MCID: HPT003
MIFTS: 50

Hepatitis a malady

Genetic diseases, Infectious diseases, Liver diseases, Gastrointestinal diseases, Rare diseases categories

Summaries for Hepatitis a

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MedlinePlus:32 Your liver is the largest organ inside your body. it helps your body digest food, store energy, and remove poisons. hepatitis is an inflammation of the liver. one type, hepatitis a, is caused by the hepatitis a virus (hav). the disease spreads through contact with an infected person's stool. you can get it from eating food made by an infected person who did not wash their hands after using the bathroom drinking untreated water or eating food washed in untreated water putting into your mouth a finger or object that came into contact with an infected person's stool having close contact with an infected person, such as through sex or caring for someone who is ill most people do not have any symptoms. if you do have symptoms, you may feel as if you have the flu. you may also have yellowish eyes and skin, called jaundice. a blood test will show if you have hav. hav usually gets better in a few weeks without treatment. however, some people can have symptoms for up to 6 months. your doctor may suggest medicines to help relieve your symptoms. the hepatitis a vaccine can prevent hav. good hygiene can also help. wash your hands thoroughly before preparing food, after using the toilet, or after changing a diaper. international travelers should be careful about drinking tap water. nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary: Hepatitis a, also known as viral hepatitis, type a, is related to hepatitis and alcoholic hepatitis, and has symptoms including fever, fatigue and loss of appetite. An important gene associated with Hepatitis a is HAVCR1 (hepatitis A virus cellular receptor 1), and among its related pathways are IL4-mediated signaling events and Inflammatory Response Pathway. The compounds isoniazid and monoethylglycinexylidide have been mentioned in the context of this disorder. Affiliated tissues include liver, liver and skin, and related mouse phenotype hematopoietic system.

Disease Ontology:9 A viral infectious disease that results in inflammation located in liver, has material basis in hepatitis a virus, which is transmitted by ingestion of contaminated food or water, or transmitted by direct contact with an infected person. the infection has symptom fever, has symptom fatigue, has symptom loss of appetite, has symptom nausea, has symptom vomiting, has symptom abdominal pain, has symptom clay-colored bowel movements, has symptom joint pain, and has symptom jaundice.

Wikipedia:63 Hepatitis A (formerly known as infectious hepatitis) is an acute infectious disease of the liver caused... more...

Aliases & Classifications for Hepatitis a

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Hepatitis a, Aliases & Descriptions:

Name: Hepatitis a 9 11 32 60
 
Viral Hepatitis, Type a 9


Classifications:



External Ids:

Disease Ontology9 DOID:12549
MeSH33 D006506
SNOMED-CT55 40468003, 154347003
NCIt38 C3096
ICD1025 B15.0, B15.9

Related Diseases for Hepatitis a

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Diseases in the Hepatitis family:

Hepatitis C Virus Autoimmune Hepatitis
Hepatitis B Hepatitis C
Hepatitis D hepatitis a
Hepatitis E Viral Hepatitis

Diseases related to Hepatitis a via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 177)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis32.1F2, GPT
2alcoholic hepatitis31.4GPT, F2
3viral hepatitis31.3G6PD, GPT, F2
4autoimmune hepatitis31.1CD40LG, GPT, F2
5cholecystitis31.1GPT
6hepatitis e31.0GPT, CD40LG
7hepatitis b31.0GPT, F2
8acute liver failure30.8F2, GPT
9hepatitis c30.7CD40LG, GPT, F2
10autoimmune hemolytic anemia30.7G6PD, CD40LG
11malaria30.5TPI1, G6PD
12hemolytic anemia30.5G6PD, TPI1
13hemorrhagic fever30.4CD40LG
14cholestasis30.4GPT, F2
15plasmodium falciparum malaria30.2G6PD, TPI1
16thrombocytopenia30.2CD40LG, GPT, F2
17scrub typhus30.2GPT, CD40LG
18vasculitis30.1CD40LG, F2
19galactosemia30.0F2, GPT
20primary biliary cirrhosis29.9F2, GPT, CD40LG
21lupus erythematosus29.8CD40LG, F2
22choledocholithiasis10.5GPT
23mediterranean spotted fever10.5G6PD
24typhoid fever10.4
25granulomatous hepatitis10.4
26wilson disease10.3G6PD, GPT
27hepatitis c virus10.3
28portal hypertension10.3GPT, F2
29hepatic encephalopathy10.3GPT, F2
30acute kidney failure10.3GPT, G6PD
31blood protein disease10.3F2, CD40LG
32alcoholic liver cirrhosis10.3F2, GPT
33congenital hemolytic anemia10.3G6PD, TPI1
34acalculous cholecystitis10.3
35bilirubin metabolic disorder10.2G6PD, F2
36pfeiffer syndrome10.2TPI1, CD40LG
37blindness10.2
38fulminant viral hepatitis10.2
39pregnancy loss, recurrent 110.2CD40LG, F2
40antiphospholipid syndrome10.2CD40LG, F2
41thrombophilia due to thrombin defect10.2F2, G6PD
42leukopenia10.2F2, GPT
43pure red-cell aplasia10.2
44mumps10.2
45influenza10.2
46liver disease10.2
47rubella10.2
48measles10.2
49glucose-6-phosphate dehydrogenase deficiency10.2
50purpura10.2

Graphical network of the top 20 diseases related to Hepatitis a:



Diseases related to hepatitis a

Symptoms for Hepatitis a

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Symptoms:

 9 (show all 9)
  • fever
  • fatigue
  • loss of appetite
  • nausea
  • vomiting
  • abdominal pain
  • clay-colored bowel movements
  • joint pain
  • jaundice

Drugs & Therapeutics for Hepatitis a

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Drug clinical trials:

Search ClinicalTrials for Hepatitis a

Search NIH Clinical Center for Hepatitis a

Genetic Tests for Hepatitis a

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Anatomical Context for Hepatitis a

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MalaCards organs/tissues related to Hepatitis a:

31
Liver, Skin, Testes, Kidney, Eye, T cells, Thyroid, Heart, Pancreas, B cells, Endothelial

FMA organs/tissues related to Hepatitis a:

14
Liver

Animal Models for Hepatitis a or affiliated genes

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MGI Mouse Phenotypes related to Hepatitis a:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.4CD40LG, G6PD, TPI1, HAVCR1, F2

Publications for Hepatitis a

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Articles related to Hepatitis a:

(show top 50)    (show all 799)
idTitleAuthorsYear
1
Letter to the Editor in Response to the Editorial Commentary by Dr Kenrad E. Nelson Entitled, "The Changing Epidemiology of Hepatitis A Virus Infections in the United States". (25784730)
2015
2
Hepatitis A Virus Genotype Distribution during a Decade of Universal Vaccination of Preadolescents. (25815599)
2015
3
Pure red-cell aplasia and autoimmune hemolytic anemia in a patient with acute hepatitis A. (25032187)
2014
4
A case of acute motor and sensory axonal neuropathy following hepatitis a infection. (24339719)
2013
5
Isolation and characterization of a low pathogenic duck hepatitis A virus 3 from South Korea. (23265242)
2013
6
Pseudothrombocytopenia or platelet clumping as a possible cause of low platelet count in patients with viral infection: a case series from single institution focusing on hepatitis A virus infection. (22958573)
2013
7
Seroprevalence of anti-hepatitis a antibody among 1 - 15 year old children in kashan-iran. (23967019)
2013
8
Survival of murine norovirus, Tulane virus, and hepatitis A virus on alfalfa seeds and sprouts during storage and germination. (24014537)
2013
9
Oral fluid and hepatitis A, B and C: a literature review. (22188507)
2012
10
Randomized trial: immunogenicity and safety of coadministered human papillomavirus-16/18 AS04-adjuvanted vaccine and combined hepatitis A and B vaccine in girls. (22188832)
2012
11
A case of severe acute hepatitis a complicated with pure red cell aplasia. (23018540)
2012
12
The depuration dynamics of oysters (Crassostrea gigas) artificially contaminated with hepatitis A virus and human adenovirus. (22310530)
2012
13
Model-based projections of the population-level impact of hepatitis A vaccination in Mexico. (22854667)
2012
14
Responses to hepatitis A virus vaccine in HIV-infected women: effect of hormonal contraceptives and HIV disease characteristics. (22517417)
2012
15
The role of immunoglobulin A in prolonged and relapsing hepatitis A virus infections. (22170633)
2012
16
Could oral fluid be used to evaluate anti-hepatitis A virus status in individuals living in difficult-to-access areas? (22910286)
2012
17
Expression of recombinant rotavirus proteins harboring antigenic epitopes of the hepatitis a virus polyprotein in insect cells. (24130930)
2012
18
Hepatitis A. Information from your family doctor. (23198676)
2012
19
Distribution of copper, iron, and zinc in biological samples (scalp hair, serum, blood, and urine) of Pakistani viral hepatitis (A-E) patients and controls. (20872092)
2011
20
Change in hepatitis A epidemiology after vaccinating high risk children in Taiwan, 1995-2008. (21329774)
2011
21
The Seroconversion Rate of Hepatitis A Virus Vaccination among Patients with Hepatitis B Virus-Related Chronic Liver Disease in Korea. (21814604)
2011
22
Acute hepatitis A virus infection is associated with a limited type I interferon response and persistence of intrahepatic viral RNA. (21690403)
2011
23
Recommendations for administering hepatitis A vaccine to contacts of international adoptees. (21949136)
2011
24
CYP3A4*18 polymorphisms and anti-hepatitis A virus seroprevalence. (21940338)
2011
25
Evaluation of calcium, magnesium, potassium, and sodium in biological samples of Pakistani viral hepatitis (A-E) patients and controls. (21755830)
2011
26
Seroprevalence and correlates of hepatitis a among HIV-negative American men who have sex with men. (21851774)
2011
27
Antibody persistence and immune memory in healthy adults following vaccination with a two-dose inactivated hepatitis A vaccine: long-term follow-up at 15 years. (21915861)
2011
28
Hepatitis A associated with semidried tomatoes, France, 2010. (21392466)
2011
29
MEMS biosensor for detection of Hepatitis A and C viruses in serum. (21803562)
2011
30
Jaundice after radical cholecystectomy and bile duct resection: a case of postoperative acute viral hepatitis a confounding the clinical picture. (22942614)
2011
31
Antioxidant defense and oxidative stress in children with acute hepatitis A. (21623054)
2011
32
Decline in HAV-associated fulminant hepatic failure and liver transplant in children in Argentina after the introduction of a universal hepatitis A vaccination program. (24367225)
2011
33
Expression of a recombinant chimeric protein of hepatitis A virus VP1-Fc using a replicating vector based on Beet curly top virus in tobacco leaves and its immunogenicity in mice. (21442402)
2011
34
Meningoencephalitis associated with hepatitis A infection: a case report and review of literature. (20555050)
2010
35
Nitric oxide levels and sustained virological response to pegylated-interferon alpha2a plus ribavirin in chronic HCV genotype 4 hepatitis: A prospective study. (21188329)
2010
36
Childhood hepatitis A virus infection complicated by pseudotumor cerebri. (19139677)
2009
37
Markers for hepatitis A, B and C in methadone maintained patients: an unexpectedly high co-infection with silent hepatitis B. (18339114)
2008
38
Hepatitis A super infection as a cause of liver failure in a child with Wilson's disease. (17907522)
2007
39
Adenosine deaminase activity in serum of patients with hepatitis -- a useful tool in monitoring clinical status. (17712462)
2007
40
Influence of load of hepatitis A virus on disease severity and its relationship with clinical manifestations in patients with hepatitis A. (16048563)
2005
41
A case of autoimmune hepatitis and autoimmune hemolytic anemia following hepatitis A infection. (14655068)
2003
42
Characteristics of cellular immunity in children with acute viral hepatitis A]. (14708438)
2003
43
An open randomized study of inactivated hepatitis A vaccine administered concomitantly with typhoid fever and yellow fever vaccines. (12044272)
2002
44
Hepatitis A infection mimicking adult onset Still's disease. (10914871)
2000
45
Serious hepatitis A: an analysis of patients hospitalized during an urban epidemic in the United States. (9441570)
1998
46
Licensed preparations against hepatitis A and chickenpox: vaccine update--Part 2. (9051961)
1996
47
Determination of the inactivation kinetics of hepatitis A virus in human plasma products using a simple TCID50 assay. (8732864)
1996
48
Mononeuritis multiplex: a rare complication of acute hepatitis A. (8878003)
1996
49
Do corticosteroids reduce mortality from alcoholic hepatitis? A meta-analysis of the randomized trials. (2142869)
1990
50
Lassa virus hepatitis: a study of fatal Lassa fever in humans. (3953952)
1986

Variations for Hepatitis a

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Expression for genes affiliated with Hepatitis a

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Search GEO for disease gene expression data for Hepatitis a.

Pathways for genes affiliated with Hepatitis a

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Pathways related to Hepatitis a according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4CD40LG, IGHG3
29.2CD40LG, IGHA1
3
Show member pathways
L-serine degradation36
pentose phosphate pathway (oxidative branch)36
formaldehyde oxidation II (glutathione-dependent)36
9.2G6PD, TPI1, GPT

Compounds for genes affiliated with Hepatitis a

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Compounds related to Hepatitis a according to GeneCards Suite gene sharing:

(show top 50)    (show all 64)
idCompoundScoreTop Affiliating Genes
1isoniazid43 49 1212.1G6PD, GPT
2monoethylglycinexylidide4310.1F2, GPT
3hepaplastin4310.1F2, GPT
46-phosphogluconate4310.1G6PD, GPT
5ximelagatran43 1211.1GPT, F2
6aminopyrine4310.1GPT, F2
7alpha-tocopheryl acetate4310.1G6PD, F2
8gemfibrozil28 43 1212.0GPT, G6PD
9sulfamethoxazole49 43 1212.0CD40LG, G6PD
10clarithromycin43 1211.0F2, GPT
11ppack4310.0CD40LG, F2
12tirofiban43 1211.0CD40LG, F2
13lamivudine43 49 1212.0F2, GPT
14fructose-1,6-bisphosphate4310.0G6PD, TPI1
15glutaraldehyde439.9G6PD, CD40LG
16diamide439.9TPI1, G6PD
17sulfasalazine28 43 49 1212.9CD40LG, G6PD
18abciximab43 1210.9CD40LG, F2
19isocitrate439.9G6PD, TPI1
20clopidogrel43 49 24 1212.8CD40LG, F2
21cardiolipin43 1210.8CD40LG, F2
22hirudin439.8F2, CD40LG
23silymarin439.8GPT, F2
24valproate439.8CD40LG, GPT
25ribavirin43 49 1211.8CD40LG, G6PD, GPT
26vitamin b12439.8CD40LG, G6PD, GPT
27Pyridoxal 5'-phosphate249.8G6PD, GPT
28thyroxine43 2410.8CD40LG, G6PD, GPT
29acetaminophen43 2 49 24 1213.7F2, GPT, G6PD
30mycophenolate mofetil43 49 1211.7GPT, CD40LG
31ursodeoxycholic acid43 24 1211.7F2, GPT, CD40LG
32malate439.7GPT, TPI1, G6PD
33hyaluronic acid43 2410.7F2, GPT, CD40LG
34polyethylene glycol439.7CD40LG, G6PD, F2
35alpha tocopherol439.7G6PD, TPI1, GPT
36phosphatidylserine43 28 1211.6F2, G6PD, CD40LG
37pyruvate439.6G6PD, TPI1, GPT
38aspirin43 49 28 2412.6CD40LG, G6PD, F2
39epinephrine43 24 1211.6F2, G6PD, CD40LG
40fibrinogen439.5CD40LG, GPT, F2
41glycerol 3-phosphate43 2410.5G6PD, TPI1
42tamoxifen43 49 28 1212.4CTRL, G6PD, F2
43n acetylcysteine439.3CD40LG, G6PD, GPT, F2
44actinomycin d439.3CD40LG, G6PD, TPI1
45adenylate439.2GPT, TPI1, G6PD, CD40LG
46cyclosporin a43 28 5911.0CD40LG, GPT, F2
47lactate438.8CD40LG, G6PD, TPI1, GPT, F2
48creatinine438.8F2, GPT, TPI1, G6PD, CD40LG
49aspartate438.8CD40LG, G6PD, TPI1, GPT, F2
50serine438.6F2, TPI1, G6PD, CD40LG, CTRL

GO Terms for genes affiliated with Hepatitis a

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Cellular components related to Hepatitis a according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:00725628.6IGHA1, IGHG3, F2
2extracellular spaceGO:00056156.8CTRL, CD40LG, TPI1, IGHA1, IGHG3, F2

Biological processes related to Hepatitis a according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1pentose-phosphate shuntGO:00060989.3G6PD, TPI1
2retina homeostasisGO:00018959.0IGHA1, IGHG3

Molecular functions related to Hepatitis a according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1antigen bindingGO:00038239.0IGHA1, IGHG3

Products for genes affiliated with Hepatitis a

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Hepatitis a

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet