HAT
MCID: HPR003
MIFTS: 53

Heparin-Induced Thrombocytopenia (HAT) malady

Rare diseases, Blood diseases categories
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Summaries for Heparin-Induced Thrombocytopenia

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NIH Rare Diseases:42 Heparin-induced thrombocytopenia (hit) is an adverse reaction to the drug heparin resulting in an abnormally low amount of platelets (thrombocytopenia). hit is usually an immune response which typically occurs 4-10 days after exposure to heparin; it can lead to serious complications and be life-threatening. this condition occurs in up to 5% of those who are exposed to heparin. characteristic signs of hit are a drop in platelet count of  greater than 50% and/or the formation of new blood clots during heparin therapy.  the first step of treatment is to discontinue and avoid all heparin products immediately. often, affected individuals require another medicine to prevent blood clotting (anticoagulants). last updated: 5/3/2012

MalaCards based summary: Heparin-Induced Thrombocytopenia, also known as hit, is related to thrombocytopenia and sagittal sinus thrombosis. An important gene associated with Heparin-Induced Thrombocytopenia is F3 (coagulation factor III (thromboplastin, tissue factor)), and among its related pathways are Collagen biosynthesis and modifying enzymes and Complement and coagulation cascades. The compounds celite and roxifiban have been mentioned in the context of this disorder. Affiliated tissues include testes, heart and liver, and related mouse phenotypes are cardiovascular system and hematopoietic system.

Wikipedia:65 Heparin-induced thrombocytopenia (HIT) is the development of thrombocytopenia (a low platelet count),... more...

Aliases & Classifications for Heparin-Induced Thrombocytopenia

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Sources:
42NIH Rare Diseases, 48Orphanet, 62UMLS, 26ICD10 via Orphanet, 63UMLS via Orphanet
See all sources

Heparin-Induced Thrombocytopenia, Aliases & Descriptions:

Name: Heparin-Induced Thrombocytopenia 42 48 62
Hit 42 48 62
Heparin-Induced Thrombocytopenia Type 2 48
 
Heparin-Associated Thrombocytopenia 48
Hat 48


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Blood diseases


Characteristics (Orphanet epidemiological data):

48
heparin-induced thrombocytopenia:
Inheritance: Sporadic; Age of onset: Variable


External Ids:

ICD10 via Orphanet26 D69.5
UMLS via Orphanet63 C0272285

Related Diseases for Heparin-Induced Thrombocytopenia

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Diseases related to Heparin-Induced Thrombocytopenia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 107)
idRelated DiseaseScoreTop Affiliating Genes
1thrombocytopenia31.2SERPINC1, CD40LG, F3, GP1BA, F10, FCGR2A
2sagittal sinus thrombosis31.1SERPINC1
3pulmonary embolism31.1F3, SERPINC1, F10
4thromboembolism31.0SERPINC1, F3, F10
5coronary thrombosis31.0SERPINC1, F3
6endocarditis30.9F10
7purpura30.8SERPINC1
8venous thrombosis30.6FCGR2A, F10, SERPINC1, F3
9acute myocardial infarction30.6SERPINC1, F3, F10
10antiphospholipid syndrome30.5CD40LG, F3, SERPINC1, F10
11lupus erythematosus30.4CD40LG, F3, SERPINC1
12myocardial infarction30.4SERPINC1, F3, F10, GP1BA
13connective tissue disease30.3CD40LG, F3
14disseminated intravascular coagulation30.3SERPINC1, F3, F10
15systemic lupus erythematosus30.2FCGR2A, CD40LG, F3, F10
16thrombocytosis29.9F10, SERPINC1, F3, GP1BA
17pregnancy loss29.8CD40LG, F3, SERPINC1, F10
18sepsis29.6GP1BA, F10, FCGR2A, SERPINC1, F3
19cerebritis10.7
20paroxysmal nocturnal hemoglobinuria10.5
21hemoglobinuria10.5
22aneurysm10.5
23venous thromboembolism10.5
24carotid artery thrombosis10.5F3
25hepatitis10.4
26obesity10.4
27polycythemia vera10.4
28myocarditis10.4
29polycythemia10.4
30catastrophic antiphospholipid syndrome10.4
31giant cell myocarditis10.4
32endotheliitis10.4
33dysfibrinogenemia10.4SERPINC1
34viral hepatitis10.4F10
35burns10.3
36transient global amnesia10.3
37essential thrombocythemia10.3
38acute adrenal insufficiency10.3
39hemorrhagic fever10.3CD40LG
40scrub typhus10.3CD40LG
41factor x deficiency10.2F10, F3
42hemarthrosis10.2F3, F10
43von willebrand's disease10.2GP1BA, F3
44afibrinogenemia10.2F3, F10
45hemophilia b10.2F10, F3
46intracranial thrombosis10.2F3, SERPINC1
47liver disease10.2
48ulcerative colitis10.2
49splenic infarction10.2
50abdominal aortic aneurysm10.2

Graphical network of the top 20 diseases related to Heparin-Induced Thrombocytopenia:



Diseases related to heparin-induced thrombocytopenia

Symptoms for Heparin-Induced Thrombocytopenia

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Drugs & Therapeutics for Heparin-Induced Thrombocytopenia

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Drug clinical trials:

Search ClinicalTrials for Heparin-Induced Thrombocytopenia

Search NIH Clinical Center for Heparin-Induced Thrombocytopenia

Genetic Tests for Heparin-Induced Thrombocytopenia

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Anatomical Context for Heparin-Induced Thrombocytopenia

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MalaCards organs/tissues related to Heparin-Induced Thrombocytopenia:

32
Testes, Heart, Liver, Skin, Monocytes, Endothelial, Whole blood, Pituitary, Colon, Lung, T cells, B cells

Animal Models for Heparin-Induced Thrombocytopenia or affiliated genes

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MGI Mouse Phenotypes related to Heparin-Induced Thrombocytopenia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.1CD40LG, F3, SERPINC1, F10
2MP:00053977.6CD40LG, F3, SERPINC1, FCGR2A, GP1BA
3MP:00053767.5GP1BA, F10, SERPINC1, F3, CD40LG
4MP:00107687.3F10, FCGR2A, SERPINC1, F3, CD40LG

Publications for Heparin-Induced Thrombocytopenia

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Articles related to Heparin-Induced Thrombocytopenia:

(show top 50)    (show all 691)
idTitleAuthorsYear
1
Catastrophic antiphospholipid syndrome and heparin-induced thrombocytopenia presenting with adrenal insufficiency caused by bilateral hemorrhagic adrenal infarction during sepsis. (24709482)
2014
2
Heparin-induced thrombocytopenia associated with thrombotic microangiopathy. (23715106)
2013
3
Argatroban in heparin-induced thrombocytopenia: rationale for use and place in therapy. (24179672)
2013
4
The frequency of heparin-induced thrombocytopenia in Taiwanese patients undergoing cardiopulmonary bypass surgery. (24331583)
2013
5
Clinical and Laboratory Diagnosis of Heparin-Induced Thrombocytopenia: An Integrated Approach. (24363239)
2013
6
Heparin-induced thrombocytopenia: is it a graft-threatening complication? (23293891)
2013
7
Hemodialysis-associated acute systemic reactions and heparin-induced thrombocytopenia. (22127211)
2012
8
Treatment and prevention of heparin-induced thrombocytopenia: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. (22315270)
2012
9
Left ventricular assist device, heparin-induced thrombocytopenia, and thrombus formation. (22186463)
2012
10
Treatment outcomes of heparin-induced thrombocytopenia in subarachnoid hemorrhage patients: a 4-year, retrospective single-center review. (22692920)
2012
11
Pituitary metastasis presenting as ischemic pituitary apoplexy following heparin-induced thrombocytopenia. (23129546)
2012
12
Interleukin-10 promoter microsatellite polymorphisms influence the immune response to heparin and the risk of heparin-induced thrombocytopenia. (22239992)
2012
13
What are the options for anticoagulation needs in dialysis for patients with heparin-induced thrombocytopenia? (21851394)
2011
14
A clinical-laboratory algorithm incorporating optical density value to predict heparin-induced thrombocytopenia. (21264443)
2011
15
Heparin-induced thrombocytopenia and the utility of the 4Ts score in the Intensive Care Unit. (21255001)
2011
16
Evaluation of a standardized protocol using lepirudin or argatroban for heparin-induced thrombocytopenia. (21902659)
2011
17
Use of fondaparinux in a pregnant woman with pulmonary embolism and heparin-induced thrombocytopenia. (21525816)
2011
18
High rates of venous thromboembolism prophylaxis did not increase the incidence of heparin-induced thrombocytopenia. (21500716)
2011
19
HIT heparin-induced thrombocytopenia. (21572297)
2011
20
Novel use of plasmapheresis in a patient with heparin-induced thrombocytopenia requiring urgent insertion of a left ventricular assist device under cardiopulmonary bypass. (20723718)
2010
21
False-positive tests for heparin-induced thrombocytopenia in patients with antiphospholipid syndrome and systemic lupus erythematosus: a rebuttal. (20345710)
2010
22
Argatroban and renal replacement therapy in a morbidly obese patient with heparin-induced thrombocytopenia: a case report. (20116834)
2010
23
Heparin-induced thrombocytopenia in surgical patients. (20103065)
2010
24
Heparin-induced thrombocytopenia and warfarin-induced skin necrosis: case report. (21308322)
2010
25
Pulmonary embolectomy in heparin-induced thrombocytopenia and thrombosis? Safety of heparin use. (20962169)
2010
26
Treatment of heparin-induced thrombocytopenia after cardiac surgery: preliminary experience with fondaparinux. (19660283)
2010
27
Argatroban in the management of heparin-induced thrombocytopenia. (20859550)
2010
28
Heparin-induced thrombocytopenia type II with thrombosis in an intensive care patient: therapy management using the direct thrombin inhibitor argatroban]. (19795099)
2009
29
Dosing lepirudin in patients with heparin-induced thrombocytopenia and normal or impaired renal function: a single-center experience with 68 patients. (19059879)
2009
30
Clinical experience with argatroban for heparin-induced thrombocytopenia in a large teaching hospital. (22478907)
2009
31
Reducing harm associated with anticoagulation: practical considerations of argatroban therapy in heparin-induced thrombocytopenia. (19338378)
2009
32
A clinical-laboratory approach contributing to a rapid and reliable diagnosis of heparin-induced thrombocytopenia: An update. (19632705)
2009
33
Cerebral infarction associated with heparin-induced thrombocytopenia in a patient with encephalitis. (19122360)
2009
34
Delayed-onset heparin-induced thrombocytopenia type-2 during fondiparinux (Arixtra) therapy. (22128408)
2009
35
Serologic results in >1000 patients with suspected heparin-induced thrombocytopenia. (17895512)
2008
36
Warfarin-induced skin necrosis in a patient with heparin-induced thrombocytopenia: two diseases or one? (19018128)
2008
37
Risk of heparin-induced thrombocytopenia in patients receiving thromboprophylaxis. (21083008)
2008
38
Heparin-induced thrombocytopenia: diagnosis and management. (18544310)
2008
39
Spontaneous superior sagittal sinus thrombosis secondary to type II heparin-induced thrombocytopenia presenting as an acute subarachnoid hemorrhage. (17582771)
2007
40
Anticoagulation options for patients with heparin-induced thrombocytopenia requiring renal support in the intensive care unit. (17464135)
2007
41
Heparin-induced thrombocytopenia in a uremic patient requiring hemodialysis: an alternative treatment and reexposure to heparin. (17456628)
2007
42
Incidence and clinical significance of anti-PF4/heparin antibodies of the IgG, IgM, and IgA class in 755 consecutive patient samples referred for diagnostic testing for heparin-induced thrombocytopenia. (16466367)
2006
43
Successful renal transplantation in a patient with heterozygous prothrombin gene, factor V Leiden mutation and heparin-induced thrombocytopenia using r-hirudin as anticoagulant. (16499600)
2006
44
Prevalence of heparin-induced thrombocytopenia in patients undergoing cardiac catheterization. (16875910)
2006
45
Use of ecarin clotting time in whole blood for monitoring recombinant hirudine treatment during cardiopulmonary bypass in patients with heparin-induced thrombocytopenia]. (15771978)
2005
46
Lepirudin for prophylaxis of thrombosis in patients with acute isolated heparin-induced thrombocytopenia: an analysis of 3 prospective studies. (15280202)
2004
47
Argatroban for prevention and treatment of thromboembolism in heparin-induced thrombocytopenia. (11302409)
2001
48
Factor V Leiden and thrombotic complications in heparin-induced thrombocytopenia. (9459322)
1998
49
Characterization of the humoral immune response in heparin-induced thrombocytopenia. (9067497)
1997
50
Heparin-induced thrombocytopenia and thrombosis. (9372019)
1995

Variations for Heparin-Induced Thrombocytopenia

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Expression for genes affiliated with Heparin-Induced Thrombocytopenia

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Expression patterns in normal tissues for genes affiliated with Heparin-Induced Thrombocytopenia

Search GEO for disease gene expression data for Heparin-Induced Thrombocytopenia.

Pathways for genes affiliated with Heparin-Induced Thrombocytopenia

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Pathways related to Heparin-Induced Thrombocytopenia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
8.9F3, SERPINC1, F10
2
Show member pathways
Complement Activation, Classical Pathway37
Complement and Coagulation Cascades37
8.9F3, SERPINC1, F10
3
Show member pathways
8.4F3, SERPINC1, F10, GP1BA
4
Show member pathways
8.4GP1BA, F10, SERPINC1, F3

Compounds for genes affiliated with Heparin-Induced Thrombocytopenia

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Compounds related to Heparin-Induced Thrombocytopenia according to GeneCards/GeneDecks:

(show top 50)    (show all 90)
idCompoundScoreTop Affiliating Genes
1celite449.7F3, SERPINC1
2roxifiban449.6F10, F3
3heparin pentasaccharide449.6F10, SERPINC1
4reviparin449.6F3, SERPINC1
5certoparin449.4SERPINC1, F3
6efegatran449.4SERPINC1, F10, F3
7dabigatran50 4410.4F3, SERPINC1, F10
8ecarin449.3F10, SERPINC1, F3
9inogatran449.3F3, SERPINC1
10spectrozyme449.3F3, SERPINC1, F10
11nadroparin44 1110.3SERPINC1, F3, F10
12danaparoid449.3F3, SERPINC1, F10
13tinzaparin44 1110.3F10, SERPINC1, F3
14rivaroxaban44 1110.3F10, SERPINC1, F3
15ximelagatran44 1110.3SERPINC1, F10, F3
16organon449.3F3, SERPINC1, F10
17heparinoids449.3F10, SERPINC1, F3
18fondaparinux449.3F3, SERPINC1, F10
19bivalirudin44 1110.3F10, SERPINC1, F3
20argatroban44 1110.3SERPINC1, F3, F10
21protamine sulfate449.3SERPINC1, F3, F10
22ristocetin449.3SERPINC1, GP1BA, F3
23desirudin449.2F3, F10
24coumarin44 2 50 2412.2SERPINC1, F10, F3
25desmopressin44 61 28 1112.2SERPINC1, F3, GP1BA
26protamine449.1SERPINC1, F3, F10
27dermatan sulfate449.1F3, SERPINC1, F10
28warfarin44 50 24 1112.1F10, SERPINC1, F3
29kininogen449.1GP1BA, SERPINC1, F3
30cardiolipin44 1110.0F10, F3, CD40LG
31silicone448.8F10, SERPINC1, CD40LG
32prostacyclin448.8F3, FCGR2A, SERPINC1, GP1BA
33aprotinin44 119.8F3, GP1BA, SERPINC1, F10
34ppack448.5CD40LG, F10, SERPINC1, F3
35epinephrine44 24 1110.5FCGR2A, CD40LG, F3, GP1BA
36tirofiban44 119.5SERPINC1, CD40LG, F10, F3
37fluorescein44 119.5CD40LG, SERPINC1, F3, F10
38clopidogrel44 50 24 1111.5SERPINC1, F3, F10, CD40LG
39dextran sulfate448.5F10, F3, CD40LG, SERPINC1
40phosphatidylserine44 28 1110.5F10, CD40LG, GP1BA, F3
41polyethylene glycol448.5CD40LG, SERPINC1, F10
42polysaccharide448.1SERPINC1, F10, F3, CD40LG, FCGR2A
43hirudin448.0F3, SERPINC1, F10, GP1BA, CD40LG
44aspirin44 50 28 2411.0F3, CD40LG, SERPINC1, GP1BA, F10
45fibrinogen448.0F3, CD40LG, SERPINC1, GP1BA, F10
46alanine447.9F10, SERPINC1, F3, GP1BA, CD40LG
47abciximab44 118.6F3, GP1BA, F10, FCGR2A, SERPINC1, CD40LG
48heparin44 28 24 1110.6GP1BA, CD40LG, FCGR2A, SERPINC1, F3, F10
49adp44 28 249.5F3, F10, SERPINC1, FCGR2A, GP1BA, CD40LG
50serine447.5FCGR2A, GP1BA, CD40LG, F10, F3, SERPINC1

GO Terms for genes affiliated with Heparin-Induced Thrombocytopenia

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Cellular components related to Heparin-Induced Thrombocytopenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intrinsic component of external side of plasma membraneGO:0312339.2F3, F10
2plasma membraneGO:0058867.1CD40LG, F3, SERPINC1, FCGR2A, F10, GP1BA

Biological processes related to Heparin-Induced Thrombocytopenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood coagulation, extrinsic pathwayGO:0075989.5F3, F10
2positive regulation of cell migrationGO:0303359.5F3, F10
3blood coagulation, intrinsic pathwayGO:0075979.3GP1BA, F10
4positive regulation of protein kinase B signalingGO:0518979.2F3, F10
5blood coagulationGO:0075968.5F3, SERPINC1, F10, GP1BA

Molecular functions related to Heparin-Induced Thrombocytopenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phospholipid bindingGO:0055439.5F3, F10
2protease bindingGO:0020209.1F3, SERPINC1

Products for genes affiliated with Heparin-Induced Thrombocytopenia

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Sources for Heparin-Induced Thrombocytopenia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet