MCID: HPT006
MIFTS: 33

Hepatic Angiomyolipoma malady

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Hepatic Angiomyolipoma

Aliases & Descriptions for Hepatic Angiomyolipoma:

Name: Hepatic Angiomyolipoma 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:3317
NCIt 47 C27485
UMLS 69 C1333962

Summaries for Hepatic Angiomyolipoma

MalaCards based summary : Hepatic Angiomyolipoma is related to hepatitis and angiomyolipoma. An important gene associated with Hepatic Angiomyolipoma is AFP (Alpha Fetoprotein), and among its related pathways/superpathways are Glioma and PI3K-Akt signaling pathway. Affiliated tissues include liver, testes and small intestine, and related phenotypes are Decreased viability and behavior/neurological

Related Diseases for Hepatic Angiomyolipoma

Diseases related to Hepatic Angiomyolipoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)
id Related Disease Score Top Affiliating Genes
1 hepatitis 10.7
2 angiomyolipoma 10.7
3 hepatocellular carcinoma 10.2
4 nonossifying fibromyxoid tumor 10.1 AFP KIT
5 ovarian germ cell teratoma 10.1 AFP KIT
6 rectum leiomyoma 10.1 AFP KIT
7 sphenoid sinus squamous cell carcinoma 10.1 AFP KIT
8 fallopian tube leiomyoma 10.1 AFP KIT
9 cranial nerve disease 10.1 AFP KIT
10 central nervous system sarcoma 10.1 AFP KIT
11 arthus reaction 10.1 AFP KIT
12 subendocardial myocardial infarction 10.1 AFP KIT
13 pneumonia 10.1 AFP KIT
14 gallbladder cancer 10.1 KIT MTOR
15 persian gulf syndrome 10.1 AFP MYC
16 gangliosidosis gm1 10.1 KIT MTOR
17 skin angiosarcoma 10.1 KIT MYC
18 hemorrhagic proctocolitis 10.1 MTOR MYC
19 postpartum depression 10.1 KIT MYC
20 toxascariasis 10.0 AFP MYC
21 tuberous sclerosis 10.0
22 glycerol kinase deficiency, adult form 10.0 KIT MYC
23 multifocal osteogenic sarcoma 10.0 KIT MYC
24 prostate cancer, hereditary, x-linked 1 10.0 AFP KIT
25 human granulocytic anaplasmosis 10.0 KIT MYC
26 atopic dermatitis 10.0 AFP KIT
27 malignant pleural solitary fibrous tumor 9.9 AFP KIT MYC
28 proctitis 9.9 AFP KIT MYC
29 gastrointestinal lymphoma 9.9 MTOR MYC
30 extraocular retinoblastoma 9.9 MYC RB1
31 hereditary renal cell carcinoma 9.9 AFP KIT
32 integumentary system benign neoplasm 9.9 MYC RB1
33 post-surgical hypoinsulinemia 9.8 MYC RB1
34 cranioectodermal dysplasia 1 9.8 KIT MTOR MYC
35 muscular dystrophy-dystroglycanopathy , type b, 2 9.8 KIT MTOR MYC
36 thoracic outlet syndrome 9.8 MYC RB1
37 lymphangioleiomyomatosis 9.8
38 hemangioma 9.8
39 extranodal nasal nk/t cell lymphoma 9.8 KIT MTOR RB1
40 glucose-6-phosphate translocase deficiency 9.7 MTOR MYC RB1
41 adult astrocytic tumour 9.7 MTOR MYC RB1
42 neurofibromatosis, type 2 9.6
43 arteriovenous fistula 9.6
44 ulcerative colitis 9.6
45 colitis 9.6
46 disseminated intravascular coagulation 9.6
47 melanoma 9.6
48 rhabdomyosarcoma 9.6
49 cavernous hemangioma 9.6
50 pancreatitis 9.6

Graphical network of the top 20 diseases related to Hepatic Angiomyolipoma:



Diseases related to Hepatic Angiomyolipoma

Symptoms & Phenotypes for Hepatic Angiomyolipoma

GenomeRNAi Phenotypes related to Hepatic Angiomyolipoma according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.28 MTOR
2 Decreased viability GR00221-A-1 9.28 KIT MTOR MYC
3 Decreased viability GR00221-A-3 9.28 MYC
4 Decreased viability GR00221-A-4 9.28 MTOR
5 Decreased viability GR00301-A 9.28 KIT
6 Decreased viability GR00342-S-1 9.28 MTOR
7 Decreased viability GR00342-S-2 9.28 MTOR

MGI Mouse Phenotypes related to Hepatic Angiomyolipoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.85 AFP KIT MTOR MYC RB1
2 endocrine/exocrine gland MP:0005379 9.8 AFP KIT MTOR MYC RB1
3 embryo MP:0005380 9.73 KIT MTOR MYC RB1
4 liver/biliary system MP:0005370 9.67 AFP KIT MYC RB1
5 muscle MP:0005369 9.62 KIT MTOR MYC RB1
6 neoplasm MP:0002006 9.56 AFP KIT MYC RB1
7 no phenotypic analysis MP:0003012 9.46 KIT MTOR MYC RB1
8 normal MP:0002873 9.26 KIT MTOR MYC RB1
9 pigmentation MP:0001186 8.8 RB1 KIT MYC

Drugs & Therapeutics for Hepatic Angiomyolipoma

Interventional clinical trials:


id Name Status NCT ID Phase
1 A Phase II Study of Orally Administered BEZ235 Monotherapy in Patients With Metastatic or Unresectable Malignant PEComa Withdrawn NCT01690871 Phase 2

Search NIH Clinical Center for Hepatic Angiomyolipoma

Genetic Tests for Hepatic Angiomyolipoma

Anatomical Context for Hepatic Angiomyolipoma

MalaCards organs/tissues related to Hepatic Angiomyolipoma:

39
Liver, Testes, Small Intestine

Publications for Hepatic Angiomyolipoma

Articles related to Hepatic Angiomyolipoma:

(show top 50) (show all 131)
id Title Authors Year
1
Hepatic Angiomyolipoma Versus Hepatocellular Carcinoma in the Noncirrhotic Liver on Gadoxetic Acid-Enhanced MRI: A Diagnostic Challenge. ( 27248975 )
2016
2
CD68-Positive Cells in Hepatic Angiomyolipoma. ( 28030864 )
2016
3
Comparison of CT and contrast-enhanced ultrasound findings in hepatic angiomyolipoma with pathological correlations. ( 26867906 )
2016
4
Hepatic angiomyolipoma: differential diagnosis from other liver tumors in a special reference to vascular imaging - importance of early drainage vein. ( 26943379 )
2015
5
Diagnosis of Hepatic Angiomyolipoma by Combination of Baseline and Contrast-Enhanced Ultrasound--A Prospective Study in Non-Cirrhotic Patients. ( 26147859 )
2015
6
Visualizing Central Vessels of Hepatic Angiomyolipoma Devoid of Fat Using a 2D Multi-Breath-Hold Susceptibility-Weighted Imaging. ( 26114004 )
2015
7
Hepatic angiomyolipoma with special attention to radiologic imaging. ( 26366342 )
2015
8
Hepatic angiomyolipoma mimicking hepatocellular carcinoma: magnetic resonance imaging and clinical pathological characteristics in 9 cases. ( 25803731 )
2015
9
Liver transplantation for recurrent posthepatectomy malignant hepatic angiomyolipoma: A case report. ( 25834347 )
2015
10
A rare case of xanthogranulomatous pyelonepheritis with hepatic angiomyolipoma. ( 26617933 )
2015
11
Hepatocellular carcinoma with concomitant hepatic angiomyolipoma and cavernous hemangioma in one patient. ( 25805953 )
2015
12
Hepatic angiomyolipoma growing to cause epigastric discomfort: a case report. ( 26185889 )
2014
13
Comparison of MRI features for the differentiation of hepatic angiomyolipoma from fat-containing hepatocellular carcinoma. ( 24389893 )
2014
14
Myomatous hepatic angiomyolipoma: imaging findings in 14 cases with radiological-pathological correlation and review of the literature. ( 24670055 )
2014
15
Spontaneous rupture of a hepatic angiomyolipoma: Report of a case. ( 26184024 )
2014
16
Alterations of the mTOR Pathway in Hepatic Angiomyolipoma with Emphasis on the Epithelioid Variant and Loss of Heterogeneity of the TSC1/TSC2 Genes. ( 25234729 )
2014
17
Hepatic angiomyolipoma: what management? ( 25073214 )
2014
18
Hepatic angiomyolipoma mimicking hepatocellular carcinoma: magnetic resonance imaging and clinical pathological characteristics in 9 cases. ( 25526436 )
2014
19
Hepatic angiomyolipoma: CT and MR imaging findings with clinical-pathologic comparison. ( 22996326 )
2013
20
Hepatic angiomyolipoma and neurofibromatosis type 2: a novel association. ( 24314304 )
2013
21
Immunohistochemical character of hepatic angiomyolipoma: for its management. ( 23864864 )
2013
22
Early venous return in hepatic angiomyolipoma due to an intratumoral structure resembling an arteriovenous fistula. ( 23679956 )
2013
23
Is surgery necessary for patients with hepatic angiomyolipoma? Retrospective analysis from eight Chinese cases. ( 23731017 )
2013
24
Large hepatic angiomyolipoma. ( 23433965 )
2013
25
Hepatic angiomyolipoma: a case report with diagnostic challenge. ( 24152510 )
2013
26
Fat-deficient hepatic angiomyolipoma: a radiological challenge. ( 23701714 )
2013
27
Hepatic angiomyolipoma: clinical, imaging and pathological features in 178 cases. ( 23292871 )
2013
28
Hepatic angiomyolipoma: a series of six cases with emphasis on pathological-radiological correlations and unusual variants diagnosed by core needle biopsy. ( 22949933 )
2012
29
Diagnosis and treatment of hepatic angiomyolipoma. ( 24570900 )
2012
30
Hepatic angiomyolipoma: contrast patterns with SonoVue-enhanced real-time gray-scale ultrasonography. ( 22524813 )
2012
31
Hepatic angiomyolipoma with minimal fat, mimicking hepatocellular carcinoma. ( 23091816 )
2012
32
Sporadic exophytic hepatic angiomyolipoma. ( 23060385 )
2012
33
Hepatic angiomyolipoma: diagnostic findings and management. ( 23320180 )
2012
34
Hepatic angiomyolipoma with a giant hemangioma. ( 22041879 )
2011
35
Characteristics and treatment strategy of hepatic angiomyolipoma: a series of 94 patients collected from four institutions. ( 21451800 )
2011
36
Diagnosis and treatment of hepatic angiomyolipoma. ( 21283992 )
2011
37
Angiogenesis and lymphangiogenesis in sporadic hepatic angiomyolipoma. ( 21665376 )
2011
38
Liver transplantation for giant hepatic angiomyolipoma. ( 21462294 )
2011
39
Development of hepatic angiomyolipoma accompanied with focal nodular hyperplasia long after treatment of pelvic rhabdomyosarcoma. ( 21683235 )
2011
40
Preoperative radiological characterization of hepatic angiomyolipoma using magnetic resonance imaging and contrast-enhanced ultrasonography: a case report. ( 21943146 )
2011
41
Diagnostic difficulties and treatment strategy of hepatic angiomyolipoma. ( 22464831 )
2011
42
Assessment of triple-phase CT findings for the differentiation of fat-deficient hepatic angiomyolipoma from hepatocellular carcinoma in non-cirrhotic liver. ( 19200676 )
2010
43
Hepatic angiomyolipoma and intramural small intestinal schwannoma: a coincidence or a relationship? ( 19282295 )
2010
44
F-18 FDG PET/CT findings in two patients with hepatic angiomyolipoma with and without intratumoral hemorrhage. ( 20026966 )
2010
45
Hepatic angiomyolipoma: a case report. ( 20518257 )
2010
46
Hepatic angiomyolipoma: a clinical experience in diagnosis and treatment. ( 20165978 )
2010
47
Education and Imaging. Hepatobiliary and pancreatic: imaging for hepatic angiomyolipoma. ( 20796161 )
2010
48
Hemodynamic characterization of hepatic angiomyolipoma with least amount of fat evaluated by contrast-enhanced magnetic resonance angiography. ( 19319591 )
2010
49
Clinical challenges and images in GI. Diagnosis: Hepatic angiomyolipoma mimicking hepatocellular carcinoma. ( 19254682 )
2009
50
Hepatic Angiomyolipoma with Minimal Intratumoral Fat Content. ( 21103249 )
2009

Variations for Hepatic Angiomyolipoma

Expression for Hepatic Angiomyolipoma

Search GEO for disease gene expression data for Hepatic Angiomyolipoma.

Pathways for Hepatic Angiomyolipoma

Pathways related to Hepatic Angiomyolipoma according to GeneCards Suite gene sharing:

(show all 27)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.56 KIT MTOR MYC RB1
2 12.22 KIT MTOR MYC
3
Show member pathways
12.17 MTOR MYC RB1
4 12.05 KIT MTOR MYC RB1
5
Show member pathways
11.99 KIT MTOR MYC
6
Show member pathways
11.76 MTOR MYC RB1
7 11.69 MTOR MYC RB1
8 11.66 MTOR RB1
9 11.64 MTOR MYC
10 11.62 MTOR MYC
11
Show member pathways
11.59 KIT MYC
12 11.56 MYC RB1
13 11.53 MYC RB1
14 11.49 KIT MYC
15 11.48 MTOR MYC RB1
16 11.45 MYC RB1
17 11.45 MYC RB1
18
Show member pathways
11.4 MTOR MYC
19 11.39 MTOR MYC
20 11.28 MTOR MYC
21 11.23 MYC RB1
22 11.2 MYC RB1
23 11.15 MTOR MYC
24 11.05 MYC RB1
25 10.96 MTOR MYC RB1
26 10.78 MYC RB1
27 10.61 KIT MTOR MYC

GO Terms for Hepatic Angiomyolipoma

Cellular components related to Hepatic Angiomyolipoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 PML body GO:0016605 8.62 MTOR RB1

Biological processes related to Hepatic Angiomyolipoma according to GeneCards Suite gene sharing:

(show all 13)
id Name GO ID Score Top Affiliating Genes
1 regulation of transcription from RNA polymerase II promoter GO:0006357 9.65 KIT MYC RB1
2 cellular response to hypoxia GO:0071456 9.52 MTOR MYC
3 G1/S transition of mitotic cell cycle GO:0000082 9.51 MYC RB1
4 positive regulation of gene expression GO:0010628 9.5 KIT MTOR MYC
5 chromatin remodeling GO:0006338 9.49 MYC RB1
6 positive regulation of smooth muscle cell proliferation GO:0048661 9.46 MTOR MYC
7 visual learning GO:0008542 9.43 KIT MTOR
8 regulation of mitotic cell cycle GO:0007346 9.4 MYC RB1
9 ovarian follicle development GO:0001541 9.37 KIT MYC
10 digestive tract development GO:0048565 9.26 KIT RB1
11 energy reserve metabolic process GO:0006112 9.16 MTOR MYC
12 cell cycle arrest GO:0007050 9.13 MTOR MYC RB1
13 positive regulation of glial cell proliferation GO:0060252 8.62 MTOR MYC

Molecular functions related to Hepatic Angiomyolipoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 phosphoprotein binding GO:0051219 8.62 MTOR RB1

Sources for Hepatic Angiomyolipoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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