HBV
MCID: HPT016
MIFTS: 65

Hepatitis B (HBV) malady

Liver diseases category

Summaries for Hepatitis B

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Sources:
8Disease Ontology, 33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Your liver is the largest organ inside your body. it helps your body digest food, store energy, and remove poisons. hepatitis is an inflammation of the liver. one type, hepatitis b, is caused by the hepatitis b virus (hbv). hepatitis b spreads by contact with an infected person's blood, semen, or other body fluid. an infected woman can give hepatitis b to her baby at birth. if you get hbv, you may feel as if you have the flu. you may also have jaundice, a yellowing of skin and eyes, dark-colored urine, and pale bowel movements. some people have no symptoms at all. a blood test can tell if you have it. hbv usually gets better on its own after a few months. if it does not get better, it is called chronic hbv, which lasts a lifetime. chronic hbv can lead to scarring of the liver, liver failure, or liver cancer. there is a vaccine for hbv. it requires three shots. all babies should get the vaccine, but older children and adults can get it too. if you travel to countries where hepatitis b is common, you should get the vaccine. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Hepatitis B, also known as hepatitis b infection, is related to hepatitis and hepatocellular carcinoma, and has symptoms including jaundice, abdominal pain and loss of appetite. An important gene associated with Hepatitis B is RBCK1 (RanBP-type and C3HC4-type zinc finger containing 1), and among its related pathways is AHR Pathway. The drugs interferon alfa-2b and adefovir have been mentioned in the context of this disorder. Affiliated tissues include liver, liver and t cells.

Disease Ontology:8 A viral infectious disease that results in inflammation located in liver, has material basis in hepatitis b virus, which is transmitted by sexual contact, transmitted by blood transfusions, and transmitted by fomites like needles or syringes. the infection has symptom fever, has symptom fatigue, has symptom loss of appetite, has symptom nausea, has symptom vomiting, has symptom abdominal pain, has symptom clay-colored bowel movements, has symptom joint pain, and has symptom jaundice.

Wikipedia:63 Hepatitis B is an infectious illness of the liver caused by the hepatitis B virus (HBV) that affects... more...

Aliases & Classifications for Hepatitis B

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 38NCBI Bookshelf, 33MedlinePlus, 30LifeMap Discovery™, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Liver diseases


Aliases & Descriptions:

hepatitis b 8 10 44 33 30 60
hepatitis b infection 8
hepatitis b, chronic 60
hepatitis b chronic 44
chronic hepatitis b 8
hbv 38


External Ids:

Disease Ontology8 DOID:2043
MeSH34 D006509
NCIt39 C3097

Related Diseases for Hepatitis B

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Hepatitis B:



Diseases related to hepatitis b

Clinical Features for Hepatitis B

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Sources:
8Disease Ontology
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Symptoms:

8 (show all 9)
  • jaundice
  • abdominal pain
  • loss of appetite
  • nausea
  • fatigue
  • vomiting
  • clay-colored bowel movements
  • joint pain
  • fever

Drugs & Therapeutics for Hepatitis B

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Hepatitis B

Drug clinical trials:

Search ClinicalTrials for Hepatitis B

Search NIH Clinical Center for Hepatitis B

Search CenterWatch for Hepatitis B

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Hepatitis B cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Hepatitis B:
Bone marrow-derived mesenchymal stem cells for treatment of liver failure
Embryonic/Adult Cultured Cells Related to Hepatitis B:
Bone marrow-derived mesenchymal stem cells (family)

Genetic Tests for Hepatitis B

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Anatomical Context for Hepatitis B

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Hepatitis B:

32
Liver, T cells, B cells, Testes, Kidney, Skin, Eye, Bone, Monocytes, Thyroid, Nk cells, Endothelial, Myeloid, Bone marrow, Heart, Spinal cord, Breast, Colon, Salivary gland, Prostate, Pituitary, Pancreas, Lung, Lymph node, Brain

FMA organs/tissues related to Hepatitis B:

14
Liver

Animal Models for Hepatitis B or affiliated genes

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Publications for Hepatitis B

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Sources:
50PubMed
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Articles related to Hepatitis B:

(show top 50)    (show all 4108)
idTitleAuthorsYear
1
HBeAg-positive chronic hepatitis B: why do I treat my patients with pegylated interferon? (24373087)
2014
2
Hepatitis B virus complications of pregnancy after kidney transplantation. (24072142)
2013
3
Polymorphism of monocyte chemoattractant protein -1 (MCP-1 -2518 A/G) and responsiveness to hepatitis B vaccination in hemodialysis patients. (24382482)
2013
4
The association between hepatitis B virus infection and disease activity, synovitis, or joint destruction in rheumatoid arthritis. (23340833)
2013
5
Oral fluid and hepatitis A, B and C: a literature review. (22188507)
2012
6
HBcAg induces PD-1 upregulation on CD4+T cells through activation of JNK, ERK and PI3K/AKT pathways in chronic hepatitis-B-infected patients. (22042085)
2012
7
Superficial venous thrombophlebitis associated with pegylated interferon alpha-2a treatment in a patient with chronic hepatitis B. (23012682)
2012
8
Prevalence of viral hepatitis B and C in riverside communities of the TucuruA- Dam, ParA!, Brazil. (23080495)
2012
9
B cell activating factor (BAFF) in the natural history of chronic hepatitis C virus liver disease and mixed cryoglobulinaemia. (23039894)
2012
10
Association of serum soluble human leukocyte antigen-G levels with chronic hepatitis B virus infection. (23007926)
2012
11
Hepatitis B virus infection and pregnancy: a practical approach. (22528342)
2012
12
The X protein of hepatitis B virus activates hepatoma cell proliferation through repressing melanoma inhibitory activity 2 gene. (22120627)
2011
13
Hepatitis B virus infection from an evolutionary point of view: how viral, host, and environmental factors shape genotypes and subgenotypes. (21539937)
2011
14
Presence of HBV-DNA in cord blood is associated with spontaneous preterm birth in pregnant women with HBeAg-negative chronic hepatitis B virus infection. (21325782)
2011
15
The expression and role of Toll receptor 4 in renal tubular epithelial cells in hepatitis B virus infection]. (21781537)
2011
16
Efficacy and resistance of entecavir following 3 years of treatment of Japanese patients with lamivudine-refractory chronic hepatitis B. (20305760)
2010
17
Toll-like receptor polymorphisms are not associated with liver cirrhosis in hepatitis B virus infected Korean patients. (21443084)
2010
18
A comparative epidemiological study of hepatitis B and hepatitis D virus infections in Yanomami and Piaroa Amerindians of Amazonas State, Venezuela. (20561309)
2010
19
Side effects of long-term oral antiviral therapy for hepatitis B. (19399802)
2009
20
Association between CD4+CD25+Foxp3+ regulatory T cells and serum transforming growth factor beta 1 in patients with chronic hepatitis B]. (19958642)
2009
21
Safety and immunogenicity of diphtheria-tetanus-pertussis vaccine and hepatitis B vaccine as a new tetravalent combination (DTwP/HB) administered alone and at separate sites (DTwP and HB) including comparison with standard commercially available combination vaccine in Indian infants 6-14 weeks of age. (18849664)
2009
22
Calpain activation is required for homocysteine-mediated hepatic degradation of inhibitor I kappa B alpha. (19299176)
2009
23
Acute hepatitis B: is antiviral therapy indicated? Two case reports]. (18491273)
2008
24
Scavenger receptor class B type I mediates cell entry of hepatitis C virus. (19094442)
2008
25
Blockade of NKG2D on NKT cells prevents hepatitis and the acute immune response to hepatitis B virus. (17991774)
2007
26
Association between chronic hepatitis B virus infection and interleukin-10, tumor necrosis factor-alpha gene promoter polymorphisms. (16824070)
2006
27
Natural history of compensated cirrhosis in the Child-Pugh class A compared between 490 patients with hepatitis C and 167 with B virus infections. (16482557)
2006
28
High frequency of hepatocellular carcinoma in Mongolia; association with mono-, or co-infection with hepatitis C, B, and delta viruses. (17063518)
2006
29
The X protein of hepatitis B virus binds to the F box protein Skp2 and inhibits the ubiquitination and proteasomal degradation of c-Myc. (16376880)
2006
30
Investigation on correlation between expression of CD58 molecule and severity of hepatitis B. (16830383)
2006
31
High level of hepatitis B virus DNA after HBeAg-to-anti-HBe seroconversion is related to coexistence of mutations in its precore and basal core promoter. (15918203)
2005
32
Favorable efficacy of long-term lamivudine therapy in patients with chronic hepatitis B: an 8-year follow-up study. (15714490)
2005
33
A dose-ranging study of the efficacy and tolerability of entecavir in Lamivudine-refractory chronic hepatitis B patients. (16230074)
2005
34
Management of chronic hepatitis B with New Livfit in end stage renal disease. (15881863)
2005
35
The role of heat shock protein 27 expression in hepatocellular carcinoma in Japan: special reference to the difference between hepatitis B and C. (15287854)
2004
36
Association of HLA phenotype with primary non-response to recombinant hepatitis B vaccine: a study from north India. (15682656)
2004
37
Differential expression of perforin and granzyme B in the liver of patients with chronic hepatitis C. (14506637)
2003
38
Analysis of gene expression in hepatitis B virus transfected cell line induced by interferon. (14673494)
2003
39
Preliminary observation of CXCR3 expression on peripheral blood lymphocytes from patients with chronic hepatitis B infection]. (15163391)
2003
40
Virological response to interferon therapy of chronic hepatitis B as measured by a highly sensitive assay. (11555192)
2001
41
Epstein-Barr virus encoded nuclear protein EBNA-3 binds XAP-2, a protein associated with Hepatitis B virus X antigen. (10777214)
2000
42
Long-term follow-up of patients with anti-HBe/HBV DNA-positive chronic hepatitis B treated for 12 months with lamivudine. (10707871)
2000
43
Erythema multiforme following the exacerbation of hepatitis B virus infection. (10065611)
1999
44
No association between mannose-binding lectin alleles and susceptibility to chronic hepatitis B virus infection in German patients. (9813410)
1998
45
Changes in cytokine production during therapy with granulocyte-macrophage colony-stimulating factor in patients with chronic hepatitis B. (7927247)
1994
46
Cranial nerve palsy associated with acute hepatitis B. (8076978)
1994
47
Effects of alpha-interferon on gamma-interferon production of peripheral blood mononuclear cells in hepatitis B virus carriers. (1430105)
1992
48
A prospective study of post-transfusion non-A, non-B (type C) hepatitis following cardiovascular surgery in Taiwan. (1908889)
1991
49
Elevation of circulating immune complexes and its relationship to alpha-fetoprotein levels in patients with hepatitis B surface antigen-positive hepatocellular carcinoma. (1713804)
1991
50
A possible association between hepatitis-B antigen-negative infantile papular acrodermatitis and Epstein-Barr virus infection. (6284902)
1982

Genetic Variations for Hepatitis B

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Expression for genes affiliated with Hepatitis B

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hepatitis B

Search GEO for disease gene expression data for Hepatitis B.

Pathways for genes affiliated with Hepatitis B

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51QIAGEN
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Pathways related to Hepatitis B according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.9AHR, AIP

Compounds for genes affiliated with Hepatitis B

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GO Terms for genes affiliated with Hepatitis B

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Sources:
16Gene Ontology
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Biological processes related to Hepatitis B according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein polyubiquitinationGO:00020911.1RBCK1, PSMA7, PSMC1

Molecular functions related to Hepatitis B according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551513.3RFX1, SON, PSMC1, PSMA7, RBCK1, NR5A2
2DNA bindingGO:00367711.9RFX1, RARB, ILF2, AHR, NR5A2, RBCK1
3RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityGO:00370510.8NR5A2, AHR, RFX1
4asialoglycoprotein receptor activityGO:00487310.8ASGR2, ASGR1

Products for genes affiliated with Hepatitis B

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hepatitis B

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet