MCID: HPT003
MIFTS: 58

Hepatitis a malady

Infectious diseases, Liver diseases, Gastrointestinal diseases, Rare diseases, Immune diseases categories
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Summaries for Hepatitis a

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Sources:
8Disease Ontology, 34MedlinePlus, 65Wikipedia, 33MalaCards
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MedlinePlus:34 Your liver is the largest organ inside your body. it helps your body digest food, store energy, and remove poisons. hepatitis is an inflammation of the liver. one type, hepatitis a, is caused by the hepatitis a virus (hav). the disease spreads through contact with an infected person's stool. you can get it from eating food made by an infected person who did not wash their hands after using the bathroom drinking untreated water or eating food washed in untreated water putting into your mouth a finger or object that came into contact with an infected person's stool having close contact with an infected person, such as through sex or caring for someone who is ill most people do not have any symptoms. if you do have symptoms, you may feel as if you have the flu. you may also have yellowish eyes and skin, called jaundice. a blood test will show if you have hav. hav usually gets better in a few weeks without treatment. however, some people can have symptoms for up to 6 months. your doctor may suggest medicines to help relieve your symptoms. the hepatitis a vaccine can prevent hav. good hygiene can also help. wash your hands thoroughly before preparing food, after using the toilet, or after changing a diaper. international travelers should be careful about drinking tap water. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Hepatitis a, also known as viral hepatitis, type a, is related to hepatitis and viral hepatitis, and has symptoms including fatigue, loss of appetite and nausea. An important gene associated with Hepatitis a is HAVCR1 (hepatitis A virus cellular receptor 1), and among its related pathways are IL4-mediated signaling events and Inflammatory Response Pathway. The compounds isoniazid and monoethylglycinexylidide have been mentioned in the context of this disorder. Affiliated tissues include liver, liver and skin, and related mouse phenotype hematopoietic system.

Disease Ontology:8 A viral infectious disease that results in inflammation located in liver, has material basis in hepatitis a virus, which is transmitted by ingestion of contaminated food or water, or transmitted by direct contact with an infected person. the infection has symptom fever, has symptom fatigue, has symptom loss of appetite, has symptom nausea, has symptom vomiting, has symptom abdominal pain, has symptom clay-colored bowel movements, has symptom joint pain, and has symptom jaundice.

Wikipedia:65 Hepatitis A (formerly known as infectious hepatitis) is an acute infectious disease of the liver caused... more...

Aliases & Classifications for Hepatitis a

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8Disease Ontology, 10DISEASES, 34MedlinePlus, 62UMLS, 40NCIt, 58SNOMED-CT, 35MeSH, 25ICD10
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Classifications:



Aliases & Descriptions:

hepatitis a 8 10 34 62
viral hepatitis, type a 8


External Ids:

Disease Ontology8 DOID:12549
NCIt40 C3096
SNOMED-CT58 154347003, 40468003
MeSH35 D006506
ICD1025 B15.0, B15.9

Related Diseases for Hepatitis a

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Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Hepatitis C family:

Autoimmune Hepatitis Hepatitis B
Hepatitis D hepatitis a
Hepatitis E Hepatitis
Viral Hepatitis Hepatitis C Virus

Diseases related to Hepatitis a via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 170)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis31.9F2, GPT
2viral hepatitis31.2F2, GPT, G6PD
3alcoholic hepatitis31.0GPT, F2
4autoimmune hepatitis31.0F2, CD40LG, GPT
5hepatitis b30.7F2, GPT
6hepatitis e30.6CD40LG, GPT
7cholecystitis30.6GPT
8hepatitis c30.5F2, GPT, CD40LG
9acute liver failure30.4GPT, F2
10cholestasis30.3GPT, F2
11autoimmune hemolytic anemia30.3CD40LG, G6PD
12malaria30.2G6PD, TPI1
13hemolytic anemia30.2G6PD, TPI1
14infectious mononucleosis30.1TPI1, CD40LG
15thrombocytopenia30.1CD40LG, GPT, F2
16plasmodium falciparum malaria30.0G6PD, TPI1
17vasculitis30.0F2, CD40LG
18hemorrhagic fever29.9CD40LG
19scrub typhus29.8CD40LG, GPT
20galactosemia29.8GPT, F2
21primary biliary cirrhosis29.7GPT, F2, CD40LG
22diabetes mellitus29.7G6PD, GPT, CD40LG
23lupus erythematosus29.7CD40LG, F2
24granulomatous hepatitis10.3
25typhoid fever10.3
26acalculous cholecystitis10.3
27hepatitis c virus10.2
28fulminant viral hepatitis10.2
29mumps10.2
30influenza10.2
31blindness10.2
32rubella10.2
33pure red-cell aplasia10.2
34measles10.2
35liver disease10.2
36purpura10.2
37choledocholithiasis10.1GPT
38mediterranean spotted fever10.1G6PD
39acute disseminated encephalomyelitis10.1
40diphtheria10.1
41encephalomyelitis10.1
42hepatocellular carcinoma10.1
43tetanus10.1
44wilson disease10.1GPT, G6PD
45portal hypertension10.1F2, GPT
46hepatic encephalopathy10.1GPT, F2
47acute kidney failure10.1GPT, G6PD
48blood protein disease10.1CD40LG, F2
49alcoholic liver cirrhosis10.1GPT, F2
50congenital hemolytic anemia10.1TPI1, G6PD

Graphical network of the top 20 diseases related to Hepatitis a:



Diseases related to hepatitis a

Symptoms for Hepatitis a

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Sources:
8Disease Ontology
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Symptoms:

8 (show all 9)
  • fatigue
  • loss of appetite
  • nausea
  • vomiting
  • abdominal pain
  • clay-colored bowel movements
  • joint pain
  • jaundice
  • fever

Drugs & Therapeutics for Hepatitis a

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Hepatitis a

Search NIH Clinical Center for Hepatitis a

Genetic Tests for Hepatitis a

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Anatomical Context for Hepatitis a

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Sources:
33MalaCards, 14FMA
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MalaCards organs/tissues related to Hepatitis a:

33
Liver, Skin, Testes, Kidney, Eye, T cells, Thyroid, Heart, B cells, Endothelial, Pancreas

FMA organs/tissues related to Hepatitis a:

14
Liver

Animal Models for Hepatitis a or affiliated genes

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Sources:
37MGI
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MGI Mouse Phenotypes related to Hepatitis a:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.4CD40LG, G6PD, TPI1, HAVCR1, F2

Publications for Hepatitis a

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Sources:
52PubMed
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Articles related to Hepatitis a:

(show top 50)    (show all 750)
idTitleAuthorsYear
1
A case of acute motor and sensory axonal neuropathy following hepatitis a infection. (24339719)
2013
2
Isolation and characterization of a low pathogenic duck hepatitis A virus 3 from South Korea. (23265242)
2013
3
Pseudothrombocytopenia or platelet clumping as a possible cause of low platelet count in patients with viral infection: a case series from single institution focusing on hepatitis A virus infection. (22958573)
2013
4
Seroprevalence of anti-hepatitis a antibody among 1 - 15 year old children in kashan-iran. (23967019)
2013
5
Survival of murine norovirus, Tulane virus, and hepatitis A virus on alfalfa seeds and sprouts during storage and germination. (24014537)
2013
6
Oral fluid and hepatitis A, B and C: a literature review. (22188507)
2012
7
Randomized trial: immunogenicity and safety of coadministered human papillomavirus-16/18 AS04-adjuvanted vaccine and combined hepatitis A and B vaccine in girls. (22188832)
2012
8
A case of severe acute hepatitis a complicated with pure red cell aplasia. (23018540)
2012
9
The depuration dynamics of oysters (Crassostrea gigas) artificially contaminated with hepatitis A virus and human adenovirus. (22310530)
2012
10
Model-based projections of the population-level impact of hepatitis A vaccination in Mexico. (22854667)
2012
11
Responses to hepatitis A virus vaccine in HIV-infected women: effect of hormonal contraceptives and HIV disease characteristics. (22517417)
2012
12
The role of immunoglobulin A in prolonged and relapsing hepatitis A virus infections. (22170633)
2012
13
Could oral fluid be used to evaluate anti-hepatitis A virus status in individuals living in difficult-to-access areas? (22910286)
2012
14
Expression of recombinant rotavirus proteins harboring antigenic epitopes of the hepatitis a virus polyprotein in insect cells. (24130930)
2012
15
Hepatitis A. Information from your family doctor. (23198676)
2012
16
A multistate outbreak of hepatitis A associated with semidried tomatoes in Australia, 2009. (22238166)
2012
17
Distribution of copper, iron, and zinc in biological samples (scalp hair, serum, blood, and urine) of Pakistani viral hepatitis (A-E) patients and controls. (20872092)
2011
18
Change in hepatitis A epidemiology after vaccinating high risk children in Taiwan, 1995-2008. (21329774)
2011
19
The Seroconversion Rate of Hepatitis A Virus Vaccination among Patients with Hepatitis B Virus-Related Chronic Liver Disease in Korea. (21814604)
2011
20
Acute hepatitis A virus infection is associated with a limited type I interferon response and persistence of intrahepatic viral RNA. (21690403)
2011
21
Recommendations for administering hepatitis A vaccine to contacts of international adoptees. (21949136)
2011
22
CYP3A4*18 polymorphisms and anti-hepatitis A virus seroprevalence. (21940338)
2011
23
Evaluation of calcium, magnesium, potassium, and sodium in biological samples of Pakistani viral hepatitis (A-E) patients and controls. (21755830)
2011
24
Seroprevalence and correlates of hepatitis a among HIV-negative American men who have sex with men. (21851774)
2011
25
Antibody persistence and immune memory in healthy adults following vaccination with a two-dose inactivated hepatitis A vaccine: long-term follow-up at 15 years. (21915861)
2011
26
Hepatitis A associated with semidried tomatoes, France, 2010. (21392466)
2011
27
MEMS biosensor for detection of Hepatitis A and C viruses in serum. (21803562)
2011
28
Jaundice after radical cholecystectomy and bile duct resection: a case of postoperative acute viral hepatitis a confounding the clinical picture. (22942614)
2011
29
Antioxidant defense and oxidative stress in children with acute hepatitis A. (21623054)
2011
30
Treatment of chronic delta hepatitis: a nine-year retrospective analysis. (22235216)
2011
31
Decline in HAV-associated fulminant hepatic failure and liver transplant in children in Argentina after the introduction of a universal hepatitis A vaccination program. (24367225)
2011
32
Expression of a recombinant chimeric protein of hepatitis A virus VP1-Fc using a replicating vector based on Beet curly top virus in tobacco leaves and its immunogenicity in mice. (21442402)
2011
33
Evaluation of hepatitis A surveillance data and outbreak detection in Yunnan Province, China, from 2004 through 2009. (22299466)
2011
34
Meningoencephalitis associated with hepatitis A infection: a case report and review of literature. (20555050)
2010
35
Nitric oxide levels and sustained virological response to pegylated-interferon alpha2a plus ribavirin in chronic HCV genotype 4 hepatitis: A prospective study. (21188329)
2010
36
Childhood hepatitis A virus infection complicated by pseudotumor cerebri. (19139677)
2009
37
Markers for hepatitis A, B and C in methadone maintained patients: an unexpectedly high co-infection with silent hepatitis B. (18339114)
2008
38
Hepatitis A super infection as a cause of liver failure in a child with Wilson's disease. (17907522)
2007
39
Adenosine deaminase activity in serum of patients with hepatitis -- a useful tool in monitoring clinical status. (17712462)
2007
40
Influence of load of hepatitis A virus on disease severity and its relationship with clinical manifestations in patients with hepatitis A. (16048563)
2005
41
A case of autoimmune hepatitis and autoimmune hemolytic anemia following hepatitis A infection. (14655068)
2003
42
Characteristics of cellular immunity in children with acute viral hepatitis A]. (14708438)
2003
43
An open randomized study of inactivated hepatitis A vaccine administered concomitantly with typhoid fever and yellow fever vaccines. (12044272)
2002
44
Hepatitis A infection mimicking adult onset Still's disease. (10914871)
2000
45
Serious hepatitis A: an analysis of patients hospitalized during an urban epidemic in the United States. (9441570)
1998
46
Licensed preparations against hepatitis A and chickenpox: vaccine update--Part 2. (9051961)
1996
47
Determination of the inactivation kinetics of hepatitis A virus in human plasma products using a simple TCID50 assay. (8732864)
1996
48
Mononeuritis multiplex: a rare complication of acute hepatitis A. (8878003)
1996
49
Do corticosteroids reduce mortality from alcoholic hepatitis? A meta-analysis of the randomized trials. (2142869)
1990
50
Lassa virus hepatitis: a study of fatal Lassa fever in humans. (3953952)
1986

Variations for Hepatitis a

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Expression for genes affiliated with Hepatitis a

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hepatitis a

Search GEO for disease gene expression data for Hepatitis a.

Pathways for genes affiliated with Hepatitis a

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Sources:
50PathCards, 38NCBI BioSystems Database, 30KEGG, 51PharmGKB
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Pathways related to Hepatitis a according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4CD40LG, IGHG3
29.2CD40LG, IGHA1
3
Show member pathways
L-serine degradation38
pentose phosphate pathway (oxidative branch)38
formaldehyde oxidation II (glutathione-dependent)38
9.2G6PD, TPI1, GPT

Compounds for genes affiliated with Hepatitis a

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Sources:
45Novoseek, 51PharmGKB, 11DrugBank, 29IUPHAR, 24HMDB, 3BitterDB, 61Tocris Bioscience
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Compounds related to Hepatitis a according to GeneCards/GeneDecks:

(show top 50)    (show all 64)
idCompoundScoreTop Affiliating Genes
1isoniazid45 51 1112.1G6PD, GPT
2monoethylglycinexylidide4510.1F2, GPT
3hepaplastin4510.1F2, GPT
46-phosphogluconate4510.1G6PD, GPT
5ximelagatran45 1111.1GPT, F2
6aminopyrine4510.1F2, GPT
7alpha-tocopheryl acetate4510.1G6PD, F2
8gemfibrozil29 45 1112.0G6PD, GPT
9sulfamethoxazole51 45 1112.0G6PD, CD40LG
10clarithromycin45 1111.0F2, GPT
11ppack4510.0F2, CD40LG
12tirofiban45 1111.0F2, CD40LG
13lamivudine45 51 1112.0F2, GPT
14fructose-1,6-bisphosphate4510.0G6PD, TPI1
15glutaraldehyde459.9G6PD, CD40LG
16diamide459.9TPI1, G6PD
17sulfasalazine29 45 51 1112.9G6PD, CD40LG
18abciximab45 1110.9F2, CD40LG
19isocitrate459.9TPI1, G6PD
20clopidogrel45 51 24 1112.8CD40LG, F2
21cardiolipin45 1110.8F2, CD40LG
22hirudin459.8CD40LG, F2
23silymarin459.8F2, GPT
24valproate459.8CD40LG, GPT
25ribavirin45 51 1111.8CD40LG, G6PD, GPT
26vitamin b12459.8CD40LG, GPT, G6PD
27Pyridoxal 5'-phosphate249.8G6PD, GPT
28thyroxine45 2410.8CD40LG, GPT, G6PD
29acetaminophen45 3 51 24 1113.7G6PD, F2, GPT
30mycophenolate mofetil45 51 1111.7GPT, CD40LG
31ursodeoxycholic acid45 24 1111.7CD40LG, GPT, F2
32malate459.7TPI1, G6PD, GPT
33hyaluronic acid45 2410.7CD40LG, GPT, F2
34polyethylene glycol459.7CD40LG, F2, G6PD
35alpha tocopherol459.7GPT, G6PD, TPI1
36phosphatidylserine45 29 1111.6G6PD, F2, CD40LG
37pyruvate459.6TPI1, GPT, G6PD
38aspirin45 51 29 2412.6F2, CD40LG, G6PD
39epinephrine45 24 1111.6F2, G6PD, CD40LG
40fibrinogen459.5GPT, CD40LG, F2
41glycerol 3-phosphate45 2410.5G6PD, TPI1
42tamoxifen45 51 29 1112.4F2, G6PD, CTRL
43n acetylcysteine459.3CD40LG, F2, G6PD, GPT
44actinomycin d459.3TPI1, CD40LG, G6PD
45adenylate459.2G6PD, CD40LG, GPT, TPI1
46cyclosporin a45 29 6111.0F2, GPT, CD40LG
47lactate458.8CD40LG, G6PD, TPI1, GPT, F2
48creatinine458.8TPI1, GPT, F2, CD40LG, G6PD
49aspartate458.8F2, GPT, CD40LG, G6PD, TPI1
50serine458.6F2, TPI1, G6PD, CTRL, CD40LG

GO Terms for genes affiliated with Hepatitis a

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16Gene Ontology
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Cellular components related to Hepatitis a according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:0725628.6IGHA1, IGHG3, F2
2extracellular spaceGO:0056156.8CTRL, CD40LG, TPI1, IGHA1, IGHG3, F2

Biological processes related to Hepatitis a according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1pentose-phosphate shuntGO:0060989.3G6PD, TPI1
2retina homeostasisGO:0018959.0IGHA1, IGHG3

Molecular functions related to Hepatitis a according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1antigen bindingGO:0038239.0IGHA1, IGHG3

Products for genes affiliated with Hepatitis a

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hepatitis a

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet