MCID: HPT006
MIFTS: 33

Hepatic Angiomyolipoma malady

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Hepatic Angiomyolipoma

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Aliases & Descriptions for Hepatic Angiomyolipoma:

Name: Hepatic Angiomyolipoma 11 13 68

Classifications:



External Ids:

Disease Ontology11 DOID:3317
NCIt45 C27485

Summaries for Hepatic Angiomyolipoma

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MalaCards based summary: Hepatic Angiomyolipoma is related to hepatitis and angiomyolipoma. An important gene associated with Hepatic Angiomyolipoma is AFP (Alpha Fetoprotein), and among its related pathways are Wnt Signaling Pathway Netpath and LKB1 signaling events. Affiliated tissues include liver, testes and small intestine, and related mouse phenotypes are Decreased viability and liver/biliary system.

Related Diseases for Hepatic Angiomyolipoma

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Diseases related to Hepatic Angiomyolipoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 53)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis10.7
2angiomyolipoma10.7
3hepatocellular carcinoma10.2
4nonossifying fibromyxoid tumor10.1AFP, KIT
5ovarian germ cell teratoma10.1AFP, KIT
6rectum leiomyoma10.1AFP, KIT
7sphenoid sinus squamous cell carcinoma10.1AFP, KIT
8fallopian tube leiomyoma10.1AFP, KIT
9cranial nerve disease10.1AFP, KIT
10central nervous system sarcoma10.1AFP, KIT
11arthus reaction10.1AFP, KIT
12subendocardial myocardial infarction10.1AFP, KIT
13pneumonia10.1AFP, KIT
14gallbladder cancer10.1KIT, MTOR
15persian gulf syndrome10.1AFP, MYC
16gangliosidosis gm110.1KIT, MTOR
17skin angiosarcoma10.1KIT, MYC
18hemorrhagic proctocolitis10.1MTOR, MYC
19postpartum depression10.1KIT, MYC
20toxascariasis10.0AFP, MYC
21tuberous sclerosis10.0
22glycerol kinase deficiency, adult form10.0KIT, MYC
23multifocal osteogenic sarcoma10.0KIT, MYC
24prostate cancer, hereditary, x-linked 110.0AFP, KIT
25human granulocytic anaplasmosis10.0KIT, MYC
26atopic dermatitis10.0AFP, KIT
27malignant pleural solitary fibrous tumor9.9AFP, KIT, MYC
28proctitis9.9AFP, KIT, MYC
29gastrointestinal lymphoma9.9MTOR, MYC
30extraocular retinoblastoma9.9MYC, RB1
31hereditary renal cell carcinoma9.9AFP, KIT
32integumentary system benign neoplasm9.9MYC, RB1
33post-surgical hypoinsulinemia9.8MYC, RB1
34cranioectodermal dysplasia 19.8KIT, MTOR, MYC
35muscular dystrophy-dystroglycanopathy , type b, 29.8KIT, MTOR, MYC
36thoracic outlet syndrome9.8MYC, RB1
37lymphangioleiomyomatosis9.8
38hemangioma9.8
39extranodal nasal nk/t cell lymphoma9.8KIT, MTOR, RB1
40glucose-6-phosphate translocase deficiency9.7MTOR, MYC, RB1
41adult astrocytic tumour9.7MTOR, MYC, RB1
42neurofibromatosis, type 29.6
43arteriovenous fistula9.6
44ulcerative colitis9.6
45colitis9.6
46disseminated intravascular coagulation9.6
47melanoma9.6
48rhabdomyosarcoma9.6
49cavernous hemangioma9.6
50pancreatitis9.6

Graphical network of the top 20 diseases related to Hepatic Angiomyolipoma:



Diseases related to hepatic angiomyolipoma

Symptoms & Phenotypes for Hepatic Angiomyolipoma

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GenomeRNAi Phenotypes related to Hepatic Angiomyolipoma according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00381-A-19.6KIT, MTOR, MYC

MGI Mouse Phenotypes related to Hepatic Angiomyolipoma according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.9AFP, KIT, MYC, RB1
2MP:00020068.8AFP, KIT, MYC, RB1
3MP:00053808.8KIT, MTOR, MYC, RB1
4MP:00053698.8KIT, MTOR, MYC, RB1
5MP:00030128.7KIT, MTOR, MYC, RB1
6MP:00028738.6KIT, MTOR, MYC, RB1
7MP:00011868.5KIT, MYC, RB1
8MP:00053868.4AFP, KIT, MTOR, MYC, RB1
9MP:00053798.3AFP, KIT, MTOR, MYC, RB1

Drugs & Therapeutics for Hepatic Angiomyolipoma

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Interventional clinical trials:

idNameStatusNCT IDPhase
1A Phase II Study of Orally Administered BEZ235 Monotherapy in Patients With Metastatic or Unresectable Malignant PEComaWithdrawnNCT01690871Phase 2

Search NIH Clinical Center for Hepatic Angiomyolipoma

Genetic Tests for Hepatic Angiomyolipoma

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Anatomical Context for Hepatic Angiomyolipoma

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MalaCards organs/tissues related to Hepatic Angiomyolipoma:

36
Liver, Testes, Small intestine

Publications for Hepatic Angiomyolipoma

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Articles related to Hepatic Angiomyolipoma:

(show top 50)    (show all 131)
idTitleAuthorsYear
1
Hepatic Angiomyolipoma Versus Hepatocellular Carcinoma in the Noncirrhotic Liver on Gadoxetic Acid-Enhanced MRI: A Diagnostic Challenge. (27248975)
2016
2
CD68-Positive Cells in Hepatic Angiomyolipoma. (28030864)
2016
3
Comparison of CT and contrast-enhanced ultrasound findings in hepatic angiomyolipoma with pathological correlations. (26867906)
2016
4
Hepatic angiomyolipoma: differential diagnosis from other liver tumors in a special reference to vascular imaging - importance of early drainage vein. (26943379)
2015
5
Diagnosis of Hepatic Angiomyolipoma by Combination of Baseline and Contrast-Enhanced Ultrasound--A Prospective Study in Non-Cirrhotic Patients. (26147859)
2015
6
Visualizing Central Vessels of Hepatic Angiomyolipoma Devoid of Fat Using a 2D Multi-Breath-Hold Susceptibility-Weighted Imaging. (26114004)
2015
7
Hepatic angiomyolipoma with special attention to radiologic imaging. (26366342)
2015
8
Hepatic angiomyolipoma mimicking hepatocellular carcinoma: magnetic resonance imaging and clinical pathological characteristics in 9 cases. (25803731)
2015
9
Liver transplantation for recurrent posthepatectomy malignant hepatic angiomyolipoma: A case report. (25834347)
2015
10
A rare case of xanthogranulomatous pyelonepheritis with hepatic angiomyolipoma. (26617933)
2015
11
Hepatocellular carcinoma with concomitant hepatic angiomyolipoma and cavernous hemangioma in one patient. (25805953)
2015
12
Hepatic angiomyolipoma growing to cause epigastric discomfort: a case report. (26185889)
2014
13
Comparison of MRI features for the differentiation of hepatic angiomyolipoma from fat-containing hepatocellular carcinoma. (24389893)
2014
14
Myomatous hepatic angiomyolipoma: imaging findings in 14 cases with radiological-pathological correlation and review of the literature. (24670055)
2014
15
Spontaneous rupture of a hepatic angiomyolipoma: Report of a case. (26184024)
2014
16
Alterations of the mTOR Pathway in Hepatic Angiomyolipoma with Emphasis on the Epithelioid Variant and Loss of Heterogeneity of the TSC1/TSC2 Genes. (25234729)
2014
17
Hepatic angiomyolipoma: what management? (25073214)
2014
18
Hepatic angiomyolipoma mimicking hepatocellular carcinoma: magnetic resonance imaging and clinical pathological characteristics in 9 cases. (25526436)
2014
19
Hepatic angiomyolipoma: CT and MR imaging findings with clinical-pathologic comparison. (22996326)
2013
20
Hepatic angiomyolipoma and neurofibromatosis type 2: a novel association. (24314304)
2013
21
Immunohistochemical character of hepatic angiomyolipoma: for its management. (23864864)
2013
22
Early venous return in hepatic angiomyolipoma due to an intratumoral structure resembling an arteriovenous fistula. (23679956)
2013
23
Is surgery necessary for patients with hepatic angiomyolipoma? Retrospective analysis from eight Chinese cases. (23731017)
2013
24
Large hepatic angiomyolipoma. (23433965)
2013
25
Hepatic angiomyolipoma: a case report with diagnostic challenge. (24152510)
2013
26
Fat-deficient hepatic angiomyolipoma: a radiological challenge. (23701714)
2013
27
Hepatic angiomyolipoma: clinical, imaging and pathological features in 178 cases. (23292871)
2013
28
Hepatic angiomyolipoma: a series of six cases with emphasis on pathological-radiological correlations and unusual variants diagnosed by core needle biopsy. (22949933)
2012
29
Diagnosis and treatment of hepatic angiomyolipoma. (24570900)
2012
30
Hepatic angiomyolipoma: contrast patterns with SonoVue-enhanced real-time gray-scale ultrasonography. (22524813)
2012
31
Hepatic angiomyolipoma with minimal fat, mimicking hepatocellular carcinoma. (23091816)
2012
32
Sporadic exophytic hepatic angiomyolipoma. (23060385)
2012
33
Hepatic angiomyolipoma: diagnostic findings and management. (23320180)
2012
34
Hepatic angiomyolipoma with a giant hemangioma. (22041879)
2011
35
Characteristics and treatment strategy of hepatic angiomyolipoma: a series of 94 patients collected from four institutions. (21451800)
2011
36
Diagnosis and treatment of hepatic angiomyolipoma. (21283992)
2011
37
Angiogenesis and lymphangiogenesis in sporadic hepatic angiomyolipoma. (21665376)
2011
38
Liver transplantation for giant hepatic angiomyolipoma. (21462294)
2011
39
Development of hepatic angiomyolipoma accompanied with focal nodular hyperplasia long after treatment of pelvic rhabdomyosarcoma. (21683235)
2011
40
Preoperative radiological characterization of hepatic angiomyolipoma using magnetic resonance imaging and contrast-enhanced ultrasonography: a case report. (21943146)
2011
41
Diagnostic difficulties and treatment strategy of hepatic angiomyolipoma. (22464831)
2011
42
Assessment of triple-phase CT findings for the differentiation of fat-deficient hepatic angiomyolipoma from hepatocellular carcinoma in non-cirrhotic liver. (19200676)
2010
43
Hepatic angiomyolipoma and intramural small intestinal schwannoma: a coincidence or a relationship? (19282295)
2010
44
F-18 FDG PET/CT findings in two patients with hepatic angiomyolipoma with and without intratumoral hemorrhage. (20026966)
2010
45
Hepatic angiomyolipoma: a case report. (20518257)
2010
46
Hepatic angiomyolipoma: a clinical experience in diagnosis and treatment. (20165978)
2010
47
Education and Imaging. Hepatobiliary and pancreatic: imaging for hepatic angiomyolipoma. (20796161)
2010
48
Hemodynamic characterization of hepatic angiomyolipoma with least amount of fat evaluated by contrast-enhanced magnetic resonance angiography. (19319591)
2010
49
Clinical challenges and images in GI. Diagnosis: Hepatic angiomyolipoma mimicking hepatocellular carcinoma. (19254682)
2009
50
Hepatic Angiomyolipoma with Minimal Intratumoral Fat Content. (21103249)
2009

Variations for Hepatic Angiomyolipoma

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Expression for genes affiliated with Hepatic Angiomyolipoma

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Search GEO for disease gene expression data for Hepatic Angiomyolipoma.

Pathways for genes affiliated with Hepatic Angiomyolipoma

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Pathways related to Hepatic Angiomyolipoma according to GeneCards Suite gene sharing:

(show all 27)
idSuper pathwaysScoreTop Affiliating Genes
19.3MTOR, MYC
29.3MTOR, MYC
3
Show member pathways
9.3MTOR, MYC
49.3MTOR, MYC
59.3MTOR, MYC
69.3MTOR, MYC
79.3KIT, MYC
8
Show member pathways
9.3KIT, MYC
99.1MTOR, RB1
109.0MYC, RB1
119.0MYC, RB1
129.0MYC, RB1
139.0MYC, RB1
14
Show member pathways
9.0MYC, RB1
159.0MYC, RB1
169.0MYC, RB1
179.0MYC, RB1
18
Show member pathways
8.8KIT, MTOR, MYC
198.8KIT, MTOR, MYC
208.8KIT, MTOR, MYC
218.5MTOR, MYC, RB1
228.5MTOR, MYC, RB1
23
Show member pathways
8.5MTOR, MYC, RB1
248.5MTOR, MYC, RB1
25
Show member pathways
8.5MTOR, MYC, RB1
26
Show member pathways
8.0KIT, MTOR, MYC, RB1
278.0KIT, MTOR, MYC, RB1

GO Terms for genes affiliated with Hepatic Angiomyolipoma

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Cellular components related to Hepatic Angiomyolipoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1PML bodyGO:00166059.1MTOR, RB1

Biological processes related to Hepatic Angiomyolipoma according to GeneCards Suite gene sharing:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1cellular response to hypoxiaGO:007145610.0MTOR, MYC
2energy reserve metabolic processGO:000611210.0MTOR, MYC
3ovarian follicle developmentGO:000154110.0KIT, MYC
4positive regulation of glial cell proliferationGO:006025210.0MTOR, MYC
5positive regulation of smooth muscle cell proliferationGO:004866110.0MTOR, MYC
6digestive tract developmentGO:00485659.8KIT, RB1
7chromatin remodelingGO:00063389.7MYC, RB1
8G1/S transition of mitotic cell cycleGO:00000829.7MYC, RB1
9regulation of mitotic cell cycleGO:00073469.7MYC, RB1
10positive regulation of gene expressionGO:00106289.5KIT, MTOR, MYC
11visual learningGO:00085429.4KIT, MTOR
12cell cycle arrestGO:00070509.2MTOR, MYC, RB1
13regulation of transcription from RNA polymerase II promoterGO:00063579.0KIT, MYC, RB1

Molecular functions related to Hepatic Angiomyolipoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1phosphoprotein bindingGO:00512199.1MTOR, RB1

Sources for Hepatic Angiomyolipoma

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet