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Hepatitis C malady
9 symptoms, 15 drugs, 1077 genes, 26 tissues, 851 related diseases, 28 phenotypes, 3471 articles, clinical trials.

Summaries for Hepatitis C

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6Disease Ontology, 23MedlinePlus, 44Wikipedia, 22MalaCards
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MedlinePlus: Hepatitis c is one type of hepatitis - a liver disease - caused by the hepatitis c virus (hcv). it usually spreads through contact with infected blood. it can also spread through sex with an infected person and from mother to baby during childbirth. most people who are infected with hepatitis c don't have any symptoms for years. a blood test can tell if you have it. usually, hepatitis c does not get better by itself. the infection can last a lifetime and may lead to scarring of the liver or liver cancer. medicines sometimes help, but side effects can be a problem. serious cases may need a liver transplant. there is no vaccine for hcv. nih: national institute of diabetes and digestive and kidney diseases23

MalaCards: Hepatitis C, also known as hepatitis c, chronic, is related to carcinoma and leukemia, and has symptoms including fever, fatigue and loss of appetite. An important gene associated with Hepatitis C is HM13 (histocompatibility (minor) 13), and among its related pathways are Tec Kinases Signaling and TGF-Beta Pathway. The drugs interferon alfa-2a,recombinant and interferon and the compounds estrogen and wortmannin have been mentioned in the context of this disorder. Affiliated tissues include liver, liver and bone marrow, and related mouse phenotypes are homeostasis/metabolism and cellular.

Disease Ontology: A viral infectious disease that results in inflammation located in liver, has material basis in hepatitis c virus, which is transmitted by blood from an infected person enters the body of an uninfected person. the infection has symptom fever, has symptom fatigue, has symptom loss of appetite, has symptom nausea, has symptom vomiting, has symptom abdominal pain, has symptom clay-colored bowel movements, has symptom joint pain, and has symptom jaundice.6

Wikipedia: Hepatitis C is an infectious disease affecting primarily the liver, caused by the hepatitis C virus...44 more...

Aliases & Descriptions for Hepatitis C

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6Disease Ontology, 8DISEASES, 32Novoseek , 23MedlinePlus, 43UMLS, 40SNOMED-CT, 24MeSH, 27NCIt, 19ICD9CM
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Aliases & Descriptions:

hepatitis c 6 8 32 23 43
hepatitis c, chronic 43
chronic hepatitis c 6
hepatitis nona nonb 6
hepatitis c chronic 32
nanbh 6

External Ids:

NCIt27 C3098
SNOMED-CT40 50711007, 186643004, 186634008 123324009, 154349000, more
ICD9CM19 070.7

Related Diseases for Hepatitis C

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13GeneCards, 14GeneDecks
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Disease types for hepatitis c family:

hepatitis a hepatitis e
hepatitis d hepatitis b
hepatitis

Diseases related to hepatitis c by text searches and GeneDecks gene sharing:

(show top 50)    (show all 843)
idRelated DiseaseScoreTop Affiliating Genes
1carcinoma160.2PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIAS3, PIK3R2
2leukemia132.9PIK3CB, PIK3CD, PIAS2, PIK3CA, PIK3R3, PIK3R2
3hepatocellular carcinoma118.2PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, PIN1
4pancreatitis111.8PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
5arthritis108.7PIK3CD, PIK3CG, PIN1, PDCD1, RELA, CNR1
6thyroiditis100.3PIK3CB, PIK3CA, PIK3R1, PIK3CG, PIN1, COG2
7adenocarcinoma98.0PIK3CB, PIK3CA, PIK3R1, PIK3CG, PIN1, PIK3C3
8fibrosis94.3PIK3CA, PIAS3, PIK3CG, PIN1, RELA, REN
9lupus erythematosus89.5PIK3CD, PIK3CG, COG2, NCL, NCR3, PDCD1
10gastric cancer87.4PIK3CB, PIK3CA, PIK3R1, PIAS1, PIK3CG, PIN1
11cholesterol83.9PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIAS1
12diabetes mellitus81.4PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
13influenza80.8PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
14atherosclerosis78.3PIK3CG, LRP8, COG2, PDCD1, REN, CNR1
15esophagitis77.0PIK3CB, PIK3CA, PIK3CG, PIN1, PIK3C3, RELA
16hypoxia74.9PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIAS4, PIK3CG
17prostatitis73.8PIK3CB, PIK3CD, PIAS2, PIK3CA, PIK3R3, PIAS3
18obesity73.0PIK3CB, PIK3CA, PIK3R1, PIK3CG, COG2, NCR3
19anemia72.3PDCD1, RELA, REN, PCNA, RB1, SELE
20retinitis69.2PIK3CA, PIK3CG, CNR1, CNR2, CNTF, RDH11
21non-hodgkin lymphoma69.2PIK3CA, PDCD1, CNR1, CNR2, KIR2DS3, KIR2DS5
22psoriasis67.4CNR1, KIR2DS3, KIR2DS5, KIR3DL2, KIR3DL3, KIR2DP1
23pneumonia67.4COG2, RELA, RBP4, SELE, SERPINC1, SERPINF2
24hypertension66.2PIK3CB, PIK3R1, PIK3CG, LRP8, COG2, REN
25melanoma64.3PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
26nephropathy64.2COG2, PDCD1, RELA, REN, PCNA, RB1
27insulin resistance63.6PIK3CB, PIK3CA, PIK3R2, PIK3R1, PIK3CG, COG2
28immunodeficiency61.0PIK3CD, PDCD1, KIR3DL1, MYD88, BMP6, BLZF1
29neuronitis60.2PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
30peritonitis60.1COG2, RELA, REN, CNTF, KIR2DL1, KIR2DL3
31gonococcal synovitis59.6PIK3CB, PIK3CA, PIK3R1, PIK3CG, PDCD1, RELA
32systemic lupus erythematosus57.8NCL, PDCD1, RBP4, SELE, VCAM1, BLZF1
33colorectal cancer57.7PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
34sarcoidosis57.6KIR2DL3, SELE, SELP, VIM, VEGFA, VDR
35hepatitis56.4RBP4, SELP, SERPINA1, SEPSECS, VIPR1, CD58
36viral hepatitis55.8PCNA, SERPINC1, SERPINA1, SEPSECS, MYB, CLIC1
37sjogren's syndrome53.9PDCD1, KIR2DS3, KIR2DS5, KIR2DL1, KIR2DL3, KIR3DS1
38vasculitis53.2PDCD1, REN, SELE, SELP, SERPINC1, SERPINA1
39coronary heart disease52.9COG2, SELE, SELP, SERPINC1, SERPINF2, SERPINA6
40glomerulonephritis52.9REN, PCNA, RBP4, SELP, SERPINC1, SERPINF2
41myopathy52.7PIK3R1, PIK3C3, RELA, SELE, VIM, VCAM1
42liver cirrhosis52.4REN, CNR1, CNR2, RBP4, SERPINC1, SERPINF2
43blindness52.2PIK3CG, COG2, REN, CNR1, CNTF, RBP4
44ovarian cancer52.0PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R1, PIK3CG
45thrombocytopenia51.8KIAA0101, SELE, SELP, SERPINC1, MYB, BMP6
46neuropathy51.6REN, CNR1, CNTF, SELE, SERPING1, VIM
47galactosemia51.5PDCD1, CNR1, RBP4, SERPINC1, SERPINA1, SEPSECS
48myeloma50.9PIK3CA, PIAS3, PIK3R2, PIK3R1, PIK3CG, RELA
49malaria50.7PIAS2, PIAS3, PIAS4, PIAS1, PI4KB, PIK3C3
50fatty liver disease50.5RBP4, SELE, SELP, SERPINA1, NAMPT, BMP6

Graphical network of the top 20 diseases related to hepatitis c:



Graphical network of diseases related to hepatitis c

Clinical Features for Hepatitis C

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6Disease Ontology
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Symptoms: fever, fatigue, loss of appetite, nausea, vomiting, abdominal pain, clay-colored bowel movements, joint pain, jaundice.6

Drugs & Therapeutics for Hepatitis C

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4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
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Approved drugs:

Search CenterWatch for hepatitis c

Drug clinical trials:

Search ClinicalTrials for hepatitis c

Search NIH Clinical Center for hepatitis c

Search CenterWatch for hepatitis c

Inferred drug relations via UMLS/NDF-RT:

43 28 interferon, interferon alfa 2-b, interferon alfa-2a, interferon alfa-2a,recombinant, interferon alfa-2b, interferon alfa-2b,recombinant, interferon alfa-3n,human leukocyte derived, interferon alfacon-1, interferon beta-1a,recombinant, interferon beta-1b,recombinant, interferon gamma-1b, peginterferon, peginterferon alfa-2a, peginterferon alfa-2b, ribavirin

Genetic Tests for Hepatitis C

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Anatomical Context for Hepatitis C

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11FMA, 22MalaCards
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MalaCards organs/tissues related to hepatitis c:

22
Liver, Bone marrow, Whole blood, Lymph node, Brain, Cortex, Spinal cord, Heart, Colon, Kidney, Thyroid, Skin, Myeloid, Monocytes, Nk cells, T cells, B cells, Endothelial, Fetal brain, Parietal lobe, Pons, Fetal liver, Fetal thyroid, Pancreatic islet, Adrenal cortex, Pituitary

FMA organs/tissues related to hepatitis c:

11
Liver

Phenotypes for genes affiliated with Hepatitis C

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25MGI
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MGI Mouse Phenotypes related to hepatitis c:

25 (show all 28)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1homeostasis/metabolism phenotypeMP:000537655.6PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIK3CG
2cellular phenotypeMP:000538452.8PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3R5, PIK3CG
3mortality/agingMP:001076849.2PIK3CB, PIK3CA, PIAS4, PIAS1, PIK3C3, LRP8
4growth/size phenotypeMP:000537840.3PIK3CB, PIK3CA, PIK3R1, PIAS1, PIK3CG, PIN1
5cardiovascular system phenotypeMP:000538538.2PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIK3CG
6immune system phenotypeMP:000538735.8PIK3CD, PIAS4, PIAS1, PIK3R5, PIK3C3, REN
7hematopoietic system phenotypeMP:000539734.9PIAS4, PDCD1, CNTF, KIAA0101, PCNA, BTLA
8behavior/neurological phenotypeMP:000538631.1PIK3CA, PIK3C3, LRP8, REN, CNR1, CNTF
9nervous system phenotypeMP:000363129.0LRP8, PDCD1, RELA, REN, CNR1, CNTF
10normal phenotypeMP:000287327.6PI4KA, PIAS2, PIK3R1, PIK3C3, LRP8, RELA
11tumorigenesisMP:000200626.4PIK3CB, PIK3CA, PIK3R2, PIK3R1, RB1, BRAF
12muscle phenotypeMP:000536924.0PIK3CA, PIK3R2, PIK3R1, PIK3CG, PIK3C3, PDCD1
13digestive/alimentary phenotypeMP:000538123.7SFRP4, RB1, RBP2, VIPR1, BRAF, VEGFA
14reproductive system phenotypeMP:000538923.7PIK3CA, LRP8, REN, RDH11, VRK1, SFRP4
15integument phenotypeMP:001077123.4PIK3CG, PIN1, RELA, CNR1, CNR2, RB1
16vision/eye phenotypeMP:000539123.0PIK3CA, PIN1, PDCD1, RELA, RDH11, RB1
17liver/biliary system phenotypeMP:000537022.9PIK3C3, SERPINC1, SERPINA6, VEGFA, LPL, MYCN
18embryogenesis phenotypeMP:000538020.4PIK3CB, PIK3CA, PIK3C3, SEMA3C, SERPINC1, VIM
19renal/urinary system phenotypeMP:000536719.9PDCD1, REN, SFRP4, SELP, SERPINA6, BRAF
20skeleton phenotypeMP:000539019.5PIK3CD, PIK3CG, RELA, CNR1, RB1, BRAF
21no phenotypic analysisMP:000301219.4PIK3CD, PIK3R1, CNR1, PCNA, RB1, SERPINA6
22adipose tissue phenotypeMP:000537518.7PIK3CA, PIK3R1, CNR1, RB1, BRAF, LPL
23respiratory system phenotypeMP:000538817.6SFRP4, SELP, LPL, MYCN, BMPER, LIPA
24limbs/digits/tail phenotypeMP:000537115.5RELA, RB1, VEGFA, VDR, MYCN, BMPER
25craniofacial phenotypeMP:000538215.4MYCN, BMPER, YBX1, LBR, LAMA3, ATR
26hearing/vestibular/ear phenotypeMP:000537715.3RB1, VDR, MYC, MYD88, BMPER, CLDN9
27other phenotypeMP:000539515.1CNR1, RBP2, KDR, LEPR, LDLR, LAMC2
28endocrine/exocrine gland phenotypeMP:000537912.7VIPR1, LDLR, CD40LG, GUSB, IL2, IL22

Publications for genes affiliated with Hepatitis C

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35PubMed
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Articles related to hepatitis c:

(show top 50)    (show all 3471)
idTitleAuthorsYearAffiliating Genes
1Systemic and intrahepatic interferon-gamma-inducible protein 10 kDa predicts the first-phase decline in hepatitis C virus RNA and ov erall viral response to therapy in chronic hepatitis C. (20186843)Askarieh G.... Lagging M.2010CXCL10
2Association of a single nucleotide polymorphism near the interleukin-28B gene with response to hepatitis C therapy in HIV/hepatitis C virus-coinfected patients. (20389235)RallA^n N.I.... Soriano V.2010IL28B
3Elevation of interleukin-18 in chronic hepatitis C: i mplications for hepatitis C virus pathogenesis. (19740312)Sharma A.... Chawla Y.2009IL18
4FOXP3 expression in hepatitis C virus-specific CD4+ T cells during acute hepatitis C. (19596013)Heeg M.H.... Diepolder H.M.2009CD4, FOXP3
5Cellular vimentin content regulates the protein level of hepatitis C virus core protein and the hepatitis C virus production in cultured cells. (19013628)Nitahara-Kasahara Y.... Nishijima M.2009VIM
6Fatty acid synthase is up-regulated during hepatitis C virus infection and regulates hepatitis C virus entry and production. (18830996)Yang W.... Wang T.2008FASN
7The transforming growth factor-beta high-producer genotype is associated with response to hepatitis C virus-specific therapy in HIV-positive patients with acute hepatitis C. (18580607)Nattermann J.... Spengler U.2008TGFB1, BMP6
8Association of a genetic polymorphism in ectonucleotide pyrophosphatase/phosphodiesterase 1 with hepatitis C virus infection and hepatitis C virus core antigen levels in subjects in a hyperendemic area of Japan. (19107338)Takahama Y.... Tsubouchi H.2008ENPP1
9Analysis of hepatitis C virus-specific CD8+ T-cells with HLA-A*24 tetramers during phlebotomy and interferon therapy for chronic hepatitis C. (17786365)Kaji K.... Kaneko S.2007IFNA1
10Hepatic stellate cell activation in liver transplant patients with hepatitis C recurrence and in non-transplanted patients with chronic hepatitis C. (17600343)Cisneros L.... Rimola A.2007TGFB1
11Effects of Silybum marianum on serum hepatitis C virus RNA, alanine aminotransferase levels and well-being in patients with chronic hepatitis C. (16460486)Gordon A.... Roberts S.K.2006GPT
12Down-regulation of heme oxygenase-1 by hepatitis C virus infection in vivo and by the in vitro expression of hepatitis C core protein. (15319861)Abdalla M.Y.... Schmidt W.N.2004HMOX1
13Prediction of sustained virological response in liver transplant recipients with recurrent hepatitis C virus following combination pegylated interferon alfa-2b and ribavirin therapy using tissue hepatitis C virus reverse transcriptase polymerase chain reaction testing. (15108250)Neff G.W.... Schiff E.R.2004IFNA2
14Hepatitis C virus genotypes and hepatic fibrosis regulate 24-h decline of serum hepatitis C virus RNA during interferon therapy in patients with chronic hepatitis C. (12653888)Karino Y.... Matsushima T.2003IFNA1
15Interaction between hepatitis C virus core protein and translin protein--a possible molecular mechanism for hepatocellular carcinoma and lymphoma caused by hepatitis C virus. (12532453)Li K.... Chen J.M.2003RDH11, TSN
16Expression and coordinated regulation of matrix metalloproteinases in chronic hepatitis C and hepatitis C virus-induced liver cirrhosis. (12760742)Lichtinghagen R.... Boeker K.H.2003MMP1
17Comparative evaluation of the total hepatitis C virus core antigen, branched-DNA, and amplicor monitor assays in determining viremia for patients with chronic hepatitis C during interferon plus ribavirin combination therapy. (12843066)Veillon P.... Lunel F.2003IFNA1
18Antibody responses against B-cell epitopes of the hypervariable region 1 of hepatitis C virus in self-limiting and chronic human hepatitis C followed-up using consensus peptides. (11782929)Isaguliants M.G.... Nordenfelt E.2002VIPR1
19The response of hepatitis C virus and TT virus to high dose and long duration interferon-alpha therapy in naA^ve chronic hepatitis C patients. (11684312)Dai C.Y.... Chang W.Y.2002GPT, IFNA1
20Lactoferrin inhibits hepatitis C virus viremia in chronic hepatitis C patients with high viral loads and HCV genotype 1b. (11922584)Iwasa M.... Teraguchi S.2002LTF
21Genetic immunization of wild-type and hepatitis C virus transgenic mice reveals a hierarchy of cellular immune response and tolerance induction against hepatitis C virus structural proteins. (11711603)Satoi J.... Liang T.J.2001UBE2K
22Hepatitis C and the leptin system: bound leptin levels are elevated in patients with hepatitis C and decrease during antiviral therapy. (11336170)Widjaja A.... Brabant G.2001LEP, LSL
23Study of hepatitis C virus specific immune responses in anti-HCV positive patients without hepatitis C viremia (11498684)Yao P.... Hu D.2000IFNG
24Effect of hepatitis C virus on hepatocyte proliferation and DNA ploidy in patients with chronic hepatitis C. (10965551)Werling K.... Szalay F.2000CCNA2
25Association of hepatitis C virus-specific CD8+ T cells with viral clearance in acute hepatitis C. (10823750)GrA1ner N.H.... Pape G.R.2000IFNG
26Hepatitis C virus-specific T-cell reactivity during interferon and ribavirin treatment in chronic hepatitis C. (10648463)Cramp M.E.... Naoumov N.V.2000IFNG, IL10, IFNA1
27Transfusion-acquired hepatitis C: the Danish lookback experience. The Danish HCV [hepatitis C virus] Lookback Group. (10037130)Christensen P.B.... Krarup H.B.1999GPT
28Antigen-specific cytokine response to hepatitis C virus core epitopes in HIV/hepatitis C virus-coinfected patients. (10449283)Woitas R.P.... Spengler U.1999TNFRSF8
29Discordance between serum alanine aminotransferase (A LT) and virologic response to IFN-alpha2b in chronic hepatitis C patients with high and low pretreatment serum hepatitis C virus RNA titers. (9506457)Blatt L.M.... Conrad A.1998IFNA1
30Cellular immunity to hepatitis C virus core protein and the response to interferon in patients with chronic hepatitis C. (9731578)Lasarte J.J.... Prieto J.1998IL2
31Serologic and virologic profiles of hepatitis C infection in renal transplant candidates. New England Organ Bank Hepatitis C Study Group. (9631834)Natov S.N.... Pereira B.J.1998ALB
32Effect of immunosuppression on composition of quasispecies population of hepatitis C virus in patients with chronic hepatitis C coinfected with human immunodeficiency virus. (9186827)Toyoda H.... Hayakawa T.1997VIPR1
33Comparison of HCV RNA assays for the detection and quantification of hepatitis C virus RNA levels in serum of patients with chronic hepatitis C treated with interferon. (9131466)Trabaud M.A.... TrAcpo C.1997GPT
34Early loss of serum hepatitis C virus RNA can predict a sustained response to interferon therapy in patients with chronic hepatitis C. (8995939)Karino Y.... Matsushima T.1997IFNA1
35Cyclosporine therapy affects aminotransferase activity but not hepatitis C virus RNA levels in chronic hepatitis C. (9076626)Kakumu S.... Yoshioka K.1997IFNA1
36Importance of pretreatment viral load and monitoring of serum hepatitis C virus RNA in predicting responses to interferon-alpha2a treatment of chronic hepatitis C. Hanshin Chronic Hepatitis C Study Group. (9402109)Wada M.... Shimoyama T.1997IFNA2
37Immunoglobulin M antibody response to hepatitis C virus core protein in patients with chronic hepatitis C. (9343983)Kao J.H.... Chen D.S.1997CD40LG, GPT
38Nucleotide sequence diversity of hypervariable region 1 of hepatitis C virus in Japanese hemophiliacs with chronic hepatitis C and patients with chronic posttransfusion hepatitis C. (8695870)Toyoda H.... Hayakawa T.1996VIPR1
39Quantitative assessment of hepatitis C virus RNA and IgM antibodies to hepatitis C core in chronic hepatitis C. (8834020)Martinelli A.L.... Dusheiko G.M.1996CD40LG
40Production of interleukin-2 in response to synthetic peptides from hepatitis C virus E1 protein in patients with chronic hepatitis C: relationship with the response to interferon treatment. (8836894)Sarobe P.... Prieto J.1996IL2
41Two dose regimens of recombinant interferon-alpha-2b in chronic hepatitis C virus infection. Biochemistry, hepatitis C virus RNA, and liver histology as response indices. (8578174)BjA... Ranek L.1995IFNA2
42Treatment of chronic hepatitis C with interferon-alpha: sustained absence of hepatitis C virus RNA from serum after four courses of therapy. (7589775)Toyoda H.... Takahashi M.1995IFNA1
43Volunteer blood donors with antibody to hepatitis C virus: clinical, biochemical, virologic, and histologic features. The Hepatitis C Study Group. (7542854)Shakil A.O.... Di Bisceglie A.M.1995GPT
44Serial quantitative analysis of serum hepatitis C virus RNA level in patients with acute and chronic hepatitis C. (7930476)Naito M.... Kamada T.1994GPT
45Immunoglobulin M and A antibodies to hepatitis C core antigen in chronic hepatitis C virus infection. (7528259)Lau G.K.... Lau J.Y.1994CD40LG
46Rapid clearance of hepatitis C virus RNA in peripheral blood mononuclear cells of patients with clotting disorders and chronic hepatitis C treated with alpha-2b interferon is not a predictor for sustained response to treatment. (7918078)Peerlinck K.... Vermylen J.1994IFNA2
47Cellular and humoral immune reactions against autoantigens and hepatitis C viral antigens in chronic hepatitis C. (7523226)Koskinas J.... Williams R.1994ASGR2
48In vitro secretion of anti-GOR protein and anti-hepatitis C virus antibodies in patients with chronic hepatitis C. (7523227)LAPhr H.F.... Meyer zum BA1schenfelde K.H.1994GPT
49Hepatitis C virus antibody titration in patients with chronic hepatitis C, before and after interferon treatment. (1279945)Takahashi M.... Tsuji T.1992GPT, IFNA1
50Significance of IgM antibody to hepatitis C virus in patients with chronic hepatitis C. (1317344)Brillanti S.... Barbara L.1992CD40LG

Expression for genes affiliated with Hepatitis C

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Hepatitis C

Pathways for genes affiliated with Hepatitis C

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36QIAGEN, 20KEGG, 38Reactome, 41Thomson Reuters, 10EMD Millipore, 3Cell Signaling Technology, 37R&D Systems
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Pathways related to hepatitis c according to GeneDecks:

(show top 50)    (show all 420)
idPathwayScoreTop Affiliating Genes
1Tec Kinases Signaling3624.3PIK3R3, PIK3R2, PIK3R1, MYD88, BMP6, BMP8A
2TGF-Beta Pathway3621.2PIK3R3, PIK3R2, PIK3R1, BMP6, BMP8A, KDR
3PAK Pathway3620.5PIK3R3, PIK3R2, PIK3R1, BMP6, BMP8A, PAK1
4Toxoplasmosis2018.9PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
5PEDF Induced Signaling3618.5RELA, BRAF, BMP6, RAF1, BCL2, BCL2L1
6p70S6K Signaling3616.6PIK3R3, PIK3R2, PIK3R1, BMP6, BMP8A, RAF1
7Interferon Pathway3616.4PIK3R3, PIK3R2, PIK3R1, ATF4, JAK1, IRS1
8Pancreatic Adenocarcinoma3616.2PIK3R3, PIK3R2, PIK3R1, RB1, BRAF, BMP6
9Innate Immune System3815.8PIK3C3, BCL2L1, B2M, CD14, CD4, CD19
10Apoptosis2015.4PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
11Colorectal Cancer Metastasis3615.1PIK3R3, PIK3R2, PIK3R1, BRAF, MYC, BCL2L1
12Phospholipase-C Pathway3614.9BMP6, BMP8A, RAF1, KDR, LCK, LAMA3
13Intestinal immune network for IgA production2014.8CD28, CD86, CD40LG, CD80, CD40, ITGA4
14Activation of PKA through GPCR3614.7BRAF, BMP6, BMP8A, RAF1, KDR, CHUK
15IP3 Pathway3614.6PIK3R3, PIK3R2, PIK3R1, BMP6, BMP8A, KDR
16Neurotrophin signaling pathway2014.5PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R5
17Immune response_TLR signaling pathways4113.7RELA, MYD88, CHUK, JUN, CD14, IRAK3
18Amoebiasis2013.7PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
19Nanog in Mammalian ESC Pluripotency3613.6BRAF, BMP6, BMP8A, RAF1, KDR, FLT1
20Immune response_CD28 signaling4113.6PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
21Immune response Fc epsilon RI pathway1013.5PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
22Apoptosis and survival_Apoptotic TNF-family pathways4113.5BID, BCL2, BCL2L1, BAX, CD27, FASLG
23Apoptosis and survival_Lymphotoxin-beta receptor signaling4113.3RELA, VCAM1, CHUK, BAX, JUN, IL2
24Development FGFR signaling pathway1013.3PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
25Translation _Regulation of EIF4F activity4113.1PIK3CB, PIK3CA, PIK3R3, PIK3R2, PIK3R1, PAK1
26Germ Cell-Sertoli Cell Junction Dynamics3613.0PIK3R3, PIK3R2, PAK1, PAK2, ITGB1, MAPK8
27Translation _Regulation of EIF2 activity4113.0PIK3CB, PIK3CA, PIK3R3, PIK3R2, PIK3R1, RAF1
28Development_Thrombopoietin-regulated cell processes4112.9PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
29Translation_Insulin regulation of translation4112.9PIK3CB, PIK3CD, PIK3R3, PIK3R2, PIK3R1, RAF1
30Immune response_IL-1 signaling pathway4112.7RELA, MYD88, CHUK, UBC, JUN, FOS
31Angiogenesis312.7REN, KDR, JAG1, CDH5, ITGB1, ITGB3
32Development Leptin signaling via PI3K-dependent pathway1012.5PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, LEPR
33Immune response Oncostatin M signaling via MAPK in human cells1012.3RAF1, JUN, JAK1, MMP1, MMP13, MMP3
34Development VEGF-family signaling1012.3PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
35Development EGFR signaling via PIP31012.2PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
36Toll Comparative Pathway3612.2MYD88, CHUK, CD14, IRAK3, MAPK8, MAPK12
37Development EGFR signaling via small GTPases1012.1PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
38Transcription PPAR Pathway1012.1PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, RAF1
39Signal transduction AKT signaling1012.0PIK3CB, PIK3CD, PIK3R3, PIK3R2, PIK3R1, IRS1
40Development_GDNF family signaling4111.9PIK3CB, PIK3CA, PIK3R2, PIK3R1, RELA, RAF1
41Non-small cell lung cancer2011.9PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
42Regulation of lipid metabolism_Insulin signaling-generic cascades4111.9PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
43IL-2 Signaling Pathways3711.9PIK3CB, PIK3CD, PIK3R1, PIK3CG, BRAF, RAF1
44Development Growth hormone signaling via PI3K/AKT and MAPK cascades1011.8PIK3CA, PIK3R1, RAF1, MTOR, JUN, FOS
45Immune response_ICOS pathway in T-helper cell4111.7PIK3CB, PIK3CD, PIK3CA, PIK3CG, GNB3, AKT1
46Glioblastoma Multiforme3611.6PIK3R3, PIK3R2, PIK3R1, RB1, BRAF, RAF1
47mTOR signaling pathway2011.5PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
48Cytoskeleton remodeling FAK signaling1011.4PIK3CB, PIK3CD, PIK3R3, PIK3R2, RAF1, PAK1
49Translation_Non-genomic (rapid) action of Androgen Receptor4111.4PIK3CA, PIK3R1, RELA, RAF1, MTOR, FOXO3
50UVC-Induced MAPK Signaling3611.1BRAF, RAF1, ATR, JUN, FOS, MAPK8

Compounds for genes affiliated with Hepatitis C

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Sources:
32Novoseek , 42Tocris Bioscience, 9DrugBank, 18HMDB, 34PharmGKB
See all sources

Compounds related to hepatitis c according to GeneDecks:

(show top 50)    (show all 416)
idCompoundScoreTop Affiliating Genes
1estrogen32 27.7PIK3CB, PIK3R1, PIAS1, COG2, NCL, PCNA
2wortmannin32 42 23.1PIK3CB, PIK3CD, PIK3CA, PIK3R1, PI4KB, PIK3CG
3genistein32 9 18 9 25.0PIK3CA, PIK3R1, PIK3CG, CNTF, PCNA, RB1
4progesterone32 42 9 18 9 24.3PIK3CA, PIK3R1, PIAS1, CNTF, SFRP4, PCNA
5arachidonic acid32 9 18 9 22.0PIK3CA, CNR1, SELP, SERPINA1, VIM, LPL
6butyrate32 18.7PCNA, RB1, VIM, VDR, MYC, MYB
7ribavirin32 34 9 9 21.3VIPR1, LEP, MX1, LBR, CD81, CD40LG
8pge232 18.0REN, CNTF, SELE, VCAM1, RAF1, CIITA
9polyacrylamide32 17.6NCL, RB1, RBP4, SERPINA6, SERPINA1, BLZF1
10prednisolone32 9 9 19.5SERPINA6, VCAM1, MYC, BMP6, CHKB, LCN2
11tamoxifen32 34 9 9 20.2PIK3CA, PCNA, SELE, SERPINC1, SERPINA6, VIM
12quercetin32 42 9 18 9 20.3PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
13thapsigargin32 42 17.1PIK3CG, CNR1, PCNA, MYB, RAF1, BLZF1
14zidovudine32 9 9 18.1LPL, MYC, UGT1A7, UGT1A9, LBR, B2M
15gp 13032 15.9PIK3R1, CNTF, BMP6, BCL2L1, BCR, LEPR
16polyinosinic-polycytidylic acid32 15.8SELE, VCAM1, LGALS9, CIITA, CD83, CD40
17okadaic acid32 42 16.4PIK3CA, PIK3R1, NCL, RELA, RB1, VIM
18carbohydrates32 15.2SELE, SELP, SERPINA6, BSG, VCAM1, BLZF1
19prostaglandin32 14.8REN, CNTF, VIM, CD40, MMP1, MMP13
20p00332 14.3COG2, RB1, SERPINA1, RASSF1, LIPC, LEP
21nifedipine32 9 9 16.1PIK3CG, REN, SELE, BMP6, LEP, LDLR
22sialic acid32 14.1RBP4, SERPINF2, SERPINA6, BCR, CD79A, CD55
23tetracycline32 9 9 16.0RB1, MYCN, FURIN, CDKN2A, CD40LG, MMP1
24con a32 14.0LBR, FURIN, CD28, CD79A, CD69, MMP14
25etanercept32 9 9 15.9LEP, MMP1, MMP12, MMP3, FCGR3A, IL10
26dmso32 13.8SELP, VIM, BMP6, UROD, LGALS4, CD36
27bezafibrate32 9 9 15.7COG2, LPL, LIPC, CHKB, LDLR, INS
28hydroxyurea32 9 9 15.6NCL, PCNA, VCAM1, MYC, MYCN, CHEK2
29adpribose32 13.6PIK3CA, PIK3CG, PCNA, RB1, BID, PARP1
30erythromycin32 9 9 15.6VCAM1, BCL2L1, MPO, CD40LG, MMP2, MMP9
31egcg32 13.2PIK3CG, RAF1, BCL2L1, CHUK, UGT1A1, LDLR
32carboplatin32 34 9 9 16.0RB1, VEGFA, BID, PARP1, KDR, BCL2
33threonine32 13.0RAF1, LCK, CD4, IL1RAPL2, IL2RB, IFNB1
34polyethylene glycol32 13.0SELE, SERPINC1, BCHE, CHKB, MUC1, MPO
35verapamil32 34 9 18 9 16.9REN, MYC, LDLR, MTTP, CDH1, INSR
36citrate32 12.8SELP, VDR, BLZF1, CHKB, CD79A, MKI67
37inositol32 12.8PIK3CB, PIK3CD, KIR3DL1, LPL, BCR, LBR
38suberoylanilide hydroxamic acid32 12.7MYC, RAF1, BID, PARP1, BCL2, BCL2L1
39cd 43732 12.4MYC, BID, PARP1, BCL2, BCL2L1, BAX
402-methoxyestradiol32 18 13.4PCNA, BID, PAX5, BCL2, BCL2L1, UGT1A1
41p00532 12.2LIPC, SCARB1, MKI67, ENG, CCL5, IGFBP2
42cyclophosphamide32 34 9 9 15.0BCL6, MS4A1, ITGA4, ITGAL, APOH, MBL2
43gf 109203x32 42 12.8PIK3CB, PIK3CG, VEGFA, RAF1, JUN, CDKN1A
44phenylephrine32 9 18 9 14.8LPL, RAF1, LEP, AR, MEF2A, APOB
45dutp32 11.7PCNA, PARP1, BCL2, BCL2L1, BAX, CFLAR
46fluticasone propionate32 42 9 9 14.4SELE, SERPINA6, VCAM1, MPO, MMP9, IL13
47carbachol32 9 9 13.4LBR, IL11, MAPK10, HSPG2, CTSB, NPPB
48staurosporin32 11.1PIK3CA, PIK3CG, BCL2, BCL2L1, JUN, ITGAL
49manumycin32 10.9RAF1, CHUK, INSR, ANXA5, MAPK8, MAPK14
50budesonide32 42 9 9 13.7CD36, IGHE, LTF, CSF2, POMC

GO Terms for genes affiliated with Hepatitis C

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Sources:
12Gene Ontology
See all sources

Cellular components related to hepatitis c according to GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588640.5PIK3CD, PIK3R1, PIK3CG, LRP8, PDCD1, CNR1
2cytoplasmGO:00573740.2PIAS3, PIAS4, PIK3R5, PI4KB, PIK3CG, PIN1
3cytosolGO:00582939.4PI4KA, PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2
4extracellular spaceGO:00561531.4REN, CNTF, SFRP4, RBP4, SELE, SELP
5extracellular regionGO:00557630.7LRP8, KIR3DP1, SERPINC1, SERPINF2, SERPINA1, SERPING1
6integral to plasma membraneGO:00588727.2NCR3, CNR1, CNR2, KIR2DS3, KIR2DS5, KIR3DL2
7nucleoplasmGO:00565419.4PIAS1, PIN1, RELA, PCBP2, PCNA, RB1
8external side of plasma membraneGO:00989718.1BTLA, SELP, VCAM1, KDR, LDLR, LAG3
9cell surfaceGO:00998616.5SFRP4, VEGFA, LPL, VCAM1, SCARB1, LDLR
10membrane raftGO:04512112.6SELE, BSG, RAB5A, LCK, FURIN, CD79A
11platelet alpha granule lumenGO:03109311.9SERPINF2, SERPINA1, SERPING1, VEGFA, FIGF, FGB

Biological processes related to hepatitis c according to GeneDecks:

(show top 50)    (show all 71)
idNameGO IDScoreTop Affiliating Genes
1immune responseGO:00695524.5NCR3, CNR2, KIR2DS5, KIR2DL1, KIR2DL3, KIR3DS1
2signal transductionGO:00716524.0PI4KA, PIK3CB, PIK3CD, PI4KB, LRP8, PDCD1
3innate immune responseGO:04508723.7PIK3CD, PIK3CG, PIN1, PIK3C3, RELA, PCBP2
4virus-host interactionGO:01904823.1PIK3R1, RELA, RB1, SEPT6, VIM, VCAM1
5response to virusGO:00961521.9PCBP2, MYD88, BECN1P1, CHUK, MX1, MX2
6apoptotic processGO:00691521.2PDCD1, VIM, RAF1, BID, PAK1, PAK2
7blood coagulationGO:00759619.7PIK3CB, PIK3CA, PIK3R3, PIK3R2, PIK3R1, PIK3R5
8inflammatory responseGO:00695419.6PIK3CD, PIK3CG, NCR3, RELA, CNR2, SELE
9positive regulation of transcription from RNA polymerase II promoterGO:04594418.9PIAS2, RELA, RB1, SERPINF2, VEGFA, VDR
10type I interferon-mediated signaling pathwayGO:06033718.5USP18, MX1, MX2, JAK1, ISG15, ISG20
11gene expressionGO:01046717.8PCBP2, VDR, MYC, PARP1, PATL1, YWHAB
12cell-cell signalingGO:00726717.2NAMPT, CD86, CD80, ISG15, AR, INS
13cell surface receptor signaling pathwayGO:00716616.9BSG, MYD88, LILRA1, LEPR, LAG3, CD28
14positive regulation of transcription, DNA-dependentGO:04589316.8PIAS2, PIAS1, RELA, RB1, MYC, MYB
15positive regulation of cell proliferationGO:00828416.6CNTF, VIPR1, NAMPT, VEGFA, MYC, KDR
16response to drugGO:04249316.5REN, SEMA3C, LPL, MYC, BCHE, BCL2
17regulation of immune responseGO:05077616.0KIR3DL2, KIR2DL1, KIR2DL3, KIR2DL4, KIR3DL1, KIR2DS2
18induction of apoptosisGO:00691715.7BCL2L11, CIDEB, MX1, LCK, BAD, BAX
19chemotaxisGO:00693515.5PIK3CB, FGF2, IL4, ENPP2, MAPK14, MAPK1
20positive regulation of apoptotic processGO:04306515.1PIAS4, CNR1, SFRP4, BID, BCL2L11, BCL6
21protein phosphorylationGO:00646814.9PIK3CD, VRK1, BRAF, RAF1, PAK1, PAK2
22T cell costimulationGO:03129514.7PIK3CA, PIK3R3, PIK3R2, PIK3R1, PDCD1, BTLA
23response to lipopolysaccharideGO:03249614.6CNR1, CNR2, SELE, SELP, SERPINA1, UGT1A1
24Toll signaling pathwayGO:00806314.4RELA, MYD88, CHUK, UBC, JUN, CD14
25toll-like receptor 4 signaling pathwayGO:03414214.3RELA, MYD88, CHUK, UBC, JUN, CD14
26regulation of type I interferon-mediated signaling pathwayGO:06033814.0USP18, JAK1, IFNA10, IFNA13, IFNA14, IFNA16
27calcium-independent cell-cell adhesionGO:01633814.0CLDN16, CLDN17, CLDN2, CLDN22, CLDN4, CLDN5
28toll-like receptor 3 signaling pathwayGO:03413813.9RELA, CHUK, UBC, JUN, CD14, FOS
29TRIF-dependent toll-like receptor signaling pathwayGO:03566613.9RELA, CHUK, UBC, JUN, CD14, FOS
30anti-apoptosisGO:00691613.9PIK3CA, RELA, BRAF, MYD88, BCL2, BCL2L1
31agingGO:00756813.8CNR1, VDR, VCAM1, FURIN, JUN, ASS1
32T cell receptor signaling pathwayGO:05085213.7PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, RELA
33MyD88-independent toll-like receptor signaling pathwayGO:00275613.7RELA, CHUK, UBC, JUN, FOS, IRF3
34toll-like receptor signaling pathwayGO:00222413.6RELA, MYD88, CHUK, UBC, JUN, CD86
35nerve growth factor receptor signaling pathwayGO:04801113.6PIK3CB, PIK3CA, PIK3R2, PIK3R1, RELA, BRAF
36MyD88-dependent toll-like receptor signaling pathwayGO:00275513.5RELA, MYD88, CHUK, UBC, JUN, FOS
37response to organic cyclic compoundGO:01407013.4SELP, SERPINA1, UGT1A1, JUN, CDKN1A, CD83
38cellular response to mechanical stimulusGO:07126013.4MYD88, BAD, CD40, ITGB1, IRF1, IL13
39positive regulation of NF-kappaB transcription factor activityGO:05109213.4RELA, MYD88, CHUK, UBC, CD40, IRAK3
40platelet degranulationGO:00257613.3SELP, SERPINF2, SERPINA1, SERPING1, VEGFA, CD36
41lipopolysaccharide-mediated signaling pathwayGO:03166313.3MYD88, SCARB1, IRF3, IL18, IL1B, MAPK3
42leukocyte migrationGO:05090013.1PIK3CB, PIK3CA, PIK3R2, PIK3R1, SELP, BSG
43toll-like receptor 1 signaling pathwayGO:03413013.1RELA, MYD88, CHUK, UBC, JUN, FOS
44toll-like receptor 2 signaling pathwayGO:03413413.1RELA, MYD88, CHUK, UBC, JUN, FOS
45activation of pro-apoptotic gene productsGO:00863313.1MYC, BID, BCL2, BCL2L11, YWHAB, BAD
46insulin receptor signaling pathwayGO:00828612.8PIK3CB, PIK3CA, PIK3R3, PIK3R2, PIK3R1, PIK3C3
47response to ethanolGO:04547112.7CNR1, RBP4, BCL2, FYN, CD27, MMP9
48fibroblast growth factor receptor signaling pathwayGO:00854312.1PIK3CA, PIK3R1, BRAF, RAF1, CHUK, YWHAB
49response to estradiol stimulusGO:03235512.0SFRP4, SERPINA1, VDR, BID, AURKA, MMP15
50positive regulation of peptidyl-tyrosine phosphorylationGO:05073111.9LRP8, VEGFA, PAK2, MTOR, CD36, CD81

Molecular functions related to hepatitis c according to GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551560.2PI4KA, PIK3CB, PIK3CD, PIAS2, PIK3CA, PIAS3
2ATP bindingGO:00552422.5PI4KA, PIK3CB, PIK3CD, PIK3CA, PI4KB, PIK3CG
3cytokine activityGO:00512518.7CNTF, NAMPT, VEGFA, BMP6, BMP8A, BMP8B
4identical protein bindingGO:04280218.3RELA, PCNA, VIM, MYD88, RAF1, RASSF1
5protein homodimerization activityGO:04280317.7SERPINF2, VEGFA, VAPB, BCL2, SCARB1, CHEK2
6receptor activityGO:00487215.4KIR2DL1, KIR2DL3, BTLA, SEMA3C, LILRA2, LILRA3
7protein heterodimerization activityGO:04698214.7BRAF, VEGFA, VAPA, VAPB, MYC, BMP6
8transmembrane signaling receptor activityGO:00488814.4LRP8, KIR2DL4, KIR2DS2, KIR2DS1, SELE, LILRA1
9enzyme bindingGO:01989914.3PIAS3, PIAS1, PCBP2, VAPB, BLZF1, BCHE
10growth factor activityGO:00808314.1CNTF, VEGFA, BMP6, BMP8A, BMP8B, LEP
11ubiquitin protein ligase bindingGO:03162513.4PIAS2, PIAS4, RELA, PCBP2, RB1, BLZF1
12protein kinase activityGO:00467213.1PIK3CG, PIK3C3, BRAF, RAF1, PAK1, PAK2

Sources for Hepatitis C

about this section
2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
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