HAT
MCID: HPR003
MIFTS: 45

Heparin-Induced Thrombocytopenia (HAT) malady

Blood diseases category

Summaries for Heparin-Induced Thrombocytopenia

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Heparin-induced thrombocytopenia (hit) is an adverse reaction to the drug heparin resulting in an abnormally low amount of platelets (thrombocytopenia). hit is usually an immune response which typically occurs 4-10 days after exposure to heparin; it can lead to serious complications and be life-threatening. this condition occurs in up to 5% of those who are exposed to heparin. characteristic signs of hit are a drop in platelet count of  greater than 50% and/or the formation of new blood clots during heparin therapy.  the first step of treatment is to discontinue and avoid all heparin products immediately. often, affected individuals require another medicine to prevent blood clotting (anticoagulants). last updated: 5/3/2012

MalaCards: Heparin-Induced Thrombocytopenia, also known as hit, is related to thrombocytopenia and pulmonary embolism. An important gene associated with Heparin-Induced Thrombocytopenia is F3 (coagulation factor III (thromboplastin, tissue factor)), and among its related pathways are GP1b-IX-V activation signalling and Platelet Adhesion to exposed collagen. The compounds cardiolipin and dextran sulfate have been mentioned in the context of this disorder. Affiliated tissues include testes, and related mouse phenotypes are cardiovascular system and immune system.

Wikipedia:63 Heparin-induced thrombocytopenia (HIT) is the development of thrombocytopenia (a low platelet count),... more...

Aliases & Classifications for Heparin-Induced Thrombocytopenia

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Sources:
42NIH Rare Diseases, 48Orphanet, 60UMLS, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Blood diseases


Characteristics (Orphanet epidemiological data):

48
heparin-induced thrombocytopenia:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

heparin-induced thrombocytopenia 42 48 60
hit 42 48
heparin-induced thrombocytopenia type 2 48
heparin-associated thrombocytopenia 48
hat 48


External Ids:

ICD10 via Orphanet26 D69.5
SNOMED-CT via Orphanet57 73397007
UMLS via Orphanet61 C0272285

Related Diseases for Heparin-Induced Thrombocytopenia

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17GeneCards, 18GeneDecks
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Diseases related to Heparin-Induced Thrombocytopenia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 341)
idRelated DiseaseScoreTop Affiliating Genes
1thrombocytopenia32.3CD40LG, CD79A, PF4, F3, GP1BA, GP5
2pulmonary embolism31.0SERPINC1, F2, TNXA, F5, F10, PF4
3antiphospholipid syndrome30.8F10, CD40LG, CD79A, PF4, F3, F2
4acute myocardial infarction30.6SERPINC1, PPBP, ITGA2B, F10, PF4, F3
5myocardial infarction30.6F5, F10, PF4, F3, GP1BA, SELP
6polycythemia30.6PPBP
7coronary thrombosis30.6F3, SERPINC1
8polycythemia vera30.6PF4, THBD, SELP
9hepatitis30.6F2, CD40LG, F10
10lupus erythematosus30.5F5, CD40LG, SERPINC1, THBD, F2, F3
11systemic lupus erythematosus30.5F10, CD40LG, CD79A, F3, F2, FCGR2A
12sagittal sinus thrombosis30.4F5, SERPINC1
13stroke, ischemic30.4F2, F5
14leukemia30.3PPBP, ITGA2B, F10, CD40LG, CD79A, PF4
15pancreatitis30.2SELP
16endocarditis30.2F10
17carotid artery thrombosis30.2F3
18purpura30.2CD79A, SERPINC1
19hepatic vein thrombosis30.2F5, SERPINC1
20mitral valve stenosis30.2PPBP, PF4, SELP
21ischemia30.2AZU1, F10, PF4, SELP
22protein c deficiency30.2F5, F2, THBD, SERPINC1
23connective tissue disease30.2THBD, F2, F3, CD79A, CD40LG
24congenital heart defect30.2PPBP, CD40LG, CD79A, SELP, THBD, F2
25disseminated intravascular coagulation30.2THBD, SERPINC1, F2, F3, PF4, TNXA
26thrombocytosis30.2PPBP, F10, PF4, F3, GP1BA, F2
27adult respiratory distress syndrome30.2F5, THBD, SELP
28arthritis30.1FCGR3A, FCGR2A, F10
29rheumatoid arthritis30.1PPBP, F10, CD40LG, CD79A, PF4, FCGR2A
30atherosclerosis30.1PPBP, ITGA2B, CD40LG, PF4, SERPINC1, SELP
31colorectal cancer29.9SELP, PF4
32malaria29.9FCGR2A
33asthma29.8CD79A, F10, PPBP
34hemolytic-uremic syndrome29.7THBD
35hepatitis a29.7F2
36hepatitis c29.7CD40LG, F2
37prostatitis29.7CD79A
38psoriasis29.7SELP, FCGR3A
39adenocarcinoma29.7THBD, PF4, TNXA
40breast cancer29.7PPBP, F10, GP1BA
41hypertension29.7PPBP, F5, CD79A, F2
42primary biliary cirrhosis29.7CD40LG, CD79A, F2
43vasculitis29.7PPBP, CD40LG, CD79A, F2, THBD, SELP
44coronary artery disease29.7PPBP, ITGA2B, F10, PF4, F3, GP1BA
45diabetes mellitus29.7ITGA2B, F10, CD40LG, CD79A, PF4, GP1BA
46cerebritis10.6
47hemoglobinuria10.5
48myocarditis10.4
49obesity10.4
50trypanosomiasis10.3

Graphical network of the top 20 diseases related to Heparin-Induced Thrombocytopenia:



Diseases related to heparin-induced thrombocytopenia

Clinical Features for Heparin-Induced Thrombocytopenia

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Drugs & Therapeutics for Heparin-Induced Thrombocytopenia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Heparin-Induced Thrombocytopenia

Drug clinical trials:

Search ClinicalTrials for Heparin-Induced Thrombocytopenia

Search NIH Clinical Center for Heparin-Induced Thrombocytopenia

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Genetic Tests for Heparin-Induced Thrombocytopenia

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Anatomical Context for Heparin-Induced Thrombocytopenia

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32MalaCards
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MalaCards organs/tissues related to Heparin-Induced Thrombocytopenia:

32
Testes

Animal Models for Heparin-Induced Thrombocytopenia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Heparin-Induced Thrombocytopenia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053859.5F10, CD40LG, F3, F2, SELP, ITGA2B
2MP:00053878.6F3, CD79A, CD40LG, ITGA2B, F2, FCGR2A
3MP:00053978.6ITGA2B, CD40LG, CD79A, PF4, F3, GP1BA
4MP:00053768.1SERPINC1, ITGA2B, F5, F10, CD40LG, CD79A

Publications for Heparin-Induced Thrombocytopenia

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Genetic Variations for Heparin-Induced Thrombocytopenia

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Expression for genes affiliated with Heparin-Induced Thrombocytopenia

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Heparin-Induced Thrombocytopenia

Search GEO for disease gene expression data for Heparin-Induced Thrombocytopenia.

Pathways for genes affiliated with Heparin-Induced Thrombocytopenia

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Sources:
53Reactome, 49PharmGKB, 29KEGG, 37NCBI BioSystems Database, 51QIAGEN, 52R&D Systems
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Pathways related to Heparin-Induced Thrombocytopenia according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1GP5, GP1BA
210.1GP5, GP1BA
3
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10.0FCGR3A, FCGR2A, CD40LG
4
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10.0F10, F3, F2
510.0SELP, FCGR3A, FCGR2A
610.0SELP, THBD, F2
79.9ITGA2B, GP1BA, GP5
89.9ITGA2B, GP5, F2
9
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9.7F2, GP5, GP1BA, ITGA2B
10
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9.6F5, F10, F3, F2, THBD, SERPINC1
11
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9.6F5, F10, F3, F2, THBD, SERPINC1
12
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9.6PF4, F10, F5, ITGA2B, PPBP
13
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9.5PPBP, ITGA2B, F5, PF4, SELP
14
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9.4ITGA2B, F5, F10, F3, F2, THBD
15
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9.3F3, GP1BA, GP5, F2, THBD, SELP
16
Hide members
9.2SERPINC1, F5, F10, F3, GP1BA, GP5

Compounds for genes affiliated with Heparin-Induced Thrombocytopenia

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Sources:
44Novoseek, 11DrugBank, 49PharmGKB, 24HMDB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Heparin-Induced Thrombocytopenia according to GeneCards/GeneDecks:

(show top 50)    (show all 201)
idCompoundScoreTop Affiliating Genes
1cardiolipin44 1111.7F10
2dextran sulfate4410.2F5, F10, CD40LG, SELP
3kininogen4410.1F3, SERPINC1, F2, F5, GP1BA
4ecarin4410.1F10, F3, F2, F5, SERPINC1
5spectrozyme4410.0F5, F10, F3, SERPINC1, F2
6ximelagatran44 1111.0F5, F10, F3, F2, THBD, SERPINC1
7nadroparin44 1111.0F10, SERPINC1, F3, SELP, TNXA
8heparinoids4410.0F5, F10, F3, F2, THBD, SERPINC1
9warfarin44 49 11 2413.0PPBP, CD79A, PF4, SELP, SERPINC1
10adp44 28 2412.0ITGA2B, CD40LG, PPBP, PF4
11ppack449.9F10, CD40LG, F3, F2, SERPINC1, SELP
12inogatran449.9F2, SERPINC1, F3, F5
13ancrod449.9F5, THBD, SERPINC1, F2, F10
14tinzaparin44 1110.9F10, F3, AZU1, TNXA, SERPINC1
15phosphatidylserine44 28 1111.8TNXA, F2, GP1BA, F3, CD79A, F10
16protamine sulfate449.7AZU1, F5, F10, PF4, F3, F2
17ristocetin449.7PPBP, F5, F3, GP1BA, F2, SELP
18danaparoid449.7SERPINC1, F2, F3, TNXA, F5, F10
1911-dehydrothromboxane b2449.7THBD, PPBP, F2, PF4, SELP
20gamma-carboxyglutamic acid449.7TNXA, F5, F10, PF4, F3, F2
21serine449.6GP1BA, FCGR2A, AZU1, ITGA2B, F10
22tirofiban44 1110.6ITGA2B, F10, CD40LG, PF4, F2, SELP
23iloprost44 59 28 1112.6THBD, SERPINC1, PPBP, PF4, F3, SELP
24bivalirudin44 1110.6TNXA, F5, F10, F3, F2, THBD
25ticlopidine44 1110.6F3, PPBP, SERPINC1, SELP, PF4
26argatroban44 1110.6THBD, SELP, SERPINC1, F2, F3, F10
27desmopressin44 59 28 1112.6PPBP, F5, F3, GP1BA, F2, THBD
28protamine449.6TNXA, F5, F10, PF4, F3, F2
29fondaparinux449.6TNXA, F5, F10, PF4, F3, F2
30clopidogrel49 44 11 2412.5SERPINC1, TNXA, PPBP, F10, CD40LG, F3
31hirugen449.5F5, F2, THBD, SERPINC1
32polyethylene glycol449.5THBD, F5, F10, CD40LG, CD79A, PF4
33dipyridamole44 59 28 1112.5SELP, F2, F3, CD79A, PF4, PPBP
34penicillin449.4SELP, PPBP, F2, CD79A, F5
35aprotinin44 1110.4SERPINC1, SELP, AZU1, PPBP, F5, F10
36prostacyclin449.3THBD, SELP, SERPINC1, PPBP, FCGR2A, GP1BA
37dermatan sulfate449.2TNXA, F5, F10, PF4, F3, F2
38citrate449.2F10, CD79A, PF4, F3, THBD, PPBP
39abciximab44 1110.1ITGA2B, F10, CD40LG, PF4, F3, GP1BA
40epinephrine44 11 2411.1FCGR2A, F2, GP1BA, F3, PF4, CD79A
41hirudin449.1F3, GP1BA, F2, THBD, SELP, SERPINC1
42heparin44 28 11 2412.0CD40LG, GP1BA, F10, PPBP, AZU1, CD79A
43polysaccharide448.9F3, CD40LG, FCGR2A, THBD, SELP, SERPINC1
44creatinine448.8CD79A, PF4, F3, F2, SERPINC1, THBD
45lactate448.8PF4, GP1BA, GP5, F2, THBD, SELP
46vegf448.7F10, AZU1, PPBP, CD40LG, SERPINC1, SELP
47arginine448.7SERPINC1, THBD, FCGR3A, SELP, AZU1, TNXA
48alanine448.6SERPINC1, F3, TNXA, THBD, F2, PPBP
49aspirin44 49 28 2411.4PF4, CD79A, CD40LG, F10, F5, PPBP
50fibrinogen448.2TNXA, PPBP, ITGA2B, F5, F10, CD40LG

GO Terms for genes affiliated with Heparin-Induced Thrombocytopenia

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16Gene Ontology
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Cellular components related to Heparin-Induced Thrombocytopenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule membraneGO:03109210.1SELP, ITGA2B
2intrinsic to external side of plasma membraneGO:03123310.1F10, F3
3external side of plasma membraneGO:0098979.7ITGA2B, CD40LG, CD79A, FCGR3A, SELP
4platelet alpha granule lumenGO:0310939.6PF4, F5, PPBP
5extracellular spaceGO:0056159.2PPBP, F5, CD40LG, PF4, F3, F2
6extracellular regionGO:0055769.0AZU1, PPBP, F5, F10, PF4, F2
7plasma membraneGO:0058868.3SERPINC1, ITGA2B, F5, F10, CD40LG, CD79A

Biological processes related to Heparin-Induced Thrombocytopenia according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1blood coagulation, extrinsic pathwayGO:00759810.3F3, F10
2B cell proliferationGO:04210010.1CD79A, CD40LG
3regulation of blood coagulationGO:03019310.1F2, GP1BA
4negative regulation of platelet activationGO:01054410.0GP5, F2, THBD
5negative regulation of fibrinolysisGO:05191810.0F2, THBD
6blood coagulation, intrinsic pathwayGO:0075979.9F10, GP1BA, GP5, F2
7peptidyl-glutamic acid carboxylationGO:0171879.8F2, F10
8platelet degranulationGO:0025769.7SELP, PF4, F5, ITGA2B, PPBP
9cell adhesionGO:0071559.6ITGA2B, F5, GP1BA, GP5, SELP
10platelet activationGO:0301689.0PPBP, ITGA2B, F5, CD40LG, PF4, GP1BA
11blood coagulationGO:0075968.6SERPINC1, PPBP, ITGA2B, F5, F10, PF4

Molecular functions related to Heparin-Induced Thrombocytopenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1IgG bindingGO:01986410.2FCGR3A, FCGR2A
2heparin bindingGO:0082019.5SERPINC1, SELP, PF4, AZU1

Products for genes affiliated with Heparin-Induced Thrombocytopenia

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Sources for Heparin-Induced Thrombocytopenia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet