Aliases & Classifications for Hepatic Angiomyolipoma

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Aliases & Descriptions for Hepatic Angiomyolipoma:

Name: Hepatic Angiomyolipoma 8 61


External Ids:

Disease Ontology8 DOID:3317
NCIt39 C27485

Summaries for Hepatic Angiomyolipoma

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MalaCards based summary: Hepatic Angiomyolipoma is related to angiomyolipoma and tuberous sclerosis. An important gene associated with Hepatic Angiomyolipoma is DES (desmin), and among its related pathways are Cytoplasmic microtubules and Striated Muscle Contraction. The compounds orcein and s 100 have been mentioned in the context of this disorder. Affiliated tissues include liver, small intestine and testes, and related mouse phenotypes are pigmentation and respiratory system.

Related Diseases for Hepatic Angiomyolipoma

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Diseases related to Hepatic Angiomyolipoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 93)
idRelated DiseaseScoreTop Affiliating Genes
1angiomyolipoma31.8DES, VIM, TSC1
2tuberous sclerosis31.0VIM, TSC1
3lymphangioleiomyomatosis30.8DES, TSC1
4hepatocellular carcinoma30.2CDKN2A, RB1, MYC
5rhabdomyosarcoma30.0DES, VIM, RB1
6melanoma29.3CDKN2A, RB1, MYC, VIM, DES
7hepatitis11.1
8infantile myofibromatosis10.5DES
9subependymal giant cell astrocytoma10.5TSC1
10adenomatoid tumor10.4VIM
11epithelioid leiomyosarcoma10.3DES, VIM
12mesenchymal chondrosarcoma10.3DES, VIM
13pseudosarcomatous fibromatosis10.3DES, VIM
14spindle cell carcinoma10.3VIM, DES
15spindle cell sarcoma10.3DES, VIM
16alveolar soft-part sarcoma10.3DES, VIM
17sertoli cell tumor10.3VIM, DES
18granular cell tumor10.3DES, VIM
19dermatofibrosarcoma protuberans10.3DES, VIM
20fibrous histiocytoma10.3DES, VIM
21endometrial stromal sarcoma10.3DES, VIM
22hemangioma10.3
23rhabdoid tumor10.3DES, VIM
24hemangiopericytoma10.2DES, VIM
25sex cord-gonadal stromal tumor10.2DES, VIM
26glomus tumor10.2DES, VIM
27malignant mixed mullerian tumor10.2DES, VIM
28fibromatosis10.2VIM, DES
29chordoma10.2DES, VIM
30smooth muscle tumor10.2DES, VIM
31abrikosov's tumor10.2DES, VIM
32giant cell tumor10.2DES, VIM
33malignant fibroxanthoma10.2DES, VIM
34pleomorphic adenoma10.2DES, VIM
35sarcoma, synovial10.2VIM, DES
36gastrointestinal stromal tumor10.2DES, VIM
37neurilemmoma10.2VIM, DES
38oxyphilic adenoma10.2VIM, TSC1
39malignant peripheral nerve sheath tumor10.2VIM, CDKN2A
40polycystic kidney disease, autosomal dominant10.1TSC1, MYC
41leiomyoma10.1VIM, DES
42dedifferentiated liposarcoma10.1DES, RB1
43precursor b-cell acute lymphoblastic leukemia10.1CDKN2A, MYC
44rhabdomyosarcoma 2, alveolar10.1DES, RB1
45neurofibromatosis, type 210.1
46arteriovenous fistula10.1
47ulcerative colitis10.1
48neurofibromatosis10.1
49giant hemangioma10.1
50cavernous hemangioma10.1

Graphical network of the top 20 diseases related to Hepatic Angiomyolipoma:



Diseases related to hepatic angiomyolipoma

Symptoms for Hepatic Angiomyolipoma

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Drugs & Therapeutics for Hepatic Angiomyolipoma

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Drug clinical trials:

Search ClinicalTrials for Hepatic Angiomyolipoma

Search NIH Clinical Center for Hepatic Angiomyolipoma

Genetic Tests for Hepatic Angiomyolipoma

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Anatomical Context for Hepatic Angiomyolipoma

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MalaCards organs/tissues related to Hepatic Angiomyolipoma:

31
Liver, Small intestine, Testes

Animal Models for Hepatic Angiomyolipoma or affiliated genes

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MGI Mouse Phenotypes related to Hepatic Angiomyolipoma:

35 (show all 17)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011868.6MYC, RB1, CDKN2A
2MP:00053888.3VIM, TSC1, RB1, CDKN2A
3MP:00020068.3CDKN2A, TSC1, MYC, RB1
4MP:00053708.3CDKN2A, TSC1, MYC, RB1
5MP:00107718.1CDKN2A, RB1, TSC1, MYC
6MP:00053798.0MYC, TSC1, RB1, CDKN2A
7MP:00053857.9VIM, MYC, TSC1, RB1, DES
8MP:00053807.8VIM, CDKN2A, RB1, TSC1, MYC
9MP:00053897.8TSC1, VIM, MYC, CDKN2A, RB1
10MP:00053907.8CDKN2A, RB1, TSC1, MYC
11MP:00053847.7RB1, CDKN2A, MYC, VIM, TSC1
12MP:00036317.6VIM, TSC1, MYC, RB1, CDKN2A
13MP:00053787.5RB1, CDKN2A, TSC1, MYC, VIM
14MP:00053697.4CDKN2A, RB1, TSC1, MYC, VIM, DES
15MP:00053867.4CDKN2A, VIM, MYC, TSC1, RB1, DES
16MP:00053767.4DES, TSC1, RB1, CDKN2A, MYC, VIM
17MP:00107687.4MYC, CDKN2A, VIM, TSC1, RB1, DES

Publications for Hepatic Angiomyolipoma

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Articles related to Hepatic Angiomyolipoma:

(show top 50)    (show all 120)
idTitleAuthorsYear
1
Liver transplantation for recurrent posthepatectomy malignant hepatic angiomyolipoma: A case report. (25834347)
2015
2
Myomatous hepatic angiomyolipoma: imaging findings in 14 cases with radiological-pathological correlation and review of the literature. (24670055)
2014
3
Hepatic angiomyolipoma: what management? (25073214)
2014
4
Comparison of MRI features for the differentiation of hepatic angiomyolipoma from fat-containing hepatocellular carcinoma. (24389893)
2014
5
Alterations of the mTOR Pathway in Hepatic Angiomyolipoma with Emphasis on the Epithelioid Variant and Loss of Heterogeneity of the TSC1/TSC2 Genes. (25234729)
2014
6
Immunohistochemical character of hepatic angiomyolipoma: for its management. (23864864)
2013
7
Early venous return in hepatic angiomyolipoma due to an intratumoral structure resembling an arteriovenous fistula. (23679956)
2013
8
Hepatic angiomyolipoma and neurofibromatosis type 2: a novel association. (24314304)
2013
9
Hepatic angiomyolipoma: CT and MR imaging findings with clinical-pathologic comparison. (22996326)
2013
10
Hepatic angiomyolipoma with minimal fat, mimicking hepatocellular carcinoma. (23091816)
2012
11
Hepatic angiomyolipoma with a giant hemangioma. (22041879)
2011
12
Characteristics and treatment strategy of hepatic angiomyolipoma: a series of 94 patients collected from four institutions. (21451800)
2011
13
Development of hepatic angiomyolipoma accompanied with focal nodular hyperplasia long after treatment of pelvic rhabdomyosarcoma. (21683235)
2011
14
Diagnostic difficulties and treatment strategy of hepatic angiomyolipoma. (22464831)
2011
15
Liver transplantation for giant hepatic angiomyolipoma. (21462294)
2011
16
Hepatic angiomyolipoma and intramural small intestinal schwannoma: a coincidence or a relationship? (19282295)
2010
17
F-18 FDG PET/CT findings in two patients with hepatic angiomyolipoma with and without intratumoral hemorrhage. (20026966)
2010
18
Hemodynamic characterization of hepatic angiomyolipoma with least amount of fat evaluated by contrast-enhanced magnetic resonance angiography. (19319591)
2010
19
Hepatic angiomyolipoma: a case report. (20518257)
2010
20
Assessment of triple-phase CT findings for the differentiation of fat-deficient hepatic angiomyolipoma from hepatocellular carcinoma in non-cirrhotic liver. (19200676)
2010
21
Hepatic angiomyolipoma: dynamic computed tomography features and clinical correlation. (19610144)
2009
22
Wunderlich's syndrome with hepatic angiomyolipoma in tuberous sclerosis. (18626151)
2008
23
Clinical features of hepatic angiomyolipoma. (18522883)
2008
24
Massive hepatic angiomyolipoma in a young woman with tuberous sclerosis complex: significant clinical improvement during tamoxifen treatment. (18436329)
2008
25
Hepatic angiomyolipoma. (18834230)
2008
26
Management of hepatic angiomyolipoma. (17436129)
2007
27
Invasive growth of hepatic angiomyolipoma; a hitherto unreported ominous histological feature. (16722932)
2006
28
Hepatic angiomyolipoma with trace amounts of fat: a case report and literature review. (17071805)
2006
29
Hepatic angiomyolipoma: identification of an efferent vessel to be hepatic vein by contrast-enhanced harmonic ultrasound. (16177023)
2005
30
Hepatic angiomyolipoma demonstrating similar imaging characteristics as hepatocellular carcinoma: one case report. (16463691)
2005
31
Contrast-enhanced ultrasonography in hepatic angiomyolipoma. (15914690)
2005
32
Hepatic angiomyolipoma and hepatic stellate cells share a similar gene expression profile. (15891994)
2005
33
Growth of hepatic angiomyolipoma indicating malignant potential. (15482547)
2004
34
A solitary hepatic lesion: MRI-pathological correlation of an hepatic angiomyolipoma (2004:4b). (15221270)
2004
35
Hepatic angiomyolipoma. (12773992)
2003
36
Hepatic angiomyolipoma associated with splenic hamartoma. (11929179)
2002
37
Common and epithelioid variants of hepatic angiomyolipoma exhibit clonal growth and share a distinctive immunophenotype. (10915726)
2000
38
Hepatic angiomyolipoma-misdiagnosis as hepatocellular carcinoma: A report of 14 cases. (11819659)
2000
39
US power Doppler of hepatic angiomyolipoma with low fat content. (10879706)
2000
40
Hepatic angiomyolipoma: a clinicopathologic study of 30 cases and delineation of unusual morphologic variants. (9888702)
1999
41
Hepatic angiomyolipoma with 'oncocyte-like' features. (9870158)
1998
42
Spontaneous rupture of a hepatic angiomyolipoma: CT findings and literature review. (9087353)
1997
43
Hepatic angiomyolipoma: two case reports of caudate-based lesions and review of the literature. (9377758)
1997
44
Hepatic angiomyolipoma: a report of two cases. (8820041)
1996
45
Hepatic angiomyolipoma with minimal fat content: MR demonstration. (8897374)
1996
46
Hepatic angiomyolipoma. (7820028)
1994
47
Hepatic angiomyolipoma pre-operatively diagnosed by imaging. (8218999)
1993
48
Hepatic angiomyolipomas with a deceptive trabecular pattern and HMB-45 reactivity. (1334941)
1992
49
Hepatic angiomyolipoma in a tuberous sclerosis patient. (2401620)
1990
50
Hepatic angiomyolipoma in a tuberous sclerosis patient. (2668223)
1989

Variations for Hepatic Angiomyolipoma

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Expression for genes affiliated with Hepatic Angiomyolipoma

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Search GEO for disease gene expression data for Hepatic Angiomyolipoma.

Pathways for genes affiliated with Hepatic Angiomyolipoma

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Pathways related to Hepatic Angiomyolipoma according to GeneCards Suite gene sharing:

(show all 36)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5VIM, DES
2
Show member pathways
Signaling by Aurora kinases36
Aurora C signaling36
9.5VIM, DES
39.4TSC1, MYC
4
Show member pathways
Development IGF RI signaling
Immune response IL 4 signaling pathway59
Signal transduction AKT signaling59
9.4MYC, TSC1
59.4TSC1, MYC
6
Show member pathways
9.3CDKN2A, MYC
79.1CDKN2A, RB1
8
Show member pathways
9.1CDKN2A, RB1
99.1RB1, CDKN2A
10
Show member pathways
FAS pathway and Stress induction of HSP regulation36
Apoptosis and survival FAS signaling cascades59
Caspase cascade in apoptosis36
9.1RB1, VIM
119.0RB1, MYC
12
Show member pathways
Cell cycle ESR1 regulation of G1 S transition59
Immune response MIF JAB1 signaling59
Cell cycle Cell cycle generic schema 59
9.0RB1, MYC
139.0RB1, MYC
149.0RB1, MYC
159.0RB1, MYC
169.0MYC, RB1
178.8VIM, MYC, CDKN2A
188.6MYC, RB1, TSC1
19
Show member pathways
Prostate Cancer36
Integrated Cancer pathway36
Steroid Biosynthesis36
8.6TSC1, MYC, RB1
20
Show member pathways
8.5RB1, MYC, CDKN2A
218.5RB1, MYC, CDKN2A
22
Show member pathways
8.5MYC, RB1, CDKN2A
238.5MYC, CDKN2A, RB1
24
Show member pathways
8.5RB1, MYC, CDKN2A
25
Show member pathways
Cell cycle36
8.5CDKN2A, RB1, MYC
26
Show member pathways
DNA damage response36
8.5CDKN2A, RB1, MYC
278.5CDKN2A, RB1, MYC
28
Show member pathways
8.5CDKN2A, MYC, RB1
29
Show member pathways
8.5RB1, CDKN2A, MYC
308.5VIM, MYC, RB1
318.5VIM, MYC, RB1
32
Show member pathways
Proteasome Degradation36
Immune response Antigen presentation by MHC class I59
8.5MYC, VIM, RB1
33
Show member pathways
Signaling Pathways in Glioblastoma36
8.1RB1, MYC, TSC1, CDKN2A
348.1MYC, RB1, CDKN2A, TSC1
35
Show member pathways
7.1CDKN2A, TSC1, RB1, VIM, MYC, DES

Compounds for genes affiliated with Hepatic Angiomyolipoma

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Compounds related to Hepatic Angiomyolipoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 101)
idCompoundScoreTop Affiliating Genes
1orcein449.9VIM, DES
2s 100449.8VIM, DES
3tachyplesin i449.7MYC, CDKN2A
4hematoxylin449.4VIM, DES, CDKN2A
5azathioprine44 1 50 1112.4CDKN2A, DES, VIM
64-(methylnitrosamino)-1-(3-pyridyl)-1-butanone449.4RB1, CDKN2A
7guanosine44 24 1111.3CDKN2A, TSC1, VIM
8toluidine449.2VIM, DES
9amsacrine44 1110.2VIM, MYC
10hyaluronic acid44 2410.2DES, VIM, MYC
11hpvs449.1RB1, CDKN2A
12folate449.0CDKN2A, VIM, MYC
13formaldehyde44 2410.0DES, RB1, VIM
145-aza-2deoxycytidine449.0MYC, VIM, CDKN2A
15thymidylate448.9VIM, CDKN2A, RB1
16hmba448.9CDKN2A, MYC, RB1
17depsipeptide448.9MYC, RB1, CDKN2A
18n-(4-hydroxyphenyl)retinamide448.9RB1, MYC, VIM
19glycogen44 249.8MYC, TSC1, DES, VIM
20camptothecin44 60 1110.8RB1, MYC, CDKN2A
21biotin44 24 1110.6RB1, VIM, DES, CDKN2A
22dmso448.6MYC, RB1, VIM
23cyclic amp44 249.5RB1, VIM, DES, CDKN2A
24bromodeoxyuridine448.5VIM, RB1, MYC, DES
25progesterone44 28 60 24 1112.5DES, VIM, CDKN2A, RB1
2612-o-tetradecanoylphorbol 13-acetate448.5DES, VIM, MYC, RB1
27h2o2448.5VIM, CDKN2A, RB1, DES
28vitamin a44 24 1110.5VIM, MYC, RB1
29testosterone44 60 24 1111.5CDKN2A, VIM, RB1, DES
30rapamycin448.4RB1, TSC1, MYC, VIM
31roscovitine448.4RB1, CDKN2A, MYC, VIM
32vincristine44 50 1110.4CDKN2A, RB1, MYC, VIM
33cytarabine44 50 1110.4RB1, VIM, CDKN2A, MYC
34alanine448.4VIM, TSC1, MYC, CDKN2A
35agar448.4CDKN2A, RB1, MYC, VIM
36butyrate448.4MYC, VIM, RB1, CDKN2A
37paclitaxel44 50 1110.4VIM, MYC, RB1, CDKN2A
38genistein44 28 60 1 24 1113.4VIM, MYC, RB1, CDKN2A
39leucine448.3CDKN2A, RB1, MYC, VIM
40oligonucleotide448.2VIM, RB1, MYC, CDKN2A
41dexamethasone44 50 28 1111.2VIM, CDKN2A, MYC, RB1
42threonine448.1CDKN2A, TSC1, DES, MYC, RB1
43adriamycin448.0MYC, VIM, RB1, DES, CDKN2A
44doxorubicin44 50 1110.0DES, VIM, MYC, RB1, CDKN2A
45actinomycin d448.0VIM, MYC, DES, CDKN2A, RB1
46estrogen448.0VIM, RB1, DES, CDKN2A, MYC
47retinoic acid44 249.0DES, VIM, CDKN2A, MYC, RB1
48paraffin447.6MYC, CDKN2A, RB1, TSC1, VIM, DES
49vegf447.6CDKN2A, VIM, MYC, TSC1, RB1, DES
50serine447.5CDKN2A, RB1, MYC, VIM, DES, TSC1

GO Terms for genes affiliated with Hepatic Angiomyolipoma

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Cellular components related to Hepatic Angiomyolipoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:00058829.5VIM, DES
2protein complexGO:00432348.6CDKN2A, TSC1, MYC

Biological processes related to Hepatic Angiomyolipoma according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:00300499.7VIM, DES
2cell cycle checkpointGO:00000759.3RB1, CDKN2A
3negative regulation of protein kinase activityGO:00064699.2CDKN2A, RB1
4protein stabilizationGO:00508219.2TSC1, CDKN2A
5chromatin remodelingGO:00063389.0RB1, MYC
6Ras protein signal transductionGO:00072659.0CDKN2A, RB1
7positive regulation of transcription, DNA-templatedGO:00458938.6MYC, RB1, CDKN2A
8positive regulation of transcription from RNA polymerase II promoterGO:00459448.5CDKN2A, RB1, MYC
9cell cycle arrestGO:00070508.3CDKN2A, RB1, TSC1, MYC

Molecular functions related to Hepatic Angiomyolipoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:000520010.1DES
2transcription factor bindingGO:00081348.5CDKN2A, RB1, MYC
3identical protein bindingGO:00428028.4RB1, VIM, DES
4protein bindingGO:00055157.0DES, VIM, MYC, TSC1, RB1, CDKN2A

Sources for Hepatic Angiomyolipoma

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet