MCID: HPT019
MIFTS: 51

Hepatic Encephalopathy malady

Summaries for Hepatic Encephalopathy

Sources:
43NIH Rare Diseases, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Hepatic encephalopathy is a syndrome observed in some patients with cirrhosis. it is defined as a spectrum of neuropsychiatric abnormalities in patients with liver dysfunction, when other known brain disease has been excluded. signs and symptoms may be debilitating, and they can begin mildly and gradually, or occur suddenly and severely. they may include personality or mood changes, intellectual impairment, abnormal movements, a depressed level of consciousness, and other symptoms. there are several theories regarding the exact cause, but development of the condition is probably at least partially due to the effect of substances that are toxic to nerve tissue (neurotoxic), which are typically present with liver damage and/or liver disease. treatment depends upon the severity of mental status changes and upon the certainty of the diagnosis. last updated: 1/24/2011

MalaCards: Hepatic Encephalopathy, also known as portal-systemic encephalopathy, is related to brain edema and hepatitis e. An important gene associated with Hepatic Encephalopathy is TSPO (translocator protein (18kDa)), and among its related pathways are melatonin degradation II and Alanine and aspartate metabolism. The drugs lactulose and kanamycin sulfate and the compounds milacemide and harmine have been mentioned in the context of this disorder. Related mouse phenotypes are nervous system and behavior/neurological.

Wikipedia:64 Hepatic encephalopathy (also known as portosystemic encephalopathy) is the occurrence of confusion,... more...

Aliases & Classifications for Hepatic Encephalopathy

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 40NCIt, 27ICD9CM, 35MeSH
See all sources

Aliases & Descriptions:

hepatic encephalopathy 8 43 10 45 61
portal-systemic encephalopathy 8
encephalopathy, hepatic 43
hepatoencephalopathy 43


External Ids:

Disease Ontology8 DOID:13413
NCIt40 C79596
ICD9CM27 572.2
MeSH35 D006501

Related Diseases for Hepatic Encephalopathy

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Hepatic Encephalopathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 168)
idRelated DiseaseScoreTop Affiliating Genes
1brain edema30.7ALB, SLC25A13, GLUL, AQP4
2hepatitis e30.6GPT
3acute liver failure30.6SLC17A5, GC, GPT, F2, TSPO, ALB
4hepatitis a30.5F2
5hepatitis c30.5SLC17A5, GPT, F2
6hepatic coma30.4F2, TSPO
7alcoholic hepatitis30.4SLC17A5, F2, ALB, GPT
8blindness30.3TSPO, MAOB
9toxic encephalopathy30.3GLUL, MAOA, MAOB
10wilson disease30.2GPT, SLC17A5
11urea cycle disorder30.1ASS1
12portal hypertension30.1ALB, GPT, MAOA, SLC17A5, F2
13citrin deficiency29.9SLC25A13
14viral hepatitis29.9SLC17A5, GPT, F2
15alzheimer's disease29.9CSN1S1, CHERP, MAOA, NOS1, ASS1, TSPO
16hepatitis d10.3
17h. pylori infection10.3
18status epilepticus10.2
19cortical blindness10.2
20hepatic vein thrombosis10.2
21combined oxidative phosphorylation deficiency 110.2
22spastic paraparesis10.1
23portal vein thrombosis10.1
24autonomic neuropathy10.1
25hepatitis c virus10.1
26infections, recurrent, with encephalopathy, hepatic dysfunction, and cardiovasuclar malformations10.1
27prion disease10.0TSPO
28severe pre-eclampsia10.0MAOA
29alcohol dependence10.0MAOA
30anorexia nervosa10.0MAOA
31huntington's disease10.0ATXN3
32fibromyalgia10.0TSPO
33intrahepatic cholestasis10.0SLC25A13
34hyperthyroidism10.0SLC17A5
35reye syndrome10.0GLUL
36malaria10.0ALB
37thromboembolism10.0F2
38lung cancer10.0ALB
39meningitis10.0ALB
40migraine10.0MAOB, MAOA
41myocardial infarction10.0NOS1
42acquired immunodeficiency syndrome10.0ALB
43stroke, ischemic10.0AQP4, TSPO
44spinocerebellar ataxia10.0ATXN3
45parkinson's disease10.0MAOB, MAOA
46anxiety disorder10.0MAOA
47pneumonia10.0NOS1
48acute myocardial infarction10.0NOS1
49cryoglobulinemia10.0SLC17A5
50herpes simplex10.0GC, GLUL

Graphical network of the top 20 diseases related to Hepatic Encephalopathy:



Diseases related to hepatic encephalopathy

Clinical Features for Hepatic Encephalopathy

Drugs & Therapeutics for Hepatic Encephalopathy

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Hepatic Encephalopathy

Drug clinical trials:

Search ClinicalTrials for Hepatic Encephalopathy

Search NIH Clinical Center for Hepatic Encephalopathy

Search CenterWatch for Hepatic Encephalopathy

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Hepatic Encephalopathy

Anatomical Context for Hepatic Encephalopathy

Animal Models for Hepatic Encephalopathy or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Hepatic Encephalopathy:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036319.5SLC17A5, AQP4, ASS1, ATXN3, MAOA, MAOB
2MP:00053869.2AQP4, ATXN3, ASS1, NOS1, SLC17A5, GLUL
3MP:00053769.1GC, AQP4, ALB, ASS1, NOS1, SLC17A5

Publications for Hepatic Encephalopathy

Sources:
51PubMed
See all sources

Articles related to Hepatic Encephalopathy:

(show top 50)    (show all 613)
idTitleAuthorsYear
1
The nutritional management of hepatic encephalopathy in patients with cirrhosis: International Society for Hepatic Encephalopathy and Nitrogen Metabolism Consensus. (23471642)
2013
2
Cerebral oedema is rare in acute-on-chronic liver failure patients presenting with high-grade hepatic encephalopathy. (23844567)
2013
3
GABAergic transmission in hepatic encephalopathy. (23624382)
2013
4
Preventive effect of N-acetyl-L-cysteine on oxidative stress and cognitive impairment in hepatic encephalopathy following bile duct ligation. (23044263)
2013
5
Resting state cortical electroencephalographic rhythms in covert hepatic encephalopathy and Alzheimer's disease. (23271320)
2013
6
Excessive daytime sleepiness and hepatic encephalopathy: it is worth asking. (23180317)
2013
7
Muscle depletion increases the risk of overt and minimal hepatic encephalopathy: results of a prospective study. (23224378)
2013
8
Mapping metabolic brain activity in three models of hepatic encephalopathy. (23573412)
2013
9
Rifaximin is an efficacious treatment for the Parkinsonian phenotype of hepatic encephalopathy. (23471844)
2013
10
The continuous reaction times method for diagnosing, grading, and monitoring minimal/covert hepatic encephalopathy. (23299303)
2013
11
Gut microbiota and hepatic encephalopathy. (23463489)
2013
12
In patients with liver cirrhosis, proinflammatory interleukins correlate with health-related quality of life irrespective of minimal hepatic encephalopathy. (24025977)
2013
13
Psychometric hepatic encephalopathy score for the detection of minimal hepatic encephalopathy in Korean patients with liver cirrhosis. (22743001)
2012
14
Conscious recovery response in post-hepatic transplant as a function of time-related acute hepatic encephalopathy. (22410033)
2012
15
Hepatic encephalopathy. (22504749)
2012
16
Structural and functional cerebral impairments in cirrhotic patients with a history of overt hepatic encephalopathy. (22056487)
2012
17
Dogs with congenital porto-systemic shunting (cPSS) and hepatic encephalopathy have higher serum concentrations of C-reactive protein than asymptomatic dogs with cPSS. (22354751)
2012
18
Spectral and dynamic electroencephalogram abnormalities are correlated to psychometric test performance in hepatic encephalopathy. (21612322)
2011
19
Rifaximin treatment for reduction of risk of overt hepatic encephalopathy recurrence. (21694804)
2011
20
Hepatic encephalopathy after treatment with temozolomide. (20730617)
2011
21
Pro-inflammatory cytokines are raised in extrahepatic portal venous obstruction, with minimal hepatic encephalopathy. (21362045)
2011
22
Selective cyclooxygenase inhibition improves hepatic encephalopathy in fulminant hepatic failure of rat. (21575628)
2011
23
New assessment of hepatic encephalopathy. (21145874)
2011
24
Screening for minimal hepatic encephalopathy in asymptomatic drivers with liver cirrhosis. (21684474)
2011
25
Evidence of persistent cognitive impairment after resolution of overt hepatic encephalopathy. (20951832)
2011
26
Effect of oral zinc in hepatic encephalopathy remains unclear. (21050244)
2010
27
Changing face of hepatic encephalopathy: role of inflammation and oxidative stress. (20632436)
2010
28
Hepatic encephalopathy as a complication of liver cirrhosis: an Asian perspective. (20546438)
2010
29
Acute hepatic encephalopathy: diffusion-weighted and fluid-attenuated inversion recovery findings, and correlation with plasma ammonia level and clinical outcome. (20448015)
2010
30
Rifaximin treatment in hepatic encephalopathy. (20578274)
2010
31
Colostomy successfully rescued refractory hepatic encephalopathy. (21352683)
2010
32
Hepatic encephalopathy: current management strategies and treatment, including management and monitoring of cerebral edema and intracranial hypertension in fulminant hepatic failure. (20124996)
2010
33
Reversal learning impairment and alterations in the prefrontal cortex and the hippocampus in a model of portosystemic hepatic encephalopathy. (21114133)
2010
34
Motor-evoked potentials in awake rats are a valid method of assessing hepatic encephalopathy and of studying its pathogenesis. (20890898)
2010
35
Critical flicker frequency for diagnosis and assessment of recovery from minimal hepatic encephalopathy in patients with cirrhosis. (20133225)
2010
36
Role of artificial liver support in hepatic encephalopathy. (19101787)
2009
37
Albumin dialysis has a favorable effect on amino acid profile in hepatic encephalopathy. (18773287)
2008
38
Serum S100b (astrocyte-specific protein) is a useful marker of hepatic encephalopathy in patients with fulminant hepatitis. (18173564)
2008
39
Prediction of hepatic encephalopathy development in patients with severe acute hepatitis. (16534681)
2006
40
Reversal of diuretic-induced hepatic encephalopathy with infusion of albumin but not colloid. (14678008)
2004
41
Pathogenesis of hepatic encephalopathy. (12472946)
2002
42
Altered striatal dopamine D2 receptor density and dopamine transport in a patient with hepatic encephalopathy. (11206586)
2000
43
Behavioral and physiological sex differences observed in an animal model of fulminant hepatic encephalopathy in the rat. (9333208)
1997
44
Endotoxin and tumor necrosis factor-alpha in the pathogenesis of hepatic encephalopathy. (7963364)
1994
45
A study of 3H-PK 11,195 binding to "peripheral-type" benzodiazepine receptors on human lymphocytes. Evidence of decreased binding in hepatic encephalopathy. (1649262)
1991
46
The contribution of endogenous benzodiazepine receptor ligands to the pathogenesis of hepatic encephalopathy. (1849322)
1991
47
Brain GABA and benzodiazepine receptors in hepatic encephalopathy. (19256153)
1990
48
Benzodiazepine receptor ligands and the syndrome of hepatic encephalopathy. (2156301)
1990
49
Hepatic encephalopathy associated with patent ductus venosus in a calf. (6874505)
1983
50
Transient cortical blindness in hepatic encephalopathy. (521266)
1979

Genetic Variations for Hepatic Encephalopathy

Expression for genes affiliated with Hepatic Encephalopathy

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Hepatic Encephalopathy

Search GEO for disease gene expression data for Hepatic Encephalopathy.

Pathways for genes affiliated with Hepatic Encephalopathy

Sources:
38NCBI BioSystems Database, 54Reactome, 30KEGG
See all sources

Pathways related to Hepatic Encephalopathy according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.3MAOB, MAOA
210.2GPT, ASS1
3
Hide members
10.1MAOA, GLS, GLS2
4
Hide members
10.1GLS2, GLS, MAOA
5
Hide members
10.1NOS1, GLS2, GLS
6
Hide members
10.0GLS2, GLUL, GLS, MAOA
710.0GLS, GLUL, GLS2, GPT
89.9GLS, GLUL, GLS2, GPT, ASS1
99.9GLS, GLUL, GLS2, GPT, ASS1
10
Hide members
9.8MAOA, MAOB, GLS, GLUL, GLS2, NOS1
11
Hide members
9.7GC, MAOA, MAOB, DPAGT1, GLS, GLUL
12
Hide members
9.7ASS1, NOS1, GLS2, GLUL, GLS, MAOB

Compounds for genes affiliated with Hepatic Encephalopathy

Sources:
45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB, 29IUPHAR, 2BitterDB, 60Tocris Bioscience
See all sources

Compounds related to Hepatic Encephalopathy according to GeneCards/GeneDecks:

(show top 50)    (show all 205)
idCompoundScoreTop Affiliating Genes
1milacemide4510.6MAOB, SLC17A5, MAOA
2harmine4510.6MAOB, MAOA, TSPO
3beta-carboline4510.5MAOB, MAOA, TSPO
4d amphetamine4510.5MAOA, MAOB, TSPO
5hepaplastin4510.4F2, SLC17A5, ALB, GPT
6ammonium4510.4GLS, ASS1, SLC17A5, GLUL
7flavin4510.3MAOA, SGCB, NOS1, MAOB
8isoflurane45 1111.3GPT, SLC17A5, TSPO, ALB
9citrulline45 2411.3NOS1, ASS1, SGCB, SLC25A13, GLS
10bicarbonate4510.3AQP4, GLS, GC, ALB, GLS2
11alpha-ketoglutarate4510.3MAOB, GLS, GLUL, GLS2, GPT
12phosphorus4510.3SLC17A5, GC, GPT, ALB
13fluoxetine50 45 29 1113.2MAOA, NOS1, MAOB, ALB
14pyridoxal 5-phosphate4510.2GPT, ALB, SLC17A5, GLS
15vitamin b124510.2GPT, CSN1S1, ALB, MAOB, SLC17A5
165-hydroxytryptamine4510.2NOS1, SGCB, F2, MAOA, MAOB, TSPO
17asparagine4510.2ASS1, DPAGT1, GLS, GLUL, GPT
18mptp4510.2MAOA, TSPO, MAOB, NOS1
19cocaine45 1111.2GPT, SLC17A5, MAOB, NOS1, TSPO
20acetaminophen45 2 50 11 2414.2SLC17A5, GC, F2, GPT, CSN1S1
21nicotine45 50 29 1113.2MAOB, GPT, SLC17A5, NOS1, MAOA, TSPO
22estrogen4510.2GLUL, MAOB
23glycerol45 11 2412.2AQP4, TSPO, GLUL, SLC25A13, NOS1, CSN1S1
24phenelzine45 1111.1GPT, MAOB, MAOA
25nmda45 2911.1TSPO, SGCB, NOS1, GLS, MAOB, MAOA
26citrate4510.1CSN1S1, F2, ALB, GLUL, GLS, GLS2
27gaba4510.1GLS, MAOA, GLUL, TSPO, NOS1, MAOB
28choline45 11 2412.1MAOB, NOS1, MAOA, GLS, GPT
29methotrexate45 50 1112.1F2, SLC17A5, GLS, NOS1, ALB, GPT
30norepinephrine45 11 2412.1NOS1, SLC17A5, MAOB, MAOA, TSPO, GLUL
31h2o24510.1MAOB, CSN1S1, SGCB, TSPO, MAOA, GLUL
32thyroxine45 2411.0GPT, GC, CSN1S1, SLC17A5, ALB
33histamine45 29 2412.0NOS1, MAOB, MAOA, CSN1S1, TSPO, ALB
34fibrinogen4510.0SLC17A5, GC, CSN1S1, GPT, ALB, F2
35carbon4510.0CSN1S1, MAOA, MAOB, GLUL, NOS1
36folate459.9ALB, SLC17A5, MAOB, CSN1S1, NOS1
37ascorbic acid45 2410.8GLUL, DPAGT1, MAOB, SLC17A5, SGCB, ALB
38lactate459.8SLC17A5, ALB, MAOB, GLS, GLUL, GLS2
39cholesterol45 29 11 2412.8CSN1S1, GC, DPAGT1, GLS2, GPT, SLC17A5
40cysteine459.8CSN1S1, ATXN3, MAOA, MAOB, GLS, GLUL
41arginine459.8NOS1, GPT, GLS2, GLUL, CSN1S1, GLS
42alanine459.8ASS1, CSN1S1, GLUL, GPT, F2, SLC17A5
43oxygen45 2410.7GLS, MAOA, GLUL, GLS2, SGCB, MAOB
44testosterone45 60 11 2412.7SGCB, ALB, TSPO, GC, NOS1, SLC17A5
45glutamine459.7GLS, GPT, ATXN3, SLC17A5, TSPO, GLS2
46urea45 11 2411.6ALB, GLUL, AQP4, GLS, ASS1, SLC17A5
47potassium45 11 2411.5SLC17A5, GPT, SGCB, ALB, GLS, AQP4
48creatinine459.5GC, CSN1S1, MAOB, DPAGT1, GLUL, GPT
49aspartate459.4GLS2, ALB, GLUL, GLS, CSN1S1, GC
50glutamate459.2AQP4, TSPO, ASS1, SGCB, GC, CSN1S1

GO Terms for genes affiliated with Hepatic Encephalopathy

Sources:
16Gene Ontology
See all sources

Cellular components related to Hepatic Encephalopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein complexGO:04323410.0AQP4, ALB, NOS1, GLUL

Biological processes related to Hepatic Encephalopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1anion transportGO:00682010.3TSPO, SLC17A5
2cellular amino acid biosynthetic processGO:00865210.1GPT, GLS2, GLUL, GLS
3cellular nitrogen compound metabolic processGO:0346419.9GLS, GLUL, GLS2, GPT, ASS1
4neurotransmitter secretionGO:0072699.8GLS2, GLS, MAOA
5synaptic transmissionGO:0072689.8ATXN3, MAOA, GLS, GLUL, GLS2
6small molecule metabolic processGO:0442819.4GC, MAOA, MAOB, GLS, GLUL, GLS2

Molecular functions related to Hepatic Encephalopathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1primary amine oxidase activityGO:00813110.3MAOB, MAOA
2glutaminase activityGO:0043599.9GLS2, GLS

Products for genes affiliated with Hepatic Encephalopathy

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hepatic Encephalopathy

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet