MCID: HPT006
MIFTS: 34

Hepatic Angiomyolipoma

Categories: Cancer diseases

Aliases & Classifications for Hepatic Angiomyolipoma

MalaCards integrated aliases for Hepatic Angiomyolipoma:

Name: Hepatic Angiomyolipoma 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:3317
NCIt 46 C27485
UMLS 69 C1333962

Summaries for Hepatic Angiomyolipoma

MalaCards based summary : Hepatic Angiomyolipoma is related to angiomyolipoma and hepatocellular carcinoma. An important gene associated with Hepatic Angiomyolipoma is AFP (Alpha Fetoprotein), and among its related pathways/superpathways are Endometrial cancer and PI3K-Akt signaling pathway. Affiliated tissues include liver, testes and small intestine, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Hepatic Angiomyolipoma

Diseases related to Hepatic Angiomyolipoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Related Disease Score Top Affiliating Genes
1 angiomyolipoma 30.9 KIT MTOR
2 hepatocellular carcinoma 29.4 AFP MTOR MYC RB1
3 hepatitis 10.8
4 malignant biphasic mesothelioma 10.2 AFP MYC
5 tuberous sclerosis 10.2
6 hemimegalencephaly 10.1 MTOR MYC
7 germ cell and embryonal cancer 10.1 AFP MYC
8 suppressor of tumorigenicity 3 10.0 MYC RB1
9 mixed germ cell tumor 10.0 AFP KIT
10 tuberous sclerosis 1 10.0
11 intratubular embryonal carcinoma 10.0 AFP KIT
12 endometrial small cell carcinoma 10.0 AFP KIT
13 rete testis adenocarcinoma 10.0 AFP KIT
14 testicular infarct 9.9 AFP KIT
15 mediastinal cancer 9.9 AFP KIT
16 rete testis neoplasm 9.9 AFP KIT
17 extragonadal seminoma 9.9 AFP KIT
18 dysgerminoma of ovary 9.9 AFP KIT
19 retinal cancer 9.9 MYC RB1
20 kidney benign neoplasm 9.9 KIT MTOR
21 lymphangioleiomyomatosis 9.9
22 hemangioma 9.9
23 sensory system cancer 9.9 MYC RB1
24 brain germinoma 9.9 AFP KIT
25 ocular cancer 9.8 MYC RB1
26 fibrosarcoma of bone 9.8 KIT MYC
27 juvenile nasopharyngeal angiofibroma 9.8 KIT MYC
28 neurofibromatosis, type iv, of riccardi 9.7
29 congenital heart defects, hamartomas of tongue, and polysyndactyly 9.7
30 arteriovenous fistula 9.7
31 ulcerative colitis 9.7
32 colitis 9.7
33 disseminated intravascular coagulation 9.7
34 melanoma 9.7
35 rhabdomyosarcoma 9.7
36 cavernous hemangioma 9.7
37 pancreatitis 9.7
38 giant hemangioma 9.7
39 testicular germ cell tumor 9.7 AFP KIT
40 angiosarcoma 9.7 KIT MYC
41 teratoma 9.7 AFP KIT
42 glioblastoma multiforme 9.7 MTOR MYC RB1
43 nervous system cancer 9.7 MYC RB1
44 glioblastoma 9.7 MTOR MYC RB1
45 gastrointestinal system cancer 9.6 AFP KIT MYC
46 cell type cancer 9.6 AFP KIT MYC
47 ewing's family of tumors 9.5 KIT MTOR RB1
48 leukemia, acute myeloid 9.5 KIT MTOR MYC
49 seminoma 9.4 AFP KIT
50 small cell cancer of the lung 9.4 KIT MYC RB1

Graphical network of the top 20 diseases related to Hepatic Angiomyolipoma:



Diseases related to Hepatic Angiomyolipoma

Symptoms & Phenotypes for Hepatic Angiomyolipoma

GenomeRNAi Phenotypes related to Hepatic Angiomyolipoma according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.28 MTOR
2 Decreased viability GR00221-A-1 9.28 KIT MTOR MYC
3 Decreased viability GR00221-A-3 9.28 MYC
4 Decreased viability GR00221-A-4 9.28 MTOR
5 Decreased viability GR00301-A 9.28 KIT
6 Decreased viability GR00342-S-1 9.28 MTOR
7 Decreased viability GR00342-S-2 9.28 MTOR

MGI Mouse Phenotypes related to Hepatic Angiomyolipoma:

43 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.95 RB1 KIT MTOR AFP MYC CRBN
2 endocrine/exocrine gland MP:0005379 9.91 MTOR AFP MYC CRBN RB1 KIT
3 homeostasis/metabolism MP:0005376 9.88 KIT RB1 MTOR AFP MYC CRBN
4 cardiovascular system MP:0005385 9.85 KIT RB1 MTOR MYC CRBN
5 adipose tissue MP:0005375 9.8 RB1 MTOR MYC CRBN
6 liver/biliary system MP:0005370 9.77 RB1 KIT AFP MYC CRBN
7 muscle MP:0005369 9.62 KIT RB1 MTOR MYC
8 neoplasm MP:0002006 9.56 KIT RB1 AFP MYC
9 no phenotypic analysis MP:0003012 9.46 KIT RB1 MTOR MYC
10 pigmentation MP:0001186 9.13 KIT RB1 MYC
11 reproductive system MP:0005389 9.02 RB1 KIT AFP MYC CRBN

Drugs & Therapeutics for Hepatic Angiomyolipoma

Search Clinical Trials , NIH Clinical Center for Hepatic Angiomyolipoma

Genetic Tests for Hepatic Angiomyolipoma

Anatomical Context for Hepatic Angiomyolipoma

MalaCards organs/tissues related to Hepatic Angiomyolipoma:

38
Liver, Testes, Small Intestine

Publications for Hepatic Angiomyolipoma

Articles related to Hepatic Angiomyolipoma:

(show top 50) (show all 142)
# Title Authors Year
1
Hepatic angiomyolipoma detected using computed tomography. ( 29392859 )
2018
2
Hepatic angiomyolipoma presenting as an arterially enhancing liver lesion. ( 29392818 )
2018
3
Hepatic angiomyolipomas may overexpress TFE3, but have no relevant genetic alterations. ( 27865795 )
2017
4
Primary hepatic angiomyolipoma: immunohistochemistry and electron microscopic observations: a case report. ( 28327196 )
2017
5
Management of hepatic angiomyolipoma: A systematic review. ( 28177188 )
2017
6
The Histopathological Features and CT/MRI Imaging Performances in Hepatic Angiomyolipoma Patients. ( 28809731 )
2017
7
Clinico-pathological correlation of hepatic angiomyolipoma: a series of 23 resection cases. ( 28122404 )
2017
8
A case of ruptured hepatic angiomyolipoma in a young male. ( 28449573 )
2017
9
Selecting a suitable surgical treatment for hepatic angiomyolipoma: a retrospective analysis of 92 cases. ( 29241297 )
2017
10
Hepatic Angiomyolipoma Staining in the Post-vascular Phase of Contrast-enhanced Ultrasound Due to the Presence of Macrophages. ( 29279500 )
2017
11
Pulmonary Lymphangiomyomatosis Associated with Renal and Hepatic Angiomyolipoma Mass in a Patient with Tuberous Sclerosis Complex. ( 29237943 )
2017
12
Hepatic Angiomyolipoma Versus Hepatocellular Carcinoma in the Noncirrhotic Liver on Gadoxetic Acid-Enhanced MRI: A Diagnostic Challenge. ( 27248975 )
2016
13
Comparison of CT and contrast-enhanced ultrasound findings in hepatic angiomyolipoma with pathological correlations. ( 26867906 )
2016
14
CD68-Positive Cells in Hepatic Angiomyolipoma. ( 28030864 )
2016
15
Hepatic angiomyolipoma: differential diagnosis from other liver tumors in a special reference to vascular imaging - importance of early drainage vein. ( 26943379 )
2015
16
Liver transplantation for recurrent posthepatectomy malignant hepatic angiomyolipoma: A case report. ( 25834347 )
2015
17
Hepatocellular carcinoma with concomitant hepatic angiomyolipoma and cavernous hemangioma in one patient. ( 25805953 )
2015
18
Hepatic angiomyolipoma with special attention to radiologic imaging. ( 26366342 )
2015
19
Visualizing Central Vessels of Hepatic Angiomyolipoma Devoid of Fat Using a 2D Multi-Breath-Hold Susceptibility-Weighted Imaging. ( 26114004 )
2015
20
A rare case of xanthogranulomatous pyelonepheritis with hepatic angiomyolipoma. ( 26617933 )
2015
21
Hepatic angiomyolipoma mimicking hepatocellular carcinoma: magnetic resonance imaging and clinical pathological characteristics in 9 cases. ( 25803731 )
2015
22
Diagnosis of Hepatic Angiomyolipoma by Combination of Baseline and Contrast-Enhanced Ultrasound--A Prospective Study in Non-Cirrhotic Patients. ( 26147859 )
2015
23
Hepatic angiomyolipoma mimicking hepatocellular carcinoma: magnetic resonance imaging and clinical pathological characteristics in 9 cases. ( 25526436 )
2014
24
Comparison of MRI features for the differentiation of hepatic angiomyolipoma from fat-containing hepatocellular carcinoma. ( 24389893 )
2014
25
Hepatic angiomyolipoma: what management? ( 25073214 )
2014
26
Myomatous hepatic angiomyolipoma: imaging findings in 14 cases with radiological-pathological correlation and review of the literature. ( 24670055 )
2014
27
Spontaneous rupture of a hepatic angiomyolipoma: Report of a case. ( 26184024 )
2014
28
Hepatic angiomyolipoma growing to cause epigastric discomfort: a case report. ( 26185889 )
2014
29
Alterations of the mTOR Pathway in Hepatic Angiomyolipoma with Emphasis on the Epithelioid Variant and Loss of Heterogeneity of the TSC1/TSC2 Genes. ( 25234729 )
2014
30
Hepatic angiomyolipoma: CT and MR imaging findings with clinical-pathologic comparison. ( 22996326 )
2013
31
Is surgery necessary for patients with hepatic angiomyolipoma? Retrospective analysis from eight Chinese cases. ( 23731017 )
2013
32
Hepatic angiomyolipoma: a case report with diagnostic challenge. ( 24152510 )
2013
33
Hepatic angiomyolipoma and neurofibromatosis type 2: a novel association. ( 24314304 )
2013
34
Hepatic angiomyolipoma: clinical, imaging and pathological features in 178 cases. ( 23292871 )
2013
35
Large hepatic angiomyolipoma. ( 23433965 )
2013
36
Early venous return in hepatic angiomyolipoma due to an intratumoral structure resembling an arteriovenous fistula. ( 23679956 )
2013
37
Fat-deficient hepatic angiomyolipoma: a radiological challenge. ( 23701714 )
2013
38
Immunohistochemical character of hepatic angiomyolipoma: for its management. ( 23864864 )
2013
39
Hepatic angiomyolipoma: a series of six cases with emphasis on pathological-radiological correlations and unusual variants diagnosed by core needle biopsy. ( 22949933 )
2012
40
Hepatic angiomyolipoma with minimal fat, mimicking hepatocellular carcinoma. ( 23091816 )
2012
41
Sporadic exophytic hepatic angiomyolipoma. ( 23060385 )
2012
42
Hepatic angiomyolipoma: contrast patterns with SonoVue-enhanced real-time gray-scale ultrasonography. ( 22524813 )
2012
43
Hepatic angiomyolipoma: diagnostic findings and management. ( 23320180 )
2012
44
Diagnosis and treatment of hepatic angiomyolipoma. ( 24570900 )
2012
45
Characteristics and treatment strategy of hepatic angiomyolipoma: a series of 94 patients collected from four institutions. ( 21451800 )
2011
46
Liver transplantation for giant hepatic angiomyolipoma. ( 21462294 )
2011
47
Diagnostic difficulties and treatment strategy of hepatic angiomyolipoma. ( 22464831 )
2011
48
Preoperative radiological characterization of hepatic angiomyolipoma using magnetic resonance imaging and contrast-enhanced ultrasonography: a case report. ( 21943146 )
2011
49
Angiogenesis and lymphangiogenesis in sporadic hepatic angiomyolipoma. ( 21665376 )
2011
50
Development of hepatic angiomyolipoma accompanied with focal nodular hyperplasia long after treatment of pelvic rhabdomyosarcoma. ( 21683235 )
2011

Variations for Hepatic Angiomyolipoma

Expression for Hepatic Angiomyolipoma

Search GEO for disease gene expression data for Hepatic Angiomyolipoma.

Pathways for Hepatic Angiomyolipoma

Pathways related to Hepatic Angiomyolipoma according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.68 KIT MTOR MYC RB1
2
Show member pathways
12.58 KIT MTOR MYC RB1
3 12.35 KIT MTOR MYC RB1
4
Show member pathways
12.24 MTOR MYC RB1
5
Show member pathways
12.22 KIT MTOR MYC RB1
6
Show member pathways
11.87 MTOR MYC RB1
7 11.81 MTOR MYC RB1
8 11.77 MTOR MYC RB1
9
Show member pathways
11.73 MTOR MYC RB1
10 11.56 MYC RB1
11 11.5 KIT MYC
12 11.47 MYC RB1
13 11.46 MYC RB1
14
Show member pathways
11.42 MTOR MYC
15 11.4 MTOR MYC
16 11.38 MTOR MYC RB1
17 11.3 MTOR MYC
18 11.25 MYC RB1
19 11.22 MYC RB1
20 11.16 MTOR MYC
21 11.09 MYC RB1
22 10.96 MTOR MYC RB1
23 10.82 MYC RB1
24 10.61 KIT MTOR MYC

GO Terms for Hepatic Angiomyolipoma

Biological processes related to Hepatic Angiomyolipoma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.58 KIT MTOR MYC
2 regulation of mitotic cell cycle GO:0007346 9.49 MYC RB1
3 regulation of cell growth GO:0001558 9.48 MTOR RB1
4 positive regulation of translation GO:0045727 9.46 MTOR MYC
5 positive regulation of smooth muscle cell proliferation GO:0048661 9.43 MTOR MYC
6 visual learning GO:0008542 9.37 KIT MTOR
7 ovarian follicle development GO:0001541 9.32 KIT MYC
8 digestive tract development GO:0048565 9.26 KIT RB1
9 energy reserve metabolic process GO:0006112 9.16 MTOR MYC
10 cell cycle arrest GO:0007050 9.13 MTOR MYC RB1
11 positive regulation of glial cell proliferation GO:0060252 8.62 MTOR MYC

Molecular functions related to Hepatic Angiomyolipoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphoprotein binding GO:0051219 8.62 MTOR RB1

Sources for Hepatic Angiomyolipoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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