MCID: HPT008
MIFTS: 46

Hepatic Tuberculosis malady

Infectious diseases, Gastrointestinal diseases, Liver diseases categories

Summaries for Hepatic Tuberculosis

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9Disease Ontology, 34MalaCards
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Disease Ontology:9 A gastrointestinal tuberculosis that involves infection located in liver, which results in the formation of tuberculous granulomas. the infection has symptom fever, has symptom anorexia, has symptom weight loss, has symptom abdominal pain and has symptom jaundice.

MalaCards: Hepatic Tuberculosis, also known as tuberculosis of liver, is related to hepatitis and obstructive jaundice, and has symptoms including anorexia, fever and weight loss. An important gene associated with Hepatic Tuberculosis is SERPINA1 (serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1), and among its related pathways are Complement and coagulation cascades and Response to elevated platelet cytosolic Ca2+. The compounds aminopyrine and cefotetan have been mentioned in the context of this disorder. Affiliated tissues include liver, liver and lung.

Aliases & Classifications for Hepatic Tuberculosis

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Sources:
9Disease Ontology, 46Novoseek, 63UMLS, 59SNOMED-CT, 36MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Gastrointestinal diseases, Liver diseases


Aliases & Descriptions:

hepatic tuberculosis 9
tuberculosis of liver 9
tuberculosis, hepatic 63
tuberculosis hepatic 46


External Ids:

Disease Ontology9 DOID:407
SNOMED-CT59 186273003
MeSH36 D014386

Related Diseases for Hepatic Tuberculosis

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Sources:
18GeneCards, 19GeneDecks
See all sources

Diseases related to Hepatic Tuberculosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 79)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis31.2ALPP, SERPINA1, GGT1, F2
2obstructive jaundice30.0GGT1, ALPP
3hypercalcemia30.0ALPP, ALB
4portal hypertension29.9ALB, F2, GGT1
5hypertension29.9F2, GGT1, ALB
6tuberculosis10.9
7gallbladder disease10.1GGT1
8dysfibrinogenemia10.1F2
9factor vii deficiency10.1F2
10hypersplenism10.1F2
11rickets10.1ALB, ALPP
12vascular disease10.1ALPP
13choledocholithiasis10.0ALPP, GGT1
14protein-losing enteropathy10.0SERPINA1, ALB
15secondary hyperparathyroidism of renal origin10.0ALB, ALPP
16skin disease10.0ALB, ALPP
17miliary tuberculosis10.0
18extrahepatic cholestasis10.0ALPP, GGT1
19hyperparathyroidism10.0ALB, ALPP
20cholelithiasis10.0ALPP, GGT1
21intrahepatic cholestasis10.0ALPP, GGT1
22fascioliasis10.0GGT1, ALPP
23congenital stationary night blindness, type 1f10.0ALPP, GGT1
24diarrhea10.0ALB, ALPP
25iga glomerulonephritis10.0SERPINA1, ALB
26hypersensitivity reaction type ii disease10.0ALPP, ALB
27cholangiocarcinoma10.0GGT1, ALPP
28nephrotic syndrome10.0ALB, SERPINA1
29esophageal varix10.0ALB, F2
30acute liver failure10.0F2, ALB
31hepatorenal syndrome10.0F2, ALB
32varicose veins10.0F2, ALB
33fatty liver disease10.0ALPP, GGT1
34hepatic encephalopathy10.0F2, ALB
35pulmonary embolism10.0ALB, F2
36hyperhomocysteinemia10.0ALB, F2
37peritonitis10.0F2, ALB
38hyperglycemia10.0ALB, SERPINA1
39connective tissue disease10.0F2, ALB
40stroke, ischemic10.0ALB, F2
41brain disease10.0F2, ALB
42autoimmune hepatitis10.0GGT1, F2
43cholangitis10.0ALPP, ALB, GGT1
44proteinuria10.0GGT1, ALB
45viral infectious disease10.0SERPINA1, GGT1, ALPP
46sickle cell anemia10.0
47granulomatous hepatitis10.0
48portal vein thrombosis10.0
49acquired immunodeficiency syndrome10.0
50adult-onset still's disease10.0

Graphical network of the top 20 diseases related to Hepatic Tuberculosis:



Diseases related to hepatic tuberculosis

Symptoms for Hepatic Tuberculosis

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Sources:
9Disease Ontology
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Symptoms:

9
  • anorexia
  • fever
  • weight loss
  • abdominal pain
  • jaundice

Drugs & Therapeutics for Hepatic Tuberculosis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Hepatic Tuberculosis

Drug clinical trials:

Search ClinicalTrials for Hepatic Tuberculosis

Search NIH Clinical Center for Hepatic Tuberculosis

Search CenterWatch for Hepatic Tuberculosis

Genetic Tests for Hepatic Tuberculosis

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Anatomical Context for Hepatic Tuberculosis

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Sources:
34MalaCards, 15FMA
See all sources

MalaCards organs/tissues related to Hepatic Tuberculosis:

34
Liver, Lung

FMA organs/tissues related to Hepatic Tuberculosis:

15
Liver

Animal Models for Hepatic Tuberculosis or affiliated genes

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Publications for Hepatic Tuberculosis

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Sources:
53PubMed
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Articles related to Hepatic Tuberculosis:

(show top 50)    (show all 62)
idTitleAuthorsYear
1
Probable hepatic tuberculosis masquerading as Klatskin tumour in an immunocompetent patient. (24343799)
2013
2
Primary isolated hepatic tuberculosis. (23673179)
2013
3
The liver Metastatic Adenocarcinoma of Colorectal Cancer With Synchronous Isolated Hepatic Tuberculosis. (23967026)
2013
4
Hepatic tuberculosis: a rare cause of fluorodeoxyglucose hepatic superscan with background suppression on positron emission tomography. (24347039)
2013
5
Diagnosis and treatment of hepatic tuberculosis: report of five cases and review of literature. (24179582)
2013
6
Hepatic Tuberculosis Mimics Metastasis Revealed by 18F-FDG PET/CT. (24152632)
2013
7
Primary hepatic tuberculosis: a rare but fatal clinical entity if undiagnosed. (22575985)
2012
8
Hepatic tuberculosis in a patient treated with infliximab. (21793022)
2011
9
Pseudo-tumoral hepatic tuberculosis: a report of two cases. (20306917)
2010
10
The nodular form of hepatic tuberculosis: contrast-enhanced ultrasonographic findings with pathologic correlation. (20498462)
2010
11
Corticosteroids in the treatment of hepatic tuberculosis: case report and review of the literature. (20092380)
2010
12
Primary nodular hepatic tuberculosis mimicking hepatic neoplasia in an immunocompetent host. (20140362)
2009
13
Primary hepatic tuberculosis in an immunocompetent patient: the Great Mimic. (19795040)
2009
14
Granulomatous hepatitis: tuberculosis or not? (18241177)
2008
15
CT appearance of primary localized nodular hepatic tuberculosis in an immunocompetent patient. (18541946)
2008
16
Isolated hepatic tuberculosis presenting as cystic-like and tumour-like mass lesions. (21490832)
2008
17
Isolated hepatic tuberculosis. (20071827)
2008
18
Macronodular hepatic tuberculosis necessitating hepatic resection: a diagnostic conundrum. (18031627)
2007
19
Localized hepatic tuberculosis presenting as fever of unknown origin. (17293928)
2006
20
Hepatic tuberculosis in absence of disseminated abdominal tuberculosis. (16531964)
2006
21
Hypercalcemia in hepatic tuberculosis: a case report in Korea. (15827271)
2005
22
Hepatic tuberculosis mimicking carcinoma gall bladder. (15778524)
2005
23
Hepatic tuberculosis presenting as cholestatic jaundice. A case report. (16737053)
2005
24
Imaging diagnosis of 12 patients with hepatic tuberculosis. (15162540)
2004
25
Isolated hepatic tuberculosis in a transplanted liver. (15522111)
2004
26
The nodular form of hepatic tuberculosis: a review with five additional new cases. (14600128)
2003
27
Localized hepatic tuberculosis. (14962708)
2003
28
Clinical spectrum of hepatic tuberculosis: comparison between immunocompetent and immunocompromised hosts. (12930021)
2003
29
Hepatic tuberculosis--a case report. (12797646)
2002
30
Computed tomography and angiography in hepatic tuberculosis mimicking liver tumor. (11573902)
2001
31
Miliary hepatic tuberculosis not associated with splenic or lung involvement. A case report. (11016770)
2000
32
Isolated hepatic tuberculosis: report of five cases and review of the literature. (10398910)
1999
33
Hepatic tuberculosis: comparison of miliary and local form. (7744492)
1995
34
Nodular form of local hepatic tuberculosis: case report. (7714939)
1995
35
The "cluster" sign in macronodular hepatic tuberculosis: CT features. (8419431)
1993
36
Primary hepatic tuberculosis in homozygous alpha-1-antitrypsin deficiency. (1562749)
1992
37
The nodular form of local hepatic tuberculosis. A review. (2157746)
1990
38
Macronodular hepatic tuberculosis in a child: computed tomographic appearances. (2400887)
1990
39
Primary macronodular hepatic tuberculosis: US and CT appearances. (2210202)
1990
40
Hepatic tuberculosis; a rare case of bleeding gastric varices. (2238132)
1990
41
Isolated hepatic tuberculosis with scrofuloderma. (3671278)
1987
42
A prospective study of hepatic tuberculosis in 41 black patients. (3659266)
1987
43
Local hepatic tuberculosis, the cause of a painful hepatic mass: case report and review of the literature. (3096551)
1986
44
Simultaneous hepatic tuberculosis, cirrhosis and hepatoma. A case report. (6320473)
1983
45
Hepatic tuberculosis simulating hepatic amoebiasis. (6671942)
1983
46
Spleno-hepatic tuberculosis due to Mycobacterium kansasii. (979821)
1976
47
Hepatic tuberculosis with haemosiderosis. (1052798)
1976
48
An unusual case of hemobilia. Hepatic tuberculosis with hemorrhage. (16097285)
1967
49
CLINICALLY ISOLATED HEPATIC TUBERCULOSIS]. (14149344)
1964
50
Hepatic tuberculosis in a patient with sickle-cell anemia who died of fatal post-transfusion hepatitis. (13031044)
1953

Variations for Hepatic Tuberculosis

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Expression for genes affiliated with Hepatic Tuberculosis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Hepatic Tuberculosis

Search GEO for disease gene expression data for Hepatic Tuberculosis.

Pathways for genes affiliated with Hepatic Tuberculosis

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Sources:
51PathCards, 31KEGG, 39NCBI BioSystems Database, 56Reactome, 13EMD Millipore
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Pathways related to Hepatic Tuberculosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Complement Activation, Classical Pathway39
Complement and Coagulation Cascades39
9.5F2, SERPINA1
2
Show member pathways
9.4SERPINA1, ALB
39.4SERPINA1, ALB
49.3ALB, F2
5
Show member pathways
8.9ALB, F2, SERPINA1
6
Show member pathways
thioredoxin pathway39
8.8F2, ALB, GGT1

Compounds for genes affiliated with Hepatic Tuberculosis

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Sources:
46Novoseek, 12DrugBank, 52PharmGKB, 30IUPHAR, 25HMDB, 3BitterDB, 62Tocris Bioscience
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Compounds related to Hepatic Tuberculosis according to GeneCards/GeneDecks:

(show top 50)    (show all 80)
idCompoundScoreTop Affiliating Genes
1aminopyrine469.8GGT1, F2
2cefotetan46 1210.8F2, ALB
3dextran 70469.7F2, ALB
4terlipressin46 1210.7ALB, F2
5hepaplastin469.7ALB, F2
6cefoperazone46 1210.7F2, ALB
7oxcarbazepine46 52 1211.7GGT1, ALB
8gamma globulin469.7GGT1, ALB
9acenocoumarol46 52 1211.7ALB, F2
10phenprocoumon46 52 1211.7F2, ALB
11hydroxyethyl starch469.7ALB, F2
12amiodarone46 52 30 1212.7F2, GGT1
13ethacrynic acid46 1210.6ALB, GGT1
14diisopropylfluorophosphate469.6ALB, SERPINA1
15l-tryptophan52 30 46 25 1213.6GGT1, ALB
16alpha lipoic acid469.5SERPINA1, GGT1
17propylthiouracil46 3 1211.4GGT1, ALPP
18diflunisal46 1210.4ALB, ALPP
19phenylbutazone46 1210.3F2, SERPINA1, ALB
20antipyrine46 1210.3GGT1, F2, ALB
21cellulose acetate469.2ALB, ALPP
22vitamin a46 25 1211.2GGT1, ALB, SERPINA1
23hyaluronic acid46 2510.2F2, ALB, GGT1
24vitamin b6469.1ALPP, ALB
25silymarin469.1GGT1, F2
26fibrinogen469.1SERPINA1, F2, ALB
27methotrexate52 46 1211.1F2, ALB, GGT1
28ursodeoxycholic acid46 25 1211.0F2, ALPP, GGT1
2925-hydroxyvitamin d469.0ALPP, ALB
30bezafibrate46 30 1211.0ALPP, GGT1
31iron46 2510.0GGT1, SERPINA1, ALB
32sevoflurane52 46 1211.0ALPP, ALB, GGT1
33isoflurane52 46 1210.9ALPP, ALB, GGT1
34phosphorus468.9GGT1, ALPP, ALB
35pyridoxal 5-phosphate468.9GGT1, ALPP, ALB
36phenytoin46 52 30 1211.9ALB, ALPP, GGT1
37vitamin b12468.9ALPP, ALB, GGT1
38polyethylene glycol468.9F2, ALPP, ALB
39thyroxine46 259.9GGT1, ALB, ALPP
40tamoxifen46 52 30 1211.9ALPP, F2, GGT1
41calcitriol46 62 25 1211.9ALB, F2, ALPP
42ascorbic acid46 259.5SERPINA1, ALB, ALPP, GGT1
43cholesterol46 30 25 1211.5GGT1, SERPINA1, ALB, ALPP
44lactate468.4GGT1, ALPP, F2, ALB
45aspartate468.4GGT1, F2, ALPP, ALB
46alanine468.4ALB, ALPP, F2, GGT1
47cysteine468.4ALB, GGT1, ALPP, SERPINA1
48serine468.2ALPP, GGT1, SERPINA1, F2
49creatinine468.0GGT1, ALPP, F2, SERPINA1, ALB
50heparin46 30 25 1211.0GGT1, ALB, ALPP, SERPINA1, F2

GO Terms for genes affiliated with Hepatic Tuberculosis

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Sources:
17Gene Ontology
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Cellular components related to Hepatic Tuberculosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.3ALB, SERPINA1
2blood microparticleGO:0725629.0ALB, F2
3extracellular spaceGO:0056158.9ALB, SERPINA1, F2

Biological processes related to Hepatic Tuberculosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1acute-phase responseGO:0069539.4SERPINA1, F2
2platelet degranulationGO:0025769.4SERPINA1, ALB
3platelet activationGO:0301688.9F2, SERPINA1, ALB
4blood coagulationGO:0075968.6F2, SERPINA1, ALB

Products for genes affiliated with Hepatic Tuberculosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hepatic Tuberculosis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet