NANBH
MCID: HPT001
MIFTS: 66

Hepatitis C (NANBH) malady

Liver category

Summaries for Hepatitis C

Sources:
8Disease Ontology, 34MedlinePlus, 64Wikipedia, 33MalaCards
See all sources

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MedlinePlus:34 Your liver is the largest organ inside your body. it helps your body digest food, store energy, and remove poisons. hepatitis is an inflammation of the liver. one type, hepatitis c, is caused by the hepatitis c virus (hcv). it usually spreads through contact with infected blood. it can also spread through sex with an infected person and from mother to baby during childbirth. most people who are infected with hepatitis c don't have any symptoms for years. if you do get symptoms, you may feel as if you have the flu. you may also have jaundice, a yellowing of skin and eyes, dark-colored urine, and pale bowel movements. a blood test can tell if you have it. usually, hepatitis c does not get better by itself. the infection can last a lifetime and may lead to scarring of the liver or liver cancer. medicines sometimes help, but side effects can be a problem. serious cases may need a liver transplant. there is no vaccine for hcv. nih: national institute of diabetes and digestive and kidney diseases

MalaCards: Hepatitis C, also known as hepatitis c infection, is related to hepatitis a and hepatitis c virus, and has symptoms including fever, fatigue and loss of appetite. An important gene associated with Hepatitis C is SPG20 (spastic paraplegia 20 (Troyer syndrome)), and among its related pathways is Hepatitis C. The drugs hepatitis c virus ns3/4a protease inhibitor [epc] and interferon alfa-2a have been mentioned in the context of this disorder. Affiliated tissues include liver, liver and bone marrow.

Disease Ontology:8 A viral infectious disease that results in inflammation located in liver, has material basis in hepatitis c virus, which is transmitted by blood from an infected person enters the body of an uninfected person. the infection has symptom fever, has symptom fatigue, has symptom loss of appetite, has symptom nausea, has symptom vomiting, has symptom abdominal pain, has symptom clay-colored bowel movements, has symptom joint pain, and has symptom jaundice.

Wikipedia:64 Hepatitis C is an infectious disease affecting primarily the liver, caused by the hepatitis C virus... more...

Aliases & Classifications for Hepatitis C

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 57SNOMED-CT, 40NCIt, 35MeSH, 27ICD9CM
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Liver


Aliases & Descriptions:

hepatitis c 8 10 45 34 61
hepatitis c infection 8
hepatitis c, chronic 61
chronic hepatitis c 8
hepatitis nona nonb 8
hepatitis c chronic 45
viral hepatitis c 8
nanbh 8


External Ids:

Disease Ontology8 DOID:1883
NCIt40 C3098
MeSH35 D006526
ICD9CM27 070.7

Related Diseases for Hepatitis C

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Hepatitis C family:

hepatitis e hepatitis b
autoimmune hepatitis hepatitis d
hepatitis a hepatitis
viral hepatitis hepatitis c virus

Diseases related to Hepatitis C via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 338)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis a11.6
2hepatitis c virus11.6
3hepatitis e11.5
4hepatitis d11.5
5hepatitis b11.3
6viral hepatitis11.2
7cryoglobulinemia11.1
8hepatitis b virus infection10.9
9porphyria cutanea tarda10.8
10insulin resistance10.8
11autoimmune hepatitis10.8
12membranoproliferative glomerulonephritis10.8
13lichen planus10.7
14vasculitis10.7
15alcoholic hepatitis10.6
16oral lichen planus10.6
17hemophilia10.6
18thrombocytopenia10.6
19thyroiditis10.6
20hemochromatosis10.5
21thalassemia10.5
22non-a-e hepatitis10.5
23nonalcoholic steatohepatitis10.5
24arthritis10.5
25membranous glomerulonephritis10.4
26autoimmune thyroiditis10.4
27fatty liver disease10.4
28autoimmune hemolytic anemia10.4
29liver lymphoma10.4
30syphilis10.4
31polyarteritis nodosa10.3
32sialadenitis10.3
33primary effusion lymphoma10.3
34vogt-koyanagi-harada disease10.3
35hypersplenism10.3
36n syndrome10.3
37alopecia10.3
38beta thalassemia10.3
39alopecia universalis10.3
40ischemic neuropathy10.3
41ischemic optic neuropathy10.3
42alcoholic liver cirrhosis10.3
43splenic marginal zone lymphoma10.3
44chronic end-stage hepatitis c10.2
45antiphospholipid syndrome10.2
46autoimmune thrombocytopenic purpura10.2
47myelitis10.2
48primary biliary cirrhosis10.2
49thrombotic thrombocytopenic purpura10.2
50portal hypertension10.2

Graphical network of the top 20 diseases related to Hepatitis C:



Diseases related to hepatitis c

Clinical Features for Hepatitis C

Sources:
8Disease Ontology
See all sources


Symptoms:

8 (show all 9)
  • fever
  • fatigue
  • loss of appetite
  • nausea
  • vomiting
  • abdominal pain
  • clay-colored bowel movements
  • joint pain
  • jaundice

Drugs & Therapeutics for Hepatitis C

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Genetic Tests for Hepatitis C

Anatomical Context for Hepatitis C

Sources:
14FMA, 33MalaCards
See all sources

MalaCards organs/tissues related to Hepatitis C:

33
Liver, Bone marrow, Whole blood, Lymph node, Spleen, Thymus, Brain, Cortex, Spinal cord, Heart, Smooth muscle, Small intestine, Colon, Kidney, Lung, Pancreas, Thyroid, Salivary gland, Adrenal gland, Breast, Skin, Prostate, Myeloid, Monocytes, Nk cells, T cells, B lymphoblasts, B cells, Endothelial, Fetal brain, Parietal lobe, Temporal lobe, Hypothalamus, Caudate nucleus, Tongue, Fetal liver, Fetal lung, Fetal thyroid, Pancreatic islet, Adrenal cortex, Pituitary

FMA organs/tissues related to Hepatitis C:

14
Liver

Animal Models for Hepatitis C or affiliated genes

Sources:
28inGenious Targeting Laboratory
See all sources

Publications for Hepatitis C

Sources:
51PubMed
See all sources

Articles related to Hepatitis C:

(show top 50)    (show all 9793)
idTitleAuthorsYear
1
Transient replication of a hepatitis C virus genotype 1b replicon chimera encoding NS5A-5B from genotype 3a. (24120570)
2014
2
Early increased ficolin-2 concentrations are associated with severity of liver inflammation and efficacy of anti-viral therapy in chronic hepatitis C patients. (23298162)
2013
3
Association between chronic hepatitis C virus infection and high levels of circulating N-terminal pro-brain natriuretic peptide. (22581254)
2013
4
Inhibition of hepatitis C virus by the cyanobacterial protein Microcystis viridis lectin: mechanistic differences between the high-mannose specific lectins MVL, CV-N, and GNA. (24152340)
2013
5
Entecavir and intermittent etanercept therapy in a patient with concurrent hepatitis B virus infection and psoriasis. (23147755)
2013
6
Inhibition of Hepatitis C Virus Production by Aptamer for Core Protein. (24307579)
2013
7
Regulatory T cells and autoimmune hepatitis: defective cells or a hostile environment? (22522382)
2012
8
Antibody persistence and immune memory in adults, 15 years after a three-dose schedule of a combined hepatitis A and B vaccine. (22052690)
2012
9
Importance of the cutoff ratio for detecting antibodies against hepatitis A virus in oral fluids by enzyme immunoassay. (21295610)
2011
10
Influence of interleukin-28B single-nucleotide polymorphisms on progression to liver cirrhosis in human immunodeficiency virus-hepatitis C virus-coinfected patients receiving antiretroviral therapy. (21592993)
2011
11
High incidence of hepatitis B infection-associated cirrhosis and hepatocellular carcinoma in the Southeast Asian patients with portal vein thrombosis. (21658275)
2011
12
Pathogenesis of occult chronic hepatitis B virus infection. (21472118)
2011
13
Clinical significance of occult hepatitis B virus infection. (21472119)
2011
14
Circulating microRNAs, miR-21, miR-122, and miR-223, in patients with hepatocellular carcinoma or chronic hepatitis. (21229610)
2011
15
Seroprevalence rates of Helicobacter pylori and viral hepatitis A among adolescents in three regions of the Kingdom of Saudi Arabia: is there any correlation? (21073610)
2010
16
Effect of dipterinyl calcium pentahydrate on hepatitis B virus replication in transgenic mice. (20356392)
2010
17
Expression of estrogen receptor I+ in hepatitis B-related hepatocellular carcinoma and its clinical significance]. (21211272)
2010
18
Expression of contactin associated protein-like 2 in a subset of hepatic progenitor cell compartment identified by gene expression profiling in hepatitis B virus-positive cirrhosis. (19889080)
2010
19
The haplotype of the MxA gene promoter is associated with hepatitis B virus infection in a Chinese population. (19744071)
2009
20
Induction of SMYD3 by hepatitis B virus X gene in HepG2 cells]. (19403031)
2009
21
Acute pancreatitis--complicating hepatitis E virus infection in a 7-year-old boy with glucose 6 phosphate dehydrogenase deficiency. (19129425)
2009
22
Anti-cyclic citrullinated peptide antibodies distinguish hepatitis B virus (HBV)-associated arthropathy from concomitant rheumatoid arthritis in patients with chronic HBV infection. (19286846)
2009
23
Clinical, biochemical, immunological and virological profiles of, and differential diagnosis between, patients with acute hepatitis B and chronic hepatitis B with acute flare. (18823435)
2008
24
Skew in T cell receptor usage with polyclonal expansion in lesions of oral lichen planus without hepatitis C virus infection. (18782324)
2008
25
Dynamic expression of PD-1 in HBV-specific cytotoxic T lymphocytes correlates with memory T-cell development in acute hepatitis B patients]. (18822202)
2008
26
MicroRNAome of splenic macrophages in hypersplenism due to portal hypertension in hepatitis B virus-related cirrhosis. (18791127)
2008
27
Comparison of the efficacy of thymosin alpha-1 and interferon alpha in the treatment of chronic hepatitis B: a meta-analysis. (18078676)
2008
28
Interferon-alpha treatment in children and young adults with chronic hepatitis B: a long-term follow-up study in Taiwan. (18397229)
2008
29
Genetic polymorphisms of MxA protein and eIF-2a-reg2 and their responses to interferon treatment in patients with chronic hepatitis B]. (17407708)
2007
30
Lack of higher frequency of the chemokine receptor 5-delta32/delta32 genotype in hepatitis C. (16721228)
2006
31
Efficacy of lamivudine in the treatment of children with chronic hepatitis B. (15799860)
2005
32
An intensive surveillance program detected a high incidence of hepatocellular carcinoma among hepatitis B virus carriers with abnormal alpha-fetoprotein levels or abdominal ultrasonography results. (16258102)
2005
33
Enhanced TH1 cytokine production in hepatitis C virus-infected patients with mixed cryoglobulinemia: understanding the pathological issues. (15582141)
2004
34
Combinatorial control of human RNA polymerase II (RNAP II) pausing and transcript cleavage by transcription factor IIF, hepatitis delta antigen, and stimulatory factor II. (14506279)
2003
35
Interleukin-1, interleukin-10 and tumour necrosis factor-alpha gene polymorphisms in hepatitis C virus infection: an investigation of the relationships with spontaneous viral clearance and response to alpha-interferon therapy. (12390476)
2002
36
Expression of cyclooxygenase-2 in chronic hepatitis B and the effects of anti-viral therapy. (11860408)
2002
37
The characteristics of clinical course of chronic hepatitis B and liver cirrhosis pathology of child patient]. (11503051)
2000
38
Human leukocyte antigen class II and III alleles and severity of hepatitis C virus-related chronic liver disease. (10094975)
1999
39
Analysis of T-cell receptor Vbeta repertoire in liver-infiltrating lymphocytes in chronic hepatitis C. (9075650)
1997
40
A randomized controlled trial of thymosin-alpha1 versus interferon alfa treatment in patients with hepatitis B e antigen antibody--and hepatitis B virus DNA--positive chronic hepatitis B. (8855175)
1996
41
Interferon alfa in the treatment of chronic hepatitis C: course of 24 versus 48 weeks. Results of a randomized trial]. (9180949)
1996
42
Immunosuppression may lead to progression of hepatitis C virus-associated liver disease in hemophiliacs coinfected with HIV. (8946987)
1996
43
Serum lipid levels during interferon therapy in patients with chronic hepatitis C. (8528942)
1995
44
High prevalence of serological markers of autoimmunity in patients with chronic hepatitis C. (7533120)
1995
45
Behavior of soluble HLA class I antigens in patients with chronic hepatitis C during interferon therapy: an early predictor marker of response? (7593464)
1995
46
Clinical study on long-term treatment of chronic hepatitis C with interferon]. (1904507)
1991
47
Serological markers of hepatitis B virus and hepatitis D virus infections in Greek adults with primary hepatocellular carcinoma. (2537800)
1989
48
Acalculous cholecystitis as a complication of hepatitis. (3297702)
1987
49
Hepatitis B-associated membranous glomerulonephritis in a child. (391021)
1979
50
A case of the Dubin-Johnson syndrome complicated by acute hepatitis. (5485831)
1970

Genetic Variations for Hepatitis C

Expression for genes affiliated with Hepatitis C

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Hepatitis C

Search GEO for disease gene expression data for Hepatitis C.

Pathways for genes affiliated with Hepatitis C

Sources:
30KEGG
See all sources

Pathways related to Hepatitis C according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.0CLDN6, CLDN9, SCARB1

Compounds for genes affiliated with Hepatitis C

GO Terms for genes affiliated with Hepatitis C

Sources:
16Gene Ontology
See all sources

Biological processes related to Hepatitis C according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1modulation by virus of host morphology or physiologyGO:01904810.9ACY3, DDX3X, SCARB1, PSMA7
2calcium-independent cell-cell adhesionGO:01633810.9CLDN6, CLDN9

Molecular functions related to Hepatitis C according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:04280211.2ACY3, CLDN6, CLDN9, PSMA7

Products for genes affiliated with Hepatitis C

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hepatitis C

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet