HBV
MCID: HPT016
MIFTS: 65

Hepatitis B (HBV) malady

Liver diseases category

Summaries for Hepatitis B

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Sources:
8Disease Ontology, 33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Your liver is the largest organ inside your body. it helps your body digest food, store energy, and remove poisons. hepatitis is an inflammation of the liver. one type, hepatitis b, is caused by the hepatitis b virus (hbv). hepatitis b spreads by contact with an infected person's blood, semen, or other body fluid. an infected woman can give hepatitis b to her baby at birth. if you get hbv, you may feel as if you have the flu. you may also have jaundice, a yellowing of skin and eyes, dark-colored urine, and pale bowel movements. some people have no symptoms at all. a blood test can tell if you have it. hbv usually gets better on its own after a few months. if it does not get better, it is called chronic hbv, which lasts a lifetime. chronic hbv can lead to scarring of the liver, liver failure, or liver cancer. there is a vaccine for hbv. it requires three shots. all babies should get the vaccine, but older children and adults can get it too. if you travel to countries where hepatitis b is common, you should get the vaccine. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Hepatitis B, also known as hepatitis b infection, is related to hepatitis and hepatocellular carcinoma, and has symptoms including fatigue, loss of appetite and nausea. An important gene associated with Hepatitis B is RBCK1 (RanBP-type and C3HC4-type zinc finger containing 1), and among its related pathways is AHR Pathway. The drugs adefovir and adefovir dipivoxil have been mentioned in the context of this disorder. Affiliated tissues include liver, liver and t cells.

Disease Ontology:8 A viral infectious disease that results in inflammation located in liver, has material basis in hepatitis b virus, which is transmitted by sexual contact, transmitted by blood transfusions, and transmitted by fomites like needles or syringes. the infection has symptom fever, has symptom fatigue, has symptom loss of appetite, has symptom nausea, has symptom vomiting, has symptom abdominal pain, has symptom clay-colored bowel movements, has symptom joint pain, and has symptom jaundice.

Wikipedia:63 Hepatitis B is an infectious illness of the liver caused by the hepatitis B virus (HBV) that affects... more...

Aliases & Classifications for Hepatitis B

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 38NCBI Bookshelf, 33MedlinePlus, 30LifeMap Discovery™, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Liver diseases


Aliases & Descriptions:

hepatitis b 8 10 44 33 30 60
hepatitis b infection 8
hepatitis b, chronic 60
hepatitis b chronic 44
chronic hepatitis b 8
hbv 38


External Ids:

Disease Ontology8 DOID:2043
MeSH34 D006509
NCIt39 C3097

Related Diseases for Hepatitis B

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Hepatitis B:



Diseases related to hepatitis b

Clinical Features for Hepatitis B

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Sources:
8Disease Ontology
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Symptoms:

8 (show all 9)
  • fatigue
  • loss of appetite
  • nausea
  • vomiting
  • abdominal pain
  • clay-colored bowel movements
  • joint pain
  • jaundice
  • fever

Drugs & Therapeutics for Hepatitis B

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Hepatitis B

Drug clinical trials:

Search ClinicalTrials for Hepatitis B

Search NIH Clinical Center for Hepatitis B

Search CenterWatch for Hepatitis B

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Hepatitis B cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Hepatitis B:
Bone marrow-derived mesenchymal stem cells for treatment of liver failure
Embryonic/Adult Cultured Cells Related to Hepatitis B:
Bone marrow-derived mesenchymal stem cells (family)

Genetic Tests for Hepatitis B

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Anatomical Context for Hepatitis B

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Hepatitis B:

32
Liver, T cells, B cells, Testes, Kidney, Skin, Eye, Bone, Monocytes, Thyroid, Nk cells, Endothelial, Myeloid, Bone marrow, Heart, Breast, Spinal cord, Salivary gland, Pituitary, Prostate, Pancreas, Lung, Colon, Brain, Lymph node

FMA organs/tissues related to Hepatitis B:

14
Liver

Animal Models for Hepatitis B or affiliated genes

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Publications for Hepatitis B

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Sources:
50PubMed
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Articles related to Hepatitis B:

(show top 50)    (show all 4108)
idTitleAuthorsYear
1
Cross-sectional and dynamic change of serum metabolite profiling for Hepatitis B-related acute-on-chronic liver failure by UPLC/MS. (24329857)
2014
2
Epidemiology and clinical features of childhood chronic hepatitis B infection diagnosed in England. (24418835)
2014
3
Downregulation of microRNA-15b by hepatitis B virus X enhances hepatocellular carcinoma proliferation via fucosyltransferase 2-induced Globo H expression. (24122375)
2014
4
Prevention of hepatitis B virus infection and liver cancer. (24008294)
2014
5
Prognostic value of chronic hepatitis B virus infection in patients with nasopharyngeal carcinoma: Analysis of 1301 patients from an endemic area in China. (24114075)
2014
6
Tim-3 expression on peripheral monocytes and CD3+CD16/CD56+natural killer-like T cells in patients with chronic hepatitis B. (24397461)
2014
7
Outreach Hepatitis B Vaccination of Female Sex Workers in Central-West Brazil: Immunization Status, Compliance, and Immune Response. (24378607)
2013
8
Hepatitis B virus vaccination in children with steroid sensitive nephrotic syndrome: immunogenicity and safety? (23684838)
2013
9
Latent hepatitis B is a risk factor for hepatocellular carcinoma in patients with chronic hepatitis C. (24409059)
2013
10
Hepatitis B virus X protein upregulates oncogene Rab18 to result in the dysregulation of lipogenesis and proliferation of hepatoma cells. (23471881)
2013
11
Low hepatitis B vaccine response in children with Down syndrome from Brazil. (23952481)
2013
12
Antiviral therapy delays esophageal variceal bleeding in hepatitis B virus-related cirrhosis. (24187460)
2013
13
Antiviral treatment improves disrupted peripheral B lymphocyte homeostasis in chronic hepatitis B virus-infected patients. (24085784)
2013
14
Hepatitis B virus infection and risk of lymphoma: results of a serological analysis within the European case-control study Epilymph. (22767316)
2012
15
Association of paraoxonase activity and atherosclerosis in patients with chronic hepatitis B. (23056015)
2012
16
Knowledge, attitude and practice of health care workers toward Hepatitis B virus infection, Sudan. (22751191)
2012
17
Functional Characterization of Interferon Regulation Element of Hepatitis B virus Genome In Vivo. (24293814)
2012
18
Nosocomial outbreak of hepatitis B virus infection involving two hospitals in the Republic of Ireland. (21530000)
2011
19
Hepatitis B viraemia: its heritability and association with common genetic variation in the interferon gamma signalling pathway. (20980339)
2011
20
+49G > A polymorphism in the cytotoxic T-lymphocyte antigen-4 gene increases susceptibility to hepatitis B-related hepatocellular carcinoma in a male Chinese population. (19778566)
2010
21
Expression of nuclear factor-I_B and its regulated cytokines in dendritic cells in patients with chronic severe hepatitis B and its clinical significance]. (20825713)
2010
22
Association between HLA-DQA1 gene polymorphism and the outcomes of hepatitis B virus infection]. (20718347)
2009
23
Combination of baseline parameters and on-treatment hepatitis B virus DNA levels to start and continue patients with lamivudine therapy. (19704171)
2009
24
Association of TBX21 T-1993C polymorphism with viral persistence but not disease progression in hepatitis B virus carriers. (19473434)
2009
25
In vitro effect of thymosin-alpha1 and interferon-alpha on Th1 and Th2 cytokine synthesis in patients with eAg-negative chronic hepatitis B. (18221304)
2008
26
A population-based, postlicensure evaluation of the safety of a combination diphtheria, tetanus, acellular pertussis, hepatitis B, and inactivated poliovirus vaccine in a large managed care organization. (19047220)
2008
27
Quantitative analysis of hepatitis D virus RNA and hepatitis B surface antigen serum levels in chronic delta hepatitis improves treatment monitoring. (17591028)
2007
28
Inhibition of alpha interferon signaling by hepatitis B virus. (17065208)
2007
29
Transduction of dendritic cells by recombinant adeno-associated virus (rAAV) carrying hepatitis B virus antigens]. (17653305)
2007
30
Patterns of viral decline during PEG-interferon alpha-2b therapy in HBeAg-positive chronic hepatitis B: relation to treatment response. (16941701)
2006
31
Diagnostic accuracy of serum biochemical fibrosis markers in children with chronic hepatitis B evaluated by receiver operating characteristics analysis. (16437671)
2005
32
Relationship between cytokine gene polymorphism and susceptibility to hepatitis B virus intrauterine infection]. (15941525)
2005
33
Treatment of hepatitis B and C co-infection in schizoaffective disorder. (16170206)
2005
34
Hemiballism with insular infarction as first manifestation of Takayasu's arteritis in association with chronic hepatitis B. (12574956)
2003
35
Th1-cytokines in chronic hepatitis B and C]. (12173430)
2002
36
Possible role of human interleukin-6 and soluble interleukin-6 receptor in hepatitis B virus infection. (11380796)
2001
37
Study on proinflammatory cytokines (IL-1 beta, IL-6, TNF-alpha) and IL-2 in patients with acute hepatitis B. (10462929)
1999
38
A hepatitis B virus mutant with a new hepatocyte nuclear factor 1 binding site emerging in transplant-transmitted fulminant hepatitis B. (9185776)
1997
39
Treatment of chronic viral hepatitis B with interferon alfa. Experience of the last 3 years]. (8625380)
1996
40
Differential pathways of insulin action upon the hepatitis B surface antigen gene expression and cell proliferation in human hepatoma cells. (7789317)
1995
41
Drug therapy in patients with chronic type B hepatitis]. (7549584)
1995
42
The role of oligomeric structure of human serum albumin during its interaction with polyalbumin receptors in blood serum of patients with viral hepatitis B]. (8511892)
1993
43
Treatment of chronic hepatitis B with interferon alpha-2b and interleukin-2. (8509640)
1993
44
Hepatitis B virus X protein activates transcription factor NF-kappa B without a requirement for protein kinase C. (1309924)
1992
45
Hepatic expression of type A and type B receptors for tumor necrosis factor. (1323602)
1992
46
Hepatitis B virus-associated membraneous nephropathy: clinical features, immunological profiles and outcome. (2191232)
1990
47
Acute hepatitis B and hepatitis D co-infection in the Stockholm region in the 1970s and 1980s--a comparison. (2076908)
1990
48
Hepatitis B-associated chronic inflammatory polyradiculoneuropathy. (2596466)
1989
49
Hepatitis D virus and human immunodeficiency virus antibodies in parenteral drug abusers who are hepatitis B surface antigen positive. (3171227)
1988
50
Membranous glomerulonephritis and hepatitis B virus infection. (6161316)
1980

Genetic Variations for Hepatitis B

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Expression for genes affiliated with Hepatitis B

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hepatitis B

Search GEO for disease gene expression data for Hepatitis B.

Pathways for genes affiliated with Hepatitis B

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51QIAGEN
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Pathways related to Hepatitis B according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.9AHR, AIP

Compounds for genes affiliated with Hepatitis B

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GO Terms for genes affiliated with Hepatitis B

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16Gene Ontology
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Biological processes related to Hepatitis B according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein polyubiquitinationGO:00020911.1RBCK1, PSMA7, PSMC1

Molecular functions related to Hepatitis B according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551513.3RFX1, SON, PSMC1, PSMA7, RBCK1, NR5A2
2DNA bindingGO:00367711.9RFX1, RARB, ILF2, AHR, NR5A2, RBCK1
3RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityGO:00370510.8NR5A2, AHR, RFX1
4asialoglycoprotein receptor activityGO:00487310.8ASGR2, ASGR1

Products for genes affiliated with Hepatitis B

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hepatitis B

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet