Hepatic Lipase Deficiency disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

NIH Rare Diseases:⁴⁸ Hepatic lipase deficiency is a rare condition that is characterized by increased levels of certain fats (known as triglycerides and cholesterol) in the blood. affected people may also have increased levels of high-density lipoproteins (hdls) and decreased levels of low-density lipoproteins (ldls), which are two molecules that help transport fats throughout the body. hepatic lipase deficiency may be associated with an increased risk of developing atherosclerosis and/or heart disease; however, additional research is needed on the long-term outlook of people with this condition. hepatic lipase deficiency is caused by changes (mutations) in the lipc gene and is inherited in an autosomal recessive manner. treatment is based on the signs and symptoms present in each person. last updated: 4/2/2016

MalaCards based summary: Hepatic Lipase Deficiency, also known as hyperlipidemia due to hepatic triglyceride lipase deficiency, is related to hmg-coa lyase deficiency and hepatitis, and has symptoms including angina pectoris, angina pectoris and Array. An important gene associated with Hepatic Lipase Deficiency is LIPC (Lipase C, Hepatic Type), and among its related pathways are Mitochondrial LC-Fatty Acid Beta-Oxidation and triacylglycerol degradation. Affiliated tissues include heart, liver and adrenal gland, and related mouse phenotypes are Increased LDL uptake and Decreased free cholesterol.

Genetics Home Reference:²⁵ Hepatic lipase deficiency is a disorder that affects the body's ability to break down fats (lipids). People with this disorder have increased amounts of certain fats, known as triglycerides and cholesterol, in the blood. These individuals also have increased amounts of molecules known as high-density lipoproteins (HDLs) and decreased amounts of molecules called low-density lipoproteins (LDL). These molecules transport triglycerides and cholesterol throughout the body. In people with hepatic lipase deficiency, the LDL molecules are often abnormally large.

UniProtKB/Swiss-Prot:⁷⁰ Hepatic lipase deficiency: A disorder characterized by elevated levels of beta-migrating very low density lipoproteins, and abnormally triglyceride-rich low and high density lipoproteins.

Wikipedia:⁷¹ Hepatic lipase, also called hepatic triglyceride lipase (HTGL) or LIPC (for \"lipase, hepatic\"), is a... more...

Description from OMIM:⁵² 614025

Related Diseases for Hepatic Lipase Deficiency

Sources:
²⁰GeneAnalytics, ²¹GeneCards
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Diseases related to Hepatic Lipase Deficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)

id	Related Disease	Score	Top Affiliating Genes
1	hmg-coa lyase deficiency	11.0
2	hepatitis	10.4
3	polycystic kidney disease, infantile severe, with tuberous sclerosis	10.1	LIPC, LPL
4	pleural disease	10.0	LIPC, PNLIP
5	alport syndrome and thin basement membrane nephropathy	10.0	APOE, LPL
6	c1s deficiency	9.9	APOE, LPL
7	myxofibrosarcoma	9.9	APOE, LPL
8	asphyxia neonatorum	9.9	APOE, LPL
9	abducens nerve neoplasm	9.9	LIPC, LPL, PNLIP
10	familial progressive cardiac conduction defect	9.9	APOA1, APOE
11	albinism, oculocutaneous, type v	9.9	APOA1, APOE
12	lacrimal system cancer	9.9	LPL, PNLIP
13	pars planitis	9.9	APOA1, APOE
14	stone in bladder diverticulum	9.9	APOA1, APOE
15	primary pigmented nodular adrenocortical disease	9.9	APOA1, APOE
16	gait apraxia	9.9	APOA1, APOE
17	optic nerve neoplasm	9.8	APOA1, APOE
18	neuropathy, hereditary sensory and autonomic, type ia	9.8	APOA1, APOE
19	atherosclerosis	9.8
20	severe intellectual disability-progressive postnatal microcephaly- midline stereotypic hand movements syndrome	9.8	APOE, LIPC, LPL
21	dyserythropoietic anemia, congenital, type ii	9.8	APOA1, APOE
22	hard palate cancer	9.8	APOA1, APOE
23	joint disorders	9.7	APOA1, APOE, LPL
24	bird fancier's lung	9.7	APOA1, APOE, LPL
25	von willebrand disease, platelet-type	9.7	APOA1, APOE, LPL
26	mannosidosis, beta	9.7	APOA1, APOE, LPL
27	pyrimidine metabolic disorder	9.7	APOA1, APOE, LPL
28	pericarditis	9.7	APOA1, APOE, LPL
29	cervix small cell carcinoma	9.7	APOA1, APOE
30	myocardial infarction	9.7
31	hypoalphalipoproteinemia	9.7
32	glucose intolerance	9.7
33	skin squamous cell carcinoma	9.6	APOA1, APOE, LIPC, LPL
34	bleeding disorder, east texas type	9.6	APOA1, APOE, LIPC, LPL
35	hypertriglyceridemia	9.6	APOA1, APOE, LIPC, LPL
36	cataract 5, multiple types	9.6	APOA1, APOE, LIPC, LPL
37	acute apical periodontitis	9.6	APOA1, APOE, LIPC, LPL
38	lipomatosis	9.6	APOA1, APOE, LIPC, LPL
39	immunodeficiency 18	9.6	APOA1, APOE, LIPC, LPL
40	narcolepsy 6	9.6	APOA1, APOE, LIPC, LPL
41	autoimmune-related retinopathy and optic neuropathy	9.6	APOA1, APOE, LIPC, LPL
42	macular degeneration, age-related, 12	9.6	APOA1, APOE, LIPC, LPL
43	chondrocalcinosis with early-onset osteoarthritis	9.6	APOA1, APOE, LPL, PNLIP
44	maturity-onset diabetes of the young 6	9.5	APOA1, APOE, LIPC, LPL
45	hyperchlorhidrosis, isolated	9.4	APOA1, APOE, LIPC, LPL, PNLIP
46	von hippel-lindau syndrome	9.4	APOA1, APOE, LIPC, LPL, PNLIP

Graphical network of the top 20 diseases related to Hepatic Lipase Deficiency:

Symptoms & Phenotypes for Hepatic Lipase Deficiency

Sources:
²⁶GenomeRNAi, ⁴¹MGI, ⁵²OMIM, ⁵⁴Orphanet, ⁶⁴The Human Phenotype Ontology, ⁶⁸UMLS
See all MalaCards sources

Symptoms by clinical synopsis from OMIM:

614025

Clinical features from OMIM:

614025

Human phenotypes related to Hepatic Lipase Deficiency:

⁵⁴ ⁶⁴

id	Description	Orphanet Frequency	HPO Source Accession
1	hypertriglyceridemia⁶⁴ ⁵⁴	Obligate (100%)	HP:0002155
2	hyperalphalipoproteinemia⁶⁴ ⁵⁴	Obligate (100%)	HP:0012184
3	eruptive xanthomas⁶⁴ ⁵⁴	Very frequent (99-80%)	HP:0001013
4	angina pectoris⁶⁴ ⁵⁴	Frequent (79-30%)	HP:0001681
5	premature coronary artery disease⁶⁴ ⁵⁴	Frequent (79-30%)	HP:0005181

UMLS symptoms related to Hepatic Lipase Deficiency:

angina pectoris

GenomeRNAi Phenotypes related to Hepatic Lipase Deficiency according to GeneCards Suite gene sharing:

²⁶

id	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased LDL uptake	GR00340-A-1	9.2	APOA1, APOE, LPL
2	Decreased free cholesterol	GR00340-A-2	8.9	APOA1, APOE, LIPC, LPL

MGI Mouse Phenotypes related to Hepatic Lipase Deficiency according to GeneCards Suite gene sharing:

⁴¹

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	8.2	APOA1, APOE, LIPC, LPL, PNLIP
2	liver/biliary system	MP:0005370	8.0	APOA1, APOE, LPL, PNLIP

Drugs & Therapeutics for Hepatic Lipase Deficiency

Sources:
¹BitterDB, ⁴ClinicalTrials, ¹⁰DGIdb, ¹⁴DrugBank, ²⁹HMDB, ³³IUPHAR, ⁵⁰Novoseek, ⁵⁶PharmGKB
See all MalaCards sources

Drugs for Hepatic Lipase Deficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

id		Name	Status	Phase	Clinical Trials	Cas Number	PubChem Id
1		Liver Extracts			4067

Interventional clinical trials:

id	Name	Status	NCT ID	Phase
1	A Multicenter Study of SBC-102 (Sebelipase Alfa) in Patients With Lysosomal Acid Lipase Deficiency/ ARISE (Acid Lipase Replacement Investigating Safety and Efficacy)	Active, not recruiting	NCT01757184	Phase 3
2	Novel Association of Cholesterol Ester Storage Disease Due to Lysosomal Acid Lipase Deficiency and Non-Alcoholic Fatty Liver Disease: A Prospective Clinical Study	Unknown status	NCT01791452
3	Assessement of the Prevalence of Lysosomal Acid Lipase Deficiency in Liver Post-transplant Patients	Recruiting	NCT02851550
4	Assessment of the Prevalence of Lysosomal Acid Lipase Deficiency in Patients Waiting for a Liver Transplant.	Recruiting	NCT02852304
5	National Lysosomal Acid Lipase Deficiency Study	Recruiting	NCT02372513
6	Screening for Lysosomal Acid Lipase Deficiency	Active, not recruiting	NCT02926872

Search NIH Clinical Center for Hepatic Lipase Deficiency

Genetic Tests for Hepatic Lipase Deficiency

Sources:
²⁴GeneTests, ²⁷GTR
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Genetic tests related to Hepatic Lipase Deficiency:

id	Genetic test	Affiliating Genes
1	Hepatic Lipase Deficiency²⁷ ²⁴	LIPC

Anatomical Context for Hepatic Lipase Deficiency

Sources:
³⁶MalaCards
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MalaCards organs/tissues related to Hepatic Lipase Deficiency:

³⁶

Heart, Liver, Adrenal gland

Publications for Hepatic Lipase Deficiency

Sources:
⁵⁷PubMed
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Articles related to Hepatic Lipase Deficiency:

(show all 31)

id	Title	Authors	Year
1	High-density lipoprotein subpopulation profiles in lipoprotein lipase and hepatic lipase deficiency. (27573733)	Tani M.... Asztalos B.F.	2016
2	Hepatic lipase deficiency produces glucose intolerance, inflammation and hepatic steatosis. (26423094)	AndrAcs-Blasco I.... GonzA!lez-Navarro H.	2015
3	Hepatic lipase deficiency in a Middle-Eastern-Arabic male. (22798447)	Al Riyami N.... Frohlich J.	2010
4	Hepatic lipase deficiency delays atherosclerosis, myocardial infarction, and cardiac dysfunction and extends lifespan in SR-BI/apolipoprotein E double knockout mice. (16397139)	Karackattu S.L.... Krieger M.	2006
5	Plasma metabolism of apoB-containing lipoproteins in patients with hepatic lipase deficiency. (15910863)	Ruel I.L.... Lamarche B.	2005
6	Effect of fenofibrate on plasma lipoprotein composition and kinetics in patients with complete hepatic lipase deficiency. (16224048)	Ruel I.L.... Couture P.	2005
7	Severe hypoalphalipoproteinemia in mice expressing human hepatic lipase deficient in binding to heparan sulfate proteoglycan. (15292235)	Brown R.J.... Yao Z.	2004
8	Evidence that hepatic lipase deficiency in humans is not associated with proatherogenic changes in HDL composition and metabolism. (15175359)	Ruel I.L.... Lamarche B.	2004
9	Lipoprotein metabolism in subjects with hepatic lipase deficiency. (15045702)	Tilly-Kiesi M.... Lichtenstein A.H.	2004
10	Characterization of a novel mutation causing hepatic lipase deficiency among French Canadians. (12777476)	Ruel I.L.... Lamarche B.	2003
11	Hepatic lipase deficiency attenuates mouse ovarian progesterone production leading to decreased ovulation and reduced litter size. (11906928)	Wade R.L.... Dyer C.A.	2002
12	Hepatic lipase deficiency decreases the selective uptake of HDL-cholesteryl esters in vivo. (10787427)	Lambert G.... Santamarina-Fojo S.	2000
13	Atorvastatin in the management of an index patient with complete hepatic lipase deficiency. (10208500)	Hegele R.A.... Connelly P.W.	1999
14	Hepatic lipase deficiency. (9885775)	Connelly P.W.... Hegele R.A.	1998
15	Heterozygous hepatic lipase deficiency, due to two missense mutations R186H and L334F, in the HL gene. (9050773)	Knudsen P.... Ehnholm C.	1997
16	Hepatic lipase deficiency increases plasma cholesterol but reduces susceptibility to atherosclerosis in apolipoprotein E-deficient mice. (9153204)	Mezdour H.... Maeda N.	1997
17	Acute dyslipoproteinemia induced by interleukin-2: lecithin:cholesteryl acyltransferase, lipoprotein lipase, and hepatic lipase deficiencies. (9141552)	Kwong L.K.... Wilson D.E.	1997
18	Effects of short-term stanozolol administration on serum lipoproteins in hepatic lipase deficiency. (9284885)	Bausserman L.L.... Herbert P.N.	1997
19	Analysis of protein structure-function in vivo. Adenovirus-mediated transfer of lipase lid mutants in hepatic lipase-deficient mice. (8824281)	Kobayashi J.... Santamarina-Fojo S.	1996
20	Hepatic lipase gene therapy in hepatic lipase-deficient mice. Adenovirus-mediated replacement of a lipolytic enzyme to the vascular endothelium. (8609237)	Applebaum-Bowden D.... Santamarina-Fojo S.	1996
21	Molecular characterization of human hepatic lipase deficiency. In vitro expression of two naturally occurring mutations. (8123642)	Durstenfeld A.... Doolittle M.H.	1994
22	Beta-VLDL in hepatic lipase deficiency induces apoE-mediated cholesterol ester accumulation in macrophages. (8364012)	Huff M.W.... Hegele R.A.	1993
23	Hepatic lipase deficiency. Clinical, biochemical, and molecular genetic characteristics. (8485124)	Hegele R.A.... Connelly P.W.	1993
24	Compound heterozygosity for mutant hepatic lipase in familial hepatic lipase deficiency. (1883393)	Hegele R.A.... Connelly P.W.	1991
25	The molecular basis of hepatic lipase deficiency. (1933710)	Hegele R.A.	1991
26	Plasma lipoproteins in familial hepatic lipase deficiency. (2297346)	Connelly P.W.... Little J.A.	1990
27	The rabbit as an animal model of hepatic lipase deficiency. (2930766)	Clay M.A.... Barter P.J.	1989
28	Large buoyant LDL-like particles in hepatic lipase deficiency. (2719594)	Auwerx J.H.... Brunzell J.D.	1989
29	The beta very low density lipoprotein present in hepatic lipase deficiency competitively inhibits low density lipoprotein binding to fibroblasts and stimulates fibroblast acyl-CoA:cholesterol acyltransferase. (3170542)	Connelly P.W.... Little J.A.	1988
30	Lipoprotein metabolism in hepatic lipase deficiency: studies on the turnover of apolipoprotein B and on the effect of hepatic lipase on high density lipoprotein. (3244012)	Demant T.... Shepherd J.	1988
31	Familial hepatic lipase deficiency. (3799360)	Little J.A.... Connelly P.W.	1986

Genes related to Hepatic Lipase Deficiency

Sources:
⁵Clinvar, ²¹GeneCards, ²⁴GeneTests, ⁵²OMIM, ⁵⁴Orphanet, ⁷⁰UniProtKB/Swiss-Prot
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Genes related to Hepatic Lipase Deficiency (1 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

id	Symbol	Description	Score	Implication	PubmedIds
1	LIPC	Lipase C, Hepatic Type	1690.36	Molecular basis known ⁵² Pathogenic ⁵ Causative germline mutation ⁵⁴ Causative variation ⁷⁰ Genetic Tests ²⁴ GeneCards inferred via : Disorders, Publications, Variants (show sections)	1671786, 1883393, 12777476
2	LPL	Lipoprotein Lipase	28.44	GeneCards inferred via : Disorders, Publications (show sections)
3	APOA1	Apolipoprotein A1	28.17	GeneCards inferred via : Disorders, Publications (show sections)
4	APOE	Apolipoprotein E	27.95	GeneCards inferred via : Disorders, Publications (show sections)
5	PNLIP	Pancreatic Lipase	27.95	GeneCards inferred via : Disorders, Publications (show sections)

Variations for Hepatic Lipase Deficiency

Sources:
⁵Clinvar, ⁹dbSNP, ⁷⁰UniProtKB/Swiss-Prot
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UniProtKB/Swiss-Prot genetic disease variations for Hepatic Lipase Deficiency:

⁷⁰

id	Symbol	AA change	Variation ID	SNP ID
1	LIPC	p.Ser289Phe	VAR_004209	rs121912502
2	LIPC	p.Thr405Met	VAR_004210	rs113298164

Clinvar genetic disease variations for Hepatic Lipase Deficiency:

⁵

id	Gene	Variation	Type	Significance	SNP ID	Assembly	Location
1	LIPC	NM_ 000236.2(LIPC): c.1214C> T (p.Thr405Met)	SNV	Pathogenic	rs113298164	GRCh37	Chr 15, 58855748: 58855748
2	LIPC	LIPC, ALA174THR	SNV	Pathogenic

Expression for genes affiliated with Hepatic Lipase Deficiency

Sources:
¹⁸Gene Expression Omnibus DataSets
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Search GEO for disease gene expression data for Hepatic Lipase Deficiency.

Pathways for genes affiliated with Hepatic Lipase Deficiency

Sources:
³Cell Signaling Technology, ³⁴KEGG, ⁴²NCBI BioSystems Database, ⁵⁵PathCards, ⁵⁶PharmGKB, ⁶⁰Reactome
See all MalaCards sources

Pathways related to Hepatic Lipase Deficiency according to GeneCards Suite gene sharing:

(show all 14)

id	Super pathways	Score	Top Affiliating Genes
1	Mitochondrial LC-Fatty Acid Beta-Oxidation⁴² Show member pathways Fatty Acid Beta Oxidation⁴² fatty acid beta-oxidation (unsaturated, odd number)⁴²	9.5	LIPC, LPL
2	triacylglycerol degradation⁴²	9.5	LIPC, PNLIP
3	the visual cycle I (vertebrates)⁴² Show member pathways The canonical retinoid cycle in rods (twilight vision)⁶⁰ retinol biosynthesis⁴²	9.5	LIPC, PNLIP
4	PPAR signaling pathway³⁴	9.3	APOA1, LPL
5	Fat digestion and absorption³⁴ Show member pathways Trafficking of dietary sterols⁶⁰	9.3	APOA1, PNLIP
6	Vitamin digestion and absorption³⁴	9.3	APOA1, PNLIP
7	Binding and Uptake of Ligands by Scavenger Receptors⁶⁰ Show member pathways Scavenging by Class A Receptors⁶⁰ Scavenging of heme from plasma⁶⁰ Scavenging by Class B Receptors⁶⁰ Scavenging by Class H Receptors⁶⁰ Scavenging by Class F Receptors⁶⁰	9.0	APOA1, APOE
8	Ca, cAMP and Lipid Signaling³	9.0	APOA1, APOE
9	triacylglycerol biosynthesis⁴² Show member pathways CDP-diacylglycerol biosynthesis⁴² Glycerolipid metabolism³⁴ Triacylglyceride Synthesis⁴²	9.0	LIPC, LPL, PNLIP
10	Statin Pathway⁴² Show member pathways Statin Pathway, Pharmacodynamics⁵⁶ Composition of Lipid Particles⁴²	8.1	APOA1, APOE, LIPC, LPL
11	Metabolism of fat-soluble vitamins⁶⁰ Show member pathways Visual phototransduction⁶⁰ Retinoid metabolism and transport⁶⁰ Vitamin D (calciferol) metabolism⁶⁰ The retinoid cycle in cones (daylight vision)⁶⁰ Metabolism of vitamin K⁶⁰	8.0	APOA1, APOE, LPL, PNLIP
12	Metabolism of water-soluble vitamins and cofactors⁶⁰ Show member pathways Metabolism of vitamins and cofactors⁶⁰ Vitamin B5 (pantothenate) metabolism⁶⁰ Biotin transport and metabolism⁶⁰ biotin-carboxyl carrier protein assembly⁴² Vitamin B2 (riboflavin) metabolism⁶⁰ Molybdenum cofactor biosynthesis⁶⁰ thio-molybdenum cofactor biosynthesis⁴² molybdenum cofactor biosynthesis⁴² Vitamins B6 activation to pyridoxal phosphate⁶⁰ folate polyglutamylation⁴² Metabolism of folate and pterines⁶⁰ Vitamin C (ascorbate) metabolism⁶⁰ [2Fe-2S] iron-sulfur cluster biosynthesis⁴² flavin biosynthesis⁴² Coenzyme A biosynthesis⁶⁰ coenzyme A biosynthesis⁴² Vitamin B1 (thiamin) metabolism⁶⁰ thiamin salvage III⁴²	8.0	APOA1, APOE, LPL, PNLIP
13	Metabolism⁶⁰ Show member pathways Metabolism of lipids and lipoproteins⁶⁰ Metabolic pathways³⁴	7.5	APOA1, APOE, LIPC, LPL, PNLIP
14	Lipoprotein metabolism⁶⁰ Show member pathways Lipid digestion, mobilization, and transport⁶⁰ HDL-mediated lipid transport⁶⁰ Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis⁶⁰ LDL-mediated lipid transport⁶⁰ Chylomicron-mediated lipid transport⁶⁰ Digestion of dietary lipid⁶⁰ VLDL interactions⁶⁰ VLDL biosynthesis⁶⁰ VLDLR internalisation and degradation⁶⁰ Reelin signalling pathway⁶⁰	7.5	APOA1, APOE, LIPC, LPL, PNLIP

GO Terms for genes affiliated with Hepatic Lipase Deficiency

Sources:
¹⁹Gene Ontology
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Cellular components related to Hepatic Lipase Deficiency according to GeneCards Suite gene sharing:

id	Name	GO ID	Score	Top Affiliating Genes
1	endocytic vesicle lumen	GO:0071682	9.8	APOA1, APOE
2	extracellular vesicle	GO:1903561	9.5	APOA1, APOE
3	intermediate-density lipoprotein particle	GO:0034363	9.4	APOA1, APOE
4	low-density lipoprotein particle	GO:0034362	9.4	APOA1, APOE
5	endoplasmic reticulum lumen	GO:0005788	9.4	APOA1, APOE, LIPC
6	chylomicron	GO:0042627	9.3	APOA1, APOE, LPL
7	high-density lipoprotein particle	GO:0034364	9.0	APOA1, APOE, LIPC
8	extracellular space	GO:0005615	8.6	APOA1, APOE, LIPC, LPL
9	very-low-density lipoprotein particle	GO:0034361	8.5	APOA1, APOE, LPL
10	extracellular region	GO:0005576	8.3	APOA1, APOE, LIPC, LPL, PNLIP

Biological processes related to Hepatic Lipase Deficiency according to GeneCards Suite gene sharing:

(show all 32)

id	Name	GO ID	Score	Top Affiliating Genes
1	fatty acid biosynthetic process	GO:0006633	10.2	LIPC, LPL
2	lipid digestion	GO:0044241	10.2	LIPC, PNLIP
3	cholesterol transport	GO:0030301	10.1	APOA1, LIPC
4	regulation of lipoprotein lipase activity	GO:0051004	10.1	LIPC, LPL
5	phospholipid metabolic process	GO:0006644	10.0	APOA1, LPL
6	chylomicron remnant clearance	GO:0034382	9.9	APOE, LIPC
7	low-density lipoprotein particle remodeling	GO:0034374	9.8	APOE, LIPC
8	cholesterol efflux	GO:0033344	9.8	APOA1, APOE
9	chylomicron assembly	GO:0034378	9.8	APOA1, APOE
10	high-density lipoprotein particle assembly	GO:0034380	9.8	APOA1, APOE
11	high-density lipoprotein particle clearance	GO:0034384	9.8	APOA1, APOE
12	lipid transport	GO:0006869	9.7	APOA1, APOE
13	lipoprotein biosynthetic process	GO:0042158	9.7	APOA1, APOE
14	lipid catabolic process	GO:0016042	9.7	LIPC, LPL, PNLIP
15	negative regulation of inflammatory response	GO:0050728	9.7	APOA1, APOE
16	neuron projection regeneration	GO:0031102	9.7	APOA1, APOE
17	phospholipid efflux	GO:0033700	9.7	APOA1, APOE
18	positive regulation of cholesterol esterification	GO:0010873	9.7	APOA1, APOE
19	regulation of Cdc42 protein signal transduction	GO:0032489	9.6	APOA1, APOE
20	steroid metabolic process	GO:0008202	9.6	APOA1, APOE
21	triglyceride metabolic process	GO:0006641	9.3	APOE, LPL
22	cholesterol metabolic process	GO:0008203	9.3	APOA1, APOE, LIPC
23	high-density lipoprotein particle remodeling	GO:0034375	9.3	APOA1, APOE, LIPC
24	chylomicron remodeling	GO:0034371	9.2	APOA1, APOE, LPL
25	reverse cholesterol transport	GO:0043691	9.2	APOA1, APOE, LIPC
26	lipoprotein metabolic process	GO:0042157	9.2	APOA1, APOE, LPL
27	cholesterol homeostasis	GO:0042632	8.8	APOA1, APOE, LIPC, LPL
28	very-low-density lipoprotein particle remodeling	GO:0034372	8.7	APOE, LIPC, LPL
29	retinoid metabolic process	GO:0001523	8.6	APOA1, APOE, LPL, PNLIP
30	triglyceride catabolic process	GO:0019433	8.5	APOA1, APOE, LIPC, LPL
31	triglyceride homeostasis	GO:0070328	8.5	APOA1, APOE, LIPC, LPL
32	lipid metabolic process	GO:0006629	8.2	APOA1, APOE, LIPC, LPL, PNLIP

Molecular functions related to Hepatic Lipase Deficiency according to GeneCards Suite gene sharing:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	apolipoprotein binding	GO:0034185	10.1	LIPC, LPL
2	phospholipase activity	GO:0004620	10.0	LIPC, LPL
3	beta-amyloid binding	GO:0001540	9.7	APOA1, APOE
4	cholesterol binding	GO:0015485	9.7	APOA1, APOE
5	cholesterol transporter activity	GO:0017127	9.7	APOA1, APOE
6	carboxylic ester hydrolase activity	GO:0052689	9.6	LIPC, LPL, PNLIP
7	lipid transporter activity	GO:0005319	9.6	APOA1, APOE
8	lipoprotein particle binding	GO:0071813	9.6	APOA1, APOE
9	phosphatidylcholine-sterol O-acyltransferase activator activity	GO:0060228	9.6	APOA1, APOE
10	phospholipid binding	GO:0005543	9.4	APOA1, APOE
11	heparin binding	GO:0008201	9.2	APOE, LIPC, LPL
12	triglyceride lipase activity	GO:0004806	9.0	LIPC, LPL, PNLIP