MCID: HPT021
MIFTS: 65

Hepatitis malady

Gastrointestinal category

Summaries for Hepatitis

Sources:
34MedlinePlus, 64Wikipedia, 33MalaCards
See all sources

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MedlinePlus:34 Your liver is the largest organ inside your body. it helps your body digest food, store energy, and remove poisons. hepatitis is an inflammation of the liver. viruses cause most cases of hepatitis. the type of hepatitis is named for the virus that causes it; for example, hepatitis a, hepatitis b or hepatitis c. drug or alcohol use can also cause hepatitis. in other cases, your body mistakenly attacks healthy cells in the liver. some people who have hepatitis have no symptoms. others may have loss of appetite nausea and vomiting diarrhea dark-colored urine and pale bowel movements stomach pain jaundice, yellowing of skin and eyes some forms of hepatitis are mild, and others can be serious. some can lead to scarring, called cirrhosis, or to liver cancer. sometimes hepatitis goes away by itself. if it does not, it can be treated with drugs. sometimes hepatitis lasts a lifetime. vaccines can help prevent some viral forms.

MalaCards: Hepatitis, also known as chronic persistent hepatitis, is related to hepatitis b and insulin resistance. An important gene associated with Hepatitis is LIPC (lipase, hepatic), and among its related pathways are Regulation of beta-cell development and Type II diabetes mellitus. The drugs astragalus preparation and milk thistle extract and the compounds lipid and fatty acid have been mentioned in the context of this disorder.

Wikipedia:64 Hepatitis (plural: hepatitides) is a medical condition defined by the inflammation of the liver and... more...

Aliases & Classifications for Hepatitis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 34MedlinePlus, 31LifeMap Discovery™, 61UMLS, 57SNOMED-CT, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal


Aliases & Descriptions:

hepatitis 8 10 45 34 31 61
chronic persistent hepatitis 8 45
acute hepatitis 8 61
acute and subacute liver necrosis nos 8
acute and subacute necrosis of liver 8
acute and subacute liver necrosis 8
acute/subac. necrosis of liver 8
hepatitis, chronic persistent 61
chronic persistant hepatitis 8
hepatitis, chronic 61
chronic hepatitis 8
hepatitis chronic 45
hepatitis, animal 61
animal hepatitis 8


Related Diseases for Hepatitis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the hepatitis c family:

hepatitis e hepatitis b
autoimmune hepatitis hepatitis d
hepatitis a hepatitis
viral hepatitis hepatitis c virus

Diseases related to Hepatitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1422)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis b31.9HNF1A, HNF4A, LAMTOR5, RSF1, ASGR1, ASGR2
2insulin resistance31.1HNF1A, HNF4A, HNF1B, LIPC, ANGPTL4
3polycystic kidney disease30.6PKHD1
4atherosclerosis30.5LIPC, HNF4A
5glucose intolerance30.4HNF1A, HNF4A, HNF1B, LIPC
6primary hyperoxaluria30.3LIPC, PKHD1, HNF1B, HNF4A, HNF1A
7polycystic kidney disease, autosomal recessive30.2PKHD1, HNF1B, HNF1A
8hyperinsulinism30.0LIPC, HNF1B, HNF4A
9type 1 diabetes29.9LIPC, HNF4A, HNF1A
10polycystic kidney and hepatic disease29.8PKHD1
11type 2 diabetes mellitus29.8HNF1A, HNF4A, HNF1B, LIPC
12familial adenomatous polyposis29.4RARB, FMO3, HNF4A
13hepatitis c11.6
14hepatitis a11.6
15hepatitis c virus11.4
16hepatitis d11.4
17hepatitis e11.4
18viral hepatitis11.2
19autoimmune hepatitis11.1
20alcoholic hepatitis11.0
21hepatic coma11.0
22hepatitis b virus infection10.9
23cryoglobulinemia10.8
24congenital hepatic fibrosis10.8
25granulomatous hepatitis10.8
26adenoma10.7
27hepatic angiomyolipoma10.7
28angiomyolipoma10.7
29hepatic vein thrombosis10.7
30tuberculosis10.6
31drug-induced hepatitis10.6
32hemangioendothelioma10.6
33acute liver failure10.6
34porphyria cutanea tarda10.6
35primary biliary cirrhosis10.6
36hepatic tuberculosis10.6
37n syndrome10.6
38fatty liver disease10.6
39fulminant viral hepatitis10.6
40portal hypertension10.6
41nonalcoholic steatohepatitis10.6
42epithelioid hemangioendothelioma10.6
43membranoproliferative glomerulonephritis10.5
44colorectal cancer10.5
45biliary atresia10.5
46vasculitis10.5
47lichen planus10.5
48syphilis10.5
49polyarteritis nodosa10.5
50tetanus10.5

Graphical network of the top 20 diseases related to Hepatitis:



Diseases related to hepatitis

Clinical Features for Hepatitis

Drugs & Therapeutics for Hepatitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Hepatitis

Drug clinical trials:

Search ClinicalTrials for Hepatitis

Search NIH Clinical Center for Hepatitis

Search CenterWatch for Hepatitis

Inferred drug relations via UMLS61/NDF-RT41:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Hepatitis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Hepatitis:
Promethera
Embryonic/Adult Cultured Cells Related to Hepatitis:
Adult liver progenitor cells, PMIDs: 22525602, 23211283, 19091822, 24142276, 22900053

Genetic Tests for Hepatitis

Anatomical Context for Hepatitis

Animal Models for Hepatitis or affiliated genes

Sources:
28inGenious Targeting Laboratory
See all sources

Publications for Hepatitis

Sources:
51PubMed
See all sources

Articles related to Hepatitis:

(show top 50)    (show all 13979)
idTitleAuthorsYear
1
Hepatitis B Surface Antigen Level Complements Viral load in Predicting Viral Reactivation in Spontaneous HBeAg Seroconverters. (24384028)
2014
2
Impact of occult hepatitis B virus infection or hepatitis B virus DNA integration on efficacy of chronic hepatitis C treatment with peginterferon and ribavirin: where are we? (24045272)
2014
3
Apolipoprotein E Codetermines Tissue Tropism of Hepatitis C Virus and Is Crucial for Viral Cell-to-Cell Transmission by Contributing to a Postenvelopment Step of Assembly. (24173232)
2014
4
IFNL4-I9G Genotype Is Associated With Slower Viral Clearance in Hepatitis C, Genotype-1 Patients Treated With Sofosbuvir and Ribavirin. (24367041)
2014
5
Hepatic Immune Regulation and its Involvement in Viral Hepatitis Infection. (24412289)
2014
6
Human cytidine deaminases facilitate hepatitis B virus evolution and link inflammation and hepatocellular carcinoma. (24120759)
2014
7
A Simple Noninvasive Score Based on Routine Parameters can Predict Liver Cirrhosis in Patients With Chronic Hepatitis C. (23967022)
2013
8
Albendazole-induced Recurrent Hepatitis. (24382909)
2013
9
Hepatitis C recurrence: the Achilles heel of liver transplantation. (24372756)
2013
10
Hepatitis A outbreak in Bijeljina, Bosnia and Herzegovina, August 2012 - April 2013. (23725978)
2013
11
Disclosure behaviour and experienced reactions in patients with HIV versus chronic viral hepatitis or diabetes mellitus in Germany. (23383628)
2013
12
A genome-wide association study identifies polymorphisms in the HLA-DR region associated with non-response to hepatitis B vaccination in Chinese Han populations. (24282030)
2013
13
Replication of hepatitis E virus in three-dimensional cell culture. (23159673)
2013
14
Human and experimental evidence supporting a role for osteopontin in alcoholic hepatitis. (23729174)
2013
15
Female Sexual Dysfunction Among Egyptian Patients with Chronic Hepatitis C. (24283464)
2013
16
Comment on the British Society of Gastroenterology guidelines for management of autoimmune hepatitis (part 1). (22634113)
2012
17
A marked decrease in CD4-positive lymphocytes at the onset of hepatitis in a patient with hepatitis-associated aplastic anemia. (22246160)
2012
18
Single-nucleotide polymorphism at CYP27B1-1260, but not VDR Taq I, is possibly associated with persistent hepatitis B virus infection. (22963605)
2012
19
Autoimmune hepatitis from the paediatric perspective. (22093323)
2011
20
IL-28B predicts response to chronic hepatitis C therapy--fine-mapping and replication study in Asian populations. (21228123)
2011
21
Prevalence and clinical significance of hepatitis D virus co-infection in patients with chronic hepatitis B in Korea. (21541950)
2011
22
Persistent expression of the full genome of hepatitis C virus in B cells induces spontaneous development of B-cell lymphomas in vivo. (20733156)
2010
23
Hepatitis C virus core protein induces neuroimmune activation and potentiates Human Immunodeficiency Virus-1 neurotoxicity. (20877724)
2010
24
The potential role of insulin-like growth factor 1, insulin-like growth factor binding protein 3 and bone mineral density in patients with chronic hepatitis C virus in Cairo, Egypt. (20189618)
2010
25
Hepatitis B virus X protein overcomes the growth-inhibitory potential of retinoic acid by downregulating retinoic acid receptor-beta2 expression via DNA methylation. (19828754)
2010
26
Hepatitis C virus-infected hepatocytes extrinsically modulate dendritic cell maturation to activate T cells and natural killer cells. (18537195)
2008
27
Hepatitis E virus as an etiology of acute exacerbation of previously unrecognized asymptomatic patients with hepatitis B virus-related chronic liver disease. (18070014)
2008
28
Effective etanercept treatment for psoriatic arthritis complicating concomitant human immunodeficiency virus and hepatitis C virus infection. (17552060)
2007
29
Limited suppression of the interferon-beta production by hepatitis C virus serine protease in cultured human hepatocytes. (17651439)
2007
30
Bell's palsy and hepatitis infection. (16970789)
2006
31
Hepatopulmonary syndrome: an emerging complication in HIV-hepatitis C virus co-infected patients. (16868454)
2006
32
Hepatitis C virus-specific immune responses and quasi-species variability at baseline are associated with nonresponse to antiviral therapy during advanced hepatitis C. (16518754)
2006
33
Serum level of transforming growth factor-beta1 (TGF-beta1) and the expression of TGF-beta receptor type II in peripheral blood mononuclear cells in patients with autoimmune hepatitis. (15532825)
2004
34
Hepatitis B virus X gene induces human telomerase reverse transcriptase mRNA expression in cultured normal human cholangiocytes. (15259077)
2004
35
Longterm course of mixed cryoglobulinemia in patients infected with hepatitis C virus. (15517633)
2004
36
Malarial hepatitis. (15260391)
2003
37
Mitochondrial aspartate glutamate carrier (citrin) deficiency as the cause of adult-onset type II citrullinemia (CTLN2) and idiopathic neonatal hepatitis (NICCD). (12111366)
2002
38
Terbinafine-induced hepatitis and pancytopenia. (11508672)
2001
39
Hepatitis C virus core protein-induced loss of LZIP function correlates with cellular transformation. (10675342)
2000
40
The lymphoid system in hepatitis C virus infection: autoimmunity, mixed cryoglobulinemia, and Overt B-cell malignancy. (10946420)
2000
41
Kinetics of serum soluble tumour necrosis factor receptor (TNF-R) type-I and type-II after a single interferon-alpha (IFN-alpha) injection in chronic hepatitis C. (10469062)
1999
42
Phylogenetic analysis to document a common source of hepatitis D virus infection in a mother and her child. (10063709)
1999
43
Serum level of interleukin-4 is a possible marker of therapeutic response to interferon treatment in patients with chronic hepatitis C. (10453958)
1999
44
Incidence and characteristics of thyroid dysfunction following interferon therapy in patients with chronic hepatitis C. (9617858)
1998
45
Hepatic histology of patients with HIV infection and chronic hepatitis C treated with interferon. (9389973)
1997
46
Cytokine mediators in acute inflammation and chronic course of viral hepatitis]. (7727201)
1995
47
Epidermodysplasia verruciformis. Skin carcinoma containing human papillomavirus type 5 DNA sequences and primary hepatocellular carcinoma associated with chronic hepatitis B virus infection in a patient. (2426900)
1986
48
Sensitisation to Mallory bodies (alcoholic hyalin) in alcoholic hepatitis. (6161947)
1981
49
Steroid treatment of alcoholic hepatitis. The yeas and the nays. (620902)
1978
50
Exchange transfusion and corticosteroids in the treatment of acute viral hepatitis hepatic coma. (1223069)
1975

Genetic Variations for Hepatitis

Expression for genes affiliated with Hepatitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Hepatitis

Search GEO for disease gene expression data for Hepatitis.

Pathways for genes affiliated with Hepatitis

Sources:
54Reactome, 30KEGG, 50PharmGKB, 12EMD Millipore
See all sources

Pathways related to Hepatitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.2HNF1B, HNF4A, HNF1A
2
Hide members
11.2HNF1B, HNF4A, HNF1A
3
Dichloroethylene metabolism
Hide members
11.0HNF4A, HNF1A

Compounds for genes affiliated with Hepatitis

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB
See all sources

Compounds related to Hepatitis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1lipid4512.6RSF1, HNF1A, HNF4A, AKR1C1, LIPC, ANGPTL4
2fatty acid4511.7HNF1A, HNF4A, LIPC, ANGPTL4, ASGR2
3steroid4511.7RARB, LIPC, AKR1C1, HNF4A, HNF1A
4cholesterol45 29 11 2414.4HNF1A, HNF4A, HNF1B, LIPC, ANGPTL4
5c-peptide4511.1LIPC, HNF4A, HNF1A
6nnmt4511.0HNF1B, HNF1A

GO Terms for genes affiliated with Hepatitis

Sources:
16Gene Ontology
See all sources

Biological processes related to Hepatitis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1triglyceride homeostasisGO:07032811.5ANGPTL4, LIPC, HNF4A
2endocrine pancreas developmentGO:03101811.4HNF1A, HNF4A, HNF1B
3response to glucose stimulusGO:00974911.4HNF1B, HNF4A, HNF1A
4xenobiotic metabolic processGO:00680511.2AKR1C1, FMO3, HNF4A
5regulation of pronephros sizeGO:03556511.2HNF1B, HNF1A
6positive regulation of transcription initiation from RNA polymerase II promoterGO:06026111.1HNF1B, HNF1A
7regulation of Wnt receptor signaling pathwayGO:03011111.1HNF1A, HNF1B
8SMAD protein signal transductionGO:06039511.0HNF1A, HNF4A
9lipid homeostasisGO:05508811.0HNF4A, ASGR2
10reverse cholesterol transportGO:04369110.9HNF1A, LIPC
11bile acid and bile salt transportGO:01572110.7HNF1A, AKR1C1

Molecular functions related to Hepatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551513.5HNF4A, HNF1B, CCDC85B, PKHD1, ANGPTL4, RARB
2asialoglycoprotein receptor activityGO:00487310.7ASGR2, ASGR1

Products for genes affiliated with Hepatitis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hepatitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet