HBL
MCID: HPT022
MIFTS: 56

Hepatoblastoma (HBL) malady

Liver, Cancer categories

Summaries for Hepatoblastoma

Sources:
64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:64 Hepatoblastoma is an uncommon malignant liver neoplasm occurring in infants and children and composed of... more...

MalaCards: Hepatoblastoma, also known as HBL, is related to beckwith-wiedemann syndrome and adenoma. An important gene associated with Hepatoblastoma is AXIN1 (axin 1), and among its related pathways are Wnt / Hedgehog / Notch and Rho Family GTPases. The compounds oligonucleotide and progesterone have been mentioned in the context of this disorder. Related mouse phenotypes are homeostasis/metabolism and mortality/aging.

Aliases & Classifications for Hepatoblastoma

Sources:
8Disease Ontology, 43NIH Rare Diseases, 22GTR, 10DISEASES, 45Novoseek, 49Orphanet, 61UMLS, 40NCIt, 57SNOMED-CT, 35MeSH, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 36MESH via Orphanet, 26ICD10 via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Liver


Characteristics (Orphanet epidemiological data):

49
hepatoblastoma:
Inheritance: Sporadic; Age of onset: Childhood


Aliases & Descriptions:

hepatoblastoma 8 43 22 10 45 49 61
hbl 8


External Ids:

Disease Ontology8 DOID:687
NCIt40 C3728
MeSH35 D018197
SNOMED-CT via Orphanet58 45024009, 109843000
SNOMED-CT57 109843000, 45024009
UMLS via Orphanet62 C0206624
MESH via Orphanet36 D018197
ICD10 via Orphanet26 C22.2

Related Diseases for Hepatoblastoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Hepatoblastoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 123)
idRelated DiseaseScoreTop Affiliating Genes
1beckwith-wiedemann syndrome30.7H19, IGF2, CDKN1C, SLC22A18
2adenoma30.6H19, APC, CTNNB1, IGF2, CDKN1C, AXIN2
3familial adenomatous polyposis30.6AXIN2, AXIN1, DKK1, CTNNB1, APC
4hemihypertrophy30.3H19, IGF2, CDKN1C
5adenocarcinoma30.2H19, APC, CTNNB1, AFP, CDKN1C, AXIN1
6wilms tumor30.2H19, CTNNB1, IGF2, CDKN1C, SLC22A18
7rhabdoid tumor30.2IGF2
8acute leukemia30.0THPO, EPOR, MPL
9hepatocellular adenoma29.8APC, CTNNB1, AFP
10hypoglycemia29.8SERPINA6, CDKN1C, IGF2
11gardner syndrome29.8APC, CTNNB1
12biliary atresia29.8SLC10A1, OTC
13pancytopenia29.8MPL, THPO
14thrombocytosis29.8THPO, EPOR, MPL
15erythrocytosis29.8EPOR, MPL
16mixed hepatoblastoma10.5
17hepatitis c10.4
18hepatitis c virus10.3
19hepatitis a10.3
20hypobetalipoproteinemia, familial, 210.3
21hepatitis e10.2
22hepatoblastoma, somatic10.2
23macrotrabecular hepatoblastoma10.1
24aicardi syndrome10.1
25hepatitis d10.1
26teratoma10.1
27cystic fibrosis10.0
28gastrointestinal stromal tumor10.0
29n syndrome10.0
30simpson-golabi-behmel syndrome10.0
31precocious puberty10.0
32hemangioendothelioma10.0
33hepatocellular carcinoma, somatic10.0
34hepatocellular carcinoma10.0H19, APC, CTNNB1, MGAT3, AFP, IGF2
35breast cancer10.0H19, APC, CTNNB1, IGF2, DKK1, CDKN1C
36colorectal cancer10.0H19, APC, CTNNB1, IGF2, DKK1, CDKN1C
37leukemia10.0H19, MGAT3, MPL, CDKN1C, EPOR, PLAG1
38prostate cancer10.0APC, CTNNB1, IGF2, DKK1, AXIN1, EPOR
39stomach cancer10.0H19, APC, CTNNB1, AFP, CDKN1C, EPOR
40choriocarcinoma10.0H19, AFP, IGF2, CDKN1C, EPOR
41squamous cell carcinoma10.0H19, APC, CTNNB1, CDKN1C, AXIN1, EPOR
42chronic myeloid leukemia10.0H19, MPL, CDKN1C, EPOR, THPO
43ovarian cancer10.0IGF2, AFP, CTNNB1, H19
44colon cancer10.0APC, CTNNB1, IGF2, AXIN2, EPOR
45liver cirrhosis10.0MGAT3, MPL, AFP, THPO
46myeloproliferative disorder10.0THPO, EPOR, MPL, H19
47gastric adenocarcinoma10.0APC, CTNNB1, AFP, EPOR
48endometrial carcinoma10.0APC, CTNNB1, IGF2, SERPINA6
49pancreatic cancer10.0CDKN1C, DKK1, CTNNB1
50refractory anemia10.0THPO, EPOR, MPL

Graphical network of the top 20 diseases related to Hepatoblastoma:



Diseases related to hepatoblastoma

Clinical Features for Hepatoblastoma

Drugs & Therapeutics for Hepatoblastoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Hepatoblastoma

Drug clinical trials:

Search ClinicalTrials for Hepatoblastoma

Search NIH Clinical Center for Hepatoblastoma

Search CenterWatch for Hepatoblastoma

Genetic Tests for Hepatoblastoma

Sources:
22GTR
See all sources

Genetic tests related to Hepatoblastoma:

id Genetic test Affiliating Genes
1 Hepatoblastoma22

Anatomical Context for Hepatoblastoma

Animal Models for Hepatoblastoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Hepatoblastoma:

37 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537611.8MPL, MGAT3, CTNNB1, APC, H19, AFP
2MP:001076811.7H19, APC, CTNNB1, MPL, AFP, IGF2
3MP:000538011.7H19, APC, CTNNB1, MPL, IGF2, DKK1
4MP:000538411.5H19, APC, CTNNB1, MGAT3, MPL, IGF2
5MP:000538211.5H19, APC, CTNNB1, IGF2, DKK1, CDKN1C
6MP:000536711.5H19, APC, CTNNB1, IGF2, DKK1, CDKN1C
7MP:000538511.4H19, APC, CTNNB1, IGF2, CDKN1C, CDO1
8MP:000537011.3H19, APC, CTNNB1, MGAT3, IGF2, EPOR
9MP:000537911.3H19, AFP, CDKN1C, CDO1, AXIN2, PLAG1
10MP:000537811.3H19, APC, CTNNB1, MPL, IGF2, CDKN1C
11MP:000538911.3APC, CTNNB1, AFP, CDKN1C, CDO1, PLAG1
12MP:000539011.3H19, APC, DKK1, CDKN1C, CDO1, AXIN1
13MP:000287311.2H19, APC, CTNNB1, MGAT3, CDKN1C, AXIN1
14MP:000539111.2H19, APC, DKK1, CDO1, AXIN2, PLAG1
15MP:000538611.2APC, CTNNB1, AFP, IGF2, CDKN1C, CDO1
16MP:000537111.1AXIN2, CDO1, DKK1, H19
17MP:000538711.1APC, CTNNB1, MPL, IGF2, CDKN1C, EPOR
18MP:000538811.0CTNNB1, IGF2, DKK1, CDO1, AXIN1, EPOR
19MP:000363111.0APC, DKK1, AXIN1, AXIN2, OTC
20MP:000301210.9APC, CTNNB1, IGF2, EPOR, SERPINA6, H19
21MP:000539710.8APC, CTNNB1, MPL, IGF2, CDKN1C, EPOR

Publications for Hepatoblastoma

Sources:
51PubMed
See all sources

Articles related to Hepatoblastoma:

(show top 50)    (show all 666)
idTitleAuthorsYear
1
Hepatoblastoma evaluated by 18F-fluoromethyl choline PET/CT. (23334143)
2013
2
CDX2 highlights mucinous epithelium in hepatoblastoma with teratoid components. (23003007)
2013
3
Clinicopathologic implication of hepatic progenitor cell marker expression in hepatoblastoma. (23920322)
2013
4
BH3-mimetic drugs prevent tumour onset in an orthotopic mouse model of hepatoblastoma. (24355809)
2013
5
Left atrial extension of hepatoblastoma via left superior pulmonary vein. (24229501)
2013
6
SALL4 is a marker of the embryonal subtype of hepatoblastoma. (23822878)
2013
7
MAPK signaling pathways regulate mitochondrial-mediated apoptosis induced by isoorientin in human hepatoblastoma cancer cells. (23220614)
2013
8
Hepatoblastoma in an infant with paternal uniparental disomy 14. (23181499)
2012
9
Chronic biloma after right hepatectomy for stage IV hepatoblastoma managed with Roux-en-Y biliary cystenterostomy. (23164033)
2012
10
Major liver resection by a hanging maneuver for an infant with hepatoblastoma. (23569511)
2012
11
Can we predict the prognosis of resectable hepatoblastoma from serum alpha-fetoprotein response during preoperative chemotherapy? (22948667)
2012
12
Extended hepatic resection in advanced hepatoblastoma. (22201886)
2012
13
Over-expression of SERPINB3 in hepatoblastoma: a possible insight into the genesis of this tumour? (21737255)
2012
14
Development of a drug resistance model for hepatoblastoma. (21132272)
2011
15
Hepatoblastoma: Analysis of treatment outcome from a tertiary care center. (21430841)
2011
16
Surgery for hepatoblastoma: from laparoscopic resection to liver transplantation. (21830412)
2011
17
Hepatoblastoma in association with bilateral polycystic kidneys. (21034924)
2010
18
A child with an FGFR3 mutation, a laterality disorder and an hepatoblastoma: novel associations and possible gene-environment interactions. (20707699)
2010
19
Genome-wide analysis of allelic imbalances reveals 4q deletions as a poor prognostic factor and MDM4 amplification at 1q32.1 in hepatoblastoma. (20461752)
2010
20
Arachidonic Acid Activates K-Cl-cotransport in HepG2 Human Hepatoblastoma Cells. (19915704)
2009
21
Hypoplastic glomerulocystic kidney disease and hepatoblastoma: a potential association not caused by mutations in hepatocyte nuclear factor 1beta. (19564751)
2009
22
Patterns of hepatoblastoma and hepatocellular carcinoma in children after universal hepatitis B vaccination in taiwan: a report from a single institution in southern Taiwan. (19194190)
2009
23
Three equine cases of mixed hepatoblastoma with teratoid features. (17317799)
2007
24
Application of the human hepatoblastoma cell lines inducibly expressing peroxisome proliferator-activated receptors (PPARs)]. (17666873)
2007
25
Expression of a liver-specific function by a hepatoblastoma cell line cocultured with three-dimensional endothelialized tubes in collagen gels. (17368405)
2007
26
Evaluation and treatment of hepatoblastoma. (16423617)
2006
27
Targeting the MDM2 gene using antisense oligonucleotide to induce cell apoptosis in human hepatoblastoma cell line HepG2]. (17064483)
2006
28
Maternal and infant birth characteristics and hepatoblastoma. (16510543)
2006
29
Should children at risk for familial adenomatous polyposis be screened for hepatoblastoma and children with apparently sporadic hepatoblastoma be screened for APC germline mutations? (16317745)
2006
30
Response of heavily treated and relapsed hepatoblastoma in the transplanted liver to single-agent therapy with irinotecan. (16857004)
2006
31
Prenatal imaging of fetal hepatoblastoma. (16076626)
2005
32
The tamoxifen-induced suppression of telomerase activity in the human hepatoblastoma cell line HepG2: a result of post-translational regulation. (15503139)
2005
33
Successful treatment of doxorubicin and cisplatin resistant hepatoblastoma in a child with Beckwith-Wiedemann syndrome with high dose acetaminophen and N-acetylcysteine rescue. (15770640)
2005
34
New trends in tumor biology: transfection of a human hepatoblastoma cell line with green fluorescent protein. (15852273)
2005
35
Sirolimus for pediatric liver transplant recipients with post-transplant lymphoproliferative disease and hepatoblastoma. (15176961)
2004
36
A trend of improved survival of childhood hepatoblastoma treated with cisplatin and doxorubicin in Taiwanese children. (14556026)
2003
37
Orthotopic liver transplantation for unresectable hepatoblastoma. (12352881)
2002
38
Stem-like cells in hepatoblastoma. (12228907)
2002
39
Modern treatment of childhood hepatoblastoma: what do clinicians and pathologists have to say to each other? (12228902)
2002
40
Frequent deletions and mutations of the beta-catenin gene are associated with overexpression of cyclin D1 and fibronectin and poorly differentiated histology in childhood hepatoblastoma. (11309340)
2001
41
omega-hydroxylation activity toward leukotriene B(4) and polyunsaturated fatty acids in the human hepatoblastoma cell line, HepG2, and human lung adenocarcinoma cell line, A549. (11056396)
2000
42
p57(KIP2) is not mutated in hepatoblastoma but shows increased transcriptional activity in a comparative analysis of the three imprinted genes p57(KIP2), IGF2, and H19. (11021841)
2000
43
A case of well-differentiated, fetal-type hepatoblastoma with very low serum alpha-fetoprotein. (10626849)
1999
44
Copper resistant human hepatoblastoma mutant cell lines without metallothionein induction overexpress ATP7B. (9794921)
1998
45
Differential regulation of p53, c-Myc, Bcl-2 and Bax protein expression during apoptosis induced by widely divergent stimuli in human hepatoblastoma cells. (8760302)
1996
46
Insulin-like growth factor 2 and insulin-like growth factor binding protein 2 expression in hepatoblastoma. (7543440)
1995
47
Regulation of ferritin expression by alcohol in a human hepatoblastoma cell line and in rat hepatocyte cultures. (8655961)
1995
48
The modulation of the phenotype of the human hepatoblastoma cell line HepG2 under the action of dimethyl sulfoxide]. (7690467)
1993
49
A novel human hepatoblastoma cell line (HuH-6KK) with rapid growth in serum-free medium without extracellular matrix. (1369296)
1990
50
The effect of HMG-CoA reductase inhibitor (CS-514) on the synthesis and secretion of apolipoproteins B and A-1 in the human hepatoblastoma Hep G2. (2153411)
1990

Genetic Variations for Hepatoblastoma

Expression for genes affiliated with Hepatoblastoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Hepatoblastoma

Search GEO for disease gene expression data for Hepatoblastoma.

Pathways for genes affiliated with Hepatoblastoma

Sources:
4Cell Signaling Technology, 52QIAGEN, 30KEGG, 53R&D Systems, 38NCBI BioSystems Database, 60Tocris Bioscience, 12EMD Millipore, 54Reactome
See all sources

Pathways related to Hepatoblastoma according to GeneCards/GeneDecks:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.9AXIN2, AXIN1, DKK1, AFP, CTNNB1, APC
2
Hide members
10.9APC, CTNNB1, IGF2, AXIN1, EPOR, THPO
3
Hide members
10.9APC, CTNNB1, IGF2, AXIN1, EPOR, THPO
410.9AXIN2, AXIN1, AFP, CTNNB1, APC
5
Hide members
10.9APC, CTNNB1, DKK1, AXIN1, AXIN2
610.8AXIN2, AXIN1, CTNNB1, APC
7
Hide members
10.8APC, CTNNB1, AXIN1, AXIN2
8
Hide members
10.8APC, CTNNB1, AXIN1, AXIN2
9
Hide members
10.8APC, CTNNB1, AXIN1, AXIN2
1010.8APC, CTNNB1, AXIN1, AXIN2
1110.8AXIN1, IGF2, CTNNB1, APC
12
Hide members
10.8AXIN1, DKK1, CTNNB1, APC
1310.8APC, CTNNB1, DKK1, AXIN1
1410.8APC, CTNNB1, DKK1, AXIN1
1510.8APC, CTNNB1, DKK1, AXIN1
1610.8APC, CTNNB1, DKK1, AXIN2
17
Hide members
10.7AXIN1, CTNNB1, APC
18
Cytoskeleton remodeling Reverse signaling by ephrin B
Hide members
10.7AXIN2, AXIN1, CTNNB1
1910.7CTNNB1, AXIN1, AXIN2
20
Hide members
10.7MGAT3, IGF2, AXIN1

Compounds for genes affiliated with Hepatoblastoma

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB
See all sources

Compounds related to Hepatoblastoma according to GeneCards/GeneDecks:

(show top 50)    (show all 61)
idCompoundScoreTop Affiliating Genes
1oligonucleotide4511.6APC, CTNNB1, AFP, IGF2, CDO1, EPOR
2progesterone45 60 29 11 2415.5APC, CTNNB1, UGT2B4, AFP, IGF2, DKK1
3steroid4511.5H19, CTNNB1, UGT2B4, AFP, IGF2, EPOR
4retinoic acid45 2412.5H19, APC, CTNNB1, MGAT3, UGT2B4, AFP
5agar4511.5THPO, H19, CTNNB1, MPL, AFP, IGF2
6glycogen45 2412.5APC, CTNNB1, AFP, IGF2, DKK1, AXIN2
7testosterone45 60 11 2414.4APC, CTNNB1, UGT2B4, AFP, IGF2, SLC10A1
8alanine4511.4CTNNB1, MPL, AFP, IGF2, EPOR, THPO
9serine4511.4APC, CTNNB1, MPL, AFP, IGF2, AXIN2
105-aza-2deoxycytidine4511.4H19, APC, CTNNB1, IGF2, CDKN1C, THPO
115fluorouracil4511.4CTNNB1, MPL, AFP, IGF2, THPO, OTC
12cysteine4511.4CTNNB1, MPL, IGF2, CDO1, EPOR, THPO
13paraffin4511.4H19, APC, CTNNB1, AFP, IGF2, EPOR
14thymidine45 2412.3H19, CTNNB1, AFP, IGF2, EPOR, THPO
15tyrosine4511.3H19, APC, CTNNB1, MPL, AFP, IGF2
16acth4511.3H19, APC, IGF2, CDKN1C, SERPINA6
17tamoxifen45 50 29 1114.2CTNNB1, UGT2B4, IGF2, THPO, SERPINA6
18vegf4511.2CTNNB1, MPL, AFP, IGF2, EPOR, THPO
19methylcellulose4511.2CTNNB1, IGF2, EPOR, THPO
20phosphatidylinositol4511.2APC, CTNNB1, MPL, IGF2, EPOR, THPO
21polyethylene glycol4511.2MPL, AFP, IGF2, THPO
22estrone45 29 11 2414.2UGT2B4, AFP, IGF2, SERPINA6
23glutamine4511.2APC, CTNNB1, AFP, IGF2, OTC
24threonine4511.2APC, CTNNB1, MPL, AFP, AXIN2, OTC
25iron45 2412.2MPL, AFP, CDO1, EPOR, THPO
26samp4511.2APC, CTNNB1, AXIN2
27glucose4511.1APC, IGF2, OTC, SERPINA6
28sodium bisulfite4511.1IGF2, CTNNB1, APC
29tgf beta14511.1THPO, IGF2, AFP, CTNNB1
30rsai4511.1OTC, IGF2, H19
31fatty acid4511.1APC, CTNNB1, OTC, SERPINA6
32sodium45 2412.0APC, AFP, THPO, SLC10A1, OTC
33butyrate4511.0OTC, THPO
34methylazoxymethanol acetate4511.0APC, CTNNB1
351-hydroxyanthraquinone4511.0APC, CTNNB1
36pidotimod4511.0CTNNB1, AXIN2
37megapoietin4511.0MPL, THPO
38sialic acid4511.0PLAG1, THPO
39aspirin45 50 29 2414.0THPO, MPL, CTNNB1, APC
40estrogen4511.0THPO
41dihydrotestosterone45 29 11 2414.0SERPINA6, UGT2B4
42nap-24511.0H19, IGF2
431,2-dimethylhydrazine4510.9APC, CTNNB1
44apai4510.8IGF2, H19
45azoxymethane4510.7APC, CTNNB1
46lithium45 50 11 2413.7DKK1, CTNNB1, APC
47acth 1-244510.7IGF2, SERPINA6
482-amino-3-methylimidazo(4,5-f)quinoline4510.6CTNNB1, APC
49anagrelide45 1111.5MPL, THPO
50indomethacin45 60 29 1113.5SLC10A1, THPO, IGF2, APC

GO Terms for genes affiliated with Hepatoblastoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Hepatoblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1beta-catenin destruction complexGO:03087710.8AXIN2, AXIN1, CTNNB1, APC
2cell cortexGO:00593810.7AXIN2, AXIN1, CTNNB1
3lateral plasma membraneGO:01632810.6APC, CTNNB1, AXIN1
4cytoplasmic microtubuleGO:00588110.4AXIN2, AXIN1, APC

Biological processes related to Hepatoblastoma according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of canonical Wnt receptor signaling pathwayGO:09009010.9AXIN2, AXIN1, DKK1, APC
2Wnt receptor signaling pathway involved in somitogenesisGO:09024410.9AXIN2, AXIN1, DKK1
3dorsal/ventral axis specificationGO:00995010.9CTNNB1, AXIN1, AXIN2
4regulation of centromeric sister chromatid cohesionGO:07060210.7CTNNB1, AXIN2
5cytoplasmic microtubule organizationGO:03112210.6AXIN1, APC
6midgut developmentGO:00749410.6OTC, CTNNB1
7canonical Wnt receptor signaling pathwayGO:06007010.6APC, CTNNB1, AXIN1
8positive regulation of protein phosphorylationGO:00193410.4AXIN2, AXIN1, IGF2

Molecular functions related to Hepatoblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein kinase bindingGO:01990110.8AXIN2, AXIN1, CTNNB1, APC
2I-SMAD bindingGO:07041110.8AXIN2, AXIN1, CTNNB1
3beta-catenin bindingGO:00801310.7AXIN2, AXIN1, APC
4signal transducer activityGO:00487110.7CTNNB1, DKK1, AXIN1, AXIN2
5armadillo repeat domain bindingGO:07001610.3AXIN2, AXIN1

Products for genes affiliated with Hepatoblastoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hepatoblastoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet