HAT
MCID: HPR003
MIFTS: 55

Heparin-Induced Thrombocytopenia (HAT) malady

Blood category

Summaries for Heparin-Induced Thrombocytopenia

Sources:
43NIH Rare Diseases, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Heparin-induced thrombocytopenia (hit) is an adverse reaction to the drug heparin resulting in an abnormally low amount of platelets (thrombocytopenia). hit is usually an immune response which typically occurs 4-10 days after exposure to heparin; it can lead to serious complications and be life-threatening. this condition occurs in up to 5% of those who are exposed to heparin. characteristic signs of hit are a drop in platelet count of  greater than 50% and/or the formation of new blood clots during heparin therapy.  the first step of treatment is to discontinue and avoid all heparin products immediately. often, affected individuals require another medicine to prevent blood clotting (anticoagulants). last updated: 5/3/2012

MalaCards: Heparin-Induced Thrombocytopenia, also known as hit, is related to thrombocytopenia and venous thrombosis. An important gene associated with Heparin-Induced Thrombocytopenia is F3 (coagulation factor III (thromboplastin, tissue factor)), and among its related pathways are GP1b-IX-V activation signalling and Platelet Adhesion to exposed collagen. The compounds cardiolipin and dextran sulfate have been mentioned in the context of this disorder. Affiliated tissues include whole blood, heart and colon, and related mouse phenotypes are cardiovascular system and immune system.

Wikipedia:64 Heparin-induced thrombocytopenia (HIT) is the development of thrombocytopenia (a low platelet count),... more...

Aliases & Classifications for Heparin-Induced Thrombocytopenia

Sources:
43NIH Rare Diseases, 49Orphanet, 61UMLS, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Blood


Characteristics (Orphanet epidemiological data):

49
heparin-induced thrombocytopenia:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

heparin-induced thrombocytopenia 43 49 61
hit 43 49
heparin-induced thrombocytopenia type 2 49
heparin-associated thrombocytopenia 49
hat 49


External Ids:

ICD10 via Orphanet26 D69.5
SNOMED-CT via Orphanet58 73397007
UMLS via Orphanet62 C0272285

Related Diseases for Heparin-Induced Thrombocytopenia

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Heparin-Induced Thrombocytopenia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 337)
idRelated DiseaseScoreTop Affiliating Genes
1thrombocytopenia32.3CD40LG, CD79A, PF4, F3, GP1BA, GP5
2venous thrombosis30.9TNXA, F5, F10, PF4, F3, F2
3antiphospholipid syndrome30.8F10, CD40LG, CD79A, PF4, F3, F2
4thromboembolism30.8SERPINC1, TNXA, F5, F10, PF4, F3
5acute myocardial infarction30.7SERPINC1, PPBP, ITGA2B, F10, PF4, F3
6coronary thrombosis30.6F3, SERPINC1
7polycythemia vera30.6PF4, THBD, SELP
8systemic lupus erythematosus30.6F10, CD40LG, CD79A, F3, F2, FCGR2A
9sagittal sinus thrombosis30.5F5, SERPINC1
10stroke, ischemic30.5F2, F5
11myeloproliferative disorder30.4SELP, THBD, PF4, PPBP
12carotid artery thrombosis30.2F3
13hepatic vein thrombosis30.2F5, SERPINC1
14mitral valve stenosis30.2PPBP, PF4, SELP
15meningococcemia30.2F5, THBD, SERPINC1
16protein c deficiency30.2F5, F2, THBD, SERPINC1
17protein s deficiency30.2F5, F3, F2, SERPINC1
18pregnancy loss30.2F5, F10, CD40LG, F3, F2, SERPINC1
19thrombocytosis30.2PPBP, F10, PF4, F3, GP1BA, F2
20adult respiratory distress syndrome30.2F5, THBD, SELP
21arthritis30.1FCGR3A, FCGR2A, F10
22atherosclerosis30.1PPBP, ITGA2B, CD40LG, PF4, SERPINC1, SELP
23colorectal cancer29.9SELP, PF4
24sepsis29.9AZU1, F5, F10, F3, GP1BA, F2
25asthma29.9CD79A, F10, PPBP
26hemolytic-uremic syndrome29.7THBD
27hepatitis a29.7F2
28adenocarcinoma29.7THBD, PF4, TNXA
29primary biliary cirrhosis29.7CD40LG, CD79A, F2
30vasculitis29.7PPBP, CD40LG, CD79A, F2, THBD, SELP
31coronary artery disease,29.7PPBP, ITGA2B, F10, PF4, F3, GP1BA
32hemoglobinuria10.5
33paroxysmal nocturnal hemoglobinuria10.5
34venous thromboembolism10.5
35giant cell myocarditis10.4
36thrombocytopenia 410.4
37trypanosomiasis10.4
38transient global amnesia10.3
39acquired thrombocytopenia10.3
40n syndrome10.3
41essential thrombocythemia10.3
42thrombocytopenia 210.3
43acute adrenal insufficiency10.3
44lymphoma, diffuse large cell10.3
45hypertonia10.2
46diffuse large b-cell lymphoma10.2
47acute liver failure10.2
48marantic endocarditis10.2
49qualitative platelet defect10.2
50mixed connective tissue disease10.2

Graphical network of the top 20 diseases related to Heparin-Induced Thrombocytopenia:



Diseases related to heparin-induced thrombocytopenia

Clinical Features for Heparin-Induced Thrombocytopenia

Drugs & Therapeutics for Heparin-Induced Thrombocytopenia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Heparin-Induced Thrombocytopenia

Drug clinical trials:

Search ClinicalTrials for Heparin-Induced Thrombocytopenia

Search NIH Clinical Center for Heparin-Induced Thrombocytopenia

Search CenterWatch for Heparin-Induced Thrombocytopenia

Genetic Tests for Heparin-Induced Thrombocytopenia

Anatomical Context for Heparin-Induced Thrombocytopenia

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Heparin-Induced Thrombocytopenia:

33
Whole blood, Heart, Colon, Liver, Lung, Skin, Monocytes, T cells, B cells, Endothelial, Pituitary

Animal Models for Heparin-Induced Thrombocytopenia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Heparin-Induced Thrombocytopenia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053859.5F2, F3, CD40LG, F10, ITGA2B, SELP
2MP:00053878.6FCGR3A, THBD, SELP, SERPINC1, FCGR2A, F2
3MP:00053978.6GP1BA, F3, PF4, CD79A, ITGA2B, F2
4MP:00053768.1ITGA2B, SERPINC1, SELP, THBD, FCGR3A, F2

Publications for Heparin-Induced Thrombocytopenia

Sources:
51PubMed
See all sources

Articles related to Heparin-Induced Thrombocytopenia:

(show top 50)    (show all 673)
idTitleAuthorsYear
1
Nonheparin anticoagulants for heparin-induced thrombocytopenia. (23758251)
2013
2
Efficacy and safety of off-label use of fondaparinux in the management of heparin-induced thrombocytopenia with thrombosis in an elderly woman. (23832870)
2013
3
Unfractionated heparin versus low-molecular-weight heparin for avoiding heparin-induced thrombocytopenia in postoperative patients. (23942101)
2013
4
PF4/heparin antibody testing and treatment of heparin-induced thrombocytopenia in the intensive care unit. (22387583)
2013
5
Heparin-induced thrombocytopenia following hip and knee arthroplasty. (23406088)
2013
6
Impact of an Immunoglobulin G-Specific Enzyme-Linked Immunosorbent Assay on the Management of Heparin-Induced Thrombocytopenia. (23813781)
2013
7
Transient pseudothrombocytopenia associated with immune heparin-induced thrombocytopenia complicated by pulmonary embolism. (23636478)
2013
8
Treatment outcomes of heparin-induced thrombocytopenia in subarachnoid hemorrhage patients: a 4-year, retrospective single-center review. (22692920)
2012
9
Clinical and biologic features of patients suspected or confirmed to have heparin-induced thrombocytopenia in a cardiothoracic surgical ICU. (22406956)
2012
10
Management of heparin-induced thrombocytopenia. (22475438)
2012
11
Recognition of heparin-induced thrombocytopenia and initiation of argatroban therapy after cardiothoracic surgery in the intensive care unit. (22329977)
2012
12
A rare and undesirable complication of heparin-induced thrombocytopenia: acute massive pulmonary embolism. (20699250)
2011
13
Heparin-induced thrombocytopenia screening and management in pediatric patients. (22160029)
2011
14
Heparin-induced thrombocytopenia. (22236986)
2011
15
Heparin-induced thrombocytopenia type II because of heparin-coated polytetrafluoroethylene graft used to bypass. (21620669)
2011
16
Heparin-induced thrombocytopenia in the ICU: an overview. (21457505)
2011
17
A rare case of arterial thrombosis due to heparin-induced thrombocytopenia. (22340251)
2011
18
Treatment of heparin-induced thrombocytopenia after cardiac surgery: preliminary experience with fondaparinux. (19660283)
2010
19
Fondaparinux for the treatment of acute heparin-induced thrombocytopenia: a single-center experience. (19825921)
2010
20
Cardiac transplantation and/or mechanical circulatory support device placement using heparin anti-coagulation in the presence of acute heparin-induced thrombocytopenia. (19819167)
2010
21
Cerebral sinus thrombosis and heparin-induced thrombocytopenia in a patient with paroxysmal nocturnal hemoglobinuria. (20467181)
2010
22
Treatment options in heparin-induced thrombocytopenia. (20601872)
2010
23
Heparin-induced thrombocytopenia type II with thrombosis in an intensive care patient: therapy management using the direct thrombin inhibitor argatroban]. (19795099)
2009
24
A clinical-laboratory approach contributing to a rapid and reliable diagnosis of heparin-induced thrombocytopenia: An update. (19632705)
2009
25
Development of a real-time PCR detection method for a FCGR2A polymorphism in the LightCycler and application in the heparin-induced thrombocytopenia syndrome. (19664613)
2009
26
Heparin-induced multiple electrode aggregometry: a potential tool for improvement of heparin-induced thrombocytopenia diagnosis. (20015320)
2009
27
Studies of the immune response in heparin-induced thrombocytopenia. (19144981)
2009
28
Splenic infarction and subsequent splenic rupture in a patient with paroxysmal nocturnal hemoglobinuria and heparin-induced thrombocytopenia. (19415735)
2009
29
Argatroban use in heparin-induced thrombocytopenia. (18627333)
2008
30
HIT happens: diagnosing and evaluating the patient with heparin-induced thrombocytopenia. (18633006)
2008
31
Urgent cardiac surgery in a patient with a remote history of heparin-induced thrombocytopenia: use of the anti-PF4/heparin ELISA confirmatory test. (18633011)
2008
32
Usefulness of pretest clinical score (4Ts) combined with immunoassay for the diagnosis of heparin-induced thrombocytopenia. (18664968)
2008
33
Images in cardiovascular medicine. Acute reversible bioprosthetic mitral valve stenosis caused by heparin-induced thrombocytopenia. (18645060)
2008
34
Platelet PlA2 Polymorphism and the risk for thrombosis in heparin-induced thrombocytopenia. (18208809)
2008
35
Heparin induced thrombocytopenia: pathogenetic, clinical, diagnostic and therapeutic aspects. (17896955)
2007
36
Incidence and clinical significance of anti-PF4/heparin antibodies of the IgG, IgM, and IgA class in 755 consecutive patient samples referred for diagnostic testing for heparin-induced thrombocytopenia. (16466367)
2006
37
Argatroban dosing of patients with heparin-induced thrombocytopenia and an elevated aPTT due to antiphospholipid antibody syndrome. (16569813)
2006
38
Use of bivalirudin to treat heparin-induced thrombocytopenia in a patient with idiopathic giant-cell myocarditis. (16768056)
2006
39
Fondaparinux for thromboembolic treatment and prophylaxis of heparin-induced thrombocytopenia. (16788093)
2006
40
Newer insights on the mechanism of heparin-induced thrombocytopenia. (15085467)
2004
41
Argatroban for heparin-induced thrombocytopenia in hepato-renal failure and CVVHD. (12921505)
2003
42
Risk factors and long-term follow-up of patients with the immune type of heparin-induced thrombocytopenia. (12516684)
2002
43
Segmental hepatic vein thrombosis associated with heparin-induced thrombocytopenia II. (10664167)
2000
44
Heparin-induced thrombocytopenia: diagnostic tests and biological mechanisms. (10097819)
1998
45
Pentosan induced cerebral sagittal sinus thrombosis: a variant of heparin induced thrombocytopenia. (9817346)
1998
46
Characterization of the humoral immune response in heparin-induced thrombocytopenia. (9067497)
1997
47
Danaparoid. A review of its pharmacology and clinical use in the management of heparin-induced thrombocytopenia. (9421696)
1997
48
Platelet binding of IgG from patients with heparin-induced thrombocytopenia. (8621980)
1996
49
Pathogenicity of IgA and/or IgM antibodies to heparin-PF4 complexes in patients with heparin-induced thrombocytopenia. (8616093)
1996
50
Comparison of PF4/heparin ELISA assay with the 14C-serotonin release assay in the diagnosis of heparin-induced thrombocytopenia. (8526207)
1995

Genetic Variations for Heparin-Induced Thrombocytopenia

Expression for genes affiliated with Heparin-Induced Thrombocytopenia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Heparin-Induced Thrombocytopenia

Search GEO for disease gene expression data for Heparin-Induced Thrombocytopenia.

Pathways for genes affiliated with Heparin-Induced Thrombocytopenia

Sources:
54Reactome, 50PharmGKB, 30KEGG, 38NCBI BioSystems Database, 52QIAGEN, 53R&D Systems
See all sources

Pathways related to Heparin-Induced Thrombocytopenia according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1GP1BA, GP5
210.1GP5, GP1BA
3
Hide members
10.0FCGR2A, FCGR3A, CD40LG
4
Hide members
10.0F2, F3, F10
510.0FCGR2A, FCGR3A, SELP
610.0SELP, THBD, F2
79.9ITGA2B, GP1BA, GP5
89.9ITGA2B, GP5, F2
9
Hide members
9.7F2, ITGA2B, GP1BA, GP5
10
Hide members
9.6F5, F3, F2, THBD, SERPINC1, F10
11
Hide members
9.6SERPINC1, F10, THBD, F2, F3, F5
12
Hide members
9.6PPBP, PF4, F10, F5, ITGA2B
13
Hide members
9.5PF4, PPBP, ITGA2B, F5, SELP
14
Hide members
9.4F3, F5, F10, F2, THBD, SERPINC1
15
Hide members
9.3SERPINC1, GP1BA, SELP, THBD, F2, GP5
16
Hide members
9.2GP1BA, THBD, GP5, SERPINC1, F3, F10

Compounds for genes affiliated with Heparin-Induced Thrombocytopenia

Sources:
45Novoseek, 11DrugBank, 50PharmGKB, 24HMDB, 29IUPHAR, 60Tocris Bioscience
See all sources

Compounds related to Heparin-Induced Thrombocytopenia according to GeneCards/GeneDecks:

(show top 50)    (show all 201)
idCompoundScoreTop Affiliating Genes
1cardiolipin45 1111.7F10
2dextran sulfate4510.2F5, F10, CD40LG, SELP
3kininogen4510.1F3, SERPINC1, F2, F5, GP1BA
4ecarin4510.1F10, F3, F2, F5, SERPINC1
5spectrozyme4510.0F5, F10, F3, SERPINC1, F2
6ximelagatran45 1111.0F5, F10, F3, F2, THBD, SERPINC1
7nadroparin45 1111.0F10, SERPINC1, F3, SELP, TNXA
8heparinoids4510.0F5, F10, F3, F2, THBD, SERPINC1
9warfarin45 50 11 2413.0PPBP, CD79A, PF4, SELP, SERPINC1
10adp45 29 2412.0ITGA2B, CD40LG, PPBP, PF4
11ppack459.9F10, CD40LG, F3, F2, SERPINC1, SELP
12inogatran459.9F2, SERPINC1, F3, F5
13ancrod459.9F5, THBD, SERPINC1, F2, F10
14tinzaparin45 1110.9F10, F3, AZU1, TNXA, SERPINC1
15phosphatidylserine45 29 1111.8TNXA, F2, GP1BA, F3, CD79A, F10
16protamine sulfate459.7AZU1, F5, F10, PF4, F3, F2
17ristocetin459.7PPBP, F5, F3, GP1BA, F2, SELP
18danaparoid459.7SERPINC1, F2, F3, TNXA, F5, F10
1911-dehydrothromboxane b2459.7THBD, PPBP, F2, PF4, SELP
20gamma-carboxyglutamic acid459.7TNXA, F5, F10, PF4, F3, F2
21serine459.6GP1BA, FCGR2A, AZU1, ITGA2B, F10
22tirofiban45 1110.6ITGA2B, F10, CD40LG, PF4, F2, SELP
23iloprost45 60 29 1112.6THBD, SERPINC1, PPBP, PF4, F3, SELP
24bivalirudin45 1110.6TNXA, F5, F10, F3, F2, THBD
25ticlopidine45 1110.6F3, PPBP, SERPINC1, SELP, PF4
26argatroban45 1110.6THBD, SELP, SERPINC1, F2, F3, F10
27desmopressin45 60 29 1112.6PPBP, F5, F3, GP1BA, F2, THBD
28protamine459.6TNXA, F5, F10, PF4, F3, F2
29fondaparinux459.6TNXA, F5, F10, PF4, F3, F2
30clopidogrel50 45 11 2412.5SERPINC1, TNXA, PPBP, F10, CD40LG, F3
31hirugen459.5F5, F2, THBD, SERPINC1
32polyethylene glycol459.5THBD, F5, F10, CD40LG, CD79A, PF4
33dipyridamole45 60 29 1112.5SELP, F2, F3, CD79A, PF4, PPBP
34penicillin459.4SELP, PPBP, F2, CD79A, F5
35aprotinin45 1110.4SERPINC1, SELP, AZU1, PPBP, F5, F10
36prostacyclin459.3THBD, SELP, SERPINC1, PPBP, FCGR2A, GP1BA
37dermatan sulfate459.2TNXA, F5, F10, PF4, F3, F2
38citrate459.2F10, CD79A, PF4, F3, THBD, PPBP
39abciximab45 1110.1ITGA2B, F10, CD40LG, PF4, F3, GP1BA
40epinephrine45 11 2411.1FCGR2A, F2, GP1BA, F3, PF4, CD79A
41hirudin459.1F3, GP1BA, F2, THBD, SELP, SERPINC1
42heparin45 29 11 2412.0CD40LG, GP1BA, F10, PPBP, AZU1, CD79A
43polysaccharide458.9F3, CD40LG, FCGR2A, THBD, SELP, SERPINC1
44creatinine458.8CD79A, PF4, F3, F2, SERPINC1, THBD
45lactate458.8PF4, GP1BA, GP5, F2, THBD, SELP
46vegf458.7F10, AZU1, PPBP, CD40LG, SERPINC1, SELP
47arginine458.7SERPINC1, THBD, FCGR3A, SELP, AZU1, TNXA
48alanine458.6SERPINC1, F3, TNXA, THBD, F2, PPBP
49aspirin45 50 29 2411.4PF4, CD79A, CD40LG, F10, F5, PPBP
50fibrinogen458.2TNXA, PPBP, ITGA2B, F5, F10, CD40LG

GO Terms for genes affiliated with Heparin-Induced Thrombocytopenia

Sources:
16Gene Ontology
See all sources

Cellular components related to Heparin-Induced Thrombocytopenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule membraneGO:03109210.1SELP, ITGA2B
2intrinsic to external side of plasma membraneGO:03123310.1F3, F10
3external side of plasma membraneGO:0098979.7FCGR3A, CD79A, CD40LG, ITGA2B, SELP
4platelet alpha granule lumenGO:0310939.6PPBP, F5, PF4
5extracellular spaceGO:0056159.2PPBP, F5, F2, SERPINC1, SELP, F3
6extracellular regionGO:0055769.0F5, FCGR3A, F2, PF4, F10, PPBP
7plasma membraneGO:0058868.3CD40LG, SERPINC1, SELP, THBD, F5, FCGR3A

Biological processes related to Heparin-Induced Thrombocytopenia according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1blood coagulation, extrinsic pathwayGO:00759810.3F10, F3
2B cell proliferationGO:04210010.1CD79A, CD40LG
3regulation of blood coagulationGO:03019310.1GP1BA, F2
4negative regulation of platelet activationGO:01054410.0GP5, F2, THBD
5negative regulation of fibrinolysisGO:05191810.0THBD, F2
6blood coagulation, intrinsic pathwayGO:0075979.9F10, GP1BA, GP5, F2
7peptidyl-glutamic acid carboxylationGO:0171879.8F2, F10
8platelet degranulationGO:0025769.7SELP, PPBP, ITGA2B, F5, PF4
9cell adhesionGO:0071559.6SELP, GP1BA, F5, ITGA2B, GP5
10platelet activationGO:0301689.0ITGA2B, F5, CD40LG, PF4, GP1BA, PPBP
11blood coagulationGO:0075968.6THBD, F2, GP5, GP1BA, F3, PF4

Molecular functions related to Heparin-Induced Thrombocytopenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1IgG bindingGO:01986410.2FCGR3A, FCGR2A
2heparin bindingGO:0082019.5SERPINC1, SELP, PF4, AZU1

Products for genes affiliated with Heparin-Induced Thrombocytopenia

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Heparin-Induced Thrombocytopenia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet