MCID: HPT008
MIFTS: 42

Hepatic Tuberculosis malady

Categories: Skin diseases, Infectious diseases, Liver diseases

Aliases & Classifications for Hepatic Tuberculosis

Aliases & Descriptions for Hepatic Tuberculosis:

Name: Hepatic Tuberculosis 12 14
Tuberculosis, Hepatic 42 69
Tuberculosis of Liver 12
Tuberculosis Hepatic 52

Classifications:



External Ids:

Disease Ontology 12 DOID:407
MeSH 42 D014386
SNOMED-CT 64 186273003
UMLS 69 C0041313

Summaries for Hepatic Tuberculosis

Disease Ontology : 12 A gastrointestinal tuberculosis that involves infection located in liver, which results in the formation of tuberculous granulomas. The infection has symptom fever, has symptom anorexia, has symptom weight loss, has symptom abdominal pain and has symptom jaundice.

MalaCards based summary : Hepatic Tuberculosis, also known as tuberculosis, hepatic, is related to hepatitis and tuberculosis, and has symptoms including fever, anorexia and weight loss. An important gene associated with Hepatic Tuberculosis is ALPP (Alkaline Phosphatase, Placental), and among its related pathways/superpathways are NRF2 pathway and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Rifampin and Estradiol have been mentioned in the context of this disorder. Affiliated tissues include liver, skin and lung.

Related Diseases for Hepatic Tuberculosis

Diseases related to Hepatic Tuberculosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 106)
id Related Disease Score Top Affiliating Genes
1 hepatitis 10.4
2 tuberculosis 10.4
3 nondystrophic myotonia 10.2 ALB F2
4 freiberg's disease 10.2 ALB F2
5 jejunal neuroendocrine tumor 10.2 ALPP GPT
6 duane retraction syndrome 10.2 ALB F2
7 familial progressive hyperpigmentation 10.2 F2 GPT
8 chronic inflammatory demyelinating polyneuritis 10.2 ALB F2
9 angelucci's syndrome 10.2 ALB F2
10 ovarian papillary cystadenoma 10.2 ALB F2
11 myopia 10.2 ALB F2
12 infiltrating ureter transitional cell carcinoma 10.2 ALB F2
13 maxillary sinusitis 10.2 F2 GPT
14 eagle syndrome 10.2 ALB F2
15 atrophic vulva 10.2 ALB F2
16 ringed hair 10.2 GGT1 GPT
17 capillary hemangioma 10.2 ALB F2
18 tubular adenocarcinoma 10.1 F2 SMUG1
19 isolated growth hormone deficiency 10.1 ALB GPT
20 tolosa-hunt syndrome 10.1 GGT1 GGT2
21 rectum leiomyoma 10.1 F2 SMUG1
22 central nervous system rhabdomyosarcoma 10.1 ALB SMUG1
23 malignant visceral pleura tumor 10.1 GGT1 GGT2
24 bladder sarcoma 10.1 ALB GPT
25 chronic venous insufficiency 10.1 GGT1 GGT2
26 brain stem cancer 10.1 F2 SMUG1
27 campylobacteriosis 10.1 GGT1 GPT
28 autoimmune disease, multisystem, with facial dysmorphism 10.1 GGT1 GGT2
29 stenosis of lacrimal punctum 10.1 GGT1 GGT2
30 adenocarcinoma in situ 10.1 ALB SMUG1
31 alcoholic gastritis 10.1 ALB F2
32 venezuelan equine encephalitis 10.1 ALB SMUG1
33 ischemic optic neuropathy 10.1 ALB F2
34 artery disease 10.1 F2 SMUG1
35 hypertropia 10.1 ALB SMUG1
36 retina lymphoma 10.1 GGT1 GGT2
37 inferior myocardial infarction 10.1 ALPP SMUG1
38 rosacea 10.1 ALB ALPP GPT
39 female infertility of uterine origin 10.1 ALB F2 GPT
40 retinal arterial macroaneurysm with supravalvular pulmonic stenosis 10.1 ALB F2 GPT
41 acute monocytic leukemia 10.1 ALB F2 GPT
42 hereditary alpha tryptasemia syndrome 10.1 ALB F2 GPT
43 benign deep fibrous histiocytoma 10.1 ALB F2 GPT
44 pyelitis 10.1 ALB F2 GPT
45 fallopian tube leiomyosarcoma 10.1 ALB F2 GPT
46 congenital hypoplastic anemia 10.1 ALB F2 GPT
47 amelogenesis imperfecta 10.1 ALB F2 GPT
48 fiedler's myocarditis 10.1 ALB F2 GPT
49 anal fistula 10.1 ALB F2
50 chromosome 18 pericentric inversion 10.1 ALB SERPINA1

Graphical network of the top 20 diseases related to Hepatic Tuberculosis:



Diseases related to Hepatic Tuberculosis

Symptoms & Phenotypes for Hepatic Tuberculosis

Symptoms:

12
  • fever
  • anorexia
  • weight loss
  • abdominal pain
  • jaundice

Drugs & Therapeutics for Hepatic Tuberculosis

Drugs for Hepatic Tuberculosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 94)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Rifampin Approved Phase 4,Phase 3,Phase 2 13292-46-1 5458213 5381226
2
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3 50-28-2 5757 53477783
3
Ethinyl Estradiol Approved Phase 4,Phase 3 57-63-6 5991
4
Moxifloxacin Approved, Investigational Phase 4,Phase 3 354812-41-2, 151096-09-2 152946
5
Norgestimate Approved Phase 4,Phase 3 35189-28-7 6540478
6 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1
7 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
8 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3
9 Contraceptive Agents Phase 4,Phase 3
10 Contraceptives, Oral Phase 4,Phase 3
11 Contraceptives, Oral, Combined Phase 4,Phase 3
12 Estradiol 17 beta-cypionate Phase 4,Phase 3
13 Estradiol 3-benzoate Phase 4,Phase 3
14 Estradiol valerate Phase 4,Phase 3 979-32-8
15 Fluoroquinolones Phase 4,Phase 3
16 Norgestimate, ethinyl estradiol drug combination Phase 4,Phase 3
17 Polyestradiol phosphate Phase 4,Phase 3
18 Topoisomerase Inhibitors Phase 4,Phase 3
19
Efavirenz Approved, Investigational Phase 3 154598-52-4 64139
20
Lamivudine Approved, Investigational Phase 3 134678-17-4 60825
21
Nevirapine Approved Phase 3 129618-40-2 4463
22
Adalimumab Approved Phase 3 331731-18-1 16219006
23
Bedaquiline Approved Phase 3,Phase 1 843663-66-1
24
Ethambutol Approved Phase 2, Phase 3 74-55-5 3279 14052
25
Isoniazid Approved Phase 2, Phase 3, Phase 1 54-85-3 3767
26
Pyrazinamide Approved Phase 2, Phase 3 98-96-4 1046
27
Clofazimine Approved, Investigational Phase 3 2030-63-9 2794
28
Kanamycin Approved, Vet_approved Phase 3 8063-07-8, 59-01-8 6032
29
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
30
Ofloxacin Approved Phase 3 82419-36-1 4583
31 Antibiotics, Antitubercular Phase 3,Phase 2,Phase 1
32 Anti-HIV Agents Phase 3,Phase 2,Phase 1
33 Anti-Retroviral Agents Phase 3,Phase 2,Phase 1
34 Antitubercular Agents Phase 3,Phase 2,Phase 1
35 Antiviral Agents Phase 3,Phase 2,Phase 1
36 Cytochrome P-450 Enzyme Inhibitors Phase 3,Phase 2,Phase 1
37 Cytochrome P-450 CYP2C9 Inhibitors Phase 3
38 Cytochrome P-450 CYP3A Inducers Phase 3
39 Reverse Transcriptase Inhibitors Phase 3
40 Antibodies Phase 3
41 Antibodies, Monoclonal Phase 3
42 Anti-Inflammatory Agents Phase 3
43 Antirheumatic Agents Phase 3
44 Immunoglobulins Phase 3
45 Antimetabolites Phase 2, Phase 3, Phase 1
46 Liver Extracts Phase 2, Phase 3
47 Diarylquinolines Phase 3,Phase 1
48 Hypolipidemic Agents Phase 2, Phase 3, Phase 1
49 Lipid Regulating Agents Phase 2, Phase 3, Phase 1
50 Cytochrome P-450 CYP1A2 Inhibitors Phase 3

Interventional clinical trials:

(show all 18)
id Name Status NCT ID Phase
1 Pharmacokinetics and Safety of Moxifloxacin Terminated NCT01329250 Phase 4
2 Efficacy and Safety of Concomitant Use of Nevirapine and Rifampicin With HIV-TB Completed NCT01805258 Phase 3
3 Long-term Safety and Tolerability Study of Adalimumab in Subjects With Crohn's Disease Completed NCT00195715 Phase 3
4 Efficacy of HUEXC030 in Subjects With Pulmonary Tuberculosis Recruiting NCT02467608 Phase 2, Phase 3
5 The Evaluation of a Standard Treatment Regimen of Anti-tuberculosis Drugs for Patients With MDR-TB Recruiting NCT02409290 Phase 3
6 EARNEST Rifabutin Pharmacokinetics (PK) Substudy Unknown status NCT01663168 Phase 2
7 A Study of TMC207 in Patients With Moderately Impaired Hepatic Function Completed NCT01012284 Phase 1
8 Placebo-Controlled Trial of Safety and Efficacy of Thalidomide in Patients With Infections Due to Mycobacterium and/or HIV Completed NCT00002104 Phase 1
9 Pharmacokinetics and Safety of PA-824 in Subjects With Mild, Moderate, and Severe Hepatic Impairment to Matched, Non-Hepatically Impaired Subjects Suspended NCT02422524 Phase 1
10 Impact of Once-Weekly Rifapentine and Isoniazid on the Steady State Pharmacokinetics of Dolutegravir and Darunavir Boosted With Cobicistat in Healthy Volunteers Suspended NCT02771249 Phase 1
11 Effect of Prophylactic Use of Silymarin on Hepatotoxicity Induced by Anti-tuberculosis Drugs Unknown status NCT01436929
12 Investigation of the Effect of N Acetylcysteine Against Anti-Tuberculosis Drugs Induced Liver Toxicity Completed NCT00564642
13 A Retrospective Study on Drug Induced Liver Injury in China Completed NCT02407964
14 Evaluating Strategies to Reduce Mother-to-Child Transmission of HIV Infection in Populations Using Formula Feeding (PROMISE) Completed NCT01253538
15 Evaluating Strategies to Reduce Mother-to-Child Transmission of HIV Infection in Resource-Limited Countries Completed NCT01061151
16 Hepatitis B in Cystic Fibrosis and Latent Tuberculosis Respectively Recruiting NCT02605538
17 Glycosylated Ferritin in Macrophagic Activation Syndromes Recruiting NCT02143986
18 Clinical and Virological Outcome of European Patients Infected With HIV Enrolling by invitation NCT02699736

Search NIH Clinical Center for Hepatic Tuberculosis

Cochrane evidence based reviews: tuberculosis, hepatic

Genetic Tests for Hepatic Tuberculosis

Anatomical Context for Hepatic Tuberculosis

MalaCards organs/tissues related to Hepatic Tuberculosis:

39
Liver, Skin, Lung, Colon

The Foundational Model of Anatomy Ontology organs/tissues related to Hepatic Tuberculosis:

18
Liver

Publications for Hepatic Tuberculosis

Articles related to Hepatic Tuberculosis:

(show top 50) (show all 82)
id Title Authors Year
1
Localized Hepatic Tuberculosis with Imaging Changes Caused by the Progression of Tuberculosis. ( 26984077 )
2016
2
Erythema induratum of Bazin and PonAset's arthropathy as epiphenomena of hepatic tuberculosis. ( 26944370 )
2016
3
Isolated hepatic tuberculosis masquerading as hepatic metastasis in a patient with Ewing's sarcoma of fibula. ( 27146750 )
2016
4
Primary/local hepatic tuberculosis without dissemination. ( 25628318 )
2015
5
A rare case of isolated macronodular hepatic tuberculosis (Tuberculous) in an immunocompetent patient. ( 26564302 )
2015
6
Primary hepatic tuberculosis mimicking intrahepatic cholangiocarcinoma: report of two cases. ( 26236700 )
2015
7
A systematic review of hepatic tuberculosis with considerations in human immunodeficiency virus co-infection. ( 25943103 )
2015
8
Hepatic tuberculosis: a multimodality imaging review. ( 26499189 )
2015
9
Hepatic tuberculosis mimicking metastasis in a case of carcinoma sigmoid colon. ( 25949064 )
2015
10
Hepatic Tuberculosis Mimicking Biliary Cystadenoma: A Radiological Dilemma. ( 26504607 )
2015
11
Isolated hepatic tuberculosis: An uncommon presentation of a common culprit. ( 25031646 )
2014
12
Co-existence of hepatocellular carcinoma and hepatic tuberculosis. ( 24476016 )
2014
13
Multiple hepatic lesions in a case of isolated hepatic tuberculosis simulating metastases on 18F-FDG PET/CT imaging. ( 25088112 )
2014
14
Pulmonary tuberculosis combined with hepatic tuberculosis: a case report and literature review. ( 24865423 )
2014
15
Primary hepatic tuberculosis in immunocompetent adults: a UK case series. ( 25988061 )
2014
16
A case of multiple macronodular hepatic tuberculosis difficult to differentiate from hepatocellular carcinoma with intrahepatic metastasis: CT-guided fine needle aspiration biopsy confirmed the diagnosis. ( 25550879 )
2014
17
Isolated hepatic tuberculosis mimicking liver tumors in a dialysis patient. ( 25123829 )
2014
18
Isolated hepatic tuberculosis: a rare cause of hepatic mass lesions. ( 24918144 )
2014
19
Primary hepatic tuberculosis presenting as acute liver failure. ( 25988063 )
2014
20
Probable hepatic tuberculosis masquerading as Klatskin tumour in an immunocompetent patient. ( 24343799 )
2013
21
The liver Metastatic Adenocarcinoma of Colorectal Cancer With Synchronous Isolated Hepatic Tuberculosis. ( 23967026 )
2013
22
Primary isolated hepatic tuberculosis. ( 23673179 )
2013
23
Hepatic Tuberculosis Mimics Metastasis Revealed by 18F-FDG PET/CT. ( 24152632 )
2013
24
Diagnosis and treatment of hepatic tuberculosis: report of five cases and review of literature. ( 24179582 )
2013
25
Hepatic tuberculosis: a rare cause of fluorodeoxyglucose hepatic superscan with background suppression on positron emission tomography. ( 24347039 )
2013
26
Pseudo-tumoral hepatic tuberculosis discovered after surgical resection. ( 24765426 )
2012
27
Hepatic tuberculosis presenting with extreme hyperferritinemia masquerading as adult-onset Still's disease: a case report. ( 22788693 )
2012
28
Primary hepatic tuberculosis: a rare but fatal clinical entity if undiagnosed. ( 22575985 )
2012
29
Hepatic tuberculosis in a patient treated with infliximab. ( 21793022 )
2011
30
Pseudotumoral hepatic tuberculosis with pericardial abscess. ( 21045410 )
2010
31
The nodular form of hepatic tuberculosis: contrast-enhanced ultrasonographic findings with pathologic correlation. ( 20498462 )
2010
32
Corticosteroids in the treatment of hepatic tuberculosis: case report and review of the literature. ( 20092380 )
2010
33
Pseudo-tumoral hepatic tuberculosis: a report of two cases. ( 20306917 )
2010
34
Primary nodular hepatic tuberculosis mimicking hepatic neoplasia in an immunocompetent host. ( 20140362 )
2009
35
Radiological findings of isolated hepatic tuberculosis in a child with tubulointerstitial nephritis-uveitis syndrome. ( 19137283 )
2009
36
Primary hepatic tuberculosis in an immunocompetent patient: the Great Mimic. ( 19795040 )
2009
37
CT appearance of primary localized nodular hepatic tuberculosis in an immunocompetent patient. ( 18541946 )
2008
38
Granulomatous hepatitis: tuberculosis or not? ( 18241177 )
2008
39
Isolated hepatic tuberculosis. ( 20071827 )
2008
40
Isolated hepatic tuberculosis presenting as cystic-like and tumour-like mass lesions. ( 21490832 )
2008
41
Hepatic tuberculosis mimicking Klatskin tumor: a diagnostic dilemma. ( 18723964 )
2008
42
Macronodular hepatic tuberculosis necessitating hepatic resection: a diagnostic conundrum. ( 18031627 )
2007
43
Localized hepatic tuberculosis presenting as fever of unknown origin. ( 17293928 )
2006
44
Hepatic tuberculosis in absence of disseminated abdominal tuberculosis. ( 16531964 )
2006
45
Hypercalcemia in hepatic tuberculosis: a case report in Korea. ( 15827271 )
2005
46
Hepatic tuberculosis mimicking carcinoma gall bladder. ( 15778524 )
2005
47
Macronodular hepatic tuberculosis associated with portal vein thrombosis and portal hypertension. ( 16026440 )
2005
48
Hepatic tuberculosis presenting as cholestatic jaundice. A case report. ( 16737053 )
2005
49
Imaging diagnosis of 12 patients with hepatic tuberculosis. ( 15162540 )
2004
50
Isolated hepatic tuberculosis in a transplanted liver. ( 15522111 )
2004

Variations for Hepatic Tuberculosis

Expression for Hepatic Tuberculosis

Search GEO for disease gene expression data for Hepatic Tuberculosis.

Pathways for Hepatic Tuberculosis

GO Terms for Hepatic Tuberculosis

Cellular components related to Hepatic Tuberculosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.63 ALB F2 GGT1 GGT2 GPT SERPINA1
2 endoplasmic reticulum lumen GO:0005788 9.43 ALB F2 SERPINA1
3 extracellular space GO:0005615 9.35 ALB F2 GGT1 GPT SERPINA1
4 platelet alpha granule lumen GO:0031093 9.32 ALB SERPINA1
5 anchored component of external side of plasma membrane GO:0031362 8.62 GGT1 GGT2

Biological processes related to Hepatic Tuberculosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.43 ALB F2 SERPINA1
2 hemostasis GO:0007599 9.4 F2 SERPINA1
3 glutathione metabolic process GO:0006749 9.37 GGT1 GGT2
4 acute-phase response GO:0006953 9.32 F2 SERPINA1
5 leukotriene biosynthetic process GO:0019370 9.16 GGT1 GGT2
6 glutathione catabolic process GO:0006751 8.96 GGT1 GGT2
7 zymogen activation GO:0031638 8.62 GGT1 GGT2

Molecular functions related to Hepatic Tuberculosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 pyridoxal phosphate binding GO:0030170 9.16 ALB GPT
2 gamma-glutamyltransferase activity GO:0003840 8.96 GGT1 GGT2
3 glutathione hydrolase activity GO:0036374 8.62 GGT1 GGT2

Sources for Hepatic Tuberculosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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