MCID: HPT002
MIFTS: 46

Hepatic Vein Thrombosis malady

Cardiovascular diseases, Blood diseases categories

Summaries for Hepatic Vein Thrombosis

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Wikipedia:65 Budd?Chiari syndrome is a condition caused by occlusion of the hepatic veins that drain the liver. It... more...

MalaCards based summary: Hepatic Vein Thrombosis, also known as budd-chiari syndrome, is related to portal vein thrombosis and protein c deficiency. An important gene associated with Hepatic Vein Thrombosis is PIGA (phosphatidylinositol glycan anchor biosynthesis, class A), and among its related pathways are Collagen biosynthesis and modifying enzymes and Complement and coagulation cascades. The drugs antithrombin iii, human and antithrombin iii,recombinant and the compounds dihydrotestosterone and batroxobin have been mentioned in the context of this disorder. Affiliated tissues include liver, and related mouse phenotypes are embryogenesis and liver/biliary system.

Aliases & Classifications for Hepatic Vein Thrombosis

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Hepatic Vein Thrombosis, Aliases & Descriptions:

Name: Hepatic Vein Thrombosis 10 12 62
Budd-Chiari Syndrome 10 62
Sinusoidal Obstruction Syndrome 62
 
Hepatic Veno-Occlusive Disease 62
Hepatic Vein Obstruction 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases, Blood diseases


External Ids:

Disease Ontology10 DOID:11512
SNOMED-CT57 38739001, 195436007
MeSH35 D006502

Related Diseases for Hepatic Vein Thrombosis

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Diseases related to Hepatic Vein Thrombosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 113)
idRelated DiseaseScoreTop Affiliating Genes
1portal vein thrombosis31.3PROS1, F5
2protein c deficiency30.8SERPINE1, PROS1, F5
3antiphospholipid syndrome30.8PROS1, F5
4protein s deficiency30.5PROS1, F5, SERPINE1
5sagittal sinus thrombosis30.3F5, PROS1
6pulmonary embolism30.3F5, PROS1
7lupus erythematosus30.3F5, PROS1
8thrombophilia30.3SERPINE1, PROS1, F5
9hyperhomocysteinemia30.3F5, PROS1, SERPINE1
10thrombocytopenia30.2F5, PIGA
11hepatitis11.1
12budd-chiari syndrome10.8
13echinococcosis10.6
14hepatopulmonary syndrome10.5
15alveolar echinococcosis10.5
16leukemia10.5
17ulcerative colitis10.5
18colitis10.5
19cholangiocarcinoma10.5
20liver cirrhosis10.5
21thrombocytosis10.5
22intrahepatic cholangiocarcinoma10.5
23essential thrombocythemia10.5
24nodular regenerative hyperplasia10.5
25hepatocellular carcinoma10.4
26alcoholic liver cirrhosis10.4
27hemangioma10.4
28relapsing polychondritis10.4
29polyarteritis nodosa10.4
30protein-losing enteropathy10.4
31cerebritis10.4
32intravenous leiomyomatosis10.4
33leiomyomatosis10.4
34hemangioendothelioma10.4
35f5-related budd-chiari syndrome10.4
36jak2-related budd-chiari syndrome10.4
37epithelioid hemangioendothelioma10.4
38paroxysmal nocturnal hemoglobinuria10.3
39portal hypertension10.3
40hemoglobinuria10.3
41systemic lupus erythematosus10.2
42polycystic liver disease10.2
43neuroblastoma10.2
44acute liver failure10.2
45autoimmune hepatitis10.2
46liver disease10.2
47thalassemia10.2
48neuroectodermal tumor10.2
49gaucher's disease10.2
50diabetic ketoacidosis10.2

Graphical network of the top 20 diseases related to Hepatic Vein Thrombosis:



Diseases related to hepatic vein thrombosis

Symptoms for Hepatic Vein Thrombosis

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Drugs & Therapeutics for Hepatic Vein Thrombosis

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Drug clinical trials:

Search ClinicalTrials for Hepatic Vein Thrombosis

Search NIH Clinical Center for Hepatic Vein Thrombosis

Inferred drug relations via UMLS62/NDF-RT41:

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Genetic Tests for Hepatic Vein Thrombosis

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Anatomical Context for Hepatic Vein Thrombosis

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MalaCards organs/tissues related to Hepatic Vein Thrombosis:

33
Liver

Animal Models for Hepatic Vein Thrombosis or affiliated genes

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MGI Mouse Phenotypes related to Hepatic Vein Thrombosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053808.5F5, PROS1, PIGA
2MP:00053708.4F5, PROS1, SERPINE1
3MP:00107718.0F5, PROS1, SERPINE1, PIGA
4MP:00107687.7PIGA, SERPINE1, PROS1, F5

Publications for Hepatic Vein Thrombosis

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Articles related to Hepatic Vein Thrombosis:

(show top 50)    (show all 73)
idTitleAuthorsYear
1
Gastrointestinal Variant of Lemierre Syndrome: Fusobacterium nucleatum Bacteremia-Associated Hepatic Vein Thrombosis: a Case Report and Literature Review. (24942004)
2014
2
Japanese case of Budd-Chiari syndrome due to hepatic vein thrombosis successfully treated with liver transplantation. (22248193)
2012
3
Subcapsular hepatic hematoma with right hepatic vein thrombosis: a complication of shock wave lithotripsy. (18542735)
2008
4
Hepatic vein thrombosis as a complication of ulcerative colitis in a 12-year-old patient. (17372822)
2007
5
Infliximab in the treatment of hepatic vein thrombosis (Budd-Chiari syndrome) in three patients with Behcet's syndrome. (17478465)
2007
6
Portal and hepatic vein thrombosis in liver abscess: CT findings. (17161932)
2007
7
Pivotal role of PAI-1 in a murine model of hepatic vein thrombosis. (16160004)
2006
8
Severe thrombophilic diathesis starting with hepatic vein thrombosis (BUDD-CHIARI syndrome) in a family with a new Protein S gene mutation. (16673558)
2006
9
Acute hepatic vein thrombosis after liver transplantation in a child with biliary atresia and absent inferior vena cava. (16797332)
2006
10
Familial high factor VIII level associated with hepatic vein thrombosis. (15319659)
2004
11
Hepatic vein thrombosis (Budd-Chiari syndrome). (11928075)
2002
12
Portal or hepatic vein thrombosis as the first presentation of a myeloproliferative disorder in patients with normal peripheral blood counts. (12181028)
2002
13
Hepatic vein thrombosis with ulcerative colitis. (10918734)
2000
14
Segmental hepatic vein thrombosis associated with heparin-induced thrombocytopenia II. (10664167)
2000
15
Hepatic vein thrombosis in a patient with mutant prothrombin 20210A allele. (9759637)
1998
16
Proposal of a new nomenclature for Budd-Chiari syndrome: hepatic vein thrombosis versus thrombosis of the inferior vena cava at its hepatic portion. (9794901)
1998
17
Prevalence of the factor V Leiden mutation in portal and hepatic vein thrombosis. (9771422)
1998
18
Reassessing the role of medical therapy in the management of hepatic vein thrombosis. (9346773)
1997
19
Prospective evaluation of the prevalence of factor V Leiden mutation in portal or hepatic vein thrombosis. (9365003)
1997
20
Balloon occlusion portography to diagnose new-onset left hepatic vein thrombosis and widening of an existing Wallstent TIPS by Palmaz stents for recurrent portal hypertension and variceal bleeding. (8781163)
1996
21
Budd-Chiari syndrome caused by hepatic vein thrombosis in a patient with myeloproliferative disorder. (8968799)
1996
22
Successful systemic thrombolysis of hepatic vein thrombosis in a patient with promyelocytic leukemia treated with all-trans retinoic acid. (7717385)
1995
23
Tissue plasminogen activator for hepatic vein thrombosis in paroxysmal nocturnal haemoglobinuria. (8283166)
1994
24
Thrombotic cutaneous nodules and hepatic vein thrombosis in the anticardiolipin syndrome. (2591097)
1989
25
Hepatic vein thrombosis (Budd-Chiari syndrome) in the microgranular variant of acute promyelocytic leukemia. (2773853)
1989
26
Recovery from hepatic vein thrombosis (Budd-Chiari syndrome) complicating ulcerative colitis. (3197587)
1988
27
Hepatic vein thrombosis in paroxysmal nocturnal hemoglobinuria. A spectrum from asymptomatic occlusion of hepatic venules to fatal Budd-Chiari syndrome. (3609666)
1987
28
Risk of hepatic vein thrombosis in relation to recent use of oral contraceptives. A case-control study. (3949113)
1986
29
Primary myeloproliferative disorder and hepatic vein thrombosis. A prospective study of erythroid colony formation in vitro in 20 patients with Budd-Chiari syndrome. (4026081)
1985
30
Ultrasonography: hepatic vein thrombosis in sickle cell anemia. (7114404)
1982
31
Oral contraceptives and hepatic vein thrombosis. (7205808)
1981
32
Veno-occlusive disease and primary hepatic vein thrombosis in Israeli Arabs. (7263190)
1981
33
Case report: hepatic vein thrombosis (acute Budd-Chiari syndrome) in acute leukemia. (6947690)
1981
34
"Dimple sign" in hepatic vein thrombosis. (465948)
1979
35
Acute hepatic vein thrombosis occurring during therapy for Hodgkin's disease: a case report. (509400)
1979
36
Activation of the Hageman factor-prekallikrein system in the pathogenesis of the generalized Shwartzman reaction and of the hepatic vein thrombosis phenomenon in the rat. (470342)
1979
37
Hepatic vein thrombosis: a case presentation and retrospective study. (225035)
1979
38
Inferior vena cava and hepatic vein thrombosis as a rare complication of ventriculoatrial shunt. Case report. (619017)
1978
39
Hepatic vein thrombosis in a woman taking oral contraceptives: a case report. (903688)
1977
40
Acute hepatic vein thrombosis in a patient with Behcet's disease. (829359)
1976
41
Hepatic vein thrombosis in Buffalo strain female rats ingesting dimethylnitrosamine. (1187201)
1975
42
Activation of Hageman factor and initiation of hepatic vein thrombosis in the hyperlipemic rat. (4843381)
1974
43
Hepatic vein thrombosis in children in the Near East. (5054003)
1972
44
Hepatic vein thrombosis (Budd-Chiari syndrome). (5445577)
1970
45
Hepatic vein thrombosis. Increased incidence in rats given methylcholanthrene and carbon tetrachloride. (5450122)
1970
46
Severe cirrhosis with hepatic vein thrombosis in rats given carbon tetrachloride and 3-methylcholanthrene. (5711263)
1968
47
Hepatic vein thrombosis complicating polycythemia vera. Successful treatment with a portacaval shunt. (6028691)
1967
48
MYOMA-ERYTHROCYTOSIS SYNDROME, PRESENTING WITH ACUTE HEPATIC VEIN THROMBOSIS. (14269124)
1965
49
Chiari's disease, hepatic-vein thrombosis. (14941265)
1952
50
Case report of stenosis of the vena cava with vena caval and hepatic vein thrombosis reto trauma. (14933990)
1952

Variations for Hepatic Vein Thrombosis

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Expression for genes affiliated with Hepatic Vein Thrombosis

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Search GEO for disease gene expression data for Hepatic Vein Thrombosis.

Pathways for genes affiliated with Hepatic Vein Thrombosis

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Compounds for genes affiliated with Hepatic Vein Thrombosis

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Compounds related to Hepatic Vein Thrombosis according to GeneCards/GeneDecks:

(show all 38)
idCompoundScoreTop Affiliating Genes
1dihydrotestosterone45 30 26 1312.6SERPINE1, PROS1
2batroxobin459.6F5, SERPINE1
3ancrod459.5F5, SERPINE1
4tibolone459.5SERPINE1, F5
5cyproteroneacetate459.5F5, SERPINE1
6desmopressin45 61 30 1312.5SERPINE1, F5
7hirudin459.5F5, SERPINE1
8protamine459.5F5, SERPINE1
9mycophenolate mofetil45 51 1311.5SERPINE1, F5
10raloxifene45 51 30 1312.5F5, SERPINE1
11kininogen459.5F5, SERPINE1
12glucosylceramide45 2610.5PIGA, F5
13metformin45 51 1311.5SERPINE1, F5
14pge1459.5SERPINE1, F5
15aprotinin45 1310.4F5, SERPINE1
16gamma-carboxyglutamic acid459.4PROS1, F5
17uric acid45 2610.4F5, SERPINE1
18progestin459.4SERPINE1, F5
19sodium dodecylsulfate459.4F5, SERPINE1
20homocysteine45 2610.4SERPINE1, F5
21atorvastatin45 51 30 26 1313.4F5, SERPINE1
22simvastatin45 51 61 30 26 1314.3F5, SERPINE1
23vitamin d459.3PROS1, SERPINE1
24vitamin-e459.3F5, PROS1
25endotoxin459.3F5, SERPINE1
26tacrolimus45 51 1311.3SERPINE1, F5
27aspirin45 51 30 2612.2F5, SERPINE1
28phospholipid459.0F5, PROS1
29fibrinogen459.0F5, SERPINE1
30cyclophosphamide45 51 1311.0PIGA, SERPINE1, F5
31prostacyclin458.9F5, PROS1, SERPINE1
32creatinine458.9F5, PROS1, SERPINE1
33heparin45 30 26 1311.9SERPINE1, PROS1, F5
34testosterone45 61 26 1311.9SERPINE1, PROS1, F5
35cholesterol45 30 26 1311.9F5, PROS1, SERPINE1
36vegf458.8F5, PROS1, SERPINE1
37paclitaxel45 51 1310.7F5, PROS1
38serine458.6SERPINE1, PROS1, F5

GO Terms for genes affiliated with Hepatic Vein Thrombosis

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Cellular components related to Hepatic Vein Thrombosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055768.5F5, PROS1, SERPINE1
2platelet alpha granule lumenGO:00310938.2F5, PROS1, SERPINE1

Biological processes related to Hepatic Vein Thrombosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1post-translational protein modificationGO:00436879.3PROS1, PIGA
2fibrinolysisGO:00427309.3SERPINE1, PROS1
3negative regulation of endopeptidase activityGO:00109519.0PROS1, SERPINE1
4platelet degranulationGO:00025768.6F5, PROS1, SERPINE1
5platelet activationGO:00301688.6F5, PROS1, SERPINE1
6blood coagulationGO:00075968.4F5, PROS1, SERPINE1

Products for genes affiliated with Hepatic Vein Thrombosis

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Sources for Hepatic Vein Thrombosis

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet