NANBH
MCID: HPT001
MIFTS: 66

Hepatitis C (NANBH) malady

Liver diseases category

Summaries for Hepatitis C

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Sources:
8Disease Ontology, 33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Your liver is the largest organ inside your body. it helps your body digest food, store energy, and remove poisons. hepatitis is an inflammation of the liver. one type, hepatitis c, is caused by the hepatitis c virus (hcv). it usually spreads through contact with infected blood. it can also spread through sex with an infected person and from mother to baby during childbirth. most people who are infected with hepatitis c don't have any symptoms for years. if you do get symptoms, you may feel as if you have the flu. you may also have jaundice, a yellowing of skin and eyes, dark-colored urine, and pale bowel movements. a blood test can tell if you have it. usually, hepatitis c does not get better by itself. the infection can last a lifetime and may lead to scarring of the liver or liver cancer. medicines sometimes help, but side effects can be a problem. serious cases may need a liver transplant. there is no vaccine for hcv. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Hepatitis C, also known as hepatitis c infection, is related to hepatitis and hepatitis a, and has symptoms including loss of appetite, nausea and vomiting. An important gene associated with Hepatitis C is SPG20 (spastic paraplegia 20 (Troyer syndrome)), and among its related pathways is Hepatitis C. The drugs interferon alfa-2a and interferon alfa-2b have been mentioned in the context of this disorder. Affiliated tissues include liver, liver and t cells.

Disease Ontology:8 A viral infectious disease that results in inflammation located in liver, has material basis in hepatitis c virus, which is transmitted by blood from an infected person enters the body of an uninfected person. the infection has symptom fever, has symptom fatigue, has symptom loss of appetite, has symptom nausea, has symptom vomiting, has symptom abdominal pain, has symptom clay-colored bowel movements, has symptom joint pain, and has symptom jaundice.

Wikipedia:63 Hepatitis C is an infectious disease affecting primarily the liver, caused by the hepatitis C virus... more...

Aliases & Classifications for Hepatitis C

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 27ICD9CM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Liver diseases


Aliases & Descriptions:

hepatitis c 8 10 44 33 60
hepatitis c infection 8
hepatitis c, chronic 60
chronic hepatitis c 8
hepatitis nona nonb 8
hepatitis c chronic 44
viral hepatitis c 8
nanbh 8


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Disease Ontology8 DOID:1883
NCIt39 C3098
MeSH34 D006526
ICD9CM27 070.7

Related Diseases for Hepatitis C

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Hepatitis C:



Diseases related to hepatitis c

Clinical Features for Hepatitis C

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Sources:
8Disease Ontology
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Symptoms:

8 (show all 9)
  • loss of appetite
  • nausea
  • vomiting
  • clay-colored bowel movements
  • abdominal pain
  • joint pain
  • jaundice
  • fever
  • fatigue

Drugs & Therapeutics for Hepatitis C

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Hepatitis C

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Anatomical Context for Hepatitis C

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Hepatitis C:

32
Liver, T cells, Kidney, Testes, B cells, Thyroid, Skin, Eye, Monocytes, Endothelial, Bone, Nk cells, Bone marrow, Heart, Brain, Myeloid, Lymph node, Whole blood, Tongue, Breast, Lung, Pituitary, Colon, Pancreatic islet, Spinal cord, Salivary gland, Adrenal cortex, Prostate, Thymus, Smooth muscle, Cortex, Spleen

FMA organs/tissues related to Hepatitis C:

14
Liver

Animal Models for Hepatitis C or affiliated genes

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Publications for Hepatitis C

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Sources:
50PubMed
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Articles related to Hepatitis C:

(show top 50)    (show all 6107)
idTitleAuthorsYear
1
Elucidating novel hepatitis C virus-host interactions using combined mass spectrometry and functional genomics approaches. (24169621)
2014
2
Comparative effectiveness of the hepatitis C virus protease inhibitors boceprevir and telaprevir in a large U.S. cohort. (24206566)
2014
3
Relationship between inosine triphosphate genotype and outcome of extended therapy in hepatitis C virus patients with a late viral response to pegylated-interferon and ribavirin. (23980585)
2014
4
Hepatitis C as a prognostic indicator among noncirrhotic patients hospitalized with alcoholic hepatitis. (24040630)
2013
5
Telaprevir in a patient with chronic hepatitis C and Cryoglobulinemic Glomerulonephritis. (24009104)
2013
6
Hepatitis C virus (HCV)-related cryoglobulinemia: cryoglobulin type and anti-HCV profile. (23467778)
2013
7
Prevalence of insulin resistance in chronic hepatitis C genotype 1 and 3 patients. (24114816)
2013
8
Hepatitis B and C in the armed forces. (24109138)
2013
9
Hepatitis C virus induces interleukin-1I^ (IL-1I^)/IL-18 in circulatory and resident liver macrophages. (24006444)
2013
10
Hepatitis C and blood transfusion among children attending the Sickle Cell Clinic at Mulago Hospital, Uganda. (24235921)
2013
11
ISG56 and IFITM1 proteins inhibit hepatitis C virus replication. (21976647)
2011
12
A Duffy antigen receptor for chemokines (DARC) polymorphism that determines pro-fibrotic chemokine serum concentrations is not directly associated with severity of hepatitis C infection. (21156192)
2011
13
The prevalence of hepatitis C virus infection in oral lichen planus in an ethnic Chinese cohort of 232 patients. (20737935)
2010
14
Efficient hepatitis C virus particle formation requires diacylglycerol acyltransferase-1. (20935628)
2010
15
Amino acid substitution in hepatitis C virus core region and genetic variation near the interleukin 28B gene predict viral response to telaprevir with peginterferon and ribavirin. (20648473)
2010
16
CXCR3 expression on peripheral CD4+ T cells as a predictive marker of response to treatment in chronic hepatitis C. (19423402)
2009
17
Validation of three non-invasive markers in assessing the severity of liver fibrosis in chronic hepatitis C. (19651008)
2009
18
Correlations among the serum levels of some interleukins and the histopathological aspects in chronic viral hepatitis C. (18273504)
2008
19
Pegylated interferon treatment of acute pericarditis associated with acute hepatitis C. (18080927)
2007
20
Evaluation of serum procollagen aminoterminal propeptide III, laminin, and hydroxyproline as predictors of severe fibrosis in patients with chronic hepatitis C. (17613667)
2007
21
Directly observed therapy for the treatment of hepatitis C virus infection in current and former injection drug users. (17645460)
2007
22
Hepatitis C infection is associated with lower lipids and high-sensitivity C-reactive protein in HIV-infected men. (17651029)
2007
23
Polyneuropathy with demyelinating features in mixed cryoglobulinemia with hepatitis C virus infection. (16930357)
2006
24
Proteomic profiling of cellular proteins interacting with the hepatitis C virus core protein. (15846844)
2005
25
Aggressive forms of non-Hodgkin's lymphoma in two patients bearing coinfection of Epstein-Barr and hepatitis C viruses. (15753988)
2005
26
Comparison of recurrence after hepatic resection in patients with hepatitis B vs. hepatitis C-related small hepatocellular carcinoma in hepatitis B virus endemic area. (15780044)
2005
27
Structural biology of human CD81, a receptor for hepatitis C virus]. (15449903)
2004
28
Calcineurin inhibition and disease recurrence in the hepatitis C virus-positive liver transplant recipient. (15482334)
2004
29
Similar increased serum dipeptidyl peptidase IV activity in chronic hepatitis C and other viral infections. (12727530)
2003
30
Case report: severe juvenile type paracoccidioidomycosis with hepatitis C. (12685634)
2003
31
Chronic hepatitis C: updated Swedish consensus. (14514142)
2003
32
Effect of interferon alfa-2b and ribavirin treatment on hepatitis C-associated cryoglobulinemia and rheumatoid factor: comment on the article by Vassilopoulos and Calabrese. (12571874)
2003
33
Evolution of hepatitis C virus-specific T cell responses and cytokine production in chronic hepatitis C patients treated with high doses of interferon-alpha. (11995406)
2002
34
Effect of TT virus co-infection on interferon response in chronic hepatitis C patients. (12296969)
2002
35
Analysis of background factors influencing long-term prognosis of patients with chronic hepatitis C treated with interferon. (11937766)
2002
36
Kidney transplantation for end-stage renal failure in liver transplant recipients with hepatitis C viral infection. (11213072)
2001
37
Virological and histological responses to one year alpha-interferon-2a in hemodialyzed patients with chronic hepatitis C. (11399913)
2001
38
The hepatitis C virus (HCV) induces a long-term increase in interleukin-10 production by human CD4+ T cells (H9). (11282549)
2001
39
Efficacy of interferon for chronic hepatitis C virus-related hepatitis in kidney transplant candidates on hemodialysis: results after transplantation. (11316166)
2001
40
Clinical implications of HCV quasispecies heterogeneity in patients with hepatitis C]. (11436653)
2001
41
Hepatitis C: virology, clinical aspects and the relation to cryoglobulinemia. (10925464)
2000
42
Circulating IL-2 and IL-10 in chronic active hepatitis C with respect to the response to IFN treatment. (11073139)
2000
43
Asymptomatic intrahepatic choledochal cyst associated with chronic active hepatitis C. (9951923)
1998
44
An atypical verrucous carcinoma of the tongue arising in a patient with oral lichen planus associated with hepatitis C virus infection. (9307733)
1997
45
Chronic hepatitis C: T-helper1/T-helper2 imbalance could cause virus persistence in peripheral blood. (9458493)
1997
46
Incidence of hepatitis C in patients requiring orthopaedic surgery. (7593117)
1995
47
Hepatitis C virus genotypes 1 and 2 respond to interferon-alpha with different virologic kinetics. (7561212)
1995
48
Abducent nerve paralysis during interferon alpha-2a therapy in a case of chronic active hepatitis C. (7827383)
1994
49
High prevalence of hepatitis C virus RNA in the supernatant and the cryoprecipitate of patients with essential and secondary type II mixed cryoglobulinemia. (7525697)
1994
50
Side effects of interferon on endocrine and respiratory system in 545 cases of chronic hepatitis C]. (7515124)
1994

Genetic Variations for Hepatitis C

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Expression for genes affiliated with Hepatitis C

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hepatitis C

Search GEO for disease gene expression data for Hepatitis C.

Pathways for genes affiliated with Hepatitis C

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29KEGG
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Pathways related to Hepatitis C according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.0CLDN6, CLDN9, SCARB1

Compounds for genes affiliated with Hepatitis C

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GO Terms for genes affiliated with Hepatitis C

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16Gene Ontology
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Biological processes related to Hepatitis C according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1modulation by virus of host morphology or physiologyGO:01904810.9ACY3, DDX3X, SCARB1, PSMA7
2calcium-independent cell-cell adhesionGO:01633810.9CLDN6, CLDN9

Molecular functions related to Hepatitis C according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:04280211.2ACY3, CLDN6, CLDN9, PSMA7

Products for genes affiliated with Hepatitis C

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hepatitis C

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet