MCID: HPR003
MIFTS: 48

Heparin-Induced Thrombocytopenia

Categories: Rare diseases, Blood diseases

Aliases & Classifications for Heparin-Induced Thrombocytopenia

MalaCards integrated aliases for Heparin-Induced Thrombocytopenia:

Name: Heparin-Induced Thrombocytopenia 49 55 69
Hit 49 55
Heparin-Induced Thrombocytopenia Type 2 55
Heparin-Associated Thrombocytopenia 55
Hat 55

Characteristics:

Orphanet epidemiological data:

55
heparin-induced thrombocytopenia
Inheritance: Not applicable; Age of onset: All ages;

Classifications:



External Ids:

Orphanet 55 ORPHA3325
UMLS via Orphanet 70 C0272285
ICD10 via Orphanet 33 D69.5
UMLS 69 C0272285

Summaries for Heparin-Induced Thrombocytopenia

NIH Rare Diseases : 49 Heparin-induced thrombocytopenia (HIT) is an adverse reaction to the drug heparin resulting in an abnormally low amount of platelets (thrombocytopenia). HIT is usually an immune response which typically occurs 4-10 days after exposure to heparin; it can lead to serious complications and be life-threatening. This condition occurs in up to 5% of those who are exposed to heparin. Characteristic signs of HIT are a drop in platelet count of  greater than 50% and/or the formation of new blood clots during heparin therapy.  The first step of treatment is to discontinue and avoid all heparin products immediately. Often, affected individuals require another medicine to prevent blood clotting (anticoagulants). Last updated: 5/3/2012

MalaCards based summary : Heparin-Induced Thrombocytopenia, also known as hit, is related to catastrophic antiphospholipid syndrome and budd-chiari syndrome. An important gene associated with Heparin-Induced Thrombocytopenia is F3 (Coagulation Factor III, Tissue Factor), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Heparin and Fondaparinux have been mentioned in the context of this disorder. Affiliated tissues include testes, liver and heart, and related phenotypes are cardiovascular system and hematopoietic system

Wikipedia : 72 Heparin-induced thrombocytopenia (HIT) is the development of thrombocytopenia (a low platelet count),... more...

Related Diseases for Heparin-Induced Thrombocytopenia

Diseases related to Heparin-Induced Thrombocytopenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 157)
# Related Disease Score Top Affiliating Genes
1 catastrophic antiphospholipid syndrome 30.5 CD40LG F3
2 budd-chiari syndrome 30.3 F3 SERPINC1
3 coronary thrombosis 30.2 F3 SERPINC1
4 sagittal sinus thrombosis 30.2 F3 SERPINC1
5 qualitative platelet defect 30.1 F3 SELP
6 thrombosis 30.0 F10 F3 SELP SERPINC1
7 thrombocytopenia due to platelet alloimmunization 30.0 CD40LG SELP
8 pulmonary embolism 29.9 F10 F3 SERPINC1
9 marantic endocarditis 29.9 F3 SERPINC1
10 thrombotic thrombocytopenic purpura 29.8 F3 SELP
11 protein s deficiency 29.8 F3 SERPINC1
12 mitral valve stenosis 29.8 SELP SERPINC1
13 acute myocardial infarction 29.7 F3 SELP SERPINC1
14 thrombophilia due to thrombin defect 29.7 F10 F3 SERPINC1
15 endocarditis 29.7 FCGR2A SERPINC1
16 disseminated intravascular coagulation 29.6 F3 SERPINC1
17 purpura 29.5 CD40LG F3 SERPINC1
18 thrombocytosis 29.4 F3 SELP SERPINC1
19 stroke, ischemic 29.4 F3 SELP SERPINC1
20 antiphospholipid syndrome 28.7 CD40LG F10 F3 SELP SERPINC1
21 myocardial infarction 28.4 CD40LG F10 F3 SELP SERPINC1
22 thrombocytopenia 11.3
23 complement hyperactivation, angiopathic thrombosis, and protein-losing enteropathy 10.8
24 blood group, i system 10.4
25 cerebritis 10.3
26 hantavirus pulmonary syndrome 10.3 CD40LG F3
27 splenic disease 10.3 CD40LG F3
28 caffey disease 10.2 CD40LG F3
29 endocardium disease 10.2 CD40LG F3
30 scrub typhus 10.2 CD40LG F3
31 aneurysm 10.2
32 intracranial sinus thrombosis 10.2 F3 SERPINC1
33 intestinal impaction 10.2 F3 SERPINC1
34 giant hemangioma 10.2 F3 SERPINC1
35 primary thrombocytopenia 10.2 CD40LG SELP
36 blue toe syndrome 10.2 F3 SERPINC1
37 intracranial embolism 10.2 F3 SERPINC1
38 angina pectoris 10.2 F3 SERPINC1
39 severe hemophilia a 10.2 F3 FCGR2A
40 ehrlichiosis 10.2 CD40LG SELP
41 purpura fulminans 10.1 F3 SERPINC1
42 inherited blood coagulation disease 10.1 F3 SERPINC1
43 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.1
44 paroxysmal nocturnal hemoglobinuria 10.1
45 hemoglobinuria 10.1
46 syphilitic meningitis 10.1 CD40LG SERPINC1
47 intracranial thrombosis 10.1 F3 SERPINC1
48 thrombasthenia 10.1 F3 SELP
49 hepatic infarction 10.1 F3 SERPINC1
50 prothrombin deficiency 10.1 F3 SERPINC1

Graphical network of the top 20 diseases related to Heparin-Induced Thrombocytopenia:



Diseases related to Heparin-Induced Thrombocytopenia

Symptoms & Phenotypes for Heparin-Induced Thrombocytopenia

MGI Mouse Phenotypes related to Heparin-Induced Thrombocytopenia:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.55 CD40LG F10 F3 SELP SERPINC1
2 hematopoietic system MP:0005397 9.35 CD40LG F3 FCGR2A SELP SERPINC1
3 mortality/aging MP:0010768 9.1 CD40LG F10 F3 FCGR2A SELP SERPINC1

Drugs & Therapeutics for Heparin-Induced Thrombocytopenia

Drugs for Heparin-Induced Thrombocytopenia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 63)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 9005-49-6 46507594 772
2 Fondaparinux Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 104993-28-4
3
Bivalirudin Approved, Investigational Phase 4,Phase 3 128270-60-0 16129704
4 Certoparin Approved, Investigational Phase 4
5
Dalteparin Approved Phase 4,Phase 3,Phase 2,Phase 1 9005-49-6
6
Argatroban Approved, Investigational Phase 4,Phase 3,Phase 2 74863-84-6 152951
7 Nadroparin Approved, Investigational Phase 4 9041-08-1
8
Desirudin Approved Phase 4,Phase 2,Phase 3 120993-53-5
9
Lepirudin Approved Phase 4 138068-37-8, 120993-53-5 16132441
10
Thrombin Approved, Investigational Phase 4,Phase 3,Phase 2
11
Warfarin Approved Phase 4,Phase 3,Phase 2 81-81-2 54678486 6691
12 calcium heparin Phase 4,Phase 3,Phase 2,Phase 1
13
protease inhibitors Phase 4,Phase 3,Phase 2,Phase 1
14 Fibrinolytic Agents Phase 4,Phase 3,Phase 2,Phase 1
15 Serine Proteinase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
16 Thromboplastin Phase 4,Phase 3,Phase 2
17 Heparin, Low-Molecular-Weight Phase 4,Phase 3,Phase 2,Phase 1
18 Hirudins Phase 4,Phase 3,Phase 2
19 HIV Protease Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
20 PENTA Phase 4,Phase 3,Phase 2,Phase 1
21 Anticoagulants Phase 4,Phase 3,Phase 2,Phase 1
22 Immunoglobulins Phase 4,Phase 3,Phase 1
23 Factor Xa Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
24 Antibodies Phase 4,Phase 3,Phase 1
25 Antithrombin III Phase 4,Phase 3,Phase 2,Phase 1
26 Antithrombins Phase 4,Phase 3,Phase 2,Phase 1
27 Calcium, Dietary Phase 4,Phase 3,Phase 2,Phase 1
28 Platelet Aggregation Inhibitors Phase 4,Phase 3,Phase 2
29 Liver Extracts Phase 4
30 Platelet Factor 4 Phase 4
31
Bilirubin Phase 4 635-65-4 5280352
32 Coagulants Phase 4
33 serine Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1
34
Benzocaine Approved, Investigational Phase 3 1994-09-7, 94-09-7 2337
35
Rivaroxaban Approved Phase 3,Phase 2 366789-02-8
36
Ethanol Approved Phase 3 64-17-5 702
37 tannic acid Approved, Nutraceutical Phase 3
38 Kava Approved, Investigational, Nutraceutical Phase 2, Phase 3 9000-38-8
39
Creatine Approved, Investigational, Nutraceutical Phase 2, Phase 3 57-00-1 586
40
Citric Acid Approved, Nutraceutical, Vet_approved Phase 3 77-92-9 311
41 Central Nervous System Depressants Phase 3
42 Pharmaceutical Solutions Phase 3
43 Anti-Infective Agents Phase 3
44 Anti-Infective Agents, Local Phase 3
45 Citrate Nutraceutical Phase 3
46
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
47
Carboplatin Approved Phase 2 41575-94-4 10339178 38904 498142
48 Albumin-Bound Paclitaxel Phase 2
49 Antimitotic Agents Phase 2
50 Antineoplastic Agents, Phytogenic Phase 2

Interventional clinical trials:

(show top 50) (show all 62)

# Name Status NCT ID Phase Drugs
1 The HIT-TRAP Trial Unknown status NCT00196417 Phase 4 Standard heparin (UFH) versus certoparin (LMWH)
2 Efficacy and Safety of Heparin-coated Surface-treated Polyacrylonitrile Membrane Hemofilter in Critical Ill CRRT Patients Unknown status NCT02355873 Phase 4
3 Impact of Heparin on the Need for Mechanical Ventilation in Neonates Unknown status NCT00196469 Phase 4 heparin
4 Bivalirudin PCI Registry in Heparin Induced Thrombocytopenia/Heparin Induced Thrombocytopenia and Thrombosis Syndrome (HIT/HITTS) Patients Completed NCT00759083 Phase 4 bivalirudin
5 Evaluation of Argatroban Injection in Pediatric Patients Requiring Anticoagulant Alternatives to Heparin Completed NCT00039858 Phase 4 Argatroban
6 Venous Thromboembolic Prophylaxis After Trauma: Three Times a Day Unfractionated Heparin Versus Twice a Day Enoxaparin Completed NCT01729559 Phase 4 5000 Units unfractionated Heparin Q 8 hr;30mg enoxaparin Q12 hr
7 Nadroparin for the Initial Treatment of Pulmonary Thromboembolism Completed NCT00796692 Phase 4 Nadroparin;Unfractionated heparin(UFH)
8 Study to Evaluate the Mortality Reduction of Enoxaparin in Hospitalized Acutely Ill Medical Receiving Enoxaparin Completed NCT00622648 Phase 4 Enoxaparin;Placebo
9 EXCLAIM:Extended Prophylaxis for Venous ThromboEmbolism (VTE) in Acutely Ill Medical Patients With Prolonged Immobilization Completed NCT00077753 Phase 4 enoxaparin sodium
10 Safety Study of Desirudin, an Anticoagulant for the Prophylaxis of Thrombosis Completed NCT00913133 Phase 4 Desirudin
11 A Comparative Sudy Comparing Argatroban® IV vs Desirudin SC for Suspected HIT With or Without Thrombosis Syndrome Terminated NCT00787332 Phase 4 Desirudin or Argatroban®
12 Argatroban Versus Lepirudin in Critically Ill Patients Terminated NCT00798525 Phase 4 Argatroban;Lepirudin
13 Significance of Antibodies to Heparin/Platelet Factor 4 Complex in Vein Graft Patency and Potential Role of Argatroban for Prevention of Vein Graft Occlusion Terminated NCT01246011 Phase 4 Argatroban and warfarin
14 Fondaparinux in Patients With Acute Heparin-Induced Thrombocytopenia (HIT) Withdrawn NCT00603824 Phase 4 fondaparinux;argatroban or lepirudin
15 Angiomax in Patients With HIT/HITTS Type II Undergoing Off-Pump Coronary Artery Bypass Grafting (CABG) (CHOOSE) Unknown status NCT00073580 Phase 3 Angiomax (bivalirudin) anticoagulant
16 Fondaparinux to Prevent Thrombotic Complications and Graft Failure in Patients Undergoing Coronary Artery Bypass Graft Surgery: The Fonda CABG Study Unknown status NCT00474591 Phase 3 Fondaparinux
17 Efficacy and Safety Study of Argatroban to Treat Heparin-Induced Thrombocytopenia Completed NCT00198588 Phase 3 argatroban
18 Anticoagulant Therapy With Bivalirudin in the Performance of Percutaneous Coronary Intervention in Patients With Heparin-Induced Thrombocytopenia (AT BAT, First Inning) Completed NCT00043940 Phase 3 bivalirudin
19 Angiomax in Patients With HIT/HITTS Type II Undergoing CPB Completed NCT00079508 Phase 3 Angiomax (bivalirudin)
20 PROphylaxis for ThromboEmbolism in Critical Care Trial (PROTECT) Completed NCT00182143 Phase 3 LMWH (Fragmin, dalteparin);Unfractionated Heparin
21 Heparin 100U/L for Prevention of PVC Complications Completed NCT01131754 Phase 3
22 The Use of Fondaparinux in Preventing Thromboembolism in High Risk Trauma Patients Completed NCT00531843 Phase 2, Phase 3 fondaparinux sodium
23 Study Comparing Desirudin With Heparin to Prevent Vein Clots After Heart and Lung Surgery Completed NCT00329433 Phase 2, Phase 3 Desirudin (Iprivask™);Heparin
24 PROSPER: PostpaRtum PrOphylaxiS for PE Randomized Control Trial Pilot Completed NCT01274637 Phase 3 Dalteparin Sodium
25 A Safety and Efficacy Study of BCD-080 Compared to Clexan for Deep Vein Thrombosis Prophylaxis at Orthopedic Surgeries Completed NCT02368314 Phase 3 Sodium Enoxaparine
26 Multi-Center Single Arm Trial to Determine The Effectiveness of Warfarin Therapy Duration For Heparin-Induced Thrombocytopenia (HIT) Recruiting NCT03147638 Phase 3 Warfarin, NOAC
27 Evaluation of the Efficacy of an inTerdialytic "Ethanol 40% v/v - enoxapaRin 1000 U/mL" Lock solutioN to Prevent Tunnelled Catheter Infections in Chronic Hemodialysis Patients Not yet recruiting NCT03083184 Phase 3 Ethanol;enoxaparin
28 Rivaroxaban for Treatment of Patients With Suspected or Confirmed Heparin-Induced Thrombocytopenia Terminated NCT01598168 Phase 3 Rivaroxaban
29 Clinical Management of Argatroban in Patients With Heparin Induced Thrombocytopenia Type II Completed NCT00861692 Phase 2 argatroban
30 ODiXahip - a Phase IIa Dose Escalating Proof of Principle Trial Completed NCT00839826 Phase 2 Rivaroxaban (BAY59-7939);Enoxaparin
31 Addition of Enoxaparin to Neoadjuvant Chemoradiation of Esophageal Cancer Recruiting NCT03254511 Phase 2 Enoxaparin Sodium 40 MG/0.2 ML Subcutaneous Injectable;Chemotherapeutic Combinations
32 Aneurysmal Subarachnoid Hemorrhage Trial RandOmizing Heparin Recruiting NCT02501434 Phase 2 Continuous Low-Dose IV Unfractionated Heparin Infusion
33 Extended Low-Molecular Weight Heparin VTE Prophylaxis in Thoracic Surgery Recruiting NCT02334007 Phase 1, Phase 2 LMWH: Dalteparin
34 Catheter-Related Early Thromboprophylaxis With Enoxaparin (CRETE) Trial Recruiting NCT03003390 Phase 2 Enoxaparin
35 Heparin Anticoagulation in Septic Shock Not yet recruiting NCT03378466 Phase 2 Unfractionated heparin
36 Fondaparinux for the Treatment of Heparin-Induced Thrombocytopenia (HIT) Terminated NCT00673439 Phase 2 fondaparinux;warfarin
37 Heparin-Induced Thrombocytopenia Score Card Study Completed NCT00489437 Phase 1
38 Pilot Dose Finding and Pharmacokinetic Study of Fondaparinux in Children With Thrombosis Completed NCT00412464 Phase 1 Fondaparinux
39 Validating 4Ts for Heparin Induced Thrombocytopenia (HIT) Unknown status NCT00946400
40 A Study on the Prevalence of Heparin-Induced Thrombocytopenia in Cardiovascular Patients Unknown status NCT00198575
41 Generation of Heparin-induced Thrombocytopenia (HIT)-Antibodies Without Prior Heparin Exposure Unknown status NCT01102790
42 Incidence and Nature of Heparin-induced Skin Lesions in Medical Patients Unknown status NCT00510432
43 Need for Antepartum Thromboprophylaxis in Pregnant Women With One Prior Episode of Venous Thromboembolism (VTE) Unknown status NCT01357941
44 Rapid Diagnosis of Heparin-Induced Thrombocytopenia in Surgical Critically Ill Patients Completed NCT02790567
45 Heparin-Induced Thrombocytopenia Registry Completed NCT00456326
46 Heparin-induced Thrombocytopenia (HIT II) in Liver Transplant Recipients Completed NCT01654848
47 Heparin-Induced Thrombocytopenia: Development and Validation of a Predictive Clinical Completed NCT00748839
48 Heparin Induced Thrombocytopenia: Pharmacoeconomics Completed NCT00456001
49 Heparin-Induced Thrombocytopenia - Retrospective Analysis of Data on Incidence and Outcomes Study Completed NCT01178333
50 Retrospective Registry of Patients With Acute Heparin-induced Thrombocytopenia Type II Completed NCT01304238 lepirudin;danaparoid;argatroban;fondaparinux

Search NIH Clinical Center for Heparin-Induced Thrombocytopenia

Genetic Tests for Heparin-Induced Thrombocytopenia

Anatomical Context for Heparin-Induced Thrombocytopenia

MalaCards organs/tissues related to Heparin-Induced Thrombocytopenia:

38
Testes, Liver, Heart, Skin, Lung, Monocytes, Endothelial

Publications for Heparin-Induced Thrombocytopenia

Articles related to Heparin-Induced Thrombocytopenia:

(show top 50) (show all 837)
# Title Authors Year
1
Abciximab/Heparin During Acute Heparin-Induced Thrombocytopenia: A Word of Caution. ( 29305853 )
2018
2
Successful Use of Intravenous Immunoglobulin G to Treat Refractory Heparin-Induced Thrombocytopenia With Thrombosis Complicating Peripheral Blood Stem Cell Harvest. ( 29404376 )
2018
3
Heparin-induced thrombocytopenia complicating children after the Fontan procedure: Single-center experience and review of the literature. ( 29181882 )
2018
4
Platelet-Activating Antibodies Are Detectable at the Earliest Onset of Heparin-Induced Thrombocytopenia, With Implications for the Operating Characteristics of the Serotonin-Release Assay. ( 29325985 )
2018
5
Abciximab/Heparin During Acute Heparin-induced Thrombocytopenia: A Word of Caution (Reply). ( 29371038 )
2018
6
Phlegmasia Cerulea Dolens Following Heparin-Induced Thrombocytopenia. ( 29422736 )
2018
7
Heparin-Induced Thrombocytopenia during Obstetric Hospital Admissions. ( 29421832 )
2018
8
Laboratory tests for identification or exclusion of heparin induced thrombocytopenia: HIT or miss? ( 29164662 )
2018
9
Initial and long term impact of a multi-disciplinary task force in the diagnosis and management of heparin-induced thrombocytopenia. ( 29185142 )
2018
10
Delayed-onset heparin-induced thrombocytopenia complicated by arterial and venous thromboses. ( 29314517 )
2018
11
Use of systemic bivalirudin with catheter-directed thrombolysis in a patient with heparin-induced thrombocytopenia: A case report. ( 29068112 )
2017
12
Evaluation of 4T's scoring system in the identification of heparin-induced thrombocytopenia in patients with mechanical circulatory support. ( 29112890 )
2017
13
Effectiveness of a Laboratory Gate-Keeping Strategy to Overcome Inappropriate Test Utilization for the Diagnosis of Heparin-Induced Thrombocytopenia. ( 28750423 )
2017
14
Is low serum albumin level a significant predictor for the development of heparin-induced thrombocytopenia-thrombosis? ( 28289828 )
2017
15
Treatment of pulmonary embolism with argatroban and ultrasound-assisted catheter-directed thrombolysis with alteplase in a patient with heparin-induced thrombocytopenia. ( 28743779 )
2017
16
Performance of 4T score and heparin-platelet factor 4 antibody in the diagnosis of heparin-induced thrombocytopenia (HIT) in cancer. ( 28677022 )
2017
17
Heparin-Induced Thrombocytopenia and Vascular Surgery. ( 28807578 )
2017
18
Incidence and Outcomes of Heparin-Induced Thrombocytopenia in Patients Undergoing Vascular Surgery. ( 28864160 )
2017
19
Argatroban for Heparin-Induced Thrombocytopenia during Venovenous Extracorporeal Membrane Oxygenation with Continuous Venovenous Hemofiltration. ( 28638161 )
2017
20
Extensive Intracardiac and Deep Venous Thromboses in a Young Woman with Heparin-Induced Thrombocytopenia and May-Thurner Syndrome. ( 28465848 )
2017
21
Management of refractory bleeding post-cardiopulmonary bypass in an acute heparin-induced thrombocytopenia type II renal failure patient who underwent urgent cardiac surgery with bivalirudin (Angiox(Ar)) anticoagulation. ( 28789610 )
2017
22
Cerebral Venous Sinus Thrombosis Due to Low-molecular-weight Heparin-induced Thrombocytopenia. ( 29095327 )
2017
23
False positive immunoassay for heparin-induced thrombocytopenia in the presence of monoclonal gammopathy: a case report. ( 29180919 )
2017
24
IV Immunoglobulin forA Autoimmune Heparin-Induced Thrombocytopenia. ( 28889872 )
2017
25
5B9, a monoclonal antiplatelet factor 4/heparin IgG with a human Fc fragment that mimics heparin-induced thrombocytopenia antibodies. ( 28771917 )
2017
26
Low dose bivalirudin anticoagulation for lung transplantation with extracorporeal membrane oxygenation in a patient with acute heparin-induced thrombocytopenia. ( 28043990 )
2017
27
Delayed Seroconversion in a Patient With Heparin-Induced Thrombocytopenia. ( 29336969 )
2017
28
Laboratory Testing Protocols for Heparin-Induced Thrombocytopenia (HIT) Testing. ( 28804833 )
2017
29
Autoimmune heparin-induced thrombocytopenia. ( 28846826 )
2017
30
Can rivaroxaban be a drug of choice for treating heparin-induced thrombocytopenia in a patient with pulmonary thromboembolism? ( 28680014 )
2017
31
Apixaban for treatment of confirmed heparin-induced thrombocytopenia: a case report and review of literature. ( 28725494 )
2017
32
Clinical effectiveness of a Bayesian algorithm for the diagnosis and management of heparin-induced thrombocytopenia. ( 28622439 )
2017
33
Heparin-Induced Thrombocytopenia in the Critically Ill Patient. ( 29253554 )
2017
34
Influence of Human Leukocyte Antigen (HLA) Alleles and Killer Cell Immunoglobulin-Like Receptors (KIR) Types on Heparin-Induced Thrombocytopenia (HIT). ( 28688202 )
2017
35
The Clinical Utility of the Heparin Neutralization Assay in the Diagnosis of Heparin-Induced Thrombocytopenia. ( 28774196 )
2017
36
Hydrophilic Polymer Embolism in the Lung as an Adverse Eventa88- Autopsy Case of Thromboembolisms in Multiple Organs Associated With Heparin-Induced Thrombocytopenia. ( 28626145 )
2017
37
Direct acting oral anticoagulants for the treatment of suspected heparin-induced thrombocytopenia. ( 28672052 )
2017
38
Use of Fondaparinux Off-Label or Approved Anticoagulants for Management of Heparin-Induced Thrombocytopenia. ( 29169470 )
2017
39
The Role of Apixaban in the Treatment of Heparin-Induced Thrombocytopenia. ( 28884054 )
2017
40
Evaluation of a Reflex Testing Algorithm for Suspected Heparin-Induced Thrombocytopenia. ( 29059268 )
2017
41
Activated platelet-derived and leukocyte-derived circulating microparticles and the risk of thrombosis in heparin-induced thrombocytopenia: A role for pf4-bearing microparticles? ( 28052584 )
2017
42
Heparin-Induced Thrombocytopenia and Thrombosis: Preventing your Thrombolysis Practice from Taking a HITT. ( 29249865 )
2017
43
Fondaparinux for Treatment of Heparin-Induced Thrombocytopenia: Too Good to Be True? ( 29169471 )
2017
44
Persistent Heparin-Induced Thrombocytopenia Treated With IVIg. ( 28889885 )
2017
45
Optical Coherence Tomography Findings in Early Stent Thrombosis by Heparin-Induced Thrombocytopenia. ( 27818479 )
2016
46
Heparin-induced thrombocytopenia in 2017 and beyond. ( 27734071 )
2016
47
Spontaneous heparin-induced thrombocytopenia (HIT) syndrome: HIT without any heparin exposure. ( 27795522 )
2016
48
TCT-216 Bivalrudin vs. Argatroban for treatment of Heparin-induced Thrombocytopenia: A Meta-analysis. ( 27970391 )
2016
49
Massive Pulmonary Embolism in a Patient with Heparin Induced Thrombocytopenia: Successful Treatment with Dabigatran. ( 27026768 )
2016
50
Inappropriate documentation of heparin allergy in the medical record because of misdiagnosis of heparin-induced thrombocytopenia: frequency and consequences. ( 28012249 )
2016

Variations for Heparin-Induced Thrombocytopenia

Expression for Heparin-Induced Thrombocytopenia

Search GEO for disease gene expression data for Heparin-Induced Thrombocytopenia.

Pathways for Heparin-Induced Thrombocytopenia

GO Terms for Heparin-Induced Thrombocytopenia

Cellular components related to Heparin-Induced Thrombocytopenia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.43 CD40LG F10 F3 FCGR2A SELP SERPINC1
2 intrinsic component of external side of plasma membrane GO:0031233 8.62 F10 F3

Biological processes related to Heparin-Induced Thrombocytopenia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 9.33 F10 F3 SERPINC1
2 leukocyte cell-cell adhesion GO:0007159 9.26 CD40LG SELP
3 blood coagulation, extrinsic pathway GO:0007598 8.96 F10 F3
4 hemostasis GO:0007599 8.8 F10 F3 SERPINC1

Molecular functions related to Heparin-Induced Thrombocytopenia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 8.96 F3 SERPINC1
2 phospholipid binding GO:0005543 8.62 F10 F3

Sources for Heparin-Induced Thrombocytopenia

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