MCID: HPT006
MIFTS: 37

Hepatic Angiomyolipoma malady

Summaries for Hepatic Angiomyolipoma

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33MalaCards
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MalaCards: Hepatic Angiomyolipoma is related to angiomyolipoma and tuberous sclerosis. An important gene associated with Hepatic Angiomyolipoma is TSC1 (tuberous sclerosis 1), and among its related pathways are LKB1 signaling events and FOXM1 transcription factor network. The compounds orcein and s 100 have been mentioned in the context of this disorder. Affiliated tissues include small intestine and liver, and related mouse phenotypes are homeostasis/metabolism and pigmentation.

Aliases & Classifications for Hepatic Angiomyolipoma

Sources:
8Disease Ontology, 61UMLS, 40NCIt
See all sources

Aliases & Descriptions:

hepatic angiomyolipoma 8 61


External Ids:

Disease Ontology8 DOID:3317
NCIt40 C27485

Related Diseases for Hepatic Angiomyolipoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Hepatic Angiomyolipoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 100)
idRelated DiseaseScoreTop Affiliating Genes
1angiomyolipoma31.6TSC1, DES, VIM
2tuberous sclerosis30.7VIM, TSC1
3lymphangioleiomyomatosis30.3DES, TSC1
4tuberous sclerosis complex10.2
5neurofibromatosis10.1
6giant hemangioma10.1
7liver inflammatory pseudotumor10.1
8ulcerative colitis10.1
9lipoma10.0DES
10uterine sarcoma10.0DES
11desmoid tumor10.0DES
12infantile myofibromatosis10.0DES
13subependymal giant cell astrocytoma10.0TSC1
14pituitary adenoma10.0RB1
15laryngeal carcinoma10.0RB1
16adenocarcinoma in situ10.0CDKN2A
17pituitary tumors10.0RB1
18epidermolysis bullosa simplex10.0DES
19neuroblastoma10.0MYC
20familial adenomatous polyposis10.0MYC
21anaplastic oligodendroglioma10.0CDKN2A
22angiosarcoma10.0VIM
23adenomatoid tumor10.0VIM
24perineurioma10.0VIM
25myoepithelioma10.0VIM
26dedifferentiated liposarcoma10.0RB1, DES
27pneumothorax10.0TSC1
28alveolar rhabdomyosarcoma10.0RB1, DES
29medulloblastoma10.0MYC, DES
30oral cancer10.0RB1, CDKN2A
31laryngeal squamous cell carcinoma10.0RB1, CDKN2A
32li-fraumeni syndrome10.0RB1, CDKN2A
33papilloma10.0CDKN2A, RB1
34meningioma10.0TSC1, VIM
35fibromatosis10.0DES, VIM
36smooth muscle tumor10.0DES, VIM
37rhabdoid tumor10.0VIM, DES
38chordoma10.0DES, VIM
39leiomyoma10.0VIM, DES
40hemangiopericytoma10.0VIM, DES
41chondrosarcoma10.0VIM, DES
42epithelioid leiomyosarcoma10.0VIM, DES
43fibrosarcoma10.0VIM, DES
44mesenchymal chondrosarcoma10.0VIM, DES
45wilms tumor10.0DES, VIM
46pseudosarcomatous fibromatosis10.0VIM, DES
47spindle cell carcinoma10.0DES, VIM
48spindle cell sarcoma10.0VIM, DES
49alveolar soft part sarcoma10.0VIM, DES
50fibrous histiocytoma10.0DES, VIM

Graphical network of the top 20 diseases related to Hepatic Angiomyolipoma:



Diseases related to hepatic angiomyolipoma

Clinical Features for Hepatic Angiomyolipoma

Drugs & Therapeutics for Hepatic Angiomyolipoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Hepatic Angiomyolipoma

Drug clinical trials:

Search ClinicalTrials for Hepatic Angiomyolipoma

Search NIH Clinical Center for Hepatic Angiomyolipoma

Search CenterWatch for Hepatic Angiomyolipoma

Genetic Tests for Hepatic Angiomyolipoma

Anatomical Context for Hepatic Angiomyolipoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Hepatic Angiomyolipoma:

33
Small intestine, Liver

Animal Models for Hepatic Angiomyolipoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Hepatic Angiomyolipoma

Sources:
51PubMed
See all sources

Articles related to Hepatic Angiomyolipoma:

(show top 50)    (show all 123)
idTitleAuthorsYear
1
Comparison of MRI features for the differentiation of hepatic angiomyolipoma from fat-containing hepatocellular carcinoma. (24389893)
2014
2
Immunohistochemical character of hepatic angiomyolipoma: for its management. (23864864)
2013
3
Hepatic angiomyolipoma: a case report with diagnostic challenge. (24152510)
2013
4
Fat-deficient hepatic angiomyolipoma: a radiological challenge. (23701714)
2013
5
Sporadic exophytic hepatic angiomyolipoma. (23060385)
2012
6
Hepatic angiomyolipoma with a giant hemangioma. (22041879)
2011
7
Development of hepatic angiomyolipoma accompanied with focal nodular hyperplasia long after treatment of pelvic rhabdomyosarcoma. (21683235)
2011
8
Angiogenesis and lymphangiogenesis in sporadic hepatic angiomyolipoma. (21665376)
2011
9
Diagnosis and treatment of hepatic angiomyolipoma. (21283992)
2011
10
Hepatic angiomyolipoma and intramural small intestinal schwannoma: a coincidence or a relationship? (19282295)
2010
11
F-18 FDG PET/CT findings in two patients with hepatic angiomyolipoma with and without intratumoral hemorrhage. (20026966)
2010
12
Hepatic angiomyolipoma: a case report. (20518257)
2010
13
Education and Imaging. Hepatobiliary and pancreatic: imaging for hepatic angiomyolipoma. (20796161)
2010
14
Hepatic angiomyolipoma: a clinical experience in diagnosis and treatment. (20165978)
2010
15
Hepatic angiomyolipoma: dynamic computed tomography features and clinical correlation. (19610144)
2009
16
Clinical challenges and images in GI. Diagnosis: Hepatic angiomyolipoma mimicking hepatocellular carcinoma. (19254682)
2009
17
Clinical features of hepatic angiomyolipoma. (18522883)
2008
18
Massive hepatic angiomyolipoma in a young woman with tuberous sclerosis complex: significant clinical improvement during tamoxifen treatment. (18436329)
2008
19
Coincidence of hepatocelluar carcinoma and hepatic angiomyolipomas in tuberous sclerosis complex: a case report. (18205279)
2008
20
Management of hepatic angiomyolipoma. (17436129)
2007
21
Hepatic angiomyolipoma with trace amounts of fat: a case report and literature review. (17071805)
2006
22
Pathological and molecular analysis of sporadic hepatic angiomyolipoma. (16733215)
2006
23
Hepatic angiomyolipoma demonstrating similar imaging characteristics as hepatocellular carcinoma: one case report. (16463691)
2005
24
Contrast-enhanced ultrasonography in hepatic angiomyolipoma. (15914690)
2005
25
Diagnostic analysis of hepatic angiomyolipoma. (15730942)
2005
26
Growth of hepatic angiomyolipoma indicating malignant potential. (15482547)
2004
27
Hepatic angiomyolipoma: report of two cases with emphasis on smear cytomorphology and the use of cell block with immunohistochemical stains. (15452905)
2004
28
Hepatic angiomyolipoma resembling an inflammatory pseudotumor of the liver. A case report. (15648609)
2004
29
Hepatic angiomyolipoma. (12773992)
2003
30
Hepatic angiomyolipoma: various appearances on two-phase contrast scanning of spiral CT. (11750147)
2002
31
Hepatic angiomyolipoma: report of 8 cases and review of literature. (17585451)
2002
32
Correlation of MRI and CT findings with histopathology in hepatic angiomyolipoma. (11519547)
2001
33
Hepatic angiomyolipoma: a clinicopathologic study of 30 cases and delineation of unusual morphologic variants. (9888702)
1999
34
Spontaneous rupture of a hepatic angiomyolipoma: CT findings and literature review. (9087353)
1997
35
Hepatic angiomyolipoma: two case reports of caudate-based lesions and review of the literature. (9377758)
1997
36
Giant hepatic angiomyolipoma associated with disseminated intravascular coagulation. (9144010)
1997
37
Hepatic angiomyolipoma: value of breath hold 2D flash GD-dynamic imaging with fat saturation. (9690014)
1997
38
Hepatic angiomyolipoma with minimal fat content: MR demonstration. (8897374)
1996
39
Immunohistochemical study of hepatic angiomyolipoma. (10846546)
1996
40
Hepatic angiomyolipoma developing during the follow-up of ulcerative colitis: report of a case and review of the literature. (8855499)
1996
41
Hepatic angiomyolipoma: value of proton (fat/water) chemical shift fast low angle shot (FLASH) MR imaging technique in detecting fatty tissue content. (8544663)
1995
42
Hepatic angiomyolipoma in childhood: association with tuberous sclerosis. (8736611)
1995
43
Hepatic angiomyolipoma. (7820028)
1994
44
Hepatic angiomyolipoma: is fat in the liver friend or foe? (7820032)
1994
45
Hepatic angiomyolipomas with a deceptive trabecular pattern and HMB-45 reactivity. (1334941)
1992
46
Hepatic angiomyolipoma with striated granules and positivity with melanoma--specific antibody (HMB-45): a report of two cases. (1755113)
1991
47
Hepatic angiomyolipoma in a tuberous sclerosis patient. (2668223)
1989
48
Giant hepatic angiomyolipoma. (2599515)
1989
49
Renal and hepatic angiomyolipoma. (3895207)
1985
50
Hepatic angiomyolipoma. (7180967)
1982

Genetic Variations for Hepatic Angiomyolipoma

Expression for genes affiliated with Hepatic Angiomyolipoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Hepatic Angiomyolipoma

Search GEO for disease gene expression data for Hepatic Angiomyolipoma.

Pathways for genes affiliated with Hepatic Angiomyolipoma

Sources:
38NCBI BioSystems Database, 54Reactome, 30KEGG, 52QIAGEN, 12EMD Millipore
See all sources

Pathways related to Hepatic Angiomyolipoma according to GeneCards/GeneDecks:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6TSC1, MYC
29.5RB1, MYC
3
Hide members
9.4DES, VIM
49.4VIM, DES
5
Hide members
9.2CDKN2A, RB1
69.1CDKN2A, MYC
79.1RB1, MYC, TSC1
8
Hide members
9.1TSC1, MYC, RB1
98.9MYC, RB1, VIM
108.9MYC, RB1, VIM
118.7CDKN2A, MYC, RB1
128.7RB1, MYC, CDKN2A
13
Hide members
8.7CDKN2A, MYC, RB1
148.7RB1, MYC, CDKN2A
15
Hide members
8.7CDKN2A, MYC, RB1
16
Hide members
8.7RB1, MYC, CDKN2A
17
Cell cycle Cell cycle (generic schema)
Hide members
8.7RB1, MYC, CDKN2A
188.5CDKN2A, MYC, VIM
19
Hide members
8.3RB1, MYC, CDKN2A, TSC1
208.3TSC1, CDKN2A, MYC, RB1
21
Hide members
7.3VIM, RB1, DES, MYC, CDKN2A, TSC1

Compounds for genes affiliated with Hepatic Angiomyolipoma

Sources:
45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB, 60Tocris Bioscience, 2BitterDB, 29IUPHAR
See all sources

Compounds related to Hepatic Angiomyolipoma according to GeneCards/GeneDecks:

(show top 50)    (show all 72)
idCompoundScoreTop Affiliating Genes
1orcein459.8VIM, DES
2s 100459.8VIM, DES
3toluidine459.6VIM, DES
4amsacrine45 1110.6VIM, MYC
5tachyplesin i459.5CDKN2A, MYC
64-(methylnitrosamino)-1-(3-pyridyl)-1-butanone459.5CDKN2A, RB1
7reticulin459.5DES, VIM
8mucicarmine459.4VIM, DES
9hpvs459.4RB1, CDKN2A
10n-(4-hydroxyphenyl)retinamide459.3MYC, RB1, VIM
11formaldehyde45 2410.3VIM, RB1, DES
12hyaluronic acid45 2410.2MYC, DES, VIM
13glucose459.1TSC1, RRAD, CDKN2A
14hmba459.1CDKN2A, MYC, RB1
15depsipeptide459.1RB1, MYC, CDKN2A
16paclitaxel45 50 1111.1RB1, MYC, CDKN2A
17guanosine45 11 2411.0VIM, CDKN2A, TSC1
18hematoxylin459.0CDKN2A, DES, VIM
19paraffin459.0TSC1, MYC, DES, VIM
20camptothecin45 60 1111.0CDKN2A, MYC, RB1
21azathioprine45 50 2 1112.0CDKN2A, DES, VIM
22glycogen45 249.9TSC1, MYC, DES, VIM
23thymidylate458.9VIM, RB1, CDKN2A
24rapamycin458.9VIM, RB1, MYC, TSC1
25bromodeoxyuridine458.9VIM, RB1, DES, MYC
2612-o-tetradecanoylphorbol 13-acetate458.9MYC, DES, RB1, VIM
27dmso458.8MYC, RB1, VIM
28folate458.7VIM, MYC, CDKN2A
295-aza-2deoxycytidine458.6VIM, MYC, CDKN2A
30biotin45 11 2410.6CDKN2A, DES, RB1, VIM
31roscovitine458.5VIM, RB1, MYC, CDKN2A
32cytarabine45 50 1110.5VIM, RB1, MYC, CDKN2A
33vincristine45 50 1110.5VIM, RB1, MYC, CDKN2A
34agar458.5VIM, RB1, MYC, CDKN2A
35cyclic amp45 249.5VIM, RB1, DES, CDKN2A
36progesterone45 60 29 11 2412.5VIM, RB1, DES, CDKN2A
37h2o2458.4VIM, RB1, DES, CDKN2A
38genistein45 29 60 2 11 2413.4VIM, RB1, MYC, CDKN2A
39testosterone45 60 11 2411.4CDKN2A, DES, RB1, VIM
40leucine458.4CDKN2A, MYC, RB1, VIM
41adriamycin458.1VIM, RB1, DES, MYC, CDKN2A
42doxorubicin45 50 1110.1VIM, RB1, DES, MYC, CDKN2A
43actinomycin d458.1CDKN2A, MYC, DES, RB1, VIM
44dexamethasone45 50 29 1111.1CDKN2A, MYC, RB1, VIM
45estrogen458.0VIM, RB1, DES, MYC, CDKN2A
46retinoic acid45 249.0VIM, RB1, DES, MYC, CDKN2A
47threonine457.8RB1, DES, MYC, CDKN2A, RRAD, TSC1
48oligonucleotide457.8VIM, RB1, MYC, CDKN2A
49vegf457.7VIM, RB1, DES, MYC, CDKN2A, TSC1
50serine457.2VIM, RB1, DES, MYC, CDKN2A, RRAD

GO Terms for genes affiliated with Hepatic Angiomyolipoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Hepatic Angiomyolipoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein complexGO:0432348.8TSC1, CDKN2A, MYC

Biological processes related to Hepatic Angiomyolipoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:0300499.4DES, VIM
2cell cycle checkpointGO:0000758.9CDKN2A, RB1
3cell cycle arrestGO:0070508.2TSC1, CDKN2A, MYC, RB1

Molecular functions related to Hepatic Angiomyolipoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transcription factor bindingGO:0081348.7CDKN2A, MYC, RB1
2protein bindingGO:0055156.4TSC1, VIM, RB1, DES, MYC, CDKN2A

Products for genes affiliated with Hepatic Angiomyolipoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hepatic Angiomyolipoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet