MCID: HPT008
MIFTS: 37

Hepatic Tuberculosis

Categories: Skin diseases, Infectious diseases, Liver diseases

Aliases & Classifications for Hepatic Tuberculosis

MalaCards integrated aliases for Hepatic Tuberculosis:

Name: Hepatic Tuberculosis 12 14
Tuberculosis, Hepatic 42 69
Tuberculosis of Liver 12
Tuberculosis Hepatic 52

Classifications:



External Ids:

Disease Ontology 12 DOID:407
MeSH 42 D014386
SNOMED-CT 64 186273003
UMLS 69 C0041313

Summaries for Hepatic Tuberculosis

Disease Ontology : 12 A gastrointestinal tuberculosis that involves infection located in liver, which results in the formation of tuberculous granulomas. The infection has symptom fever, has symptom anorexia, has symptom weight loss, has symptom abdominal pain and has symptom jaundice.

MalaCards based summary : Hepatic Tuberculosis, also known as tuberculosis, hepatic, is related to obstructive jaundice and hepatocellular carcinoma. An important gene associated with Hepatic Tuberculosis is ALPP (Alkaline Phosphatase, Placental), and among its related pathways/superpathways are NRF2 pathway and Busulfan Pathway, Pharmacodynamics. The drugs Rifampin and Estradiol have been mentioned in the context of this disorder. Affiliated tissues include liver, skin and lung.

Related Diseases for Hepatic Tuberculosis

Diseases related to Hepatic Tuberculosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 118)
id Related Disease Score Top Affiliating Genes
1 obstructive jaundice 29.3 ALB F2
2 hepatocellular carcinoma 27.5 ALB F2 GGT1 GPT SERPINA1
3 non-hodgkin lymphoma, during pregnancy 10.6 ALB F2
4 fragile x syndrome type 2 10.5 ALB F2
5 duane retraction syndrome 10.5 ALB F2
6 neurogenic thoracic outlet syndrome 10.5 ALPP GPT
7 chronic inflammatory demyelinating polyneuritis 10.5 ALB F2
8 angelucci's syndrome 10.5 ALB F2
9 atrophic vulva 10.5 ALB F2
10 argyria 10.5 F2 GPT
11 childhood brain stem glioma 10.5 ALB F2
12 rete ovarii adenoma 10.5 ALB F2
13 myopia 10.5 ALB F2
14 maxillary sinusitis 10.5 F2 GPT
15 capillary hemangioma 10.4 ALB F2
16 dyskeratosis congenita autosomal recessive 10.4 ALB F2
17 aryepiglottic fold cancer 10.4 ALB F2
18 hepatitis 10.4
19 tuberculosis 10.4
20 ischemic heart disease 10.4 ALB F2
21 mediastinum leiomyoma 10.4 ALB F2
22 dentinogenesis imperfecta 10.4 ALB F2
23 bronchiolo-alveolar adenocarcinoma 10.3 F2 SMUG1
24 bladder sarcoma 10.3 ALB GPT
25 thymus small cell carcinoma 10.3 F2 SMUG1
26 brain stem glioma 10.3 F2 SMUG1
27 alpha 1-antitrypsin deficiency 10.3 ALB F2
28 autoimmune disease of cardiovascular system 10.3 ALB GGT2
29 tolosa-hunt syndrome 10.3 GGT1 GGT2
30 campylobacteriosis 10.3 GGT1 GPT
31 mixed mineral dust pneumoconiosis 10.3 ALB F2
32 liver rhabdomyosarcoma 10.3 ALB SMUG1
33 malignant visceral pleura tumor 10.3 GGT1 GGT2
34 limb ischemia 10.3 GGT1 GGT2
35 septal myocardial infarction 10.3 ALPP SMUG1
36 isolated growth hormone deficiency 10.3 ALB GPT
37 stenosis of lacrimal punctum 10.3 GGT1 GGT2
38 nasal cavity adenocarcinoma 10.3 ALB SMUG1
39 chorioangioma 10.3 GGT1 GGT2
40 adrenal gland disease 10.3 ALB SMUG1
41 meckel's diverticulum 10.3 ALB F2
42 rheumatic heart disease 10.3 F2 SMUG1
43 dermatomyositis 10.2 ALB GPT
44 polyarteritis nodosa 10.2 ALB SMUG1
45 acinar cell cystadenocarcinoma 10.2 GGT1 GGT2
46 autoimmune disease, multisystem, with facial dysmorphism 10.2 GGT1 GGT2
47 chronic inflammatory demyelinating polyradiculoneuropathy 10.2 ALB GGT1
48 patent foramen ovale 10.2 ALB GPT
49 uterus interstitial leiomyoma 10.2 ALB F2
50 hypertrophic elongation of cervix 10.2 GGT1 GGT2

Graphical network of the top 20 diseases related to Hepatic Tuberculosis:



Diseases related to Hepatic Tuberculosis

Symptoms & Phenotypes for Hepatic Tuberculosis

Drugs & Therapeutics for Hepatic Tuberculosis

Drugs for Hepatic Tuberculosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 79)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Rifampin Approved Phase 4,Phase 3,Phase 2 13292-46-1 5458213 5381226
2
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3 50-28-2 5757
3
Ethinyl Estradiol Approved Phase 4,Phase 3 57-63-6 5991
4
Moxifloxacin Approved, Investigational Phase 4,Phase 3 354812-41-2, 151096-09-2 152946
5
Norgestimate Approved Phase 4,Phase 3 35189-28-7 6540478
6 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1
7 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
8 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 3,Phase 2
9 Contraceptive Agents Phase 4,Phase 3
10 Contraceptives, Oral Phase 4,Phase 3
11 Contraceptives, Oral, Combined Phase 4,Phase 3
12 Estradiol 17 beta-cypionate Phase 4,Phase 3
13 Estradiol 3-benzoate Phase 4,Phase 3
14 Estradiol valerate Phase 4,Phase 3 979-32-8
15 Fluoroquinolones Phase 4,Phase 3
16 Norgestimate, ethinyl estradiol drug combination Phase 4,Phase 3
17 Polyestradiol phosphate Phase 4,Phase 3
18 Topoisomerase Inhibitors Phase 4,Phase 3
19
Efavirenz Approved, Investigational Phase 3 154598-52-4 64139
20
Lamivudine Approved, Investigational Phase 3 134678-17-4 60825
21
Nevirapine Approved Phase 3 129618-40-2 4463
22
Bedaquiline Approved Phase 3,Phase 1 843663-66-1
23
Ethambutol Approved Phase 2, Phase 3 74-55-5 3279 14052
24
Isoniazid Approved Phase 2, Phase 3, Phase 1 54-85-3 3767
25
Pyrazinamide Approved Phase 2, Phase 3 98-96-4 1046
26
Clofazimine Approved, Investigational Phase 3 2030-63-9 2794
27
Kanamycin Approved, Vet_approved Phase 3 8063-07-8, 59-01-8 6032
28
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
29
Ofloxacin Approved Phase 3 82419-36-1 4583
30
Prothionamide Investigational Phase 3 14222-60-7 666418
31 Antibiotics, Antitubercular Phase 3,Phase 2,Phase 1
32 Anti-HIV Agents Phase 3,Phase 2,Phase 1
33 Anti-Retroviral Agents Phase 3,Phase 2,Phase 1
34 Antitubercular Agents Phase 3,Phase 2,Phase 1
35 Antiviral Agents Phase 3,Phase 2,Phase 1
36 Cytochrome P-450 Enzyme Inhibitors Phase 3,Phase 2,Phase 1
37 Cytochrome P-450 CYP2C9 Inhibitors Phase 3
38 Cytochrome P-450 CYP3A Inducers Phase 3,Phase 2
39 Reverse Transcriptase Inhibitors Phase 3
40 Liver Extracts Phase 2, Phase 3
41 Diarylquinolines Phase 3,Phase 1
42 Antimetabolites Phase 2, Phase 3, Phase 1
43 Hypolipidemic Agents Phase 2, Phase 3, Phase 1
44 Lipid Regulating Agents Phase 2, Phase 3, Phase 1
45 Anti-Inflammatory Agents Phase 3
46 Cytochrome P-450 CYP1A2 Inhibitors Phase 3
47 Renal Agents Phase 3
48
Lopinavir Approved Phase 2 192725-17-0 92727
49
Rifabutin Approved Phase 2 72559-06-9 6323490
50
Ritonavir Approved, Investigational Phase 2 155213-67-5 392622

Interventional clinical trials:

(show all 15)

id Name Status NCT ID Phase Drugs
1 Pharmacokinetics and Safety of Moxifloxacin Terminated NCT01329250 Phase 4 Moxifloxacin
2 Efficacy and Safety of Concomitant Use of Nevirapine and Rifampicin With HIV-TB Completed NCT01805258 Phase 3 Nevirapine;Efavirenz
3 Efficacy of HUEXC030 in Subjects With Pulmonary Tuberculosis Recruiting NCT02467608 Phase 2, Phase 3 Isoniazid with HUEXC030 and RZE;HRZE
4 The Evaluation of a Standard Treatment Regimen of Anti-tuberculosis Drugs for Patients With MDR-TB Recruiting NCT02409290 Phase 3 Regimen A locally-used WHO-approved MDR-TB regimen;Moxifloxacin;Clofazimine;Ethambutol;Pyrazinamide;Isoniazid;Prothionamide;Kanamycin;Levofloxacin;Bedaquiline
5 EARNEST Rifabutin Pharmacokinetics (PK) Substudy Unknown status NCT01663168 Phase 2 Rifabutin
6 RIPE vs RIPE Plus N-acetylcysteine in Patients With HIV/TB Co-infection Recruiting NCT03281226 Phase 2 RIPE (2m) and RI (4m);RIPE+NAC (2m) and RI (4m)
7 A Study of TMC207 in Patients With Moderately Impaired Hepatic Function Completed NCT01012284 Phase 1 TMC207
8 Placebo-Controlled Trial of Safety and Efficacy of Thalidomide in Patients With Infections Due to Mycobacterium and/or HIV Completed NCT00002104 Phase 1 Thalidomide
9 Impact of Once-Weekly Rifapentine and Isoniazid on the Steady State Pharmacokinetics of Dolutegravir and Darunavir Boosted With Cobicistat in Healthy Volunteers Recruiting NCT02771249 Phase 1 rifapentene (RPT);darunavir/cobicistat (DRV/c);Isoniazid (INH)
10 Pharmacokinetics and Safety of PA-824 in Subjects With Mild, Moderate, and Severe Hepatic Impairment to Matched, Non-Hepatically Impaired Subjects Suspended NCT02422524 Phase 1 PA-824
11 Effect of Prophylactic Use of Silymarin on Hepatotoxicity Induced by Anti-tuberculosis Drugs Unknown status NCT01436929 Silymarin;Placebo
12 Investigation of the Effect of N Acetylcysteine Against Anti-Tuberculosis Drugs Induced Liver Toxicity Completed NCT00564642 N Acetylcysteine
13 A Retrospective Study on Drug Induced Liver Injury in China Completed NCT02407964
14 Hepatitis B in Cystic Fibrosis and Latent Tuberculosis Respectively Recruiting NCT02605538
15 Glycosylated Ferritin in Macrophagic Activation Syndromes Recruiting NCT02143986

Search NIH Clinical Center for Hepatic Tuberculosis

Cochrane evidence based reviews: tuberculosis, hepatic

Genetic Tests for Hepatic Tuberculosis

Anatomical Context for Hepatic Tuberculosis

MalaCards organs/tissues related to Hepatic Tuberculosis:

39
Liver, Skin, Lung, Colon

Publications for Hepatic Tuberculosis

Articles related to Hepatic Tuberculosis:

(show top 50) (show all 85)
id Title Authors Year
1
Isolated hepatic tuberculosis in the caudate lobe mimicking intrahepatic carcinoma. ( 28935504 )
2017
2
Hepatic tuberculosis in human immunodeficiency virus co-infected adults: a case series of South African adults. ( 28148232 )
2017
3
Concurrent Hepatic Tuberculosis and Hepatic Graft-versus-host Disease in an Allogeneic Hematopoietic Stem Cell Transplant Recipient: A Case Report. ( 28774674 )
2017
4
Erythema induratum of Bazin and PonAset's arthropathy as epiphenomena of hepatic tuberculosis. ( 26944370 )
2016
5
Isolated hepatic tuberculosis masquerading as hepatic metastasis in a patient with Ewing's sarcoma of fibula. ( 27146750 )
2016
6
Localized Hepatic Tuberculosis with Imaging Changes Caused by the Progression of Tuberculosis. ( 26984077 )
2016
7
A rare case of isolated macronodular hepatic tuberculosis (Tuberculous) in an immunocompetent patient. ( 26564302 )
2015
8
A systematic review of hepatic tuberculosis with considerations in human immunodeficiency virus co-infection. ( 25943103 )
2015
9
Hepatic tuberculosis mimicking metastasis in a case of carcinoma sigmoid colon. ( 25949064 )
2015
10
Hepatic Tuberculosis Mimicking Biliary Cystadenoma: A Radiological Dilemma. ( 26504607 )
2015
11
Hepatic tuberculosis: a multimodality imaging review. ( 26499189 )
2015
12
Primary/local hepatic tuberculosis without dissemination. ( 25628318 )
2015
13
Primary hepatic tuberculosis mimicking intrahepatic cholangiocarcinoma: report of two cases. ( 26236700 )
2015
14
Primary hepatic tuberculosis in immunocompetent adults: a UK case series. ( 25988061 )
2014
15
Isolated hepatic tuberculosis: a rare cause of hepatic mass lesions. ( 24918144 )
2014
16
Primary hepatic tuberculosis presenting as acute liver failure. ( 25988063 )
2014
17
Pulmonary tuberculosis combined with hepatic tuberculosis: a case report and literature review. ( 24865423 )
2014
18
Isolated hepatic tuberculosis mimicking liver tumors in a dialysis patient. ( 25123829 )
2014
19
Isolated hepatic tuberculosis: An uncommon presentation of a common culprit. ( 25031646 )
2014
20
Multiple hepatic lesions in a case of isolated hepatic tuberculosis simulating metastases on 18F-FDG PET/CT imaging. ( 25088112 )
2014
21
A case of multiple macronodular hepatic tuberculosis difficult to differentiate from hepatocellular carcinoma with intrahepatic metastasis: CT-guided fine needle aspiration biopsy confirmed the diagnosis. ( 25550879 )
2014
22
Co-existence of hepatocellular carcinoma and hepatic tuberculosis. ( 24476016 )
2014
23
Hepatic Tuberculosis Mimics Metastasis Revealed by 18F-FDG PET/CT. ( 24152632 )
2013
24
Probable hepatic tuberculosis masquerading as Klatskin tumour in an immunocompetent patient. ( 24343799 )
2013
25
Diagnosis and treatment of hepatic tuberculosis: report of five cases and review of literature. ( 24179582 )
2013
26
The liver Metastatic Adenocarcinoma of Colorectal Cancer With Synchronous Isolated Hepatic Tuberculosis. ( 23967026 )
2013
27
Hepatic tuberculosis: a rare cause of fluorodeoxyglucose hepatic superscan with background suppression on positron emission tomography. ( 24347039 )
2013
28
Primary isolated hepatic tuberculosis. ( 23673179 )
2013
29
Hepatic tuberculosis presenting with extreme hyperferritinemia masquerading as adult-onset Still's disease: a case report. ( 22788693 )
2012
30
Pseudo-tumoral hepatic tuberculosis discovered after surgical resection. ( 24765426 )
2012
31
Primary hepatic tuberculosis: a rare but fatal clinical entity if undiagnosed. ( 22575985 )
2012
32
Hepatic tuberculosis in a patient treated with infliximab. ( 21793022 )
2011
33
The nodular form of hepatic tuberculosis: contrast-enhanced ultrasonographic findings with pathologic correlation. ( 20498462 )
2010
34
Corticosteroids in the treatment of hepatic tuberculosis: case report and review of the literature. ( 20092380 )
2010
35
Pseudotumoral hepatic tuberculosis with pericardial abscess. ( 21045410 )
2010
36
Pseudo-tumoral hepatic tuberculosis: a report of two cases. ( 20306917 )
2010
37
Radiological findings of isolated hepatic tuberculosis in a child with tubulointerstitial nephritis-uveitis syndrome. ( 19137283 )
2009
38
Primary hepatic tuberculosis in an immunocompetent patient: the Great Mimic. ( 19795040 )
2009
39
Primary nodular hepatic tuberculosis mimicking hepatic neoplasia in an immunocompetent host. ( 20140362 )
2009
40
Granulomatous hepatitis: tuberculosis or not? ( 18241177 )
2008
41
Isolated hepatic tuberculosis. ( 20071827 )
2008
42
Isolated hepatic tuberculosis presenting as cystic-like and tumour-like mass lesions. ( 21490832 )
2008
43
CT appearance of primary localized nodular hepatic tuberculosis in an immunocompetent patient. ( 18541946 )
2008
44
Hepatic tuberculosis mimicking Klatskin tumor: a diagnostic dilemma. ( 18723964 )
2008
45
Macronodular hepatic tuberculosis necessitating hepatic resection: a diagnostic conundrum. ( 18031627 )
2007
46
Localized hepatic tuberculosis presenting as fever of unknown origin. ( 17293928 )
2006
47
Hepatic tuberculosis in absence of disseminated abdominal tuberculosis. ( 16531964 )
2006
48
Hypercalcemia in hepatic tuberculosis: a case report in Korea. ( 15827271 )
2005
49
Hepatic tuberculosis mimicking carcinoma gall bladder. ( 15778524 )
2005
50
Macronodular hepatic tuberculosis associated with portal vein thrombosis and portal hypertension. ( 16026440 )
2005

Variations for Hepatic Tuberculosis

Expression for Hepatic Tuberculosis

Search GEO for disease gene expression data for Hepatic Tuberculosis.

Pathways for Hepatic Tuberculosis

GO Terms for Hepatic Tuberculosis

Cellular components related to Hepatic Tuberculosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.55 ALB F2 GGT1 GPT SERPINA1
2 platelet alpha granule lumen GO:0031093 9.26 ALB SERPINA1
3 endoplasmic reticulum lumen GO:0005788 9.13 ALB F2 SERPINA1
4 extracellular exosome GO:0070062 9.1 ALB F2 GGT1 GGT2 GPT SERPINA1

Biological processes related to Hepatic Tuberculosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.33 ALB F2 SERPINA1
2 hemostasis GO:0007599 9.32 F2 SERPINA1
3 acute-phase response GO:0006953 9.26 F2 SERPINA1
4 zymogen activation GO:0031638 8.96 GGT1 GGT2
5 glutathione catabolic process GO:0006751 8.62 GGT1 GGT2

Molecular functions related to Hepatic Tuberculosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 pyridoxal phosphate binding GO:0030170 8.96 ALB GPT
2 glutathione hydrolase activity GO:0036374 8.62 GGT1 GGT2

Sources for Hepatic Tuberculosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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