MCID: HPT006
MIFTS: 41

Hepatic Angiomyolipoma malady

Summaries for Hepatic Angiomyolipoma

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32MalaCards
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MalaCards: Hepatic Angiomyolipoma is related to angiomyolipoma and tuberous sclerosis. An important gene associated with Hepatic Angiomyolipoma is TSC1 (tuberous sclerosis 1), and among its related pathways are LKB1 signaling events and FOXM1 transcription factor network. The compounds orcein and s 100 have been mentioned in the context of this disorder. Affiliated tissues include liver, testes and small intestine, and related mouse phenotypes are homeostasis/metabolism and pigmentation.

Aliases & Classifications for Hepatic Angiomyolipoma

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8Disease Ontology, 60UMLS, 39NCIt
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Aliases & Descriptions:

hepatic angiomyolipoma 8 60


External Ids:

Disease Ontology8 DOID:3317
NCIt39 C27485

Related Diseases for Hepatic Angiomyolipoma

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17GeneCards, 18GeneDecks
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Diseases related to Hepatic Angiomyolipoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 106)
idRelated DiseaseScoreTop Affiliating Genes
1angiomyolipoma31.6TSC1, DES, VIM
2tuberous sclerosis30.6VIM, TSC1
3lymphangioleiomyomatosis30.3DES, TSC1
4osteosarcoma30.0RB1, MYC, CDKN2A
5rhabdomyosarcoma30.0VIM, RB1, DES
6melanoma30.0CDKN2A, MYC, DES, RB1, VIM
7hepatitis11.1
8hepatitis a10.9
9hepatocellular carcinoma10.6
10arteriovenous fistula10.0
11neurofibromatosis10.0
12giant hemangioma10.0
13liver inflammatory pseudotumor10.0
14ulcerative colitis10.0
15disseminated intravascular coagulation10.0
16hemangioma10.0
17pancreatitis10.0
18lipoma10.0DES
19uterine sarcoma10.0DES
20desmoid tumor10.0DES
21infantile myofibromatosis10.0DES
22subependymal giant cell astrocytoma10.0TSC1
23pituitary adenoma10.0RB1
24laryngeal benign neoplasm10.0RB1
25adenocarcinoma in situ10.0CDKN2A
26pituitary tumors10.0RB1
27epidermolysis bullosa simplex10.0DES
28neuroblastoma10.0MYC
29familial adenomatous polyposis10.0MYC
30anaplastic oligodendroglioma10.0CDKN2A
31angiosarcoma10.0VIM
32adenomatoid tumor10.0VIM
33perineurioma10.0VIM
34myoepithelioma10.0VIM
35dedifferentiated liposarcoma10.0RB1, DES
36pneumothorax10.0TSC1
37alveolar rhabdomyosarcoma10.0RB1, DES
38medulloblastoma10.0MYC, DES
39oral cancer10.0RB1, CDKN2A
40laryngeal squamous cell carcinoma10.0RB1, CDKN2A
41li-fraumeni syndrome10.0RB1, CDKN2A
42papilloma10.0CDKN2A, RB1
43meningioma10.0TSC1, VIM
44fibromatosis10.0DES, VIM
45smooth muscle tumor10.0DES, VIM
46rhabdoid tumor10.0VIM, DES
47chordoma10.0DES, VIM
48leiomyoma10.0VIM, DES
49hemangiopericytoma10.0VIM, DES
50chondrosarcoma10.0VIM, DES

Graphical network of the top 20 diseases related to Hepatic Angiomyolipoma:



Diseases related to hepatic angiomyolipoma

Clinical Features for Hepatic Angiomyolipoma

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Drugs & Therapeutics for Hepatic Angiomyolipoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Hepatic Angiomyolipoma

Drug clinical trials:

Search ClinicalTrials for Hepatic Angiomyolipoma

Search NIH Clinical Center for Hepatic Angiomyolipoma

Search CenterWatch for Hepatic Angiomyolipoma

Genetic Tests for Hepatic Angiomyolipoma

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Anatomical Context for Hepatic Angiomyolipoma

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32MalaCards
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MalaCards organs/tissues related to Hepatic Angiomyolipoma:

32
Liver, Testes, Small intestine

Animal Models for Hepatic Angiomyolipoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Hepatic Angiomyolipoma:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.8TSC1, DES
2MP:00011868.4RB1, MYC, CDKN2A
3MP:00020068.4RB1, MYC, CDKN2A, TSC1
4MP:00053708.2TSC1, CDKN2A, MYC, RB1
5MP:00053888.2TSC1, CDKN2A, RB1, VIM
6MP:00053698.0TSC1, RRAD, CDKN2A, MYC, RB1
7MP:00053807.9VIM, RB1, MYC, CDKN2A, TSC1
8MP:00053897.8VIM, RB1, MYC, CDKN2A, TSC1
9MP:00053857.8VIM, RB1, DES, MYC, RRAD, TSC1
10MP:00053867.5VIM, RB1, DES, MYC, CDKN2A, TSC1
11MP:00107687.3VIM, RB1, DES, MYC, CDKN2A, TSC1

Publications for Hepatic Angiomyolipoma

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50PubMed
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Articles related to Hepatic Angiomyolipoma:

(show top 50)    (show all 123)
idTitleAuthorsYear
1
Early venous return in hepatic angiomyolipoma due to an intratumoral structure resembling an arteriovenous fistula. (23679956)
2013
2
Hepatic angiomyolipoma: CT and MR imaging findings with clinical-pathologic comparison. (22996326)
2013
3
Fat-deficient hepatic angiomyolipoma: a radiological challenge. (23701714)
2013
4
Inflammatory angiomyolipoma of the liver: a rare hepatic tumor. (22978636)
2012
5
Hepatic angiomyolipoma: contrast patterns with SonoVue-enhanced real-time gray-scale ultrasonography. (22524813)
2012
6
Sporadic exophytic hepatic angiomyolipoma. (23060385)
2012
7
Angiogenesis and lymphangiogenesis in sporadic hepatic angiomyolipoma. (21665376)
2011
8
Preoperative radiological characterization of hepatic angiomyolipoma using magnetic resonance imaging and contrast-enhanced ultrasonography: a case report. (21943146)
2011
9
Hepatic angiomyolipoma and intramural small intestinal schwannoma: a coincidence or a relationship? (19282295)
2010
10
F-18 FDG PET/CT findings in two patients with hepatic angiomyolipoma with and without intratumoral hemorrhage. (20026966)
2010
11
Hemodynamic characterization of hepatic angiomyolipoma with least amount of fat evaluated by contrast-enhanced magnetic resonance angiography. (19319591)
2010
12
Hepatic angiomyolipoma: a case report. (20518257)
2010
13
Assessment of triple-phase CT findings for the differentiation of fat-deficient hepatic angiomyolipoma from hepatocellular carcinoma in non-cirrhotic liver. (19200676)
2010
14
Hepatic angiomyolipoma: a clinical experience in diagnosis and treatment. (20165978)
2010
15
Hepatic angiomyolipoma: dynamic computed tomography features and clinical correlation. (19610144)
2009
16
Massive hepatic angiomyolipoma in a young woman with tuberous sclerosis complex: significant clinical improvement during tamoxifen treatment. (18436329)
2008
17
The association of pulmonary lymphangioleiomyomatosis with renal and hepatic angiomyolipomas in a prepubertal girl: a previously unreported entity. (15988170)
2007
18
Imprint cytology of epithelioid hepatic angiomyolipoma: mimicry of hepatocellular carcinoma. (17718152)
2007
19
Invasive growth of hepatic angiomyolipoma; a hitherto unreported ominous histological feature. (16722932)
2006
20
Pathological and molecular analysis of sporadic hepatic angiomyolipoma. (16733215)
2006
21
Contrast-enhanced ultrasonography in hepatic angiomyolipoma. (15914690)
2005
22
Aggressive hepatic angiomyolipoma in a child. (15770828)
2005
23
Growth of hepatic angiomyolipoma indicating malignant potential. (15482547)
2004
24
Hepatic angiomyolipoma: report of two cases with emphasis on smear cytomorphology and the use of cell block with immunohistochemical stains. (15452905)
2004
25
Hepatic angiomyolipoma resembling an inflammatory pseudotumor of the liver. A case report. (15648609)
2004
26
Pulmonary lymphangioleiomyomatosis and multiple hepatic angiomyolipomas in a man. (12675767)
2003
27
Hepatic angiomyolipoma: various appearances on two-phase contrast scanning of spiral CT. (11750147)
2002
28
Hepatic angiomyolipoma: report of 8 cases and review of literature. (17585451)
2002
29
Hepatic angiomyolipoma: radiologic and histopathologic correlation. (11847577)
2002
30
Hepatic angiomyolipoma mimicking hepatocellular carcinoma. (12376226)
2002
31
Hepatic angiomyolipoma: a clinicopathologic study of 10 cases. (11780314)
2001
32
Hepatic angiomyolipoma with concomitant hepatocellular carcinomas. (11268978)
2001
33
Trabecular angiomyolipoma mimicking hepatic cell carcinoma. (11033464)
2000
34
US power Doppler of hepatic angiomyolipoma with low fat content. (10879706)
2000
35
Hepatic angiomyolipoma: a rarely described tumor. (11059879)
2000
36
Late recurrence of a hepatic angiomyolipoma. (10833105)
2000
37
Hepatic angiomyolipoma: a clinicopathologic study of 30 cases and delineation of unusual morphologic variants. (9888702)
1999
38
Hepatic angiomyolipoma: report of changing size and internal composition on follow-up examination in two cases. (10096344)
1999
39
Test and teach. Number eighty seven: hepatic angiomyolipoma. (9643493)
1998
40
Spontaneous rupture of a hepatic angiomyolipoma: CT findings and literature review. (9087353)
1997
41
Giant hepatic angiomyolipoma associated with disseminated intravascular coagulation. (9144010)
1997
42
Hepatic angiomyolipoma: value of breath hold 2D flash GD-dynamic imaging with fat saturation. (9690014)
1997
43
Hepatic angiomyolipoma with minimal fat content: MR demonstration. (8897374)
1996
44
Hepatic angiomyolipoma: value of proton (fat/water) chemical shift fast low angle shot (FLASH) MR imaging technique in detecting fatty tissue content. (8544663)
1995
45
Hepatic angiomyolipoma. (7880772)
1994
46
Hepatic angiomyolipoma: is fat in the liver friend or foe? (7820032)
1994
47
Hepatic angiomyolipoma pre-operatively diagnosed by imaging. (8218999)
1993
48
Hepatic angiomyolipoma with striated granules and positivity with melanoma--specific antibody (HMB-45): a report of two cases. (1755113)
1991
49
Hepatic angiomyolipoma in a tuberous sclerosis patient. (2668223)
1989
50
Giant hepatic angiomyolipoma. (2599515)
1989

Genetic Variations for Hepatic Angiomyolipoma

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Expression for genes affiliated with Hepatic Angiomyolipoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hepatic Angiomyolipoma

Search GEO for disease gene expression data for Hepatic Angiomyolipoma.

Pathways for genes affiliated with Hepatic Angiomyolipoma

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37NCBI BioSystems Database, 53Reactome, 29KEGG, 51QIAGEN, 12EMD Millipore
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Pathways related to Hepatic Angiomyolipoma according to GeneCards/GeneDecks:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6TSC1, MYC
29.5RB1, MYC
3
Hide members
9.4DES, VIM
49.4VIM, DES
5
Hide members
9.2CDKN2A, RB1
69.1CDKN2A, MYC
79.1RB1, MYC, TSC1
8
Hide members
9.1TSC1, MYC, RB1
98.9MYC, RB1, VIM
108.9MYC, RB1, VIM
118.7CDKN2A, MYC, RB1
128.7RB1, MYC, CDKN2A
13
Hide members
8.7CDKN2A, MYC, RB1
148.7RB1, MYC, CDKN2A
15
Hide members
8.7CDKN2A, MYC, RB1
16
Hide members
8.7RB1, MYC, CDKN2A
17
Cell cycle Cell cycle (generic schema)
Hide members
8.7RB1, MYC, CDKN2A
188.5CDKN2A, MYC, VIM
19
Hide members
8.3RB1, MYC, CDKN2A, TSC1
208.3TSC1, CDKN2A, MYC, RB1
21
Hide members
7.3VIM, RB1, DES, MYC, CDKN2A, TSC1

Compounds for genes affiliated with Hepatic Angiomyolipoma

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44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience, 2BitterDB, 28IUPHAR
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Compounds related to Hepatic Angiomyolipoma according to GeneCards/GeneDecks:

(show top 50)    (show all 72)
idCompoundScoreTop Affiliating Genes
1orcein449.8VIM, DES
2s 100449.8VIM, DES
3toluidine449.6VIM, DES
4amsacrine44 1110.6VIM, MYC
5tachyplesin i449.5CDKN2A, MYC
64-(methylnitrosamino)-1-(3-pyridyl)-1-butanone449.5CDKN2A, RB1
7reticulin449.5DES, VIM
8mucicarmine449.4VIM, DES
9hpvs449.4RB1, CDKN2A
10n-(4-hydroxyphenyl)retinamide449.3MYC, RB1, VIM
11formaldehyde44 2410.3VIM, RB1, DES
12hyaluronic acid44 2410.2MYC, DES, VIM
13glucose449.1TSC1, RRAD, CDKN2A
14hmba449.1CDKN2A, MYC, RB1
15depsipeptide449.1RB1, MYC, CDKN2A
16paclitaxel44 49 1111.1RB1, MYC, CDKN2A
17guanosine44 11 2411.0VIM, CDKN2A, TSC1
18hematoxylin449.0CDKN2A, DES, VIM
19paraffin449.0TSC1, MYC, DES, VIM
20camptothecin44 59 1111.0CDKN2A, MYC, RB1
21azathioprine44 49 2 1112.0CDKN2A, DES, VIM
22glycogen44 249.9TSC1, MYC, DES, VIM
23thymidylate448.9VIM, RB1, CDKN2A
24rapamycin448.9VIM, RB1, MYC, TSC1
25bromodeoxyuridine448.9VIM, RB1, DES, MYC
2612-o-tetradecanoylphorbol 13-acetate448.9MYC, DES, RB1, VIM
27dmso448.8MYC, RB1, VIM
28folate448.7VIM, MYC, CDKN2A
295-aza-2deoxycytidine448.6VIM, MYC, CDKN2A
30biotin44 11 2410.6CDKN2A, DES, RB1, VIM
31roscovitine448.5VIM, RB1, MYC, CDKN2A
32cytarabine44 49 1110.5VIM, RB1, MYC, CDKN2A
33vincristine44 49 1110.5VIM, RB1, MYC, CDKN2A
34agar448.5VIM, RB1, MYC, CDKN2A
35cyclic amp44 249.5VIM, RB1, DES, CDKN2A
36progesterone44 59 28 11 2412.5VIM, RB1, DES, CDKN2A
37h2o2448.4VIM, RB1, DES, CDKN2A
38genistein44 28 59 2 11 2413.4VIM, RB1, MYC, CDKN2A
39testosterone44 59 11 2411.4CDKN2A, DES, RB1, VIM
40leucine448.4CDKN2A, MYC, RB1, VIM
41adriamycin448.1VIM, RB1, DES, MYC, CDKN2A
42doxorubicin44 49 1110.1VIM, RB1, DES, MYC, CDKN2A
43actinomycin d448.1CDKN2A, MYC, DES, RB1, VIM
44dexamethasone44 49 28 1111.1CDKN2A, MYC, RB1, VIM
45estrogen448.0VIM, RB1, DES, MYC, CDKN2A
46retinoic acid44 249.0VIM, RB1, DES, MYC, CDKN2A
47threonine447.8RB1, DES, MYC, CDKN2A, RRAD, TSC1
48oligonucleotide447.8VIM, RB1, MYC, CDKN2A
49vegf447.7VIM, RB1, DES, MYC, CDKN2A, TSC1
50serine447.2VIM, RB1, DES, MYC, CDKN2A, RRAD

GO Terms for genes affiliated with Hepatic Angiomyolipoma

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16Gene Ontology
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Cellular components related to Hepatic Angiomyolipoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein complexGO:0432348.8TSC1, CDKN2A, MYC

Biological processes related to Hepatic Angiomyolipoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:0300499.4DES, VIM
2cell cycle checkpointGO:0000758.9CDKN2A, RB1
3cell cycle arrestGO:0070508.2TSC1, CDKN2A, MYC, RB1

Molecular functions related to Hepatic Angiomyolipoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transcription factor bindingGO:0081348.7CDKN2A, MYC, RB1
2protein bindingGO:0055156.4TSC1, VIM, RB1, DES, MYC, CDKN2A

Products for genes affiliated with Hepatic Angiomyolipoma

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  • Antibodies
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Sources for Hepatic Angiomyolipoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet