MCID: HPT007
MIFTS: 50

Hepatitis E malady

Summaries for Hepatitis E

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A viral infectious disease that results in inflammation located in liver, has material basis in hepatitis e virus, which is transmitted by ingestion of contaminated food. the infection has symptom fever, has symptom fatigue, has symptom loss of appetite, has symptom nausea, has symptom vomiting, has symptom abdominal pain, has symptom clay-colored bowel movements, has symptom dark urine, has symptom joint pain, and has symptom jaundice.

MalaCards: Hepatitis E is related to hepatitis and hepatitis a, and has symptoms including fatigue, loss of appetite and nausea. An important gene associated with Hepatitis E is CD40LG (CD40 ligand), and among its related pathways are Common Pathway and Activation of Genes by ATF4. The compounds ursodeoxycholic acid and hirudin have been mentioned in the context of this disorder. Affiliated tissues include liver, liver and kidney, and related mouse phenotype endocrine/exocrine gland.

Wikipedia:63 Hepatitis E is a viral hepatitis (liver inflammation) caused by infection with a virus called hepatitis... more...

Aliases & Classifications for Hepatitis E

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH
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Aliases & Descriptions:

hepatitis e 8 42 10 44 60


External Ids:

Disease Ontology8 DOID:4411
MeSH34 D016751

Related Diseases for Hepatitis E

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Hepatitis C family:

hepatitis e Hepatitis B
Autoimmune Hepatitis Hepatitis D
Hepatitis a Hepatitis
Viral Hepatitis Hepatitis C Virus

Diseases related to Hepatitis E via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 70)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis31.9F2, HELLS, CD40LG, CD99, HBE1, GPT
2hepatitis a31.5F2, HBE1
3viral hepatitis30.8F2, GPT
4acute liver failure30.6F2, GPT
5hepatitis b30.4F2, GPT, HBE1
6autoimmune hepatitis30.4F2, GPT, CD40LG
7hepatitis c30.2F2, GPT, CD40LG, HELLS
8leukemia30.2HELLS, SAFB, DDIT3, HCK, CD40LG, CD99
9hepatitis d29.9HBE1
10cryoglobulinemia29.9CD40LG
11malaria29.9AMBP
12guillain-barre syndrome10.2
13autoimmune hemolytic anemia10.2
14drug-induced hepatitis10.2
15hemolytic anemia10.2
16liver disease10.2
17acute pancreatitis10.1
18hepatic encephalopathy10.1
19pancreatitis10.1
20cryoglobulinemic vasculitis10.0CD40LG
21acquired immunodeficiency syndrome10.0HCK
22cholecystitis10.0GPT
23thromboembolism10.0F2
24deficiency anemia10.0HBE1, F2
25alpha thalassemia10.0HBE1
26arthritis10.0HPX, AMBP
27myocardial infarction10.0FGB
28pyelonephritis10.0AMBP
29cholelithiasis10.0GPT
30hypercholesterolemia10.0GPT
31blood protein disease10.0F2, CD40LG
32diabetes mellitus10.0AMBP, CD40LG, GPT
33rheumatoid arthritis10.0HPX, CD40LG, AMBP
34pulmonary embolism10.0FGB, F2
35disseminated intravascular coagulation10.0F2
36nephrotic syndrome10.0AMBP
37primary biliary cirrhosis10.0F2, GPT, CD40LG
38ischemia10.0ATF4
39dysfibrinogenemia10.0F2
40choroid plexus carcinoma10.0SPAG11A, SPAG11B
41infertility10.0AMBP
42sarcoma10.0HELLS, DDIT3, CD99
43hepatocellular carcinoma10.0DDIT3, HBE1, GPT, F2, TSG101
44biliary atresia10.0GPT
45myeloma10.0DDIT3, CD40LG
46dengue hemorrhagic fever10.0CD40LG
47ipex syndrome10.0HELLS, HCK, CD40LG, GPT, TSG101
48atherosclerosis10.0CD40LG, HPX
49breast cancer10.0TSG101, ATF4, DDIT3, SAFB, HELLS, AMBP
50afibrinogenemia10.0F2, FGB

Graphical network of the top 20 diseases related to Hepatitis E:



Diseases related to hepatitis e

Clinical Features for Hepatitis E

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Sources:
8Disease Ontology
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Symptoms:

8 (show all 10)
  • fatigue
  • loss of appetite
  • nausea
  • vomiting
  • abdominal pain
  • clay-colored bowel movements
  • dark urine
  • joint pain
  • jaundice
  • fever

Drugs & Therapeutics for Hepatitis E

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Hepatitis E

Drug clinical trials:

Search ClinicalTrials for Hepatitis E

Search NIH Clinical Center for Hepatitis E

Search CenterWatch for Hepatitis E

Genetic Tests for Hepatitis E

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Anatomical Context for Hepatitis E

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Hepatitis E:

32
Liver, Kidney, T cells, Testes, Thyroid, Heart, Brain, Colon, Endothelial, Lung, Monocytes, Bone, Bone marrow

FMA organs/tissues related to Hepatitis E:

14
Liver

Animal Models for Hepatitis E or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Hepatitis E:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537910.0TSG101, ASZ1, CD40LG, DDIT3, SAFB, AMBP

Publications for Hepatitis E

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Sources:
50PubMed
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Articles related to Hepatitis E:

(show top 50)    (show all 775)
idTitleAuthorsYear
1
Ribavirin Inhibits In Vitro Hepatitis E Virus Replication through Depletion of Cellular GTP Pools and Is Moderately Synergistic with Alpha Interferon. (24145541)
2014
2
Hepatitis E: An emerging disease. (24434240)
2014
3
No evidence for hepatitis E virus genotype 3 susceptibility in rats. (23876517)
2013
4
Mutagenesis of hepatitis E virus helicase motifs: Effects on enzyme activity. (24333153)
2013
5
Transmission of hepatitis E virus from rabbits to cynomolgus macaques. (23628346)
2013
6
Hepatitis E Virus Infection in Two Different Community Settings with Identification of Swine HEV Genotype 3 in Indonesia. (23865729)
2013
7
Novel Hepatitis E Like Virus Found in Swedish moose. (24296469)
2013
8
Performance of anti-HEV assays for diagnosing acute hepatitis E in immunocompromised patients. (24183927)
2013
9
Characterization of self-assembled virus-like particles of ferret hepatitis E virus generated by recombinant baculoviruses. (24018315)
2013
10
Evaluation of antigenicity and cell mediated immunity of hepatitis E virus patients: using non radioactive MTT assay. (23508432)
2013
11
Hepatitis E: the forgotten virus. (24109137)
2013
12
Asian musk shrew as a reservoir of rat hepatitis E virus, China. (23876489)
2013
13
Seroprevalence of hepatitis e among pregnant women in urmia, iran. (24348644)
2013
14
Seasonal pattern of hepatitis E virus prevalence in swine in two different geographical areas of China. (23388392)
2013
15
Analysis of antiviral response in human epithelial cells infected with hepatitis E virus. (23671700)
2013
16
The hepatitis E virus capsid C-terminal region is essential for the viral life cycle: implication for viral genome encapsidation and particle stabilization. (23468481)
2013
17
High prevalence of rat hepatitis E virus in wild rats in China. (23623690)
2013
18
Chronic hepatitis E infection: risks and controls. (23689166)
2013
19
Update of cases of acute hepatitis E confirmed by the National Centre of Microbiology (Spain, 2004-2011). (22877513)
2013
20
The ORF2 glycoprotein of hepatitis E virus inhibits cellular NF-I_B activity by blocking ubiquitination mediated proteasomal degradation of II_BI+ in human hepatoma cells. (22590978)
2012
21
Serological and molecular study of hepatitis E virus among illegal blood donors. (22408360)
2012
22
Adaptation of genotype 3 hepatitis E virus in Eastern China and inverse correlation with genotype 4 hepatitis E virus. (22156659)
2012
23
Thermal inactivation of infectious hepatitis E virus in experimentally contaminated food. (22610436)
2012
24
The hepatitis E virus polyproline region is involved in viral adaptation. (22545153)
2012
25
A Review of the neurological manifestations of hepatitis E infection. (22947521)
2012
26
Clinical features and risk factors of acute hepatitis E with severe jaundice. (23326133)
2012
27
Hepatitis E virus coinfection in patients with HIV infection. (21819531)
2012
28
First human case of co-infection with two different subtypes of hepatitis E virus. (22398950)
2012
29
The open reading frame 2 initiation site of genotype 4 hepatitis E virus (HEV). (22019389)
2012
30
Ribavirin therapy for hepatitis E virus-induced acute on chronic liver failure: a preliminary report. (22910532)
2012
31
Immature and mature human astrovirus: structure, conformational changes, and similarities to hepatitis E virus. (22743104)
2012
32
Circulation of almost genetically identical hepatitis E virus of genotype 4 in France. (22835777)
2012
33
Hepatitis E virus in rats, Los Angeles, California, USA. (22172320)
2011
34
Transfusion-transmitted hepatitis E: is screening warranted? (22120793)
2011
35
Toward the development of a hepatitis E vaccine. (21620908)
2011
36
Rescue monotherapy in lamivudine-resistant hepatitis B e antigen-positive chronic hepatitis B: adefovir versus entecavir. (19704174)
2009
37
Influence of genotype on hepatitis B surface antigen kinetics in hepatitis B e antigen-negative patients treated with pegylated interferon-alpha2a. (20032548)
2009
38
Nutritional status of patients with biliary atresia and autoimmune hepatitis related to serum levels of vitamins A, D and E. (19466312)
2009
39
Acute pancreatitis--complicating hepatitis E virus infection in a 7-year-old boy with glucose 6 phosphate dehydrogenase deficiency. (19129425)
2009
40
Spontaneous Resolution of Brain Edema in Fulminant Hepatic Failure due to Hepatitis E. (21897793)
2008
41
Polymorphism in intron 1 of the interferon-gamma gene influences both serum immunoglobulin E levels and the risk for chronic hepatitis B virus infection in Polynesians. (17211638)
2007
42
An analysis of the clinical characteristics of patients with chronic hepatitis B superinfected with acute hepatitis E]. (18322591)
2007
43
Hepatitis E infection with Bell's palsy. (16909746)
2006
44
IgM to recombinant antigen E2 of HEV envelope protein is a sensitive and specific serological marker in diagnosis of acute hepatitis E]. (16092982)
2005
45
Molecular and serological characterization of sporadic acute hepatitis E in a Japanese patient infected with a genotype III hepatitis E virus in 1993. (12560575)
2003
46
TT virus infection in acute non-A to E hepatitis in northern Thailand. (12041559)
2001
47
Long-term outcome of hepatitis B e antigen-positive patients with compensated cirrhosis treated with interferon alfa. European Concerted Action on Viral Hepatitis (EUROHEP). (9362381)
1997
48
Long-term evolution of chronic hepatitis B in children with antibody to hepatitis B e antigen. (2319401)
1990
49
Chronic hepatitis B. Impact of hepatitis D virus superinfection and the hepatitis B e-system on histological outcome, and correlation of the hepatitis B e-system to HBV-DNA in serum. (3468608)
1986
50
Identification and characterization of mixed disulphide complexes of E apoprotein in high density lipoprotein of subjects with acute alcoholic hepatitis. (227391)
1979

Genetic Variations for Hepatitis E

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Expression for genes affiliated with Hepatitis E

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hepatitis E

Search GEO for disease gene expression data for Hepatitis E.

Pathways for genes affiliated with Hepatitis E

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53Reactome, 51QIAGEN
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Pathways related to Hepatitis E according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4F2, FGB
2
Hide members
10.3ATF4, DDIT3

Compounds for genes affiliated with Hepatitis E

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Hepatitis E according to GeneCards/GeneDecks:

(show all 25)
idCompoundScoreTop Affiliating Genes
1ursodeoxycholic acid44 11 2412.6F2, GPT, CD40LG
2hirudin4410.6CD40LG, FGB, F2
3monoethylglycinexylidide4410.6GPT, F2
4batroxobin4410.6FGB, F2
5ribavirin44 49 1112.6HELLS, CD40LG, GPT
6hepaplastin4410.6GPT, F2
7ximelagatran44 1111.6F2, GPT
8hyaluronic acid44 2411.6AMBP, CD40LG, HPX, GPT, F2
9calcium oxalate4410.5AMBP, F2
10vitamin a44 11 2412.5GPT, HPX, CD40LG, AMBP
11nacl4410.5HELLS, HPX, FGB, SPAG11B
12n acetylcysteine4410.5DDIT3, ATF4, CD40LG, GPT, F2
13aminopyrine4410.5GPT, F2
14fibrinogen4410.4F2, GPT, FGB, HPX, CD40LG, HCK
15serine4410.4AMBP, HELLS, SAFB, ATF4, HPX
16cisplatin44 49 59 1113.4CD40LG, ATF4, DDIT3, HELLS, AMBP
17alanine4410.4C16orf80, AMBP, HELLS, SAFB, CD40LG, GPT
18ppack4410.4F2, CD40LG
19leucine4410.4AMBP, HELLS, SAFB, DDIT3, ATF4, TSG101
20retinoic acid44 2411.3C16orf80, AMBP, HELLS, SAFB, DDIT3, HCK
21vitamin d4410.3GPT, HPX, SAFB, C16orf80
22asparagine4410.3GPT, ATF4, DDIT3
23trichloroethylene4410.3AMBP, GPT
24homocysteine44 2411.3F2, ATF4, DDIT3
25amantadine44 1111.1GPT, HELLS

GO Terms for genes affiliated with Hepatitis E

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16Gene Ontology
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Biological processes related to Hepatitis E according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressGO:07005910.3ATF4, DDIT3
2viral processGO:01603210.1TSG101, HCK, VPS4A, RPS17
3modulation by virus of host morphology or physiologyGO:0190489.9AMBP, HCK, HPX, TSG101

Products for genes affiliated with Hepatitis E

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hepatitis E

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet