Aliases & Classifications for Hepatic Angiomyolipoma

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Hepatic Angiomyolipoma, Aliases & Descriptions:

Name: Hepatic Angiomyolipoma 9 60


External Ids:

Disease Ontology9 DOID:3317
NCIt38 C27485

Summaries for Hepatic Angiomyolipoma

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MalaCards based summary: Hepatic Angiomyolipoma is related to angiomyolipoma and tuberous sclerosis. An important gene associated with Hepatic Angiomyolipoma is DES (desmin), and among its related pathways are Cytoplasmic microtubules and Striated Muscle Contraction. The compounds orcein and s 100 have been mentioned in the context of this disorder. Affiliated tissues include liver, small intestine and testes, and related mouse phenotypes are pigmentation and respiratory system.

Related Diseases for Hepatic Angiomyolipoma

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Diseases related to Hepatic Angiomyolipoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 93)
idRelated DiseaseScoreTop Affiliating Genes
1angiomyolipoma31.8DES, VIM, TSC1
2tuberous sclerosis31.0VIM, TSC1
3lymphangioleiomyomatosis30.8DES, TSC1
4hepatocellular carcinoma30.2CDKN2A, RB1, MYC
5rhabdomyosarcoma30.0DES, VIM, RB1
6melanoma29.3CDKN2A, RB1, MYC, VIM, DES
7hepatitis11.1
8infantile myofibromatosis10.5DES
9subependymal giant cell astrocytoma10.5TSC1
10adenomatoid tumor10.4VIM
11epithelioid leiomyosarcoma10.3DES, VIM
12mesenchymal chondrosarcoma10.3DES, VIM
13pseudosarcomatous fibromatosis10.3DES, VIM
14spindle cell carcinoma10.3VIM, DES
15spindle cell sarcoma10.3DES, VIM
16alveolar soft-part sarcoma10.3DES, VIM
17sertoli cell tumor10.3VIM, DES
18granular cell tumor10.3DES, VIM
19dermatofibrosarcoma protuberans10.3DES, VIM
20fibrous histiocytoma10.3DES, VIM
21endometrial stromal sarcoma10.3DES, VIM
22hemangioma10.3
23rhabdoid tumor10.3DES, VIM
24hemangiopericytoma10.2DES, VIM
25sex cord-gonadal stromal tumor10.2DES, VIM
26glomus tumor10.2DES, VIM
27malignant mixed mullerian tumor10.2DES, VIM
28fibromatosis10.2VIM, DES
29chordoma10.2DES, VIM
30smooth muscle tumor10.2DES, VIM
31abrikosov's tumor10.2DES, VIM
32giant cell tumor10.2DES, VIM
33malignant fibroxanthoma10.2DES, VIM
34pleomorphic adenoma10.2DES, VIM
35sarcoma, synovial10.2VIM, DES
36gastrointestinal stromal tumor10.2DES, VIM
37neurilemmoma10.2VIM, DES
38oxyphilic adenoma10.2VIM, TSC1
39malignant peripheral nerve sheath tumor10.2VIM, CDKN2A
40polycystic kidney disease, autosomal dominant10.1TSC1, MYC
41leiomyoma10.1VIM, DES
42dedifferentiated liposarcoma10.1DES, RB1
43precursor b-cell acute lymphoblastic leukemia10.1CDKN2A, MYC
44rhabdomyosarcoma 2, alveolar10.1DES, RB1
45neurofibromatosis, type 210.1
46arteriovenous fistula10.1
47ulcerative colitis10.1
48neurofibromatosis10.1
49giant hemangioma10.1
50cavernous hemangioma10.1

Graphical network of the top 20 diseases related to Hepatic Angiomyolipoma:



Diseases related to hepatic angiomyolipoma

Symptoms for Hepatic Angiomyolipoma

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Drugs & Therapeutics for Hepatic Angiomyolipoma

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Drug clinical trials:

Search ClinicalTrials for Hepatic Angiomyolipoma

Search NIH Clinical Center for Hepatic Angiomyolipoma

Genetic Tests for Hepatic Angiomyolipoma

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Anatomical Context for Hepatic Angiomyolipoma

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MalaCards organs/tissues related to Hepatic Angiomyolipoma:

31
Liver, Small intestine, Testes

Animal Models for Hepatic Angiomyolipoma or affiliated genes

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MGI Mouse Phenotypes related to Hepatic Angiomyolipoma:

35 (show all 17)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011868.6MYC, RB1, CDKN2A
2MP:00053888.3CDKN2A, RB1, TSC1, VIM
3MP:00020068.3MYC, TSC1, RB1, CDKN2A
4MP:00053708.3CDKN2A, RB1, TSC1, MYC
5MP:00107718.1CDKN2A, RB1, TSC1, MYC
6MP:00053798.0MYC, TSC1, RB1, CDKN2A
7MP:00053857.9DES, VIM, MYC, TSC1, RB1
8MP:00053807.8VIM, MYC, TSC1, RB1, CDKN2A
9MP:00053897.8VIM, MYC, TSC1, RB1, CDKN2A
10MP:00053907.8MYC, TSC1, RB1, CDKN2A
11MP:00053847.7VIM, MYC, TSC1, RB1, CDKN2A
12MP:00036317.6VIM, MYC, TSC1, RB1, CDKN2A
13MP:00053787.5CDKN2A, RB1, TSC1, MYC, VIM
14MP:00053697.4CDKN2A, RB1, TSC1, MYC, VIM, DES
15MP:00053867.4DES, VIM, MYC, TSC1, RB1, CDKN2A
16MP:00053767.4DES, VIM, MYC, TSC1, RB1, CDKN2A
17MP:00107687.4DES, VIM, MYC, TSC1, RB1, CDKN2A

Publications for Hepatic Angiomyolipoma

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Articles related to Hepatic Angiomyolipoma:

(show top 50)    (show all 120)
idTitleAuthorsYear
1
Liver transplantation for recurrent posthepatectomy malignant hepatic angiomyolipoma: A case report. (25834347)
2015
2
Myomatous hepatic angiomyolipoma: imaging findings in 14 cases with radiological-pathological correlation and review of the literature. (24670055)
2014
3
Hepatic angiomyolipoma: what management? (25073214)
2014
4
Comparison of MRI features for the differentiation of hepatic angiomyolipoma from fat-containing hepatocellular carcinoma. (24389893)
2014
5
Alterations of the mTOR Pathway in Hepatic Angiomyolipoma with Emphasis on the Epithelioid Variant and Loss of Heterogeneity of the TSC1/TSC2 Genes. (25234729)
2014
6
Immunohistochemical character of hepatic angiomyolipoma: for its management. (23864864)
2013
7
Early venous return in hepatic angiomyolipoma due to an intratumoral structure resembling an arteriovenous fistula. (23679956)
2013
8
Hepatic angiomyolipoma and neurofibromatosis type 2: a novel association. (24314304)
2013
9
Hepatic angiomyolipoma: CT and MR imaging findings with clinical-pathologic comparison. (22996326)
2013
10
Hepatic angiomyolipoma with minimal fat, mimicking hepatocellular carcinoma. (23091816)
2012
11
Hepatic angiomyolipoma with a giant hemangioma. (22041879)
2011
12
Characteristics and treatment strategy of hepatic angiomyolipoma: a series of 94 patients collected from four institutions. (21451800)
2011
13
Development of hepatic angiomyolipoma accompanied with focal nodular hyperplasia long after treatment of pelvic rhabdomyosarcoma. (21683235)
2011
14
Diagnostic difficulties and treatment strategy of hepatic angiomyolipoma. (22464831)
2011
15
Liver transplantation for giant hepatic angiomyolipoma. (21462294)
2011
16
Hepatic angiomyolipoma and intramural small intestinal schwannoma: a coincidence or a relationship? (19282295)
2010
17
F-18 FDG PET/CT findings in two patients with hepatic angiomyolipoma with and without intratumoral hemorrhage. (20026966)
2010
18
Hemodynamic characterization of hepatic angiomyolipoma with least amount of fat evaluated by contrast-enhanced magnetic resonance angiography. (19319591)
2010
19
Hepatic angiomyolipoma: a case report. (20518257)
2010
20
Assessment of triple-phase CT findings for the differentiation of fat-deficient hepatic angiomyolipoma from hepatocellular carcinoma in non-cirrhotic liver. (19200676)
2010
21
Hepatic angiomyolipoma: dynamic computed tomography features and clinical correlation. (19610144)
2009
22
Wunderlich's syndrome with hepatic angiomyolipoma in tuberous sclerosis. (18626151)
2008
23
Clinical features of hepatic angiomyolipoma. (18522883)
2008
24
Massive hepatic angiomyolipoma in a young woman with tuberous sclerosis complex: significant clinical improvement during tamoxifen treatment. (18436329)
2008
25
Hepatic angiomyolipoma. (18834230)
2008
26
Management of hepatic angiomyolipoma. (17436129)
2007
27
Invasive growth of hepatic angiomyolipoma; a hitherto unreported ominous histological feature. (16722932)
2006
28
Hepatic angiomyolipoma with trace amounts of fat: a case report and literature review. (17071805)
2006
29
Hepatic angiomyolipoma: identification of an efferent vessel to be hepatic vein by contrast-enhanced harmonic ultrasound. (16177023)
2005
30
Hepatic angiomyolipoma demonstrating similar imaging characteristics as hepatocellular carcinoma: one case report. (16463691)
2005
31
Contrast-enhanced ultrasonography in hepatic angiomyolipoma. (15914690)
2005
32
Hepatic angiomyolipoma and hepatic stellate cells share a similar gene expression profile. (15891994)
2005
33
Growth of hepatic angiomyolipoma indicating malignant potential. (15482547)
2004
34
A solitary hepatic lesion: MRI-pathological correlation of an hepatic angiomyolipoma (2004:4b). (15221270)
2004
35
Hepatic angiomyolipoma. (12773992)
2003
36
Hepatic angiomyolipoma associated with splenic hamartoma. (11929179)
2002
37
Common and epithelioid variants of hepatic angiomyolipoma exhibit clonal growth and share a distinctive immunophenotype. (10915726)
2000
38
Hepatic angiomyolipoma-misdiagnosis as hepatocellular carcinoma: A report of 14 cases. (11819659)
2000
39
US power Doppler of hepatic angiomyolipoma with low fat content. (10879706)
2000
40
Hepatic angiomyolipoma: a clinicopathologic study of 30 cases and delineation of unusual morphologic variants. (9888702)
1999
41
Hepatic angiomyolipoma with 'oncocyte-like' features. (9870158)
1998
42
Spontaneous rupture of a hepatic angiomyolipoma: CT findings and literature review. (9087353)
1997
43
Hepatic angiomyolipoma: two case reports of caudate-based lesions and review of the literature. (9377758)
1997
44
Hepatic angiomyolipoma: a report of two cases. (8820041)
1996
45
Hepatic angiomyolipoma with minimal fat content: MR demonstration. (8897374)
1996
46
Hepatic angiomyolipoma. (7820028)
1994
47
Hepatic angiomyolipoma pre-operatively diagnosed by imaging. (8218999)
1993
48
Hepatic angiomyolipomas with a deceptive trabecular pattern and HMB-45 reactivity. (1334941)
1992
49
Hepatic angiomyolipoma in a tuberous sclerosis patient. (2401620)
1990
50
Hepatic angiomyolipoma in a tuberous sclerosis patient. (2668223)
1989

Variations for Hepatic Angiomyolipoma

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Expression for genes affiliated with Hepatic Angiomyolipoma

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Search GEO for disease gene expression data for Hepatic Angiomyolipoma.

Pathways for genes affiliated with Hepatic Angiomyolipoma

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Pathways related to Hepatic Angiomyolipoma according to GeneCards Suite gene sharing:

(show all 36)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5DES, VIM
2
Show member pathways
Signaling by Aurora kinases36
Aurora C signaling36
9.5DES, VIM
39.4TSC1, MYC
4
Show member pathways
Development IGF RI signaling
Immune response IL 4 signaling pathway58
Signal transduction AKT signaling58
9.4TSC1, MYC
59.4TSC1, MYC
6
Show member pathways
9.3MYC, CDKN2A
79.1CDKN2A, RB1
8
Show member pathways
9.1CDKN2A, RB1
99.1CDKN2A, RB1
10
Show member pathways
FAS pathway and Stress induction of HSP regulation36
Apoptosis and survival FAS signaling cascades58
Caspase cascade in apoptosis36
9.1VIM, RB1
119.0MYC, RB1
12
Show member pathways
Cell cycle ESR1 regulation of G1 S transition58
Immune response MIF JAB1 signaling58
Cell cycle Cell cycle generic schema 58
9.0RB1, MYC
139.0RB1, MYC
149.0RB1, MYC
159.0MYC, RB1
169.0RB1, MYC
178.8VIM, MYC, CDKN2A
18
Show member pathways
Prostate Cancer36
Integrated Cancer pathway36
Steroid Biosynthesis36
8.6MYC, TSC1, RB1
198.6MYC, TSC1, RB1
20
Show member pathways
8.5CDKN2A, RB1, MYC
218.5CDKN2A, RB1, MYC
228.5CDKN2A, RB1, MYC
23
Show member pathways
8.5MYC, RB1, CDKN2A
24
Show member pathways
DNA damage response36
8.5MYC, RB1, CDKN2A
25
Show member pathways
Cell cycle36
8.5MYC, RB1, CDKN2A
268.5MYC, RB1, CDKN2A
27
Show member pathways
8.5CDKN2A, RB1, MYC
28
Show member pathways
8.5MYC, RB1, CDKN2A
29
Show member pathways
8.5MYC, RB1, CDKN2A
308.5RB1, MYC, VIM
31
Show member pathways
Proteasome Degradation36
Immune response Antigen presentation by MHC class I58
8.5RB1, MYC, VIM
328.5RB1, MYC, VIM
33
Show member pathways
Signaling Pathways in Glioblastoma36
8.1CDKN2A, RB1, TSC1, MYC
348.1CDKN2A, RB1, TSC1, MYC
35
Show member pathways
7.1CDKN2A, DES, VIM, MYC, TSC1, RB1

Compounds for genes affiliated with Hepatic Angiomyolipoma

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Compounds related to Hepatic Angiomyolipoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 101)
idCompoundScoreTop Affiliating Genes
1orcein439.9VIM, DES
2s 100439.8DES, VIM
3tachyplesin i439.7CDKN2A, MYC
4toluidine439.5DES, VIM
5hematoxylin439.4DES, VIM, CDKN2A
6azathioprine43 2 49 1212.4CDKN2A, VIM, DES
74-(methylnitrosamino)-1-(3-pyridyl)-1-butanone439.4CDKN2A, RB1
8guanosine43 24 1211.3VIM, TSC1, CDKN2A
9amsacrine43 1210.2MYC, VIM
10hyaluronic acid43 2410.2MYC, VIM, DES
11folate439.0VIM, MYC, CDKN2A
12formaldehyde43 2410.0RB1, VIM, DES
135-aza-2deoxycytidine439.0VIM, MYC, CDKN2A
14thymidylate438.9VIM, RB1, CDKN2A
15hmba438.9CDKN2A, RB1, MYC
16depsipeptide438.9CDKN2A, RB1, MYC
17n-(4-hydroxyphenyl)retinamide438.9VIM, MYC, RB1
18glycogen43 249.8DES, VIM, MYC, TSC1
19hpvs438.8RB1, CDKN2A
20camptothecin43 59 1210.8MYC, RB1, CDKN2A
21biotin43 24 1210.6DES, VIM, RB1, CDKN2A
22dmso438.6RB1, MYC, VIM
23cyclic amp43 249.5DES, VIM, RB1, CDKN2A
24bromodeoxyuridine438.5DES, VIM, MYC, RB1
25progesterone43 28 59 24 1212.5DES, VIM, RB1, CDKN2A
2612-o-tetradecanoylphorbol 13-acetate438.5DES, VIM, MYC, RB1
27h2o2438.5CDKN2A, RB1, VIM, DES
28vitamin a43 24 1210.5RB1, MYC, VIM
29testosterone43 59 24 1211.5CDKN2A, RB1, VIM, DES
30rapamycin438.4RB1, TSC1, MYC, VIM
31roscovitine438.4CDKN2A, RB1, MYC, VIM
32vincristine43 49 1210.4CDKN2A, RB1, MYC, VIM
33cytarabine43 49 1210.4VIM, MYC, RB1, CDKN2A
34alanine438.4VIM, MYC, TSC1, CDKN2A
35agar438.4VIM, MYC, RB1, CDKN2A
36butyrate438.4VIM, MYC, RB1, CDKN2A
37paclitaxel43 49 1210.4CDKN2A, RB1, MYC, VIM
38genistein43 28 59 2 24 1213.4CDKN2A, RB1, MYC, VIM
39leucine438.3VIM, MYC, RB1, CDKN2A
40oligonucleotide438.2VIM, MYC, RB1, CDKN2A
41dexamethasone43 49 28 1211.2VIM, MYC, RB1, CDKN2A
42threonine438.1CDKN2A, RB1, TSC1, MYC, DES
43adriamycin438.0DES, VIM, MYC, RB1, CDKN2A
44doxorubicin43 49 1210.0DES, VIM, MYC, RB1, CDKN2A
45actinomycin d438.0CDKN2A, RB1, MYC, VIM, DES
46estrogen438.0DES, VIM, MYC, RB1, CDKN2A
47retinoic acid43 249.0DES, VIM, MYC, RB1, CDKN2A
48paraffin437.6CDKN2A, RB1, TSC1, MYC, VIM, DES
49vegf437.6DES, VIM, MYC, TSC1, RB1, CDKN2A
50serine437.5DES, VIM, MYC, TSC1, RB1, CDKN2A

GO Terms for genes affiliated with Hepatic Angiomyolipoma

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Cellular components related to Hepatic Angiomyolipoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:00058829.5VIM, DES
2protein complexGO:00432348.6CDKN2A, TSC1, MYC

Biological processes related to Hepatic Angiomyolipoma according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:00300499.7VIM, DES
2cell cycle checkpointGO:00000759.3RB1, CDKN2A
3negative regulation of protein kinase activityGO:00064699.2CDKN2A, RB1
4protein stabilizationGO:00508219.2TSC1, CDKN2A
5chromatin remodelingGO:00063389.0RB1, MYC
6Ras protein signal transductionGO:00072659.0CDKN2A, RB1
7positive regulation of transcription, DNA-templatedGO:00458938.6MYC, RB1, CDKN2A
8positive regulation of transcription from RNA polymerase II promoterGO:00459448.5CDKN2A, RB1, MYC
9cell cycle arrestGO:00070508.3CDKN2A, RB1, TSC1, MYC

Molecular functions related to Hepatic Angiomyolipoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:000520010.1DES
2transcription factor bindingGO:00081348.5CDKN2A, RB1, MYC
3identical protein bindingGO:00428028.4RB1, VIM, DES
4protein bindingGO:00055157.0DES, VIM, MYC, TSC1, RB1, CDKN2A

Products for genes affiliated with Hepatic Angiomyolipoma

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Sources for Hepatic Angiomyolipoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet