HBL
MCID: HPT022
MIFTS: 65

Hepatoblastoma (HBL) malady

Liver diseases, Cancer diseases categories

Summaries for Hepatoblastoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 Hepatoblastoma is an uncommon malignant liver neoplasm occurring in infants and children and composed of... more...

MalaCards: Hepatoblastoma, also known as HBL, is related to hepatocellular carcinoma and hepatitis. An important gene associated with Hepatoblastoma is AXIN1 (axin 1), and among its related pathways are Wnt / Hedgehog / Notch and Rho Family GTPases. The compounds oligonucleotide and progesterone have been mentioned in the context of this disorder. Affiliated tissues include liver, fetal liver and lung, and related mouse phenotypes are homeostasis/metabolism and mortality/aging.

Aliases & Classifications for Hepatoblastoma

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 22GTR, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 35MESH via Orphanet, 26ICD10 via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Liver diseases


Characteristics (Orphanet epidemiological data):

48
hepatoblastoma:
Inheritance: Sporadic; Age of onset: Childhood


Aliases & Descriptions:

hepatoblastoma 8 42 22 10 44 48 60
hbl 8


External Ids:

Disease Ontology8 DOID:687
NCIt39 C3728
MeSH34 D018197
SNOMED-CT via Orphanet57 45024009, 109843000
SNOMED-CT56 109843000, 45024009
UMLS via Orphanet61 C0206624
MESH via Orphanet35 D018197
ICD10 via Orphanet26 C22.2

Related Diseases for Hepatoblastoma

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Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Hepatoblastoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 124)
idRelated DiseaseScoreTop Affiliating Genes
1hepatocellular carcinoma30.8H19, APC, CTNNB1, MGAT3, AFP, IGF2
2hepatitis30.8MGAT3, AFP, THPO
3beckwith-wiedemann syndrome30.7H19, IGF2, CDKN1C, SLC22A18
4familial adenomatous polyposis30.6AXIN2, AXIN1, DKK1, CTNNB1, APC
5hepatitis b30.4MGAT3, AFP
6leukemia30.2H19, MGAT3, MPL, CDKN1C, EPOR, PLAG1
7adenocarcinoma30.1H19, APC, CTNNB1, AFP, CDKN1C, AXIN1
8acute leukemia30.0THPO, EPOR, MPL
9breast cancer29.8H19, APC, CTNNB1, IGF2, DKK1, CDKN1C
10hemihypertrophy29.8H19, IGF2, CDKN1C
11sarcoma29.8THPO, IGF2
12rhabdomyosarcoma29.8SLC22A18, IGF2, H19
13hypoglycemia29.8SERPINA6, CDKN1C, IGF2
14biliary atresia29.8SLC10A1, OTC
15pancytopenia29.8MPL, THPO
16thrombocytosis29.8THPO, EPOR, MPL
17meningioma29.8IGF2
18mixed hepatoblastoma10.5
19hepatitis a10.4
20hypobetalipoproteinemia, familial, 210.3
21neuroblastoma10.2
22macrotrabecular hepatoblastoma10.1
23aicardi syndrome10.1
24liver disease10.1
25peritonitis10.1
26cystic fibrosis10.0
27hepatitis c10.0
28gastrointestinal stromal tumor10.0
29diarrhea10.0
30laryngitis10.0
31simpson-golabi-behmel syndrome type 110.0
32hepatocellular carcinoma, somatic10.0
33hepatoblastoma, somatic10.0
34colorectal cancer10.0H19, APC, CTNNB1, IGF2, DKK1, CDKN1C
35adenoma10.0H19, APC, CTNNB1, IGF2, CDKN1C, AXIN2
36prostate cancer10.0APC, CTNNB1, IGF2, DKK1, AXIN1, EPOR
37stomach cancer10.0H19, APC, CTNNB1, AFP, CDKN1C, EPOR
38wilms tumor10.0H19, CTNNB1, IGF2, CDKN1C, SLC22A18
39choriocarcinoma10.0H19, AFP, IGF2, CDKN1C, EPOR
40squamous cell carcinoma10.0H19, APC, CTNNB1, CDKN1C, AXIN1, EPOR
41chronic myeloid leukemia10.0H19, MPL, CDKN1C, EPOR, THPO
42ovarian cancer10.0IGF2, AFP, CTNNB1, H19
43colon cancer10.0APC, CTNNB1, IGF2, AXIN2, EPOR
44liver cirrhosis10.0MGAT3, MPL, AFP, THPO
45myeloproliferative disorder10.0THPO, EPOR, MPL, H19
46gastric adenocarcinoma10.0APC, CTNNB1, AFP, EPOR
47endometrial carcinoma10.0APC, CTNNB1, IGF2, SERPINA6
48hepatocellular adenoma10.0APC, CTNNB1, AFP
49pancreatic cancer10.0CDKN1C, DKK1, CTNNB1
50refractory anemia10.0THPO, EPOR, MPL

Graphical network of the top 20 diseases related to Hepatoblastoma:



Diseases related to hepatoblastoma

Clinical Features for Hepatoblastoma

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Drugs & Therapeutics for Hepatoblastoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Hepatoblastoma

Drug clinical trials:

Search ClinicalTrials for Hepatoblastoma

Search NIH Clinical Center for Hepatoblastoma

Search CenterWatch for Hepatoblastoma

Genetic Tests for Hepatoblastoma

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Sources:
22GTR
See all sources

Genetic tests related to Hepatoblastoma:

id Genetic test Affiliating Genes
1 Hepatoblastoma22

Anatomical Context for Hepatoblastoma

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32MalaCards
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MalaCards organs/tissues related to Hepatoblastoma:

32
Liver, Fetal liver, Lung, Brain, Kidney, Heart, Breast, Endothelial, Prostate, Nk cells, Thyroid

Animal Models for Hepatoblastoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Hepatoblastoma:

36 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537611.8MPL, MGAT3, CTNNB1, APC, H19, AFP
2MP:001076811.7H19, APC, CTNNB1, MPL, AFP, IGF2
3MP:000538011.7H19, APC, CTNNB1, MPL, IGF2, DKK1
4MP:000538411.5H19, APC, CTNNB1, MGAT3, MPL, IGF2
5MP:000538211.5H19, APC, CTNNB1, IGF2, DKK1, CDKN1C
6MP:000536711.5H19, APC, CTNNB1, IGF2, DKK1, CDKN1C
7MP:000538511.4H19, APC, CTNNB1, IGF2, CDKN1C, CDO1
8MP:000537011.3H19, APC, CTNNB1, MGAT3, IGF2, EPOR
9MP:000537911.3H19, AFP, CDKN1C, CDO1, AXIN2, PLAG1
10MP:000537811.3H19, APC, CTNNB1, MPL, IGF2, CDKN1C
11MP:000538911.3APC, CTNNB1, AFP, CDKN1C, CDO1, PLAG1
12MP:000539011.3H19, APC, DKK1, CDKN1C, CDO1, AXIN1
13MP:000287311.2H19, APC, CTNNB1, MGAT3, CDKN1C, AXIN1
14MP:000539111.2H19, APC, DKK1, CDO1, AXIN2, PLAG1
15MP:000538611.2APC, CTNNB1, AFP, IGF2, CDKN1C, CDO1
16MP:000537111.1AXIN2, CDO1, DKK1, H19
17MP:000538711.1APC, CTNNB1, MPL, IGF2, CDKN1C, EPOR
18MP:000538811.0CTNNB1, IGF2, DKK1, CDO1, AXIN1, EPOR
19MP:000363111.0APC, DKK1, AXIN1, AXIN2, OTC
20MP:000301210.9APC, CTNNB1, IGF2, EPOR, SERPINA6, H19
21MP:000539710.8APC, CTNNB1, MPL, IGF2, CDKN1C, EPOR

Publications for Hepatoblastoma

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Sources:
50PubMed
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Articles related to Hepatoblastoma:

(show top 50)    (show all 666)
idTitleAuthorsYear
1
ER stress and ASK1-JNK activation contribute to oridonin-induced apoptosis and growth inhibition in cultured human hepatoblastoma HuH-6 cells. (23580093)
2013
2
FAK Inhibition Decreases Hepatoblastoma Survival Both In Vitro and In Vivo. (23544173)
2013
3
Extramedullary hematopoiesis as a 'clue' to diagnosis of hepatoblastoma on fine needle aspiration cytology: A report of two cases. (24130414)
2013
4
Increased expression of survivin in hepatoblastoma after chemotherapy. (23444076)
2013
5
Effect of sorafenib combined with cytostatic agents on hepatoblastoma cell lines and xenografts. (23257893)
2013
6
Maternal pregnancy events and exposures and risk of hepatoblastoma: a Children's Oncology Group (COG) study. (23312454)
2013
7
Outcomes of hepatoblastoma in the Indian context. (22080621)
2012
8
Genetics and epigenetics of hepatoblastoma. (22807084)
2012
9
Docetaxel in the treatment of children with refractory or relapsed hepatoblastoma. (22469940)
2012
10
Treatment effects of the multikinase inhibitor sorafenib on hepatoblastoma cell lines and xenografts in NMRI-Foxn1 nu mice. (22176637)
2012
11
CD155 is involved in NK-cell mediated lysis of human hepatoblastoma in vitro. (21622149)
2011
12
Acute tumor lysis syndrome in a 7-month-old with hepatoblastoma. (19926992)
2010
13
Hepatoblastoma. Clinical experience at a single institution using the Siopel staging system. (20308725)
2010
14
Survival trends in children with hepatoblastoma. (19308432)
2009
15
Gene expression profiling reveals signatures characterizing histologic subtypes of hepatoblastoma and global deregulation in cell growth and survival pathways. (19200578)
2009
16
Treatment-related acute myelomonocytic leukemia with t(11;19) in a child following chemotherapy for hepatoblastoma. (17973320)
2008
17
Drug resistance in hepatoblastoma. (17430157)
2007
18
Reciprocal expression of CCAAT/enhancer binding proteins alpha and beta in hepatoblastomas and its prognostic significance. (17203171)
2007
19
Claudin-1 and claudin-2 differentiate fetal and embryonal components in human hepatoblastoma. (16647953)
2006
20
Hepatoblastoma: an oncological review. (16404556)
2006
21
Nuclear accumulations of p53 and Mdm2 are accompanied by reductions in c-Abl and p300 in zinc-depleted human hepatoblastoma cells. (16636310)
2006
22
Videoscopic fluorescence diagnosis of peritoneal and thoracic metastases from human hepatoblastoma in nude rats. (16206006)
2005
23
Fine needle aspiration cytology of hepatoblastoma. Recognition of subtypes on cytomorphology. (16124162)
2005
24
Relationships between perinatal and maternal characteristics and hepatoblastoma: a report from the UKCCS. (15763651)
2005
25
Membranes for biohybrid liver support: the behaviour of C3A hepatoblastoma cells is dependent on the composition of acrylonitrile copolymers. (15796302)
2005
26
Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas. (15221005)
2004
27
Hepatoblastoma--evolution of management and outcome and significance of histology of the resected tumor. A 31-year experience with 40 cases. (15359384)
2004
28
CCND1 polymorphism and age of onset of hepatoblastoma. (15133490)
2004
29
Outcome and complications after resection of hepatoblastoma. (14966740)
2004
30
Hypermethylation associated with inactivation of the SOCS-1 gene, a JAK/STAT inhibitor, in human hepatoblastomas. (12601549)
2003
31
Comparative genomic hybridization analysis of hepatoblastoma reveals high frequency of X-chromosome gains and similarities between epithelial and stromal components. (14562281)
2003
32
Hepatoblastoma: assessment of criteria for histologic classification. (12228903)
2002
33
Distinct patterns of p27/KIP 1 gene expression in hepatoblastoma and prognostic implications with correlation before and after chemotherapy. (11957145)
2002
34
Novel therapeutic approaches in the treatment of children with hepatoblastoma. (12468918)
2002
35
Acute lymphoblastic leukemia and hepatoblastoma in a family. (12217198)
2002
36
Cetaben-induced changes on the morphology and peroxisomal enzymes in MH1C1 rat hepatoma cells and HepG2 human hepatoblastoma cells. (11455451)
2001
37
Stable expression and functional characterization of a Na+-taurocholate cotransporting green fluorescent protein in human hepatoblastoma HepG2 cells. (19003375)
2000
38
Undifferentiated small-cell hepatoblastoma]. (11148826)
2000
39
Effects of Bcl-2 and Bcl-XL protein levels on chemoresistance of hepatoblastoma HepG2 cell line. (10874473)
2000
40
Role of Ca2+ influx in the tert-butyl hydroperoxide-induced apoptosis of HepG2 human hepatoblastoma cells. (9873835)
1998
41
Expression of transforming growth factor-alpha in hepatoblastoma. (9708932)
1998
42
The occurrence of liver growth factor in hepatoblastoma. (9676393)
1998
43
Overexpression of cyclin D1 and cdk4 in tumorigenesis of sporadic hepatoblastomas. (9851251)
1998
44
Corticosteroid-binding globulin synthesis regulation by cytokines and glucocorticoids in human hepatoblastoma-derived (HepG2) cells. (9360537)
1997
45
Differential effects of insulin and insulin-like growth factor I on the production of plasma steroid-binding globulins by human hepatoblastoma-derived (Hep G2) cells. (7536204)
1995
46
Hepatic lipase secretion in human hepatoblastoma cell line Hep G2 is not related to cellular cholesterol homeostasis. (8750779)
1995
47
A case study of Beckwith-Wiedemann syndrome associated with hepatoblastoma. (8392453)
1993
48
The 11p15.5 ribonucleotide reductase M1 subunit locus is not imprinted in Wilms' tumour and hepatoblastoma. (8386696)
1993
49
Opsoclonus-myoclonus with Beckwith-Wiedemann syndrome and hepatoblastoma. (1313677)
1992
50
Acute polyhydramnios associated with fetal hepatoblastoma. (2993051)
1985

Genetic Variations for Hepatoblastoma

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Expression for genes affiliated with Hepatoblastoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Hepatoblastoma

Search GEO for disease gene expression data for Hepatoblastoma.

Pathways for genes affiliated with Hepatoblastoma

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Sources:
4Cell Signaling Technology, 51QIAGEN, 29KEGG, 52R&D Systems, 37NCBI BioSystems Database, 59Tocris Bioscience, 12EMD Millipore, 53Reactome
See all sources

Pathways related to Hepatoblastoma according to GeneCards/GeneDecks:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.9AXIN2, AXIN1, DKK1, AFP, CTNNB1, APC
2
Hide members
10.9APC, CTNNB1, IGF2, AXIN1, EPOR, THPO
3
Hide members
10.9APC, CTNNB1, IGF2, AXIN1, EPOR, THPO
410.9AXIN2, AXIN1, AFP, CTNNB1, APC
5
Hide members
10.9APC, CTNNB1, DKK1, AXIN1, AXIN2
610.8AXIN2, AXIN1, CTNNB1, APC
7
Hide members
10.8APC, CTNNB1, AXIN1, AXIN2
8
Hide members
10.8APC, CTNNB1, AXIN1, AXIN2
9
Hide members
10.8APC, CTNNB1, AXIN1, AXIN2
1010.8APC, CTNNB1, AXIN1, AXIN2
1110.8AXIN1, IGF2, CTNNB1, APC
12
Hide members
10.8AXIN1, DKK1, CTNNB1, APC
1310.8APC, CTNNB1, DKK1, AXIN1
1410.8APC, CTNNB1, DKK1, AXIN1
1510.8APC, CTNNB1, DKK1, AXIN1
1610.8APC, CTNNB1, DKK1, AXIN2
17
Hide members
10.7AXIN1, CTNNB1, APC
18
Cytoskeleton remodeling Reverse signaling by ephrin B
Hide members
10.7AXIN2, AXIN1, CTNNB1
1910.7CTNNB1, AXIN1, AXIN2
20
Hide members
10.7MGAT3, IGF2, AXIN1

Compounds for genes affiliated with Hepatoblastoma

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Sources:
44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB
See all sources

Compounds related to Hepatoblastoma according to GeneCards/GeneDecks:

(show top 50)    (show all 61)
idCompoundScoreTop Affiliating Genes
1oligonucleotide4411.6APC, CTNNB1, AFP, IGF2, CDO1, EPOR
2progesterone44 59 28 11 2415.5APC, CTNNB1, UGT2B4, AFP, IGF2, DKK1
3steroid4411.5H19, CTNNB1, UGT2B4, AFP, IGF2, EPOR
4retinoic acid44 2412.5H19, APC, CTNNB1, MGAT3, UGT2B4, AFP
5agar4411.5THPO, H19, CTNNB1, MPL, AFP, IGF2
6glycogen44 2412.5APC, CTNNB1, AFP, IGF2, DKK1, AXIN2
7testosterone44 59 11 2414.4APC, CTNNB1, UGT2B4, AFP, IGF2, SLC10A1
8alanine4411.4CTNNB1, MPL, AFP, IGF2, EPOR, THPO
9serine4411.4APC, CTNNB1, MPL, AFP, IGF2, AXIN2
105-aza-2deoxycytidine4411.4H19, APC, CTNNB1, IGF2, CDKN1C, THPO
115fluorouracil4411.4CTNNB1, MPL, AFP, IGF2, THPO, OTC
12cysteine4411.4CTNNB1, MPL, IGF2, CDO1, EPOR, THPO
13paraffin4411.4H19, APC, CTNNB1, AFP, IGF2, EPOR
14thymidine44 2412.3H19, CTNNB1, AFP, IGF2, EPOR, THPO
15tyrosine4411.3H19, APC, CTNNB1, MPL, AFP, IGF2
16acth4411.3H19, APC, IGF2, CDKN1C, SERPINA6
17tamoxifen44 49 28 1114.2CTNNB1, UGT2B4, IGF2, THPO, SERPINA6
18vegf4411.2CTNNB1, MPL, AFP, IGF2, EPOR, THPO
19methylcellulose4411.2CTNNB1, IGF2, EPOR, THPO
20phosphatidylinositol4411.2APC, CTNNB1, MPL, IGF2, EPOR, THPO
21polyethylene glycol4411.2MPL, AFP, IGF2, THPO
22estrone44 28 11 2414.2UGT2B4, AFP, IGF2, SERPINA6
23glutamine4411.2APC, CTNNB1, AFP, IGF2, OTC
24threonine4411.2APC, CTNNB1, MPL, AFP, AXIN2, OTC
25iron44 2412.2MPL, AFP, CDO1, EPOR, THPO
26samp4411.2APC, CTNNB1, AXIN2
27glucose4411.1APC, IGF2, OTC, SERPINA6
28sodium bisulfite4411.1IGF2, CTNNB1, APC
29tgf beta14411.1THPO, IGF2, AFP, CTNNB1
30rsai4411.1OTC, IGF2, H19
31fatty acid4411.1APC, CTNNB1, OTC, SERPINA6
32sodium44 2412.0APC, AFP, THPO, SLC10A1, OTC
33butyrate4411.0OTC, THPO
34methylazoxymethanol acetate4411.0APC, CTNNB1
351-hydroxyanthraquinone4411.0APC, CTNNB1
36pidotimod4411.0CTNNB1, AXIN2
37megapoietin4411.0MPL, THPO
38sialic acid4411.0PLAG1, THPO
39aspirin44 49 28 2414.0THPO, MPL, CTNNB1, APC
40estrogen4411.0THPO
41dihydrotestosterone44 28 11 2414.0SERPINA6, UGT2B4
42nap-24411.0H19, IGF2
431,2-dimethylhydrazine4410.9APC, CTNNB1
44apai4410.8IGF2, H19
45azoxymethane4410.7APC, CTNNB1
46lithium44 49 11 2413.7DKK1, CTNNB1, APC
47acth 1-244410.7IGF2, SERPINA6
482-amino-3-methylimidazo(4,5-f)quinoline4410.6CTNNB1, APC
49anagrelide44 1111.5MPL, THPO
50indomethacin44 59 28 1113.5SLC10A1, THPO, IGF2, APC

GO Terms for genes affiliated with Hepatoblastoma

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Sources:
16Gene Ontology
See all sources

Cellular components related to Hepatoblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1beta-catenin destruction complexGO:03087710.8AXIN2, AXIN1, CTNNB1, APC
2cell cortexGO:00593810.7AXIN2, AXIN1, CTNNB1
3lateral plasma membraneGO:01632810.6APC, CTNNB1, AXIN1
4cytoplasmic microtubuleGO:00588110.4AXIN2, AXIN1, APC

Biological processes related to Hepatoblastoma according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of canonical Wnt receptor signaling pathwayGO:09009010.9AXIN2, AXIN1, DKK1, APC
2Wnt receptor signaling pathway involved in somitogenesisGO:09024410.9AXIN2, AXIN1, DKK1
3dorsal/ventral axis specificationGO:00995010.9CTNNB1, AXIN1, AXIN2
4regulation of centromeric sister chromatid cohesionGO:07060210.7CTNNB1, AXIN2
5cytoplasmic microtubule organizationGO:03112210.6AXIN1, APC
6midgut developmentGO:00749410.6OTC, CTNNB1
7canonical Wnt receptor signaling pathwayGO:06007010.6APC, CTNNB1, AXIN1
8positive regulation of protein phosphorylationGO:00193410.4AXIN2, AXIN1, IGF2

Molecular functions related to Hepatoblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein kinase bindingGO:01990110.8AXIN2, AXIN1, CTNNB1, APC
2I-SMAD bindingGO:07041110.8AXIN2, AXIN1, CTNNB1
3beta-catenin bindingGO:00801310.7AXIN2, AXIN1, APC
4signal transducer activityGO:00487110.7CTNNB1, DKK1, AXIN1, AXIN2
5armadillo repeat domain bindingGO:07001610.3AXIN2, AXIN1

Products for genes affiliated with Hepatoblastoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hepatoblastoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet