MCID: HPT003
MIFTS: 60

Hepatitis a malady

Infectious diseases, Liver diseases categories

Summaries for Hepatitis a

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Sources:
8Disease Ontology, 33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Your liver is the largest organ inside your body. it helps your body digest food, store energy, and remove poisons. hepatitis is an inflammation of the liver. one type, hepatitis a, is caused by the hepatitis a virus (hav). the disease spreads through contact with an infected person's stool. you can get it from eating food made by an infected person who did not wash their hands after using the bathroom drinking untreated water or eating food washed in untreated water putting into your mouth a finger or object that came into contact with an infected person's stool having close contact with an infected person, such as through sex or caring for someone who is ill most people do not have any symptoms. if you do have symptoms, you may feel as if you have the flu. you may also have yellowish eyes and skin, called jaundice. a blood test will show if you have hav. hav usually gets better in a few weeks without treatment. however, some people can have symptoms for up to 6 months. your doctor may suggest medicines to help relieve your symptoms. the hepatitis a vaccine can prevent hav. good hygiene can also help. wash your hands thoroughly before preparing food, after using the toilet, or after changing a diaper. international travelers should be careful about drinking tap water. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Hepatitis a, also known as viral hepatitis, type a, is related to hepatitis and viral hepatitis, and has symptoms including fever, clay-colored bowel movements and fatigue. An important gene associated with Hepatitis a is HAVCR1 (hepatitis A virus cellular receptor 1), and among its related pathways is Carbon metabolism. The compounds lactate and creatinine have been mentioned in the context of this disorder. Affiliated tissues include liver, liver and kidney, and related mouse phenotype hematopoietic system.

Disease Ontology:8 A viral infectious disease that results in inflammation located in liver, has material basis in hepatitis a virus, which is transmitted by ingestion of contaminated food or water, or transmitted by direct contact with an infected person. the infection has symptom fever, has symptom fatigue, has symptom loss of appetite, has symptom nausea, has symptom vomiting, has symptom abdominal pain, has symptom clay-colored bowel movements, has symptom joint pain, and has symptom jaundice.

Wikipedia:63 Hepatitis A (formerly known as infectious hepatitis) is an acute infectious disease of the liver caused... more...

Aliases & Classifications for Hepatitis a

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Sources:
8Disease Ontology, 10DISEASES, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Liver diseases


Aliases & Descriptions:

hepatitis a 8 10 33 60
viral hepatitis, type a 8


External Ids:

Disease Ontology8 DOID:12549
MeSH34 D006506
SNOMED-CT56 154347003, 40468003
NCIt39 C3096
ICD1025 B15.0, B15.9

Related Diseases for Hepatitis a

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Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Hepatitis C family:

Hepatitis E Hepatitis B
Autoimmune Hepatitis Hepatitis D
hepatitis a Hepatitis
Viral Hepatitis Hepatitis C Virus

Diseases related to Hepatitis a via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 161)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis31.8GPT, F2, SEPSECS
2viral hepatitis31.1GPT, F2, G6PD, SEPSECS
3hepatitis b31.0F2, IFN1@, GPT
4autoimmune hepatitis30.9SEPSECS, CD40LG, GPT, F2
5hepatitis c30.8IFN1@, CD40LG, F2, GPT
6hepatitis e30.8CD40LG, GPT
7cholecystitis30.3GPT
8acute liver failure30.3F2, GPT
9cholestasis30.2GPT, F2
10malaria30.1TPI1, G6PD
11encephalomyelitis30.1HAVCR2, IFN1@
12acute pancreatitis30.0GPT
13infectious mononucleosis30.0TPI1, CD40LG
14asthma29.6LCN1, HAVCR1, HAVCR2, TBX21
15lupus erythematosus29.6CD40LG, F2
16primary biliary cirrhosis29.6SEPSECS, F2, GPT, CD40LG
17sclerosing cholangitis29.6SEPSECS
18rheumatoid arthritis29.6HAVCR1, CD40LG
19cholangitis29.6GPT, SEPSECS
20deficiency anemia29.6G6PD, TPI1, F2
21galactosemia29.6GPT, SEPSECS, G6PD, F2
22scrub typhus29.6CD40LG, GPT
23dengue hemorrhagic fever29.6CD40LG
24alcoholic hepatitis10.6
25typhoid fever10.4
26granulomatous hepatitis10.3
27acalculous cholecystitis10.2
28drug-induced hepatitis10.2
29mumps10.2
30influenza10.2
31rubella10.1
32pure red-cell aplasia10.1
33measles10.1
34liver disease10.1
35purpura10.1
36diphtheria10.1
37acute disseminated encephalomyelitis10.1
38autoimmune hemolytic anemia10.1
39hepatitis d10.1
40hemolytic anemia10.1
41hepatocellular carcinoma10.1
42tetanus10.1
43myelitis10.0
44renal clear cell carcinoma10.0
45cerebritis10.0
46celiac disease10.0
47yellow fever10.0
48encephalitis10.0
49inflammatory bowel disease10.0
50pancreatitis10.0

Graphical network of the top 20 diseases related to Hepatitis a:



Diseases related to hepatitis a

Clinical Features for Hepatitis a

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Sources:
8Disease Ontology
See all sources


Symptoms:

8 (show all 9)
  • fever
  • clay-colored bowel movements
  • fatigue
  • loss of appetite
  • jaundice
  • joint pain
  • abdominal pain
  • nausea
  • vomiting

Drugs & Therapeutics for Hepatitis a

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Hepatitis a

Drug clinical trials:

Search ClinicalTrials for Hepatitis a

Search NIH Clinical Center for Hepatitis a

Search CenterWatch for Hepatitis a

Genetic Tests for Hepatitis a

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Anatomical Context for Hepatitis a

About this section
Sources:
32MalaCards, 14FMA
See all sources

MalaCards organs/tissues related to Hepatitis a:

32
Liver, Kidney, Testes, Skin, T cells, Thyroid, Brain, Eye, B cells, Bone, Bone marrow, Endothelial, Lung, Colon, Heart, Pancreas, Monocytes, Nk cells, Myeloid, Breast, Tongue, Prostate, Spinal cord, Lymph node, Smooth muscle, Ovary, Adipocyte, Salivary gland, Cortex, Testis, Prefrontal cortex, Cingulate cortex, Thalamus, Fetal liver, Spleen, Placenta, Pituitary, Skeletal muscle, Small intestine, Whole blood

FMA organs/tissues related to Hepatitis a:

14
Liver

Animal Models for Hepatitis a or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Hepatitis a:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539710.5TPI1, F2, CD40LG, TBX21, G6PD, HAVCR2

Publications for Hepatitis a

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Sources:
50PubMed
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Articles related to Hepatitis a:

(show top 50)    (show all 5560)
idTitleAuthorsYear
1
Autoimmune hepatitis: A noninfectious killer. (24170733)
2014
2
Hepatitis B reactivation following treatment with abatacept in a patient with past hepatitis B virus infection. (23771951)
2014
3
The communication of a secondary care diagnosis of autoimmune hepatitis to primary care practitioners: a population-based study. (23635009)
2013
4
Molecular characterization of a novel hepatitis E virus (HEV) strain obtained from a wild boar in Japan that is highly divergent from the previously recognized HEV strains. (24370869)
2013
5
Maturity-onset diabetes of the young and hepatic adenomatosis - characterisation of a new mutation. (23616187)
2013
6
Hepatitis B virus reactivation in a juvenile rheumatoid arthritis patient under treatment and its successful management: a complicated case. (22147111)
2013
7
Serum ceruloplasmin levels correlate negatively with liver fibrosis in males with chronic hepatitis B: a new noninvasive model for predicting liver fibrosis in HBV-related liver disease. (24282481)
2013
8
Hepatitis E virus infection as a new probable cause of de novo membranous nephropathy after kidney transplantation. (24103101)
2013
9
MicroRNA-29a-5p is a novel predictor for early recurrence of hepatitis B virus-related hepatocellular carcinoma after surgical resection. (23285022)
2012
10
Association of IL-10, IL-4, and IL-28B gene polymorphisms with spontaneous clearance of hepatitis C virus in a population from Rio de Janeiro. (22986179)
2012
11
Selection pressure on the hepatitis B virus pre-S/S and P open reading frames in Tongan subjects with a chronic hepatitis B virus infection. (22960602)
2012
12
Low prevalence of hepatitis A virus infection among autochthonous populations of New World non-human primates. (21967448)
2012
13
Morbidity and mortality related to non-hepatic surgery in patients with liver cirrhosis: a systematic review. (22482525)
2012
14
Intrarenal resistance index as a prognostic parameter in patients with liver cirrhosis compared with other hepatic scoring systems. (23207318)
2012
15
Peptidyl-prolyl isomerase Pin1 is a cellular factor required for hepatitis C virus propagation. (21680504)
2011
16
A genome-wide association study of hepatitis B vaccine response in an Indonesian population reveals multiple independent risk variants in the HLA region. (21764829)
2011
17
Hepatic alveolar echinococcosis: a diagnostic challenge. (21466058)
2011
18
The relationship between tumor necrosis factor-I+ polymorphisms and hepatitis C virus infection: a systematic review and meta-analysis. (21851198)
2011
19
Hepatitis B virus X protein enhances cisplatin-induced hepatotoxicity via a mechanism involving degradation of Mcl-1. (21228225)
2011
20
Seroprevalence rates of Helicobacter pylori and viral hepatitis A among adolescents in three regions of the Kingdom of Saudi Arabia: is there any correlation? (21073610)
2010
21
Hepatic angiomyolipoma: a case report. (20518257)
2010
22
Solitary orbital plasmacytoma associated with chronic hepatitis C: a case report. (19229750)
2009
23
Transient autoimmune hepatitis induced by a thymoma. (19352338)
2009
24
Wnt-1 protein as a prognostic biomarker for hepatitis B-related and hepatitis C-related hepatocellular carcinoma after surgery. (19423534)
2009
25
Demographics of a large cohort of urban chronic hepatitis C patients. (19669268)
2008
26
Scarlet Fever and hepatitis: a case report. (18923666)
2008
27
Serum apoptotic caspase activity as a marker of severity in HBeAg-negative chronic hepatitis B virus infection. (18025069)
2008
28
A peroxisome-proliferator activated receptor-gamma ligand could regulate the expression of leptin receptor on human hepatic stellate cells. (17393179)
2007
29
Human serum amyloid A protein inhibits hepatitis C virus entry into cells. (17329325)
2007
30
A predictive index for the diagnosis of cirrhosis in hepatitis C based on clinical, laboratory, and ultrasound findings. (16357620)
2006
31
A virological response study of serum leptin level and insulin resistance on the antivirus effect in patients with chronic hepatitis C]. (17196129)
2006
32
A karyopherin alpha2 nuclear transport pathway is regulated by glucose in hepatic and pancreatic cells. (14675421)
2004
33
Role of human hepatic cytochrome P-450s in territrem A metabolism. (12851121)
2003
34
Binding of the hepatitis C virus E2 glycoprotein to CD81 is strain specific and is modulated by a complex interplay between hypervariable regions 1 and 2. (12525620)
2003
35
Non-alcoholic fatty liver syndrome: a hepatic consequence of common metabolic diseases. (12702052)
2003
36
Characterization of a stellate cell activation-associated protein (STAP) with peroxidase activity found in rat hepatic stellate cells. (11320098)
2001
37
Antiproliferative properties of sphingosine 1-phosphate in human hepatic myofibroblasts. A cyclooxygenase-2 mediated pathway. (10942778)
2000
38
Interferon gene transfer by a hepatitis B virus vector efficiently suppresses wild-type virus infection. (10485909)
1999
39
Herpes virus type 8-negative primary effusion lymphoma associated with PAX-5 gene rearrangement and hepatitis C virus: a case report and review of the literature. (9850179)
1998
40
p53 protein expression by hepatocarcinogens in the rat liver and its potential role in mitoinhibition of normal hepatocytes as a mechanism of hepatic tumour promotion. (9163691)
1997
41
An unusual case of hepatic adenoma in a male. (7963373)
1994
42
A multicenter study on the prognosis of fulminant viral hepatitis: early prediction for liver transplantation. (8175127)
1994
43
A cross-sectional seroepidemiologic survey of chronic hepatitis B virus infections in Southeast Asian immigrants residing in a Canadian urban centre. (7867249)
1994
44
Insertional activation of mevalonate kinase by hepatitis B virus DNA in a human hepatoma cell line. (8302606)
1994
45
Effects of ursodeoxycholic acid (UDCA) on serum liver damage indices in patients with chronic active hepatitis. A double-blind controlled study. (1679391)
1991
46
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 40-1990. A 16-year-old boy with a seizure disorder and past meningitis, current hepatic failure, and free intraperitoneal air. (2169588)
1990
47
Granulomatous hepatitis in a healthy adult following BCG injection into a plantar wart. (605897)
1977
48
Extra-hepatic storage of copper: a male foetus suspected of Menkes' disease. (1176140)
1975
49
Studies of methylmalonyl coenzyme A carbonylmutase activity in methylmalonic acidemia. I. Correlation of clinical, hepatic, and fibroblast data. (239382)
1975
50
HEPATIC AND BILIARY TRACT DISEASE: A REVIEW OF RECENT SIGNIFICANT ADVANCES. (17857332)
1939

Genetic Variations for Hepatitis a

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Expression for genes affiliated with Hepatitis a

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hepatitis a

Search GEO for disease gene expression data for Hepatitis a.

Pathways for genes affiliated with Hepatitis a

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Sources:
29KEGG
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Pathways related to Hepatitis a according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.5TPI1, GPT, G6PD

Compounds for genes affiliated with Hepatitis a

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 2BitterDB
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Compounds related to Hepatitis a according to GeneCards/GeneDecks:

(show all 25)
idCompoundScoreTop Affiliating Genes
1lactate4410.8TPI1, F2, GPT, CD40LG, G6PD, LCN1
2creatinine4410.8LCN1, G6PD, CD40LG, GPT, F2, TPI1
3aspartate4410.8LCN1, G6PD, CD40LG, GPT, F2, TPI1
4ursodeoxycholic acid44 11 2412.8F2, GPT, CD40LG
5hyaluronic acid44 2411.8F2, GPT, CD40LG, LCN1
6mycophenolate mofetil44 49 1112.8CD40LG, GPT, SEPSECS
7p-cbp4410.8PCBP1, PCBP2
8alpha-tocopheryl acetate4410.8F2, G6PD
9ribavirin44 49 1112.8GPT, CD40LG, G6PD
10malate4410.8G6PD, GPT, TPI1
11ivig4410.8CD40LG, GPT, SEPSECS
12monoethylglycinexylidide4410.8GPT
13hepaplastin4410.8GPT, F2
14vitamin b124410.7GPT, CD40LG, G6PD
15ximelagatran44 1111.7GPT, F2
16acetaminophen44 2 49 11 2414.7F2, GPT, G6PD
17n acetylcysteine4410.7F2, GPT, CD40LG, G6PD
18uric acid44 2411.6LCN1, G6PD
19polyethylene glycol4410.6F2, CD40LG, G6PD
20aminopyrine4410.6F2, GPT
21ppack4410.5F2, CD40LG
22tirofiban44 1111.5F2, CD40LG
23poly c4410.5PCBP1, PCBP2
24alpha tocopherol4410.4TPI1, GPT, G6PD
25fructose-1,6-bisphosphate4410.2TPI1, G6PD

GO Terms for genes affiliated with Hepatitis a

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Sources:
16Gene Ontology
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Biological processes related to Hepatitis a according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1pentose-phosphate shuntGO:00609810.5TPI1, G6PD

Products for genes affiliated with Hepatitis a

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hepatitis a

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet