MCID: HPT022
MIFTS: 61

Hepatoblastoma malady

Rare diseases, Liver diseases, Cancer diseases categories

Summaries for Hepatoblastoma

About this section


Wikipedia:65 Hepatoblastoma is an uncommon malignant liver neoplasm occurring in infants and children and composed of... more...

MalaCards based summary: Hepatoblastoma, also known as hbl, is related to hepatitis and hepatocellular carcinoma. An important gene associated with Hepatoblastoma is APC (adenomatous polyposis coli), and among its related pathways are Canonical Wnt signaling pathway and Wnt / Hedgehog / Notch. The compounds methylazoxymethanol acetate and 1-hydroxyanthraquinone have been mentioned in the context of this disorder. Affiliated tissues include liver, fetal liver and lung, and related mouse phenotypes are no phenotypic analysis and tumorigenesis.

Aliases & Classifications for Hepatoblastoma

About this section
Sources:
10Disease Ontology, 43NIH Rare Diseases, 12DISEASES, 45Novoseek, 49Orphanet, 24GTR, 62UMLS, 57SNOMED-CT, 35MeSH, 40NCIt, 36MESH via Orphanet, 28ICD10 via Orphanet, 63UMLS via Orphanet
See all sources

Hepatoblastoma, Aliases & Descriptions:

Name: Hepatoblastoma 10 43 12 45 49 24 62
 
Hbl 10


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Liver diseases


Characteristics (Orphanet epidemiological data):

49
hepatoblastoma:
Inheritance: Not applicable; Prevalence: <1/1000000 (Europe),1-9/1000000 (Europe); Age of onset: Childhood,Infancy,Neonatal


External Ids:

Disease Ontology10 DOID:687
MeSH35 D018197
NCIt40 C3728
Orphanet49 449
SNOMED-CT57 45024009, 109843000
MESH via Orphanet36 D018197
ICD10 via Orphanet28 C22.2
UMLS via Orphanet63 C0206624

Related Diseases for Hepatoblastoma

About this section

Diseases related to Hepatoblastoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 133)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis31.0AFP, THPO, MGAT3
2hepatocellular carcinoma30.8H19, EPOR, APC, CDKN1C, CTNNB1, OTC
3beckwith-wiedemann syndrome30.8CDKN1C, H19, IGF2
4wilms tumor30.3CDKN1C, CTNNB1
5leukemia30.2CDKN1C, MPL, THPO, MGAT3, OTC, EPOR
6adenocarcinoma30.2APC, CTNNB1, AFP, CDKN1C, H19, EPOR
7adenomatous polyposis coli30.0CTNNB1, APC
8purpura30.0THPO
9pancytopenia29.9THPO, MPL
10thrombocytosis29.9EPOR, THPO, MPL
11biliary atresia29.9OTC, SLC10A1
12hypoglycemia29.8CDKN1C, SERPINA6, IGF2
13breast cancer29.8H19, CTNNB1, EPOR, IGF2
14mixed hepatoblastoma10.6
15hypobetalipoproteinemia, familial, 210.3
16neuroblastoma10.3
17hepatitis b10.3
18aicardi syndrome10.3
19simpson-golabi-behmel syndrome10.3
20macrotrabecular hepatoblastoma10.2
21peritonitis10.2
22precocious puberty10.2
23rhabdoid tumor10.2
24teratoma10.2
25gastrointestinal stromal tumor10.1
26hepatitis c virus10.1
27cystic fibrosis10.1
28hepatitis c10.1
29diarrhea10.1
30laryngitis10.1
31rhabdomyosarcoma10.1
32sarcoma10.1
33hemangioendothelioma10.1
34polyposis, juvenile intestinal10.1APC
35gallbladder cancer10.1APC
36thrombocythemia 110.1THPO
37intestinal neoplasm10.1APC, CTNNB1
38desmoid disease, hereditary10.1APC, CTNNB1
39mismatch repair cancer syndrome10.1CTNNB1, APC
40acinar cell carcinoma10.1CTNNB1, AFP
41fibromatosis10.0APC, CTNNB1
42malignant mixed mullerian tumor10.0AFP, CTNNB1
43portal vein thrombosis10.0AFP, THPO
44hepatocellular adenoma10.0AFP, CTNNB1, APC
45tubular adenocarcinoma10.0CTNNB1, AFP
46emphysema due to aat deficiency10.0OTC
47thrombocytopenia, congenital amegakaryocytic10.0MPL, THPO
48peutz-jeghers syndrome10.0APC, CTNNB1
49thrombocytopenia due to platelet alloimmunization10.0MPL, THPO
50chronic myeloproliferative disease10.0MPL, THPO

Graphical network of the top 20 diseases related to Hepatoblastoma:



Diseases related to hepatoblastoma

Symptoms for Hepatoblastoma

About this section

Drugs & Therapeutics for Hepatoblastoma

About this section

Drug clinical trials:

Search ClinicalTrials for Hepatoblastoma

Search NIH Clinical Center for Hepatoblastoma

Genetic Tests for Hepatoblastoma

About this section

Genetic tests related to Hepatoblastoma:

id Genetic test Affiliating Genes
1 Hepatoblastoma24

Anatomical Context for Hepatoblastoma

About this section

MalaCards organs/tissues related to Hepatoblastoma:

33
Liver, Fetal liver, Lung, Brain, Kidney, Heart, Thyroid, Breast, Prostate, Nk cells, Endothelial

Animal Models for Hepatoblastoma or affiliated genes

About this section

MGI Mouse Phenotypes related to Hepatoblastoma:

37 (show all 24)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.9IGF2, APC, SERPINA6, EPOR, H19, CTNNB1
2MP:00020068.9MGAT3, NQO2, AFP, APC, H19, CTNNB1
3MP:00053818.7IGF2, CYP7A1, APC, H19, CDKN1C, CTNNB1
4MP:00028738.6MGAT3, APC, EPOR, H19, CDKN1C, CTNNB1
5MP:00053808.5IGF2, APC, MPL, EPOR, H19, CDKN1C
6MP:00053678.4IGF2, APC, SERPINA6, CDKN1C, CTNNB1, OTC
7MP:00053718.4IGF2, APC, CDKN1C, CDO1, CTNNB1
8MP:00107718.3IGF2, CYP7A1, NQO2, APC, CTNNB1, OTC
9MP:00053828.2IGF2, APC, CDKN1C, CDO1, CTNNB1
10MP:00053908.1IGF2, APC, H19, CDKN1C, CDO1, CTNNB1
11MP:00053918.1IGF2, CYP7A1, APC, CDKN1C, CDO1, CTNNB1
12MP:00053857.9CTNNB1, CDO1, CDKN1C, EPOR, APC, IGF2
13MP:00053887.9IGF2, EPOR, CDKN1C, CDO1, CTNNB1
14MP:00053707.8MGAT3, IGF2, CYP7A1, APC, SERPINA6, EPOR
15MP:00036317.8IGF2, APC, EPOR, H19, CDKN1C, CTNNB1
16MP:00053797.7IGF2, AFP, APC, CDKN1C, CDO1, CTNNB1
17MP:00053897.6IGF2, AFP, APC, CDKN1C, CDO1, CTNNB1
18MP:00053977.5THPO, IGF2, NQO2, APC, MPL, EPOR
19MP:00053847.4MGAT3, IGF2, APC, MPL, EPOR, H19
20MP:00053877.2APC, NQO2, IGF2, THPO, MPL, SERPINA6
21MP:00053786.7MPL, APC, CYP7A1, IGF2, EPOR, H19
22MP:00053866.7IGF2, CYP7A1, NQO2, AFP, APC, SERPINA6
23MP:00107686.5APC, AFP, CYP7A1, IGF2, MPL, EPOR
24MP:00053765.6OTC, MGAT3, IGF2, CYP7A1, NQO2, AFP

Publications for Hepatoblastoma

About this section

Articles related to Hepatoblastoma:

(show top 50)    (show all 708)
idTitleAuthorsYear
1
Neonatal medical exposures and characteristics of low birth weight hepatoblastoma cases: a report from the Children's Oncology Group. (25044669)
2014
2
Unravelling the genetics of hepatoblastoma: Few mutations, what else? (25239079)
2014
3
Hepatoblastoma evaluated by 18F-fluoromethyl choline PET/CT. (23334143)
2013
4
Analysis of national and single-center incidence and survival after liver transplantation for hepatoblastoma: new trends and future opportunities. (23331862)
2013
5
Epigallocatechin-3-gallate inhibits hepatoblastoma growth by reactivating the Wnt inhibitor SFRP1. (24127655)
2013
6
Imaging analysis of hepatoblastoma resectability across neoadjuvant chemotherapy. (23845613)
2013
7
High mobility group AT-hook 2 is overexpressed in hepatoblastoma. (23134771)
2013
8
ER stress and ASK1-JNK activation contribute to oridonin-induced apoptosis and growth inhibition in cultured human hepatoblastoma HuH-6 cells. (23580093)
2013
9
Cytogenetics of hepatoblastoma. (22201954)
2012
10
Hepatoblastoma in an infant with paternal uniparental disomy 14. (23181499)
2012
11
Prognostic implications of serum alpha-fetoprotein response during treatment of hepatoblastoma. (21370433)
2011
12
Initial liver transplantation for unresectable hepatoblastoma after chemotherapy. (21910210)
2011
13
Hepatoblastoma with tumor extension through the inferior vena cava into the right atrium. (20479678)
2010
14
Sterol-regulatory-element-binding protein 2 and nuclear factor Y control human farnesyl diphosphate synthase expression and affect cell proliferation in hepatoblastoma cells. (20450493)
2010
15
Hepatoblastoma in association with bilateral polycystic kidneys. (21034924)
2010
16
Altered microRNA Expression Patterns in Hepatoblastoma Patients. (19701500)
2009
17
Overexpression of Dickkopf 3 in hepatoblastomas and hepatocellular carcinomas. (19437037)
2009
18
Arachidonic Acid Activates K-Cl-cotransport in HepG2 Human Hepatoblastoma Cells. (19915704)
2009
19
Treatment-related acute myelomonocytic leukemia with t(11;19) in a child following chemotherapy for hepatoblastoma. (17973320)
2008
20
Hepatoblastoma in a Noonan syndrome patient with a PTPN11 mutation. (18253957)
2008
21
Teratoid hepatoblastoma. (19065325)
2008
22
In vitro and in vivo evaluation of photodynamic techniques for the experimental treatment of human hepatoblastoma and neuroblastoma: preliminary results. (19009300)
2008
23
Evaluation and treatment of hepatoblastoma. (16423617)
2006
24
Hepatoblastoma: why so many low-birth-weight infants? (16456653)
2006
25
Chromosome 7 aberrations in a young girl with myelodysplasia and hepatoblastoma: an unusual association. (16317299)
2006
26
Second case of hepatoblastoma in a young patient with Simpson-Golabi-Behmel syndrome. (16166055)
2005
27
Liver transplantation for hepatoblastoma: results from the International Society of Pediatric Oncology (SIOP) study SIOPEL-1 and review of the world experience. (14752798)
2004
28
Hepatoblastoma and hepatocellular carcinoma in children. (15146904)
2004
29
Curative resection by superior hepatectomy for advanced hepatoblastoma facilitated by the presence of a large inferior right hepatic vein. (18333062)
2004
30
Brain metastases in hepatoblastoma. (15087112)
2004
31
Tamoxifen cytotoxicity in hepatoblastoma cells stably transfected with human CYP3A4. (15006542)
2004
32
Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas. (15221005)
2004
33
Improved survival outcome for hepatoblastoma based on an optimal chemotherapeutic regimen--a report from the study group for pediatric solid malignant tumors in the Kyushu area. (14966739)
2004
34
Hepatoblastoma in a girl with biliary atresia: coincidence or co-incidence. (15382280)
2004
35
Analysis of treatment outcome for children with recurrent or metastatic hepatoblastoma. (12768314)
2003
36
Orthotopic liver transplantation for unresectable hepatoblastoma. (12352881)
2002
37
Hepatoblastoma: assessment of criteria for histologic classification. (12228903)
2002
38
Beta-catenin mutations and protein accumulation in all hepatoblastomas examined from B6C3F1 mice treated with anthraquinone or oxazepam. (10850429)
2000
39
Role of Ca2+ influx in the tert-butyl hydroperoxide-induced apoptosis of HepG2 human hepatoblastoma cells. (9873835)
1998
40
Thrombopoietin in patients with hepatoblastoma. (9766812)
1998
41
Hepatoblastoma and APC gene mutation in familial adenomatous polyposis. (9378405)
1997
42
Timing and magnitude of decline in alpha-fetoprotein levels in treated children with unresectable or metastatic hepatoblastoma are predictors of outcome: a report from the Children's Cancer Group. (9060563)
1997
43
Hepatoblastoma and APC gene mutation in familial adenomatous polyposis. (9038672)
1996
44
Differential effects of insulin and insulin-like growth factor I on the production of plasma steroid-binding globulins by human hepatoblastoma-derived (Hep G2) cells. (7536204)
1995
45
Establishment and characterization of a novel hepatoblastoma-derived cell line. (7595832)
1995
46
Identification of a human immunodeficiency virus type 1 TAR binding protein in human hepatoblastoma HepG2 cells that trans-activates HIV-1 LTR-directed gene expression. (8286041)
1994
47
Production of interleukin-1 beta and interleukin-6 in hepatoblastoma. (8383628)
1993
48
Combined cystic teratoma and hepatoblastoma of the liver. Probable divergent differentiation of an uncommitted hepatic precursor cell. (8221556)
1993
49
Epithelial and mixed hepatoblastoma in the adult. Histological observations and general considerations. (1317555)
1992
50
Hepatoblastoma, pigmented ocular fundus lesions and jaw lesions in Gardner syndrome. (3354603)
1988

Variations for Hepatoblastoma

About this section

Expression for genes affiliated with Hepatoblastoma

About this section

Search GEO for disease gene expression data for Hepatoblastoma.

Pathways for genes affiliated with Hepatoblastoma

About this section

Compounds for genes affiliated with Hepatoblastoma

About this section

Compounds related to Hepatoblastoma according to GeneCards/GeneDecks:

(show top 50)    (show all 97)
idCompoundScoreTop Affiliating Genes
1methylazoxymethanol acetate4510.4APC, CTNNB1
21-hydroxyanthraquinone4510.4APC, CTNNB1
3samp4510.3APC, CTNNB1
4megapoietin4510.2THPO, MPL
51,2-dimethylhydrazine4510.2APC, CTNNB1
6nap-24510.0IGF2, H19
7sodium bisulfite459.9CTNNB1, APC, IGF2
8thromboxane45 2610.7THPO, CYP7A1, MPL
9aspirin45 51 30 2612.7CTNNB1, MPL, APC, THPO
10methylcellulose459.5CTNNB1, EPOR, IGF2, THPO
11tgf beta1459.5THPO, IGF2, AFP, CTNNB1
12polyethylene glycol459.5MPL, AFP, IGF2, THPO
13rsai459.5IGF2, H19, OTC
14prostacyclin459.4APC, CYP7A1, IGF2, THPO
15triiodothyronine459.3SERPINA6, CYP7A1, IGF2
16vitamin d459.3IGF2, AFP, APC, CTNNB1
17tamoxifen45 51 30 1312.2THPO, IGF2, SERPINA6, CTNNB1
18polysaccharide459.2CTNNB1, AFP, THPO, MGAT3
19fatty acid459.2AFP, APC, SERPINA6, CTNNB1, OTC
20indomethacin45 30 61 1312.2SLC10A1, APC, IGF2, THPO
21acth459.2IGF2, APC, SERPINA6, H19, CDKN1C
22paraffin459.2IGF2, AFP, APC, EPOR, H19, CTNNB1
23paclitaxel45 51 1311.1CTNNB1, AFP, IGF2, THPO
24thymidine45 2610.0THPO, IGF2, AFP, EPOR, H19, CTNNB1
25glycogen45 2610.0IGF2, AFP, APC, CTNNB1, OTC
26chloramphenicol45 3 51 1312.0OTC, AFP, CYP7A1, IGF2
27glutamine459.0IGF2, AFP, APC, CTNNB1, OTC
28testosterone45 61 26 1312.0IGF2, AFP, APC, SERPINA6, CTNNB1, SLC10A1
29sodium45 2610.0THPO, AFP, APC, SLC10A1, OTC
30phosphatidylinositol459.0THPO, IGF2, APC, MPL, EPOR, CTNNB1
31vegf459.0THPO, IGF2, AFP, MPL, EPOR, CTNNB1
32butyrate458.9THPO, IGF2, AFP, CTNNB1, OTC
33dexamethasone45 51 30 1311.9THPO, IGF2, CYP7A1, AFP, SERPINA6, CTNNB1
345-aza-2deoxycytidine458.9THPO, IGF2, APC, H19, CDKN1C, CTNNB1
35cholesterol45 30 26 1311.9SLC10A1, CDKN1C, SERPINA6, AFP, CYP7A1
36iron45 269.8CDO1, EPOR, MPL, AFP, THPO
37agar458.8CTNNB1, THPO, IGF2, AFP, MPL, EPOR
38alanine458.7THPO, IGF2, AFP, MPL, SERPINA6, EPOR
39serine458.7IGF2, AFP, APC, MPL, SERPINA6, EPOR
405fluorouracil458.7THPO, IGF2, AFP, MPL, CTNNB1, OTC
41progesterone45 30 61 26 1312.7IGF2, CYP7A1, AFP, APC, SERPINA6, CTNNB1
42estrogen458.5THPO, IGF2, CYP7A1, AFP, APC, SERPINA6
43steroid458.5THPO, IGF2, CYP7A1, AFP, SERPINA6, EPOR
44oxygen45 269.4THPO, CYP7A1, NQO2, AFP, EPOR, CDO1
45retinoic acid45 269.3MGAT3, THPO, IGF2, CYP7A1, AFP, APC
46lipid458.2CYP7A1, AFP, APC, SERPINA6, EPOR, OTC
47tyrosine458.2THPO, IGF2, CYP7A1, AFP, APC, MPL
48cysteine458.1THPO, IGF2, MPL, SERPINA6, EPOR, CDO1
49glucose458.1THPO, IGF2, CYP7A1, AFP, APC, SERPINA6
50oligonucleotide457.7THPO, IGF2, AFP, APC, EPOR, CDO1

GO Terms for genes affiliated with Hepatoblastoma

About this section

Cellular components related to Hepatoblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell-cell adherens junctionGO:000591310.0CTNNB1, APC
2beta-catenin destruction complexGO:00308779.7CTNNB1, APC

Biological processes related to Hepatoblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1canonical Wnt signaling pathway involved in negative regulation of apoptotic processGO:004433610.1CTNNB1, APC
2T cell differentiation in thymusGO:003307710.0CTNNB1, APC
3proximal/distal pattern formationGO:00099549.9APC, CTNNB1
4midgut developmentGO:00074949.6OTC, CTNNB1
5platelet activationGO:00301689.0MPL, IGF2, THPO

Molecular functions related to Hepatoblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cadherin bindingGO:004529610.0CTNNB1, APC

Products for genes affiliated with Hepatoblastoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Hepatoblastoma

About this section
4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet