MCID: HPT003
MIFTS: 57

Hepatitis a malady

Infectious, Liver categories

Summaries for Hepatitis a

Sources:
8Disease Ontology, 34MedlinePlus, 64Wikipedia, 33MalaCards
See all sources

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MedlinePlus:34 Your liver is the largest organ inside your body. it helps your body digest food, store energy, and remove poisons. hepatitis is an inflammation of the liver. one type, hepatitis a, is caused by the hepatitis a virus (hav). the disease spreads through contact with an infected person's stool. you can get it from eating food made by an infected person who did not wash their hands after using the bathroom drinking untreated water or eating food washed in untreated water putting into your mouth a finger or object that came into contact with an infected person's stool having close contact with an infected person, such as through sex or caring for someone who is ill most people do not have any symptoms. if you do have symptoms, you may feel as if you have the flu. you may also have yellowish eyes and skin, called jaundice. a blood test will show if you have hav. hav usually gets better in a few weeks without treatment. however, some people can have symptoms for up to 6 months. your doctor may suggest medicines to help relieve your symptoms. the hepatitis a vaccine can prevent hav. good hygiene can also help. wash your hands thoroughly before preparing food, after using the toilet, or after changing a diaper. international travelers should be careful about drinking tap water. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Hepatitis a, also known as viral hepatitis, type a, is related to hepatitis c and hepatitis e, and has symptoms including fever, jaundice and abdominal pain. An important gene associated with Hepatitis a is HAVCR1 (hepatitis A virus cellular receptor 1), and among its related pathways is Carbon metabolism. The compounds lactate and creatinine have been mentioned in the context of this disorder. Affiliated tissues include liver, skin and liver, and related mouse phenotype hematopoietic system.

Disease Ontology:8 A viral infectious disease that results in inflammation located in liver, has material basis in hepatitis a virus, which is transmitted by ingestion of contaminated food or water, or transmitted by direct contact with an infected person. the infection has symptom fever, has symptom fatigue, has symptom loss of appetite, has symptom nausea, has symptom vomiting, has symptom abdominal pain, has symptom clay-colored bowel movements, has symptom joint pain, and has symptom jaundice.

Wikipedia:64 Hepatitis A (formerly known as infectious hepatitis) is an acute infectious disease of the liver caused... more...

Aliases & Classifications for Hepatitis a

Sources:
8Disease Ontology, 10DISEASES, 34MedlinePlus, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious
Anatomical: Liver


Aliases & Descriptions:

hepatitis a 8 10 34 61
viral hepatitis, type a 8


External Ids:

Disease Ontology8 DOID:12549
MeSH35 D006506
SNOMED-CT57 154347003, 40468003
NCIt40 C3096
ICD1025 B15.0, B15.9

Related Diseases for Hepatitis a

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the hepatitis c family:

hepatitis e hepatitis b
autoimmune hepatitis hepatitis d
hepatitis a hepatitis
viral hepatitis hepatitis c virus

Diseases related to Hepatitis a via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 147)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis c31.7IFN1@, CD40LG, F2, GPT
2hepatitis e31.4CD40LG, GPT
3hepatitis b31.2F2, IFN1@, GPT
4viral hepatitis31.1GPT, F2, G6PD, SEPSECS
5autoimmune hepatitis30.9SEPSECS, CD40LG, GPT, F2
6acute liver failure30.3F2, GPT
7acute pancreatitis30.0GPT
8infectious mononucleosis30.0TPI1, CD40LG
9asthma29.6LCN1, HAVCR1, HAVCR2, TBX21
10primary biliary cirrhosis29.6SEPSECS, F2, GPT, CD40LG
11sclerosing cholangitis29.6SEPSECS
12deficiency anemia29.6G6PD, TPI1, F2
13cryoglobulinemia29.6CD40LG
14wilson disease29.6G6PD, GPT
15scrub typhus29.6CD40LG, GPT
16dengue hemorrhagic fever29.6CD40LG
17hepatitis d11.0
18hepatitis c virus10.9
19alcoholic hepatitis10.6
20typhoid fever10.4
21granulomatous hepatitis10.3
22hepatitis b virus infection10.3
23acalculous cholecystitis10.2
24drug-induced hepatitis10.2
25fulminant viral hepatitis10.2
26mumps10.2
27rubella10.1
28measles10.1
29diphtheria10.1
30acute disseminated encephalomyelitis10.1
31autoimmune hemolytic anemia10.1
32tetanus10.1
33myelitis10.0
34renal clear cell carcinoma10.0
35q fever10.0
36celiac disease10.0
37yellow fever10.0
38n syndrome10.0
39thrombocytopenia10.0
40gianotti crosti syndrome10.0
41clear cell renal cell carcinoma10.0
42transverse myelitis10.0
43malaria10.0TPI1, G6PD
44cholelithiasis10.0GPT
45stomach cancer10.0CTRL
46multiple sclerosis10.0TBX21, HAVCR2, IFN1@
47bilirubin metabolic disorder10.0F2, G6PD, GPT
48allergic rhinitis10.0HAVCR1, HAVCR2
49lupus erythematosus10.0CD40LG, F2
50biliary atresia10.0GPT

Graphical network of the top 20 diseases related to Hepatitis a:



Diseases related to hepatitis a

Clinical Features for Hepatitis a

Sources:
8Disease Ontology
See all sources


Symptoms:

8 (show all 9)
  • fever
  • jaundice
  • abdominal pain
  • loss of appetite
  • nausea
  • fatigue
  • vomiting
  • clay-colored bowel movements
  • joint pain

Drugs & Therapeutics for Hepatitis a

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Hepatitis a

Drug clinical trials:

Search ClinicalTrials for Hepatitis a

Search NIH Clinical Center for Hepatitis a

Search CenterWatch for Hepatitis a

Genetic Tests for Hepatitis a

Anatomical Context for Hepatitis a

Sources:
33MalaCards, 14FMA
See all sources

MalaCards organs/tissues related to Hepatitis a:

33
Skin, Liver, Tongue, Spinal cord, Brain, Kidney, Lymph node, Lung, Spleen, Bone marrow, Whole blood, Thymus, Cortex, Heart, Smooth muscle, Skeletal muscle, Small intestine, Colon, Pancreas, Thyroid, Adrenal gland, Breast, Prostate, Myeloid, Monocytes, Nk cells, T cells, B lymphoblasts, B cells, Endothelial, Fetal brain, Parietal lobe, Temporal lobe, Hypothalamus, Fetal liver, Fetal lung, Fetal thyroid, Pancreatic islet, Adrenal cortex, Pituitary

FMA organs/tissues related to Hepatitis a:

14
Liver

Animal Models for Hepatitis a or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Hepatitis a:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539710.5TPI1, F2, CD40LG, TBX21, G6PD, HAVCR2

Publications for Hepatitis a

Sources:
51PubMed
See all sources

Articles related to Hepatitis a:

(show top 50)    (show all 7767)
idTitleAuthorsYear
1
The stability of secreted, acid-labile H77/JFH-1 hepatitis C virus (HCV) particles is altered by patient isolate genotype 1a p7 sequences. (24314642)
2014
2
Identification of the Plasma Metabolomics as Early Diagnostic Markers between Biliary Atresia and Neonatal Hepatitis Syndrome. (24416443)
2014
3
Genome-wide and differential proteomic analysis of hepatitis B virus and aflatoxin b1 related hepatocellular carcinoma in guangxi, china. (24391771)
2013
4
Impact of sustained virus elimination on natural anticoagulant activity in patients with chronic viral hepatitis C. (23725503)
2013
5
Epidemiology of hepatitis C virus infection and risk factor analysis in the Hebei Province, China. (24069430)
2013
6
Determinants of the clinical outcome of patients with severe acute exacerbation of chronic hepatitis B virus infection. (22370817)
2012
7
Comment to "Unusual evolution of ciprofloxacin-induced hepatitis revealing a possible link with IgG4-associated autoimmune hepatitis". (22480968)
2012
8
Hepatitis C virus infection in alcoholic hepatitis: prevalence patterns and impact on in-hospital mortality. (22735607)
2012
9
Role of myeloid-derived suppressor cells in amelioration of experimental autoimmune hepatitis following activation of TRPV1 receptors by cannabidiol. (21483776)
2011
10
Autoimmune hepatitis-like disease in C57BL/6 mice infected with mouse hepatitis virus A59. (21635973)
2011
11
Hepatitis B surface antigen confirmatory testing for diagnosis of hepatitis B virus infection in Taiwan. (21739440)
2011
12
Serum aminotransferase levels instead of etiology affects the accuracy of transient elastography in chronic viral hepatitis patients. (21332545)
2011
13
Epitope spreading of the anti-CYP2D6 antibody response in patients with autoimmune hepatitis and in the CYP2D6 mouse model. (21795021)
2011
14
Altered cytokine levels and increased CD4+CD57+ T cells in the peripheral blood of hepatitis C virus-related hepatocellular carcinoma patients. (21491089)
2011
15
Unusual evolution of ciprofloxacin-induced hepatitis revealing a possible link with IgG4-associated autoimmune hepatitis. (21752734)
2011
16
Emerging risk for viral hepatitis A in Croatian adults. (21258315)
2010
17
Human SepSecS or SLA/LP: selenocysteine formation and autoimmune hepatitis. (20623998)
2010
18
Evolution and predictive factors of thyroid disorder due to interferon alpha in the treatment of hepatitis C. (19140232)
2009
19
Impact of interferon alpha immunotherapy on tryptophan metabolism in patients with chronic hepatitis C. Results of a pilot studies on ten patients]. (19853722)
2009
20
A pharmacogenetic study of polymorphisms in interferon pathway genes and response to interferon-alpha treatment in chronic hepatitis B patients. (19559055)
2009
21
Branched-chain amino acids improve insulin resistance in patients with hepatitis C virus-related liver disease: report of two cases. (17919242)
2007
22
Recurrence of autoimmune hepatitis after liver transplantation without elevation of alanine aminotransferase. (17461459)
2007
23
Evolution of hepatitis C virus quasispecies during ribavirin and interferon-alpha-2b combination therapy and interferon-alpha-2b monotherapy. (16926548)
2006
24
T1653 mutation in the box alpha increases the risk of hepatocellular carcinoma in patients with chronic hepatitis B virus genotype C infection. (16323084)
2006
25
Specific ssDNA concentration in liver tissue as an index of apoptosis in hepatitis C virus-infected patients. (16273639)
2005
26
Effect of cytokine genotypes on the hepatitis B virus-hepatocellular carcinoma association. (15643599)
2005
27
Control of antiviral defenses through hepatitis C virus disruption of retinoic acid-inducible gene-I signaling. (15710892)
2005
28
Lamivudine for the treatment of hepatitis B virus-related liver disease after renal transplantation: meta-analysis of clinical trials. (15077027)
2004
29
Early treatment of acute hepatitis C with interferon alpha-2b or interferon alpha-2b plus ribavirin: study of sixteen patients]. (12700516)
2003
30
Chronic phase lipids in sera of chronic fatigue syndrome (CFS), chronic ciguatera fish poisoning (CCFP), hepatitis B, and cancer with antigenic epitope resembling ciguatoxin, as assessed with MAb-CTX. (12784262)
2003
31
Perfluorocarbonic compounds application as a new approach in pathogenic treatment of severe forms of viral hepatitis]. (12856570)
2003
32
Concentrations of cytokines, soluble interleukin-2 receptor, and soluble CD30 in sera of patients with hepatitis B virus infection during acute and convalescent phases. (12414777)
2002
33
Diffuse hypertrichosis in the course of hepatitis C treatment by IFN-alpha and ribavirin. (12396727)
2002
34
Additional interferon alpha for lamivudine resistant hepatitis B infection after liver transplantation: a preliminary report. (10836394)
2000
35
Decorin and actin expression and distribution in patients with chronic hepatitis C following interferon-alfa-2b treatment. (10898320)
2000
36
Hepatitis B virus-related insertional mutagenesis implicates SERCA1 gene in the control of apoptosis. (10871838)
2000
37
Zadaxin (thymosin alpha1) for the treatment of viral hepatitis. (15992078)
1999
38
Phosphatidylinositol 3-kinase is required for the regulation of hepatitis B surface antigen production and mitogen-activated protein kinase activation by insulin but not by TPA. (9600088)
1998
39
A multicentre randomized controlled trial of recombinant interferon-alpha-2a in the treatment of patients with chronic hepatitis C. (9395758)
1997
40
Cytolytic hepatitis during treatment with phenothiazines: apropos of a case]. (9035996)
1996
41
Hepatic Fas antigen expression before and after interferon therapy in patients with chronic hepatitis C. (9011457)
1996
42
Serum hyaluronate in patients with acute and fulminant hepatitis. (8680544)
1996
43
Differential pathways of insulin action upon the hepatitis B surface antigen gene expression and cell proliferation in human hepatoma cells. (7789317)
1995
44
Can chronic hepatitis B patients overcome resistance to antiviral therapy due to production of antibodies to recombinant alpha-2-interferon?]. (7716906)
1994
45
Recent advances in clinical aspects of infectious hepatitis]. (8485763)
1993
46
Assay of serum interleukin 8 levels in patients with alcoholic hepatitis. (7908198)
1993
47
Functional analysis of peripheral blood lymphocytes isolated from patients with chronic hepatitis type B. (1728533)
1992
48
Decrease in reported posttransfusion hepatitis. Contributions of donor screening for alanine aminotransferase and antibodies to hepatitis B core antigen and changes in the general population. (1747001)
1991
49
Differential diagnosis of acute viral hepatitis using rapid, fully automated immunoassays. (1880494)
1991
50
Proliferative glomerulonephritis and chronic active hepatitis with cirrhosis associated with Corynebacterium parvum immunotherapy in a dog. (3818425)
1987

Genetic Variations for Hepatitis a

Expression for genes affiliated with Hepatitis a

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Hepatitis a

Search GEO for disease gene expression data for Hepatitis a.

Pathways for genes affiliated with Hepatitis a

Sources:
30KEGG
See all sources

Pathways related to Hepatitis a according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.5TPI1, GPT, G6PD

Compounds for genes affiliated with Hepatitis a

Sources:
45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB, 2BitterDB
See all sources

Compounds related to Hepatitis a according to GeneCards/GeneDecks:

(show all 25)
idCompoundScoreTop Affiliating Genes
1lactate4510.8TPI1, F2, GPT, CD40LG, G6PD, LCN1
2creatinine4510.8LCN1, G6PD, CD40LG, GPT, F2, TPI1
3aspartate4510.8LCN1, G6PD, CD40LG, GPT, F2, TPI1
4ursodeoxycholic acid45 11 2412.8F2, GPT, CD40LG
5hyaluronic acid45 2411.8F2, GPT, CD40LG, LCN1
6mycophenolate mofetil45 50 1112.8CD40LG, GPT, SEPSECS
7p-cbp4510.8PCBP1, PCBP2
8alpha-tocopheryl acetate4510.8F2, G6PD
9ribavirin45 50 1112.8GPT, CD40LG, G6PD
10malate4510.8G6PD, GPT, TPI1
11ivig4510.8CD40LG, GPT, SEPSECS
12monoethylglycinexylidide4510.8GPT
13hepaplastin4510.8GPT, F2
14vitamin b124510.7GPT, CD40LG, G6PD
15ximelagatran45 1111.7GPT, F2
16acetaminophen45 2 50 11 2414.7F2, GPT, G6PD
17n acetylcysteine4510.7F2, GPT, CD40LG, G6PD
18uric acid45 2411.6LCN1, G6PD
19polyethylene glycol4510.6F2, CD40LG, G6PD
20aminopyrine4510.6F2, GPT
21ppack4510.5F2, CD40LG
22tirofiban45 1111.5F2, CD40LG
23poly c4510.5PCBP1, PCBP2
24alpha tocopherol4510.4TPI1, GPT, G6PD
25fructose-1,6-bisphosphate4510.2TPI1, G6PD

GO Terms for genes affiliated with Hepatitis a

Sources:
16Gene Ontology
See all sources

Biological processes related to Hepatitis a according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1pentose-phosphate shuntGO:00609810.5TPI1, G6PD

Products for genes affiliated with Hepatitis a

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hepatitis a

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet