MCID: HPR003
MIFTS: 44

Heparin-Induced Thrombocytopenia

Categories: Rare diseases, Blood diseases

Aliases & Classifications for Heparin-Induced Thrombocytopenia

MalaCards integrated aliases for Heparin-Induced Thrombocytopenia:

Name: Heparin-Induced Thrombocytopenia 50 56 69
Hit 50 56
Heparin-Induced Thrombocytopenia Type 2 56
Heparin-Associated Thrombocytopenia 56
Hat 56

Characteristics:

Orphanet epidemiological data:

56
heparin-induced thrombocytopenia
Inheritance: Not applicable; Age of onset: All ages;

Classifications:



External Ids:

Orphanet 56 ORPHA3325
UMLS via Orphanet 70 C0272285
ICD10 via Orphanet 34 D69.5

Summaries for Heparin-Induced Thrombocytopenia

NIH Rare Diseases : 50 heparin-induced thrombocytopenia (hit) is an adverse reaction to the drug heparin resulting in an abnormally low amount of platelets (thrombocytopenia). hit is usually an immune response which typically occurs 4-10 days after exposure to heparin; it can lead to serious complications and be life-threatening. this condition occurs in up to 5% of those who are exposed to heparin. characteristic signs of hit are a drop in platelet count of  greater than 50% and/or the formation of new blood clots during heparin therapy.  the first step of treatment is to discontinue and avoid all heparin products immediately. often, affected individuals require another medicine to prevent blood clotting (anticoagulants). last updated: 5/3/2012

MalaCards based summary : Heparin-Induced Thrombocytopenia, also known as hit, is related to pulmonary embolism and budd-chiari syndrome. An important gene associated with Heparin-Induced Thrombocytopenia is F3 (Coagulation Factor III, Tissue Factor), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Certoparin and Dalteparin have been mentioned in the context of this disorder. Affiliated tissues include testes, liver and heart, and related phenotypes are cardiovascular system and hematopoietic system

Wikipedia : 72 Heparin-induced thrombocytopenia (HIT) is the development of thrombocytopenia (a low platelet count),... more...

Related Diseases for Heparin-Induced Thrombocytopenia

Diseases related to Heparin-Induced Thrombocytopenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 142)
id Related Disease Score Top Affiliating Genes
1 pulmonary embolism 30.4 CD40LG FCGR2A
2 budd-chiari syndrome 30.3 F3 SERPINC1
3 sagittal sinus thrombosis 30.3 F3 SERPINC1
4 essential thrombocythemia 30.2 F3 SERPINC1
5 pericarditis 29.2 F3 SELP SERPINC1
6 systemic lupus erythematosus 29.0 CD40LG F3 FCGR2A
7 myocardial infarction 27.8 CD40LG F10 F3 SELP SERPINC1
8 myeloproliferative neoplasm 27.4 CD40LG F10 F3 SELP SERPINC1
9 thrombocytopenia 11.2
10 thrombosis 10.7
11 cavernous lymphangioma 10.4 CD40LG F3
12 chronic inflammatory demyelinating polyneuritis 10.4 CD40LG F3
13 mental retardation, autosomal recessive 35 10.4 CD40LG F3
14 rheumatic heart disease 10.4 CD40LG F3
15 megaloblastic anemia 10.4 CD40LG F3
16 mental depression 10.3 CD40LG SELP
17 ovarian endometrioid cystadenoma 10.3 CD40LG F3
18 retromolar area cancer 10.3 CD40LG SELP
19 thumb stiff brachydactyly mental retardation 10.3 F3 SELP
20 pyridoxine deficiency anemia 10.3 F3 SERPINC1
21 testicular gonadoblastoma 10.3 F3 SERPINC1
22 rectum neuroendocrine neoplasm 10.3 F3 SERPINC1
23 midline cystocele 10.3 F3 SERPINC1
24 moderately severe hemophilia b 10.3 F3 FCGR2A
25 tuberculoid leprosy 10.3 CD40LG SELP
26 chronic diarrhea due to guanylate cyclase 2c overactivity 10.3 F3 SERPINC1
27 lymphatic system cancer 10.3 F3 SERPINC1
28 thrombomodulin anomalies, familial 10.3 F3 SELP
29 lethal congenital contracture syndrome 10.3 F3 SERPINC1
30 femoral neuropathy 10.3 F3 SERPINC1
31 diphyllobothriasis 10.3 CD40LG SERPINC1
32 spinal cord lipoma 10.3 F3 SERPINC1
33 cerebritis 10.2
34 angioedema, hereditary, type iii 10.2 F3 SERPINC1
35 congenital syphilis 10.2 F3 SERPINC1
36 rocky mountain spotted fever 10.2 CD40LG SERPINC1
37 monocular exotropia 10.2 F3 SERPINC1
38 antiphospholipid syndrome 10.2
39 coronary stenosis 10.2 F3 SERPINC1
40 osteogenesis imperfecta, type vii 10.2 CD40LG SELP
41 capillary hemangioma 10.2 F3 SERPINC1
42 blepharoconjunctivitis 10.2 F3 SERPINC1
43 aryepiglottic fold cancer 10.2 F3 SERPINC1
44 stickler sydrome, type i, nonsyndromic ocular 10.2 CD40LG SERPINC1
45 haemophilus meningitis 10.2 F3 SERPINC1
46 atrophic nonflaccid tympanic membrane 10.2 F3 SELP
47 cryptosporidiosis 10.1 SELP SERPINC1
48 cervix squamous papilloma 10.1 F3 SERPINC1
49 american histoplasmosis 10.1 SELP SERPINC1
50 hemolytic-uremic syndrome 10.1 F3 SERPINC1

Graphical network of the top 20 diseases related to Heparin-Induced Thrombocytopenia:



Diseases related to Heparin-Induced Thrombocytopenia

Symptoms & Phenotypes for Heparin-Induced Thrombocytopenia

MGI Mouse Phenotypes related to Heparin-Induced Thrombocytopenia:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.55 SERPINC1 CD40LG F10 F3 SELP
2 hematopoietic system MP:0005397 9.35 SERPINC1 CD40LG F3 FCGR2A SELP
3 mortality/aging MP:0010768 9.1 SERPINC1 CD40LG F10 F3 FCGR2A SELP

Drugs & Therapeutics for Heparin-Induced Thrombocytopenia

Drugs for Heparin-Induced Thrombocytopenia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 62)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Certoparin Approved Phase 4
2
Dalteparin Approved Phase 4,Phase 3,Phase 2,Phase 1 9005-49-6
3
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 9005-49-6 772 46507594
4
Bivalirudin Approved, Investigational Phase 4,Phase 3 128270-60-0 16129704
5
Argatroban Approved, Investigational Phase 4,Phase 3,Phase 2 74863-84-6 152951
6 Nadroparin Approved Phase 4 9041-08-1
7
Desirudin Approved Phase 4,Phase 2,Phase 3 120993-53-5
8
Thrombin Approved Phase 4,Phase 3,Phase 2
9
Lepirudin Approved Phase 4 120993-53-5, 138068-37-8 16132441
10
Warfarin Approved Phase 4,Phase 3,Phase 2 81-81-2 6691 54678486
11 Fondaparinux Investigational Phase 4,Phase 3,Phase 2,Phase 1 104993-28-4
12 Antibodies Phase 4,Phase 3,Phase 1
13 Anticoagulants Phase 4,Phase 3,Phase 2,Phase 1
14 calcium heparin Phase 4,Phase 3,Phase 2,Phase 1
15 Calcium, Dietary Phase 4,Phase 3,Phase 2,Phase 1
16 Fibrinolytic Agents Phase 4,Phase 3,Phase 2,Phase 1
17 Heparin, Low-Molecular-Weight Phase 4,Phase 3,Phase 2,Phase 1
18 Immunoglobulins Phase 4,Phase 3,Phase 1
19 Antithrombin III Phase 4,Phase 3,Phase 2
20 Antithrombins Phase 4,Phase 3,Phase 2
21 Hirudins Phase 4,Phase 3,Phase 2
22 HIV Protease Inhibitors Phase 4,Phase 3,Phase 2
23
protease inhibitors Phase 4,Phase 3,Phase 2
24 Serine Proteinase Inhibitors Phase 4,Phase 3,Phase 2
25 Thromboplastin Phase 4,Phase 3
26 PENTA Phase 4,Phase 3,Phase 2,Phase 1
27 Platelet Aggregation Inhibitors Phase 4,Phase 3,Phase 2
28 Liver Extracts Phase 4
29 Platelet Factor 4 Phase 4
30
Bilirubin Phase 4 635-65-4 5280352
31 Coagulants Phase 4
32 serine Nutraceutical Phase 4,Phase 3,Phase 2
33
Benzocaine Approved Phase 3 1994-09-7, 94-09-7 2337
34
Rivaroxaban Approved Phase 3,Phase 2 366789-02-8
35
Ethanol Approved Phase 3 64-17-5 702
36 tannic acid Approved, Nutraceutical Phase 3
37 Factor Xa Inhibitors Phase 3,Phase 2
38 Anti-Infective Agents Phase 3
39 Anti-Infective Agents, Local Phase 3
40 Central Nervous System Depressants Phase 3
41 Pharmaceutical Solutions Phase 3
42
Creatine Nutraceutical Phase 2, Phase 3 57-00-1 586
43 Kava Nutraceutical Phase 2, Phase 3 9000-38-8
44 Citrate Nutraceutical Phase 3
45
Citric Acid Nutraceutical, Vet_approved Phase 3 77-92-9 311
46
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
47
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
48 Albumin-Bound Paclitaxel Phase 2
49 Antimitotic Agents Phase 2
50 Antineoplastic Agents, Phytogenic Phase 2

Interventional clinical trials:

(show top 50) (show all 61)

id Name Status NCT ID Phase Drugs
1 The HIT-TRAP Trial Unknown status NCT00196417 Phase 4 Standard heparin (UFH) versus certoparin (LMWH)
2 Efficacy and Safety of Heparin-coated Surface-treated Polyacrylonitrile Membrane Hemofilter in Critical Ill CRRT Patients Unknown status NCT02355873 Phase 4
3 Impact of Heparin on the Need for Mechanical Ventilation in Neonates Unknown status NCT00196469 Phase 4 heparin
4 Bivalirudin PCI Registry in Heparin Induced Thrombocytopenia/Heparin Induced Thrombocytopenia and Thrombosis Syndrome (HIT/HITTS) Patients Completed NCT00759083 Phase 4 bivalirudin
5 Evaluation of Argatroban Injection in Pediatric Patients Requiring Anticoagulant Alternatives to Heparin Completed NCT00039858 Phase 4 Argatroban
6 Venous Thromboembolic Prophylaxis After Trauma: Three Times a Day Unfractionated Heparin Versus Twice a Day Enoxaparin Completed NCT01729559 Phase 4 5000 Units unfractionated Heparin Q 8 hr;30mg enoxaparin Q12 hr
7 Nadroparin for the Initial Treatment of Pulmonary Thromboembolism Completed NCT00796692 Phase 4 Nadroparin;Unfractionated heparin(UFH)
8 Study to Evaluate the Mortality Reduction of Enoxaparin in Hospitalized Acutely Ill Medical Receiving Enoxaparin Completed NCT00622648 Phase 4 Enoxaparin;Placebo
9 EXCLAIM:Extended Prophylaxis for Venous ThromboEmbolism (VTE) in Acutely Ill Medical Patients With Prolonged Immobilization Completed NCT00077753 Phase 4 enoxaparin sodium
10 Safety Study of Desirudin, an Anticoagulant for the Prophylaxis of Thrombosis Completed NCT00913133 Phase 4 Desirudin
11 A Comparative Sudy Comparing Argatroban® IV vs Desirudin SC for Suspected HIT With or Without Thrombosis Syndrome Terminated NCT00787332 Phase 4 Desirudin or Argatroban®
12 Argatroban Versus Lepirudin in Critically Ill Patients Terminated NCT00798525 Phase 4 Argatroban;Lepirudin
13 Significance of Antibodies to Heparin/Platelet Factor 4 Complex in Vein Graft Patency and Potential Role of Argatroban for Prevention of Vein Graft Occlusion Terminated NCT01246011 Phase 4 Argatroban and warfarin
14 Fondaparinux in Patients With Acute Heparin-Induced Thrombocytopenia (HIT) Withdrawn NCT00603824 Phase 4 fondaparinux;argatroban or lepirudin
15 Angiomax in Patients With HIT/HITTS Type II Undergoing Off-Pump Coronary Artery Bypass Grafting (CABG) (CHOOSE) Unknown status NCT00073580 Phase 3 Angiomax (bivalirudin) anticoagulant
16 Fondaparinux to Prevent Thrombotic Complications and Graft Failure in Patients Undergoing Coronary Artery Bypass Graft Surgery: The Fonda CABG Study Unknown status NCT00474591 Phase 3 Fondaparinux
17 Efficacy and Safety Study of Argatroban to Treat Heparin-Induced Thrombocytopenia Completed NCT00198588 Phase 3 argatroban
18 Anticoagulant Therapy With Bivalirudin in the Performance of Percutaneous Coronary Intervention in Patients With Heparin-Induced Thrombocytopenia (AT BAT, First Inning) Completed NCT00043940 Phase 3 bivalirudin
19 Angiomax in Patients With HIT/HITTS Type II Undergoing CPB Completed NCT00079508 Phase 3 Angiomax (bivalirudin)
20 PROphylaxis for ThromboEmbolism in Critical Care Trial (PROTECT) Completed NCT00182143 Phase 3 LMWH (Fragmin, dalteparin);Unfractionated Heparin
21 The Use of Fondaparinux in Preventing Thromboembolism in High Risk Trauma Patients Completed NCT00531843 Phase 2, Phase 3 fondaparinux sodium
22 Heparin 100U/L for Prevention of PVC Complications Completed NCT01131754 Phase 3
23 Study Comparing Desirudin With Heparin to Prevent Vein Clots After Heart and Lung Surgery Completed NCT00329433 Phase 2, Phase 3 Desirudin (Iprivask™);Heparin
24 PROSPER: PostpaRtum PrOphylaxiS for PE Randomized Control Trial Pilot Completed NCT01274637 Phase 3 Dalteparin Sodium
25 A Safety and Efficacy Study of BCD-080 Compared to Clexan for Deep Vein Thrombosis Prophylaxis at Orthopedic Surgeries Completed NCT02368314 Phase 3 Sodium Enoxaparine
26 Multi-Center Single Arm Trial to Determine The Effectiveness of Warfarin Therapy Duration For Heparin-Induced Thrombocytopenia (HIT) Recruiting NCT03147638 Phase 3 Warfarin, NOAC
27 Evaluation of the Efficacy of an inTerdialytic "Ethanol 40% v/v - enoxapaRin 1000 U/mL" Lock solutioN to Prevent Tunnelled Catheter Infections in Chronic Hemodialysis Patients Not yet recruiting NCT03083184 Phase 3 Ethanol;enoxaparin
28 Rivaroxaban for Treatment of Patients With Suspected or Confirmed Heparin-Induced Thrombocytopenia Terminated NCT01598168 Phase 3 Rivaroxaban
29 Clinical Management of Argatroban in Patients With Heparin Induced Thrombocytopenia Type II Completed NCT00861692 Phase 2 argatroban
30 ODiXahip - a Phase IIa Dose Escalating Proof of Principle Trial Completed NCT00839826 Phase 2 Rivaroxaban (BAY59-7939);Enoxaparin
31 Addition of Enoxaparin to Neoadjuvant Chemoradiation of Esophageal Cancer Recruiting NCT03254511 Phase 2 Enoxaparin Sodium 40 MG/0.2 ML Subcutaneous Injectable;Chemotherapeutic Combinations
32 Aneurysmal Subarachnoid Hemorrhage Trial RandOmizing Heparin Recruiting NCT02501434 Phase 2 Continuous Low-Dose IV Unfractionated Heparin Infusion
33 Extended Low-Molecular Weight Heparin VTE Prophylaxis in Thoracic Surgery Recruiting NCT02334007 Phase 1, Phase 2 LMWH: Dalteparin
34 Catheter-Related Early Thromboprophylaxis With Enoxaparin (CRETE) Trial Recruiting NCT03003390 Phase 2 Enoxaparin
35 Fondaparinux for the Treatment of Heparin-Induced Thrombocytopenia (HIT) Terminated NCT00673439 Phase 2 fondaparinux;warfarin
36 Heparin-Induced Thrombocytopenia Score Card Study Completed NCT00489437 Phase 1
37 Pilot Dose Finding and Pharmacokinetic Study of Fondaparinux in Children With Thrombosis Completed NCT00412464 Phase 1 Fondaparinux
38 Validating 4Ts for Heparin Induced Thrombocytopenia (HIT) Unknown status NCT00946400
39 A Study on the Prevalence of Heparin-Induced Thrombocytopenia in Cardiovascular Patients Unknown status NCT00198575
40 Generation of Heparin-induced Thrombocytopenia (HIT)-Antibodies Without Prior Heparin Exposure Unknown status NCT01102790
41 Incidence and Nature of Heparin-induced Skin Lesions in Medical Patients Unknown status NCT00510432
42 Need for Antepartum Thromboprophylaxis in Pregnant Women With One Prior Episode of Venous Thromboembolism (VTE) Unknown status NCT01357941
43 Rapid Diagnosis of Heparin-Induced Thrombocytopenia in Surgical Critically Ill Patients Completed NCT02790567
44 Heparin-Induced Thrombocytopenia Registry Completed NCT00456326
45 Heparin-Induced Thrombocytopenia: Development and Validation of a Predictive Clinical Completed NCT00748839
46 Heparin Induced Thrombocytopenia: Pharmacoeconomics Completed NCT00456001
47 Heparin-induced Thrombocytopenia (HIT II) in Liver Transplant Recipients Completed NCT01654848
48 Heparin-Induced Thrombocytopenia - Retrospective Analysis of Data on Incidence and Outcomes Study Completed NCT01178333
49 Retrospective Registry of Patients With Acute Heparin-induced Thrombocytopenia Type II Completed NCT01304238 lepirudin;danaparoid;argatroban;fondaparinux
50 Heparin Antibodies in Intensive Care Unit Patients (HAICU) Completed NCT00283322

Search NIH Clinical Center for Heparin-Induced Thrombocytopenia

Genetic Tests for Heparin-Induced Thrombocytopenia

Anatomical Context for Heparin-Induced Thrombocytopenia

MalaCards organs/tissues related to Heparin-Induced Thrombocytopenia:

39
Testes, Liver, Heart, Skin, Lung, Monocytes, Endothelial

Publications for Heparin-Induced Thrombocytopenia

Articles related to Heparin-Induced Thrombocytopenia:

(show top 50) (show all 817)
id Title Authors Year
1
The Role of Apixaban in the Treatment of Heparin-Induced Thrombocytopenia. ( 28884054 )
2017
2
Hydrophilic Polymer Embolism in the Lung as an Adverse Eventa88- Autopsy Case of Thromboembolisms in Multiple Organs Associated With Heparin-Induced Thrombocytopenia. ( 28626145 )
2017
3
Effectiveness of a Laboratory Gate-Keeping Strategy to Overcome Inappropriate Test Utilization for the Diagnosis of Heparin-Induced Thrombocytopenia. ( 28750423 )
2017
4
Autoimmune heparin-induced thrombocytopenia. ( 28846826 )
2017
5
Extensive Intracardiac and Deep Venous Thromboses in a Young Woman with Heparin-Induced Thrombocytopenia and May-Thurner Syndrome. ( 28465848 )
2017
6
The Clinical Utility of the Heparin Neutralization Assay in the Diagnosis of Heparin-Induced Thrombocytopenia. ( 28774196 )
2017
7
Direct acting oral anticoagulants for the treatment of suspected heparin-induced thrombocytopenia. ( 28672052 )
2017
8
Persistent Heparin-Induced Thrombocytopenia Treated With IVIg. ( 28889885 )
2017
9
Is low serum albumin level a significant predictor for the development of heparin-induced thrombocytopenia-thrombosis? ( 28289828 )
2017
10
Management of refractory bleeding post-cardiopulmonary bypass in an acute heparin-induced thrombocytopenia type II renal failure patient who underwent urgent cardiac surgery with bivalirudin (Angiox(Ar)) anticoagulation. ( 28789610 )
2017
11
Clinical effectiveness of a Bayesian algorithm for the diagnosis and management of heparin-induced thrombocytopenia. ( 28622439 )
2017
12
Treatment of pulmonary embolism with argatroban and ultrasound-assisted catheter-directed thrombolysis with alteplase in a patient with heparin-induced thrombocytopenia. ( 28743779 )
2017
13
Low dose bivalirudin anticoagulation for lung transplantation with extracorporeal membrane oxygenation in a patient with acute heparin-induced thrombocytopenia. ( 28043990 )
2017
14
Laboratory Testing Protocols for Heparin-Induced Thrombocytopenia (HIT) Testing. ( 28804833 )
2017
15
IV Immunoglobulin forA Autoimmune Heparin-Induced Thrombocytopenia. ( 28889872 )
2017
16
Incidence and Outcomes of Heparin-Induced Thrombocytopenia in Patients Undergoing Vascular Surgery. ( 28864160 )
2017
17
Influence of Human Leukocyte Antigen (HLA) Alleles and Killer Cell Immunoglobulin-Like Receptors (KIR) Types on Heparin-Induced Thrombocytopenia (HIT). ( 28688202 )
2017
18
Apixaban for treatment of confirmed heparin-induced thrombocytopenia: a case report and review of literature. ( 28725494 )
2017
19
Activated platelet-derived and leukocyte-derived circulating microparticles and the risk of thrombosis in heparin-induced thrombocytopenia: A role for pf4-bearing microparticles? ( 28052584 )
2017
20
5B9, a monoclonal antiplatelet factor 4/heparin IgG with a human Fc fragment that mimics heparin-induced thrombocytopenia antibodies. ( 28771917 )
2017
21
Performance of 4T score and heparin-platelet factor 4 antibody in the diagnosis of heparin-induced thrombocytopenia (HIT) in cancer. ( 28677022 )
2017
22
Can rivaroxaban be a drug of choice for treating heparin-induced thrombocytopenia in a patient with pulmonary thromboembolism? ( 28680014 )
2017
23
Heparin-Induced Thrombocytopenia and Vascular Surgery. ( 28807578 )
2017
24
Argatroban for Heparin-Induced Thrombocytopenia during Venovenous Extracorporeal Membrane Oxygenation with Continuous Venovenous Hemofiltration. ( 28638161 )
2017
25
Successful Anticoagulation Using Argatroban During Transcatheter Aortic Valve Implantation in a Patient With Heparin-Induced Thrombocytopenia. ( 27513970 )
2016
26
Heparin-induced thrombocytopenia: research and clinical updates. ( 27913490 )
2016
27
Left Main Artery Thrombus Complicating Heart Transplantation in a Patient With Heparin-Induced Thrombocytopenia. ( 27431594 )
2016
28
Rivaroxaban in treatment refractory heparin-induced thrombocytopenia. ( 27520997 )
2016
29
Role of monocytes and endothelial cells in heparin-induced thrombocytopenia. ( 27487857 )
2016
30
TCT-216 Bivalrudin vs. Argatroban for treatment of Heparin-induced Thrombocytopenia: A Meta-analysis. ( 27970391 )
2016
31
Heparin-induced multi-electrode aggregometry method for heparin-induced thrombocytopenia testing: communication from the SSC of the ISTH. ( 27864862 )
2016
32
Acute apixaban treatment of heparin-induced thrombocytopenia. ( 27844303 )
2016
33
Utilization of 4T score to determine the pretest probability of heparin-induced thrombocytopenia in a community hospital in upstate New York. ( 27609736 )
2016
34
Acute oxygenator failure: a new presentation of heparin-induced thrombocytopenia in a patient undergoing venovenous extracorporeal membrane oxygenation support. ( 27986695 )
2016
35
Predictions and presumptive treatment of heparin-induced thrombocytopenia. ( 27147210 )
2016
36
Platelet Activation Testing for Heparin-Induced Thrombocytopenia Antibodies: A Problem That Needs Fixing? ( 27613972 )
2016
37
Cost-effectiveness of anticoagulants for suspected heparin-induced thrombocytopenia in the United States. ( 27793877 )
2016
38
Heparin-induced thrombocytopenia in solid organ transplant recipients: The current scientific knowledge. ( 27011914 )
2016
39
Increased prevalence of heparin-induced thrombocytopenia in patients with Budd-Chiari syndrome: a retrospective analysis. ( 27015137 )
2016
40
Novel oral anticoagulants for heparin-induced thrombocytopenia. ( 27102287 )
2016
41
Transplantation in a patient on extracorporeal membrane oxygenation with infective endocarditis, pericarditis and heparin-induced thrombocytopenia. ( 28040771 )
2016
42
Bivalirudin Anticoagulation for a Pediatric Patient with Heparin-Induced Thrombocytopenia and Thrombosis Requiring Cardiopulmonary Bypass for Ventricular Assist Device Placement. ( 27134308 )
2016
43
Rapid and durable response to intravenous immunoglobulin in delayed heparin-induced thrombocytopenia: a case report. ( 27943368 )
2016
44
Screening frequency, incidence and pattern of heparin-induced thrombocytopenia syndrome at a large tertiary institution. ( 27106479 )
2016
45
Non-vitamin K antagonist oral anticoagulants for heparin-induced thrombocytopenia. A systematic review of 54 reported cases. ( 27075620 )
2016
46
Evaluation of a flow cytometric assay for the confirmation of heparin-induced thrombocytopenia. ( 26991642 )
2016
47
Clinical and laboratory tests for the diagnosis of heparin-induced thrombocytopenia. ( 27604316 )
2016
48
A Case of Heparin-Induced Thrombocytopenia Type 2 after Repair of Juxtarenal Abdominal Aortic Aneurysm. ( 28031678 )
2016
49
Spontaneous heparin-induced thrombocytopenia (HIT) syndrome: HIT without any heparin exposure. ( 27795522 )
2016
50
Successful intraprocedural anticoagulation with bivalirudin during pulmonary vein isolation in a patient with known heparin-induced thrombocytopenia type II. ( 27092199 )
2016

Variations for Heparin-Induced Thrombocytopenia

Expression for Heparin-Induced Thrombocytopenia

Search GEO for disease gene expression data for Heparin-Induced Thrombocytopenia.

Pathways for Heparin-Induced Thrombocytopenia

GO Terms for Heparin-Induced Thrombocytopenia

Cellular components related to Heparin-Induced Thrombocytopenia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.43 CD40LG F10 F3 FCGR2A SELP SERPINC1
2 intrinsic component of external side of plasma membrane GO:0031233 8.62 F10 F3

Biological processes related to Heparin-Induced Thrombocytopenia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 9.33 F10 F3 SERPINC1
2 positive regulation of protein kinase B signaling GO:0051897 9.32 F10 F3
3 leukocyte cell-cell adhesion GO:0007159 9.26 CD40LG SELP
4 blood coagulation, extrinsic pathway GO:0007598 8.96 F10 F3
5 hemostasis GO:0007599 8.8 F10 F3 SERPINC1

Molecular functions related to Heparin-Induced Thrombocytopenia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 8.96 F3 SERPINC1
2 phospholipid binding GO:0005543 8.62 F10 F3

Sources for Heparin-Induced Thrombocytopenia

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