SERPINC1, F10
13rivaroxaban46 1210.3F10, SERPINC1, F3
14tinzaparin46 1210.3F10, SERPINC1, F3
15ximelagatran46 1210.3F10, F3, SERPINC1
16organon469.3F3, SERPINC1, F10
17heparinoids469.3F3, SERPINC1, F10
18fondaparinux469.3F10, SERPINC1, F3
19bivalirudin46 1210.3F10, SERPINC1, F3
20argatroban46 1210.3F3, SERPINC1, F10
21protamine sulfate469.3F10, SERPINC1, F3
22ristocetin469.3F3, SERPINC1, GP1BA
23desirudin469.2F10, F3
24desmopressin46 62 30 1212.2GP1BA, SERPINC1, F3
25coumarin46 3 52 2512.2F10, SERPINC1, F3
26protamine469.1F3, SERPINC1, F10
27dermatan sulfate469.1F10, SERPINC1, F3
28warfarin46 52 25 1212.1F3, SERPINC1, F10
29kininogen469.1GP1BA, SERPINC1, F3
30cardiolipin46 1210.0CD40LG, F3, F10
31silicone468.8CD40LG, SERPINC1, F10
32prostacyclin468.8GP1BA, FCGR2A, SERPINC1, F3
33aprotinin46 129.8F3, SERPINC1, F10, GP1BA
34ppack468.5F10, SERPINC1, F3, CD40LG
35epinephrine46 25 1210.5GP1BA, FCGR2A, F3, CD40LG
36tirofiban46 129.5CD40LG, F3, SERPINC1, F10
37clopidogrel46 52 25 1211.5F10, SERPINC1, F3, CD40LG
38fluorescein46 129.5F10, SERPINC1, F3, CD40LG
39dextran sulfate468.5F10, SERPINC1, F3, CD40LG
40phosphatidylserine46 30 1210.5GP1BA, F10, F3, CD40LG
41polyethylene glycol468.5CD40LG, SERPINC1, F10
42polysaccharide468.1F10, FCGR2A, SERPINC1, F3, CD40LG
43hirudin468.0GP1BA, F10, SERPINC1, F3, CD40LG
44aspirin46 52 30 2511.0GP1BA, F10, SERPINC1, F3, CD40LG
45fibrinogen468.0GP1BA, F10, SERPINC1, F3, CD40LG
46alanine467.9GP1BA, F10, SERPINC1, F3, CD40LG
47abciximab46 128.6CD40LG, F3, SERPINC1, FCGR2A, F10, GP1BA
48heparin46 30 25 1210.6GP1BA, F10, FCGR2A, SERPINC1, F3, CD40LG
49adp46 30 259.5GP1BA, F10, FCGR2A, SERPINC1, F3, CD40LG
50serine467.5GP1BA, F10, FCGR2A, SERPINC1, F3, CD40LG

GO Terms for genes affiliated with Heparin-Induced Thrombocytopenia

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17Gene Ontology
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Cellular components related to Heparin-Induced Thrombocytopenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intrinsic component of external side of plasma membraneGO:0312339.2F3, F10
2plasma membraneGO:0058867.1CD40LG, F3, SERPINC1, FCGR2A, F10, GP1BA

Biological processes related to Heparin-Induced Thrombocytopenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood coagulation, extrinsic pathwayGO:0075989.5F3, F10
2positive regulation of cell migrationGO:0303359.5F3, F10
3blood coagulation, intrinsic pathwayGO:0075979.3GP1BA, F10
4positive regulation of protein kinase B signalingGO:0518979.2F3, F10
5blood coagulationGO:0075968.5F3, SERPINC1, F10, GP1BA

Molecular functions related to Heparin-Induced Thrombocytopenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phospholipid bindingGO:0055439.5F3, F10
2protease bindingGO:0020209.1F3, SERPINC1

Products for genes affiliated with Heparin-Induced Thrombocytopenia

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Sources for Heparin-Induced Thrombocytopenia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet