MCID: HPT003
MIFTS: 59

Hepatitis a malady

Infectious diseases, Liver diseases, Gastrointestinal diseases, Rare diseases, Immune diseases categories
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Summaries for Hepatitis a

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MedlinePlus:33 Your liver is the largest organ inside your body. it helps your body digest food, store energy, and remove poisons. hepatitis is an inflammation of the liver. one type, hepatitis a, is caused by the hepatitis a virus (hav). the disease spreads through contact with an infected person's stool. you can get it from eating food made by an infected person who did not wash their hands after using the bathroom drinking untreated water or eating food washed in untreated water putting into your mouth a finger or object that came into contact with an infected person's stool having close contact with an infected person, such as through sex or caring for someone who is ill most people do not have any symptoms. if you do have symptoms, you may feel as if you have the flu. you may also have yellowish eyes and skin, called jaundice. a blood test will show if you have hav. hav usually gets better in a few weeks without treatment. however, some people can have symptoms for up to 6 months. your doctor may suggest medicines to help relieve your symptoms. the hepatitis a vaccine can prevent hav. good hygiene can also help. wash your hands thoroughly before preparing food, after using the toilet, or after changing a diaper. international travelers should be careful about drinking tap water. nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary: Hepatitis a, also known as viral hepatitis, type a, is related to hepatitis and alcoholic hepatitis, and has symptoms including An important gene associated with Hepatitis a is HAVCR1 (hepatitis A virus cellular receptor 1), and among its related pathways are IL4-mediated signaling events and Inflammatory Response Pathway. The compounds isoniazid and monoethylglycinexylidide have been mentioned in the context of this disorder. Affiliated tissues include liver, liver and skin, and related mouse phenotype hematopoietic system.

Disease Ontology:8 A viral infectious disease that results in inflammation located in liver, has material basis in hepatitis a virus, which is transmitted by ingestion of contaminated food or water, or transmitted by direct contact with an infected person. the infection has symptom fever, has symptom fatigue, has symptom loss of appetite, has symptom nausea, has symptom vomiting, has symptom abdominal pain, has symptom clay-colored bowel movements, has symptom joint pain, and has symptom jaundice.

Wikipedia:65 Hepatitis A (formerly known as infectious hepatitis) is an acute infectious disease of the liver caused... more...

Aliases & Classifications for Hepatitis a

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Hepatitis a, Aliases & Descriptions:

Name: Hepatitis a 8 10 33 62
 
Viral Hepatitis, Type a 8


Classifications:



External Ids:

Disease Ontology8 DOID:12549
MeSH34 D006506
SNOMED-CT57 154347003, 40468003
NCIt39 C3096
ICD1025 B15.0, B15.9

Related Diseases for Hepatitis a

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Diseases in the Hepatitis C family:

Autoimmune Hepatitis Hepatitis
Hepatitis B Hepatitis D
hepatitis a Hepatitis E
Viral Hepatitis Hepatitis C Virus
Susceptibility to Hepatitis Due to Voriconazole Treatment Susceptibility to Hepatitis Due to Flucloxacilline Treatment

Diseases related to Hepatitis a via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 176)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis32.2F2, GPT
2alcoholic hepatitis31.4GPT, F2
3viral hepatitis31.4G6PD, GPT, F2
4autoimmune hepatitis31.2CD40LG, GPT, F2
5cholecystitis31.1GPT
6hepatitis b31.0GPT, F2
7hepatitis e31.0GPT, CD40LG
8acute liver failure30.8F2, GPT
9autoimmune hemolytic anemia30.7G6PD, CD40LG
10hepatitis c30.7CD40LG, GPT, F2
11malaria30.5TPI1, G6PD
12hemolytic anemia30.5G6PD, TPI1
13infectious mononucleosis30.4TPI1, CD40LG
14cholestasis30.4GPT, F2
15hemorrhagic fever30.4CD40LG
16plasmodium falciparum malaria30.3G6PD, TPI1
17thrombocytopenia30.3CD40LG, GPT, F2
18scrub typhus30.2GPT, CD40LG
19vasculitis30.1CD40LG, F2
20galactosemia30.0F2, GPT
21primary biliary cirrhosis29.9F2, GPT, CD40LG
22diabetes mellitus29.8GPT, G6PD, CD40LG
23lupus erythematosus29.8CD40LG, F2
24choledocholithiasis10.5GPT
25mediterranean spotted fever10.5G6PD
26typhoid fever10.4
27granulomatous hepatitis10.4
28wilson disease10.3G6PD, GPT
29portal hypertension10.3GPT, F2
30hepatic encephalopathy10.3GPT, F2
31acute kidney failure10.3GPT, G6PD
32blood protein disease10.3F2, CD40LG
33alcoholic liver cirrhosis10.3F2, GPT
34acalculous cholecystitis10.3
35congenital hemolytic anemia10.3G6PD, TPI1
36bilirubin metabolic disorder10.3G6PD, F2
37hepatitis c virus10.2
38blindness10.2
39fulminant viral hepatitis10.2
40pregnancy loss10.2CD40LG, F2
41antiphospholipid syndrome10.2CD40LG, F2
42thromboembolism10.2F2, G6PD
43leukopenia10.2F2, GPT
44pure red-cell aplasia10.2
45mumps10.2
46influenza10.2
47liver disease10.2
48rubella10.2
49measles10.2
50purpura10.2

Graphical network of the top 20 diseases related to Hepatitis a:



Diseases related to hepatitis a

Symptoms for Hepatitis a

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Drugs & Therapeutics for Hepatitis a

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Drug clinical trials:

Search ClinicalTrials for Hepatitis a

Search NIH Clinical Center for Hepatitis a

Genetic Tests for Hepatitis a

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Anatomical Context for Hepatitis a

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MalaCards organs/tissues related to Hepatitis a:

32
Liver, Skin, Testes, Kidney, Eye, T cells, Thyroid, Heart, Pancreas, B cells, Endothelial

FMA organs/tissues related to Hepatitis a:

14
Liver

Animal Models for Hepatitis a or affiliated genes

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MGI Mouse Phenotypes related to Hepatitis a:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.4CD40LG, G6PD, TPI1, HAVCR1, F2

Publications for Hepatitis a

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Articles related to Hepatitis a:

(show top 50)    (show all 774)
idTitleAuthorsYear
1
Pure red-cell aplasia and autoimmune hemolytic anemia in a patient with acute hepatitis A. (25032187)
2014
2
A case of acute motor and sensory axonal neuropathy following hepatitis a infection. (24339719)
2013
3
Isolation and characterization of a low pathogenic duck hepatitis A virus 3 from South Korea. (23265242)
2013
4
Pseudothrombocytopenia or platelet clumping as a possible cause of low platelet count in patients with viral infection: a case series from single institution focusing on hepatitis A virus infection. (22958573)
2013
5
Seroprevalence of anti-hepatitis a antibody among 1 - 15 year old children in kashan-iran. (23967019)
2013
6
Survival of murine norovirus, Tulane virus, and hepatitis A virus on alfalfa seeds and sprouts during storage and germination. (24014537)
2013
7
Oral fluid and hepatitis A, B and C: a literature review. (22188507)
2012
8
Randomized trial: immunogenicity and safety of coadministered human papillomavirus-16/18 AS04-adjuvanted vaccine and combined hepatitis A and B vaccine in girls. (22188832)
2012
9
A case of severe acute hepatitis a complicated with pure red cell aplasia. (23018540)
2012
10
The depuration dynamics of oysters (Crassostrea gigas) artificially contaminated with hepatitis A virus and human adenovirus. (22310530)
2012
11
Model-based projections of the population-level impact of hepatitis A vaccination in Mexico. (22854667)
2012
12
Responses to hepatitis A virus vaccine in HIV-infected women: effect of hormonal contraceptives and HIV disease characteristics. (22517417)
2012
13
The role of immunoglobulin A in prolonged and relapsing hepatitis A virus infections. (22170633)
2012
14
Could oral fluid be used to evaluate anti-hepatitis A virus status in individuals living in difficult-to-access areas? (22910286)
2012
15
Expression of recombinant rotavirus proteins harboring antigenic epitopes of the hepatitis a virus polyprotein in insect cells. (24130930)
2012
16
Hepatitis A. Information from your family doctor. (23198676)
2012
17
A multistate outbreak of hepatitis A associated with semidried tomatoes in Australia, 2009. (22238166)
2012
18
Distribution of copper, iron, and zinc in biological samples (scalp hair, serum, blood, and urine) of Pakistani viral hepatitis (A-E) patients and controls. (20872092)
2011
19
Change in hepatitis A epidemiology after vaccinating high risk children in Taiwan, 1995-2008. (21329774)
2011
20
The Seroconversion Rate of Hepatitis A Virus Vaccination among Patients with Hepatitis B Virus-Related Chronic Liver Disease in Korea. (21814604)
2011
21
Acute hepatitis A virus infection is associated with a limited type I interferon response and persistence of intrahepatic viral RNA. (21690403)
2011
22
Recommendations for administering hepatitis A vaccine to contacts of international adoptees. (21949136)
2011
23
CYP3A4*18 polymorphisms and anti-hepatitis A virus seroprevalence. (21940338)
2011
24
Evaluation of calcium, magnesium, potassium, and sodium in biological samples of Pakistani viral hepatitis (A-E) patients and controls. (21755830)
2011
25
Seroprevalence and correlates of hepatitis a among HIV-negative American men who have sex with men. (21851774)
2011
26
Antibody persistence and immune memory in healthy adults following vaccination with a two-dose inactivated hepatitis A vaccine: long-term follow-up at 15 years. (21915861)
2011
27
Hepatitis A associated with semidried tomatoes, France, 2010. (21392466)
2011
28
MEMS biosensor for detection of Hepatitis A and C viruses in serum. (21803562)
2011
29
Jaundice after radical cholecystectomy and bile duct resection: a case of postoperative acute viral hepatitis a confounding the clinical picture. (22942614)
2011
30
Antioxidant defense and oxidative stress in children with acute hepatitis A. (21623054)
2011
31
Treatment of chronic delta hepatitis: a nine-year retrospective analysis. (22235216)
2011
32
Decline in HAV-associated fulminant hepatic failure and liver transplant in children in Argentina after the introduction of a universal hepatitis A vaccination program. (24367225)
2011
33
Expression of a recombinant chimeric protein of hepatitis A virus VP1-Fc using a replicating vector based on Beet curly top virus in tobacco leaves and its immunogenicity in mice. (21442402)
2011
34
Meningoencephalitis associated with hepatitis A infection: a case report and review of literature. (20555050)
2010
35
Nitric oxide levels and sustained virological response to pegylated-interferon alpha2a plus ribavirin in chronic HCV genotype 4 hepatitis: A prospective study. (21188329)
2010
36
Childhood hepatitis A virus infection complicated by pseudotumor cerebri. (19139677)
2009
37
Markers for hepatitis A, B and C in methadone maintained patients: an unexpectedly high co-infection with silent hepatitis B. (18339114)
2008
38
Hepatitis A super infection as a cause of liver failure in a child with Wilson's disease. (17907522)
2007
39
Adenosine deaminase activity in serum of patients with hepatitis -- a useful tool in monitoring clinical status. (17712462)
2007
40
Influence of load of hepatitis A virus on disease severity and its relationship with clinical manifestations in patients with hepatitis A. (16048563)
2005
41
A case of autoimmune hepatitis and autoimmune hemolytic anemia following hepatitis A infection. (14655068)
2003
42
Characteristics of cellular immunity in children with acute viral hepatitis A]. (14708438)
2003
43
An open randomized study of inactivated hepatitis A vaccine administered concomitantly with typhoid fever and yellow fever vaccines. (12044272)
2002
44
Hepatitis A infection mimicking adult onset Still's disease. (10914871)
2000
45
Serious hepatitis A: an analysis of patients hospitalized during an urban epidemic in the United States. (9441570)
1998
46
Licensed preparations against hepatitis A and chickenpox: vaccine update--Part 2. (9051961)
1996
47
Determination of the inactivation kinetics of hepatitis A virus in human plasma products using a simple TCID50 assay. (8732864)
1996
48
Mononeuritis multiplex: a rare complication of acute hepatitis A. (8878003)
1996
49
Do corticosteroids reduce mortality from alcoholic hepatitis? A meta-analysis of the randomized trials. (2142869)
1990
50
Lassa virus hepatitis: a study of fatal Lassa fever in humans. (3953952)
1986

Variations for Hepatitis a

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Expression for genes affiliated with Hepatitis a

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Expression patterns in normal tissues for genes affiliated with Hepatitis a

Search GEO for disease gene expression data for Hepatitis a.

Pathways for genes affiliated with Hepatitis a

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Pathways related to Hepatitis a according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4CD40LG, IGHG3
29.2CD40LG, IGHA1
3
Show member pathways
L-serine degradation37
pentose phosphate pathway (oxidative branch)37
formaldehyde oxidation II (glutathione-dependent)37
9.2G6PD, TPI1, GPT

Compounds for genes affiliated with Hepatitis a

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Compounds related to Hepatitis a according to GeneCards/GeneDecks:

(show top 50)    (show all 64)
idCompoundScoreTop Affiliating Genes
1isoniazid44 50 1112.1G6PD, GPT
2monoethylglycinexylidide4410.1F2, GPT
3hepaplastin4410.1F2, GPT
46-phosphogluconate4410.1G6PD, GPT
5ximelagatran44 1111.1GPT, F2
6aminopyrine4410.1GPT, F2
7alpha-tocopheryl acetate4410.1G6PD, F2
8gemfibrozil28 44 1112.0GPT, G6PD
9sulfamethoxazole50 44 1112.0CD40LG, G6PD
10clarithromycin44 1111.0F2, GPT
11ppack4410.0CD40LG, F2
12tirofiban44 1111.0CD40LG, F2
13lamivudine44 50 1112.0F2, GPT
14fructose-1,6-bisphosphate4410.0G6PD, TPI1
15glutaraldehyde449.9G6PD, CD40LG
16diamide449.9TPI1, G6PD
17sulfasalazine28 44 50 1112.9CD40LG, G6PD
18abciximab44 1110.9CD40LG, F2
19isocitrate449.9G6PD, TPI1
20clopidogrel44 50 24 1112.8CD40LG, F2
21cardiolipin44 1110.8CD40LG, F2
22hirudin449.8F2, CD40LG
23silymarin449.8GPT, F2
24valproate449.8CD40LG, GPT
25ribavirin44 50 1111.8CD40LG, G6PD, GPT
26vitamin b12449.8CD40LG, G6PD, GPT
27Pyridoxal 5'-phosphate249.8G6PD, GPT
28thyroxine44 2410.8CD40LG, G6PD, GPT
29acetaminophen44 2 50 24 1113.7F2, GPT, G6PD
30mycophenolate mofetil44 50 1111.7GPT, CD40LG
31ursodeoxycholic acid44 24 1111.7F2, GPT, CD40LG
32malate449.7GPT, TPI1, G6PD
33hyaluronic acid44 2410.7F2, GPT, CD40LG
34polyethylene glycol449.7CD40LG, G6PD, F2
35alpha tocopherol449.7G6PD, TPI1, GPT
36phosphatidylserine44 28 1111.6F2, G6PD, CD40LG
37pyruvate449.6G6PD, TPI1, GPT
38aspirin44 50 28 2412.6CD40LG, G6PD, F2
39epinephrine44 24 1111.6F2, G6PD, CD40LG
40fibrinogen449.5CD40LG, GPT, F2
41glycerol 3-phosphate44 2410.5G6PD, TPI1
42tamoxifen44 50 28 1112.4CTRL, G6PD, F2
43n acetylcysteine449.3CD40LG, G6PD, GPT, F2
44actinomycin d449.3CD40LG, G6PD, TPI1
45adenylate449.2GPT, TPI1, G6PD, CD40LG
46cyclosporin a44 28 6111.0CD40LG, GPT, F2
47lactate448.8CD40LG, G6PD, TPI1, GPT, F2
48creatinine448.8F2, GPT, TPI1, G6PD, CD40LG
49aspartate448.8CD40LG, G6PD, TPI1, GPT, F2
50serine448.6F2, TPI1, G6PD, CD40LG, CTRL

GO Terms for genes affiliated with Hepatitis a

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Cellular components related to Hepatitis a according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:0725628.6IGHA1, IGHG3, F2
2extracellular spaceGO:0056156.8CTRL, CD40LG, TPI1, IGHA1, IGHG3, F2

Biological processes related to Hepatitis a according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1pentose-phosphate shuntGO:0060989.3G6PD, TPI1
2retina homeostasisGO:0018959.0IGHA1, IGHG3

Molecular functions related to Hepatitis a according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1antigen bindingGO:0038239.0IGHA1, IGHG3

Products for genes affiliated with Hepatitis a

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  • Antibodies
  • Proteins
  • Lysates

Sources for Hepatitis a

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet