MCID: HPT008
MIFTS: 45

Hepatic Tuberculosis malady

Liver diseases category

Summaries for Hepatic Tuberculosis

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8Disease Ontology, 32MalaCards
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Disease Ontology:8 A gastrointestinal tuberculosis that involves infection located in liver, which results in the formation of tuberculous granulomas. the infection has symptom fever, has symptom anorexia, has symptom weight loss, has symptom abdominal pain and has symptom jaundice.

MalaCards: Hepatic Tuberculosis, also known as tuberculosis of liver, is related to tuberculosis and hepatitis, and has symptoms including jaundice, abdominal pain and weight loss. An important gene associated with Hepatic Tuberculosis is SERPINA1 (serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1), and among its related pathways are Complement and coagulation cascades and Platelet degranulation . The compounds heparin and vitamin a have been mentioned in the context of this disorder. Affiliated tissues include liver, liver and lymph node.

Aliases & Classifications for Hepatic Tuberculosis

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Sources:
8Disease Ontology, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Liver diseases


Aliases & Descriptions:

hepatic tuberculosis 8
tuberculosis of liver 8
tuberculosis, hepatic 60
tuberculosis hepatic 44


External Ids:

Disease Ontology8 DOID:407
SNOMED-CT56 186273003
MeSH34 D014386

Related Diseases for Hepatic Tuberculosis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Hepatic Tuberculosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 122)
idRelated DiseaseScoreTop Affiliating Genes
1tuberculosis31.2SERPINA1, ALB
2hepatitis31.2F2, SERPINA1, ALPP, GGT1
3hepatitis a30.9F2
4acquired immunodeficiency syndrome29.9ALB
5portal vein thrombosis29.9F2
6colorectal cancer29.9SERPINA1, ALPP
7obstructive jaundice29.9GGT1, ALPP
8adenocarcinoma29.9GGT1, SERPINA1
9portal hypertension29.9ALB, GGT1, F2
10hypertension29.9GGT1, F2, ALB
11miliary tuberculosis10.1
12renal tuberculosis10.0
13hyperthyroidism10.0ALPP
14hypophosphatemia10.0ALPP
15acute pancreatitis10.0SERPINA1
16inflammatory bowel disease10.0ALPP
17periodontal disease10.0ALPP
18crohn's disease10.0ALB
19rheumatoid arthritis10.0SERPINA1
20malaria10.0ALB
21metabolic acidosis10.0ALB
22respiratory failure10.0SERPINA1
23hemochromatosis10.0SERPINA1
24ulcerative colitis10.0ALB
25hyperphosphatemia10.0ALPP
26stomach cancer10.0SERPINA1
27melanoma10.0SERPINA1
28choriocarcinoma10.0ALPP
29lung cancer10.0ALB
30biliary atresia10.0GGT1
31gallbladder disease10.0GGT1
32hypercholesterolemia10.0GGT1
33protein-energy malnutrition10.0ALB
34oral cancer10.0GGT1
35vascular disease10.0ALPP
36coronary heart disease10.0GGT1
37gingivitis10.0ALPP
38short bowel syndrome10.0ALB
39acute myocardial infarction10.0SERPINA1
40osteogenesis imperfecta10.0ALPP
41pulmonary disease, chronic obstructive10.0SERPINA1
42peripheral vascular disease10.0ALB
43pulmonary eosinophilia10.0GGT1
44adenoma10.0GGT1
45ovarian hyperstimulation syndrome10.0ALB
46obesity10.0GGT1
47alpha 1-antitrypsin deficiency10.0SERPINA1
48rickets10.0ALPP
49hypersplenism10.0F2
50dysfibrinogenemia10.0F2

Graphical network of the top 20 diseases related to Hepatic Tuberculosis:



Diseases related to hepatic tuberculosis

Clinical Features for Hepatic Tuberculosis

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Sources:
8Disease Ontology
See all sources


Symptoms:

8
  • jaundice
  • abdominal pain
  • weight loss
  • anorexia
  • fever

Drugs & Therapeutics for Hepatic Tuberculosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Hepatic Tuberculosis

Drug clinical trials:

Search ClinicalTrials for Hepatic Tuberculosis

Search NIH Clinical Center for Hepatic Tuberculosis

Search CenterWatch for Hepatic Tuberculosis

Genetic Tests for Hepatic Tuberculosis

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Anatomical Context for Hepatic Tuberculosis

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Hepatic Tuberculosis:

32
Liver, Lymph node, Monocytes, Lung

FMA organs/tissues related to Hepatic Tuberculosis:

14
Liver

Animal Models for Hepatic Tuberculosis or affiliated genes

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Publications for Hepatic Tuberculosis

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Sources:
50PubMed
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Articles related to Hepatic Tuberculosis:

(show top 50)    (show all 112)
idTitleAuthorsYear
1
Probable hepatic tuberculosis masquerading as Klatskin tumour in an immunocompetent patient. (24343799)
2013
2
The liver Metastatic Adenocarcinoma of Colorectal Cancer With Synchronous Isolated Hepatic Tuberculosis. (23967026)
2013
3
Hepatic Tuberculosis Mimics Metastasis Revealed by 18F-FDG PET/CT. (24152632)
2013
4
Anti-tuberculosis drug-induced hepatitis in renal transplant patient with pulmonary and extra pulmonary tuberculosis. (23960791)
2012
5
Primary hepatic tuberculosis: a rare but fatal clinical entity if undiagnosed. (22575985)
2012
6
Integrated prevention services for HIV infection, viral hepatitis, sexually transmitted diseases, and tuberculosis for persons who use drugs illicitly: summary guidance from CDC and the U.S. Department of Health and Human Services. (23135062)
2012
7
Hepatic tuberculosis presenting with extreme hyperferritinemia masquerading as adult-onset Still's disease: a case report. (22788693)
2012
8
Hepatic tuberculosis in a patient treated with infliximab. (21793022)
2011
9
NAT2 and CYP2E1 polymorphisms and susceptibility to first-line anti-tuberculosis drug-induced hepatitis. (20392357)
2010
10
Corticosteroids in the treatment of hepatic tuberculosis: case report and review of the literature. (20092380)
2010
11
Addressing social determinants of health in the prevention and control of HIV/AIDS, viral hepatitis, sexually transmitted infections, and tuberculosis. (20629250)
2010
12
Peritoneal tuberculosis and granulomatous hepatitis secondary to treatment of bladder cancer with Bacillus Calmette-GuAcrin. (19368735)
2009
13
Frequency and predictive factors of granulomatous hepatitis in patients with peritoneal tuberculosis. (19927783)
2009
14
Isolated hepatic tuberculosis. (20071827)
2008
15
Hepatic tuberculosis mimicking Klatskin tumor: a diagnostic dilemma. (18723964)
2008
16
Macronodular hepatic tuberculosis necessitating hepatic resection: a diagnostic conundrum. (18031627)
2007
17
Interferon-alpha treatment of hepatitis D induces tuberculosis exacerbation in an immigrant. (17307255)
2007
18
Clinical study of deoxyribonucleotidum for adjuvant treatment of pulmonary tuberculosis with hepatic lesion]. (16864110)
2006
19
Localized hepatic tuberculosis presenting as fever of unknown origin. (17293928)
2006
20
Renal tuberculosis simulating xanthogranulomatous pyelonephritis with contagious hepatic involvement. (16448435)
2006
21
Hepatic tuberculosis in absence of disseminated abdominal tuberculosis. (16531964)
2006
22
Hepatic tuberculosis mimicking carcinoma gall bladder. (15778524)
2005
23
Imaging diagnosis of 12 patients with hepatic tuberculosis. (15162540)
2004
24
The nodular form of hepatic tuberculosis: a review with five additional new cases. (14600128)
2003
25
Clinical spectrum of hepatic tuberculosis: comparison between immunocompetent and immunocompromised hosts. (12930021)
2003
26
Pseudotumoral hepatic tuberculosis. (12971980)
2003
27
Hepatic tuberculosis--a case report. (12797646)
2002
28
Hepatosplenic schistosomiasis presenting as granulomatous hepatitis in an immigrant from the Philippines with pulmonary tuberculosis, tuberculous lymphadenitis, and a history of alcohol abuse. (11712505)
2001
29
Hepatic artery pseudoaneurysms in a patient treated for miliary tuberculosis. (11065259)
2000
30
Miliary hepatic tuberculosis not associated with splenic or lung involvement. A case report. (11016770)
2000
31
Abdominal tuberculosis involving hepatic hilar lymph nodes. (9600377)
1998
32
Fatal hepatic failure caused by miliary tuberculosis in a hemodialysis patient: case report. (9554822)
1998
33
Recurrent Salmonella enteritidis sepsis and hepatic tuberculosis. (7672664)
1995
34
CD30 expression by peripheral blood monocytes and hepatic macrophages in a child with miliary tuberculosis. (1325482)
1992
35
Miliary tuberculosis presenting as fever and jaundice with hepatic failure. (1985084)
1991
36
Miliary tuberculosis presenting as hepatic and renal failure. (1995237)
1991
37
The nodular form of local hepatic tuberculosis. A review. (2157746)
1990
38
Primary macronodular hepatic tuberculosis: US and CT appearances. (2210202)
1990
39
Budd Chiari syndrome in a child with hepatic tuberculosis. (2807366)
1989
40
Isolated hepatic tuberculosis with scrofuloderma. (3671278)
1987
41
A prospective study of hepatic tuberculosis in 41 black patients. (3659266)
1987
42
Granulocytopenia, jaundice and hepatic coma with disseminated tuberculosis. (3793681)
1986
43
Local hepatic tuberculosis, the cause of a painful hepatic mass: case report and review of the literature. (3096551)
1986
44
Spleno-hepatic tuberculosis due to Mycobacterium kansasii. (979821)
1976
45
Hepatic tuberculosis with haemosiderosis. (1052798)
1976
46
Hepatic involvement in abdominal tuberculosis (a clinical, biochemical and histopathological study). (4654916)
1972
47
Granulomatous hepatitis in the diagnosis of tuberculosis. A clinico-pathological study of 15 cases. (5097553)
1971
48
An unusual case of hemobilia. Hepatic tuberculosis with hemorrhage. (16097285)
1967
49
DIAGNOSTIC PROBLEMS IN HEPATIC TUBERCULOSIS. (14225675)
1964
50
Chronic granulomatous hepatitis, suggestive of tuberculosis. (18858909)
1948

Genetic Variations for Hepatic Tuberculosis

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Expression for genes affiliated with Hepatic Tuberculosis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Hepatic Tuberculosis

Search GEO for disease gene expression data for Hepatic Tuberculosis.

Pathways for genes affiliated with Hepatic Tuberculosis

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Sources:
29KEGG, 37NCBI BioSystems Database, 53Reactome, 12EMD Millipore
See all sources

Pathways related to Hepatic Tuberculosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.5SERPINA1, F2
2
Hide members
9.4ALB, SERPINA1
39.4ALB, SERPINA1
49.3ALB, F2
5
Hide members
8.9ALB, SERPINA1, F2
68.8ALB, GGT1, F2

Compounds for genes affiliated with Hepatic Tuberculosis

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience
See all sources

Compounds related to Hepatic Tuberculosis according to GeneCards/GeneDecks:

(show top 50)    (show all 59)
idCompoundScoreTop Affiliating Genes
1heparin44 28 11 2413.5SERPINA1
2vitamin a44 11 2412.3SERPINA1
3diisopropylfluorophosphate4410.3SERPINA1
4aminopyrine449.8F2, GGT1
5cefotetan44 1110.8ALB, F2
6dextran 70449.7ALB, F2
7terlipressin44 1110.7F2, ALB
8hepaplastin449.7F2, ALB
9oxcarbazepine44 1110.7ALB, GGT1
10cefoperazone44 1110.7ALB, F2
11gamma globulin449.7ALB, GGT1
12acenocoumarol44 49 1111.7F2, ALB
13amiodarone44 49 28 1112.7GGT1, F2
14phenprocoumon44 49 1111.7ALB, F2
15hydroxyethyl starch449.7F2, ALB
16l-tryptophan44 28 11 2412.6ALB, GGT1
17alpha lipoic acid449.6SERPINA1, GGT1
18silymarin449.4GGT1, F2
19diflunisal44 1110.4ALPP, ALB
20serine449.4ALPP
21phenylbutazone44 1110.3SERPINA1, F2, ALB
22bezafibrate44 28 1111.3GGT1, ALPP
23antipyrine44 1110.3ALB, GGT1, F2
24cellulose acetate449.3ALB, ALPP
25vitamin b6449.2ALPP, ALB
26mycophenolate mofetil44 49 1111.2ALB, GGT1
2725-hydroxyvitamin d449.2ALB, ALPP
28hyaluronic acid44 2410.2F2, GGT1, ALB
29fibrinogen449.1ALB, F2, SERPINA1
30carbamazepine44 49 1111.1ALPP, GGT1
31methotrexate44 49 1111.1GGT1, F2, ALB
32ursodeoxycholic acid44 11 2411.0ALPP, GGT1, F2
33iron44 2410.0SERPINA1, GGT1, ALB
34sevoflurane44 1110.0GGT1, ALPP, ALB
35isoflurane44 119.9GGT1, ALB, ALPP
36phosphorus448.9ALPP, ALB, GGT1
37pyridoxal 5-phosphate448.9ALB, GGT1, ALPP
38phenytoin44 49 28 1111.9ALB, ALPP, GGT1
39vitamin b12448.9GGT1, ALPP, ALB
40polyethylene glycol448.9ALPP, F2, ALB
41tamoxifen44 49 28 1111.9F2, GGT1, ALPP
42thyroxine44 249.9ALB, ALPP, GGT1
43calcitriol44 59 11 2411.8ALPP, ALB, F2
44ascorbic acid44 249.5SERPINA1, GGT1, ALB, ALPP
45cholesterol44 28 11 2411.4SERPINA1, ALB, GGT1, ALPP
46lactate448.4F2, GGT1, ALPP, ALB
47aspartate448.4ALPP, F2, GGT1, ALB
48cysteine448.4ALB, GGT1, SERPINA1, ALPP
49alanine448.3F2, ALPP, GGT1, ALB
50creatinine448.0GGT1, SERPINA1, ALPP, ALB, F2

GO Terms for genes affiliated with Hepatic Tuberculosis

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Sources:
16Gene Ontology
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Cellular components related to Hepatic Tuberculosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.4ALB, SERPINA1

Biological processes related to Hepatic Tuberculosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1acute-phase responseGO:0069539.4SERPINA1, F2
2platelet degranulationGO:0025769.4SERPINA1, ALB
3platelet activationGO:0301688.9F2, SERPINA1, ALB
4blood coagulationGO:0075968.6F2, SERPINA1, ALB

Products for genes affiliated with Hepatic Tuberculosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hepatic Tuberculosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet