MCID: HPT073
MIFTS: 51

Hepatitis C Virus malady

Genetic diseases, Liver diseases, Rare diseases, Gastrointestinal diseases, Infectious diseases categories

Aliases & Classifications for Hepatitis C Virus

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Hepatitis C Virus, Aliases & Descriptions:

Name: Hepatitis C Virus 45 22
Hepatitis C Virus Infection, Response to Therapy of 45
Hepatitis C Virus, Response to Therapy of 45
 
Hepatitic C Virus, Susceptibility to 10
Hepatitic C Virus 45


Classifications:



External Ids:

OMIM45 609532

Summaries for Hepatitis C Virus

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OMIM:45 HCV, which is principally transmitted by blood, infects about 3% of the world's population. HCV infection causes acute... (609532) more...

MalaCards based summary: Hepatitis C Virus, also known as hepatitis c virus infection, response to therapy of, is related to hepatitis c and hepatitis b. An important gene associated with Hepatitis C Virus is IFNL3 (interferon, lambda 3), and among its related pathways is B Cell Receptor Signaling Pathway. The compounds ribavirin and indinavir have been mentioned in the context of this disorder. Affiliated tissues include liver, t cells and b cells.

Related Diseases for Hepatitis C Virus

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Diseases in the Hepatitis family:

hepatitis c virus Autoimmune Hepatitis
Hepatitis B Hepatitis C
Hepatitis D Hepatitis a
Hepatitis E Viral Hepatitis

Diseases related to Hepatitis C Virus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 261)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis c33.1PTPRC, CCR5, IFNG
2hepatitis b31.8CCR5, IFNG
3schistosomiasis31.0IFNG, CCR5
4encephalitis30.6PTPRC, CCR5
5graves' disease30.4IFNG, CCR5, PTPRC
6influenza30.4IFNG, CCR5, PTPRC
7hepatitis11.8
8cryoglobulinemia11.2
9hepatocellular carcinoma11.1
10liver disease11.0
11glomerulonephritis11.0
12porphyria cutanea tarda10.9
13porphyria10.9
14membranoproliferative glomerulonephritis10.9
15vasculitis10.9
16liver cirrhosis10.8
17lichen planus10.8
18oral lichen planus10.7
19b-cell lymphomas10.7
20type ii mixed cryoglobulinemia10.6
21arthritis10.6
22cholangiocarcinoma10.6
23kidney disease10.6
24thyroiditis10.6
25leukemia10.5
26thrombocytopenia10.5
27membranous glomerulonephritis10.5
28hepatitis d10.5
29hemophilia10.5
30pleurisy10.5KIAA0101
31hiv-110.5
32alcoholic hepatitis10.5
33thalassemia10.5
34hepatitis a10.5
35intrahepatic cholangiocarcinoma10.5
36viral hepatitis10.5
37nonalcoholic steatohepatitis10.5
38primary effusion lymphoma10.5
39hemochromatosis10.5
40hemolytic anemia10.5
41polyarteritis nodosa10.5
42polyneuropathy10.5
43purpura10.5
44periapical granuloma10.5CCR5
45autoimmune hepatitis10.4
46diffuse large b-cell lymphoma10.4
47splenic marginal zone lymphoma10.4
48portal hypertension10.4
49autoimmune hemolytic anemia10.4
50hypersplenism10.4

Graphical network of the top 20 diseases related to Hepatitis C Virus:



Diseases related to hepatitis c virus

Symptoms for Hepatitis C Virus

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Clinical features from OMIM:

609532

Drugs & Therapeutics for Hepatitis C Virus

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Drug clinical trials:

Search ClinicalTrials for Hepatitis C Virus

Search NIH Clinical Center for Hepatitis C Virus

Genetic Tests for Hepatitis C Virus

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Genetic tests related to Hepatitis C Virus:

id Genetic test Affiliating Genes
1 Hepatitis C Virus, Susceptibility to22

Anatomical Context for Hepatitis C Virus

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MalaCards organs/tissues related to Hepatitis C Virus:

31
Liver, T cells, B cells, Kidney, Testes, Nk cells, Bone, Thyroid, Monocytes, Bone marrow, Endothelial, Lymph node, Myeloid, Whole blood, Brain, Heart, Skin, Eye, Spleen, Smooth muscle, Lung, Salivary gland, Breast, Tongue, Pancreatic islet

Animal Models for Hepatitis C Virus or affiliated genes

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Publications for Hepatitis C Virus

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Articles related to Hepatitis C Virus:

(show top 50)    (show all 3067)
idTitleAuthorsYear
1
MicroRNA-155 controls Toll-like receptor 3- and hepatitis C virus-induced immune responses in the liver. (24383923)
2014
2
Hepatocyte Nuclear Factor 4I+ and Downstream Secreted Phospholipase A2 GXIIB Regulate Production of Infectious Hepatitis C Virus. (24173221)
2014
3
How to optimize current treatment of genotype 2 hepatitis C virus infection. (24373073)
2014
4
Septic bursitis, a potential complication of protease inhibitor use in hepatitis C virus. (23413416)
2013
5
Hepatitis C virus clearance correlates with HLA-DR expression on proliferating CD8+ T-cells in immune-primed chimpanzees. (24123114)
2013
6
Chronic hepatitis C virus infection is associated with all-cause and liver-related mortality in a cohort of HIV-infected patients with alcohol problems. (24112091)
2013
7
Subinfectious hepatitis C virus exposures suppress T cell responses against subsequent acute infection. (24270546)
2013
8
Activation of the connective tissue growth factor (CTGF)-transforming growth factor I^ 1 (TGF-I^ 1) axis in hepatitis C virus-expressing hepatocytes. (23056332)
2012
9
A zebrafish model of intrahepatic cholangiocarcinoma by dual expression of hepatitis B virus X and hepatitis C virus core protein in liver. (22729936)
2012
10
MAP-kinase regulated cytosolic phospholipase A2 activity is essential for production of infectious hepatitis C virus particles. (22911431)
2012
11
Hepatitis C virus infection suppresses GLUT2 gene expression via downregulation of hepatocyte nuclear factor 1I+. (22993150)
2012
12
Differential stimulation of hepatitis C virus RNA translation by microRNA-122 in different cell cycle phases. (22189820)
2012
13
Innate immune genes synergize to predict increased risk of chronic disease in hepatitis C virus infection. (21402922)
2011
14
HLA-C/KIR genotypes in oral lichen planus patients infected or non-infected with hepatitis C virus. (20860769)
2011
15
Impact of viral amino acid substitutions and host interleukin-28b polymorphism on replication and susceptibility to interferon of hepatitis C virus. (21618576)
2011
16
Host apolipoprotein B messenger RNA-editing enzyme catalytic polypeptide-like 3G is an innate defensive factor and drug target against hepatitis C virus. (21480314)
2011
17
Extracellular hepatitis C virus core protein activates STAT3 in human monocytes/macrophages/dendritic cells via an IL-6 autocrine pathway. (21282107)
2011
18
Interplay between NS3 protease and human La protein regulates translation-replication switch of Hepatitis C virus. (22355520)
2011
19
The ESCRT system is required for hepatitis C virus production. (21264300)
2011
20
IL28B, HLA-C, and KIR variants additively predict response to therapy in chronic hepatitis C virus infection in a European Cohort: a cross-sectional study. (21931540)
2011
21
Rituximab monotherapy, rather than rituximab plus antiviral drugs, for initial treatment of severe hepatitis C virus-associated mixed cryoglobulinemia syndrome: comment on the article by Terrier et al. (20131242)
2010
22
Aortic dissection caused by aortitis associated with hepatitis C virus-related cryoglobulinemia. (20728096)
2010
23
Enhanced hepatitis C virus genome replication and lipid accumulation mediated by inhibition of AMP-activated protein kinase. (20534540)
2010
24
Evaluation of the role of three candidate human kinases in the conversion of the hepatitis C virus inhibitor 2'-C-methyl-cytidine to its 5'-monophosphate metabolite. (19883694)
2010
25
The role of P-glycoprotein in the pharmacokinetics and tissue distribution of a hepatitis C virus protease inhibitor. (19995330)
2009
26
Hepatitis C virus receptor expression in normal and diseased liver tissue. (18085708)
2008
27
Hepatitis C virus infection in mouse hepatoma cells co-expressing human CD81 and Sip-L. (18474223)
2008
28
A novel, helminth-derived immunostimulant enhances human recall responses to hepatitis C virus and tetanus toxoid and is dependent on CD56+ cells for its action. (18341617)
2008
29
Hepatitis C virus NS5A protein interacts with and negatively regulates the non-receptor protein tyrosine kinase Syk. (18420802)
2008
30
Etiologic treatment of hepatitis C virus-associated mixed cryoglobulinemia. (17936209)
2007
31
Elevated serum levels of interferon- gamma -inducible protein-10 in patients coinfected with hepatitis C virus and HIV. (17763328)
2007
32
Serum-derived hepatitis C virus infectivity in interferon regulatory factor-7-suppressed human primary hepatocytes. (17112629)
2007
33
Analysis of mutations within the 5' untranslated region, interferon sensitivity region, and PePHD region as a function of response to interferon therapy in hepatitis C virus-infected patients in India. (16517843)
2006
34
Interferon-alpha suppresses liver cell proliferation in patients with chronic hepatitis C virus infection. (16108765)
2005
35
Binding of hepatitis C virus envelope protein E2 to CD81 up-regulates matrix metalloproteinase-2 in human hepatic stellate cells. (15611113)
2005
36
Effects of combined antiviral therapy on asymptomatic mixed cryoglobulinemia in naive patients with chronic hepatitis C virus infection: a preliminary study. (16416186)
2005
37
Treatment of chronic hepatitis C virus in allogeneic bone marrow transplant recipients. (16062173)
2005
38
Screening and cloning target genes transactivated by hepatitis C virus F protein using suppression subtractive hybridization technique. (16174453)
2005
39
Human VAP-B is involved in hepatitis C virus replication through interaction with NS5A and NS5B. (16227268)
2005
40
Structural biology of human CD81, a receptor for hepatitis C virus]. (15449903)
2004
41
Iron regulates hepatitis C virus translation via stimulation of expression of translation initiation factor 3. (15272411)
2004
42
Interleukin-1beta gene polymorphisms associated with hepatocellular carcinoma in hepatitis C virus infection. (12500190)
2003
43
Human leukocyte antigen class I and II alleles and response to interferon-alpha treatment, in Taiwanese patients with chronic hepatitis C virus infection. (12825172)
2003
44
Interferon responsiveness in patients infected with hepatitis C virus 1b differs depending on viral subtype. (11454804)
2001
45
The amino acid sequence of the PKR-eIF2alpha phosphorylation homology domain of hepatitis C virus envelope 2 protein and response to interferon-alpha. (11023475)
2000
46
Prevalence of hepatitis C virus associated cryoglobulinemia at a veterans hospital. (9375872)
1997
47
An atypical verrucous carcinoma of the tongue arising in a patient with oral lichen planus associated with hepatitis C virus infection. (9307733)
1997
48
Diversity of quasispecies in various disease stages of chronic hepatitis C virus infection and its significance in interferon treatment. (7541387)
1995
49
Hepatitis C virus associated membranous glomerulonephritis. (8556829)
1995
50
Hepatitis C virus antibody titration in patients with chronic hepatitis C, before and after interferon treatment. (1279945)
1992

Variations for Hepatitis C Virus

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Clinvar genetic disease variations for Hepatitis C Virus:

6
id Gene Variation Type Significance SNP ID Assembly Location
1PTPRCPTPRC, 77C-Gsingle nucleotide variantrisk factor

Expression for genes affiliated with Hepatitis C Virus

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Search GEO for disease gene expression data for Hepatitis C Virus.

Pathways for genes affiliated with Hepatitis C Virus

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Pathways related to Hepatitis C Virus according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
BCR signaling pathway36
TCR Signaling Pathway36
10.3IFNG, CCR5, PTPRC

Compounds for genes affiliated with Hepatitis C Virus

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Compounds related to Hepatitis C Virus according to GeneCards Suite gene sharing:

idCompoundScoreTop Affiliating Genes
1ribavirin43 49 1212.4IFNG, IFNL3, CCR5
2indinavir43 49 1212.4IFNG, CCR5
3lutein4310.4PTPRC, SCARB1
4simvastatin43 49 59 28 24 1215.2SCARB1, CCR5, IFNG
5adalimumab43 49 1212.1IFNG, PTPRC

GO Terms for genes affiliated with Hepatitis C Virus

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Cellular components related to Hepatitis C Virus according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:000989710.3IFNG, CCR5, PTPRC

Biological processes related to Hepatitis C Virus according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1viral processGO:001603210.2ACY3, CCR5, SCARB1, DDX3X
2defense response to virusGO:005160710.2IFNG, IFNL3, PTPRC
3cell surface receptor signaling pathwayGO:000716610.0PTPRC, CCR5, IFNG

Molecular functions related to Hepatitis C Virus according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00055159.8NOLC1, HDDC2, SPG20, SCARB1, PTPRC, MEMO1

Products for genes affiliated with Hepatitis C Virus

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Hepatitis C Virus

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet