MCID: HPT008
MIFTS: 45

Hepatic Tuberculosis malady

Liver diseases category

Summaries for Hepatic Tuberculosis

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8Disease Ontology, 32MalaCards
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Disease Ontology:8 A gastrointestinal tuberculosis that involves infection located in liver, which results in the formation of tuberculous granulomas. the infection has symptom fever, has symptom anorexia, has symptom weight loss, has symptom abdominal pain and has symptom jaundice.

MalaCards: Hepatic Tuberculosis, also known as tuberculosis of liver, is related to tuberculosis and hepatitis, and has symptoms including jaundice, abdominal pain and weight loss. An important gene associated with Hepatic Tuberculosis is SERPINA1 (serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1), and among its related pathways are Complement and coagulation cascades and Platelet degranulation . The compounds heparin and vitamin a have been mentioned in the context of this disorder. Affiliated tissues include liver, liver and lymph node.

Aliases & Classifications for Hepatic Tuberculosis

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Sources:
8Disease Ontology, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Liver diseases


Aliases & Descriptions:

hepatic tuberculosis 8
tuberculosis of liver 8
tuberculosis, hepatic 60
tuberculosis hepatic 44


External Ids:

Disease Ontology8 DOID:407
SNOMED-CT56 186273003
MeSH34 D014386

Related Diseases for Hepatic Tuberculosis

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Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Hepatic Tuberculosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 122)
idRelated DiseaseScoreTop Affiliating Genes
1tuberculosis31.2SERPINA1, ALB
2hepatitis31.2F2, SERPINA1, ALPP, GGT1
3hepatitis a30.9F2
4acquired immunodeficiency syndrome29.9ALB
5portal vein thrombosis29.9F2
6colorectal cancer29.9SERPINA1, ALPP
7obstructive jaundice29.9GGT1, ALPP
8adenocarcinoma29.9GGT1, SERPINA1
9portal hypertension29.9ALB, GGT1, F2
10hypertension29.9GGT1, F2, ALB
11miliary tuberculosis10.1
12renal tuberculosis10.0
13hyperthyroidism10.0ALPP
14hypophosphatemia10.0ALPP
15acute pancreatitis10.0SERPINA1
16inflammatory bowel disease10.0ALPP
17periodontal disease10.0ALPP
18crohn's disease10.0ALB
19rheumatoid arthritis10.0SERPINA1
20malaria10.0ALB
21metabolic acidosis10.0ALB
22respiratory failure10.0SERPINA1
23hemochromatosis10.0SERPINA1
24ulcerative colitis10.0ALB
25hyperphosphatemia10.0ALPP
26stomach cancer10.0SERPINA1
27melanoma10.0SERPINA1
28choriocarcinoma10.0ALPP
29lung cancer10.0ALB
30biliary atresia10.0GGT1
31gallbladder disease10.0GGT1
32hypercholesterolemia10.0GGT1
33protein-energy malnutrition10.0ALB
34oral cancer10.0GGT1
35vascular disease10.0ALPP
36coronary heart disease10.0GGT1
37gingivitis10.0ALPP
38short bowel syndrome10.0ALB
39acute myocardial infarction10.0SERPINA1
40osteogenesis imperfecta10.0ALPP
41pulmonary disease, chronic obstructive10.0SERPINA1
42peripheral vascular disease10.0ALB
43pulmonary eosinophilia10.0GGT1
44adenoma10.0GGT1
45ovarian hyperstimulation syndrome10.0ALB
46obesity10.0GGT1
47alpha 1-antitrypsin deficiency10.0SERPINA1
48rickets10.0ALPP
49hypersplenism10.0F2
50dysfibrinogenemia10.0F2

Graphical network of the top 20 diseases related to Hepatic Tuberculosis:



Diseases related to hepatic tuberculosis

Clinical Features for Hepatic Tuberculosis

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Sources:
8Disease Ontology
See all sources


Symptoms:

8
  • jaundice
  • abdominal pain
  • weight loss
  • anorexia
  • fever

Drugs & Therapeutics for Hepatic Tuberculosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Hepatic Tuberculosis

Drug clinical trials:

Search ClinicalTrials for Hepatic Tuberculosis

Search NIH Clinical Center for Hepatic Tuberculosis

Search CenterWatch for Hepatic Tuberculosis

Genetic Tests for Hepatic Tuberculosis

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Anatomical Context for Hepatic Tuberculosis

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Sources:
32MalaCards, 14FMA
See all sources

MalaCards organs/tissues related to Hepatic Tuberculosis:

32
Liver, Lymph node, Monocytes, Lung

FMA organs/tissues related to Hepatic Tuberculosis:

14
Liver

Animal Models for Hepatic Tuberculosis or affiliated genes

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Publications for Hepatic Tuberculosis

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Sources:
50PubMed
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Articles related to Hepatic Tuberculosis:

(show top 50)    (show all 112)
idTitleAuthorsYear
1
Program Collaboration and Service Integration in the Prevention and Control of HIV Infection, Viral Hepatitis, STDs, and Tuberculosis in the U.S.: Lessons Learned from the Field. (24385642)
2014
2
Cytochrome P450 2E1 gene polymorphisms/haplotypes and anti-tuberculosis drug-induced hepatitis in a Chinese cohort. (23460870)
2013
3
Primary isolated hepatic tuberculosis. (23673179)
2013
4
Atypical presentation of miliary tuberculosis with hepatic involvement early after renal transplantation. (23142602)
2013
5
Dengue fever, tuberculosis, human immunodeficiency virus, and hepatitis C virus conversion in a group of long-term development aid workers. (24118595)
2013
6
Enhancing HIV/AIDS, viral hepatitis, sexually transmitted disease, and tuberculosis prevention in the United States through program collaboration and service integration: the case for broader implementation. (23859918)
2013
7
Esophageal tuberculosis during treatment of hepatitis C. (23639604)
2013
8
Matching HIV, Tuberculosis, Viral Hepatitis, and Sexually Transmitted Diseases Surveillance Data, 2000-2010: Identification of Infectious Disease Syndemics in New York City. (24335712)
2013
9
Hepatic tuberculosis presenting with extreme hyperferritinemia masquerading as adult-onset Still's disease: a case report. (22788693)
2012
10
Hepatic tuberculosis in a patient treated with infliximab. (21793022)
2011
11
Relationship between the polymorphisms of UGT1A6 genes and anti-tuberculosis drug induced hepatic-injury]. (21586239)
2011
12
Pseudo-tumoral hepatic tuberculosis: a report of two cases. (20306917)
2010
13
Pseudotumoral hepatic tuberculosis with pericardial abscess. (21045410)
2010
14
Hepatitis associated with prothionamide for treatment of multidrug-resistant tuberculosis. (21195892)
2010
15
Primary nodular hepatic tuberculosis mimicking hepatic neoplasia in an immunocompetent host. (20140362)
2009
16
Pandemic influenza: implications for programs controlling for HIV infection, tuberculosis, and chronic viral hepatitis. (19797745)
2009
17
Primary hepatic tuberculosis in an immunocompetent patient: the Great Mimic. (19795040)
2009
18
Evaluation of hepatic function in new cases of pulmonary tuberculosis due to the use of standard chemotherapy regimens I and IIB]. (19382645)
2009
19
Granulomatous hepatitis: tuberculosis or not? (18241177)
2008
20
CT appearance of primary localized nodular hepatic tuberculosis in an immunocompetent patient. (18541946)
2008
21
Isolated hepatic tuberculosis presenting as cystic-like and tumour-like mass lesions. (21490832)
2008
22
Prevalence and risk factors of anti-tuberculosis drug-induced hepatitis in Malaysia. (18830542)
2008
23
Case report of lymph nodal, hepatic and splenic tuberculosis in an HIV-positive patient. (16878268)
2006
24
Is liver transplantation advisable for isoniazid fulminant hepatitis in active extrapulmonary tuberculosis? (16212643)
2005
25
Macronodular hepatic tuberculosis associated with portal vein thrombosis and portal hypertension. (16026440)
2005
26
Isolated hepatic tuberculosis in a transplanted liver. (15522111)
2004
27
Secular increase in the incidence rate of drug-induced hepatitis due to anti-tuberculosis chemotherapy including isoniazid and rifampicin]. (12739393)
2003
28
Localized hepatic tuberculosis. (14962708)
2003
29
Computed tomography and angiography in hepatic tuberculosis mimicking liver tumor. (11573902)
2001
30
Hepatic enzyme abnormalities in children on triple therapy for tuberculosis. (10023790)
1999
31
Isolated hepatic tuberculosis: report of five cases and review of the literature. (10398910)
1999
32
Mannose binding protein deficiency is not associated with malaria, hepatitis B carriage nor tuberculosis in Africans. (9519208)
1998
33
Abdominal tuberculosis involving hepatic hilar lymph nodes. (9600377)
1998
34
Abdominal tuberculosis involving hepatic hilar lymph nodes. A cause of portal vein thrombosis and portal hypertension. (9412974)
1997
35
The "cluster" sign in macronodular hepatic tuberculosis: CT features. (8419431)
1993
36
CD30 expression by peripheral blood monocytes and hepatic macrophages in a child with miliary tuberculosis. (1325482)
1992
37
Combined chemotherapy of toxic hepatitis in patients with pulmonary tuberculosis]. (1409510)
1992
38
Primary hepatic tuberculosis in homozygous alpha-1-antitrypsin deficiency. (1562749)
1992
39
Focal hepatic tuberculosis in a patient with acquired immunodeficiency syndrome. (2000536)
1991
40
Macronodular hepatic tuberculosis in a child: computed tomographic appearances. (2400887)
1990
41
Primary macronodular hepatic tuberculosis: US and CT appearances. (2210202)
1990
42
Hepatic tuberculosis; a rare case of bleeding gastric varices. (2238132)
1990
43
Atypical hepatic tuberculosis presenting as obstructive jaundice. (3421231)
1988
44
A prospective study of hepatic tuberculosis in 41 black patients. (3659266)
1987
45
Hepatic tuberculosis simulating hepatic amoebiasis. (6671942)
1983
46
Spleno-hepatic tuberculosis due to Mycobacterium kansasii. (979821)
1976
47
The differential diagnostic problems of tuberculosis and sarcoidosis in granulomatous hepatitis. (4128228)
1973
48
CLINICALLY ISOLATED HEPATIC TUBERCULOSIS]. (14149344)
1964
49
Hepatic involvement in extrapulmonary tuberculosis; histologic and functional characteristics. (13661188)
1959
50
Chronic granulomatous hepatitis, suggestive of tuberculosis. (18858909)
1948

Genetic Variations for Hepatic Tuberculosis

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Expression for genes affiliated with Hepatic Tuberculosis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Hepatic Tuberculosis

Search GEO for disease gene expression data for Hepatic Tuberculosis.

Pathways for genes affiliated with Hepatic Tuberculosis

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Sources:
29KEGG, 37NCBI BioSystems Database, 53Reactome, 12EMD Millipore
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Pathways related to Hepatic Tuberculosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.5SERPINA1, F2
2
Hide members
9.4ALB, SERPINA1
39.4SERPINA1, ALB
49.3ALB, F2
5
Hide members
8.9ALB, SERPINA1, F2
68.8ALB, GGT1, F2

Compounds for genes affiliated with Hepatic Tuberculosis

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Hepatic Tuberculosis according to GeneCards/GeneDecks:

(show top 50)    (show all 59)
idCompoundScoreTop Affiliating Genes
1heparin44 28 11 2413.5SERPINA1
2vitamin a44 11 2412.3SERPINA1
3diisopropylfluorophosphate4410.3SERPINA1
4aminopyrine449.8F2, GGT1
5cefotetan44 1110.8ALB, F2
6dextran 70449.7ALB, F2
7terlipressin44 1110.7F2, ALB
8hepaplastin449.7F2, ALB
9oxcarbazepine44 1110.7ALB, GGT1
10cefoperazone44 1110.7ALB, F2
11gamma globulin449.7ALB, GGT1
12acenocoumarol44 49 1111.7F2, ALB
13amiodarone44 49 28 1112.7GGT1, F2
14phenprocoumon44 49 1111.7ALB, F2
15hydroxyethyl starch449.7F2, ALB
16l-tryptophan44 28 11 2412.6ALB, GGT1
17alpha lipoic acid449.6SERPINA1, GGT1
18silymarin449.4GGT1, F2
19diflunisal44 1110.4ALPP, ALB
20serine449.4ALPP
21phenylbutazone44 1110.3SERPINA1, F2, ALB
22bezafibrate44 28 1111.3GGT1, ALPP
23antipyrine44 1110.3ALB, GGT1, F2
24cellulose acetate449.3ALB, ALPP
25vitamin b6449.2ALPP, ALB
26mycophenolate mofetil44 49 1111.2ALB, GGT1
2725-hydroxyvitamin d449.2ALB, ALPP
28hyaluronic acid44 2410.2F2, GGT1, ALB
29fibrinogen449.1ALB, F2, SERPINA1
30carbamazepine44 49 1111.1ALPP, GGT1
31methotrexate44 49 1111.1GGT1, F2, ALB
32ursodeoxycholic acid44 11 2411.0ALPP, GGT1, F2
33iron44 2410.0SERPINA1, GGT1, ALB
34sevoflurane44 1110.0GGT1, ALPP, ALB
35isoflurane44 119.9GGT1, ALB, ALPP
36phosphorus448.9ALPP, ALB, GGT1
37pyridoxal 5-phosphate448.9ALB, GGT1, ALPP
38phenytoin44 49 28 1111.9ALB, ALPP, GGT1
39vitamin b12448.9GGT1, ALPP, ALB
40polyethylene glycol448.9ALPP, F2, ALB
41tamoxifen44 49 28 1111.9F2, GGT1, ALPP
42thyroxine44 249.9ALB, ALPP, GGT1
43calcitriol44 59 11 2411.8ALPP, ALB, F2
44ascorbic acid44 249.5SERPINA1, GGT1, ALB, ALPP
45cholesterol44 28 11 2411.4SERPINA1, ALB, GGT1, ALPP
46lactate448.4F2, GGT1, ALPP, ALB
47aspartate448.4ALPP, F2, GGT1, ALB
48cysteine448.4ALB, GGT1, SERPINA1, ALPP
49alanine448.3F2, ALPP, GGT1, ALB
50creatinine448.0GGT1, SERPINA1, ALPP, ALB, F2

GO Terms for genes affiliated with Hepatic Tuberculosis

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16Gene Ontology
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Cellular components related to Hepatic Tuberculosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.4ALB, SERPINA1

Biological processes related to Hepatic Tuberculosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1acute-phase responseGO:0069539.4SERPINA1, F2
2platelet degranulationGO:0025769.4ALB, SERPINA1
3platelet activationGO:0301688.9ALB, SERPINA1, F2
4blood coagulationGO:0075968.6F2, SERPINA1, ALB

Products for genes affiliated with Hepatic Tuberculosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hepatic Tuberculosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet