NANBH
MCID: HPT001
MIFTS: 66

Hepatitis C (NANBH) malady

Infectious diseases, Liver diseases, Gastrointestinal diseases, Rare diseases, Immune diseases categories

Summaries for Hepatitis C

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Sources:
9Disease Ontology, 35MedlinePlus, 66Wikipedia, 34MalaCards
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MedlinePlus:35 Your liver is the largest organ inside your body. it helps your body digest food, store energy, and remove poisons. hepatitis is an inflammation of the liver. one type, hepatitis c, is caused by the hepatitis c virus (hcv). it usually spreads through contact with infected blood. it can also spread through sex with an infected person and from mother to baby during childbirth. most people who are infected with hepatitis c don't have any symptoms for years. if you do get symptoms, you may feel as if you have the flu. you may also have jaundice, a yellowing of skin and eyes, dark-colored urine, and pale bowel movements. a blood test can tell if you have it. usually, hepatitis c does not get better by itself. the infection can last a lifetime and may lead to scarring of the liver or liver cancer. medicines sometimes help, but side effects can be a problem. serious cases may need a liver transplant. there is no vaccine for hcv. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Hepatitis C, also known as hepatitis c infection, is related to hepatitis and hepatitis c virus, and has symptoms including jaundice, fever and fatigue. An important gene associated with Hepatitis C is ACY3 (aspartoacylase (aminocyclase) 3), and among its related pathways is Hepatitis C. The drugs hepatitis c virus ns3/4a protease inhibitor [epc] and interferon alfa-2a have been mentioned in the context of this disorder. Affiliated tissues include liver, liver and t cells.

Disease Ontology:9 A viral infectious disease that results in inflammation located in liver, has material basis in hepatitis c virus, which is transmitted by blood from an infected person enters the body of an uninfected person. the infection has symptom fever, has symptom fatigue, has symptom loss of appetite, has symptom nausea, has symptom vomiting, has symptom abdominal pain, has symptom clay-colored bowel movements, has symptom joint pain, and has symptom jaundice.

Wikipedia:66 Hepatitis C is an infectious disease affecting primarily the liver, caused by the hepatitis C virus... more...

Aliases & Classifications for Hepatitis C

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Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 35MedlinePlus, 63UMLS, 41NCIt, 36MeSH, 28ICD9CM, 59SNOMED-CT
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Classifications:



Aliases & Descriptions:

hepatitis c 9 11 46 35 63
hepatitis c infection 9
hepatitis c, chronic 63
chronic hepatitis c 9
hepatitis nona nonb 9
hepatitis c chronic 46
viral hepatitis c 9
nanbh 9


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Disease Ontology9 DOID:1883
NCIt41 C3098
MeSH36 D006526
ICD9CM28 070.7

Related Diseases for Hepatitis C

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Hepatitis C:



Diseases related to hepatitis c

Symptoms for Hepatitis C

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Sources:
9Disease Ontology
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Symptoms:

9 (show all 9)
  • jaundice
  • fever
  • fatigue
  • abdominal pain
  • loss of appetite
  • nausea
  • vomiting
  • joint pain
  • clay-colored bowel movements

Drugs & Therapeutics for Hepatitis C

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Genetic Tests for Hepatitis C

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Anatomical Context for Hepatitis C

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Sources:
34MalaCards, 15FMA
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MalaCards organs/tissues related to Hepatitis C:

34
Liver, T cells, Kidney, Testes, B cells, Thyroid, Skin, Eye, Monocytes, Bone, Endothelial, Nk cells, Bone marrow, Brain, Myeloid, Tongue, Heart, Lymph node, Whole blood, Pancreatic islet, Colon, Pituitary, Salivary gland, Lung, Spinal cord, Cortex, Prostate, Adrenal cortex, Breast, Spleen, Smooth muscle

FMA organs/tissues related to Hepatitis C:

15
Liver

Animal Models for Hepatitis C or affiliated genes

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Publications for Hepatitis C

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Sources:
53PubMed
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Articles related to Hepatitis C:

(show top 50)    (show all 5564)
idTitleAuthorsYear
1
MicroRNA-155 controls Toll-like receptor 3- and hepatitis C virus-induced immune responses in the liver. (24383923)
2014
2
Hepatocyte Nuclear Factor 4I+ and Downstream Secreted Phospholipase A2 GXIIB Regulate Production of Infectious Hepatitis C Virus. (24173221)
2014
3
Septic bursitis, a potential complication of protease inhibitor use in hepatitis C virus. (23413416)
2013
4
Hepatitis C virus clearance correlates with HLA-DR expression on proliferating CD8+ T-cells in immune-primed chimpanzees. (24123114)
2013
5
Chronic hepatitis C virus infection is associated with all-cause and liver-related mortality in a cohort of HIV-infected patients with alcohol problems. (24112091)
2013
6
Complement activation correlates with liver necrosis and fibrosis in chronic hepatitis C. (24412908)
2013
7
IL28B polymorphisms are associated with severity ofA liver disease in human immunodeficiency virus (HIV) patients coinfected with hepatitis C virus. (23103287)
2013
8
Subinfectious hepatitis C virus exposures suppress T cell responses against subsequent acute infection. (24270546)
2013
9
Association between insulin resistance and sustained virologic response in hepatitis C treatment, genotypes 1 versus 2 and 3: systematic literature review and meta-analysis. (24055394)
2013
10
Activation of the connective tissue growth factor (CTGF)-transforming growth factor I^ 1 (TGF-I^ 1) axis in hepatitis C virus-expressing hepatocytes. (23056332)
2012
11
A zebrafish model of intrahepatic cholangiocarcinoma by dual expression of hepatitis B virus X and hepatitis C virus core protein in liver. (22729936)
2012
12
MAP-kinase regulated cytosolic phospholipase A2 activity is essential for production of infectious hepatitis C virus particles. (22911431)
2012
13
Diagnostic value of multiple biomarker panel for prediction of significant fibrosis in chronic hepatitis C. (21971609)
2011
14
Hepatitis C and hepatitis B virus infection: epidemiology and risk factors in a large cohort of pregnant women in Lorestan, West of Iran. (22235217)
2011
15
Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and high plasma homocysteine in chronic hepatitis C (CHC) infected patients from the Northeast of Brazil. (21854603)
2011
16
Innate immune genes synergize to predict increased risk of chronic disease in hepatitis C virus infection. (21402922)
2011
17
Hepatic and extra-hepatic sequelae, and prevalence of viral hepatitis C infection estimated from routine data in at-risk groups. (20403169)
2010
18
Polymorphism of OAS-1 determines liver fibrosis progression in hepatitis C by reduced ability to inhibit viral replication. (19515215)
2009
19
Porphyria cutanea tarda as a complication of therapy for chronic hepatitis C. (18855993)
2008
20
Hepatitis C virus receptor expression in normal and diseased liver tissue. (18085708)
2008
21
Hepatitis C virus infection in mouse hepatoma cells co-expressing human CD81 and Sip-L. (18474223)
2008
22
Association of chronic hepatitis C with major depressive disorders: irrespective of interferon-alpha therapy. (17956625)
2007
23
Analysis of mutations within the 5' untranslated region, interferon sensitivity region, and PePHD region as a function of response to interferon therapy in hepatitis C virus-infected patients in India. (16517843)
2006
24
Interferon-alpha suppresses liver cell proliferation in patients with chronic hepatitis C virus infection. (16108765)
2005
25
TNF-{alpha}, chronic hepatitis C and diabetes: a novel triad. (15625348)
2005
26
Binding of hepatitis C virus envelope protein E2 to CD81 up-regulates matrix metalloproteinase-2 in human hepatic stellate cells. (15611113)
2005
27
Effects of combined antiviral therapy on asymptomatic mixed cryoglobulinemia in naive patients with chronic hepatitis C virus infection: a preliminary study. (16416186)
2005
28
Treatment of chronic hepatitis C virus in allogeneic bone marrow transplant recipients. (16062173)
2005
29
Structural biology of human CD81, a receptor for hepatitis C virus]. (15449903)
2004
30
Similar increased serum dipeptidyl peptidase IV activity in chronic hepatitis C and other viral infections. (12727530)
2003
31
Non-organ-specific autoantibodies in children with chronic hepatitis C: clinical significance and impact on interferon treatment. (14583865)
2003
32
Twenty-four vs. forty-eight weeks of re-therapy with interferon alpha 2b and ribavirin in interferon alpha monotherapy relapsers with chronic hepatitis C. (14625812)
2003
33
Porphyria cutanea tarda: multiplicity of risk factors including HFE mutations, hepatitis C, and inherited uroporphyrinogen decarboxylase deficiency. (11855561)
2002
34
Interferon-alpha2a/ribaviran versus interferon-alpha2a alone for the retreatment of hepatitis C patients who relapse after a standard course of interferon. (11346153)
2001
35
Kidney transplantation for end-stage renal failure in liver transplant recipients with hepatitis C viral infection. (11213072)
2001
36
Oxidative stress and antioxidant defense in alcoholic liver disease and chronic hepatitis C]. (10962902)
2000
37
Randomized trial of interferon-alpha plus ursodeoxycholic acid versus interferon plus placebo in patients with chronic hepatitis C resistant to interferon. (10912666)
2000
38
Hepatitis C infection, cryoglobulinemia, and Churg-Strauss syndrome. (11093462)
2000
39
Increases in intrahepatic CD68 positive cells, MAC387 positive cells, and proinflammatory cytokines (particularly interleukin 18) in chronic hepatitis C infection. (10644323)
2000
40
Bcl-2 rearrangement in patients with chronic hepatitis C associated with essential mixed cryoglobulinemia type II. (11023531)
2000
41
Comparison between serum alpha-glutathione S-transferase and aminotransaminases in detecting cytolysis in hepatitis C-infected children. (10328133)
1999
42
Liver tissue expression of CD80 and CD95 antigens in chronic hepatitis C: relationship with biological and histological disease activities. (10413866)
1999
43
Characteristics of chronic hepatitis C in patients infected by human immunodeficiency virus]. (9633204)
1998
44
Serum soluble CD8 and soluble interleukin-2-receptor levels during interferon therapy in chronic hepatitis C]. (9369080)
1997
45
Prevalence of hepatitis C virus associated cryoglobulinemia at a veterans hospital. (9375872)
1997
46
An atypical verrucous carcinoma of the tongue arising in a patient with oral lichen planus associated with hepatitis C virus infection. (9307733)
1997
47
Changes in serum levels of metalloproteinases and their inhibitors by treatment of chronic hepatitis C with interferon. (8625775)
1996
48
Diversity of quasispecies in various disease stages of chronic hepatitis C virus infection and its significance in interferon treatment. (7541387)
1995
49
Hepatitis C virus associated membranous glomerulonephritis. (8556829)
1995
50
Hepatitis C virus antibody titration in patients with chronic hepatitis C, before and after interferon treatment. (1279945)
1992

Variations for Hepatitis C

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Expression for genes affiliated with Hepatitis C

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hepatitis C

Search GEO for disease gene expression data for Hepatitis C.

Pathways for genes affiliated with Hepatitis C

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51PathCards, 31KEGG
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Pathways related to Hepatitis C according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0CLDN9, CLDN6, SCARB1

Compounds for genes affiliated with Hepatitis C

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GO Terms for genes affiliated with Hepatitis C

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17Gene Ontology
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Biological processes related to Hepatitis C according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1viral processGO:0160329.9TBC1D20, ACY3, SCARB1, DDX3X
2calcium-independent cell-cell adhesionGO:0163389.8CLDN9, CLDN6

Molecular functions related to Hepatitis C according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055159.0NOLC1, HDDC2, SPG20, SCARB1, SSB, MEMO1

Products for genes affiliated with Hepatitis C

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hepatitis C

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet