HBV
MCID: HPT016

Summaries for Hepatitis B

Sources:
6Disease Ontology, 23MedlinePlus, 44Wikipedia, 22MalaCards
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MedlinePlus: Hepatitis b is one type of hepatitis - a liver disease- caused by the hepatitis b virus (hbv). hepatitis b spreads by contact with an infected person's blood, semen or other body fluid. an infected woman can give hepatitis b to her baby at birth. if you get hbv, you may feel as if you have the flu, or you may have no symptoms at all. a blood test can tell if you have it. hbv usually gets better on its own after a few months. if it does not get better, it is called chronic hbv, which lasts a lifetime. chronic hbv can lead to scarring of the liver, liver failure or liver cancer. there is a vaccine for hbv. it requires three shots. all babies should get the vaccine, but older children and adults can get it too. if you travel to countries where hepatitis b is common, you should get the vaccine. nih: national institute of diabetes and digestive and kidney diseases23

MalaCards: Hepatitis B, also known as hepatitis b, chronic, is related to carcinoma and leukemia, and has symptoms including fever, fatigue and loss of appetite. An important gene associated with Hepatitis B is RSF1 (remodeling and spacing factor 1), and among its related pathways are Antioxidant Action of Vitamin-C and ERK Signaling. The drugs adefovir dipivoxil and adefovir and the compounds estrogen and thymidine have been mentioned in the context of this disorder. Affiliated tissues include liver, liver and bone marrow, and related mouse phenotypes are cellular and homeostasis/metabolism.

Disease Ontology: A viral infectious disease that results in inflammation located in liver, has material basis in hepatitis b virus, which is transmitted by sexual contact, transmitted by blood transfusions, and transmitted by fomites like needles or syringes. the infection has symptom fever, has symptom fatigue, has symptom loss of appetite, has symptom nausea, has symptom vomiting, has symptom abdominal pain, has symptom clay-colored bowel movements, has symptom joint pain, and has symptom jaundice.6

Wikipedia: Hepatitis B is an infectious inflammatory illness of the liver caused by the hepatitis B virus (HBV)...44 more...

Aliases & Descriptions for Hepatitis B

Sources:
6Disease Ontology, 8DISEASES, 32Novoseek , 23MedlinePlus, 43UMLS, 26NCBI Bookshelf, 40SNOMED-CT, 27NCIt, 24MeSH
See all sources

Aliases & Descriptions:

hepatitis b 6 8 32 23 43
hepatitis b, chronic 43
chronic hepatitis b 6
hepatitis b chronic 32
hbv 26

External Ids:

NCIt27 C3097
SNOMED-CT40 186625003, 154348008, 66071002 266195001, more

Related Diseases for Hepatitis B

Sources:
13GeneCards, 14GeneDecks
See all sources

Disease types for hepatitis c family:

hepatitis a hepatitis e
hepatitis d hepatitis b
hepatitis

Diseases related to hepatitis b by text searches and GeneDecks gene sharing:

(show top 50)    (show all 840)
idRelated DiseaseScoreTop Affiliating Genes
1carcinoma203.3PIK3CA, PIK3R1, PIK3C2A, PIK3CG, PIN1, PIM1
2leukemia173.2PIK3CA, PIK3R1, PIK3C2A, PIK3CG, PIN1, PIM1
3hepatocellular carcinoma137.9PIK3CA, PIK3R1, PIK3CG, PIN1, KLF6, PDCD1
4pancreatitis120.1PIK3CA, PIK3R1, PIK3C2A, PIK3CG, PIN1, PIM1
5thyroiditis109.3PIK3CA, PIK3R1, PIK3C2A, PIK3CG, PIN1, NCOA6
6lupus erythematosus102.5PIK3C2A, PIK3CG, SH2B3, NCF2, PDCD1, PDCD1LG2
7fibrosis99.9PIK3CA, PIK3CG, PIN1, KLF6, NCF2, RELA
8cervicitis93.0PIK3CA, PIK3CG, PIN1, NCR1, NCR2, PDCD1
9hypoxia86.6PIK3CA, PIK3R1, PIK3C2A, PIK3CG, PIM1, RELA
10prostatitis85.8PIK3CA, PIK3R1, PIK3C2A, PIK3CG, PIN1, PIM1
11influenza85.5PIK3CA, PIK3R1, PIK3C2A, PIK3CG, NCR1, NCR2
12atherosclerosis84.0PIK3C2A, PIK3CG, NCF2, PDCD1, RETN, VTN
13diabetes mellitus81.5PIK3CA, PIK3R1, PIK3C2A, PIK3CG, SH2B3, PDCD1
14cholesterol80.1PIK3CA, PIK3R1, PIK3C2A, PIK3CG, NCF2, NCOA6
15psoriasis79.8RETN, KIR2DS3, KIR2DS5, KIR3DL2, KIR3DL3, KIR2DP1
16neuronitis77.2ZNF638, PIK3CA, PIK3R1, PIK3C2A, PIK3CG, PIN1
17melanoma74.5PIK3CA, PIK3R1, PIK3C2A, PIK3CG, PIM1, KLF6
18retinitis72.8PIK3CA, PIK3C2A, PIK3CG, PIM1, COCH, KLF6
19colorectal cancer70.7PIK3CA, PIK3R1, PIK3CG, PIN1, KLF6, RFX2
20cervical cancer70.0PIK3CA, PIK3CG, PIN1, NCR1, NCR2, PDCD1
21adenocarcinoma69.6PIK3CA, PIK3R1, PIK3C2A, PIK3CG, PIN1, PIM1
22anemia69.5PIM1, RFX1, PDCD1, RELA, KITLG, SFXN4
23gonococcal synovitis69.4PIK3CA, PIK3R1, PIK3CG, PDCD1, RELA, RETN
24nephropathy68.0PDCD1, RELA, RETN, KITLG, VTN, PCNA
25squamous cell carcinoma66.6PIK3CA, PIN1, PIM1, RELA, VTN, PCNA
26ischemia63.5PIK3CA, PIK3C2A, PIK3CG, RELA, RETN, KITLG
27systemic lupus erythematosus62.1PDCD1, VTN, SELE, VIP, NAT2, VCAM1
28ovarian cancer61.2PIK3CA, PIK3R1, PIK3CG, KLF6, PDCD1, RELA
29immunodeficiency61.2PDCD1, KIR3DL1, VIP, BPI, MYD88, BMP6
30peritonitis60.2PIK3C2A, NCR1, NCR2, RELA, KIR2DL1, KIR2DL3
31myeloma58.5PIK3CA, PIK3R1, PIK3CG, NCR1, NCR2, RELA
32gastric cancer57.8PIK3CA, PIK3R1, PIK3CG, PIN1, PIM1, KLF6
33viral hepatitis55.9PCNA, SERPINC1, SERPINA1, MYB, CLIC1, UROD
34liver cancer54.8PIK3CG, PIN1, RB1, RBMY1A1, SERPINA1, NAT1
35esophagitis54.6PIK3CA, PIK3C2A, PIK3CG, PIN1, PIM1, LRMP
36hepatitis54.2SERPINA1, CD58, ASGR2, GZMB, MGAT3, GSR
37myeloid leukemia54.1PIK3CA, PIK3R1, PIK3C2A, PIK3CG, PIN1, PIM1
38glomerulonephritis53.3KITLG, VTN, PCNA, SERPINC1, SERPINE1, SERPING1
39insulin resistance53.1PIK3CA, PIK3R1, PIK3CG, RELA, RETN, PCK2
40hepatitis c53.1SERPINA1, BCL6, CIITA, MX1, MTTP, JUN
41colon cancer53.1PIK3CA, PIK3R1, PIK3CG, KLF6, RELA, RETN
42blindness52.6PIK3C2A, PIK3CG, SELE, SERPINC1, SERPINA7, SEPP1
43alzheimer's disease52.1PIK3CA, PIK3R1, PIK3CG, PIN1, LRIT1, KLF6
44ataxia51.6PIK3CA, PIK3R1, PIK3CG, PIN1, NCK2, PCNA
45breast carcinoma51.5PIK3CA, PIK3R1, PIK3CG, CNTN2, KIF1B, KITLG
46liver cirrhosis51.5RETN, VTN, SERPINC1, SERPINB3, SERPINA7, SERPINA1
47cholangiocarcinoma50.7PIK3CA, PIK3CG, PCNA, RB1, SELE, SERPINA1
48lymphocytic leukemia50.3PIK3CA, PIK3CG, PDCD1LG2, RELA, REV3L, CNTN2
49neuropathy49.7PIK3C2A, RETN, CNTFR, KIF1B, BTD, SELE
50galactosemia49.7PDCD1, RETN, VTN, BTD, SERPINC1, SERPINA7

Graphical network of the top 20 diseases related to hepatitis b:



Graphical network of diseases related to hepatitis b

Clinical Features for Hepatitis B

Sources:
6Disease Ontology
See all sources
Symptoms: fever, fatigue, loss of appetite, nausea, vomiting, abdominal pain, clay-colored bowel movements, joint pain, jaundice.6

Drugs & Therapeutics for Hepatitis B

Sources:
4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
See all sources

Approved drugs:

Search CenterWatch for hepatitis b

Drug clinical trials:

Search ClinicalTrials for hepatitis b

Search NIH Clinical Center for hepatitis b

Search CenterWatch for hepatitis b

Inferred drug relations via UMLS/NDF-RT:

43 28 adefovir, adefovir dipivoxil, interferon alfa-2b

Genetic Tests for Hepatitis B

Anatomical Context for Hepatitis B

Sources:
11FMA, 22MalaCards
See all sources

MalaCards organs/tissues related to hepatitis b:

22
Liver, Bone marrow, Whole blood, Spinal cord, Small intestine, Kidney, Thyroid, Breast, Myeloid, Monocytes, Nk cells, T cells, B lymphoblasts, B cells, Endothelial, Fetal liver, Fetal thyroid, Pituitary

FMA organs/tissues related to hepatitis b:

11
Liver

Phenotypes for genes affiliated with Hepatitis B

Sources:
25MGI
See all sources

MGI Mouse Phenotypes related to hepatitis b:

25 (show all 29)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1cellular phenotypeMP:000538471.0PIK3CA, PIK3R1, PIK3CG, PIN1, PIM1, SH2B2
2homeostasis/metabolism phenotypeMP:000537670.1PIK3CA, PIK3R1, PIK3C2A, PIK3CG, SH2B2, SH3BP2
3mortality/agingMP:001076868.7PIK3CA, PIK3C2A, SH3BP2, KLF15, KLF6, RFX1
4hematopoietic system phenotypeMP:000539754.1PIM1, SH2B2, SH2B3, SH3BP2, KLF6, NCR1
5growth/size phenotypeMP:000537849.5PIK3CA, PIK3R1, PIK3C2A, PIK3CG, PIN1, PIM1
6cardiovascular system phenotypeMP:000538544.8PIK3CA, PIK3R1, PIK3CG, KLF15, KLF6, RFX3
7nervous system phenotypeMP:000363138.0SH3BP2, NCK1, NCK2, NCOA6, PDCD1, RELA
8normal phenotypeMP:000287336.3PIK3R1, COCH, RFX3, NCK1, NCK2, NCR1
9behavior/neurological phenotypeMP:000538635.7PIK3CA, NCK1, NCK2, SGSH, CNTFR, CNTN2
10integument phenotypeMP:001077133.9PIK3CG, PIN1, SH3BP2, KLF6, NCOA6, RELA
11reproductive system phenotypeMP:000538931.5PIK3CA, KLF6, NCOA6, SFTPC, SERPINA5, SEPP1
12digestive/alimentary phenotypeMP:000538131.3SH3BP2, NCOA6, KITLG, RB1, VHL, VEGFA
13tumorigenesisMP:000200630.9PIK3CA, PIK3R1, PDCD1LG2, REV3L, KITLG, SFTPC
14embryogenesis phenotypeMP:000538028.7PIK3CA, KLF6, RFX3, NCK1, NCK2, NCOA6
15muscle phenotypeMP:000536927.5PIK3CA, PIK3R1, PIK3CG, SH3BP2, KLF15, NCOA6
16skeleton phenotypeMP:000539027.5PIK3CG, SH3BP2, RELA, SGSH, KIF1B, KITLG
17immune system phenotypeMP:000538727.4REV3L, VDR, MYD88, MYB, RAF1, CIITA
18liver/biliary system phenotypeMP:000537027.3SH3BP2, KLF15, KLF6, NCOA6, RETN, SGSH
19vision/eye phenotypeMP:000539127.2PIK3CA, PIN1, SH3BP2, NCOA6, PDCD1, RELA
20renal/urinary system phenotypeMP:000536726.3KLF15, NCK1, NCK2, PDCD1, SGSH, BTD
21no phenotypic analysisMP:000301223.3PIK3R1, PDCD1LG2, SFTPC, PCNA, RB1, BST2
22respiratory system phenotypeMP:000538822.3SH3BP2, KIF1B, SFTPC, SFTPD, NAB2, VDAC3
23adipose tissue phenotypeMP:000537518.8PIK3CA, PIK3R1, PIK3C2A, KLF15, RETN, RB1
24limbs/digits/tail phenotypeMP:000537118.5NCOA6, RELA, KITLG, RB1, SEPP1, VHL
25craniofacial phenotypeMP:000538217.2SH3BP2, NCOA6, REV3L, SGSH, KITLG, MYCN
26hearing/vestibular/ear phenotypeMP:000537716.6COCH, KITLG, RB1, VDR, MYC, MYD88
27pigmentation phenotypeMP:000118614.9NCOA6, KITLG, BTD, RB1, SERPINC1, SEMA4A
28other phenotypeMP:000539514.4SH2B3, RARB, JAK2, CDKN2A, CD40LG, ITGB1
29endocrine/exocrine gland phenotypeMP:000537913.7SERPINA5, CD40LG, IL2, IL22, IL2RB, FASLG

Publications for genes affiliated with Hepatitis B

Sources:
35PubMed
See all sources

Articles related to hepatitis b:

(show top 50)    (show all 2009)
idTitleAuthorsYearAffiliating Genes
1I+-2-HS-glycoprotein is a potential marker predicting hepatitis B e antigen seroconversion in patients with chronic hepatitis B durin g treatment with pegylated interferon alpha-2b. (21253869)Ma H.... Wei L.2011AHSG
2Hepatitis B spliced protein (HBSP) generated by a spl iced hepatitis B virus RNA participates in abnormality of fibrin formation and functions by binding to fibrinogen I^ chain. (20981788)Chen J.Y.... Lin X.2010FGG
3Extended lamivudine consolidation therapy in hepatiti s B e antigen-positive chronic hepatitis B patients improves sustained hepatiti s B e antigen seroconversion. (20030580)Kuo Y.H.... Lee C.M.2010GPT
4Comparison between quantitative hepatitis B surface a ntigen, hepatitis B e-antigen and hepatitis B virus DNA levels for predicting v irological response to pegylated interferon-alpha-2b therapy in hepatitis B e-a ntigen-positive chronic hepatitis B. (20070399)Tangkijvanich P.... Poovorawan Y.2010IFNA2
5Correlation of liver stiffness and histological featu res in healthy persons and in patients with occult hepatitis B, chronic active hepatitis B, or hepatitis B cirrhosis. (19920809)Fung J.... Yuen M.F.2010GPT
6Dynamic changes of Th1/Th2 type cytokines in peripheral blood of patients with hepatitis B e antigen-positive chronic hepatitis B treated with telbivudine. (19335978)Zhang L.... Guo S.H.2009IFNG, IL10
7Liver X receptor mediates hepatitis B virus X protein-induced lipogenesis in hepatitis B virus-associated hepatocellular carcinoma. (19105208)Na T.Y.... Lee M.O.2009FASN, NR1H2, NR1H3
8Rescue monotherapy in lamivudine-resistant hepatitis B e antigen-positive chronic hepatitis B: adefovir versus entecavir. (19704174)Lee J.M.... Ahn S.H.2009GPT
9The correlation of hepatocyte nuclear factor 4 alpha and 3 beta with hepatitis B virus replication in the liver of chronic hepatitis B patients. (19302415)Long Y.... Tang H.2009HNF4A, FOXA2
10Role of genotype and precore/basal core promoter mutations of hepatitis B virus in patients with chronic hepatitis B with acute exacerbation. (18224565)Tsai W.L.... Lin H.H.2008ABCB7
11Sustained hepatitis B e antigen seroconversion in patients with chronic hepatitis B after adefovir dipivoxil treatment: analysis of precore and basal core promoter mutants. (18840078)Wu I.C.... Chang T.T.2008GPT
12Is there a meaningful serum hepatitis B virus DNA cutoff level for therapeutic decisions in hepatitis B e antigen-negative chronic hepatitis B virus infection? (18924246)Papatheodoridis G.V.... Archimandritis A.J.2008LOC100128356
13Mutation of hepatitis B virus S gene in children with hepatitis B virus-associated glomerulonephritis (19099758)Zhu H.... Fang F.2008PTK2B
14Treatment paradigms on hepatitis B e antigen-negative chronic hepatitis B patients. (17501691)Hadziyannis S.J.2007IFNA1
15Effect of interferon-alpha treatment in children with hepatitis B e antigen-positive chronic hepatitis B virus infection: a meta-analysis of follow-up for six months to two years (18021533)Lin Z.Q.... Chen Q.2007IFNA1
16Predictive factors for reactivation of hepatitis B following hepatitis B e antigen seroconversion in chronic hepatitis B. (17935720)Chu C.M.... Liaw Y.F.2007GPT
17Mutations in preS genes of genotype C hepatitis B virus in patients with chronic hepatitis B and hepatocellular carcinoma. (17876546)Gao Z.Y.... Zhuang H.2007GPT
18Changes of Toll-like receptor (TLR) 2 and TLR4 on the peripheral blood mononuclear cells in patients with chronic hepatitis B and chronic severe hepatitis B (17524268)Wei X.Q.... Yao J.L.2007TLR2, TLR4
19Predictive factors of hepatitis B virus DNA negative conversion among patients with chronic hepatitis B during lamivudine therapy (17971944)Chen J.L.... Fan X.L.2007ALB
20Genotype B and younger patient age associated with better response to low-dose therapy: a trial with pegylated/nonpegylated interferon-alpha-2b for hepatitis B e antigen-positive patients with chronic hepatitis B in China. (17243057)Zhao H.... Si C.W.2007IFNA2
21Hepatitis B virus replication is regulated by the acetylation status of hepatitis B virus cccDNA-bound H3 and H4 histones. (16530522)Pollicino T.... Levrero M.2006HDAC1
2248 weeks pegylated interferon alpha-2a is superior to 24 weeks of pegylated interferon alpha-2b in achieving hepatitis B e antigen seroconversion in chronic hepatitis B infection. (16611278)Hui C.K.... Lau G.K.2006IFNA2
23Hepatitis B genotypes: relation to clinical outcome in patients with chronic hepatitis B in Saudi Arabia. (17109498)Abdo A.A.... Al-Faleh F.Z.2006ALB
24Hepatitis B virus genotypes and alanine aminotransferase levels in HBeAg negative patients with chronic hepatitis B and liver cirrhosis (16042881)Li J.Q.... Duan X.Z.2005GPT
25Comparison of recurrence after hepatic resection in p atients with hepatitis B vs. hepatitis C-related small hepatocellular carcinoma in hepatitis B virus endemic area. (15780044)Huang Y.H.... Lee S.D.2005ALB
26Efficacy of hepatitis B vaccination and interferon-alpha-2b combination therapy versus interferon-alpha-2b monotherapy in children with chronic hepatitis B. (15209626)Helvaci M.... Sozen G.2004IFNA2, IFNA1
27Adefovir dipivoxil added to ongoing lamivudine in chr onic hepatitis B with YMDD mutant hepatitis B virus. (14699490)Perrillo R.... Schiff E.2004GPT
28Long-term outcomes of thymosin-alpha 1 and interferon alpha-2b combination therapy in patients with hepatitis B e antigen (HBeAg) negative chronic hepatitis B. (12820143)Saruc M.... Yuceyar H.2003IFNA2, PTMA
29Role of hepatitis B virus genotypes in chronic hepatitis B exacerbation. (12905145)Yuen M.F.... Lai C.L.2003ALB
30Individualization of interferon therapy using serum hepatitis B virus DNA to reduce viral relapse in patients with chronic hepatitis B: a randomized controlled trial. (12702905)Chung Y.H.... Suh D.J.2003IFNA1
31Peginterferon alpha-2a (40 kDa): an advance in the treatment of hepatitis B e antigen-positive chronic hepatitis B. (12823597)Cooksley W.G.... Pluck N.2003IFNA2
32Effect of multiple mutations in the core promoter and pre-core/core region of hepatitis B virus genome on the response to interferon in e antigen-positive chronic hepatitis B. (11354277)Zhang X.... Zhang D.2001IFNA1
33Lamivudine as an alternative therapy for interferon-r esistant chronic hepatitis B and the characteristics of hepatitis B virus: a ca se report. (11038017)Terui Y.... Takahashi T.2000IFNA1
34Clinical evaluation of the branched DNA assay for hepatitis B virus DNA detection in patients with chronic hepatitis B lacking hepatitis B e antigen and treated with interferon-alpha. (9857350)Habersetzer F.... TrAcpo C.1998IFNA1
35Placebo-controlled trial of vaccination with hepatitis B virus surface antigen in hepatitis B virus transgenic mice. (9148003)Akbar S.M.... Onji M.1997SLC26A5
36Are alanine aminotransferase, hepatitis B virus DNA or IgM antibody to hepatitis B core antigen serum levels predictors of histological grading in chronic hepatitis B? (9138277)Zavaglia C.... IDEO G.1997CD40LG, GPT
37A hepatitis B virus mutant with a new hepatocyte nuclear factor 1 binding site emerging in transplant-transmitted fulminant hepatitis B. (9185776)Pult I.... Blum H.E.1997HNF1A
38Interferon-alpha 2b treatment in hepatitis B carriers. Effect on hepatitis B virus DNA levels in children infected with different genotypes. (9055880)Sangfelt P.... Reichard O.1997IFNA2
39A randomized controlled trial of thymosin-alpha1 vers us interferon alfa treatment in patients with hepatitis B e antigen antibody--a nd hepatitis B virus DNA--positive chronic hepatitis B. (8855175)Andreone P.... Gasbarrini G.1996PTMA
40Microwave treatment of serum facilitates detection of hepatitis B virus DNA by the polymerase chain reaction. Results of a study in anti-HBe positive chronic hepatitis B. (7751585)Costa J.... RodAcs J.1995GPT
41Genetic heterogeneity in the precore region of hepatitis B virus in hepatitis B e antigen-negative chronic hepatitis B patients: spontaneous seroconversion and interferon-induced seroconversion. (7666040)Karasawa T.... Toda G.1995IFNA1
42Induction of T-helper cell response to hepatitis B core antigen in chronic hepatitis B: a major factor in activation of the host immune response to the hepatitis B virus. (7557849)Marinos G.... Williams R.1995IFNG
43Mutant p53 but not hepatitis B virus X protein is present in hepatitis B virus-related human hepatocellular carcinoma. (8521397)Henkler F.... Koshy R.1995RSF1
44Expression of insulin-like growth factor II in hepatitis B, cirrhosis and hepatocellular carcinoma: its relationship with hepatitis B virus antigen expression. (7927218)Su Q.... Yang J.J.1994IGF2
45Interferon-gamma production specific for hepatitis B virus antigen by intrahepatic T lymphocytes in patients with acute and chronic hepatitis B. (8273806)Kakumu S.... Kusakabe A.1994IFNG
46Hepatitis B x antigen and polymerase antibodies in the serum of hepatitis B carriers with or without hepatitis delta virus infection. Effects of interferon treatment. (1500693)Lega L.... Feitelson M.A.1992IFNA1
47Hepatitis B core antigen-specific interferon gamma production of peripheral blood mononuclear cells during acute exacerbation of chronic hepatitis B. (1384110)Takehara T.... Kamada T.1992IFNG
48Enhancement of hepatitis-B surface-antigen expression by 5-azacytidine in a hepatitis-B-virus-transfected cell line. (1379994)Miyoshi E.... Taniguchi N.1992AFP
49Gamma-interferon production in response to hepatitis B core protein and its synthetic peptides in patients with chronic hepatitis B virus infection. (1707382)Wakita T.... Mayumi M.1990IFNG
50Long-term evolution of chronic hepatitis B in children with antibody to hepatitis B e antigen. (2319401)Bortolotti F.... Marazzi M.G.1990GPT

Expression for genes affiliated with Hepatitis B

Sources:
1BioGPS
See all sources
Expression patterns in normal tissues for genes affiliated with Hepatitis B

Pathways for genes affiliated with Hepatitis B

Sources:
36QIAGEN, 20KEGG, 10EMD Millipore, 41Thomson Reuters
See all sources

Pathways related to hepatitis b according to GeneDecks:

(show top 50)    (show all 306)
idPathwayScoreTop Affiliating Genes
1Antioxidant Action of Vitamin-C3629.0NCF2, KITLG, VEGFC, BMP1, BMP10, BMP6
2ERK Signaling3623.8PIK3R1, KITLG, VEGFC, MYC, BMP1, BMP10
3Tuberculosis2023.3RELA, VDR, MYD88, RAF1, BID, CLEC4E
4Influenza A2022.6PIK3CA, PIK3R1, PIK3CG, RELA, VDAC1, MYD88
5Measles2020.8PIK3CA, PIK3R1, PIK3CG, RELA, MYD88, CHUK
6IL-6 Pathway3620.5PIK3R1, PIM1, BMP1, BMP10, BMP6, BMP7
7all-trans-Retinoic Acid Signaling in Brain3619.9BMP1, BMP10, BMP6, BMP7, RARB, LIF
8Transendothelial Migration of Leukocytes3618.9PIK3R1, NCF2, VCAM1, VAV1, RASSF5, RAC1
9Chemokine signaling pathway2018.9PIK3CA, PIK3R1, PIK3CG, RELA, VAV1, RAF1
10Hepatitis C2018.6PIK3CA, PIK3R1, PIK3CG, RELA, RAF1, CHUK
11Endothelin-1 Signaling Pathway3618.5PIK3R1, MYC, BMP1, BMP10, BMP6, BMP7
12Toxoplasmosis2018.2PIK3CA, PIK3R1, PIK3CG, RELA, MYD88, BIRC3
13Phospholipase-C Pathway3617.6KITLG, VEGFC, BMP1, BMP10, BMP6, BMP7
14Phagosome2017.2NCF2, SFTPD, RAC1, CLEC7A, MRC1, MPO
15PKC-Theta Pathway3616.5PIK3R1, VAV1, RAC1, BCL10, CHUK, LAT
16TRAF Pathway3616.5PIK3R1, MYD88, BIRC3, CHUK, UBD, JUN
17TNF Superfamily Pathway3616.2PIK3R1, CHUK, JUN, FOS, FADD, MAPK8
18Intestinal immune network for IgA production2016.0CD28, CD86, CD40LG, CD80, CD40, IL10
19Staphylococcus aureus infection2015.7CFB, CFH, ITGAL, ITGB2, FPR1, FPR2
20ERK5 Signaling3615.2KITLG, VEGFC, MYC, BMP1, BMP10, BMP6
21Interferon Pathway3615.2PIK3R1, VAV1, RAC1, ATF4, JAK1, JAK2
22CTLA4 Signaling3615.1PIK3R1, CLTC, LAT, CD28, CD3D, CD86
23Immune response ICOS pathway in T-helper cell1015.1PIK3CA, PIK3R1, PIK3CG, RELA, VAV1, RAC1
24RIG-I-like receptor signaling pathway2015.0PIN1, RELA, CHUK, ISG15, IRF3, IL12A
25ITK and TCR Signaling3614.8PIK3R1, NCK1, NCK2, VAV1, RAC1, LAT
26Immune response_IFN alpha/beta signaling pathway4114.8USP18, JAK1, ISG15, IRF1, IRF2, IRF9
27Pancreatic Adenocarcinoma3614.8PIK3R1, KITLG, RB1, VEGFC, BMP1, BMP10
28TREM1 Pathway3614.8PIK3R1, MYD88, RAF1, BID, CHUK, BAD
29Immune response IFN alpha/beta signaling pathway1014.5USP18, JAK1, ISG15, IRF1, IRF2, IRF9
30IP3 Pathway3614.5PIK3R1, KITLG, VEGFC, VAV1, BMP1, BMP10
31Rac1 Pathway3614.4PIK3R1, NCF2, KITLG, BMP1, BMP10, BMP6
32PI3K Signaling in B-Lymphocyte3614.4PIK3R1, PIK3C2A, VAV1, RAF1, RAC1, BLNK
33Toll-Like Receptors Pathway3614.2PIK3R1, MYD88, RAC1, CHUK, ATF4, JUN
34CTL Mediated Apoptosis3614.2BID, CD3D, CD3G, CD3E, GZMB, FADD
3514-3-3 Induced Apoptosis3614.2PIK3R1, MYD88, BID, BCL2, CHUK, BAD
36Immune response_TLR signaling pathways4114.2RELA, MYD88, BECN1, CHUK, JUN, CD14
37IL-4 Pathway3614.2PIK3R1, RAF1, BCL2, BAD, JAK1, IRS1
38DHA Signaling3614.2PIK3R1, KITLG, VEGFC, BMP1, BMP10, BMP6
39Phagocytosis of Microbes3613.8PIK3R1, VTN, RAC1, MRC1, ITGAE, ITGAL
40Immune response CD28 signaling1013.8PIK3CA, PIK3R1, RELA, VAV1, RAC1, BCL2L1
41Malaria2013.7SELE, VCAM1, MYD88, CD36, CD81, CD40LG
42Immune response IL-12-induced IFN-gamma production1013.7RELA, CHUK, JUN, JAK2, CD3D, CD3G
43eIF2 Pathway3613.5PIK3R1, KITLG, VEGFC, BMP1, BMP10, BMP6
44Amoebiasis2013.5PIK3CA, PIK3R1, RELA, SERPINB3, SERPINB4, LAMC3
45Development_Prolactin receptor signaling4113.2PIK3CA, PIK3R1, RELA, VAV1, MYC, RAF1
46Paxillin Interactions3613.0PIK3R1, NCK1, KITLG, VEGFC, BMP1, BMP10
47Telomerase Components in Cell Signaling3612.8KITLG, RB1, VEGFC, MYC, BMP1, BMP10
48Immune response_IL-1 signaling pathway4112.8RELA, SERPINE1, MYD88, CHUK, JUN, FOS
49EGF Pathway3612.0PIK3R1, NCK1, NCK2, VAV1, MYC, RAF1
50Development_VEGF signaling via VEGFR2 - generic cascades4112.0PIK3CA, PIK3R1, NCK1, RELA, VEGFA, RAF1

Compounds for genes affiliated with Hepatitis B

Sources:
32Novoseek , 18HMDB, 9DrugBank, 42Tocris Bioscience, 34PharmGKB
See all sources

Compounds related to hepatitis b according to GeneDecks:

(show top 50)    (show all 446)
idCompoundScoreTop Affiliating Genes
1estrogen32 32.2PIK3R1, KLF6, NCOA6, RETN, PCNA, SERPINC1
2thymidine32 18 29.4PIK3CA, PIK3R1, CNTN2, KITLG, SFTPD, PCK2
3genistein32 9 18 9 27.8PIK3CA, PIK3R1, PIK3CG, KITLG, PCK2, PCNA
4progesterone32 42 9 18 9 26.9PIK3CA, PIK3R1, PCNA, RB1, SERPINA7, VEGFC
5butyrate32 22.8NCF2, KITLG, PCNA, RB1, VDR, MYC
6wortmannin32 42 23.1PIK3CA, PIK3R1, PIK3C2A, PIK3CG, KITLG, VTN
7pge232 21.9VTN, SELE, VIP, VCAM1, BMP7, RAF1
8arachidonic acid32 9 18 9 24.3PIK3CA, NCF2, KITLG, SERPINA1, VDAC1, VAV1
9polyacrylamide32 19.9RB1, SERPINA7, SERPINA1, RAD51, SAA4, S100A9
10arsenite32 18 19.1PIK3CA, PIK3R1, PIK3CG, CNTN2, PCNA, VEGFA
11ifn-alpha32 17.8LIF, MX1, JAK1, CDK2, CDKN2A, IRF1
12tamoxifen32 34 9 9 20.7PIK3CA, VTN, PCNA, SELE, SERPINC1, SERPINA7
13adenine32 9 18 9 20.7NAT1, NAT2, MYB, RAD51, SCGB1A1, LEP
14quercetin32 42 9 18 9 21.0PIK3CA, PIK3R1, PIK3C2A, PIK3CG, PIM1, SELE
15ccl332 16.8XCL1, MMP9, IL10, IL13, IL15, IL18
16prednisolone32 9 9 18.4PIK3C2A, KITLG, SFTPD, VIP, VCAM1, MYC
17okadaic acid32 42 17.3PIK3CA, PIK3R1, RELA, GCA, RB1, MYC
18il 1032 15.7VDR, BMP6, LIF, CD8A, CD40, IL10
19thapsigargin32 42 16.6PIK3CG, PCNA, SERPINE1, VIP, VCP, MYB
20gp 13032 15.2PIK3R1, PIM1, CNTFR, VIP, VAV1, BMP6
21malondialdehyde32 15.0PIK3C2A, MPO, GSR, GSTM1, GSTT1, FGA
22salicylic acid32 15.0PIK3CG, SERPINA7, SERPINA1, LPO, VDR, MYC
23ccl432 15.0S100B, XCL1, MET, IL12B, IL13, IL15
24leukotriene b432 42 18 16.9RAC1, LAP3, MPO, ITGAL, ITGB2, MMP9
25sialic acid32 14.8SERPINA7, LPO, S100B, CFH, CEACAM5, FUCA1
26lipoteichoic acid32 14.2SELE, BPI, MYD88, CD14, IL10, IL12B
27infliximab32 9 9 16.1SELE, VEGFA, BAK1, MMP1, MMP3, IL10
28hydroxyurea32 9 9 16.1KITLG, PCNA, VCAM1, MYC, MYCN, RAD51
29dmso32 14.0KITLG, BMP6, RAG2, UROD, S100A9, CD36
30gf 109203x32 42 15.0PIK3CG, KITLG, VEGFA, RAF1, JUN, JAK2
31pge132 13.8PIK3C2A, SERPINE1, VIP, B2M, AVPR2, CD40
32mannitol32 9 9 15.8VCAM1, BMP1, S100B, B2M, FTH1, JAK2
33egcg32 13.7PIK3CG, RAF1, BCL2L1, CHUK, CDK2, ITIH4
34threonine32 13.7SERPINA7, RAF1, CD4, IL1RAPL2, IL2RB, CCL11
35tunicamycin32 13.7PIK3CG, XBP1, ATF6, ATF4, CD4, CD44
36adpribose32 13.3PIK3CA, PIK3CG, PCNA, RB1, BID, BIRC5
372-chlorodeoxyadenosine32 13.0BIRC5, PARP1, BCL2, BAX, B2M, CD40LG
38vinblastine32 9 9 14.8RAF1, BIRC5, BCL2, BCL2L1, BAX, JUN
39progestin32 12.7PIK3R1, SERPINC1, VEGFA, LIF, CDH1, AR
40irinotecan32 34 9 9 15.7VEGFA, PARP1, BCL2L1, CHEK1, UGT1A7, BAK1
41cyclophosphamide32 34 9 9 15.6BCL6, MS4A1, ITGAL, ITGB2, APOH, MBL2
42suramin32 9 9 14.6PCNA, VIP, VEGFA, BMP6, RAF1, P2RX7
43erythromycin32 9 9 14.6PIK3C2A, VIP, VCAM1, BCL2L1, MSRA, MPO
44ivig32 12.5PIK3C2A, SAG, FCGR2B, FCGR3A, FCGRT, IL18R1
45inositol32 12.4KIR3DL1, CD79A, ITIH4, MBP, HSPA4, AKR1B1
46parthenolide32 12.1PIK3CG, BID, BIRC3, BCL2L1, CHUK, JAK2
47carbachol32 9 9 13.8CHRM1, MAPK10, F2RL1, HRH1, SST, CTSB
48losartan32 34 9 9 14.5PCNA, SELE, SERPINE1, VCAM1, BMP6, LEP
49noxa32 11.4BID, BIRC5, BCL2, BCL2L1, BAD, BAK1
50l-nmma32 11.1VIP, VCAM1, IL1RAP, IL1RN, IGHE, CAT

GO Terms for genes affiliated with Hepatitis B

Sources:
12Gene Ontology
See all sources

Cellular components related to hepatitis b according to GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588661.8PIK3R1, PIK3C2A, PIK3CG, PIM1, SH2B2, NCK1
2cytoplasmGO:00573759.3ZNF638, PIK3C2A, PIK3CG, PIN1, PIM1, SH2B2
3cytosolGO:00582944.5PIK3CA, PIK3R1, PIK3C2A, PIK3CG, SH2B2, SH2B3
4extracellular regionGO:00557643.6PDCD1LG2, RETN, KITLG, KIRREL3, VWCE, VTN
5extracellular spaceGO:00561540.4KITLG, VTN, SFTPC, SFTPD, BTD, SELE
6integral to plasma membraneGO:00588736.3LRMP, LRRC32, NCR1, NCR2, CNTN2, KIR2DS3
7nucleoplasmGO:00565425.7ZNF638, PIN1, NCOA6, RELA, PCNA, RB1
8external side of plasma membraneGO:00989720.6SERPINA5, VCAM1, CLEC7A, LAG3, P2RX7, B2M
9cell surfaceGO:00998617.8CNTN2, CNTNAP2, BST2, VEGFA, VCAM1, BMP10
10MHC class I protein complexGO:04261213.5RAET1E, RAET1L, ULBP1, ULBP2, ULBP3, B2M
11membrane raftGO:04512113.3SELE, BST2, BCL10, UMOD, LAT, P2RX7
12ER to Golgi transport vesicle membraneGO:01250713.3LMAN1, B2M, HLA-A, HLA-B, HLA-C, HLA-DPA1
13platelet alpha granule lumenGO:03109311.4SERPINA1, SERPINE1, SERPING1, VEGFA, VEGFC, MMRN1

Biological processes related to hepatitis b according to GeneDecks:

(show top 50)    (show all 76)
idNameGO IDScoreTop Affiliating Genes
1immune responseGO:00695537.1RFX1, PDCD1LG2, KIR2DS5, KIR2DL1, KIR2DL3, KIR3DS1
2signal transductionGO:00716533.5SH2B2, SH3BP2, NCK2, NCR1, NCR2, PDCD1
3innate immune responseGO:04508728.7PIK3CG, PIN1, NCF2, RELA, SFTPD, SERPING1
4inflammatory responseGO:00695428.1PIK3CG, RELA, SELE, MYD88, BMP6, RAC1
5cytokine-mediated signaling pathwayGO:01922125.3PIN1, SH2B2, KLF6, RELA, VCAM1, MYD88
6positive regulation of transcription from RNA polymerase II promoterGO:04594424.8KLF15, KLF6, RFX3, NCK1, NCK2, NCOA6
7apoptotic processGO:00691524.6PIM1, PDCD1, PDCD6IP, KIF1B, VDAC1, VAV1
8virus-host interactionGO:01904823.9PIK3R1, PDCD6IP, RELA, RB1, RBCK1, NACA
9positive regulation of transcription, DNA-dependentGO:04589322.6KLF6, RFX3, NCOA6, RELA, RB1, VHL
10response to virusGO:00961521.7BST2, MYD88, BECN1, URI1, CHUK, MX1
11cell surface receptor signaling pathwayGO:00716620.5BRD8, MYD88, LILRA1, LILRB5, LIFR, BIRC3
12cell-cell signalingGO:00726720.1BST2, NAMPT, S100A9, XCL1, CGB, CD33
13blood coagulationGO:00759619.8PIK3CA, PIK3R1, PIK3CG, SH2B2, SH2B3, SERPINC1
14cell adhesionGO:00715519.1CNTN2, CNTNAP2, KIRREL2, KITLG, VTN, SEMA4D
15chemotaxisGO:00693518.7CMKLR1, CMTM1, LECT2, S100A9, XCR1, FPR1
16type I interferon-mediated signaling pathwayGO:06033718.2USP18, MX1, MX2, XAF1, JAK1, ISG15
17negative regulation of cell proliferationGO:00828518.1NCK2, VHL, VDR, RARB, RAF1, LIF
18anti-apoptosisGO:00691618.0PIK3CA, RELA, SEMA4D, VHL, MYD88, BIRC3
19positive regulation of cell proliferationGO:00828418.0CNTFR, VIP, NAMPT, VEGFA, VEGFC, BNC1
20cell proliferationGO:00828317.6PIM1, KITLG, PCNA, BST2, NAB2, RAF1
21response to drugGO:04249317.4NCF2, SERPINA7, VEGFC, MYC, PARK7, BCL2
22regulation of immune responseGO:05077617.3KIR3DL2, KIR2DL1, KIR2DL3, KIR2DL4, KIR3DL1, KIR2DS2
23G-protein coupled receptor signaling pathwayGO:00718616.9PIK3CG, VIP, CMKLR1, CHRM1, XCR1, JAK2
24induction of apoptosisGO:00691716.5BCL10, BCL2L13, MX1, BAD, BAX, CEBPB
25positive regulation of I-kappaB kinase/NF-kappaB cascadeGO:04312316.4RELA, RBCK1, BST2, MYD88, BIRC3, BCL10
26interferon-gamma-mediated signaling pathwayGO:06033316.4VCAM1, CIITA, B2M, JAK1, JAK2, CD44
27negative regulation of apoptotic processGO:04306616.3PIK3CG, PIM1, RELA, SERPINE1, VEGFA, MYC
28defense response to virusGO:05160716.1RELA, BST2, BCL2, SAMHD1, CD86, CD207
29T cell costimulationGO:03129515.8PIK3CA, PIK3R1, PDCD1, PDCD1LG2, VAV1, RAC1
30cellular defense responseGO:00696815.6NCF2, NCR1, NCR2, RELA, KIR2DS3, KIR3DL2
31positive regulation of apoptotic processGO:04306515.6RARB, BID, BCL6, UBD, BAD, BAK1
32positive regulation of NF-kappaB transcription factor activityGO:05109215.3RELA, RBCK1, MYD88, BCL10, CHUK, CD40
33response to lipopolysaccharideGO:03249615.2NCF2, SFTPC, SELE, SERPINA1, S100A9, P2RX7
34cellular response to mechanical stimulusGO:07126015.2SFTPC, MYD88, BCL10, CHEK1, BAD, BAK1
35response to hypoxiaGO:00166615.1SERPINA1, VEGFA, VCAM1, RAF1, BCL2, LEP
36response to organic cyclic compoundGO:01407014.7NCF2, SERPINA1, LEF1, BAK1, P2RX7, JUN
37activation of cysteine-type endopeptidase activity involved in apoptotic processGO:00691914.5VCP, MYC, BCL2L13, BAD, BAX, JAK2
38acute-phase responseGO:00695314.2SERPINA1, SAA1, SAA2, SAA4, CEBPB, CEBPA
39T cell receptor signaling pathwayGO:05085214.0PIK3CA, PIK3R1, NCK1, RELA, RBCK1, BCL10
40response to glucocorticoid stimulusGO:05138413.9SFTPC, PCK2, SERPINE1, CEBPA, MSTN, IL10
41organ regenerationGO:03110013.7LIF, LIFR, LEF1, LCP1, BAK1, CEBPA
42platelet activationGO:03016813.7PIK3CA, PIK3R1, PIK3CG, SERPINA1, SERPINE1, SERPING1
43positive regulation of interleukin-6 productionGO:03275513.2MYD88, P2RX7, CD36, FIGF, FCER1G, IL1A
44positive regulation of T cell proliferationGO:04210213.2NCK1, NCK2, PDCD1LG2, VCAM1, CD28, CD1D
45positive regulation of interferon-gamma productionGO:03272913.1CD40LG, CD3E, IRF8, IL12A, IL12B, IL12RB1
46agingGO:00756813.0NCF2, SERPINA7, VDR, VCAM1, BAK1, MSRA
47positive regulation of inflammatory responseGO:05072912.8SERPINE1, JAK2, IL12B, IL15, IL18, IL1RL1
48activation of pro-apoptotic gene productsGO:00863312.6MYC, BID, BCL2, BAD, BAK1, BAX
49platelet degranulationGO:00257612.6SERPINA1, SERPINE1, SERPING1, VEGFA, VEGFC, CD36
50positive regulation of peptidyl-tyrosine phosphorylationGO:05073112.3KITLG, VTN, SEMA4D, VEGFA, LIF, JAK2

Molecular functions related to hepatitis b according to GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551577.7PIK3CA, PIK3R1, PIK3CG, PIN1, PIM1, SH3BP2
2cytokine activityGO:00512522.8KITLG, NAMPT, VEGFA, BMP1, BMP10, BMP6
3protein homodimerization activityGO:04280320.9NCOA6, SFTPC, GCA, BST2, VEGFA, RAG1
4receptor activityGO:00487219.4KIR2DL1, KIR2DL3, SEMA4D, SEMA4A, LILRA2, LILRB4
5receptor bindingGO:00510219.3NCK1, CNTFR, CNTNAP2, SEMA4D, SERPINE1, VCP
6carbohydrate bindingGO:03024618.0CNTN2, SFTPD, LMAN1L, CLC, CLEC2B, CLEC4G
7transmembrane signaling receptor activityGO:00488816.9NCR2, KIR2DL4, KIR2DS2, KIR2DS1, SELE, SEMA4D
8identical protein bindingGO:04280216.0RELA, CNTN2, PCNA, VCP, LMAN1, MYD88
9growth factor activityGO:00808315.3KITLG, VEGFA, VEGFC, BMP1, BMP10, BMP6
10chemokine activityGO:00800915.3CKLF, XCL1, IL8, CCL15, CCL7, CCL27
11transcription factor bindingGO:00813415.2PIM1, RELA, RB1, NAB2, VHL, MYC
12protein heterodimerization activityGO:04698215.1GCA, VEGFA, MYC, BMP6, RAF1, BIRC5
13transcription regulatory region DNA bindingGO:04421214.8RFX3, RELA, LEF1, CIITA, YY1, CEBPA
14enzyme bindingGO:01989914.4NCOA6, CNTNAP2, VHL, RAC1, BIRC5, BIRC7
15tumor necrosis factor receptor bindingGO:00516412.9CD40LG, FASLG, FADD, CASP8, TRAF2, TNF
16MHC class I receptor activityGO:03239312.8KIR3DS1, ULBP1, ULBP2, ULBP3, MR1, CD160

Sources for Hepatitis B

2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS