HBL
MCID: HPT022
MIFTS: 62

Hepatoblastoma (HBL) malady

Rare diseases, Liver diseases, Cancer diseases categories
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Summaries for Hepatoblastoma

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Wikipedia:65 Hepatoblastoma is an uncommon malignant liver neoplasm occurring in infants and children and composed of... more...

MalaCards based summary: Hepatoblastoma, also known as HBL, is related to hepatitis and beckwith-wiedemann syndrome. An important gene associated with Hepatoblastoma is APC (adenomatous polyposis coli), and among its related pathways are Canonical Wnt signaling pathway and Wnt / Hedgehog / Notch. The compounds 1-hydroxyanthraquinone and methylazoxymethanol acetate have been mentioned in the context of this disorder. Affiliated tissues include liver, fetal liver and lung, and related mouse phenotypes are no phenotypic analysis and tumorigenesis.

Aliases & Classifications for Hepatoblastoma

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 22GTR, 10DISEASES, 44Novoseek, 48Orphanet, 62UMLS, 34MeSH, 57SNOMED-CT, 39NCIt, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet
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Hepatoblastoma, Aliases & Descriptions:

Name: Hepatoblastoma 8 42 22 10 44 48 62
 
Hbl 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Liver diseases


Characteristics (Orphanet epidemiological data):

48
hepatoblastoma:
Inheritance: Sporadic; Age of onset: Childhood


External Ids:

Disease Ontology8 DOID:687
MeSH34 D018197
NCIt39 C3728
SNOMED-CT57 109843000, 45024009
MESH via Orphanet35 D018197
ICD10 via Orphanet26 C22.2
UMLS via Orphanet63 C0206624

Related Diseases for Hepatoblastoma

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Diseases related to Hepatoblastoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 146)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis31.3MGAT3, THPO, AFP
2beckwith-wiedemann syndrome30.6IGF2, H19, CDKN1C
3gardner syndrome30.6APC, CTNNB1
4purpura30.6THPO
5erythrocytosis30.3MPL, EPOR
6pancytopenia30.3THPO, MPL
7hemihypertrophy30.2CDKN1C, H19, IGF2
8thrombocytosis30.2EPOR, MPL, THPO
9biliary atresia30.1OTC, SLC10A1
10adenocarcinoma30.0AFP, APC, EPOR, H19, CDKN1C, CTNNB1
11wilms tumor30.0IGF2, H19, CDKN1C, CTNNB1
12acute lymphoblastic leukemia29.8THPO, MPL, EPOR, CDKN1C
13hypoglycemia29.7CDKN1C, SERPINA6, IGF2
14breast cancer29.6IGF2, EPOR, H19, CTNNB1
15leukemia29.6MGAT3, THPO, MPL, EPOR, H19, CDKN1C
16hepatocellular carcinoma10.6
17mixed hepatoblastoma10.6
18juvenile polyposis syndrome10.6APC
19gallbladder cancer10.5APC
20thrombocythemia 110.5THPO
21intestinal neoplasm10.5APC, CTNNB1
22desmoid tumor10.5CTNNB1, APC
23turcot syndrome10.5APC, CTNNB1
24acinar cell carcinoma10.4AFP, CTNNB1
25colorectal cancer, somatic10.4APC, CTNNB1
26familial adenomatous polyposis10.4
27fibromatosis10.4APC, CTNNB1
28malignant mixed mullerian tumor10.4AFP, CTNNB1
29portal vein thrombosis10.4AFP, THPO
30hepatocellular adenoma10.4CTNNB1, APC, AFP
31emphysema due to aat deficiency10.4OTC
32tubular adenocarcinoma10.4AFP, CTNNB1
33congenital amegakaryocytic thrombocytopenia10.4THPO, MPL
34peutz-jeghers syndrome10.4APC, CTNNB1
35thrombocytopenia due to platelet alloimmunization10.4THPO, MPL
36bone marrow cancer10.3THPO, MPL
37megakaryocytic leukemia10.3EPOR, THPO
38hypobetalipoproteinemia, familial, 210.3
39autoimmune thrombocytopenic purpura10.3THPO, MPL
40hepatitis b10.3
41neuroblastoma10.3
42hemorrhagic thrombocythemia10.3THPO, MPL
43splenomegaly10.3THPO, MPL
44gestational trophoblastic tumor10.3CDKN1C, H19
45acute liver failure10.2THPO, OTC
46gastric adenocarcinoma10.2AFP, APC, EPOR, CTNNB1
47refractory anemia10.2THPO, MPL, EPOR
48polycythemia10.2THPO, MPL, EPOR
49polycythemia vera10.2THPO, MPL, EPOR
50neutropenia10.2EPOR, MPL, THPO

Graphical network of the top 20 diseases related to Hepatoblastoma:



Diseases related to hepatoblastoma

Symptoms for Hepatoblastoma

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Drugs & Therapeutics for Hepatoblastoma

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Drug clinical trials:

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Search NIH Clinical Center for Hepatoblastoma

Genetic Tests for Hepatoblastoma

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Genetic tests related to Hepatoblastoma:

id Genetic test Affiliating Genes
1 Hepatoblastoma22

Anatomical Context for Hepatoblastoma

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MalaCards organs/tissues related to Hepatoblastoma:

32
Liver, Fetal liver, Lung, Brain, Kidney, Heart, Thyroid, Breast, Prostate, Nk cells, Endothelial

Animal Models for Hepatoblastoma or affiliated genes

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MGI Mouse Phenotypes related to Hepatoblastoma:

36 (show all 24)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.9IGF2, APC, SERPINA6, EPOR, H19, CTNNB1
2MP:00020068.9MGAT3, NQO2, AFP, APC, H19, CTNNB1
3MP:00053818.7IGF2, CYP7A1, APC, H19, CDKN1C, CTNNB1
4MP:00028738.6MGAT3, APC, EPOR, H19, CDKN1C, CTNNB1
5MP:00053808.5IGF2, APC, MPL, EPOR, H19, CDKN1C
6MP:00053678.4IGF2, APC, SERPINA6, CDKN1C, CTNNB1, OTC
7MP:00053718.4IGF2, APC, CDKN1C, CDO1, CTNNB1
8MP:00107718.3IGF2, CYP7A1, NQO2, APC, CTNNB1, OTC
9MP:00053828.2IGF2, APC, CDKN1C, CDO1, CTNNB1
10MP:00053908.1IGF2, APC, H19, CDKN1C, CDO1, CTNNB1
11MP:00053918.1IGF2, CYP7A1, APC, CDKN1C, CDO1, CTNNB1
12MP:00053857.9CTNNB1, CDO1, CDKN1C, EPOR, APC, IGF2
13MP:00053887.9IGF2, EPOR, CDKN1C, CDO1, CTNNB1
14MP:00053707.8MGAT3, IGF2, CYP7A1, APC, SERPINA6, EPOR
15MP:00036317.8IGF2, APC, EPOR, H19, CDKN1C, CTNNB1
16MP:00053797.7IGF2, AFP, APC, CDKN1C, CDO1, CTNNB1
17MP:00053897.6IGF2, AFP, APC, CDKN1C, CDO1, CTNNB1
18MP:00053977.5THPO, IGF2, NQO2, APC, MPL, EPOR
19MP:00053847.4MGAT3, IGF2, APC, MPL, EPOR, H19
20MP:00053877.2APC, NQO2, IGF2, THPO, MPL, SERPINA6
21MP:00053786.7MPL, APC, CYP7A1, IGF2, EPOR, H19
22MP:00053866.7IGF2, CYP7A1, NQO2, AFP, APC, SERPINA6
23MP:00107686.5APC, AFP, CYP7A1, IGF2, MPL, EPOR
24MP:00053765.6OTC, MGAT3, IGF2, CYP7A1, NQO2, AFP

Publications for Hepatoblastoma

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Articles related to Hepatoblastoma:

(show top 50)    (show all 684)
idTitleAuthorsYear
1
Neonatal medical exposures and characteristics of low birth weight hepatoblastoma cases: a report from the Children's Oncology Group. (25044669)
2014
2
Unravelling the genetics of hepatoblastoma: Few mutations, what else? (25239079)
2014
3
Hepatoblastoma evaluated by 18F-fluoromethyl choline PET/CT. (23334143)
2013
4
Analysis of national and single-center incidence and survival after liver transplantation for hepatoblastoma: new trends and future opportunities. (23331862)
2013
5
Epigallocatechin-3-gallate inhibits hepatoblastoma growth by reactivating the Wnt inhibitor SFRP1. (24127655)
2013
6
Imaging analysis of hepatoblastoma resectability across neoadjuvant chemotherapy. (23845613)
2013
7
High mobility group AT-hook 2 is overexpressed in hepatoblastoma. (23134771)
2013
8
ER stress and ASK1-JNK activation contribute to oridonin-induced apoptosis and growth inhibition in cultured human hepatoblastoma HuH-6 cells. (23580093)
2013
9
Cytogenetics of hepatoblastoma. (22201954)
2012
10
Hepatoblastoma in an infant with paternal uniparental disomy 14. (23181499)
2012
11
A fetus with a huge neck mass and a large abdominal circumference--a rare case of sialoblastoma and hepatoblastoma. (22711473)
2012
12
Prognostic implications of serum alpha-fetoprotein response during treatment of hepatoblastoma. (21370433)
2011
13
Initial liver transplantation for unresectable hepatoblastoma after chemotherapy. (21910210)
2011
14
Hepatoblastoma with tumor extension through the inferior vena cava into the right atrium. (20479678)
2010
15
Sterol-regulatory-element-binding protein 2 and nuclear factor Y control human farnesyl diphosphate synthase expression and affect cell proliferation in hepatoblastoma cells. (20450493)
2010
16
Hepatoblastoma in association with bilateral polycystic kidneys. (21034924)
2010
17
Altered microRNA Expression Patterns in Hepatoblastoma Patients. (19701500)
2009
18
Overexpression of Dickkopf 3 in hepatoblastomas and hepatocellular carcinomas. (19437037)
2009
19
Arachidonic Acid Activates K-Cl-cotransport in HepG2 Human Hepatoblastoma Cells. (19915704)
2009
20
Treatment-related acute myelomonocytic leukemia with t(11;19) in a child following chemotherapy for hepatoblastoma. (17973320)
2008
21
Hepatoblastoma in a Noonan syndrome patient with a PTPN11 mutation. (18253957)
2008
22
In vitro and in vivo evaluation of photodynamic techniques for the experimental treatment of human hepatoblastoma and neuroblastoma: preliminary results. (19009300)
2008
23
Evaluation and treatment of hepatoblastoma. (16423617)
2006
24
Hepatoblastoma: why so many low-birth-weight infants? (16456653)
2006
25
Chromosome 7 aberrations in a young girl with myelodysplasia and hepatoblastoma: an unusual association. (16317299)
2006
26
Second case of hepatoblastoma in a young patient with Simpson-Golabi-Behmel syndrome. (16166055)
2005
27
Liver transplantation for hepatoblastoma: results from the International Society of Pediatric Oncology (SIOP) study SIOPEL-1 and review of the world experience. (14752798)
2004
28
Curative resection by superior hepatectomy for advanced hepatoblastoma facilitated by the presence of a large inferior right hepatic vein. (18333062)
2004
29
Brain metastases in hepatoblastoma. (15087112)
2004
30
Tamoxifen cytotoxicity in hepatoblastoma cells stably transfected with human CYP3A4. (15006542)
2004
31
Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas. (15221005)
2004
32
Improved survival outcome for hepatoblastoma based on an optimal chemotherapeutic regimen--a report from the study group for pediatric solid malignant tumors in the Kyushu area. (14966739)
2004
33
Hepatoblastoma in a girl with biliary atresia: coincidence or co-incidence. (15382280)
2004
34
Analysis of treatment outcome for children with recurrent or metastatic hepatoblastoma. (12768314)
2003
35
Serum alpha-fetoprotein screening for hepatoblastoma in children with Beckwith-Wiedemann syndrome or isolated hemihyperplasia. (12970646)
2003
36
Orthotopic liver transplantation for unresectable hepatoblastoma. (12352881)
2002
37
Hepatoblastoma: assessment of criteria for histologic classification. (12228903)
2002
38
Beta-catenin mutations and protein accumulation in all hepatoblastomas examined from B6C3F1 mice treated with anthraquinone or oxazepam. (10850429)
2000
39
Role of Ca2+ influx in the tert-butyl hydroperoxide-induced apoptosis of HepG2 human hepatoblastoma cells. (9873835)
1998
40
Thrombopoietin in patients with hepatoblastoma. (9766812)
1998
41
Hepatoblastoma and APC gene mutation in familial adenomatous polyposis. (9378405)
1997
42
Timing and magnitude of decline in alpha-fetoprotein levels in treated children with unresectable or metastatic hepatoblastoma are predictors of outcome: a report from the Children's Cancer Group. (9060563)
1997
43
Hepatoblastoma and APC gene mutation in familial adenomatous polyposis. (9038672)
1996
44
Differential effects of insulin and insulin-like growth factor I on the production of plasma steroid-binding globulins by human hepatoblastoma-derived (Hep G2) cells. (7536204)
1995
45
Establishment and characterization of a novel hepatoblastoma-derived cell line. (7595832)
1995
46
Identification of a human immunodeficiency virus type 1 TAR binding protein in human hepatoblastoma HepG2 cells that trans-activates HIV-1 LTR-directed gene expression. (8286041)
1994
47
Production of interleukin-1 beta and interleukin-6 in hepatoblastoma. (8383628)
1993
48
Combined cystic teratoma and hepatoblastoma of the liver. Probable divergent differentiation of an uncommitted hepatic precursor cell. (8221556)
1993
49
Epithelial and mixed hepatoblastoma in the adult. Histological observations and general considerations. (1317555)
1992
50
Hepatoblastoma, pigmented ocular fundus lesions and jaw lesions in Gardner syndrome. (3354603)
1988

Variations for Hepatoblastoma

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Expression for genes affiliated with Hepatoblastoma

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Expression patterns in normal tissues for genes affiliated with Hepatoblastoma

Search GEO for disease gene expression data for Hepatoblastoma.

Pathways for genes affiliated with Hepatoblastoma

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Compounds for genes affiliated with Hepatoblastoma

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Compounds related to Hepatoblastoma according to GeneCards/GeneDecks:

(show top 50)    (show all 97)
idCompoundScoreTop Affiliating Genes
11-hydroxyanthraquinone4410.4CTNNB1, APC
2methylazoxymethanol acetate4410.4CTNNB1, APC
3samp4410.3APC, CTNNB1
4megapoietin4410.2THPO, MPL
51,2-dimethylhydrazine4410.2APC, CTNNB1
6nap-24410.0H19, IGF2
7sodium bisulfite449.9APC, IGF2, CTNNB1
8thromboxane44 2410.7MPL, CYP7A1, THPO
9aspirin44 50 28 2412.7APC, MPL, CTNNB1, THPO
10methylcellulose449.5THPO, CTNNB1, IGF2, EPOR
11tgf beta1449.5IGF2, THPO, CTNNB1, AFP
12polyethylene glycol449.5IGF2, AFP, MPL, THPO
13rsai449.5H19, IGF2, OTC
14prostacyclin449.4APC, THPO, IGF2, CYP7A1
15triiodothyronine449.3CYP7A1, SERPINA6, IGF2
16vitamin d449.3AFP, CTNNB1, APC, IGF2
17tamoxifen44 50 28 1112.2IGF2, THPO, CTNNB1, SERPINA6
18polysaccharide449.2AFP, CTNNB1, THPO, MGAT3
19fatty acid449.2OTC, CTNNB1, SERPINA6, APC, AFP
20indomethacin44 28 61 1112.2APC, THPO, IGF2, SLC10A1
21acth449.2H19, IGF2, APC, SERPINA6, CDKN1C
22paraffin449.2AFP, IGF2, APC, EPOR, H19, CTNNB1
23paclitaxel44 50 1111.1THPO, CTNNB1, AFP, IGF2
24thymidine44 2410.0CTNNB1, THPO, IGF2, AFP, EPOR, H19
25glycogen44 2410.0IGF2, AFP, APC, CTNNB1, OTC
26chloramphenicol44 2 50 1112.0OTC, AFP, IGF2, CYP7A1
27glutamine449.0IGF2, AFP, APC, CTNNB1, OTC
28testosterone44 61 24 1112.0SLC10A1, CTNNB1, SERPINA6, APC, AFP, IGF2
29sodium44 2410.0APC, THPO, OTC, AFP, SLC10A1
30phosphatidylinositol449.0CTNNB1, EPOR, MPL, APC, IGF2, THPO
31vegf449.0IGF2, CTNNB1, AFP, THPO, MPL, EPOR
32butyrate448.9IGF2, CTNNB1, AFP, OTC, THPO
33dexamethasone44 50 28 1111.9THPO, SERPINA6, CTNNB1, AFP, CYP7A1, IGF2
345-aza-2deoxycytidine448.9CTNNB1, CDKN1C, THPO, H19, APC, IGF2
35cholesterol44 28 24 1111.9SERPINA6, AFP, CYP7A1, CDKN1C, SLC10A1
36iron44 249.8EPOR, MPL, AFP, CDO1, THPO
37agar448.8H19, CTNNB1, THPO, IGF2, AFP, MPL
38alanine448.7THPO, CTNNB1, EPOR, SERPINA6, MPL, AFP
39serine448.7SERPINA6, CTNNB1, EPOR, IGF2, MPL, APC
405fluorouracil448.7THPO, OTC, CTNNB1, MPL, IGF2, AFP
41progesterone44 28 61 24 1112.7IGF2, CTNNB1, SERPINA6, SLC10A1, CYP7A1, APC
42estrogen448.5CTNNB1, SERPINA6, APC, AFP, CYP7A1, IGF2
43steroid448.5SERPINA6, CTNNB1, H19, EPOR, AFP, CYP7A1
44oxygen44 249.4CYP7A1, AFP, EPOR, NQO2, CDO1, THPO
45retinoic acid44 249.3THPO, H19, MGAT3, CTNNB1, APC, AFP
46lipid448.2SERPINA6, OTC, EPOR, APC, CYP7A1, AFP
47tyrosine448.2H19, EPOR, MPL, APC, AFP, IGF2
48cysteine448.1IGF2, THPO, CTNNB1, EPOR, SERPINA6, MPL
49glucose448.1CYP7A1, SERPINA6, AFP, IGF2, THPO, EPOR
50oligonucleotide447.7CDO1, AFP, OTC, CTNNB1, THPO, IGF2

GO Terms for genes affiliated with Hepatoblastoma

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Cellular components related to Hepatoblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell-cell adherens junctionGO:00591310.0CTNNB1, APC
2beta-catenin destruction complexGO:0308779.7CTNNB1, APC

Biological processes related to Hepatoblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1canonical Wnt signaling pathway involved in negative regulation of apoptotic processGO:04433610.1CTNNB1, APC
2T cell differentiation in thymusGO:03307710.0CTNNB1, APC
3proximal/distal pattern formationGO:0099549.9APC, CTNNB1
4midgut developmentGO:0074949.6OTC, CTNNB1
5platelet activationGO:0301689.0MPL, IGF2, THPO

Molecular functions related to Hepatoblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cadherin bindingGO:04529610.0CTNNB1, APC

Products for genes affiliated with Hepatoblastoma

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Sources for Hepatoblastoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet