MCID: HPT003
MIFTS: 60

Hepatitis a malady

Infectious diseases, Liver diseases categories

Summaries for Hepatitis a

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8Disease Ontology, 33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Your liver is the largest organ inside your body. it helps your body digest food, store energy, and remove poisons. hepatitis is an inflammation of the liver. one type, hepatitis a, is caused by the hepatitis a virus (hav). the disease spreads through contact with an infected person's stool. you can get it from eating food made by an infected person who did not wash their hands after using the bathroom drinking untreated water or eating food washed in untreated water putting into your mouth a finger or object that came into contact with an infected person's stool having close contact with an infected person, such as through sex or caring for someone who is ill most people do not have any symptoms. if you do have symptoms, you may feel as if you have the flu. you may also have yellowish eyes and skin, called jaundice. a blood test will show if you have hav. hav usually gets better in a few weeks without treatment. however, some people can have symptoms for up to 6 months. your doctor may suggest medicines to help relieve your symptoms. the hepatitis a vaccine can prevent hav. good hygiene can also help. wash your hands thoroughly before preparing food, after using the toilet, or after changing a diaper. international travelers should be careful about drinking tap water. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Hepatitis a, also known as viral hepatitis, type a, is related to hepatitis and viral hepatitis, and has symptoms including fever, clay-colored bowel movements and fatigue. An important gene associated with Hepatitis a is HAVCR1 (hepatitis A virus cellular receptor 1), and among its related pathways is Carbon metabolism. The compounds lactate and creatinine have been mentioned in the context of this disorder. Affiliated tissues include liver, liver and kidney, and related mouse phenotype hematopoietic system.

Disease Ontology:8 A viral infectious disease that results in inflammation located in liver, has material basis in hepatitis a virus, which is transmitted by ingestion of contaminated food or water, or transmitted by direct contact with an infected person. the infection has symptom fever, has symptom fatigue, has symptom loss of appetite, has symptom nausea, has symptom vomiting, has symptom abdominal pain, has symptom clay-colored bowel movements, has symptom joint pain, and has symptom jaundice.

Wikipedia:63 Hepatitis A (formerly known as infectious hepatitis) is an acute infectious disease of the liver caused... more...

Aliases & Classifications for Hepatitis a

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Sources:
8Disease Ontology, 10DISEASES, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Liver diseases


Aliases & Descriptions:

hepatitis a 8 10 33 60
viral hepatitis, type a 8


External Ids:

Disease Ontology8 DOID:12549
MeSH34 D006506
SNOMED-CT56 154347003, 40468003
NCIt39 C3096
ICD1025 B15.0, B15.9

Related Diseases for Hepatitis a

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Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Hepatitis C family:

Hepatitis E Hepatitis B
Autoimmune Hepatitis Hepatitis D
hepatitis a Hepatitis
Viral Hepatitis Hepatitis C Virus

Diseases related to Hepatitis a via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 161)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis31.8GPT, F2, SEPSECS
2viral hepatitis31.1GPT, F2, G6PD, SEPSECS
3hepatitis b31.0F2, IFN1@, GPT
4autoimmune hepatitis30.9SEPSECS, CD40LG, GPT, F2
5hepatitis c30.8IFN1@, CD40LG, F2, GPT
6hepatitis e30.8CD40LG, GPT
7cholecystitis30.3GPT
8acute liver failure30.3F2, GPT
9cholestasis30.2GPT, F2
10malaria30.1TPI1, G6PD
11encephalomyelitis30.1HAVCR2, IFN1@
12acute pancreatitis30.0GPT
13infectious mononucleosis30.0TPI1, CD40LG
14asthma29.6LCN1, HAVCR1, HAVCR2, TBX21
15lupus erythematosus29.6CD40LG, F2
16primary biliary cirrhosis29.6SEPSECS, F2, GPT, CD40LG
17sclerosing cholangitis29.6SEPSECS
18rheumatoid arthritis29.6HAVCR1, CD40LG
19cholangitis29.6GPT, SEPSECS
20deficiency anemia29.6G6PD, TPI1, F2
21galactosemia29.6GPT, SEPSECS, G6PD, F2
22scrub typhus29.6CD40LG, GPT
23dengue hemorrhagic fever29.6CD40LG
24alcoholic hepatitis10.6
25typhoid fever10.4
26granulomatous hepatitis10.3
27acalculous cholecystitis10.2
28drug-induced hepatitis10.2
29mumps10.2
30influenza10.2
31rubella10.1
32pure red-cell aplasia10.1
33measles10.1
34liver disease10.1
35purpura10.1
36diphtheria10.1
37acute disseminated encephalomyelitis10.1
38autoimmune hemolytic anemia10.1
39hepatitis d10.1
40hemolytic anemia10.1
41hepatocellular carcinoma10.1
42tetanus10.1
43myelitis10.0
44renal clear cell carcinoma10.0
45cerebritis10.0
46celiac disease10.0
47yellow fever10.0
48encephalitis10.0
49inflammatory bowel disease10.0
50pancreatitis10.0

Graphical network of the top 20 diseases related to Hepatitis a:



Diseases related to hepatitis a

Clinical Features for Hepatitis a

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Sources:
8Disease Ontology
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Symptoms:

8 (show all 9)
  • fever
  • clay-colored bowel movements
  • fatigue
  • loss of appetite
  • jaundice
  • joint pain
  • abdominal pain
  • nausea
  • vomiting

Drugs & Therapeutics for Hepatitis a

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Hepatitis a

Drug clinical trials:

Search ClinicalTrials for Hepatitis a

Search NIH Clinical Center for Hepatitis a

Search CenterWatch for Hepatitis a

Genetic Tests for Hepatitis a

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Anatomical Context for Hepatitis a

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Hepatitis a:

32
Liver, Kidney, Testes, Skin, T cells, Thyroid, Brain, Eye, B cells, Bone, Bone marrow, Endothelial, Lung, Colon, Heart, Pancreas, Monocytes, Nk cells, Myeloid, Breast, Tongue, Prostate, Spinal cord, Lymph node, Smooth muscle, Ovary, Adipocyte, Salivary gland, Cortex, Testis, Prefrontal cortex, Cingulate cortex, Thalamus, Fetal liver, Spleen, Placenta, Pituitary, Skeletal muscle, Small intestine, Whole blood

FMA organs/tissues related to Hepatitis a:

14
Liver

Animal Models for Hepatitis a or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Hepatitis a:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539710.5TPI1, F2, CD40LG, TBX21, G6PD, HAVCR2

Publications for Hepatitis a

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Sources:
50PubMed
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Articles related to Hepatitis a:

(show top 50)    (show all 5560)
idTitleAuthorsYear
1
Hepatitis a screening for internationally adopted children from hepatitis a endemic countries. (24137028)
2014
2
Marked genomic heterogeneity of rat hepatitis E virus strains in Indonesia demonstrated on a full-length genome analysis. (24231359)
2013
3
An open, prospective, randomized study comparing the immunogenicity and safety of two inactivated hepatitis A pediatric vaccines in toddlers, children and adolescents in China. (23334341)
2013
4
Clinical and laboratory features of viral hepatitis A in children. (23358879)
2013
5
Hepatitis B virus-specific T-cell responses during IFN administration in a small cohort of chronic hepatitis B patients under nucleos(t)ide analogue treatment. (24251783)
2013
6
Drug induced autoimmune hepatitis and TNF-I+ blocking agents: is there a real relationship? (22841985)
2013
7
Prevalence of hepatitis A virus, hepatitis B virus, hepatitis C virus, hepatitis D virus and hepatitis E virus as causes of acute viral hepatitis in North India: a hospital based study. (23883712)
2013
8
A zebrafish model of intrahepatic cholangiocarcinoma by dual expression of hepatitis B virus X and hepatitis C virus core protein in liver. (22729936)
2012
9
Let-7b is a novel regulator of hepatitis C virus replication. (22391672)
2012
10
Cross-species infection of pigs with a novel rabbit, but not rat, strain of hepatitis E virus isolated in the United States. (22535776)
2012
11
Broadly neutralizing immune responses against hepatitis C virus induced by vectored measles viruses and a recombinant envelope protein booster. (22896607)
2012
12
Prolonged cholestasis following hepatitis a virus infection: revisiting the role of steroids. (23055653)
2012
13
Investigation of a severe nosocomial outbreak of hepatitis A among healthcare workers and adult patients. (21277653)
2011
14
Imputing QALYs from single time point health state descriptions on the EQ-5D and the SF-6D: a comparison of methods for hepatitis a patients. (21296602)
2011
15
A randomized trial of viral hepatitis prevention among underprivileged people in the Lyon area of France. (20876189)
2011
16
Oral acetyl-L-carnitine therapy reduces fatigue in overt hepatic encephalopathy: a randomized, double-blind, placebo-controlled study. (21310833)
2011
17
PAI-1 plays a protective role in CCl4-induced hepatic fibrosis in mice: role of hepatocyte division. (20203062)
2010
18
Interleukin 18 promoter variants (-137G>C and -607C>A) in patients with chronic hepatitis C: association with treatment response. (19455410)
2009
19
Supraduodenal branch of the left hepatic artery: a rare cause of bleeding duodenal ulcer. (18797965)
2009
20
NKG2D-retinoic acid early inducible-1 recognition between natural killer cells and Kupffer cells in a novel murine natural killer cell-dependent fulminant hepatitis. (19177594)
2009
21
Left-sided gallbladder: a complicated percutaneous cholecystostomy and subsequent hepatic embolisation. (19541942)
2009
22
An analysis of risk factors for developing Hepatocellular carcinoma in a group of Hepatitis C patients with stage 3 fibrosis following interferon therapy. (19259418)
2008
23
Gianotti-Crosti syndrome following hepatitis A vaccination. (19067881)
2008
24
Clinical outcomes and predictive factors of spontaneous survival in patients with fulminant hepatitis A]. (19119242)
2008
25
Characterization of hepatic progenitors from human fetal liver using CD34 as a hepatic progenitor marker. (17511030)
2007
26
Agenesis of the hepatic vena cava in a patient with scimitar syndrome. (17481373)
2007
27
Hypertensive crisis, hepatitis B virus and polyarteritis nodosa in a child. (17106693)
2007
28
Epigallocatechin-3-gallate, a polyphenol component of green tea, suppresses both collagen production and collagenase activity in hepatic stellate cells. (16142404)
2005
29
Epigallocatechin-3-gallate, a green-tea polyphenol, suppresses Rho signaling in TWNT-4 human hepatic stellate cells. (15976760)
2005
30
Congenital hepatic fibrosis: a very uncommon cause of pancytopenia in children. (16217264)
2005
31
Hepatic tuberculosis presenting as cholestatic jaundice. A case report. (16737053)
2005
32
Acute hepatic failure with deep hepatic coma treated successfully by high-flow continuous hemodiafiltration and living-donor liver transplantation: a case report. (12591456)
2003
33
Triple therapy with amantadine in treatment-naive patients with chronic hepatitis C: a placebo-controlled trial. (12774015)
2003
34
Severe manifestation of acute hepatitis A recently found in Gunma, Japan. (12162409)
2002
35
PKHD1, the polycystic kidney and hepatic disease 1 gene, encodes a novel large protein containing multiple immunoglobulin-like-plexin- transcription-factor domains and parallel beta-helix 1 repeats. (11898128)
2002
36
Acute viral hepatitis A and parvovirus B19 infections complicated by pure red cell aplasia and autoimmune hemolytic anemia. (12076880)
2002
37
Treatment of patients with chronic hepatitis C not responding to interferon with high-dose interferon alpha with or without ribavirin: final results of a prospective randomized trial. Austrian Hepatitis Study Group. (11434597)
2001
38
Hepatic capillariasis in rats: a new model for testing antifibrotic drugs. (11050664)
2000
39
Fulminant hepatitis A in a patient with severe hyperthyroidism: rapid recovery from hepatic coma after plasmapheresis and total thyroidectomy. (10843149)
2000
40
Latent autoimmune thyroiditis in untreated patients with HCV chronic hepatitis: a case-control study. (10677250)
2000
41
NS5A, a nonstructural protein of hepatitis C virus, binds growth factor receptor-bound protein 2 adaptor protein in a Src homology 3 domain/ligand-dependent manner and perturbs mitogenic signaling. (10318918)
1999
42
Development of a high grade dysplastic nodule in a case of congenital hepatic fibrosis. (10425575)
1999
43
The GOR47-1 sequence in human DNA encoding for a potential autoantigen in connection with hepatitis C--a sequence not only reserved for humans. (9846365)
1998
44
Hepatitis C virus infection in mixed cryoglobulinemia and B-cell non-Hodgkin's lymphoma: evidence for a pathogenetic role. (9349300)
1997
45
Hepatitis C virus nonstructural region 5A protein is a potent transcriptional activator. (9343247)
1997
46
Hepatic angiomyolipoma. A report of four cases with immunohistochemical and DNA-flow cytometric studies. (8554448)
1996
47
Leukoerythroblastosis with blasts in a patient with alcoholic hepatitis. (3571897)
1987
48
A metabolic disorder similar to Zellweger syndrome with hepatic acatalasia and absence of peroxisomes, altered content and redox state of cytochromes, and infantile cirrhosis with hemosiderosis. (844460)
1977
49
Granulomatous hepatitis accompanying a self-limited febrile disease. (4172654)
1968
50
Metastatic carcinomatous cirrhosis of the liver; report of a case in which death followed hemorrhage from esophageal varices and hepatic coma. (13487029)
1958

Genetic Variations for Hepatitis a

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Expression for genes affiliated with Hepatitis a

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hepatitis a

Search GEO for disease gene expression data for Hepatitis a.

Pathways for genes affiliated with Hepatitis a

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Sources:
29KEGG
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Pathways related to Hepatitis a according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.5TPI1, GPT, G6PD

Compounds for genes affiliated with Hepatitis a

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 2BitterDB
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Compounds related to Hepatitis a according to GeneCards/GeneDecks:

(show all 25)
idCompoundScoreTop Affiliating Genes
1lactate4410.8CD40LG, TPI1, F2, GPT, G6PD, LCN1
2creatinine4410.8TPI1, G6PD, F2, GPT, CD40LG, LCN1
3aspartate4410.8GPT, G6PD, TPI1, LCN1, CD40LG, F2
4ursodeoxycholic acid44 11 2412.8CD40LG, GPT, F2
5hyaluronic acid44 2411.8GPT, CD40LG, LCN1, F2
6mycophenolate mofetil44 49 1112.8CD40LG, SEPSECS, GPT
7p-cbp4410.8PCBP2, PCBP1
8alpha-tocopheryl acetate4410.8G6PD, F2
9ribavirin44 49 1112.8G6PD, CD40LG, GPT
10ivig4410.8CD40LG, GPT, SEPSECS
11malate4410.8GPT, G6PD, TPI1
12hepaplastin4410.8F2, GPT
13monoethylglycinexylidide4410.7GPT
14vitamin b124410.7G6PD, GPT, CD40LG
15ximelagatran44 1111.7GPT, F2
16acetaminophen44 2 49 11 2414.7GPT, G6PD, F2
17n acetylcysteine4410.7GPT, F2, G6PD, CD40LG
18uric acid44 2411.6G6PD, LCN1
19polyethylene glycol4410.6G6PD, CD40LG, F2
20aminopyrine4410.6GPT, F2
21ppack4410.5CD40LG, F2
22tirofiban44 1111.5F2, CD40LG
23poly c4410.5PCBP2, PCBP1
24alpha tocopherol4410.4G6PD, GPT, TPI1
25fructose-1,6-bisphosphate4410.2G6PD, TPI1

GO Terms for genes affiliated with Hepatitis a

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16Gene Ontology
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Biological processes related to Hepatitis a according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1pentose-phosphate shuntGO:00609810.5TPI1, G6PD

Products for genes affiliated with Hepatitis a

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hepatitis a

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet