MCID: HPR003
MIFTS: 46

Heparin-Induced Thrombocytopenia malady

Rare diseases, Blood diseases categories

Aliases & Classifications for Heparin-Induced Thrombocytopenia

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Sources:
41NIH Rare Diseases, 47Orphanet, 60UMLS, 26ICD10 via Orphanet, 61UMLS via Orphanet
See all sources

Heparin-Induced Thrombocytopenia, Aliases & Descriptions:

Name: Heparin-Induced Thrombocytopenia 41 47 60
Heparin-Induced Thrombocytopenia Type 2 41 47
Heparin-Associated Thrombocytopenia 41 47
 
Hat 41 47
Hit 41 47


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Blood diseases


Characteristics (Orphanet epidemiological data):

47
heparin-induced thrombocytopenia:
Inheritance: Not applicable; Age of onset: All ages


External Ids:

Orphanet47 3325
ICD10 via Orphanet26 D69.5
UMLS via Orphanet61 C0272285

Summaries for Heparin-Induced Thrombocytopenia

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NIH Rare Diseases:41 Heparin-induced thrombocytopenia (hit) is an adverse reaction to the drug heparin resulting in an abnormally low amount of platelets (thrombocytopenia). hit is usually an immune response which typically occurs 4-10 days after exposure to heparin; it can lead to serious complications and be life-threatening. this condition occurs in up to 5% of those who are exposed to heparin. characteristic signs of hit are a drop in platelet count of  greater than 50% and/or the formation of new blood clots during heparin therapy.  the first step of treatment is to discontinue and avoid all heparin products immediately. often, affected individuals require another medicine to prevent blood clotting (anticoagulants). last updated: 5/3/2012

MalaCards based summary: Heparin-Induced Thrombocytopenia, also known as heparin-induced thrombocytopenia type 2, is related to thrombocytopenia and sagittal sinus thrombosis. An important gene associated with Heparin-Induced Thrombocytopenia is F3 (coagulation factor III (thromboplastin, tissue factor)), and among its related pathways are Collagen biosynthesis and modifying enzymes and Complement and coagulation cascades. The compounds celite and roxifiban have been mentioned in the context of this disorder. Affiliated tissues include testes, heart and liver, and related mouse phenotypes are cardiovascular system and hematopoietic system.

Wikipedia:63 Heparin-induced thrombocytopenia (HIT) is the development of thrombocytopenia (a low platelet count),... more...

Related Diseases for Heparin-Induced Thrombocytopenia

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Diseases related to Heparin-Induced Thrombocytopenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 101)
idRelated DiseaseScoreTop Affiliating Genes
1thrombocytopenia31.2CD40LG, F3, SERPINC1, FCGR2A, F10, GP1BA
2sagittal sinus thrombosis31.1SERPINC1
3pulmonary embolism31.0F3, SERPINC1, F10
4coronary thrombosis31.0SERPINC1, F3
5endocarditis30.9F10
6purpura30.8SERPINC1
7acute myocardial infarction30.6F10, SERPINC1, F3
8antiphospholipid syndrome30.4CD40LG, F3, SERPINC1, F10
9myocardial infarction30.4GP1BA, F10, SERPINC1, F3
10connective tissue disease30.3CD40LG, F3
11liver disease30.3F3, SERPINC1
12lupus erythematosus30.3SERPINC1, F3, CD40LG
13disseminated intravascular coagulation30.3F10, SERPINC1, F3
14systemic lupus erythematosus30.0CD40LG, F3, FCGR2A, F10
15thrombocytosis29.9GP1BA, F10, SERPINC1, F3
16cerebritis10.7
17budd-chiari syndrome10.6
18paroxysmal nocturnal hemoglobinuria10.5
19hemoglobinuria10.5
20aneurysm10.5
21carotid artery thrombosis10.5F3
22polycythemia vera10.4
23obesity10.4
24hepatitis10.4
25myocarditis10.4
26polycythemia10.4
27catastrophic antiphospholipid syndrome10.4
28giant cell myocarditis10.4
29dysfibrinogenemia10.4SERPINC1
30burns10.3
31transient global amnesia10.3
32essential thrombocythemia10.3
33acute adrenal insufficiency10.3
34viral hepatitis10.3F10
35hemorrhagic fever10.3CD40LG
36scrub typhus10.2CD40LG
37factor x deficiency10.2F3, F10
38hemarthrosis10.2F3, F10
39von willebrand's disease10.2F3, GP1BA
40afibrinogenemia10.2F3, F10
41ulcerative colitis10.2
42mitral valve stenosis10.2
43marantic endocarditis10.2
44pituitary apoplexy10.2
45thrombotic thrombocytopenic purpura10.2
46splenic infarction10.2
47abdominal aortic aneurysm10.2
48hepatic vein thrombosis10.2
49acquired thrombocytopenia10.2
50qualitative platelet defect10.2

Graphical network of the top 20 diseases related to Heparin-Induced Thrombocytopenia:



Diseases related to heparin-induced thrombocytopenia

Symptoms for Heparin-Induced Thrombocytopenia

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Drugs & Therapeutics for Heparin-Induced Thrombocytopenia

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Drug clinical trials:

Search ClinicalTrials for Heparin-Induced Thrombocytopenia

Search NIH Clinical Center for Heparin-Induced Thrombocytopenia

Genetic Tests for Heparin-Induced Thrombocytopenia

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Anatomical Context for Heparin-Induced Thrombocytopenia

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MalaCards organs/tissues related to Heparin-Induced Thrombocytopenia:

31
Testes, Heart, Liver, Skin, Monocytes, Whole blood, Lung, Pituitary, Colon, T cells, B cells, Endothelial

Animal Models for Heparin-Induced Thrombocytopenia or affiliated genes

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MGI Mouse Phenotypes related to Heparin-Induced Thrombocytopenia:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.1CD40LG, F3, SERPINC1, F10
2MP:00053977.6CD40LG, F3, SERPINC1, FCGR2A, GP1BA
3MP:00053767.5GP1BA, F10, SERPINC1, F3, CD40LG
4MP:00107687.3F10, FCGR2A, SERPINC1, F3, CD40LG

Publications for Heparin-Induced Thrombocytopenia

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Articles related to Heparin-Induced Thrombocytopenia:

(show top 50)    (show all 700)
idTitleAuthorsYear
1
Heparin-induced thrombocytopenia. (25751293)
2015
2
Perioperative use of iloprost in cardiac surgery patients diagnosed with heparin-induced thrombocytopenia (HIT) reactive antibodies or with true HIT (HIT reactive antibodies plus thrombocytopenia): An eleven year experience. (25808486)
2015
3
Transfemoral Transcatheter Aortic Valve Replacement in a Patient With Heparin-Induced Thrombocytopenia: Intraoperative Anticoagulation Management With Bivalirudin (Angiomax). (25604599)
2015
4
Heparin-induced thrombocytopenia associated with thrombotic microangiopathy. (23715106)
2013
5
Argatroban in heparin-induced thrombocytopenia: rationale for use and place in therapy. (24179672)
2013
6
The frequency of heparin-induced thrombocytopenia in Taiwanese patients undergoing cardiopulmonary bypass surgery. (24331583)
2013
7
Clinical and Laboratory Diagnosis of Heparin-Induced Thrombocytopenia: An Integrated Approach. (24363239)
2013
8
Heparin-induced thrombocytopenia: is it a graft-threatening complication? (23293891)
2013
9
Hemodialysis-associated acute systemic reactions and heparin-induced thrombocytopenia. (22127211)
2012
10
Treatment and prevention of heparin-induced thrombocytopenia: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. (22315270)
2012
11
Left ventricular assist device, heparin-induced thrombocytopenia, and thrombus formation. (22186463)
2012
12
Treatment outcomes of heparin-induced thrombocytopenia in subarachnoid hemorrhage patients: a 4-year, retrospective single-center review. (22692920)
2012
13
Pituitary metastasis presenting as ischemic pituitary apoplexy following heparin-induced thrombocytopenia. (23129546)
2012
14
Interleukin-10 promoter microsatellite polymorphisms influence the immune response to heparin and the risk of heparin-induced thrombocytopenia. (22239992)
2012
15
What are the options for anticoagulation needs in dialysis for patients with heparin-induced thrombocytopenia? (21851394)
2011
16
A clinical-laboratory algorithm incorporating optical density value to predict heparin-induced thrombocytopenia. (21264443)
2011
17
Heparin-induced thrombocytopenia and the utility of the 4Ts score in the Intensive Care Unit. (21255001)
2011
18
Evaluation of a standardized protocol using lepirudin or argatroban for heparin-induced thrombocytopenia. (21902659)
2011
19
Use of fondaparinux in a pregnant woman with pulmonary embolism and heparin-induced thrombocytopenia. (21525816)
2011
20
High rates of venous thromboembolism prophylaxis did not increase the incidence of heparin-induced thrombocytopenia. (21500716)
2011
21
Novel use of plasmapheresis in a patient with heparin-induced thrombocytopenia requiring urgent insertion of a left ventricular assist device under cardiopulmonary bypass. (20723718)
2010
22
False-positive tests for heparin-induced thrombocytopenia in patients with antiphospholipid syndrome and systemic lupus erythematosus: a rebuttal. (20345710)
2010
23
Argatroban and renal replacement therapy in a morbidly obese patient with heparin-induced thrombocytopenia: a case report. (20116834)
2010
24
Heparin-induced thrombocytopenia in surgical patients. (20103065)
2010
25
Heparin-induced thrombocytopenia and warfarin-induced skin necrosis: case report. (21308322)
2010
26
Pulmonary embolectomy in heparin-induced thrombocytopenia and thrombosis? Safety of heparin use. (20962169)
2010
27
Treatment of heparin-induced thrombocytopenia after cardiac surgery: preliminary experience with fondaparinux. (19660283)
2010
28
Argatroban in the management of heparin-induced thrombocytopenia. (20859550)
2010
29
Heparin-induced thrombocytopenia type II with thrombosis in an intensive care patient: therapy management using the direct thrombin inhibitor argatroban]. (19795099)
2009
30
Dosing lepirudin in patients with heparin-induced thrombocytopenia and normal or impaired renal function: a single-center experience with 68 patients. (19059879)
2009
31
Clinical experience with argatroban for heparin-induced thrombocytopenia in a large teaching hospital. (22478907)
2009
32
Reducing harm associated with anticoagulation: practical considerations of argatroban therapy in heparin-induced thrombocytopenia. (19338378)
2009
33
A clinical-laboratory approach contributing to a rapid and reliable diagnosis of heparin-induced thrombocytopenia: An update. (19632705)
2009
34
Cerebral infarction associated with heparin-induced thrombocytopenia in a patient with encephalitis. (19122360)
2009
35
Serologic results in >1000 patients with suspected heparin-induced thrombocytopenia. (17895512)
2008
36
Warfarin-induced skin necrosis in a patient with heparin-induced thrombocytopenia: two diseases or one? (19018128)
2008
37
Risk of heparin-induced thrombocytopenia in patients receiving thromboprophylaxis. (21083008)
2008
38
Heparin-induced thrombocytopenia: diagnosis and management. (18544310)
2008
39
Spontaneous superior sagittal sinus thrombosis secondary to type II heparin-induced thrombocytopenia presenting as an acute subarachnoid hemorrhage. (17582771)
2007
40
Anticoagulation options for patients with heparin-induced thrombocytopenia requiring renal support in the intensive care unit. (17464135)
2007
41
Heparin-induced thrombocytopenia in a uremic patient requiring hemodialysis: an alternative treatment and reexposure to heparin. (17456628)
2007
42
Incidence and clinical significance of anti-PF4/heparin antibodies of the IgG, IgM, and IgA class in 755 consecutive patient samples referred for diagnostic testing for heparin-induced thrombocytopenia. (16466367)
2006
43
Successful renal transplantation in a patient with heterozygous prothrombin gene, factor V Leiden mutation and heparin-induced thrombocytopenia using r-hirudin as anticoagulant. (16499600)
2006
44
Prevalence of heparin-induced thrombocytopenia in patients undergoing cardiac catheterization. (16875910)
2006
45
Use of ecarin clotting time in whole blood for monitoring recombinant hirudine treatment during cardiopulmonary bypass in patients with heparin-induced thrombocytopenia]. (15771978)
2005
46
Lepirudin for prophylaxis of thrombosis in patients with acute isolated heparin-induced thrombocytopenia: an analysis of 3 prospective studies. (15280202)
2004
47
Argatroban for prevention and treatment of thromboembolism in heparin-induced thrombocytopenia. (11302409)
2001
48
Factor V Leiden and thrombotic complications in heparin-induced thrombocytopenia. (9459322)
1998
49
Characterization of the humoral immune response in heparin-induced thrombocytopenia. (9067497)
1997
50
Heparin-induced thrombocytopenia and thrombosis. (9372019)
1995

Variations for Heparin-Induced Thrombocytopenia

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Expression for genes affiliated with Heparin-Induced Thrombocytopenia

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Search GEO for disease gene expression data for Heparin-Induced Thrombocytopenia.

Pathways for genes affiliated with Heparin-Induced Thrombocytopenia

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Pathways related to Heparin-Induced Thrombocytopenia according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
8.9F3, SERPINC1, F10
2
Show member pathways
Complement Activation, Classical Pathway36
Complement and Coagulation Cascades36
8.9F10, SERPINC1, F3
3
Show member pathways
8.4F3, SERPINC1, F10, GP1BA
4
Show member pathways
8.4GP1BA, F10, SERPINC1, F3

Compounds for genes affiliated with Heparin-Induced Thrombocytopenia

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Compounds related to Heparin-Induced Thrombocytopenia according to GeneCards Suite gene sharing:

(show top 50)    (show all 90)
idCompoundScoreTop Affiliating Genes
1celite439.7SERPINC1, F3
2roxifiban439.7F10, F3
3heparin pentasaccharide439.6F10, SERPINC1
4certoparin439.5SERPINC1, F3
5reviparin439.4SERPINC1, F3
6dabigatran49 4310.4F10, SERPINC1, F3
7efegatran439.4F10, SERPINC1, F3
8ecarin439.3F3, SERPINC1, F10
9inogatran439.3SERPINC1, F3
10nadroparin43 1210.3F10, SERPINC1, F3
11spectrozyme439.3F10, SERPINC1, F3
12danaparoid439.3F3, SERPINC1, F10
13rivaroxaban43 1210.3F10, SERPINC1, F3
14tinzaparin43 1210.3F10, SERPINC1, F3
15ximelagatran43 1210.3F10, F3, SERPINC1
16organon439.3F3, SERPINC1, F10
17heparinoids439.3F3, SERPINC1, F10
18fondaparinux439.3F10, SERPINC1, F3
19bivalirudin43 1210.3F10, SERPINC1, F3
20argatroban43 1210.3F3, SERPINC1, F10
21protamine sulfate439.3F10, SERPINC1, F3
22ristocetin439.3F3, SERPINC1, GP1BA
23desirudin439.2F10, F3
24desmopressin43 59 28 1212.2GP1BA, SERPINC1, F3
25coumarin43 2 49 2412.2F10, SERPINC1, F3
26protamine439.1F3, SERPINC1, F10
27dermatan sulfate439.1F10, SERPINC1, F3
28warfarin43 49 24 1212.1F3, SERPINC1, F10
29kininogen439.1GP1BA, SERPINC1, F3
30cardiolipin43 1210.0CD40LG, F3, F10
31silicone438.8CD40LG, SERPINC1, F10
32prostacyclin438.8GP1BA, FCGR2A, SERPINC1, F3
33aprotinin43 129.8F3, SERPINC1, F10, GP1BA
34ppack438.5F10, SERPINC1, F3, CD40LG
35epinephrine43 24 1210.5GP1BA, FCGR2A, F3, CD40LG
36tirofiban43 129.5CD40LG, F3, SERPINC1, F10
37clopidogrel43 49 24 1211.5F10, SERPINC1, F3, CD40LG
38fluorescein43 129.5F10, SERPINC1, F3, CD40LG
39dextran sulfate438.5F10, SERPINC1, F3, CD40LG
40phosphatidylserine43 28 1210.5GP1BA, F10, F3, CD40LG
41polyethylene glycol438.5CD40LG, SERPINC1, F10
42polysaccharide438.1F10, FCGR2A, SERPINC1, F3, CD40LG
43hirudin438.0GP1BA, F10, SERPINC1, F3, CD40LG
44aspirin43 49 28 2411.0GP1BA, F10, SERPINC1, F3, CD40LG
45fibrinogen438.0GP1BA, F10, SERPINC1, F3, CD40LG
46alanine437.9GP1BA, F10, SERPINC1, F3, CD40LG
47abciximab43 128.6CD40LG, F3, SERPINC1, FCGR2A, F10, GP1BA
48heparin43 28 24 1210.6GP1BA, F10, FCGR2A, SERPINC1, F3, CD40LG
49adp43 28 249.5GP1BA, F10, FCGR2A, SERPINC1, F3, CD40LG
50serine437.5GP1BA, F10, FCGR2A, SERPINC1, F3, CD40LG

GO Terms for genes affiliated with Heparin-Induced Thrombocytopenia

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Cellular components related to Heparin-Induced Thrombocytopenia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1intrinsic component of external side of plasma membraneGO:00312339.2F3, F10
2plasma membraneGO:00058867.1CD40LG, F3, SERPINC1, FCGR2A, F10, GP1BA

Biological processes related to Heparin-Induced Thrombocytopenia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1blood coagulation, extrinsic pathwayGO:00075989.5F3, F10
2positive regulation of cell migrationGO:00303359.5F3, F10
3blood coagulation, intrinsic pathwayGO:00075979.3GP1BA, F10
4positive regulation of protein kinase B signalingGO:00518979.2F3, F10
5blood coagulationGO:00075968.5F3, SERPINC1, F10, GP1BA

Molecular functions related to Heparin-Induced Thrombocytopenia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1phospholipid bindingGO:00055439.5F3, F10
2protease bindingGO:00020209.1F3, SERPINC1

Products for genes affiliated with Heparin-Induced Thrombocytopenia

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Sources for Heparin-Induced Thrombocytopenia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet