HBV
MCID: HPT016
MIFTS: 62

Hepatitis B (HBV) malady

Liver category

Summaries for Hepatitis B

Sources:
8Disease Ontology, 34MedlinePlus, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Your liver is the largest organ inside your body. it helps your body digest food, store energy, and remove poisons. hepatitis is an inflammation of the liver. one type, hepatitis b, is caused by the hepatitis b virus (hbv). hepatitis b spreads by contact with an infected person's blood, semen, or other body fluid. an infected woman can give hepatitis b to her baby at birth. if you get hbv, you may feel as if you have the flu. you may also have jaundice, a yellowing of skin and eyes, dark-colored urine, and pale bowel movements. some people have no symptoms at all. a blood test can tell if you have it. hbv usually gets better on its own after a few months. if it does not get better, it is called chronic hbv, which lasts a lifetime. chronic hbv can lead to scarring of the liver, liver failure, or liver cancer. there is a vaccine for hbv. it requires three shots. all babies should get the vaccine, but older children and adults can get it too. if you travel to countries where hepatitis b is common, you should get the vaccine. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Hepatitis B, also known as hepatitis b infection, is related to hepatitis c and hepatitis a, and has symptoms including fever, jaundice and abdominal pain. An important gene associated with Hepatitis B is RBCK1 (RanBP-type and C3HC4-type zinc finger containing 1), and among its related pathways is AHR Pathway. The drugs adefovir and adefovir dipivoxil have been mentioned in the context of this disorder. Affiliated tissues include liver, skin and liver.

Disease Ontology:8 A viral infectious disease that results in inflammation located in liver, has material basis in hepatitis b virus, which is transmitted by sexual contact, transmitted by blood transfusions, and transmitted by fomites like needles or syringes. the infection has symptom fever, has symptom fatigue, has symptom loss of appetite, has symptom nausea, has symptom vomiting, has symptom abdominal pain, has symptom clay-colored bowel movements, has symptom joint pain, and has symptom jaundice.

Wikipedia:64 Hepatitis B is an infectious illness of the liver caused by the hepatitis B virus (HBV) that affects... more...

Aliases & Classifications for Hepatitis B

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 34MedlinePlus, 31LifeMap Discovery™, 61UMLS, 39NCBI Bookshelf, 57SNOMED-CT, 35MeSH, 40NCIt
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Liver


Aliases & Descriptions:

hepatitis b 8 10 45 34 31 61
hepatitis b infection 8
hepatitis b, chronic 61
hepatitis b chronic 45
chronic hepatitis b 8
hbv 39


External Ids:

Disease Ontology8 DOID:2043
MeSH35 D006509
NCIt40 C3097

Related Diseases for Hepatitis B

Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Hepatitis B:



Diseases related to hepatitis b

Clinical Features for Hepatitis B

Sources:
8Disease Ontology
See all sources


Symptoms:

8 (show all 9)
  • fever
  • jaundice
  • abdominal pain
  • loss of appetite
  • nausea
  • fatigue
  • vomiting
  • clay-colored bowel movements
  • joint pain

Drugs & Therapeutics for Hepatitis B

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Hepatitis B

Drug clinical trials:

Search ClinicalTrials for Hepatitis B

Search NIH Clinical Center for Hepatitis B

Search CenterWatch for Hepatitis B

Inferred drug relations via UMLS61/NDF-RT41:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Hepatitis B cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Hepatitis B:
Bone marrow-derived mesenchymal stem cells for treatment of liver failure
Embryonic/Adult Cultured Cells Related to Hepatitis B:
Bone marrow-derived mesenchymal stem cells (family)

Genetic Tests for Hepatitis B

Anatomical Context for Hepatitis B

Sources:
33MalaCards, 14FMA
See all sources

MalaCards organs/tissues related to Hepatitis B:

33
Skin, Liver, Spinal cord, Brain, Kidney, Bone marrow, Whole blood, Heart, Smooth muscle, Small intestine, Pancreas, Thyroid, Breast, Prostate, Monocytes, Nk cells, T cells, B cells, Endothelial, Fetal brain, Fetal liver, Fetal thyroid, Pituitary

FMA organs/tissues related to Hepatitis B:

14
Liver

Animal Models for Hepatitis B or affiliated genes

Sources:
28inGenious Targeting Laboratory
See all sources

Publications for Hepatitis B

Sources:
51PubMed
See all sources

Articles related to Hepatitis B:

(show top 50)    (show all 1973)
idTitleAuthorsYear
1
Prophylactic effect of lamivudine-based antiretroviral therapy on incident hepatitis B virus infection among HIV-infected patients. (23926178)
2013
2
The prevalence of hepatitis B virus infection in mashhad, iran: a population-based study. (23984006)
2013
3
Zoonotic hepatitis E virus strains in German blood donors. (22913247)
2013
4
Pathogenesis of viruses-associated human cancers: Epstein-Barr virus and hepatitis B virus as two examples. (24095032)
2013
5
The X-ray repair cross complementing protein 1 (XRCC1) rs25487 polymorphism and susceptibility to cirrhosis in Brazilian patients with chronic viral hepatitis. (24018491)
2013
6
Boceprevir Plus Peginterferon I+-2b/Ribavirin in Chronic Hepatitis C Genotype 1: Impact of Baseline Viral Load on Sustained Virologic Response. (24177376)
2013
7
Prevalence of hepatitis A antibodies in Eastern Bolivia: a population-based study. (23861034)
2013
8
Baseline characteristics and mortality among people in care for chronic viral hepatitis: the chronic hepatitis cohort study. (22990852)
2013
9
Occult hepatitis B virus infection in hemodialysis patients in Recife, State of Pernambuco, Brazil. (23152336)
2012
10
Three cases of acute or fulminant hepatitis E caused by ingestion of pork meat and entrails in Hokkaido, Japan: Zoonotic food-borne transmission of hepatitis E virus and public health concerns. (22568494)
2012
11
Ultrasound-guided interscalene brachial plexus block in a pediatric patient with acute hepatitis -A case report-. (22778895)
2012
12
A Case of Drug-Induced Hepatitis due to Bortezomib in Multiple Myeloma. (22916049)
2012
13
Knowledge, attitudes and barriers regarding vaccination against hepatitis A and B in patients with chronic hepatitis C virus infection: a survey of family medicine and internal medicine physicians in the United States. (22994334)
2012
14
Theoretical basis of a beneficial role for vitamin D in viral hepatitis. (23082050)
2012
15
Follow-up and indications for liver biopsy in HBeAg-negative chronic hepatitis B virus infection with persistently normal ALT: a systematic review. (22450396)
2012
16
MEMS biosensor for detection of Hepatitis A and C viruses in serum. (21803562)
2011
17
Arsenic, vinyl chloride, viral hepatitis, and hepatic angiosarcoma: a hospital-based study and review of literature in Taiwan. (22200164)
2011
18
Role of peroxisome proliferator-activated receptor gamma coactivator 1alpha in AKT/PKB-mediated inhibition of hepatitis B virus biosynthesis. (21880746)
2011
19
Genetic variations of bile salt transporters as predisposing factors for drug-induced cholestasis, intrahepatic cholestasis of pregnancy and therapeutic response of viral hepatitis. (21320040)
2011
20
The ORF3 protein of hepatitis E virus delays degradation of activated growth factor receptors by interacting with CIN85 and blocking formation of the Cbl-CIN85 complex. (20130058)
2010
21
Association of hepatitis C virus infection and liver fibrosis severity with the variants alleles of MBL2 gene in a Brazilian population. (20570631)
2010
22
Recurrence of autoimmune disease, primary sclerosing cholangitis, primary biliary cirrhosis, and autoimmune hepatitis after liver transplantation. (19876939)
2009
23
Bell's palsy as a possible complication of hepatitis B vaccination in a child. (19902808)
2009
24
Imported typhoid fever with hepatitis from Bangladesh: a case of delayed response to ceftriaxone? (19006514)
2008
25
Interferon-induced prolonged biochemical response reduces hepatocarcinogenesis in hepatitis C virus infection. (17705189)
2007
26
Overexpressed cyclo-oxygenase-2 in the background liver is associated with the clinical course of hepatitis C virus-related cirrhosis patients after curative surgery for hepatocellular carcinoma. (17688665)
2007
27
Changes of Toll-like receptor (TLR) 2 and TLR4 on the peripheral blood mononuclear cells in patients with chronic hepatitis B and chronic severe hepatitis B]. (17524268)
2007
28
Immunogenicity and safety of a tetravalent measles-mumps-rubella-varicella vaccine co-administered with a booster dose of a combined diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliovirus-Haemophilus influenzae type b conjugate vaccine in healthy children aged 12-23 months. (17541639)
2007
29
S-Adenosylmethionine and betaine correct hepatitis C virus induced inhibition of interferon signaling in vitro. (16557551)
2006
30
Screening of hepatocyte proteins binding to F protein of hepatitis C virus by yeast two-hybrid system. (16237761)
2005
31
Acute esophageal necrosis associated with alcoholic hepatitis: is it black or is it white? (15731944)
2005
32
Hepatitis C virus NS5A-mediated activation of phosphoinositide 3-kinase results in stabilization of cellular beta-catenin and stimulation of beta-catenin-responsive transcription. (15795286)
2005
33
Severe exacerbation of chronic hepatitis B during therapy with corticosteroids and lamivudine therapy and successful short-term combination therapy with interferon-beta and interferon-gamma]. (12772056)
2003
34
Serum biomarkers of hepatitis B virus infected liver inflammation: a proteomic study. (12748946)
2003
35
Incidence and estimated rates of residual risk for HIV, hepatitis C, hepatitis B and human T-cell lymphotropic viruses in blood donors in Canada, 1990-2000. (14557314)
2003
36
Simple blood tests can predict compensated liver cirrhosis in patients with chronic hepatitis C. (11995477)
2002
37
A short sequence within domain C of duck carboxypeptidase D is critical for duck hepatitis B virus binding and determines host specificity. (11602705)
2001
38
Distribution of hepatitis C virus infection in liver biopsies from children and adults with chronic hepatitis C. (11285561)
2001
39
Soluble thrombomodulin is associated with viral hepatitis, blood pressure, and medications in haemodialysis patients. (11274275)
2001
40
Pretreatment expression of the perforin gene by circulating CD8(+) T lymphocytes predicts biochemical response to interferon-alpha in patients with chronic hepatitis C. (10903796)
2000
41
The impact of interferon plus ribavirin on response to therapy in black patients with chronic hepatitis C. The International Hepatitis Interventional Therapy Group. (11054390)
2000
42
Binding of hepatitis C virus E2 glycoprotein to CD81 does not correlate with species permissiveness to infection. (10846074)
2000
43
Hepatitis C virus infection and bone marrow transplantation: a cohort study with 10-year follow-up. (10347135)
1999
44
Serum levels of soluble interferon Alfa/Beta receptor as an inhibitory factor of interferon in the patients with chronic hepatitis C. (10534358)
1999
45
Relation between serum hepatitis C virus-RNA levels and efficacy of interferon-beta therapy. (7572160)
1995
46
The association of hepatitis C virus infection with monoclonal rheumatoid factors bearing the WA cross-idiotype: implications for the etiopathogenesis and therapy of mixed cryoglobulinemia. (8730487)
1995
47
Genome detection in liver and peripheral blood mononuclear cells: predictor factors of sustained response in patients with chronic hepatitis C. (8574725)
1995
48
Interleukin 6 production by peripheral blood mononuclear cells in patients with chronic hepatitis B virus infection and primary biliary cirrhosis. (8440420)
1993
49
Ursodiol in the long-term treatment of chronic hepatitis: a double-blind multicenter clinical trial. (8151107)
1993
50
Recombinant human gamma-interferon in patients with chronic active hepatitis B: pharmacokinetics, tolerance and biological effects. (2115494)
1990

Genetic Variations for Hepatitis B

Expression for genes affiliated with Hepatitis B

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Hepatitis B

Search GEO for disease gene expression data for Hepatitis B.

Pathways for genes affiliated with Hepatitis B

Sources:
52QIAGEN
See all sources

Pathways related to Hepatitis B according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.9AHR, AIP

Compounds for genes affiliated with Hepatitis B

GO Terms for genes affiliated with Hepatitis B

Sources:
16Gene Ontology
See all sources

Biological processes related to Hepatitis B according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein polyubiquitinationGO:00020911.1RBCK1, PSMA7, PSMC1

Molecular functions related to Hepatitis B according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551513.3RFX1, SON, PSMC1, PSMA7, RBCK1, NR5A2
2DNA bindingGO:00367711.9RFX1, RARB, ILF2, AHR, NR5A2, RBCK1
3RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityGO:00370510.8NR5A2, AHR, RFX1
4asialoglycoprotein receptor activityGO:00487310.8ASGR2, ASGR1

Products for genes affiliated with Hepatitis B

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hepatitis B

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet