HAT
MCID: HPR003
MIFTS: 45

Heparin-Induced Thrombocytopenia (HAT) malady

Categories: Rare diseases, Blood diseases

Aliases & Classifications for Heparin-Induced Thrombocytopenia

Aliases & Descriptions for Heparin-Induced Thrombocytopenia:

Name: Heparin-Induced Thrombocytopenia 50 56 69
Hit 50 56
Heparin-Induced Thrombocytopenia Type 2 56
Heparin-Associated Thrombocytopenia 56
Hat 56

Characteristics:

Orphanet epidemiological data:

56
heparin-induced thrombocytopenia
Inheritance: Not applicable; Age of onset: All ages;

Classifications:



External Ids:

Orphanet 56 ORPHA3325
UMLS via Orphanet 70 C0272285
ICD10 via Orphanet 34 D69.5

Summaries for Heparin-Induced Thrombocytopenia

NIH Rare Diseases : 50 heparin-induced thrombocytopenia (hit) is an adverse reaction to the drug heparin resulting in an abnormally low amount of platelets (thrombocytopenia). hit is usually an immune response which typically occurs 4-10 days after exposure to heparin; it can lead to serious complications and be life-threatening. this condition occurs in up to 5% of those who are exposed to heparin. characteristic signs of hit are a drop in platelet count of  greater than 50% and/or the formation of new blood clots during heparin therapy.  the first step of treatment is to discontinue and avoid all heparin products immediately. often, affected individuals require another medicine to prevent blood clotting (anticoagulants). last updated: 5/3/2012

MalaCards based summary : Heparin-Induced Thrombocytopenia, also known as hit, is related to budd-chiari syndrome and essential thrombocythemia. An important gene associated with Heparin-Induced Thrombocytopenia is F3 (Coagulation Factor III, Tissue Factor), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Heparin and Bivalirudin have been mentioned in the context of this disorder. Affiliated tissues include testes, heart and liver, and related phenotypes are cardiovascular system and hematopoietic system

Wikipedia : 71 Heparin-induced thrombocytopenia (HIT) is the development of thrombocytopenia (a low platelet count),... more...

Related Diseases for Heparin-Induced Thrombocytopenia

Diseases related to Heparin-Induced Thrombocytopenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 143)
id Related Disease Score Top Affiliating Genes
1 budd-chiari syndrome 30.1 F3 SELP SERPINC1
2 essential thrombocythemia 30.0 F3 SERPINC1
3 lupus erythematosus 29.9 F3 SELP SERPINC1
4 myocardial infarction 29.7 F10 F3 SELP SERPINC1
5 pericarditis 29.5 F3 SELP SERPINC1
6 myeloproliferative neoplasm 28.9 CD40LG F10 F3 SELP SERPINC1
7 thrombocytopenia 11.2
8 thrombosis 10.7
9 pulmonary embolism 10.3
10 cerebritis 10.2
11 antiphospholipid syndrome 10.2
12 acrodysplasia scoliosis 10.2 F10 F3
13 myotonic dystrophy 10.2 F10 F3
14 prostatic hypertrophy 10.2 F3 SELP
15 sporotrichosis 10.2 CD40LG F3
16 chronic inflammatory demyelinating polyneuritis 10.2 CD40LG F3
17 central congenital hypothyroidism 10.2 CD40LG F3
18 megaloblastic anemia 10.1 CD40LG F3
19 ceroid lipofuscinosis, neuronal, 11 10.1 CD40LG F3
20 microphthalmia, isolated, with coloboma 10 10.1 F10 SELP
21 sertoli cell tumor 10.1 F3 SERPINC1
22 influenza 10.1 F3 SERPINC1
23 pancreatic ductal carcinoma 10.1 F3 SERPINC1
24 otopalatodigital syndrome, type i 10.1 F10 F3
25 mixed hepatoblastoma 10.1 F3 SERPINC1
26 artery disease 10.1 CD40LG F3
27 hypertrichosis 10.1 F3 SERPINC1
28 dmd-related dilated cardiomyopathy 10.1 F3 SERPINC1
29 spinal cord lipoma 10.1 F3 SERPINC1
30 midline cystocele 10.1 F3 SERPINC1
31 thyroid cancer, anaplastic 10.1 F3 SELP
32 mental depression 10.1 CD40LG SELP
33 neuronopathy, distal hereditary motor, type iid 10.1 F3 SERPINC1
34 lung combined large cell neuroendocrine carcinoma 10.1 CD40LG F3
35 secretory diarrhea myopathy and deafness 10.1 F3 SERPINC1
36 conjunctivochalasis 10.1 F3 SERPINC1
37 ductal carcinoma in situ 10.1 F3 SERPINC1
38 aneurysm 10.1
39 monocular exotropia 10.1 F3 SERPINC1
40 severe nonproliferative diabetic retinopathy 10.1 CD40LG SELP
41 blepharoconjunctivitis 10.1 F3 SERPINC1
42 intestinal disaccharidase deficiency 10.1 F3 SERPINC1
43 cysticercosis 10.1 CD40LG SERPINC1
44 zika virus congenital syndrome 10.1 F3 SERPINC1
45 capillary hemangioma 10.1 F3 SERPINC1
46 oropharyngeal anthrax 10.1 CD40LG SERPINC1
47 atrophic nonflaccid tympanic membrane 10.1 F3 SELP
48 paroxysmal nocturnal hemoglobinuria 10.1
49 hemoglobinuria 10.1
50 osteogenesis imperfecta, type vii 10.1 CD40LG SELP

Graphical network of the top 20 diseases related to Heparin-Induced Thrombocytopenia:



Diseases related to Heparin-Induced Thrombocytopenia

Symptoms & Phenotypes for Heparin-Induced Thrombocytopenia

MGI Mouse Phenotypes related to Heparin-Induced Thrombocytopenia:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.65 CD40LG F10 F3 SELP SERPINC1
2 hematopoietic system MP:0005397 9.55 CD40LG F3 FCGR2A SELP SERPINC1
3 immune system MP:0005387 9.35 CD40LG F3 FCGR2A SELP SERPINC1
4 mortality/aging MP:0010768 9.1 CD40LG F10 F3 FCGR2A SELP SERPINC1

Drugs & Therapeutics for Heparin-Induced Thrombocytopenia

Drugs for Heparin-Induced Thrombocytopenia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 55)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 9005-49-6 772 46507594
2
Bivalirudin Approved, Investigational Phase 4,Phase 3 128270-60-0 16129704
3 Certoparin Approved Phase 4
4
Dalteparin Approved Phase 4,Phase 3,Phase 1,Phase 2 9041-08-1
5
Argatroban Approved, Investigational Phase 4,Phase 3,Phase 2 74863-84-6 152951
6 Nadroparin Approved Phase 4 9041-08-1
7
Desirudin Approved Phase 4,Phase 2,Phase 3 120993-53-5
8
Lepirudin Approved Phase 4 120993-53-5, 138068-37-8 16132441
9
Warfarin Approved Phase 4,Phase 3,Phase 2 81-81-2 6691 54678486
10 fondaparinux Phase 4,Phase 3,Phase 2,Phase 1
11 calcium heparin Phase 4,Phase 3,Phase 2,Phase 1
12
protease inhibitors Phase 4,Phase 3,Phase 2
13 Serine Proteinase Inhibitors Phase 4,Phase 3,Phase 2
14 HIV Protease Inhibitors Phase 4,Phase 3,Phase 2
15 Thromboplastin Phase 4,Phase 3
16 Heparin, Low-Molecular-Weight Phase 4,Phase 3,Phase 1,Phase 2
17 Hirudins Phase 4,Phase 3,Phase 2
18 PENTA Phase 4,Phase 3,Phase 2,Phase 1
19 Immunoglobulins Phase 4,Phase 3,Phase 1
20 Fibrinolytic Agents Phase 4,Phase 3,Phase 2,Phase 1
21 Anticoagulants Phase 4,Phase 3,Phase 2,Phase 1
22 Antibodies Phase 4,Phase 3,Phase 1
23 Antithrombin III Phase 4,Phase 3,Phase 2
24 Antithrombins Phase 4,Phase 3,Phase 2
25 Calcium, Dietary Phase 4,Phase 3,Phase 2,Phase 1
26 Thrombin Phase 4,Phase 3,Phase 2
27 Platelet Aggregation Inhibitors Phase 4,Phase 3,Phase 2
28 Liver Extracts Phase 4
29 Platelet Factor 4 Phase 4
30
Bilirubin Phase 4 635-65-4 5280352
31 Coagulants Phase 4
32 serine Nutraceutical Phase 4,Phase 3,Phase 2
33
Benzocaine Approved Phase 3 1994-09-7, 94-09-7 2337
34
Rivaroxaban Approved Phase 3,Phase 2 366789-02-8
35
Ethanol Approved Phase 3 64-17-5 702
36 tannic acid Approved, Nutraceutical Phase 3
37
Creatine Approved, Nutraceutical Phase 2, Phase 3 57-00-1 586
38 Factor Xa Inhibitors Phase 3,Phase 2
39 Pharmaceutical Solutions Phase 3
40 Anti-Infective Agents Phase 3
41 Anti-Infective Agents, Local Phase 3
42 Central Nervous System Depressants Phase 3
43 Kava Nutraceutical Phase 2, Phase 3 9000-38-8
44 Citrate Nutraceutical Phase 3
45
Citric Acid Nutraceutical, Vet_approved Phase 3 77-92-9 311
46
Serotonin Phase 1 50-67-9 5202
47
Tinzaparin Approved 9005-49-6, 9041-08-1 25244225
48
Menthol Approved 2216-51-5 16666
49 Heparinoids
50 Dermatan Sulfate

Interventional clinical trials:

(show top 50) (show all 59)
id Name Status NCT ID Phase
1 The HIT-TRAP Trial Unknown status NCT00196417 Phase 4
2 Efficacy and Safety of Heparin-coated Surface-treated Polyacrylonitrile Membrane Hemofilter in Critical Ill CRRT Patients Unknown status NCT02355873 Phase 4
3 Impact of Heparin on the Need for Mechanical Ventilation in Neonates Unknown status NCT00196469 Phase 4
4 Bivalirudin PCI Registry in Heparin Induced Thrombocytopenia/Heparin Induced Thrombocytopenia and Thrombosis Syndrome (HIT/HITTS) Patients Completed NCT00759083 Phase 4
5 Evaluation of Argatroban Injection in Pediatric Patients Requiring Anticoagulant Alternatives to Heparin Completed NCT00039858 Phase 4
6 Venous Thromboembolic Prophylaxis After Trauma: Three Times a Day Unfractionated Heparin Versus Twice a Day Enoxaparin Completed NCT01729559 Phase 4
7 Nadroparin for the Initial Treatment of Pulmonary Thromboembolism Completed NCT00796692 Phase 4
8 Study to Evaluate the Mortality Reduction of Enoxaparin in Hospitalized Acutely Ill Medical Receiving Enoxaparin Completed NCT00622648 Phase 4
9 EXCLAIM:Extended Prophylaxis for Venous ThromboEmbolism (VTE) in Acutely Ill Medical Patients With Prolonged Immobilization Completed NCT00077753 Phase 4
10 Safety Study of Desirudin, an Anticoagulant for the Prophylaxis of Thrombosis Completed NCT00913133 Phase 4
11 A Comparative Sudy Comparing Argatroban® IV vs Desirudin SC for Suspected HIT With or Without Thrombosis Syndrome Terminated NCT00787332 Phase 4
12 Argatroban Versus Lepirudin in Critically Ill Patients Terminated NCT00798525 Phase 4
13 Significance of Antibodies to Heparin/Platelet Factor 4 Complex in Vein Graft Patency and Potential Role of Argatroban for Prevention of Vein Graft Occlusion Terminated NCT01246011 Phase 4
14 Fondaparinux in Patients With Acute Heparin-Induced Thrombocytopenia (HIT) Withdrawn NCT00603824 Phase 4
15 Angiomax in Patients With HIT/HITTS Type II Undergoing Off-Pump Coronary Artery Bypass Grafting (CABG) (CHOOSE) Unknown status NCT00073580 Phase 3
16 Fondaparinux to Prevent Thrombotic Complications and Graft Failure in Patients Undergoing Coronary Artery Bypass Graft Surgery: The Fonda CABG Study Unknown status NCT00474591 Phase 3
17 Efficacy and Safety Study of Argatroban to Treat Heparin-Induced Thrombocytopenia Completed NCT00198588 Phase 3
18 Anticoagulant Therapy With Bivalirudin in the Performance of Percutaneous Coronary Intervention in Patients With Heparin-Induced Thrombocytopenia (AT BAT, First Inning) Completed NCT00043940 Phase 3
19 Angiomax in Patients With HIT/HITTS Type II Undergoing CPB Completed NCT00079508 Phase 3
20 PROphylaxis for ThromboEmbolism in Critical Care Trial (PROTECT) Completed NCT00182143 Phase 3
21 The Use of Fondaparinux in Preventing Thromboembolism in High Risk Trauma Patients Completed NCT00531843 Phase 2, Phase 3
22 Heparin 100U/L for Prevention of PVC Complications Completed NCT01131754 Phase 3
23 Study Comparing Desirudin With Heparin to Prevent Vein Clots After Heart and Lung Surgery Completed NCT00329433 Phase 2, Phase 3
24 PROSPER: PostpaRtum PrOphylaxiS for PE Randomized Control Trial Pilot Completed NCT01274637 Phase 3
25 A Safety and Efficacy Study of BCD-080 Compared to Clexan for Deep Vein Thrombosis Prophylaxis at Orthopedic Surgeries Completed NCT02368314 Phase 3
26 Multi-Center Single Arm Trial to Determine The Effectiveness of Warfarin Therapy Duration For Heparin-Induced Thrombocytopenia (HIT) Recruiting NCT03147638 Phase 3
27 Evaluation of the Efficacy of an inTerdialytic "Ethanol 40% v/v - enoxapaRin 1000 U/mL" Lock solutioN to Prevent Tunnelled Catheter Infections in Chronic Hemodialysis Patients Not yet recruiting NCT03083184 Phase 3
28 Rivaroxaban for Treatment of Patients With Suspected or Confirmed Heparin-Induced Thrombocytopenia Terminated NCT01598168 Phase 3
29 Clinical Management of Argatroban in Patients With Heparin Induced Thrombocytopenia Type II Completed NCT00861692 Phase 2
30 ODiXahip - a Phase IIa Dose Escalating Proof of Principle Trial Completed NCT00839826 Phase 2
31 Aneurysmal Subarachnoid Hemorrhage Trial RandOmizing Heparin Recruiting NCT02501434 Phase 2
32 Thoracic Surgery Extended Low-Molecular Weight Heparin VTE Prophylaxis--Pilot Trial Recruiting NCT02334007 Phase 1, Phase 2
33 Catheter-Related Early Thromboprophylaxis With Enoxaparin (CRETE) Trial Recruiting NCT03003390 Phase 2
34 Fondaparinux for the Treatment of Heparin-Induced Thrombocytopenia (HIT) Terminated NCT00673439 Phase 2
35 Heparin-Induced Thrombocytopenia Score Card Study Completed NCT00489437 Phase 1
36 Pilot Dose Finding and Pharmacokinetic Study of Fondaparinux in Children With Thrombosis Completed NCT00412464 Phase 1
37 Validating 4Ts for Heparin Induced Thrombocytopenia (HIT) Unknown status NCT00946400
38 A Study on the Prevalence of Heparin-Induced Thrombocytopenia in Cardiovascular Patients Unknown status NCT00198575
39 Generation of Heparin-induced Thrombocytopenia (HIT)-Antibodies Without Prior Heparin Exposure Unknown status NCT01102790
40 Incidence and Nature of Heparin-induced Skin Lesions in Medical Patients Unknown status NCT00510432
41 Need for Antepartum Thromboprophylaxis in Pregnant Women With One Prior Episode of Venous Thromboembolism (VTE) Unknown status NCT01357941
42 Rapid Diagnosis of Heparin-Induced Thrombocytopenia in Surgical Critically Ill Patients Completed NCT02790567
43 Heparin-Induced Thrombocytopenia Registry Completed NCT00456326
44 Heparin-Induced Thrombocytopenia: Development and Validation of a Predictive Clinical Completed NCT00748839
45 Heparin Induced Thrombocytopenia: Pharmacoeconomics Completed NCT00456001
46 Heparin-induced Thrombocytopenia (HIT II) in Liver Transplant Recipients Completed NCT01654848
47 Heparin-Induced Thrombocytopenia - Retrospective Analysis of Data on Incidence and Outcomes Study Completed NCT01178333
48 Retrospective Registry of Patients With Acute Heparin-induced Thrombocytopenia Type II Completed NCT01304238
49 Heparin Antibodies in Intensive Care Unit Patients (HAICU) Completed NCT00283322
50 Identification of Donors of CD36-Deficient Platelets Among Japanese Individuals on the NIH Campus Completed NCT00015639

Search NIH Clinical Center for Heparin-Induced Thrombocytopenia

Genetic Tests for Heparin-Induced Thrombocytopenia

Anatomical Context for Heparin-Induced Thrombocytopenia

MalaCards organs/tissues related to Heparin-Induced Thrombocytopenia:

39
Testes, Heart, Liver, Skin, Monocytes, Endothelial, Lung

Publications for Heparin-Induced Thrombocytopenia

Articles related to Heparin-Induced Thrombocytopenia:

(show top 50) (show all 793)
id Title Authors Year
1
Low dose bivalirudin anticoagulation for lung transplantation with extracorporeal membrane oxygenation in a patient with acute heparin-induced thrombocytopenia. ( 28043990 )
2017
2
Activated platelet-derived and leukocyte-derived circulating microparticles and the risk of thrombosis in heparin-induced thrombocytopenia: A role for pf4-bearing microparticles? ( 28052584 )
2017
3
Optical Coherence Tomography Findings in Early Stent Thrombosis by Heparin-Induced Thrombocytopenia. ( 27818479 )
2016
4
Platelet Activation Testing for Heparin-Induced Thrombocytopenia Antibodies: A Problem That Needs Fixing? ( 27613972 )
2016
5
Platelet Count Trends and Prevalence of Heparin-Induced Thrombocytopenia in a Cohort of Extracorporeal Membrane Oxygenator Patients. ( 27441904 )
2016
6
Heparin-induced thrombocytopenia: research and clinical updates. ( 27913490 )
2016
7
Rivaroxaban for Treatment of Suspected or Confirmed Heparin-Induced Thrombocytopenia Study. ( 27061271 )
2016
8
Rapid and durable response to intravenous immunoglobulin in delayed heparin-induced thrombocytopenia: a case report. ( 27943368 )
2016
9
Massive Pulmonary Embolism in a Patient with Heparin Induced Thrombocytopenia: Successful Treatment with Dabigatran. ( 27026768 )
2016
10
Negative Heparin-Induced Thrombocytopenia Test Result After Massive Transfusion: Believe It or Not? ( 27124942 )
2016
11
Efficacy and Safety of Fondaparinux in Patients With Suspected Heparin-Induced Thrombocytopenia. ( 27179015 )
2016
12
Novel oral anticoagulants for heparin-induced thrombocytopenia. ( 27102287 )
2016
13
Heparin-induced thrombocytopenia in solid organ transplant recipients: The current scientific knowledge. ( 27011914 )
2016
14
Acute intraoperative heparin-induced thrombocytopenia (HIT) and thrombosis during coronary artery bypass grafting: Two case reports providing evidence for the role of preoperative LMWH in triggering sensitization. ( 27597121 )
2016
15
Heparin induced thrombocytopenia presenting with deep venous thrombosis and pulmonary embolism successfully treated with rivaroxaban: clinical case report and review of current experiences. ( 27464495 )
2016
16
Cost-effectiveness of anticoagulants for suspected heparin-induced thrombocytopenia in the United States. ( 27793877 )
2016
17
Bivalirudin Anticoagulation for a Pediatric Patient with Heparin-Induced Thrombocytopenia and Thrombosis Requiring Cardiopulmonary Bypass for Ventricular Assist Device Placement. ( 27134308 )
2016
18
Immune pathogenesis of heparin-induced thrombocytopenia. ( 27465274 )
2016
19
Rivaroxaban in treatment refractory heparin-induced thrombocytopenia. ( 27520997 )
2016
20
Successful Anticoagulation Using Argatroban During Transcatheter Aortic Valve Implantation in a Patient With Heparin-Induced Thrombocytopenia. ( 27513970 )
2016
21
Screening frequency, incidence and pattern of heparin-induced thrombocytopenia syndrome at a large tertiary institution. ( 27106479 )
2016
22
Treatment of heparin-induced thrombocytopenia before and after the implementation of a hemostatic and antithrombotic stewardship program. ( 27501998 )
2016
23
Predictions and presumptive treatment of heparin-induced thrombocytopenia. ( 27147210 )
2016
24
Overtreatment of Heparin-Induced Thrombocytopenia in the Surgical ICU. ( 27513533 )
2016
25
Atomic features of an autoantigen in heparin-induced thrombocytopenia (HIT). ( 26970483 )
2016
26
Utilization of 4T score to determine the pretest probability of heparin-induced thrombocytopenia in a community hospital in upstate New York. ( 27609736 )
2016
27
Management of the multiple phases of heparin-induced thrombocytopenia. ( 27075525 )
2016
28
Rheolytic thrombectomy in patient with acute pulmonary embolism, heparin-induced thrombocytopenia and recent stoke. When percutaneous treatment is the only therapeutic alternative. ( 27113394 )
2016
29
Clinical picture of heparin-induced thrombocytopenia (HIT) and its differentiation from non-HIT thrombocytopenia. ( 27656712 )
2016
30
Rivaroxaban for heparin-induced thrombocytopenia: adding to the evidence. ( 27822611 )
2016
31
A Case of Heparin-Induced Thrombocytopenia Type 2 after Repair of Juxtarenal Abdominal Aortic Aneurysm. ( 28031678 )
2016
32
Left Main Artery Thrombus Complicating Heart Transplantation in a Patient With Heparin-Induced Thrombocytopenia. ( 27431594 )
2016
33
Argatroban for Treatment of Heparin-Induced Thrombocytopenia and Thrombosis in a Patient with Multiple Myeloma Undergoing Hemodialysis. ( 27448437 )
2016
34
Transplantation in a patient on extracorporeal membrane oxygenation with infective endocarditis, pericarditis and heparin-induced thrombocytopenia. ( 28040771 )
2016
35
Acute apixaban treatment of heparin-induced thrombocytopenia. ( 27844303 )
2016
36
Heparin-induced thrombocytopenia in cardiac surgery and critically ill patients. ( 27411507 )
2016
37
Dabigatran approaching the realm of heparin-induced thrombocytopenia. ( 27382551 )
2016
38
Evaluation of a flow cytometric assay for the confirmation of heparin-induced thrombocytopenia. ( 26991642 )
2016
39
Heparin-induced thrombocytopenia in 2017 and beyond. ( 27734071 )
2016
40
Successful intraprocedural anticoagulation with bivalirudin during pulmonary vein isolation in a patient with known heparin-induced thrombocytopenia type II. ( 27092199 )
2016
41
Single-molecule force spectroscopy applied to heparin-induced thrombocytopenia. ( 27790761 )
2016
42
Predictions and presumptive treatment of heparin-induced thrombocytopenia. ( 27147211 )
2016
43
Management of heparin-induced thrombocytopenia. ( 27380556 )
2016
44
Acute oxygenator failure: a new presentation of heparin-induced thrombocytopenia in a patient undergoing venovenous extracorporeal membrane oxygenation support. ( 27986695 )
2016
45
Inappropriate documentation of heparin allergy in the medical record because of misdiagnosis of heparin-induced thrombocytopenia: frequency and consequences. ( 28012249 )
2016
46
How we manage patients with heparin induced thrombocytopenia. ( 27097741 )
2016
47
Indiscriminate Testing for Heparin-Induced Thrombocytopenia: A Teachable Moment. ( 27043083 )
2016
48
Role of monocytes and endothelial cells in heparin-induced thrombocytopenia. ( 27487857 )
2016
49
Persistent heparin-induced thrombocytopenia: danaparoid cross-reactivity or delayed-onset heparin-induced thrombocytopenia? A case report. ( 27100305 )
2016
50
TCT-216 Bivalrudin vs. Argatroban for treatment of Heparin-induced Thrombocytopenia: A Meta-analysis. ( 27970391 )
2016

Variations for Heparin-Induced Thrombocytopenia

Expression for Heparin-Induced Thrombocytopenia

Search GEO for disease gene expression data for Heparin-Induced Thrombocytopenia.

Pathways for Heparin-Induced Thrombocytopenia

GO Terms for Heparin-Induced Thrombocytopenia

Cellular components related to Heparin-Induced Thrombocytopenia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.46 CD40LG F3 SELP SERPINC1
2 plasma membrane GO:0005886 9.43 CD40LG F10 F3 FCGR2A SELP SERPINC1
3 intrinsic component of external side of plasma membrane GO:0031233 8.62 F10 F3

Biological processes related to Heparin-Induced Thrombocytopenia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 9.33 F10 F3 SERPINC1
2 positive regulation of protein kinase B signaling GO:0051897 9.32 F10 F3
3 leukocyte cell-cell adhesion GO:0007159 9.26 CD40LG SELP
4 blood coagulation, extrinsic pathway GO:0007598 8.96 F10 F3
5 hemostasis GO:0007599 8.8 F10 F3 SERPINC1

Molecular functions related to Heparin-Induced Thrombocytopenia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 8.96 F3 SERPINC1
2 phospholipid binding GO:0005543 8.62 F10 F3

Sources for Heparin-Induced Thrombocytopenia

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