NANBH
MCID: HPT001
MIFTS: 66

Hepatitis C (NANBH) malady

Liver diseases category

Summaries for Hepatitis C

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Sources:
8Disease Ontology, 33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Your liver is the largest organ inside your body. it helps your body digest food, store energy, and remove poisons. hepatitis is an inflammation of the liver. one type, hepatitis c, is caused by the hepatitis c virus (hcv). it usually spreads through contact with infected blood. it can also spread through sex with an infected person and from mother to baby during childbirth. most people who are infected with hepatitis c don't have any symptoms for years. if you do get symptoms, you may feel as if you have the flu. you may also have jaundice, a yellowing of skin and eyes, dark-colored urine, and pale bowel movements. a blood test can tell if you have it. usually, hepatitis c does not get better by itself. the infection can last a lifetime and may lead to scarring of the liver or liver cancer. medicines sometimes help, but side effects can be a problem. serious cases may need a liver transplant. there is no vaccine for hcv. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Hepatitis C, also known as hepatitis c infection, is related to hepatitis and hepatitis a, and has symptoms including joint pain, jaundice and abdominal pain. An important gene associated with Hepatitis C is SPG20 (spastic paraplegia 20 (Troyer syndrome)), and among its related pathways is Hepatitis C. The drugs hepatitis c virus ns3/4a protease inhibitor [epc] and interferon alfa-2a have been mentioned in the context of this disorder. Affiliated tissues include liver, liver and t cells.

Disease Ontology:8 A viral infectious disease that results in inflammation located in liver, has material basis in hepatitis c virus, which is transmitted by blood from an infected person enters the body of an uninfected person. the infection has symptom fever, has symptom fatigue, has symptom loss of appetite, has symptom nausea, has symptom vomiting, has symptom abdominal pain, has symptom clay-colored bowel movements, has symptom joint pain, and has symptom jaundice.

Wikipedia:63 Hepatitis C is an infectious disease affecting primarily the liver, caused by the hepatitis C virus... more...

Aliases & Classifications for Hepatitis C

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 27ICD9CM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Liver diseases


Aliases & Descriptions:

hepatitis c 8 10 44 33 60
hepatitis c infection 8
hepatitis c, chronic 60
chronic hepatitis c 8
hepatitis nona nonb 8
hepatitis c chronic 44
viral hepatitis c 8
nanbh 8


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Disease Ontology8 DOID:1883
NCIt39 C3098
MeSH34 D006526
ICD9CM27 070.7

Related Diseases for Hepatitis C

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Hepatitis C:



Diseases related to hepatitis c

Clinical Features for Hepatitis C

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Sources:
8Disease Ontology
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Symptoms:

8 (show all 9)
  • joint pain
  • jaundice
  • abdominal pain
  • fatigue
  • loss of appetite
  • nausea
  • fever
  • clay-colored bowel movements
  • vomiting

Drugs & Therapeutics for Hepatitis C

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Hepatitis C

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Anatomical Context for Hepatitis C

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Hepatitis C:

32
Liver, T cells, Kidney, Testes, Thyroid, B cells, Skin, Eye, Monocytes, Bone, Endothelial, Nk cells, Bone marrow, Heart, Brain, Myeloid, Lymph node, Tongue, Whole blood, Pancreatic islet, Pituitary, Breast, Colon, Salivary gland, Lung, Spinal cord, Cortex, Prostate, Smooth muscle, Adrenal cortex, Thymus, Spleen

FMA organs/tissues related to Hepatitis C:

14
Liver

Animal Models for Hepatitis C or affiliated genes

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Publications for Hepatitis C

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Sources:
50PubMed
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Articles related to Hepatitis C:

(show top 50)    (show all 6107)
idTitleAuthorsYear
1
Treatment of hepatitis C with an interferon-based lead-in phase: a perspective from mathematical modelling. (24434478)
2014
2
Is acupuncture a risk factor for hepatitis C virus infection? (23956380)
2013
3
Prevalence of active hepatitis C virus infections among general public of Lahore, Pakistan. (24308812)
2013
4
The current hepatitis C virus prevalence in China may have resulted mainly from an officially encouraged plasma campaign in the 1990s: a coalescence inference with genetic sequences. (23986603)
2013
5
Effects of Sofosbuvir-based Treatment, With and Without Interferon, on Outcome and Productivity of Patients With Chronic Hepatitis C. (24316172)
2013
6
Sofosbuvir (GS-7977), a pan-genotype, direct-acting antiviral for hepatitis C virus infection. (24215243)
2013
7
A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus. (23291588)
2013
8
Prevalence of hepatitis C virus mutants resistant to protease inhibitors among Polish HCV genotype 1-infected patients. (24340552)
2013
9
A novel helper-dependent adenovirus-based cell culture model for Hepatitis C virus replication and production. (23987099)
2013
10
Hepatitis-B virus infection predicts mortality of HIV and hepatitis C virus coinfected patients. (23380966)
2013
11
Relationship of I+-fetoprotein levels and development of hepatocellular carcinoma in hepatitis C patients with liver cirrhosis. (23226758)
2012
12
Occult hepatitis B virus infection in patients with chronic hepatitis C treated with antiviral therapy. (23300497)
2012
13
Coeliac disease and C virus-related chronic hepatitis: a non association. (23009068)
2012
14
Viral hepatitis: Mechanism of fatigue in patients with chronic hepatitis C involves carnitine. (21544059)
2011
15
Transforming growth factor I^1 polymorphisms and progression of graft fibrosis after liver transplantation for hepatitis C virus--induced liver disease. (21384510)
2011
16
The potential role of insulin-like growth factor 1, insulin-like growth factor binding protein 3 and bone mineral density in patients with chronic hepatitis C virus in Cairo, Egypt. (20189618)
2010
17
2',5'-Oligoadenylate synthetase-like gene highly induced by hepatitis C virus infection in human liver is inhibitory to viral replication in vitro. (20074559)
2010
18
The SR-BI partner PDZK1 facilitates hepatitis C virus entry. (20949066)
2010
19
Splicing diversity of the human OCLN gene and its biological significance for hepatitis C virus entry. (20463075)
2010
20
Safety of atazanavir in patients with HIV and hepatitis B and/or C virus coinfection]. (20116617)
2008
21
Human butyrate-induced transcript 1 interacts with hepatitis C virus NS5A and regulates viral replication. (18160438)
2008
22
Therapeutic effect of ARBs on insulin resistance and liver injury in patients with NAFLD and chronic hepatitis C: a pilot study. (18813860)
2008
23
Primary liver sarcoma in an immunocompetent patient with hepatitis C virus infection. (18391609)
2008
24
Tolerability of Peg interferon-alpha2b and Ribavirin therapy in patients with chronic hepatitis C and glucose-6-phosphate dehydrogenase deficiency. (17107736)
2007
25
Monocyte-derived dendritic cell function in chronic hepatitis C is impaired at physiological numbers of dendritic cells. (17362265)
2007
26
Management of recurrent hepatitis C in liver transplant recipients. (16527654)
2006
27
The natural history of hepatitis C virus infection in Italian patients with von Willebrand's disease: a cohort study. (16585016)
2006
28
Regulating intracellular antiviral defense and permissiveness to hepatitis C virus RNA replication through a cellular RNA helicase, RIG-I. (15708988)
2005
29
Roles of protein kinase C and fructose in hepatic injury caused by obstructive jaundice. (16196296)
2005
30
Hepatic CD1d expression in hepatitis C virus infection and recognition by resident proinflammatory CD1d-reactive T cells. (15265953)
2004
31
UDP-glucuronosyltransferase 1A7 genetic polymorphisms are associated with hepatocellular carcinoma in japanese patients with hepatitis C virus infection. (15073122)
2004
32
Management of recurrence of hepatitis C infection following liver transplantation. (14603150)
2003
33
Hepatitis C virus proteins do not directly trigger fibrogenic events in cultured human liver myofibroblasts. (14633175)
2003
34
Hepatitis C virus non-structural protein 4 suppresses Th1 responses by stimulating IL-10 production from monocytes. (14635055)
2003
35
Effect of tumour necrosis factor alpha antagonists on serum transaminases and viraemia in patients with rheumatoid arthritis and chronic hepatitis C infection. (14583571)
2003
36
Expression of the costimulatory CD28 antigen on peripheral blood CD8+ T lymphocytes in patients with chronic hepatitis C]. (11887352)
2002
37
A multicentre, randomized study to evaluate the safety and efficacy of histamine dihydrochloride and interferon-alpha-2b for the treatment of chronic hepatitis C. (12225329)
2002
38
Treatment of chronic hepatitis C with amantadine hydrochloride in patients who had not responded to previous treatment with interferon-alpha and/or ribavirin. (11229855)
2001
39
Enhancing B- and T-cell immune response to a hepatitis C virus E2 DNA vaccine by intramuscular electrical gene transfer. (11090158)
2000
40
Chemokine and chemokine receptor interactions provide a mechanism for selective T cell recruitment to specific liver compartments within hepatitis C-infected liver. (10570316)
1999
41
Tumor necrosis factor alpha promoter polymorphism at position -238 is associated with chronic active hepatitis C infection. (9515764)
1998
42
Hepatic expression of c-Myb in chronic human liver disease. (9397991)
1997
43
Distal gangrene and cryoglobulinemia related to hepatitis C virus infection with presence of anticardiolipin antibodies]. (9161561)
1997
44
Development and exacerbation of oral lichen planus during and after interferon therapy for hepatitis C. (9013095)
1996
45
A hyperimmune serum against a synthetic peptide corresponding to the hypervariable region 1 of hepatitis C virus can prevent viral infection in cell cultures. (8806581)
1996
46
Serum interleukin 2 and soluble interleukin 2 receptor in chronic active hepatitis C: effect of interferon therapy. (8725984)
1996
47
Alpha interferon treatment of chronic hepatitis C. (7647281)
1995
48
SjAPgren's syndrome without mixed cryoglobulinemia is not associated with hepatitis C virus infection. (7517099)
1994
49
Membranoproliferative glomerulonephritis and micronodular cirrhosis associated with hepatitis C virus infection in a chronically transfused sickle cell patient. (8172192)
1994
50
Effect of alpha-interferon on hepatitis C virus chronic infection in mixed cryoglobulinemia patients. (7684029)
1993

Genetic Variations for Hepatitis C

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Expression for genes affiliated with Hepatitis C

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hepatitis C

Search GEO for disease gene expression data for Hepatitis C.

Pathways for genes affiliated with Hepatitis C

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29KEGG
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Pathways related to Hepatitis C according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.0CLDN6, CLDN9, SCARB1

Compounds for genes affiliated with Hepatitis C

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GO Terms for genes affiliated with Hepatitis C

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16Gene Ontology
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Biological processes related to Hepatitis C according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1modulation by virus of host morphology or physiologyGO:01904810.9ACY3, DDX3X, SCARB1, PSMA7
2calcium-independent cell-cell adhesionGO:01633810.9CLDN6, CLDN9

Molecular functions related to Hepatitis C according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:04280211.2ACY3, CLDN6, CLDN9, PSMA7

Products for genes affiliated with Hepatitis C

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hepatitis C

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet