MCID: HPT008
MIFTS: 41

Hepatic Tuberculosis malady

Liver category

Summaries for Hepatic Tuberculosis

Sources:
8Disease Ontology, 33MalaCards
See all sources

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Disease Ontology:8 A gastrointestinal tuberculosis that involves infection located in liver, which results in the formation of tuberculous granulomas. the infection has symptom fever, has symptom anorexia, has symptom weight loss, has symptom abdominal pain and has symptom jaundice.

MalaCards: Hepatic Tuberculosis, also known as tuberculosis of liver, is related to tuberculosis and acquired immunodeficiency syndrome, and has symptoms including anorexia, fever and weight loss. An important gene associated with Hepatic Tuberculosis is SERPINA1 (serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1), and among its related pathways are Complement and coagulation cascades and Platelet degranulation . The compounds heparin and vitamin a have been mentioned in the context of this disorder. Affiliated tissues include liver, liver and lymph node.

Aliases & Classifications for Hepatic Tuberculosis

Sources:
8Disease Ontology, 45Novoseek, 61UMLS, 35MeSH, 57SNOMED-CT
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Liver


Aliases & Descriptions:

hepatic tuberculosis 8
tuberculosis of liver 8
tuberculosis, hepatic 61
tuberculosis hepatic 45


External Ids:

Disease Ontology8 DOID:407
SNOMED-CT57 186273003
MeSH35 D014386

Related Diseases for Hepatic Tuberculosis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Hepatic Tuberculosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 127)
idRelated DiseaseScoreTop Affiliating Genes
1tuberculosis31.3ALB, SERPINA1
2acquired immunodeficiency syndrome29.9ALB
3hepatitis a29.9F2
4portal vein thrombosis29.9F2
5colorectal cancer29.9ALPP, SERPINA1
6obstructive jaundice29.9GGT1, ALPP
7adenocarcinoma29.9GGT1, SERPINA1
8portal hypertension29.9F2, GGT1, ALB
9hepatitis c29.9SERPINA1, GGT1, F2
10miliary tuberculosis10.1
11renal tuberculosis10.0
12hyperthyroidism10.0ALPP
13hypophosphatemia10.0ALPP
14acute pancreatitis10.0SERPINA1
15inflammatory bowel disease10.0ALPP
16periodontal disease10.0ALPP
17crohn's disease10.0ALB
18rheumatoid arthritis10.0SERPINA1
19malaria10.0ALB
20metabolic acidosis10.0ALB
21respiratory failure10.0SERPINA1
22hemochromatosis10.0SERPINA1
23ulcerative colitis10.0ALB
24hyperphosphatemia10.0ALPP
25stomach cancer10.0SERPINA1
26melanoma10.0SERPINA1
27choriocarcinoma10.0ALPP
28lung cancer10.0ALB
29biliary atresia10.0GGT1
30gallbladder disease10.0GGT1
31hypercholesterolemia10.0GGT1
32protein-energy malnutrition10.0ALB
33oral cancer10.0GGT1
34vascular disease10.0ALPP
35coronary heart disease10.0GGT1
36gingivitis10.0ALPP
37short bowel syndrome10.0ALB
38acute myocardial infarction10.0SERPINA1
39osteogenesis imperfecta10.0ALPP
40pulmonary disease, chronic obstructive10.0SERPINA1
41peripheral vascular disease10.0ALB
42pulmonary eosinophilia10.0GGT1
43adenoma10.0GGT1
44ovarian hyperstimulation syndrome10.0ALB
45obesity10.0GGT1
46alpha 1-antitrypsin deficiency10.0SERPINA1
47rickets10.0ALPP
48hypersplenism10.0F2
49dysfibrinogenemia10.0F2
50thromboembolism10.0F2

Graphical network of the top 20 diseases related to Hepatic Tuberculosis:



Diseases related to hepatic tuberculosis

Clinical Features for Hepatic Tuberculosis

Sources:
8Disease Ontology
See all sources


Symptoms:

8 (see all 5)
  • anorexia
  • fever
  • weight loss
  • jaundice
  • abdominal pain

Drugs & Therapeutics for Hepatic Tuberculosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Hepatic Tuberculosis

Drug clinical trials:

Search ClinicalTrials for Hepatic Tuberculosis

Search NIH Clinical Center for Hepatic Tuberculosis

Search CenterWatch for Hepatic Tuberculosis

Genetic Tests for Hepatic Tuberculosis

Anatomical Context for Hepatic Tuberculosis

Sources:
14FMA, 33MalaCards
See all sources

MalaCards organs/tissues related to Hepatic Tuberculosis:

33
Liver, Lymph node, Lung, Monocytes

FMA organs/tissues related to Hepatic Tuberculosis:

14
Liver

Animal Models for Hepatic Tuberculosis or affiliated genes

Sources:
28inGenious Targeting Laboratory
See all sources

Publications for Hepatic Tuberculosis

Sources:
51PubMed
See all sources

Articles related to Hepatic Tuberculosis:

(show top 50)    (show all 79)
idTitleAuthorsYear
1
Probable hepatic tuberculosis masquerading as Klatskin tumour in an immunocompetent patient. (24343799)
2013
2
Primary isolated hepatic tuberculosis. (23673179)
2013
3
Atypical presentation of miliary tuberculosis with hepatic involvement early after renal transplantation. (23142602)
2013
4
The liver Metastatic Adenocarcinoma of Colorectal Cancer With Synchronous Isolated Hepatic Tuberculosis. (23967026)
2013
5
Hepatic Tuberculosis Mimics Metastasis Revealed by 18F-FDG PET/CT. (24152632)
2013
6
Hepatic tuberculosis in a patient treated with infliximab. (21793022)
2011
7
Relationship between the polymorphisms of UGT1A6 genes and anti-tuberculosis drug induced hepatic-injury]. (21586239)
2011
8
Radiological findings of isolated hepatic tuberculosis in a child with tubulointerstitial nephritis-uveitis syndrome. (19137283)
2009
9
CT appearance of primary localized nodular hepatic tuberculosis in an immunocompetent patient. (18541946)
2008
10
Isolated hepatic tuberculosis. (20071827)
2008
11
Hepatic tuberculosis mimicking Klatskin tumor: a diagnostic dilemma. (18723964)
2008
12
Macronodular hepatic tuberculosis necessitating hepatic resection: a diagnostic conundrum. (18031627)
2007
13
Localized hepatic tuberculosis presenting as fever of unknown origin. (17293928)
2006
14
Renal tuberculosis simulating xanthogranulomatous pyelonephritis with contagious hepatic involvement. (16448435)
2006
15
Case report of lymph nodal, hepatic and splenic tuberculosis in an HIV-positive patient. (16878268)
2006
16
Hypercalcemia in hepatic tuberculosis: a case report in Korea. (15827271)
2005
17
Hepatic tuberculosis mimicking carcinoma gall bladder. (15778524)
2005
18
Hepatic tuberculosis presenting as cholestatic jaundice. A case report. (16737053)
2005
19
The nodular form of hepatic tuberculosis: a review with five additional new cases. (14600128)
2003
20
Localized hepatic tuberculosis. (14962708)
2003
21
Clinical spectrum of hepatic tuberculosis: comparison between immunocompetent and immunocompromised hosts. (12930021)
2003
22
Pseudotumoral hepatic tuberculosis. (12971980)
2003
23
Hepatic tuberculosis--a case report. (12797646)
2002
24
Hepatic tuberculosis--a case report. (12675187)
2002
25
Computed tomography and angiography in hepatic tuberculosis mimicking liver tumor. (11573902)
2001
26
Effects of the enterosorbent SUMS-1 on isoniazid pharmacokinetics and lipid peroxidation in patients with pulmonary tuberculosis and drug-induced hepatic lesions]. (11508231)
2001
27
Isolated hepatic tuberculosis: report of five cases and review of the literature. (10398910)
1999
28
Abdominal tuberculosis involving hepatic hilar lymph nodes. (9600377)
1998
29
Fatal hepatic failure caused by miliary tuberculosis in a hemodialysis patient: case report. (9554822)
1998
30
Abdominal tuberculosis involving hepatic hilar lymph nodes. A cause of portal vein thrombosis and portal hypertension. (9412974)
1997
31
Hepatic tuberculosis: comparison of miliary and local form. (7744492)
1995
32
Nodular form of local hepatic tuberculosis: case report. (7714939)
1995
33
Recurrent Salmonella enteritidis sepsis and hepatic tuberculosis. (7672664)
1995
34
The "cluster" sign in macronodular hepatic tuberculosis: CT features. (8419431)
1993
35
Miliary tuberculosis presenting as fever and jaundice with hepatic failure. (1985084)
1991
36
Focal hepatic tuberculosis in a patient with acquired immunodeficiency syndrome. (2000536)
1991
37
The nodular form of local hepatic tuberculosis. A review. (2157746)
1990
38
Macronodular hepatic tuberculosis in a child: computed tomographic appearances. (2400887)
1990
39
Budd Chiari syndrome in a child with hepatic tuberculosis. (2807366)
1989
40
Atypical hepatic tuberculosis presenting as obstructive jaundice. (3421231)
1988
41
Isolated hepatic tuberculosis with scrofuloderma. (3671278)
1987
42
Granulocytopenia, jaundice and hepatic coma with disseminated tuberculosis. (3793681)
1986
43
Local hepatic tuberculosis, the cause of a painful hepatic mass: case report and review of the literature. (3096551)
1986
44
Simultaneous hepatic tuberculosis, cirrhosis and hepatoma. A case report. (6320473)
1983
45
Spleno-hepatic tuberculosis due to Mycobacterium kansasii. (979821)
1976
46
Hepatic involvement in abdominal tuberculosis (a clinical, biochemical and histopathological study). (4654916)
1972
47
An unusual case of hemobilia. Hepatic tuberculosis with hemorrhage. (16097285)
1967
48
DIAGNOSTIC PROBLEMS IN HEPATIC TUBERCULOSIS. (14225675)
1964
49
Hepatic involvement in extrapulmonary tuberculosis; histologic and functional characteristics. (13661188)
1959
50
Hepatic tuberculosis in a patient with sickle-cell anemia who died of fatal post-transfusion hepatitis. (13031044)
1953

Genetic Variations for Hepatic Tuberculosis

Expression for genes affiliated with Hepatic Tuberculosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Hepatic Tuberculosis

Search GEO for disease gene expression data for Hepatic Tuberculosis.

Pathways for genes affiliated with Hepatic Tuberculosis

Sources:
30KEGG, 38NCBI BioSystems Database, 54Reactome, 12EMD Millipore
See all sources

Pathways related to Hepatic Tuberculosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.5SERPINA1, F2
2
Hide members
9.4ALB, SERPINA1
39.4SERPINA1, ALB
49.3ALB, F2
5
Hide members
8.9ALB, SERPINA1, F2
68.8ALB, GGT1, F2

Compounds for genes affiliated with Hepatic Tuberculosis

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB, 60Tocris Bioscience
See all sources

Compounds related to Hepatic Tuberculosis according to GeneCards/GeneDecks:

(show top 50)    (show all 59)
idCompoundScoreTop Affiliating Genes
1heparin45 29 11 2413.5SERPINA1
2vitamin a45 11 2412.3SERPINA1
3diisopropylfluorophosphate4510.3SERPINA1
4aminopyrine459.8F2, GGT1
5cefotetan45 1110.8ALB, F2
6dextran 70459.7ALB, F2
7oxcarbazepine45 1110.7GGT1, ALB
8terlipressin45 1110.7F2, ALB
9hepaplastin459.7F2, ALB
10cefoperazone45 1110.7ALB, F2
11gamma globulin459.7GGT1, ALB
12acenocoumarol45 50 1111.7ALB, F2
13amiodarone45 50 29 1112.7GGT1, F2
14phenprocoumon45 50 1111.7F2, ALB
15hydroxyethyl starch459.7F2, ALB
16l-tryptophan45 29 11 2412.6ALB, GGT1
17alpha lipoic acid459.5GGT1, SERPINA1
18silymarin459.5F2, GGT1
19diflunisal45 1110.4ALPP, ALB
20serine459.4ALPP
21phenylbutazone45 1110.3ALB, SERPINA1, F2
22bezafibrate45 29 1111.3ALPP, GGT1
23antipyrine45 1110.3ALB, GGT1, F2
24cellulose acetate459.3ALB, ALPP
25vitamin b6459.2ALPP, ALB
26mycophenolate mofetil45 50 1111.2ALB, GGT1
2725-hydroxyvitamin d459.2ALB, ALPP
28hyaluronic acid45 2410.2ALB, GGT1, F2
29fibrinogen459.1F2, SERPINA1, ALB
30carbamazepine45 50 1111.1ALPP, GGT1
31methotrexate45 50 1111.1ALB, GGT1, F2
32ursodeoxycholic acid45 11 2411.0F2, GGT1, ALPP
33iron45 2410.0GGT1, SERPINA1, ALB
34sevoflurane45 1110.0ALB, ALPP, GGT1
35isoflurane45 119.9GGT1, ALPP, ALB
36phosphorus458.9ALB, ALPP, GGT1
37pyridoxal 5-phosphate458.9ALB, ALPP, GGT1
38phenytoin45 50 29 1111.9GGT1, ALPP, ALB
39vitamin b12458.9ALB, ALPP, GGT1
40polyethylene glycol458.9ALB, ALPP, F2
41tamoxifen45 50 29 1111.9ALPP, GGT1, F2
42thyroxine45 249.9ALB, ALPP, GGT1
43calcitriol45 60 11 2411.8ALB, ALPP, F2
44ascorbic acid45 249.5ALB, ALPP, SERPINA1, GGT1
45cholesterol45 29 11 2411.4GGT1, SERPINA1, ALPP, ALB
46lactate458.4F2, GGT1, ALPP, ALB
47aspartate458.4F2, GGT1, ALPP, ALB
48cysteine458.4GGT1, SERPINA1, ALPP, ALB
49alanine458.3F2, GGT1, ALPP, ALB
50creatinine458.0ALB, ALPP, SERPINA1, GGT1, F2

GO Terms for genes affiliated with Hepatic Tuberculosis

Sources:
16Gene Ontology
See all sources

Cellular components related to Hepatic Tuberculosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.4ALB, SERPINA1

Biological processes related to Hepatic Tuberculosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1acute-phase responseGO:0069539.4SERPINA1, F2
2platelet degranulationGO:0025769.4ALB, SERPINA1
3platelet activationGO:0301688.9ALB, SERPINA1, F2
4blood coagulationGO:0075968.6F2, SERPINA1, ALB

Products for genes affiliated with Hepatic Tuberculosis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hepatic Tuberculosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet