MCID: HPT073
MIFTS: 48

Hepatitis C Virus malady

Rare diseases, Gastrointestinal diseases, Liver diseases, Immune diseases, Infectious diseases categories
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Summaries for Hepatitis C Virus

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MalaCards based summary: Hepatitis C Virus is related to hepatitis c and hepatitis. An important gene associated with Hepatitis C Virus is CCR5 (chemokine (C-C motif) receptor 5 (gene/pseudogene)), and among its related pathways are Cell adhesion molecules (CAMs) and Hepatitis C. The compound lutein have been mentioned in the context of this disorder. Affiliated tissues include liver, t cells and b cells.

Description from OMIM:46 609532

Aliases & Classifications for Hepatitis C Virus

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Hepatitis C Virus, Aliases & Descriptions:

Name: Hepatitis C Virus 46


Classifications:



Related Diseases for Hepatitis C Virus

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Diseases in the Hepatitis C family:

Autoimmune Hepatitis Hepatitis
Hepatitis B Hepatitis D
Hepatitis a Hepatitis E
Viral Hepatitis hepatitis c virus
Susceptibility to Hepatitis Due to Voriconazole Treatment Susceptibility to Hepatitis Due to Flucloxacilline Treatment

Diseases related to Hepatitis C Virus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 277)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis c32.9CCR5, SCARB1, DDX3X
2hepatitis11.9
3cryoglobulinemia11.3
4hepatocellular carcinoma11.2
5liver disease11.0
6glomerulonephritis11.0
7hepatitis b11.0
8porphyria cutanea tarda10.9
9porphyria10.9
10membranoproliferative glomerulonephritis10.9
11vasculitis10.9
12liver cirrhosis10.8
13insulin resistance10.8
14lichen planus10.8
15oral lichen planus10.7
16b-cell lymphomas10.7
17type ii mixed cryoglobulinemia10.7
18hepatitis b virus infection10.7
19arthritis10.6
20cholangiocarcinoma10.6
21hodgkin's lymphoma10.6
22leukemia10.6
23thyroiditis10.6
24thrombocytopenia10.6
25hepatitis d10.6
26membranous glomerulonephritis10.6
27kidney disease10.6
28hemophilia10.6
29alcoholic hepatitis10.5
30hiv-110.5
31thalassemia10.5
32liver cancer10.5
33viral hepatitis10.5
34nonalcoholic steatohepatitis10.5
35primary effusion lymphoma10.5
36hemolytic anemia10.5
37hemochromatosis10.5
38hepatitis a10.5
39intrahepatic cholangiocarcinoma10.5
40polyneuropathy10.5
41purpura10.5
42autoimmune hepatitis10.5
43autoimmune hemolytic anemia10.5
44hypersplenism10.5
45diarrhea10.5
46neuropathy10.5
47alcoholic liver cirrhosis10.4
48diffuse large b-cell lymphoma10.4
49hypertension10.4
50marginal zone b-cell lymphoma10.4

Graphical network of the top 20 diseases related to Hepatitis C Virus:



Diseases related to hepatitis c virus

Symptoms for Hepatitis C Virus

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Clinical features from OMIM:

609532

Drugs & Therapeutics for Hepatitis C Virus

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Drug clinical trials:

Search ClinicalTrials for Hepatitis C Virus

Search NIH Clinical Center for Hepatitis C Virus

Genetic Tests for Hepatitis C Virus

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Anatomical Context for Hepatitis C Virus

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MalaCards organs/tissues related to Hepatitis C Virus:

32
Liver, T cells, B cells, Kidney, Testes, Nk cells, Bone, Thyroid, Monocytes, Bone marrow, Endothelial, Lymph node, Myeloid, Whole blood, Brain, Heart, Skin, Eye, Spleen, Smooth muscle, Colon, Lung, Salivary gland, Breast, Tongue, Pancreatic islet

Animal Models for Hepatitis C Virus or affiliated genes

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Publications for Hepatitis C Virus

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Articles related to Hepatitis C Virus:

(show top 50)    (show all 3030)
idTitleAuthorsYear
1
Hepatocyte Nuclear Factor 4I+ and Downstream Secreted Phospholipase A2 GXIIB Regulate Production of Infectious Hepatitis C Virus. (24173221)
2014
2
How to optimize current treatment of genotype 2 hepatitis C virus infection. (24373073)
2014
3
The case for cost-effectively treating cryoglobulinemic vasculitis with interferon-free anti-hepatitis C virus therapy. (25380535)
2014
4
Septic bursitis, a potential complication of protease inhibitor use in hepatitis C virus. (23413416)
2013
5
Hepatitis C virus clearance correlates with HLA-DR expression on proliferating CD8+ T-cells in immune-primed chimpanzees. (24123114)
2013
6
Chronic hepatitis C virus infection is associated with all-cause and liver-related mortality in a cohort of HIV-infected patients with alcohol problems. (24112091)
2013
7
Subinfectious hepatitis C virus exposures suppress T cell responses against subsequent acute infection. (24270546)
2013
8
Activation of the connective tissue growth factor (CTGF)-transforming growth factor I^ 1 (TGF-I^ 1) axis in hepatitis C virus-expressing hepatocytes. (23056332)
2012
9
A zebrafish model of intrahepatic cholangiocarcinoma by dual expression of hepatitis B virus X and hepatitis C virus core protein in liver. (22729936)
2012
10
MAP-kinase regulated cytosolic phospholipase A2 activity is essential for production of infectious hepatitis C virus particles. (22911431)
2012
11
Hepatitis C virus infection suppresses GLUT2 gene expression via downregulation of hepatocyte nuclear factor 1I+. (22993150)
2012
12
Differential stimulation of hepatitis C virus RNA translation by microRNA-122 in different cell cycle phases. (22189820)
2012
13
Innate immune genes synergize to predict increased risk of chronic disease in hepatitis C virus infection. (21402922)
2011
14
HLA-C/KIR genotypes in oral lichen planus patients infected or non-infected with hepatitis C virus. (20860769)
2011
15
Host apolipoprotein B messenger RNA-editing enzyme catalytic polypeptide-like 3G is an innate defensive factor and drug target against hepatitis C virus. (21480314)
2011
16
Extracellular hepatitis C virus core protein activates STAT3 in human monocytes/macrophages/dendritic cells via an IL-6 autocrine pathway. (21282107)
2011
17
Interplay between NS3 protease and human La protein regulates translation-replication switch of Hepatitis C virus. (22355520)
2011
18
The ESCRT system is required for hepatitis C virus production. (21264300)
2011
19
IL28B, HLA-C, and KIR variants additively predict response to therapy in chronic hepatitis C virus infection in a European Cohort: a cross-sectional study. (21931540)
2011
20
Rituximab monotherapy, rather than rituximab plus antiviral drugs, for initial treatment of severe hepatitis C virus-associated mixed cryoglobulinemia syndrome: comment on the article by Terrier et al. (20131242)
2010
21
Aortic dissection caused by aortitis associated with hepatitis C virus-related cryoglobulinemia. (20728096)
2010
22
Enhanced hepatitis C virus genome replication and lipid accumulation mediated by inhibition of AMP-activated protein kinase. (20534540)
2010
23
Evaluation of the role of three candidate human kinases in the conversion of the hepatitis C virus inhibitor 2'-C-methyl-cytidine to its 5'-monophosphate metabolite. (19883694)
2010
24
The role of P-glycoprotein in the pharmacokinetics and tissue distribution of a hepatitis C virus protease inhibitor. (19995330)
2009
25
Hepatitis C virus receptor expression in normal and diseased liver tissue. (18085708)
2008
26
Hepatitis C virus infection in mouse hepatoma cells co-expressing human CD81 and Sip-L. (18474223)
2008
27
A novel, helminth-derived immunostimulant enhances human recall responses to hepatitis C virus and tetanus toxoid and is dependent on CD56+ cells for its action. (18341617)
2008
28
Hepatitis C virus NS5A protein interacts with and negatively regulates the non-receptor protein tyrosine kinase Syk. (18420802)
2008
29
Etiologic treatment of hepatitis C virus-associated mixed cryoglobulinemia. (17936209)
2007
30
Elevated serum levels of interferon- gamma -inducible protein-10 in patients coinfected with hepatitis C virus and HIV. (17763328)
2007
31
Serum-derived hepatitis C virus infectivity in interferon regulatory factor-7-suppressed human primary hepatocytes. (17112629)
2007
32
Analysis of mutations within the 5' untranslated region, interferon sensitivity region, and PePHD region as a function of response to interferon therapy in hepatitis C virus-infected patients in India. (16517843)
2006
33
Interferon-alpha suppresses liver cell proliferation in patients with chronic hepatitis C virus infection. (16108765)
2005
34
Binding of hepatitis C virus envelope protein E2 to CD81 up-regulates matrix metalloproteinase-2 in human hepatic stellate cells. (15611113)
2005
35
Effects of combined antiviral therapy on asymptomatic mixed cryoglobulinemia in naive patients with chronic hepatitis C virus infection: a preliminary study. (16416186)
2005
36
Treatment of chronic hepatitis C virus in allogeneic bone marrow transplant recipients. (16062173)
2005
37
Screening and cloning target genes transactivated by hepatitis C virus F protein using suppression subtractive hybridization technique. (16174453)
2005
38
Human VAP-B is involved in hepatitis C virus replication through interaction with NS5A and NS5B. (16227268)
2005
39
Structural biology of human CD81, a receptor for hepatitis C virus]. (15449903)
2004
40
Iron regulates hepatitis C virus translation via stimulation of expression of translation initiation factor 3. (15272411)
2004
41
Interleukin-1beta gene polymorphisms associated with hepatocellular carcinoma in hepatitis C virus infection. (12500190)
2003
42
Human leukocyte antigen class I and II alleles and response to interferon-alpha treatment, in Taiwanese patients with chronic hepatitis C virus infection. (12825172)
2003
43
Interferon responsiveness in patients infected with hepatitis C virus 1b differs depending on viral subtype. (11454804)
2001
44
The amino acid sequence of the PKR-eIF2alpha phosphorylation homology domain of hepatitis C virus envelope 2 protein and response to interferon-alpha. (11023475)
2000
45
Prevalence of hepatitis C virus associated cryoglobulinemia at a veterans hospital. (9375872)
1997
46
An atypical verrucous carcinoma of the tongue arising in a patient with oral lichen planus associated with hepatitis C virus infection. (9307733)
1997
47
Type of impaired porphyrin metabolism caused by hepatitis C virus is not porphyria cutanea tarda but chronic hepatic porphyria. (9301601)
1997
48
Diversity of quasispecies in various disease stages of chronic hepatitis C virus infection and its significance in interferon treatment. (7541387)
1995
49
Hepatitis C virus associated membranous glomerulonephritis. (8556829)
1995
50
Hepatitis C virus antibody titration in patients with chronic hepatitis C, before and after interferon treatment. (1279945)
1992

Variations for Hepatitis C Virus

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Clinvar genetic disease variations for Hepatitis C Virus:

6
id Gene Name Type Significance SNP ID Assembly Location
1PTPRCPTPRC, 77C-Gsingle nucleotide variantrisk factor

Expression for genes affiliated with Hepatitis C Virus

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Expression patterns in normal tissues for genes affiliated with Hepatitis C Virus

Search GEO for disease gene expression data for Hepatitis C Virus.

Pathways for genes affiliated with Hepatitis C Virus

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Pathways related to Hepatitis C Virus according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1CLDN9, CLDN6, PTPRC
210.1CLDN9, CLDN6, SCARB1

Compounds for genes affiliated with Hepatitis C Virus

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Sources:
44Novoseek
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Compounds related to Hepatitis C Virus according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1lutein4410.3PTPRC, SCARB1

GO Terms for genes affiliated with Hepatitis C Virus

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Biological processes related to Hepatitis C Virus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1calcium-independent cell-cell adhesionGO:01633810.2CLDN9, CLDN6
2viral processGO:0160329.6TBC1D20, ACY3, CCR5, SCARB1, DDX3X

Molecular functions related to Hepatitis C Virus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055159.4NOLC1, HDDC2, SPG20, SCARB1, PTPRC, MEMO1

Products for genes affiliated with Hepatitis C Virus

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  • Antibodies
  • Proteins
  • Lysates

Sources for Hepatitis C Virus

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet