MCID: HPT007
MIFTS: 45

Hepatitis E malady

Genetic diseases, Rare diseases, Gastrointestinal diseases, Liver diseases, Infectious diseases categories

Summaries for Hepatitis E

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Disease Ontology:9 A viral infectious disease that results in inflammation located in liver, has material basis in hepatitis e virus, which is transmitted by ingestion of contaminated food. the infection has symptom fever, has symptom fatigue, has symptom loss of appetite, has symptom nausea, has symptom vomiting, has symptom abdominal pain, has symptom clay-colored bowel movements, has symptom dark urine, has symptom joint pain, and has symptom jaundice.

MalaCards based summary: Hepatitis E is related to hepatitis and viral hepatitis, and has symptoms including fever, fatigue and loss of appetite. An important gene associated with Hepatitis E is CD40LG (CD40 ligand), and among its related pathways are Apoptosis and survival Anti apoptotic TNFs NF kB Bcl 2 pathway and Inflammatory Response Pathway. The compounds ppack and monoethylglycinexylidide have been mentioned in the context of this disorder. Affiliated tissues include liver, liver and kidney.

Wikipedia:63 Hepatitis E is a viral hepatitis (liver inflammation) caused by infection with a virus called hepatitis... more...

Aliases & Classifications for Hepatitis E

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Hepatitis E, Aliases & Descriptions:

Name: Hepatitis E 9 41 11 43 60


Classifications:



External Ids:

Disease Ontology9 DOID:4411
MeSH33 D016751

Related Diseases for Hepatitis E

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Diseases in the Hepatitis family:

Hepatitis C Virus Autoimmune Hepatitis
Hepatitis B Hepatitis C
Hepatitis D Hepatitis a
hepatitis e Viral Hepatitis

Diseases related to Hepatitis E via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 91)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis32.4GPT, F2
2viral hepatitis31.2F2, GPT
3hepatitis a31.0F2, HBE1
4acute liver failure30.9GPT, F2
5hepatitis b30.8GPT, F2
6liver disease30.7F2
7hepatitis d30.5HBE1
8cholestasis30.3GPT, F2
9hepatitis c30.2CD40LG, GPT, F2
10rheumatoid arthritis29.5AMBP, TNFRSF4, CD86, CD40LG
11hemorrhagic fever10.5CD40LG
12cholecystitis10.5GPT
13choledocholithiasis10.5GPT
14wegener granulomatosis10.4CD86
15scrub typhus10.3CD40LG, GPT
16splenomegaly10.3
17blood protein disease10.3CD40LG, F2
18bilirubin metabolic disorder10.3F2, GPT
19portal hypertension10.3GPT, F2
20hepatic encephalopathy10.3GPT, F2
21pregnancy loss, recurrent 110.3F2, CD40LG
22leukemia10.3
23guillain-barre syndrome10.3
24alcoholic hepatitis10.3GPT, F2
25antiphospholipid syndrome10.3F2, CD40LG
26acute kidney failure10.3GPT, AMBP
27alcoholic liver cirrhosis10.3F2, GPT
28common variable immunodeficiency10.2CD86, CD40LG
29schistosomiasis10.2CD40LG, CD86
30leukopenia10.2F2, GPT
31galactosemia10.2F2, GPT
32hemolytic anemia10.2
33autoimmune hemolytic anemia10.2
34lupus erythematosus10.2CD40LG, F2
35sjogren's syndrome10.2CD40LG, CD86
36brain disease10.2F2, GPT
37vasculitis10.2CD40LG, F2
38autoimmune hepatitis10.1GPT, F2, CD40LG
39primary biliary cirrhosis10.1CD40LG, GPT, F2
40thrombocytopenia10.1F2, GPT, CD40LG
41tetanus10.1CD86, CD40LG
42hematopoietic stem cell transplantation10.1
43acute pancreatitis10.1
44pancreatitis10.1
45thyroiditis10.1
46congenital heart disease10.1F2, CD40LG
47diabetes mellitus, insulin-dependent10.1CD40LG, GPT, AMBP
48acute graft versus host disease10.1TNFRSF4, AMBP
49connective tissue disease10.1F2, CD86, CD40LG
50nodular goiter10.0CD86, TNFRSF4

Graphical network of the top 20 diseases related to Hepatitis E:



Diseases related to hepatitis e

Symptoms for Hepatitis E

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Symptoms:

 9 (show all 10)
  • fever
  • fatigue
  • loss of appetite
  • nausea
  • vomiting
  • abdominal pain
  • clay-colored bowel movements
  • dark urine
  • joint pain
  • jaundice

Drugs & Therapeutics for Hepatitis E

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Drug clinical trials:

Search ClinicalTrials for Hepatitis E

Search NIH Clinical Center for Hepatitis E

Genetic Tests for Hepatitis E

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Anatomical Context for Hepatitis E

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MalaCards organs/tissues related to Hepatitis E:

31
Liver, Kidney, Testes, T cells, Heart, Thyroid, Bone marrow, Bone, Brain, Lung, B cells

FMA organs/tissues related to Hepatitis E:

14
Liver

Animal Models for Hepatitis E or affiliated genes

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Publications for Hepatitis E

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Articles related to Hepatitis E:

(show top 50)    (show all 612)
idTitleAuthorsYear
1
Outcome of hepatitis e virus infection in patients with inflammatory arthritides treated with immunosuppressants: a French retrospective multicenter study. (25860212)
2015
2
Successful treatment of hepatitis E virus-associated cryoglobulinemic membranoproliferative glomerulonephritis with ribavirin. (25708383)
2015
3
Long-term efficacy of a hepatitis E vaccine. (25853767)
2015
4
Fetal and Neonatal Health Consequences of Vertically Transmitted Hepatitis E Virus Infection. (24420778)
2014
5
Hepatitis e virus infections in blood donors, france. (25340881)
2014
6
Hepatitis E: an old infection with new implications. (25369613)
2014
7
Neuralgic amyotrophy and hepatitis E virus infection. (24401685)
2014
8
Zoonotic transmission of hepatitis E virus in industrialized countries. (24177295)
2013
9
Marked genomic heterogeneity of rat hepatitis E virus strains in Indonesia demonstrated on a full-length genome analysis. (24231359)
2013
10
Hepatitis E. (23982238)
2013
11
Molecular detection of hepatitis E virus in German domestic pigs. (23367665)
2013
12
No evidence for hepatitis E virus genotype 3 susceptibility in rats. (23876517)
2013
13
Mutagenesis of hepatitis E virus helicase motifs: Effects on enzyme activity. (24333153)
2013
14
Zoonotic and foodborne transmission of hepatitis E virus. (23564388)
2013
15
Epidemiologic concerns and advances in knowledge on hepatitis e. (23961267)
2013
16
Anti hepatitis E virus seropositivity in a group of male blood donors in Makkah, Saudi Arabia. (23894892)
2013
17
Epidemiology of mammalian hepatitis E virus infection. (23343760)
2013
18
Rash and arthralgia caused by hepatitis E. (24290589)
2013
19
A longitudinal study revealing hepatitis E virus infection and transmission at a swine test station. (24119762)
2013
20
Zoonotic hepatitis E virus strains in German blood donors. (22913247)
2013
21
Immunopathogenesis of hepatitis E virus infection. (23564391)
2013
22
Chronic Hepatitis E as a cause for cryptogenic cirrhosis in HIV. (22166370)
2013
23
Test performance characteristics of Anti-HEV IgG assays strongly influence hepatitis E seroprevalence estimates. (23148290)
2013
24
Transmission of hepatitis E virus from rabbits to cynomolgus macaques. (23628346)
2013
25
Avian hepatitis E virus identified in Russian chicken flocks exhibits high genetic divergence based on the ORF2 capsid gene. (22967203)
2012
26
Rat hepatitis E virus: geographical clustering within Germany and serological detection in wild Norway rats (Rattus norvegicus). (22554648)
2012
27
The ORF2 glycoprotein of hepatitis E virus inhibits cellular NF-I_B activity by blocking ubiquitination mediated proteasomal degradation of II_BI+ in human hepatoma cells. (22590978)
2012
28
Hepatitis E virus (HEV)-specific T-cell responses are associated with control of HEV infection. (22006345)
2012
29
A retrospective study on imported hepatitis E in Japan. (22405678)
2012
30
Fatal hepatitis E viral infection in pregnant women in Ghana: a case series. (22937872)
2012
31
Chronic hepatitis E infection in children with liver transplantation. (22115826)
2012
32
Hepatitis E virus as a causative agent of unexplained liver enzyme elevations in HIV-infected patients. (22622079)
2012
33
Complete genome sequence of the genotype 4 hepatitis E virus strain prevalent in swine in Jiangsu Province, China, reveals a close relationship with that from the human population in this area. (22787267)
2012
34
A naturally occurring human/hepatitis E recombinant virus predominates in serum but not in faeces of a chronic hepatitis E patient and has a growth advantage in cell culture. (22113007)
2012
35
Hepatitis E infection is an under recognized cause of acute decompensation in patients with chronic liver disease. (22592074)
2012
36
Chronic hepatitis E virus infection in a patient with leukemia and elevated transaminases: a case report. (23031738)
2012
37
A549 and PLC/PRF/5 cells can support the efficient propagation of swine and wild boar hepatitis E virus (HEV) strains: demonstration of HEV infectivity of porcine liver sold as food. (22048607)
2012
38
Identifications of polyphyletic variants in acute hepatitis suggest an underdiagnosed circulation of hepatitis E virus in Argentina. (21795113)
2011
39
Hepatitis E virus ORF2 protein activates the pro-apoptotic gene CHOP and anti-apoptotic heat shock proteins. (21966512)
2011
40
Hepatitis E virus in rats, Los Angeles, California, USA. (22172320)
2011
41
Close similarity between sequences of hepatitis E virus recovered from humans and swine, France, 2008-2009. (22099089)
2011
42
Hepatitis E virus-related acute liver failure associated with pure red cell aplasia. (21947733)
2011
43
Hepatitis E virus infection in macaca mulatta. (22224088)
2011
44
Seroepidemiology and molecular characterization of hepatitis E Virus in Macaca mulatta from a village in Yunnan, China, where infection with this virus is endemic. (22235219)
2011
45
The ORF3 protein of hepatitis E virus delays degradation of activated growth factor receptors by interacting with CIN85 and blocking formation of the Cbl-CIN85 complex. (20130058)
2010
46
Prevalence of hepatitis E virus infection in liver transplant recipients. (19790147)
2009
47
Fulminant hepatic failure in a patient with inactive HBsAg carrier state, acute hepatitis E and thyrotoxicosis. (14585402)
2003
48
Role of immune serum globulins in pregnant women during an epidemic of hepatitis E. (9658374)
1998
49
Acute sporadic hepatitis E virus infection in southern China. (8550986)
1995
50
Persistent and transient antibody responses to hepatitis E virus detected by western immunoblot using open reading frame 2 and 3 and glutathione S-transferase fusion proteins. (7529246)
1994

Variations for Hepatitis E

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Expression for genes affiliated with Hepatitis E

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Search GEO for disease gene expression data for Hepatitis E.

Pathways for genes affiliated with Hepatitis E

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Pathways related to Hepatitis E according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Apoptosis and survival Anti apoptotic TNFs NF kB IAP pathway58
9.5CD40LG, TNFRSF4
29.3CD40LG, CD86

Compounds for genes affiliated with Hepatitis E

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Compounds related to Hepatitis E according to GeneCards Suite gene sharing:

(show all 43)
idCompoundScoreTop Affiliating Genes
1ppack4310.1CD40LG, F2
2monoethylglycinexylidide4310.1F2, GPT
3hepaplastin4310.1F2, GPT
4tirofiban43 1211.1CD40LG, F2
5ximelagatran43 1211.1GPT, F2
6aminopyrine4310.1GPT, F2
7abciximab43 1211.1CD40LG, F2
8valproate4310.1CD40LG, GPT
9clopidogrel43 49 24 1213.1CD40LG, F2
10clarithromycin43 1211.1F2, GPT
11mycophenolate mofetil43 49 1212.1GPT, CD40LG
12cardiolipin43 1211.1CD40LG, F2
13hirudin4310.1F2, CD40LG
14fenofibrate43 49 1212.0CD40LG, GPT
15lamivudine43 49 1212.0F2, GPT
16ivig4310.0CD40LG, GPT
17ribavirin43 49 1212.0GPT, CD40LG
18silymarin4310.0GPT, F2
19vitamin b124310.0GPT, CD40LG
20trichloroethylene4310.0GPT, AMBP
21neopterin4310.0CD40LG, GPT
22warfarin43 49 24 1212.9GPT, F2
23calcium oxalate439.9F2, AMBP
24acetaminophen43 2 49 24 1213.8F2, GPT
25pge1439.8GPT, F2
26kininogen439.8AMBP, F2
27ursodeoxycholic acid43 24 1211.8CD40LG, GPT, F2
28n acetylcysteine439.7CD40LG, GPT, F2
29il-12439.7CD86, CD40LG
30polyethylene glycol439.6CD40LG, F2
31vitamin a43 24 1211.6CD40LG, AMBP, GPT
32aprotinin43 1210.6AMBP, F2
33uric acid43 2410.6GPT, AMBP
34allergens439.5CD40LG, CD86
35pravastatin43 49 28 24 1213.5CD40LG, GPT
36hyaluronic acid43 2410.3F2, GPT, AMBP, CD40LG
37fibrinogen439.3F2, GPT, AMBP, CD40LG
38lactate439.2CD40LG, AMBP, GPT, F2
39creatinine439.2F2, GPT, AMBP, CD40LG
40aspartate439.2CD40LG, AMBP, GPT, F2
41alanine439.2F2, GPT, AMBP, CD40LG
42sodium dodecylsulfate439.1CD86, AMBP
43cyclosporin a43 28 599.8CD40LG, CD86, AMBP, TNFRSF4, GPT, F2

GO Terms for genes affiliated with Hepatitis E

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Cellular components related to Hepatitis E according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:00725628.7AMBP, HBE1, F2
2external side of plasma membraneGO:00098978.7CD40LG, CD86, TNFRSF4

Biological processes related to Hepatitis E according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1viral processGO:00160328.7CD86, RPS17, AMBP

Products for genes affiliated with Hepatitis E

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Hepatitis E

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet