MCID: HPT007
MIFTS: 52

Hepatitis E malady

Rare diseases, Infectious diseases, Gastrointestinal diseases, Liver diseases, Immune diseases categories
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Summaries for Hepatitis E

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Sources:
8Disease Ontology, 65Wikipedia, 33MalaCards
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Disease Ontology:8 A viral infectious disease that results in inflammation located in liver, has material basis in hepatitis e virus, which is transmitted by ingestion of contaminated food. the infection has symptom fever, has symptom fatigue, has symptom loss of appetite, has symptom nausea, has symptom vomiting, has symptom abdominal pain, has symptom clay-colored bowel movements, has symptom dark urine, has symptom joint pain, and has symptom jaundice.

MalaCards: Hepatitis E is related to hepatitis and viral hepatitis, and has symptoms including jaundice, fatigue and loss of appetite. An important gene associated with Hepatitis E is CD40LG (CD40 ligand), and among its related pathways are Apoptosis and survival Anti apoptotic TNFs NF kB Bcl 2 pathway and Inflammatory Response Pathway. The compounds ppack and monoethylglycinexylidide have been mentioned in the context of this disorder. Affiliated tissues include liver, liver and kidney.

Wikipedia:65 Hepatitis E is a viral hepatitis (liver inflammation) caused by infection with a virus called hepatitis... more...

Aliases & Classifications for Hepatitis E

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8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 62UMLS, 35MeSH
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Classifications:



Aliases & Descriptions:

hepatitis e 8 43 10 45 62


External Ids:

Disease Ontology8 DOID:4411
MeSH35 D016751

Related Diseases for Hepatitis E

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Hepatitis C family:

Autoimmune Hepatitis Hepatitis B
Hepatitis D Hepatitis a
hepatitis e Hepatitis
Viral Hepatitis Hepatitis C Virus

Diseases related to Hepatitis E via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 80)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis32.1F2, GPT
2viral hepatitis30.8GPT, F2
3hepatitis a30.7F2, HBE1
4acute liver failure30.6GPT, F2
5hepatitis b30.5GPT, F2
6hepatitis d30.1HBE1
7cholestasis30.0GPT, F2
8hepatitis c30.0CD40LG, GPT, F2
9guillain-barre syndrome10.3
10splenomegaly10.3
11autoimmune hemolytic anemia10.2
12hemolytic anemia10.2
13leukemia10.2
14liver disease10.2
15hemorrhagic fever10.1CD40LG
16cholecystitis10.1GPT
17choledocholithiasis10.1GPT
18acute pancreatitis10.1
19pancreatitis10.1
20hematopoietic stem cell transplantation10.1
21wegener's granulomatosis10.1CD86
22scrub typhus10.1GPT, CD40LG
23blood protein disease10.1CD40LG, F2
24alcoholic hepatitis10.1F2, GPT
25hepatic encephalopathy10.1F2, GPT
26pregnancy loss10.1F2, CD40LG
27bilirubin metabolic disorder10.1F2, GPT
28portal hypertension10.1F2, GPT
29antiphospholipid syndrome10.1CD40LG, F2
30acute kidney failure10.1GPT, AMBP
31alcoholic liver cirrhosis10.1F2, GPT
32galactosemia10.1F2
33common variable immune deficiency10.1CD86, CD40LG
34schistosomiasis10.1CD86, CD40LG
35leukopenia10.1F2, GPT
36lupus erythematosus10.0CD40LG, F2
37vasculitis10.0CD40LG, F2
38sjogren's syndrome10.0CD86, CD40LG
39brain disease10.0F2, GPT
40tetanus10.0CD40LG, CD86
41autoimmune hepatitis10.0CD40LG, GPT, F2
42primary biliary cirrhosis10.0F2, GPT, CD40LG
43thrombocytopenia10.0CD40LG, GPT, F2
44congenital heart disease10.0CD40LG, F2
45diabetes mellitus10.0GPT, AMBP, CD40LG
46acute graft versus host disease10.0TNFRSF4, AMBP
47connective tissue disease10.0CD40LG, CD86, F2
48nodular goiter10.0CD86, TNFRSF4
49liver cirrhosis10.0F2, GPT, HBE1
50myasthenia gravis10.0CD86, TNFRSF4

Graphical network of the top 20 diseases related to Hepatitis E:



Diseases related to hepatitis e

Symptoms for Hepatitis E

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Sources:
8Disease Ontology
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Symptoms:

8 (show all 10)
  • jaundice
  • fatigue
  • loss of appetite
  • nausea
  • vomiting
  • abdominal pain
  • clay-colored bowel movements
  • dark urine
  • joint pain
  • fever

Drugs & Therapeutics for Hepatitis E

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Hepatitis E

Search NIH Clinical Center for Hepatitis E

Genetic Tests for Hepatitis E

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Anatomical Context for Hepatitis E

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Sources:
33MalaCards, 14FMA
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MalaCards organs/tissues related to Hepatitis E:

33
Liver, Kidney, Testes, T cells, Heart, Lung, Thyroid, Brain, Bone, Bone marrow

FMA organs/tissues related to Hepatitis E:

14
Liver

Animal Models for Hepatitis E or affiliated genes

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Publications for Hepatitis E

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Sources:
52PubMed
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Articles related to Hepatitis E:

(show top 50)    (show all 562)
idTitleAuthorsYear
1
Fetal and Neonatal Health Consequences of Vertically Transmitted Hepatitis E Virus Infection. (24420778)
2014
2
Neuralgic amyotrophy and hepatitis E virus infection. (24401685)
2014
3
Chronic hepatitis E: a review of the literature. (24383921)
2014
4
Zoonotic transmission of hepatitis E virus in industrialized countries. (24177295)
2013
5
Marked genomic heterogeneity of rat hepatitis E virus strains in Indonesia demonstrated on a full-length genome analysis. (24231359)
2013
6
Hepatitis E. (23982238)
2013
7
Molecular detection of hepatitis E virus in German domestic pigs. (23367665)
2013
8
No evidence for hepatitis E virus genotype 3 susceptibility in rats. (23876517)
2013
9
Mutagenesis of hepatitis E virus helicase motifs: Effects on enzyme activity. (24333153)
2013
10
Zoonotic and foodborne transmission of hepatitis E virus. (23564388)
2013
11
Epidemiologic concerns and advances in knowledge on hepatitis e. (23961267)
2013
12
Anti hepatitis E virus seropositivity in a group of male blood donors in Makkah, Saudi Arabia. (23894892)
2013
13
Epidemiology of mammalian hepatitis E virus infection. (23343760)
2013
14
Rash and arthralgia caused by hepatitis E. (24290589)
2013
15
A longitudinal study revealing hepatitis E virus infection and transmission at a swine test station. (24119762)
2013
16
Zoonotic hepatitis E virus strains in German blood donors. (22913247)
2013
17
Immunopathogenesis of hepatitis E virus infection. (23564391)
2013
18
Chronic Hepatitis E as a cause for cryptogenic cirrhosis in HIV. (22166370)
2013
19
Test performance characteristics of Anti-HEV IgG assays strongly influence hepatitis E seroprevalence estimates. (23148290)
2013
20
Transmission of hepatitis E virus from rabbits to cynomolgus macaques. (23628346)
2013
21
Avian hepatitis E virus identified in Russian chicken flocks exhibits high genetic divergence based on the ORF2 capsid gene. (22967203)
2012
22
Rat hepatitis E virus: geographical clustering within Germany and serological detection in wild Norway rats (Rattus norvegicus). (22554648)
2012
23
Prolonged jaundice attributed to super infection of hepatitis E virus in a case of resolving leptospirosis. (22361773)
2012
24
The ORF2 glycoprotein of hepatitis E virus inhibits cellular NF-I_B activity by blocking ubiquitination mediated proteasomal degradation of II_BI+ in human hepatoma cells. (22590978)
2012
25
Hepatitis E virus (HEV)-specific T-cell responses are associated with control of HEV infection. (22006345)
2012
26
A retrospective study on imported hepatitis E in Japan. (22405678)
2012
27
Fatal hepatitis E viral infection in pregnant women in Ghana: a case series. (22937872)
2012
28
Chronic hepatitis E infection in children with liver transplantation. (22115826)
2012
29
Hepatitis E virus as a causative agent of unexplained liver enzyme elevations in HIV-infected patients. (22622079)
2012
30
Complete genome sequence of the genotype 4 hepatitis E virus strain prevalent in swine in Jiangsu Province, China, reveals a close relationship with that from the human population in this area. (22787267)
2012
31
Hepatitis E virus: an underdiagnosed cause of chronic hepatitis in renal transplant recipients. (22093456)
2012
32
A naturally occurring human/hepatitis E recombinant virus predominates in serum but not in faeces of a chronic hepatitis E patient and has a growth advantage in cell culture. (22113007)
2012
33
Hepatitis E infection is an under recognized cause of acute decompensation in patients with chronic liver disease. (22592074)
2012
34
Chronic hepatitis E virus infection in a patient with leukemia and elevated transaminases: a case report. (23031738)
2012
35
A549 and PLC/PRF/5 cells can support the efficient propagation of swine and wild boar hepatitis E virus (HEV) strains: demonstration of HEV infectivity of porcine liver sold as food. (22048607)
2012
36
Hepatitis: hepatitis E and decompensated chronic liver disease. (22733353)
2012
37
Presence of hepatitis E RNA in mussels used as bio-monitors of viral marine pollution. (22728271)
2012
38
Identifications of polyphyletic variants in acute hepatitis suggest an underdiagnosed circulation of hepatitis E virus in Argentina. (21795113)
2011
39
Hepatitis E virus ORF2 protein activates the pro-apoptotic gene CHOP and anti-apoptotic heat shock proteins. (21966512)
2011
40
Hepatitis E virus in rats, Los Angeles, California, USA. (22172320)
2011
41
Close similarity between sequences of hepatitis E virus recovered from humans and swine, France, 2008-2009. (22099089)
2011
42
Hepatitis E virus-related acute liver failure associated with pure red cell aplasia. (21947733)
2011
43
Hepatitis E virus infection in macaca mulatta. (22224088)
2011
44
Seroepidemiology and molecular characterization of hepatitis E Virus in Macaca mulatta from a village in Yunnan, China, where infection with this virus is endemic. (22235219)
2011
45
The ORF3 protein of hepatitis E virus delays degradation of activated growth factor receptors by interacting with CIN85 and blocking formation of the Cbl-CIN85 complex. (20130058)
2010
46
Prevalence of hepatitis E virus infection in liver transplant recipients. (19790147)
2009
47
Fulminant hepatic failure in a patient with inactive HBsAg carrier state, acute hepatitis E and thyrotoxicosis. (14585402)
2003
48
Role of immune serum globulins in pregnant women during an epidemic of hepatitis E. (9658374)
1998
49
Acute sporadic hepatitis E virus infection in southern China. (8550986)
1995
50
Persistent and transient antibody responses to hepatitis E virus detected by western immunoblot using open reading frame 2 and 3 and glutathione S-transferase fusion proteins. (7529246)
1994

Variations for Hepatitis E

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Expression for genes affiliated with Hepatitis E

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hepatitis E

Search GEO for disease gene expression data for Hepatitis E.

Pathways for genes affiliated with Hepatitis E

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50PathCards, 60Thomson Reuters, 38NCBI BioSystems Database
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Pathways related to Hepatitis E according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Apoptosis and survival Anti apoptotic TNFs NF kB IAP pathway60
9.5CD40LG, TNFRSF4
29.3CD40LG, CD86

Compounds for genes affiliated with Hepatitis E

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Sources:
45Novoseek, 11DrugBank, 51PharmGKB, 24HMDB, 3BitterDB, 29IUPHAR, 61Tocris Bioscience
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Compounds related to Hepatitis E according to GeneCards/GeneDecks:

(show all 43)
idCompoundScoreTop Affiliating Genes
1ppack4510.1CD40LG, F2
2monoethylglycinexylidide4510.1F2, GPT
3hepaplastin4510.1F2, GPT
4tirofiban45 1111.1CD40LG, F2
5ximelagatran45 1111.1GPT, F2
6aminopyrine4510.1GPT, F2
7abciximab45 1111.1CD40LG, F2
8valproate4510.1CD40LG, GPT
9clopidogrel45 51 24 1113.1CD40LG, F2
10clarithromycin45 1111.1F2, GPT
11mycophenolate mofetil45 51 1112.1GPT, CD40LG
12cardiolipin45 1111.1CD40LG, F2
13hirudin4510.1F2, CD40LG
14fenofibrate45 51 1112.0CD40LG, GPT
15lamivudine45 51 1112.0F2, GPT
16ivig4510.0CD40LG, GPT
17ribavirin45 51 1112.0GPT, CD40LG
18silymarin4510.0GPT, F2
19vitamin b124510.0GPT, CD40LG
20trichloroethylene4510.0GPT, AMBP
21neopterin4510.0CD40LG, GPT
22warfarin45 51 24 1112.9GPT, F2
23calcium oxalate459.9F2, AMBP
24acetaminophen45 3 51 24 1113.8F2, GPT
25pge1459.8GPT, F2
26kininogen459.8AMBP, F2
27ursodeoxycholic acid45 24 1111.8CD40LG, GPT, F2
28n acetylcysteine459.7CD40LG, GPT, F2
29il-12459.7CD86, CD40LG
30polyethylene glycol459.6CD40LG, F2
31vitamin a45 24 1111.6CD40LG, AMBP, GPT
32aprotinin45 1110.6AMBP, F2
33uric acid45 2410.6GPT, AMBP
34allergens459.5CD40LG, CD86
35pravastatin45 51 29 24 1113.5CD40LG, GPT
36hyaluronic acid45 2410.3F2, GPT, AMBP, CD40LG
37fibrinogen459.3F2, GPT, AMBP, CD40LG
38lactate459.2CD40LG, AMBP, GPT, F2
39creatinine459.2F2, GPT, AMBP, CD40LG
40aspartate459.2CD40LG, AMBP, GPT, F2
41alanine459.2F2, GPT, AMBP, CD40LG
42sodium dodecylsulfate459.1CD86, AMBP
43cyclosporin a45 29 619.8CD40LG, CD86, AMBP, TNFRSF4, GPT, F2

GO Terms for genes affiliated with Hepatitis E

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16Gene Ontology
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Cellular components related to Hepatitis E according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:0725628.7AMBP, HBE1, F2
2external side of plasma membraneGO:0098978.7CD40LG, CD86, TNFRSF4

Biological processes related to Hepatitis E according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1viral processGO:0160328.7CD86, RPS17, AMBP

Products for genes affiliated with Hepatitis E

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hepatitis E

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet