MCID: HPT008
MIFTS: 46

Hepatic Tuberculosis malady

Infectious diseases, Gastrointestinal diseases, Liver diseases categories
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Summaries for Hepatic Tuberculosis

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8Disease Ontology, 33MalaCards
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Disease Ontology:8 A gastrointestinal tuberculosis that involves infection located in liver, which results in the formation of tuberculous granulomas. the infection has symptom fever, has symptom anorexia, has symptom weight loss, has symptom abdominal pain and has symptom jaundice.

MalaCards: Hepatic Tuberculosis, also known as tuberculosis of liver, is related to hepatitis and obstructive jaundice, and has symptoms including anorexia, fever and weight loss. An important gene associated with Hepatic Tuberculosis is SERPINA1 (serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1), and among its related pathways are Complement and coagulation cascades and Response to elevated platelet cytosolic Ca2+. The compounds aminopyrine and cefotetan have been mentioned in the context of this disorder. Affiliated tissues include liver, liver and lung.

Aliases & Classifications for Hepatic Tuberculosis

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Sources:
8Disease Ontology, 45Novoseek, 62UMLS, 58SNOMED-CT, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Gastrointestinal diseases, Liver diseases


Aliases & Descriptions:

hepatic tuberculosis 8
tuberculosis of liver 8
tuberculosis, hepatic 62
tuberculosis hepatic 45


External Ids:

Disease Ontology8 DOID:407
SNOMED-CT58 186273003
MeSH35 D014386

Related Diseases for Hepatic Tuberculosis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Hepatic Tuberculosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 79)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis31.2ALPP, SERPINA1, GGT1, F2
2obstructive jaundice30.0GGT1, ALPP
3hypercalcemia30.0ALPP, ALB
4portal hypertension29.9ALB, F2, GGT1
5hypertension29.9F2, GGT1, ALB
6tuberculosis10.9
7gallbladder disease10.1GGT1
8dysfibrinogenemia10.1F2
9factor vii deficiency10.1F2
10hypersplenism10.1F2
11rickets10.1ALB, ALPP
12vascular disease10.1ALPP
13choledocholithiasis10.0ALPP, GGT1
14protein-losing enteropathy10.0SERPINA1, ALB
15secondary hyperparathyroidism of renal origin10.0ALB, ALPP
16skin disease10.0ALB, ALPP
17miliary tuberculosis10.0
18extrahepatic cholestasis10.0ALPP, GGT1
19hyperparathyroidism10.0ALB, ALPP
20cholelithiasis10.0ALPP, GGT1
21intrahepatic cholestasis10.0ALPP, GGT1
22fascioliasis10.0GGT1, ALPP
23congenital stationary night blindness, type 1f10.0ALPP, GGT1
24diarrhea10.0ALB, ALPP
25iga glomerulonephritis10.0SERPINA1, ALB
26hypersensitivity reaction type ii disease10.0ALPP, ALB
27cholangiocarcinoma10.0GGT1, ALPP
28nephrotic syndrome10.0ALB, SERPINA1
29esophageal varix10.0ALB, F2
30acute liver failure10.0F2, ALB
31hepatorenal syndrome10.0F2, ALB
32varicose veins10.0F2, ALB
33fatty liver disease10.0ALPP, GGT1
34hepatic encephalopathy10.0F2, ALB
35pulmonary embolism10.0ALB, F2
36hyperhomocysteinemia10.0ALB, F2
37peritonitis10.0F2, ALB
38hyperglycemia10.0ALB, SERPINA1
39connective tissue disease10.0F2, ALB
40stroke, ischemic10.0ALB, F2
41brain disease10.0F2, ALB
42autoimmune hepatitis10.0GGT1, F2
43cholangitis10.0ALPP, ALB, GGT1
44proteinuria10.0GGT1, ALB
45viral infectious disease10.0SERPINA1, GGT1, ALPP
46sickle cell anemia10.0
47granulomatous hepatitis10.0
48portal vein thrombosis10.0
49acquired immunodeficiency syndrome10.0
50adult-onset still's disease10.0

Graphical network of the top 20 diseases related to Hepatic Tuberculosis:



Diseases related to hepatic tuberculosis

Symptoms for Hepatic Tuberculosis

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Sources:
8Disease Ontology
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Symptoms:

8
  • anorexia
  • fever
  • weight loss
  • abdominal pain
  • jaundice

Drugs & Therapeutics for Hepatic Tuberculosis

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Hepatic Tuberculosis

Search NIH Clinical Center for Hepatic Tuberculosis

Genetic Tests for Hepatic Tuberculosis

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Anatomical Context for Hepatic Tuberculosis

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Sources:
33MalaCards, 14FMA
See all sources

MalaCards organs/tissues related to Hepatic Tuberculosis:

33
Liver, Lung

FMA organs/tissues related to Hepatic Tuberculosis:

14
Liver

Animal Models for Hepatic Tuberculosis or affiliated genes

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Publications for Hepatic Tuberculosis

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Sources:
52PubMed
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Articles related to Hepatic Tuberculosis:

(show top 50)    (show all 62)
idTitleAuthorsYear
1
Probable hepatic tuberculosis masquerading as Klatskin tumour in an immunocompetent patient. (24343799)
2013
2
Primary isolated hepatic tuberculosis. (23673179)
2013
3
The liver Metastatic Adenocarcinoma of Colorectal Cancer With Synchronous Isolated Hepatic Tuberculosis. (23967026)
2013
4
Hepatic tuberculosis: a rare cause of fluorodeoxyglucose hepatic superscan with background suppression on positron emission tomography. (24347039)
2013
5
Diagnosis and treatment of hepatic tuberculosis: report of five cases and review of literature. (24179582)
2013
6
Hepatic Tuberculosis Mimics Metastasis Revealed by 18F-FDG PET/CT. (24152632)
2013
7
Primary hepatic tuberculosis: a rare but fatal clinical entity if undiagnosed. (22575985)
2012
8
Hepatic tuberculosis in a patient treated with infliximab. (21793022)
2011
9
Pseudo-tumoral hepatic tuberculosis: a report of two cases. (20306917)
2010
10
The nodular form of hepatic tuberculosis: contrast-enhanced ultrasonographic findings with pathologic correlation. (20498462)
2010
11
Corticosteroids in the treatment of hepatic tuberculosis: case report and review of the literature. (20092380)
2010
12
Primary nodular hepatic tuberculosis mimicking hepatic neoplasia in an immunocompetent host. (20140362)
2009
13
Primary hepatic tuberculosis in an immunocompetent patient: the Great Mimic. (19795040)
2009
14
Granulomatous hepatitis: tuberculosis or not? (18241177)
2008
15
CT appearance of primary localized nodular hepatic tuberculosis in an immunocompetent patient. (18541946)
2008
16
Isolated hepatic tuberculosis presenting as cystic-like and tumour-like mass lesions. (21490832)
2008
17
Isolated hepatic tuberculosis. (20071827)
2008
18
Macronodular hepatic tuberculosis necessitating hepatic resection: a diagnostic conundrum. (18031627)
2007
19
Localized hepatic tuberculosis presenting as fever of unknown origin. (17293928)
2006
20
Hepatic tuberculosis in absence of disseminated abdominal tuberculosis. (16531964)
2006
21
Hypercalcemia in hepatic tuberculosis: a case report in Korea. (15827271)
2005
22
Hepatic tuberculosis mimicking carcinoma gall bladder. (15778524)
2005
23
Hepatic tuberculosis presenting as cholestatic jaundice. A case report. (16737053)
2005
24
Imaging diagnosis of 12 patients with hepatic tuberculosis. (15162540)
2004
25
Isolated hepatic tuberculosis in a transplanted liver. (15522111)
2004
26
The nodular form of hepatic tuberculosis: a review with five additional new cases. (14600128)
2003
27
Localized hepatic tuberculosis. (14962708)
2003
28
Clinical spectrum of hepatic tuberculosis: comparison between immunocompetent and immunocompromised hosts. (12930021)
2003
29
Hepatic tuberculosis--a case report. (12797646)
2002
30
Computed tomography and angiography in hepatic tuberculosis mimicking liver tumor. (11573902)
2001
31
Miliary hepatic tuberculosis not associated with splenic or lung involvement. A case report. (11016770)
2000
32
Isolated hepatic tuberculosis: report of five cases and review of the literature. (10398910)
1999
33
Hepatic tuberculosis: comparison of miliary and local form. (7744492)
1995
34
Nodular form of local hepatic tuberculosis: case report. (7714939)
1995
35
The "cluster" sign in macronodular hepatic tuberculosis: CT features. (8419431)
1993
36
Primary hepatic tuberculosis in homozygous alpha-1-antitrypsin deficiency. (1562749)
1992
37
The nodular form of local hepatic tuberculosis. A review. (2157746)
1990
38
Macronodular hepatic tuberculosis in a child: computed tomographic appearances. (2400887)
1990
39
Primary macronodular hepatic tuberculosis: US and CT appearances. (2210202)
1990
40
Hepatic tuberculosis; a rare case of bleeding gastric varices. (2238132)
1990
41
Isolated hepatic tuberculosis with scrofuloderma. (3671278)
1987
42
A prospective study of hepatic tuberculosis in 41 black patients. (3659266)
1987
43
Local hepatic tuberculosis, the cause of a painful hepatic mass: case report and review of the literature. (3096551)
1986
44
Simultaneous hepatic tuberculosis, cirrhosis and hepatoma. A case report. (6320473)
1983
45
Hepatic tuberculosis simulating hepatic amoebiasis. (6671942)
1983
46
Spleno-hepatic tuberculosis due to Mycobacterium kansasii. (979821)
1976
47
Hepatic tuberculosis with haemosiderosis. (1052798)
1976
48
An unusual case of hemobilia. Hepatic tuberculosis with hemorrhage. (16097285)
1967
49
CLINICALLY ISOLATED HEPATIC TUBERCULOSIS]. (14149344)
1964
50
Hepatic tuberculosis in a patient with sickle-cell anemia who died of fatal post-transfusion hepatitis. (13031044)
1953

Variations for Hepatic Tuberculosis

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Expression for genes affiliated with Hepatic Tuberculosis

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hepatic Tuberculosis

Search GEO for disease gene expression data for Hepatic Tuberculosis.

Pathways for genes affiliated with Hepatic Tuberculosis

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Sources:
50PathCards, 30KEGG, 38NCBI BioSystems Database, 55Reactome, 12EMD Millipore
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Pathways related to Hepatic Tuberculosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Complement Activation, Classical Pathway38
Complement and Coagulation Cascades38
9.5F2, SERPINA1
2
Show member pathways
9.4SERPINA1, ALB
39.4SERPINA1, ALB
49.3ALB, F2
5
Show member pathways
8.9ALB, F2, SERPINA1
6
Show member pathways
thioredoxin pathway38
8.8F2, ALB, GGT1

Compounds for genes affiliated with Hepatic Tuberculosis

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Sources:
45Novoseek, 11DrugBank, 51PharmGKB, 29IUPHAR, 24HMDB, 3BitterDB, 61Tocris Bioscience
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Compounds related to Hepatic Tuberculosis according to GeneCards/GeneDecks:

(show top 50)    (show all 80)
idCompoundScoreTop Affiliating Genes
1aminopyrine459.8GGT1, F2
2cefotetan45 1110.8F2, ALB
3dextran 70459.7F2, ALB
4terlipressin45 1110.7ALB, F2
5hepaplastin459.7ALB, F2
6cefoperazone45 1110.7F2, ALB
7oxcarbazepine45 51 1111.7GGT1, ALB
8gamma globulin459.7GGT1, ALB
9acenocoumarol45 51 1111.7ALB, F2
10phenprocoumon45 51 1111.7F2, ALB
11hydroxyethyl starch459.7ALB, F2
12amiodarone45 51 29 1112.7F2, GGT1
13ethacrynic acid45 1110.6ALB, GGT1
14diisopropylfluorophosphate459.6ALB, SERPINA1
15l-tryptophan51 29 45 24 1113.6GGT1, ALB
16alpha lipoic acid459.5SERPINA1, GGT1
17propylthiouracil45 3 1111.4GGT1, ALPP
18diflunisal45 1110.4ALB, ALPP
19phenylbutazone45 1110.3F2, SERPINA1, ALB
20antipyrine45 1110.3GGT1, F2, ALB
21cellulose acetate459.2ALB, ALPP
22vitamin a45 24 1111.2GGT1, ALB, SERPINA1
23hyaluronic acid45 2410.2F2, ALB, GGT1
24vitamin b6459.1ALPP, ALB
25silymarin459.1GGT1, F2
26fibrinogen459.1SERPINA1, F2, ALB
27methotrexate51 45 1111.1F2, ALB, GGT1
28ursodeoxycholic acid45 24 1111.0F2, ALPP, GGT1
2925-hydroxyvitamin d459.0ALPP, ALB
30bezafibrate45 29 1111.0ALPP, GGT1
31iron45 2410.0GGT1, SERPINA1, ALB
32sevoflurane51 45 1111.0ALPP, ALB, GGT1
33isoflurane51 45 1110.9ALPP, ALB, GGT1
34phosphorus458.9GGT1, ALPP, ALB
35pyridoxal 5-phosphate458.9GGT1, ALPP, ALB
36phenytoin45 51 29 1111.9ALB, ALPP, GGT1
37vitamin b12458.9ALPP, ALB, GGT1
38polyethylene glycol458.9F2, ALPP, ALB
39thyroxine45 249.9GGT1, ALB, ALPP
40tamoxifen45 51 29 1111.9ALPP, F2, GGT1
41calcitriol45 61 24 1111.9ALB, F2, ALPP
42ascorbic acid45 249.5SERPINA1, ALB, ALPP, GGT1
43cholesterol45 29 24 1111.5GGT1, SERPINA1, ALB, ALPP
44lactate458.4GGT1, ALPP, F2, ALB
45aspartate458.4GGT1, F2, ALPP, ALB
46alanine458.4ALB, ALPP, F2, GGT1
47cysteine458.4ALB, GGT1, ALPP, SERPINA1
48serine458.2ALPP, GGT1, SERPINA1, F2
49creatinine458.0GGT1, ALPP, F2, SERPINA1, ALB
50heparin45 29 24 1111.0GGT1, ALB, ALPP, SERPINA1, F2

GO Terms for genes affiliated with Hepatic Tuberculosis

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16Gene Ontology
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Cellular components related to Hepatic Tuberculosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.3ALB, SERPINA1
2blood microparticleGO:0725629.0ALB, F2
3extracellular spaceGO:0056158.9ALB, SERPINA1, F2

Biological processes related to Hepatic Tuberculosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1acute-phase responseGO:0069539.4SERPINA1, F2
2platelet degranulationGO:0025769.4SERPINA1, ALB
3platelet activationGO:0301688.9F2, SERPINA1, ALB
4blood coagulationGO:0075968.6F2, SERPINA1, ALB

Products for genes affiliated with Hepatic Tuberculosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hepatic Tuberculosis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet