MCID: HPT006
MIFTS: 33

Hepatic Angiomyolipoma

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Hepatic Angiomyolipoma

MalaCards integrated aliases for Hepatic Angiomyolipoma:

Name: Hepatic Angiomyolipoma 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:3317
NCIt 47 C27485
UMLS 69 C1333962

Summaries for Hepatic Angiomyolipoma

MalaCards based summary : Hepatic Angiomyolipoma is related to hepatitis and angiomyolipoma. An important gene associated with Hepatic Angiomyolipoma is AFP (Alpha Fetoprotein), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Endometrial cancer. Affiliated tissues include liver, testes and small intestine, and related phenotypes are Decreased viability and behavior/neurological

Related Diseases for Hepatic Angiomyolipoma

Diseases related to Hepatic Angiomyolipoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 55)
id Related Disease Score Top Affiliating Genes
1 hepatitis 10.7
2 angiomyolipoma 10.7
3 giant adenofibroma of the breast 10.3 AFP KIT
4 clear cell squamous cell skin carcinoma 10.3 AFP KIT
5 thymus small cell carcinoma 10.3 AFP KIT
6 sphenoid sinus squamous cell carcinoma 10.3 AFP KIT
7 ovarian cystic teratoma 10.3 AFP KIT
8 malignant teratoma 10.3 AFP KIT
9 urethral villous adenoma 10.2 AFP KIT
10 hypersensitivity reaction type iii disease 10.2 AFP KIT
11 hepatocellular carcinoma 10.2
12 anterolateral myocardial infarction 10.2 AFP KIT
13 nasal cavity squamous cell carcinoma 10.2 AFP KIT
14 central nervous system sarcoma 10.2 AFP KIT
15 gallbladder papillomatosis 10.2 KIT MTOR
16 malignant peritoneal solitary fibrous tumor 10.2 AFP MYC
17 hemoglobinemia 10.1 MTOR MYC
18 gangliosidosis gm2 10.1 KIT MTOR
19 prostate cancer, hereditary, x-linked 1 10.1 AFP KIT
20 thoracic outlet syndrome 10.1 AFP MYC
21 central nervous system disease 10.1 AFP KIT
22 extraosseous osteosarcoma 10.0 KIT MYC
23 tuberous sclerosis 10.0
24 tetrahydrobiopterin-responsive hyperphenylalaninemia/phenylketonuria 10.0 KIT MYC
25 childhood kidney cell carcinoma 10.0 AFP KIT
26 chikungunya 10.0 KIT MYC
27 lymphangioleiomyomatosis 9.8
28 hemangioma 9.8
29 solitary osseous plasmacytoma 9.8 AFP MYC
30 megakaryocytic leukemia 9.7 MTOR MYC
31 unilateral retinoblastoma 9.7 MYC RB1
32 pharynx cancer 9.7 MYC RB1
33 gallbladder cancer 9.7 AFP KIT MYC
34 brown-vialetto-van laere syndrome 9.7 AFP KIT MYC
35 post-surgical hypoinsulinemia 9.6 MYC RB1
36 neurofibromatosis, type 2 9.6
37 arteriovenous fistula 9.6
38 ulcerative colitis 9.6
39 colitis 9.6
40 disseminated intravascular coagulation 9.6
41 melanoma 9.6
42 rhabdomyosarcoma 9.6
43 cavernous hemangioma 9.6
44 pancreatitis 9.6
45 giant hemangioma 9.6
46 cervix uteri carcinoma in situ 9.6 MTOR MYC
47 small cell sarcoma 9.6 MYC RB1
48 leprosy 6 9.6 KIT RB1
49 cranioectodermal dysplasia 1 9.5 KIT MTOR MYC
50 gastric cancer, somatic 9.5 AFP MYC

Graphical network of the top 20 diseases related to Hepatic Angiomyolipoma:



Diseases related to Hepatic Angiomyolipoma

Symptoms & Phenotypes for Hepatic Angiomyolipoma

GenomeRNAi Phenotypes related to Hepatic Angiomyolipoma according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.28 MTOR
2 Decreased viability GR00221-A-1 9.28 KIT MTOR MYC
3 Decreased viability GR00221-A-3 9.28 MYC
4 Decreased viability GR00221-A-4 9.28 MTOR
5 Decreased viability GR00301-A 9.28 KIT
6 Decreased viability GR00342-S-1 9.28 MTOR
7 Decreased viability GR00342-S-2 9.28 MTOR

MGI Mouse Phenotypes related to Hepatic Angiomyolipoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.83 AFP KIT MTOR MYC RB1
2 endocrine/exocrine gland MP:0005379 9.77 AFP KIT MTOR MYC RB1
3 embryo MP:0005380 9.71 KIT MTOR MYC RB1
4 liver/biliary system MP:0005370 9.62 AFP KIT MYC RB1
5 muscle MP:0005369 9.56 KIT MTOR MYC RB1
6 neoplasm MP:0002006 9.46 AFP KIT MYC RB1
7 no phenotypic analysis MP:0003012 9.26 KIT MTOR MYC RB1
8 pigmentation MP:0001186 8.8 KIT MYC RB1

Drugs & Therapeutics for Hepatic Angiomyolipoma

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 A Phase II Study of Orally Administered BEZ235 Monotherapy in Patients With Metastatic or Unresectable Malignant PEComa Withdrawn NCT01690871 Phase 2 BEZ235

Search NIH Clinical Center for Hepatic Angiomyolipoma

Genetic Tests for Hepatic Angiomyolipoma

Anatomical Context for Hepatic Angiomyolipoma

MalaCards organs/tissues related to Hepatic Angiomyolipoma:

39
Liver, Testes, Small Intestine

Publications for Hepatic Angiomyolipoma

Articles related to Hepatic Angiomyolipoma:

(show top 50) (show all 137)
id Title Authors Year
1
The Histopathological Features and CT/MRI Imaging Performances in Hepatic Angiomyolipoma Patients. ( 28809731 )
2017
2
Clinico-pathological correlation of hepatic angiomyolipoma: a series of 23 resection cases. ( 28122404 )
2017
3
Management of hepatic angiomyolipoma: A systematic review. ( 28177188 )
2017
4
A case of ruptured hepatic angiomyolipoma in a young male. ( 28449573 )
2017
5
Hepatic angiomyolipomas may overexpress TFE3, but have no relevant genetic alterations. ( 27865795 )
2017
6
Primary hepatic angiomyolipoma: immunohistochemistry and electron microscopic observations: a case report. ( 28327196 )
2017
7
Comparison of CT and contrast-enhanced ultrasound findings in hepatic angiomyolipoma with pathological correlations. ( 26867906 )
2016
8
Hepatic Angiomyolipoma Versus Hepatocellular Carcinoma in the Noncirrhotic Liver on Gadoxetic Acid-Enhanced MRI: A Diagnostic Challenge. ( 27248975 )
2016
9
CD68-Positive Cells in Hepatic Angiomyolipoma. ( 28030864 )
2016
10
Hepatocellular carcinoma with concomitant hepatic angiomyolipoma and cavernous hemangioma in one patient. ( 25805953 )
2015
11
Hepatic angiomyolipoma mimicking hepatocellular carcinoma: magnetic resonance imaging and clinical pathological characteristics in 9 cases. ( 25803731 )
2015
12
Diagnosis of Hepatic Angiomyolipoma by Combination of Baseline and Contrast-Enhanced Ultrasound--A Prospective Study in Non-Cirrhotic Patients. ( 26147859 )
2015
13
Visualizing Central Vessels of Hepatic Angiomyolipoma Devoid of Fat Using a 2D Multi-Breath-Hold Susceptibility-Weighted Imaging. ( 26114004 )
2015
14
A rare case of xanthogranulomatous pyelonepheritis with hepatic angiomyolipoma. ( 26617933 )
2015
15
Hepatic angiomyolipoma: differential diagnosis from other liver tumors in a special reference to vascular imaging - importance of early drainage vein. ( 26943379 )
2015
16
Liver transplantation for recurrent posthepatectomy malignant hepatic angiomyolipoma: A case report. ( 25834347 )
2015
17
Hepatic angiomyolipoma with special attention to radiologic imaging. ( 26366342 )
2015
18
Myomatous hepatic angiomyolipoma: imaging findings in 14 cases with radiological-pathological correlation and review of the literature. ( 24670055 )
2014
19
Alterations of the mTOR Pathway in Hepatic Angiomyolipoma with Emphasis on the Epithelioid Variant and Loss of Heterogeneity of the TSC1/TSC2 Genes. ( 25234729 )
2014
20
Hepatic angiomyolipoma: what management? ( 25073214 )
2014
21
Hepatic angiomyolipoma mimicking hepatocellular carcinoma: magnetic resonance imaging and clinical pathological characteristics in 9 cases. ( 25526436 )
2014
22
Comparison of MRI features for the differentiation of hepatic angiomyolipoma from fat-containing hepatocellular carcinoma. ( 24389893 )
2014
23
Hepatic angiomyolipoma growing to cause epigastric discomfort: a case report. ( 26185889 )
2014
24
Spontaneous rupture of a hepatic angiomyolipoma: Report of a case. ( 26184024 )
2014
25
Hepatic angiomyolipoma: clinical, imaging and pathological features in 178 cases. ( 23292871 )
2013
26
Hepatic angiomyolipoma: a case report with diagnostic challenge. ( 24152510 )
2013
27
Fat-deficient hepatic angiomyolipoma: a radiological challenge. ( 23701714 )
2013
28
Early venous return in hepatic angiomyolipoma due to an intratumoral structure resembling an arteriovenous fistula. ( 23679956 )
2013
29
Hepatic angiomyolipoma and neurofibromatosis type 2: a novel association. ( 24314304 )
2013
30
Large hepatic angiomyolipoma. ( 23433965 )
2013
31
Hepatic angiomyolipoma: CT and MR imaging findings with clinical-pathologic comparison. ( 22996326 )
2013
32
Immunohistochemical character of hepatic angiomyolipoma: for its management. ( 23864864 )
2013
33
Is surgery necessary for patients with hepatic angiomyolipoma? Retrospective analysis from eight Chinese cases. ( 23731017 )
2013
34
Hepatic angiomyolipoma: diagnostic findings and management. ( 23320180 )
2012
35
Hepatic angiomyolipoma: contrast patterns with SonoVue-enhanced real-time gray-scale ultrasonography. ( 22524813 )
2012
36
Diagnosis and treatment of hepatic angiomyolipoma. ( 24570900 )
2012
37
Sporadic exophytic hepatic angiomyolipoma. ( 23060385 )
2012
38
Hepatic angiomyolipoma with minimal fat, mimicking hepatocellular carcinoma. ( 23091816 )
2012
39
Hepatic angiomyolipoma: a series of six cases with emphasis on pathological-radiological correlations and unusual variants diagnosed by core needle biopsy. ( 22949933 )
2012
40
Characteristics and treatment strategy of hepatic angiomyolipoma: a series of 94 patients collected from four institutions. ( 21451800 )
2011
41
Diagnosis and treatment of hepatic angiomyolipoma. ( 21283992 )
2011
42
Preoperative radiological characterization of hepatic angiomyolipoma using magnetic resonance imaging and contrast-enhanced ultrasonography: a case report. ( 21943146 )
2011
43
Angiogenesis and lymphangiogenesis in sporadic hepatic angiomyolipoma. ( 21665376 )
2011
44
Development of hepatic angiomyolipoma accompanied with focal nodular hyperplasia long after treatment of pelvic rhabdomyosarcoma. ( 21683235 )
2011
45
Liver transplantation for giant hepatic angiomyolipoma. ( 21462294 )
2011
46
Hepatic angiomyolipoma with a giant hemangioma. ( 22041879 )
2011
47
Diagnostic difficulties and treatment strategy of hepatic angiomyolipoma. ( 22464831 )
2011
48
Hepatic angiomyolipoma and intramural small intestinal schwannoma: a coincidence or a relationship? ( 19282295 )
2010
49
Hepatic angiomyolipoma: a clinical experience in diagnosis and treatment. ( 20165978 )
2010
50
Hemodynamic characterization of hepatic angiomyolipoma with least amount of fat evaluated by contrast-enhanced magnetic resonance angiography. ( 19319591 )
2010

Variations for Hepatic Angiomyolipoma

Expression for Hepatic Angiomyolipoma

Search GEO for disease gene expression data for Hepatic Angiomyolipoma.

Pathways for Hepatic Angiomyolipoma

Pathways related to Hepatic Angiomyolipoma according to GeneCards Suite gene sharing:

(show all 25)
id Super pathways Score Top Affiliating Genes
1 12.2 KIT MTOR MYC RB1
2
Show member pathways
12.09 KIT MTOR MYC RB1
3 12.05 KIT MTOR MYC RB1
4
Show member pathways
11.85 MTOR MYC RB1
5 11.69 MTOR MYC RB1
6 11.65 MTOR RB1
7 11.63 MTOR MYC
8 11.61 MTOR MYC
9
Show member pathways
11.57 KIT MYC
10 11.54 MYC RB1
11 11.53 MYC RB1
12 11.48 KIT MYC
13 11.48 MTOR MYC RB1
14 11.44 MYC RB1
15 11.43 MYC RB1
16
Show member pathways
11.38 MTOR MYC
17 11.37 MTOR MYC
18 11.26 MTOR MYC
19 11.21 MYC RB1
20 11.17 MYC RB1
21 11.12 MTOR MYC
22 11.05 MYC RB1
23 10.96 MTOR MYC RB1
24 10.75 MYC RB1
25 10.61 KIT MTOR MYC

GO Terms for Hepatic Angiomyolipoma

Cellular components related to Hepatic Angiomyolipoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 PML body GO:0016605 8.62 MTOR RB1

Biological processes related to Hepatic Angiomyolipoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 regulation of transcription from RNA polymerase II promoter GO:0006357 9.58 KIT MYC RB1
2 cellular response to hypoxia GO:0071456 9.48 MTOR MYC
3 G1/S transition of mitotic cell cycle GO:0000082 9.46 MYC RB1
4 chromatin remodeling GO:0006338 9.43 MYC RB1
5 positive regulation of gene expression GO:0010628 9.43 KIT MTOR MYC
6 visual learning GO:0008542 9.32 KIT MTOR
7 digestive tract development GO:0048565 9.16 KIT RB1
8 positive regulation of translation GO:0045727 9.07 MTOR
9 energy reserve metabolic process GO:0006112 8.96 MTOR MYC
10 cell cycle arrest GO:0007050 8.8 MTOR MYC RB1

Molecular functions related to Hepatic Angiomyolipoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 phosphoprotein binding GO:0051219 8.62 MTOR RB1

Sources for Hepatic Angiomyolipoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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