MCID: HPT007
MIFTS: 50

Hepatitis E malady

Summaries for Hepatitis E

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A viral infectious disease that results in inflammation located in liver, has material basis in hepatitis e virus, which is transmitted by ingestion of contaminated food. the infection has symptom fever, has symptom fatigue, has symptom loss of appetite, has symptom nausea, has symptom vomiting, has symptom abdominal pain, has symptom clay-colored bowel movements, has symptom dark urine, has symptom joint pain, and has symptom jaundice.

MalaCards: Hepatitis E is related to hepatitis and hepatitis a, and has symptoms including jaundice, abdominal pain and loss of appetite. An important gene associated with Hepatitis E is CD40LG (CD40 ligand), and among its related pathways are Common Pathway and Activation of Genes by ATF4. The compounds ursodeoxycholic acid and hirudin have been mentioned in the context of this disorder. Affiliated tissues include liver, liver and kidney, and related mouse phenotype endocrine/exocrine gland.

Wikipedia:63 Hepatitis E is a viral hepatitis (liver inflammation) caused by infection with a virus called hepatitis... more...

Aliases & Classifications for Hepatitis E

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH
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Aliases & Descriptions:

hepatitis e 8 42 10 44 60


External Ids:

Disease Ontology8 DOID:4411
MeSH34 D016751

Related Diseases for Hepatitis E

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Hepatitis C family:

hepatitis e Hepatitis B
Autoimmune Hepatitis Hepatitis D
Hepatitis a Hepatitis
Viral Hepatitis Hepatitis C Virus

Diseases related to Hepatitis E via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 70)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis31.9F2, HELLS, CD40LG, CD99, HBE1, GPT
2hepatitis a31.5F2, HBE1
3viral hepatitis30.8F2, GPT
4acute liver failure30.6F2, GPT
5hepatitis b30.4F2, GPT, HBE1
6autoimmune hepatitis30.4F2, GPT, CD40LG
7hepatitis c30.2F2, GPT, CD40LG, HELLS
8leukemia30.2HELLS, SAFB, DDIT3, HCK, CD40LG, CD99
9hepatitis d29.9HBE1
10cryoglobulinemia29.9CD40LG
11malaria29.9AMBP
12guillain-barre syndrome10.2
13autoimmune hemolytic anemia10.2
14drug-induced hepatitis10.2
15hemolytic anemia10.2
16liver disease10.2
17acute pancreatitis10.1
18hepatic encephalopathy10.1
19pancreatitis10.1
20cryoglobulinemic vasculitis10.0CD40LG
21acquired immunodeficiency syndrome10.0HCK
22cholecystitis10.0GPT
23thromboembolism10.0F2
24deficiency anemia10.0HBE1, F2
25alpha thalassemia10.0HBE1
26arthritis10.0HPX, AMBP
27myocardial infarction10.0FGB
28pyelonephritis10.0AMBP
29cholelithiasis10.0GPT
30hypercholesterolemia10.0GPT
31blood protein disease10.0F2, CD40LG
32diabetes mellitus10.0AMBP, CD40LG, GPT
33rheumatoid arthritis10.0HPX, CD40LG, AMBP
34pulmonary embolism10.0FGB, F2
35disseminated intravascular coagulation10.0F2
36nephrotic syndrome10.0AMBP
37primary biliary cirrhosis10.0F2, GPT, CD40LG
38ischemia10.0ATF4
39dysfibrinogenemia10.0F2
40choroid plexus carcinoma10.0SPAG11A, SPAG11B
41infertility10.0AMBP
42sarcoma10.0HELLS, DDIT3, CD99
43hepatocellular carcinoma10.0DDIT3, HBE1, GPT, F2, TSG101
44biliary atresia10.0GPT
45myeloma10.0DDIT3, CD40LG
46dengue hemorrhagic fever10.0CD40LG
47ipex syndrome10.0HELLS, HCK, CD40LG, GPT, TSG101
48atherosclerosis10.0CD40LG, HPX
49breast cancer10.0TSG101, ATF4, DDIT3, SAFB, HELLS, AMBP
50afibrinogenemia10.0F2, FGB

Graphical network of the top 20 diseases related to Hepatitis E:



Diseases related to hepatitis e

Clinical Features for Hepatitis E

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8Disease Ontology
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Symptoms:

8 (show all 10)
  • jaundice
  • abdominal pain
  • loss of appetite
  • nausea
  • fatigue
  • vomiting
  • clay-colored bowel movements
  • joint pain
  • dark urine
  • fever

Drugs & Therapeutics for Hepatitis E

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Hepatitis E

Drug clinical trials:

Search ClinicalTrials for Hepatitis E

Search NIH Clinical Center for Hepatitis E

Search CenterWatch for Hepatitis E

Genetic Tests for Hepatitis E

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Anatomical Context for Hepatitis E

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Hepatitis E:

32
Liver, Kidney, T cells, Testes, Thyroid, Heart, Bone, Brain, Lung, Bone marrow, Monocytes, Endothelial, Colon

FMA organs/tissues related to Hepatitis E:

14
Liver

Animal Models for Hepatitis E or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Hepatitis E:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537910.0TSG101, ASZ1, CD40LG, DDIT3, SAFB, AMBP

Publications for Hepatitis E

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50PubMed
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Articles related to Hepatitis E:

(show top 50)    (show all 775)
idTitleAuthorsYear
1
Comparison of real-time reverse transcriptase (RT)-PCR assays for detection of swine hepatitis E virus in fecal samples. (24430450)
2014
2
Host immune status and response to hepatitis e virus infection. (24396140)
2014
3
Antiviral strategies for hepatitis E virus. (24374149)
2014
4
Hepatitis E. (23982238)
2013
5
Epidemiology of mammalian hepatitis E virus infection. (23343760)
2013
6
The clinical course of hepatitis E virus infection in patients of a tertiary Dutch hospital over a 5-year period. (24055152)
2013
7
Comparison of real-time RT-PCR assays for hepatitis E virus RNA detection. (23886501)
2013
8
Detection and characterisation of hepatitis E virus in naturally infected swine in Croatia. (23974940)
2013
9
Comparison of hepatitis E virus genotypes from rabbits and pigs in the same geographic area: no evidence of natural cross-species transmission between the two animals. (23183309)
2013
10
A novel indirect immunofluorescence test for the detection of IgG and IgA antibodies for diagnosis of Hepatitis E Virus infections. (23557668)
2013
11
Chronic hepatitis E resolution in a human immunodeficiency virus (HIV)-infected patient treated with ribavirin. (23507411)
2013
12
Effect of HLA-DP and IL28B gene polymorphisms on response to interferon treatment in hepatitis B e-antigen seropositive chronic hepatitis B patients. (24298935)
2013
13
Hepatitis E virus infection in a liver transplant recipient in the United States: a case report. (23498824)
2013
14
Avian hepatitis E virus identified in Russian chicken flocks exhibits high genetic divergence based on the ORF2 capsid gene. (22967203)
2012
15
A549 and PLC/PRF/5 cells can support the efficient propagation of swine and wild boar hepatitis E virus (HEV) strains: demonstration of HEV infectivity of porcine liver sold as food. (22048607)
2012
16
Detection and molecular characterization of hepatitis E virus in clinical, environmental and putative animal sources. (22847755)
2012
17
Hepatitis E virus-induced severe myositis. (22641093)
2012
18
Genotype 3f predominance in symptomatic acute autochthonous hepatitis E: a short case series in south-eastern France. (22521756)
2012
19
Cirrhosis due to chronic hepatitis E infection in a child post-bone marrow transplant. (22341950)
2012
20
Cytokine profiles, CTL response and T cell frequencies in the peripheral blood of acute patients and individuals recovered from hepatitis E infection. (22384080)
2012
21
Hepatitis C virus attachment mediated by apolipoprotein E binding to cell surface heparan sulfate. (22532692)
2012
22
Systematic screening for novel, serologically reactive Hepatitis E Virus epitopes. (22269698)
2012
23
Hepatitis E virus infection among solid organ transplant recipients, the Netherlands. (22516170)
2012
24
New findings regarding the epidemic history and population dynamics of Japan-indigenous genotype 3 hepatitis E virus inferred by molecular evolution. (22181032)
2012
25
Epidemiological and virological characteristics of symptomatic acute hepatitis E in Greater Cairo, Egypt. (22264267)
2012
26
Hepatitis E virus genotype 3 in shellfish, United Kingdom. (23171845)
2012
27
Evolution of the hepatitis E virus hypervariable region. (22837418)
2012
28
Hepatitis E virus infection causing isolated fetal ascites: a case report. (22677891)
2012
29
Prevalence of hepatitis E and hepatitis B dual infection in North India (Delhi). (23762995)
2012
30
Molecular epidemiology and genetic history of European-type genotype 3 hepatitis E virus indigenized in the central region of Japan. (22706162)
2012
31
Seroepidemiology and molecular characterization of hepatitis E Virus in Macaca mulatta from a village in Yunnan, China, where infection with this virus is endemic. (22235219)
2011
32
Hepatitis E virus seroprevalence among blood donors in southwest Switzerland. (21701586)
2011
33
Identification of genotype 4 Hepatitis E virus binding proteins on swine liver cells. (22029540)
2011
34
Seroprevalence and molecular detection of hepatitis E virus in Yunnan Province, China. (21874521)
2011
35
Thermal stability of hepatitis E virus assessed by a molecular biological approach. (22040359)
2011
36
High viral load and deregulation of the progesterone receptor signaling pathway: association with hepatitis E-related poor pregnancy outcome. (21145845)
2011
37
Investigating an outbreak of acute viral hepatitis caused by hepatitis E virus variants in Karachi, South Pakistan. (21328376)
2011
38
Seroprevalence of hepatitis a and e viruses based on the third Korea national health and nutrition survey in Korea. (24159450)
2011
39
Treatment of chronic hepatitis E in liver transplant recipients with pegylated interferon alpha-2b. (20373458)
2010
40
Clinical features and predictors of outcome in acute hepatitis A and hepatitis E virus hepatitis on cirrhosis. (19267864)
2009
41
Hepatitis E virus coinfection with hepatotropic viruses in Egyptian children. (18629421)
2008
42
The ORF3 protein of hepatitis E virus interacts with hemopexin by means of its 26 amino acid N-terminal hydrophobic domain II. (18211098)
2008
43
Vitamin E and C supplementation prevents decrease of eicosapentaenoic acid in mononuclear cells in chronic hepatitis C patients during combination therapy of interferon alpha-2b and ribavirin. (16459223)
2006
44
Molecular characterization of hepatitis E virus in three acute liver failure cases in children in Argentina]. (17407988)
2006
45
Apolipoprotein E enhances hepatic lipase-mediated hydrolysis of reconstituted high-density lipoprotein phospholipid and triacylglycerol in an isoform-dependent manner. (15379569)
2004
46
Genetic identification of avian hepatitis E virus (HEV) from healthy chicken flocks and characterization of the capsid gene of 14 avian HEV isolates from chickens with hepatitis-splenomegaly syndrome in different geographical regions of the United States. (14993655)
2004
47
Adefovir dipivoxil for the treatment of hepatitis B e antigen-negative chronic hepatitis B. (12606734)
2003
48
Long-term evaluation of recombinant interferon alpha2b in the treatment of patients with hepatitis B e antigen-negative chronic hepatitis B in Taiwan. (11703575)
2001
49
The ORF3 protein of hepatitis E virus binds to Src homology 3 domains and activates MAPK. (11518702)
2001
50
Hepatitis B e antigen seroconversion: effects of lamivudine alone or in combination with interferon alpha. (10861649)
2000

Genetic Variations for Hepatitis E

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Expression for genes affiliated with Hepatitis E

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hepatitis E

Search GEO for disease gene expression data for Hepatitis E.

Pathways for genes affiliated with Hepatitis E

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53Reactome, 51QIAGEN
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Pathways related to Hepatitis E according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4F2, FGB
2
Hide members
10.3ATF4, DDIT3

Compounds for genes affiliated with Hepatitis E

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Hepatitis E according to GeneCards/GeneDecks:

(show all 25)
idCompoundScoreTop Affiliating Genes
1ursodeoxycholic acid44 11 2412.6F2, GPT, CD40LG
2hirudin4410.6CD40LG, FGB, F2
3monoethylglycinexylidide4410.6GPT, F2
4batroxobin4410.6FGB, F2
5ribavirin44 49 1112.6HELLS, CD40LG, GPT
6hepaplastin4410.6GPT, F2
7ximelagatran44 1111.6F2, GPT
8hyaluronic acid44 2411.6AMBP, CD40LG, HPX, GPT, F2
9calcium oxalate4410.5AMBP, F2
10vitamin a44 11 2412.5GPT, HPX, CD40LG, AMBP
11nacl4410.5HELLS, HPX, FGB, SPAG11B
12n acetylcysteine4410.5DDIT3, ATF4, CD40LG, GPT, F2
13aminopyrine4410.5GPT, F2
14fibrinogen4410.4F2, GPT, FGB, HPX, CD40LG, HCK
15serine4410.4AMBP, HELLS, SAFB, ATF4, HPX
16cisplatin44 49 59 1113.4CD40LG, ATF4, DDIT3, HELLS, AMBP
17alanine4410.4C16orf80, AMBP, HELLS, SAFB, CD40LG, GPT
18ppack4410.4F2, CD40LG
19leucine4410.4AMBP, HELLS, SAFB, DDIT3, ATF4, TSG101
20retinoic acid44 2411.3C16orf80, AMBP, HELLS, SAFB, DDIT3, HCK
21vitamin d4410.3GPT, HPX, SAFB, C16orf80
22asparagine4410.3GPT, ATF4, DDIT3
23trichloroethylene4410.3AMBP, GPT
24homocysteine44 2411.3F2, ATF4, DDIT3
25amantadine44 1111.1GPT, HELLS

GO Terms for genes affiliated with Hepatitis E

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16Gene Ontology
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Biological processes related to Hepatitis E according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressGO:07005910.3ATF4, DDIT3
2viral processGO:01603210.1TSG101, HCK, VPS4A, RPS17
3modulation by virus of host morphology or physiologyGO:0190489.9AMBP, HCK, HPX, TSG101

Products for genes affiliated with Hepatitis E

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hepatitis E

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet