HBV
MCID: HPT016
MIFTS: 68

Hepatitis B (HBV) malady

Infectious diseases, Gastrointestinal diseases, Liver diseases, Rare diseases, Immune diseases categories

Summaries for Hepatitis B

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Sources:
9Disease Ontology, 35MedlinePlus, 66Wikipedia, 34MalaCards
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MedlinePlus:35 Your liver is the largest organ inside your body. it helps your body digest food, store energy, and remove poisons. hepatitis is an inflammation of the liver. one type, hepatitis b, is caused by the hepatitis b virus (hbv). hepatitis b spreads by contact with an infected person's blood, semen, or other body fluid. an infected woman can give hepatitis b to her baby at birth. if you get hbv, you may feel as if you have the flu. you may also have jaundice, a yellowing of skin and eyes, dark-colored urine, and pale bowel movements. some people have no symptoms at all. a blood test can tell if you have it. hbv usually gets better on its own after a few months. if it does not get better, it is called chronic hbv, which lasts a lifetime. chronic hbv can lead to scarring of the liver, liver failure, or liver cancer. there is a vaccine for hbv. it requires three shots. all babies should get the vaccine, but older children and adults can get it too. if you travel to countries where hepatitis b is common, you should get the vaccine. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Hepatitis B, also known as hepatitis b infection, is related to hepatitis and hepatocellular carcinoma, and has symptoms including fatigue, loss of appetite and nausea. An important gene associated with Hepatitis B is RARB (retinoic acid receptor, beta), and among its related pathways are AHR Pathway and AHR Pathway. The drugs adefovir and adefovir dipivoxil have been mentioned in the context of this disorder. Affiliated tissues include liver, liver and t cells, and related mouse phenotypes are liver/biliary system and mortality/aging.

Disease Ontology:9 A viral infectious disease that results in inflammation located in liver, has material basis in hepatitis b virus, which is transmitted by sexual contact, transmitted by blood transfusions, and transmitted by fomites like needles or syringes. the infection has symptom fever, has symptom fatigue, has symptom loss of appetite, has symptom nausea, has symptom vomiting, has symptom abdominal pain, has symptom clay-colored bowel movements, has symptom joint pain, and has symptom jaundice.

Wikipedia:66 Hepatitis B is an infectious illness of the liver caused by the hepatitis B virus (HBV) that affects... more...

Aliases & Classifications for Hepatitis B

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Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 35MedlinePlus, 32LifeMap Discoveryā„¢, 63UMLS, 40NCBI Bookshelf, 59SNOMED-CT, 36MeSH, 41NCIt
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Classifications:



Aliases & Descriptions:

hepatitis b 9 11 46 35 32 63
hepatitis b infection 9
hepatitis b, chronic 63
hepatitis b chronic 46
chronic hepatitis b 9
hbv 40


External Ids:

Disease Ontology9 DOID:2043
MeSH36 D006509
NCIt41 C3097

Related Diseases for Hepatitis B

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Hepatitis B:



Diseases related to hepatitis b

Symptoms for Hepatitis B

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Sources:
9Disease Ontology
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Symptoms:

9 (show all 9)
  • fatigue
  • loss of appetite
  • nausea
  • vomiting
  • abdominal pain
  • clay-colored bowel movements
  • joint pain
  • jaundice
  • fever

Drugs & Therapeutics for Hepatitis B

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 32LifeMap Discoveryā„¢, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Hepatitis B

Drug clinical trials:

Search ClinicalTrials for Hepatitis B

Search NIH Clinical Center for Hepatitis B

Search CenterWatch for Hepatitis B

Inferred drug relations via UMLS63/NDF-RT42:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Hepatitis B cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Hepatitis B:
Bone marrow-derived mesenchymal stem cells for treatment of liver failure
Embryonic/Adult Cultured Cells Related to Hepatitis B:
Bone marrow-derived mesenchymal stem cells (family)

Genetic Tests for Hepatitis B

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Anatomical Context for Hepatitis B

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Sources:
34MalaCards, 15FMA
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MalaCards organs/tissues related to Hepatitis B:

34
Liver, T cells, Testes, Kidney, Skin, Eye, Bone, B cells, Monocytes, Thyroid, Endothelial, Myeloid, Nk cells, Bone marrow, Breast, Heart, Spinal cord, Prostate, Lymph node, Pituitary, Brain

FMA organs/tissues related to Hepatitis B:

15
Liver

Animal Models for Hepatitis B or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Hepatitis B:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053709.9RBCK1, NR5A2, ASGR1, AHR, AIP
2MP:00107689.0RARB, AIP, AHR, RFX1, ASGR2, ASGR1

Publications for Hepatitis B

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Sources:
53PubMed
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Articles related to Hepatitis B:

(show top 50)    (show all 3717)
idTitleAuthorsYear
1
HBeAg-positive chronic hepatitis B: why do I treat my patients with pegylated interferon? (24373087)
2014
2
Reply to: Mother-to-infant transmission of hepatitis B virus infection: significance of maternal viral load and strategies for intervention. (23665186)
2013
3
Purification of hepatitis B surface antigen virus-like particles from recombinant Pichia pastoris and in vivo analysis of their immunogenic properties. (24141044)
2013
4
IL28B polymorphisms predict interferon-related hepatitis B surface antigen seroclearance in genotype D hepatitis B e antigen-negative patients with chronic hepatitis B. (22473858)
2013
5
Association of cytokine and cytokine receptor gene polymorphisms with the risk of chronic hepatitis B. (24383970)
2013
6
IL-17A but not IL-22 suppresses the replication of hepatitis B virus mediated by over-expression of MxA and OAS mRNA in the HepG2.2.15 cell line. (23274784)
2013
7
Hepatitis B virus X protein protects hepatoma and hepatic cells from complement-dependent cytotoxicity by up-regulation of CD46. (23391762)
2013
8
Hodgkin's lymphoma coexisting with liver failure secondary to acute on chronic hepatitis B. (24303460)
2013
9
Combined hexavalent diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliovirus-Hemophilus influenzae type b vaccine; Infanrixa8c hexa: Twelve years of experience in Italy. (24004825)
2013
10
Hepatitis B virus infection and fatty liver in the general population. (22027575)
2012
11
Relationships between tumour necrosis factor-I+, interleukin-12B and interleukin-10 gene polymorphisms and hepatitis B in Chinese Han haemodialysis patients. (22070668)
2012
12
Multiple outbreaks of hepatitis B virus infection related to assisted monitoring of blood glucose among residents of assisted living facilities--Virginia, 2009-2011. (22592272)
2012
13
Loss of microRNA 122 expression in patients with hepatitis B enhances hepatitis B virus replication through cyclin G(1) -modulated P53 activity. (22105316)
2012
14
Prevalence of hepatitis B virus infection in a highly endemic area of southern China after catch-up immunization. (22499009)
2012
15
A zebrafish model of intrahepatic cholangiocarcinoma by dual expression of hepatitis B virus X and hepatitis C virus core protein in liver. (22729936)
2012
16
The association of hepatitis B virus infection with B-cell non-Hodgkin lymphoma - a review. (22432084)
2012
17
Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus. (23150796)
2012
18
IL28B rs12979860 polymorphism does not influence outcomes of hepatitis B virus infection. (22239156)
2012
19
Multiple cerebral arterial stenosis associated with hepatitis B virus infection. (21519526)
2011
20
The Seroconversion Rate of Hepatitis A Virus Vaccination among Patients with Hepatitis B Virus-Related Chronic Liver Disease in Korea. (21814604)
2011
21
Natural history of hepatitis B virus infection: pediatric perspective. (20812021)
2011
22
Hepatitis C and hepatitis B virus infection: epidemiology and risk factors in a large cohort of pregnant women in Lorestan, West of Iran. (22235217)
2011
23
Efficacy and resistance of entecavir following 3 years of treatment of Japanese patients with lamivudine-refractory chronic hepatitis B. (20305760)
2010
24
HBs seroconversion in a patient with acute hepatitis B treated with entecavir during immunosuppression against severe bronchiolitis obliterans in the course of chronic graft versus host disease. (20403727)
2010
25
Role of serum prothrombin induced by vitamin K absence or antagonist-II in the early detection of hepatocellular carcinoma in patients with chronic hepatitis B virus infection. (19391065)
2009
26
Abnormal liver function test results are related to metabolic syndrome and BMI in Taiwanese adults without chronic hepatitis B or C. (19752878)
2009
27
The change of intestinal mucosa barrier in chronic severe hepatitis B patients and clinical intervention]. (19874691)
2009
28
The influences of camel milk on the immune response of chronic hepatitis B patients]. (19426601)
2009
29
Bell's palsy as a possible complication of hepatitis B vaccination in a child. (19902808)
2009
30
HLA-A *3303* and *3301 predispose patients to persistent hepatitis B infection. (19337647)
2009
31
Expression of IFN-alpha/beta receptor in the PBMCs and liver of patients with hepatitis B and its clinical significance]. (18583243)
2008
32
HLA and response to booster hepatitis B vaccination in anti-HBs-seronegative adolescents who had received primary infantile vaccination. (18501999)
2008
33
Hepatitis B virus X protein and the estrogen receptor variant lacking exon 5 inhibit estrogen receptor signaling in hepatoma cells. (16757575)
2006
34
Serum fibrosis markers as predictors of an antifibrotic effect of interferon alfa in children with chronic hepatitis B. (16003134)
2005
35
Interferon-gamma inhibits hepatitis B virus-induced NF-kappaB activation through nuclear localization of NF-kappaB-inducing kinase. (15940636)
2005
36
IFN or oxymatrine in combination with lamivudine in patients with lamivudine-resistant chronic hepatitis B]. (15340535)
2004
37
Expression of Fas antigen in liver tissue of patients with chronic hepatitis B and C. (15195900)
2004
38
Markers of disease activity in chronic hepatitis B virus infection. (12659467)
2003
39
Relationship of interleukin-1B and interleukin-1 receptor antagonist gene polymorphisms with chronic hepatitis B]. (14669220)
2003
40
Hepatitis B virus X protein associated with UV-DDB1 induces cell death in the nucleus and is functionally antagonized by UV-DDB2. (12151405)
2002
41
Lack of a role of the interferon-stimulated response element-like region in interferon alpha -induced suppression of Hepatitis B virus in vitro. (11106638)
2001
42
Apoptosis in viral hepatitis B and C. (11480324)
2001
43
Hepatitis B virus large envelope protein interacts with gamma2- adaptin, a clathrin adaptor-related protein. (11333915)
2001
44
Epstein-Barr virus encoded nuclear protein EBNA-3 binds XAP-2, a protein associated with Hepatitis B virus X antigen. (10777214)
2000
45
The use of deferoxamine infusions to enhance the response rate to interferon-alpha treatment of chronic viral hepatitis B. (8871871)
1996
46
Comparison of clinico-pathological features in hepatitis B virus-associated hepatocellular carcinoma with or without hepatitis D virus superinfection. (8912142)
1996
47
Reactivity to hepatitis B vaccination (HBV) in patients with uremia: association with defined HLA antigen configuration and complement protein allotypes C4A, C4B and B factor (Bf)]. (8834646)
1995
48
Minor role of hepatitis B virus in the causation of chronic liver disease in Somalia indicated by a case-control study. (1712517)
1991
49
alpha-Interferon therapy in patients with chronic active hepatitis B: immunological profile. (1669591)
1991
50
Hepatitis B e antigen-mediated membranous glomerulonephritis. Correlation of ultrastructural changes with HBeAg in the serum and glomeruli. (7464047)
1981

Variations for Hepatitis B

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Expression for genes affiliated with Hepatitis B

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hepatitis B

Search GEO for disease gene expression data for Hepatitis B.

Pathways for genes affiliated with Hepatitis B

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51PathCards, 54QIAGEN, 39NCBI BioSystems Database
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Pathways related to Hepatitis B according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
AhR pathway39
10.3AHR, AIP
210.3AHR, AIP

Compounds for genes affiliated with Hepatitis B

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GO Terms for genes affiliated with Hepatitis B

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17Gene Ontology
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Cellular components related to Hepatitis B according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:0056549.8RARB, NR5A2, PSMA7, PSMC1, RSF1
2nucleusGO:0056348.9RARB, AIP, RSF1, AHR, SON, RFX1

Biological processes related to Hepatitis B according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intracellular receptor signaling pathwayGO:03052210.2NR5A2, AHR
2protein polyubiquitinationGO:00020910.0RBCK1, PSMA7, PSMC1
3negative regulation of apoptotic processGO:0430669.7PSMA7, PSMC1, SON, LAMTOR5

Molecular functions related to Hepatitis B according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1asialoglycoprotein receptor activityGO:00487310.3ASGR1, ASGR2
2RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityGO:00370510.1NR5A2, RFX1, AHR
3ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityGO:0048799.9NR5A2, AHR
4zinc ion bindingGO:0082709.9RBCK1, RARB, NR5A2, CPD, RSF1
5DNA bindingGO:0036779.6RARB, NR5A2, ILF2, RFX1, SON, AHR
6protein bindingGO:0055158.9ILF2, PSMA7, ASGR1, NR5A2, RARB, RBCK1

Products for genes affiliated with Hepatitis B

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hepatitis B

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet