MCID: HPT021
MIFTS: 75

Hepatitis malady

Gastrointestinal diseases, Liver diseases categories

Summaries for Hepatitis

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Sources:
33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Your liver is the largest organ inside your body. it helps your body digest food, store energy, and remove poisons. hepatitis is an inflammation of the liver. viruses cause most cases of hepatitis. the type of hepatitis is named for the virus that causes it; for example, hepatitis a, hepatitis b or hepatitis c. drug or alcohol use can also cause hepatitis. in other cases, your body mistakenly attacks healthy cells in the liver. some people who have hepatitis have no symptoms. others may have loss of appetite nausea and vomiting diarrhea dark-colored urine and pale bowel movements stomach pain jaundice, yellowing of skin and eyes some forms of hepatitis are mild, and others can be serious. some can lead to scarring, called cirrhosis, or to liver cancer. sometimes hepatitis goes away by itself. if it does not, it can be treated with drugs. sometimes hepatitis lasts a lifetime. vaccines can help prevent some viral forms.

MalaCards: Hepatitis, also known as chronic persistent hepatitis, is related to hepatitis b and hepatocellular carcinoma. An important gene associated with Hepatitis is LIPC (lipase, hepatic), and among its related pathways are Regulation of beta-cell development and Type II diabetes mellitus. The drugs astragalus preparation and milk thistle extract and the compounds lipid and fatty acid have been mentioned in the context of this disorder. Affiliated tissues include liver, t cells and kidney.

Wikipedia:63 Hepatitis (plural: hepatitides) is a medical condition defined by the inflammation of the liver and... more...

Aliases & Classifications for Hepatitis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 30LifeMap Discovery™, 60UMLS, 56SNOMED-CT, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases, Liver diseases


Aliases & Descriptions:

hepatitis 8 10 44 33 30 60
chronic persistent hepatitis 8 44
acute hepatitis 8 60
acute and subacute liver necrosis nos 8
acute and subacute necrosis of liver 8
acute and subacute liver necrosis 8
acute/subac. necrosis of liver 8
hepatitis, chronic persistent 60
chronic persistant hepatitis 8
hepatitis, chronic 60
chronic hepatitis 8
hepatitis chronic 44
hepatitis, animal 60
animal hepatitis 8


Related Diseases for Hepatitis

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Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Hepatitis C family:

Hepatitis E Hepatitis B
Autoimmune Hepatitis Hepatitis D
Hepatitis a hepatitis
Viral Hepatitis Hepatitis C Virus

Diseases related to Hepatitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1369)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis b32.2HNF1A, HNF4A, LAMTOR5, RSF1, ASGR1, ASGR2
2hepatocellular carcinoma31.6HNF1A, HNF4A, HNF1B, LIPC, RARB, RSF1
3liver cirrhosis31.3ASGR2, RSF1
4obesity31.0HNF1A, HNF4A, AKR1C1, LIPC, ANGPTL4
5polycystic kidney disease30.6PKHD1
6atherosclerosis30.5LIPC, HNF4A
7hepatoblastoma30.4HNF1A, HNF4A
8glucose intolerance30.4HNF1A, HNF4A, HNF1B, LIPC
9type 2 diabetes mellitus30.3HNF1A, HNF4A, HNF1B, LIPC
10hyperglycemia30.3LIPC, HNF1B, HNF4A, HNF1A
11primary hyperoxaluria30.3LIPC, PKHD1, HNF1B, HNF4A, HNF1A
12galactosemia30.3HNF4A, HNF1B, PKHD1, LIPC, RSF1, ASGR2
13polycystic kidney disease, autosomal recessive30.2PKHD1, HNF1B, HNF1A
14hyperinsulinism30.0LIPC, HNF1B, HNF4A
15maturity-onset diabetes of the young29.9HNF1A, HNF4A, HNF1B
16cystic kidney29.8PKHD1, HNF1B
17polycystic kidney and hepatic disease29.8PKHD1
18ovarian cancer29.7HNF4A, HNF1B, AKR1C1, RARB
19kidney cancer29.6HNF1A, HNF4A, HNF1B, RARB
20familial adenomatous polyposis29.4RARB, FMO3, HNF4A
21hepatitis c11.5
22hepatitis a11.5
23viral hepatitis11.2
24autoimmune hepatitis11.1
25hepatitis e11.1
26alcoholic hepatitis11.0
27hepatic encephalopathy11.0
28hepatic coma11.0
29hepatitis d11.0
30liver disease11.0
31cryoglobulinemia10.8
32granulomatous hepatitis10.8
33congenital hepatic fibrosis10.8
34porphyria10.7
35glomerulonephritis10.7
36adenoma10.7
37hepatic vein thrombosis10.7
38hepatic angiomyolipoma10.7
39angiomyolipoma10.7
40pancreatitis10.7
41hepatic tuberculosis10.6
42drug-induced hepatitis10.6
43thyroiditis10.6
44tuberculosis10.6
45hypertension10.6
46acute liver failure10.6
47porphyria cutanea tarda10.6
48primary biliary cirrhosis10.6
49cholestasis10.6
50cholangiocarcinoma10.6

Graphical network of the top 20 diseases related to Hepatitis:



Diseases related to hepatitis

Clinical Features for Hepatitis

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Drugs & Therapeutics for Hepatitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Hepatitis

Drug clinical trials:

Search ClinicalTrials for Hepatitis

Search NIH Clinical Center for Hepatitis

Search CenterWatch for Hepatitis

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Hepatitis cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Hepatitis:
Promethera
Embryonic/Adult Cultured Cells Related to Hepatitis:
Adult liver progenitor cells, PMIDs: 22525602, 23211283, 19091822, 24142276, 22900053

Genetic Tests for Hepatitis

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Anatomical Context for Hepatitis

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Sources:
32MalaCards
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MalaCards organs/tissues related to Hepatitis:

32
Liver, T cells, Kidney, Testes, Brain, Thyroid, B cells, Bone, Endothelial, Bone marrow, Monocytes, Skin, Heart, Colon, Lung, Eye, Nk cells, Pancreas, Breast, Myeloid, Lymph node, Prostate, Ovary, Cortex, Pituitary, Spleen, Smooth muscle, Fetal liver, Spinal cord, Salivary gland, Pancreatic islet, Whole blood, Small intestine, Tongue, Skeletal muscle, Adrenal cortex, Hypothalamus, Cerebellum, Adipocyte, Prefrontal cortex, Trachea, Globus pallidus, Thalamus, Adrenal gland, Testis, Placenta, Thymus, Cingulate cortex

Animal Models for Hepatitis or affiliated genes

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Publications for Hepatitis

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Sources:
50PubMed
See all sources

Articles related to Hepatitis:

(show top 50)    (show all 22364)
idTitleAuthorsYear
1
Hepatitis C virus core+1/ARF protein decreases hepcidin transcription through an AP1 binding site. (23580428)
2013
2
Bone marrow suppression or active proliferation? An analysis of neutropenia after pegylated interferon treatment of patients with chronic hepatitis C. (24090457)
2013
3
Chimeric hepatitis E virus-like particle as a carrier for oral-delivery. (23107594)
2013
4
The role of high mobility group box chromosomal protein 1 expression in the differential diagnosis of hepatic actinomycosis: a case report. (23351605)
2013
5
Increase in spleen volume of rats on experimental model of pre-hepatic portal hypertension. (24190379)
2013
6
Antiviral activities of Indonesian medicinal plants in the East Java region against hepatitis C virus. (24089993)
2013
7
Keratin 8 is involved in hepatitis B virus replication. (24375072)
2013
8
Peg-IFNI+/ribavirin/protease inhibitor combination in hepatitis C virus associated mixed cryoglobulinemia vasculitis: results at week 24. (23606708)
2013
9
Refractory hypocalcemia precipitated by dual infection with typhoid fever and hepatitis A in a patient with congenital hypoparathyroidism. (22840459)
2012
10
Experience in primary hepatic neuroendocrine tumor. (23161300)
2012
11
Hepatic portal venous gas associated with severe graft-versus-host disease of the gastrointestinal tract. (22975560)
2012
12
Effects of contact dermatitis on hepatic gene expression in broilers. (23130578)
2012
13
Viral hepatitis induces hepatocellular cancer: what can we learn from epidemiology comparing iran and worldwide findings? (23233866)
2012
14
Impact of patatin-like phospholipase-3 (rs738409 C>G) polymorphism on fibrosis progression and steatosis in chronic hepatitis C. (21488075)
2011
15
Simultaneously developed polymyositis and autoimmune hepatitis. (22674111)
2011
16
I+-2-HS-glycoprotein is a potential marker predicting hepatitis B e antigen seroconversion in patients with chronic hepatitis B during treatment with pegylated interferon alpha-2b. (21253869)
2011
17
Infectivity of hepatitis C virus is influenced by association with apolipoprotein E isoforms. (20826689)
2010
18
Testing for HIV, sexually transmitted infections, and viral hepatitis in jails: still a missed opportunity for public health and HIV prevention. (21406992)
2010
19
Elevations in alanine aminotransferase levels late in the course of antiviral therapy in hepatitis C virus RNA-negative patients are associated with virological relapse. (19350657)
2009
20
Incipient primary biliary cirrhosis/autoimmune hepatitis overlap or hepatitic form of primary biliary cirrhosis: a case report. (19829977)
2009
21
Influence of a single nucleotide polymorphism in the P1 promoter of the furin gene on transcription activity and hepatitis B virus infection. (19492430)
2009
22
Multiple variants in toll-like receptor 4 gene modulate risk of liver fibrosis in Caucasians with chronic hepatitis C infection. (19586676)
2009
23
Alcohol-induced alterations in hepatic microtubule dynamics can be explained by impaired histone deacetylase 6 function. (18697214)
2008
24
Evaluation of quantitative portal venous, hepatic arterial, and total hepatic tissue blood flow using xenon CT in alcoholic liver cirrhosis: comparison with liver cirrhosis C. (17331165)
2007
25
Rupture of hepatic aneurysm complicating hereditary hemorrhagic telangiectasia (Osler-Weber-Rendu disease) for which hepatic arterial coil embolization was effective. (18031399)
2007
26
Treatment of chronic hepatitis B with the combination of pegylated interferon with lamivudine. (17627637)
2007
27
Combined immunologic and anti-angiogenic therapy reduces hepatic micrometastases in a murine ocular melanoma model. (16769615)
2006
28
Postchemotherapy characteristics of hepatic colorectal metastases: remnants of uncertain malignant potential. (16627212)
2006
29
Transcriptional repression of hepatic cytochrome P450 3A4 gene in the presence of cancer. (17189422)
2006
30
Activation of AMP-activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders. (16644802)
2006
31
Clinical significance of elevated alpha-fetoprotein (AFP) in patients with chronic hepatitis C, but not hepatocellular carcinoma. (15128351)
2004
32
Hepatitis C core and nonstructural 3 proteins trigger toll-like receptor 2-mediated pathways and inflammatory activation. (15521019)
2004
33
Clinical and pathological differences between alcoholic hepatitis and non-alcoholic steatohepatitis. (12687723)
2003
34
Contribution of obesity to hepatitis C-related fibrosis progression. (12358265)
2002
35
Hepatitis C virus core protein induces cell proliferation and activates ERK, JNK, and p38 MAP kinases together with the MAP kinase phosphatase MKP-1 in a HepG2 Tet-Off cell line. (11878930)
2002
36
Expression of transmembrane 4 superfamily (TM4SF) proteins and their role in hepatic stellate cell motility and wound healing migration. (12175627)
2002
37
Polyunsaturated fatty acids stimulate hepatic UCP-2 expression via a PPARalpha-mediated pathway. (11701434)
2001
38
Hepatic adenoma associated with recombinant human growth hormone therapy in a patient with Turner's syndrome. (11155014)
2000
39
Comparative analysis of plasma lipoprotein components assessed by ultracentrifugation in primary biliary cirrhosis and chronic hepatitis. (11208331)
2000
40
Ruptured hepatic adenoma in liver adenomatosis: a case report of emergency surgical management. (10430373)
1999
41
Hepatitis D viremia following orthotopic liver transplantation involves a typical HDV virion with a hepatitis B surface antigen envelope. (9620349)
1998
42
Intrahepatic splenosis mimicking hepatic adenoma. (9057523)
1997
43
Prevalence of hepatitis B or C virus infection in patients with fulminant viral hepatitis. An analysis using polymerase chain reaction. (8778190)
1996
44
Natural history of hepatitis D viral superinfection: significance of viremia detected by polymerase chain reaction. (7875481)
1995
45
Hepatic reactions in the course of viral meningoencephalitis in patients hospitalized in 1985-1989]. (8249395)
1993
46
Polycystic hepatic disease, thoracic granular cell tumor and secondary hypertrophic osteopathy in a horse. (8403922)
1993
47
Modulation of perisinusoidal cell cytoskeletal features during experimental hepatic fibrosis. (8465518)
1993
48
Primary biliary cirrhosis: relation between hepatic function and pulmonary function in patients who never smoked. (2050328)
1991
49
Congenital hepatic fibrosis: evolving morphology. (3224022)
1988
50
Hepatic injury from chronic hypervitaminosis a resulting in portal hypertension and ascites. (4843409)
1974

Genetic Variations for Hepatitis

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Expression for genes affiliated with Hepatitis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hepatitis

Search GEO for disease gene expression data for Hepatitis.

Pathways for genes affiliated with Hepatitis

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Sources:
53Reactome, 29KEGG, 49PharmGKB, 12EMD Millipore
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Pathways related to Hepatitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.2HNF1B, HNF4A, HNF1A
2
Hide members
11.2HNF1B, HNF4A, HNF1A
3
Dichloroethylene metabolism
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11.0HNF4A, HNF1A

Compounds for genes affiliated with Hepatitis

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB
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Compounds related to Hepatitis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1lipid4412.6RSF1, HNF1A, HNF4A, AKR1C1, LIPC, ANGPTL4
2fatty acid4411.7HNF1A, HNF4A, LIPC, ANGPTL4, ASGR2
3steroid4411.7RARB, LIPC, AKR1C1, HNF4A, HNF1A
4cholesterol44 28 11 2414.4HNF1A, HNF4A, HNF1B, LIPC, ANGPTL4
5c-peptide4411.1LIPC, HNF4A, HNF1A
6nnmt4411.0HNF1B, HNF1A

GO Terms for genes affiliated with Hepatitis

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Sources:
16Gene Ontology
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Biological processes related to Hepatitis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1triglyceride homeostasisGO:07032811.5ANGPTL4, LIPC, HNF4A
2endocrine pancreas developmentGO:03101811.4HNF1A, HNF4A, HNF1B
3response to glucose stimulusGO:00974911.4HNF1B, HNF4A, HNF1A
4xenobiotic metabolic processGO:00680511.2AKR1C1, FMO3, HNF4A
5regulation of pronephros sizeGO:03556511.2HNF1B, HNF1A
6positive regulation of transcription initiation from RNA polymerase II promoterGO:06026111.1HNF1B, HNF1A
7regulation of Wnt receptor signaling pathwayGO:03011111.1HNF1A, HNF1B
8SMAD protein signal transductionGO:06039511.0HNF1A, HNF4A
9lipid homeostasisGO:05508811.0HNF4A, ASGR2
10reverse cholesterol transportGO:04369110.9HNF1A, LIPC
11bile acid and bile salt transportGO:01572110.7HNF1A, AKR1C1

Molecular functions related to Hepatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551513.5HNF4A, HNF1B, CCDC85B, PKHD1, ANGPTL4, RARB
2asialoglycoprotein receptor activityGO:00487310.7ASGR2, ASGR1

Products for genes affiliated with Hepatitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hepatitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet