MCID: HPT007
MIFTS: 53

Hepatitis E malady

Rare diseases, Infectious diseases, Gastrointestinal diseases, Liver diseases, Immune diseases categories
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Summaries for Hepatitis E

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Disease Ontology:8 A viral infectious disease that results in inflammation located in liver, has material basis in hepatitis e virus, which is transmitted by ingestion of contaminated food. the infection has symptom fever, has symptom fatigue, has symptom loss of appetite, has symptom nausea, has symptom vomiting, has symptom abdominal pain, has symptom clay-colored bowel movements, has symptom dark urine, has symptom joint pain, and has symptom jaundice.

MalaCards based summary: Hepatitis E is related to hepatitis and viral hepatitis, and has symptoms including An important gene associated with Hepatitis E is CD40LG (CD40 ligand), and among its related pathways are Apoptosis and survival Anti apoptotic TNFs NF kB Bcl 2 pathway and Inflammatory Response Pathway. The compounds ppack and monoethylglycinexylidide have been mentioned in the context of this disorder. Affiliated tissues include liver, liver and kidney.

Wikipedia:65 Hepatitis E is a viral hepatitis (liver inflammation) caused by infection with a virus called hepatitis... more...

Aliases & Classifications for Hepatitis E

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Hepatitis E, Aliases & Descriptions:

Name: Hepatitis E 8 42 10 44 62


Classifications:



External Ids:

Disease Ontology8 DOID:4411
MeSH34 D016751

Related Diseases for Hepatitis E

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Diseases in the Hepatitis C family:

Autoimmune Hepatitis Hepatitis
Hepatitis B Hepatitis D
Hepatitis a hepatitis e
Viral Hepatitis Hepatitis C Virus
Susceptibility to Hepatitis Due to Voriconazole Treatment Susceptibility to Hepatitis Due to Flucloxacilline Treatment

Diseases related to Hepatitis E via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 82)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis32.4GPT, F2
2viral hepatitis31.2F2, GPT
3hepatitis a31.0F2, HBE1
4acute liver failure30.9GPT, F2
5hepatitis b30.8GPT, F2
6hepatitis d30.5HBE1
7alcoholic hepatitis30.4GPT, F2
8cholestasis30.3GPT, F2
9hepatitis c30.2CD40LG, GPT, F2
10hemorrhagic fever10.5CD40LG
11cholecystitis10.5GPT
12choledocholithiasis10.5GPT
13wegener's granulomatosis10.4CD86
14scrub typhus10.3CD40LG, GPT
15splenomegaly10.3
16blood protein disease10.3CD40LG, F2
17bilirubin metabolic disorder10.3F2, GPT
18pregnancy loss10.3CD40LG, F2
19portal hypertension10.3GPT, F2
20hepatic encephalopathy10.3GPT, F2
21antiphospholipid syndrome10.3F2, CD40LG
22galactosemia10.3F2
23acute kidney failure10.3GPT, AMBP
24alcoholic liver cirrhosis10.3F2, GPT
25guillain-barre syndrome10.3
26common variable immunodeficiency10.2CD86, CD40LG
27schistosomiasis10.2CD40LG, CD86
28leukopenia10.2F2, GPT
29lupus erythematosus10.2CD40LG, F2
30hemolytic anemia10.2
31leukemia10.2
32liver disease10.2
33autoimmune hemolytic anemia10.2
34sjogren's syndrome10.2CD40LG, CD86
35brain disease10.2F2, GPT
36vasculitis10.2CD40LG, F2
37autoimmune hepatitis10.1GPT, F2, CD40LG
38primary biliary cirrhosis10.1CD40LG, GPT, F2
39thrombocytopenia10.1F2, GPT, CD40LG
40tetanus10.1CD86, CD40LG
41congenital heart disease10.1F2, CD40LG
42hematopoietic stem cell transplantation10.1
43acute pancreatitis10.1
44pancreatitis10.1
45diabetes mellitus10.1CD40LG, GPT, AMBP
46acute graft versus host disease10.1TNFRSF4, AMBP
47connective tissue disease10.1F2, CD86, CD40LG
48nodular goiter10.1CD86, TNFRSF4
49liver cirrhosis10.0F2, HBE1, GPT
50myasthenia gravis10.0CD86, TNFRSF4

Graphical network of the top 20 diseases related to Hepatitis E:



Diseases related to hepatitis e

Symptoms for Hepatitis E

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Drugs & Therapeutics for Hepatitis E

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Drug clinical trials:

Search ClinicalTrials for Hepatitis E

Search NIH Clinical Center for Hepatitis E

Genetic Tests for Hepatitis E

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Anatomical Context for Hepatitis E

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MalaCards organs/tissues related to Hepatitis E:

32
Liver, Kidney, Testes, T cells, Heart, Bone marrow, Bone, Brain, Lung, Thyroid, B cells

FMA organs/tissues related to Hepatitis E:

14
Liver

Animal Models for Hepatitis E or affiliated genes

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Publications for Hepatitis E

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Articles related to Hepatitis E:

(show top 50)    (show all 589)
idTitleAuthorsYear
1
Fetal and Neonatal Health Consequences of Vertically Transmitted Hepatitis E Virus Infection. (24420778)
2014
2
Hepatitis e virus infections in blood donors, france. (25340881)
2014
3
Hepatitis E: an old infection with new implications. (25369613)
2014
4
Neuralgic amyotrophy and hepatitis E virus infection. (24401685)
2014
5
Chronic hepatitis E: a review of the literature. (24383921)
2014
6
Zoonotic transmission of hepatitis E virus in industrialized countries. (24177295)
2013
7
Marked genomic heterogeneity of rat hepatitis E virus strains in Indonesia demonstrated on a full-length genome analysis. (24231359)
2013
8
Hepatitis E. (23982238)
2013
9
Molecular detection of hepatitis E virus in German domestic pigs. (23367665)
2013
10
No evidence for hepatitis E virus genotype 3 susceptibility in rats. (23876517)
2013
11
Mutagenesis of hepatitis E virus helicase motifs: Effects on enzyme activity. (24333153)
2013
12
Zoonotic and foodborne transmission of hepatitis E virus. (23564388)
2013
13
Epidemiologic concerns and advances in knowledge on hepatitis e. (23961267)
2013
14
Anti hepatitis E virus seropositivity in a group of male blood donors in Makkah, Saudi Arabia. (23894892)
2013
15
Epidemiology of mammalian hepatitis E virus infection. (23343760)
2013
16
Rash and arthralgia caused by hepatitis E. (24290589)
2013
17
A longitudinal study revealing hepatitis E virus infection and transmission at a swine test station. (24119762)
2013
18
Zoonotic hepatitis E virus strains in German blood donors. (22913247)
2013
19
Immunopathogenesis of hepatitis E virus infection. (23564391)
2013
20
Chronic Hepatitis E as a cause for cryptogenic cirrhosis in HIV. (22166370)
2013
21
Test performance characteristics of Anti-HEV IgG assays strongly influence hepatitis E seroprevalence estimates. (23148290)
2013
22
Transmission of hepatitis E virus from rabbits to cynomolgus macaques. (23628346)
2013
23
Avian hepatitis E virus identified in Russian chicken flocks exhibits high genetic divergence based on the ORF2 capsid gene. (22967203)
2012
24
Rat hepatitis E virus: geographical clustering within Germany and serological detection in wild Norway rats (Rattus norvegicus). (22554648)
2012
25
Prolonged jaundice attributed to super infection of hepatitis E virus in a case of resolving leptospirosis. (22361773)
2012
26
The ORF2 glycoprotein of hepatitis E virus inhibits cellular NF-I_B activity by blocking ubiquitination mediated proteasomal degradation of II_BI+ in human hepatoma cells. (22590978)
2012
27
Hepatitis E virus (HEV)-specific T-cell responses are associated with control of HEV infection. (22006345)
2012
28
A retrospective study on imported hepatitis E in Japan. (22405678)
2012
29
Fatal hepatitis E viral infection in pregnant women in Ghana: a case series. (22937872)
2012
30
Chronic hepatitis E infection in children with liver transplantation. (22115826)
2012
31
Hepatitis E virus as a causative agent of unexplained liver enzyme elevations in HIV-infected patients. (22622079)
2012
32
Complete genome sequence of the genotype 4 hepatitis E virus strain prevalent in swine in Jiangsu Province, China, reveals a close relationship with that from the human population in this area. (22787267)
2012
33
A naturally occurring human/hepatitis E recombinant virus predominates in serum but not in faeces of a chronic hepatitis E patient and has a growth advantage in cell culture. (22113007)
2012
34
Hepatitis E infection is an under recognized cause of acute decompensation in patients with chronic liver disease. (22592074)
2012
35
Chronic hepatitis E virus infection in a patient with leukemia and elevated transaminases: a case report. (23031738)
2012
36
A549 and PLC/PRF/5 cells can support the efficient propagation of swine and wild boar hepatitis E virus (HEV) strains: demonstration of HEV infectivity of porcine liver sold as food. (22048607)
2012
37
Hepatitis: hepatitis E and decompensated chronic liver disease. (22733353)
2012
38
Identifications of polyphyletic variants in acute hepatitis suggest an underdiagnosed circulation of hepatitis E virus in Argentina. (21795113)
2011
39
Hepatitis E virus ORF2 protein activates the pro-apoptotic gene CHOP and anti-apoptotic heat shock proteins. (21966512)
2011
40
Hepatitis E virus in rats, Los Angeles, California, USA. (22172320)
2011
41
Close similarity between sequences of hepatitis E virus recovered from humans and swine, France, 2008-2009. (22099089)
2011
42
Hepatitis E virus-related acute liver failure associated with pure red cell aplasia. (21947733)
2011
43
Hepatitis E virus infection in macaca mulatta. (22224088)
2011
44
Seroepidemiology and molecular characterization of hepatitis E Virus in Macaca mulatta from a village in Yunnan, China, where infection with this virus is endemic. (22235219)
2011
45
The ORF3 protein of hepatitis E virus delays degradation of activated growth factor receptors by interacting with CIN85 and blocking formation of the Cbl-CIN85 complex. (20130058)
2010
46
Prevalence of hepatitis E virus infection in liver transplant recipients. (19790147)
2009
47
Fulminant hepatic failure in a patient with inactive HBsAg carrier state, acute hepatitis E and thyrotoxicosis. (14585402)
2003
48
Role of immune serum globulins in pregnant women during an epidemic of hepatitis E. (9658374)
1998
49
Acute sporadic hepatitis E virus infection in southern China. (8550986)
1995
50
Persistent and transient antibody responses to hepatitis E virus detected by western immunoblot using open reading frame 2 and 3 and glutathione S-transferase fusion proteins. (7529246)
1994

Variations for Hepatitis E

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Expression for genes affiliated with Hepatitis E

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Expression patterns in normal tissues for genes affiliated with Hepatitis E

Search GEO for disease gene expression data for Hepatitis E.

Pathways for genes affiliated with Hepatitis E

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Pathways related to Hepatitis E according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Apoptosis and survival Anti apoptotic TNFs NF kB IAP pathway60
9.5CD40LG, TNFRSF4
29.3CD40LG, CD86

Compounds for genes affiliated with Hepatitis E

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Compounds related to Hepatitis E according to GeneCards/GeneDecks:

(show all 43)
idCompoundScoreTop Affiliating Genes
1ppack4410.1CD40LG, F2
2monoethylglycinexylidide4410.1F2, GPT
3hepaplastin4410.1F2, GPT
4tirofiban44 1111.1CD40LG, F2
5ximelagatran44 1111.1GPT, F2
6aminopyrine4410.1GPT, F2
7abciximab44 1111.1CD40LG, F2
8valproate4410.1CD40LG, GPT
9clopidogrel44 50 24 1113.1CD40LG, F2
10clarithromycin44 1111.1F2, GPT
11mycophenolate mofetil44 50 1112.1GPT, CD40LG
12cardiolipin44 1111.1CD40LG, F2
13hirudin4410.1F2, CD40LG
14fenofibrate44 50 1112.0CD40LG, GPT
15lamivudine44 50 1112.0F2, GPT
16ivig4410.0CD40LG, GPT
17ribavirin44 50 1112.0GPT, CD40LG
18silymarin4410.0GPT, F2
19vitamin b124410.0GPT, CD40LG
20trichloroethylene4410.0GPT, AMBP
21neopterin4410.0CD40LG, GPT
22warfarin44 50 24 1112.9GPT, F2
23calcium oxalate449.9F2, AMBP
24acetaminophen44 2 50 24 1113.8F2, GPT
25pge1449.8GPT, F2
26kininogen449.8AMBP, F2
27ursodeoxycholic acid44 24 1111.8CD40LG, GPT, F2
28n acetylcysteine449.7CD40LG, GPT, F2
29il-12449.7CD86, CD40LG
30polyethylene glycol449.6CD40LG, F2
31vitamin a44 24 1111.6CD40LG, AMBP, GPT
32aprotinin44 1110.6AMBP, F2
33uric acid44 2410.6GPT, AMBP
34allergens449.5CD40LG, CD86
35pravastatin44 50 28 24 1113.5CD40LG, GPT
36hyaluronic acid44 2410.3F2, GPT, AMBP, CD40LG
37fibrinogen449.3F2, GPT, AMBP, CD40LG
38lactate449.2CD40LG, AMBP, GPT, F2
39creatinine449.2F2, GPT, AMBP, CD40LG
40aspartate449.2CD40LG, AMBP, GPT, F2
41alanine449.2F2, GPT, AMBP, CD40LG
42sodium dodecylsulfate449.1CD86, AMBP
43cyclosporin a44 28 619.8CD40LG, CD86, AMBP, TNFRSF4, GPT, F2

GO Terms for genes affiliated with Hepatitis E

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Cellular components related to Hepatitis E according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:0725628.7AMBP, HBE1, F2
2external side of plasma membraneGO:0098978.7CD40LG, CD86, TNFRSF4

Biological processes related to Hepatitis E according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1viral processGO:0160328.7CD86, RPS17, AMBP

Products for genes affiliated with Hepatitis E

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  • Antibodies
  • Proteins
  • Lysates

Sources for Hepatitis E

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet