HBL
MCID: HPT022
MIFTS: 65

Hepatoblastoma (HBL) malady

Liver diseases, Cancer diseases categories

Summaries for Hepatoblastoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 Hepatoblastoma is an uncommon malignant liver neoplasm occurring in infants and children and composed of... more...

MalaCards: Hepatoblastoma, also known as HBL, is related to hepatocellular carcinoma and hepatitis. An important gene associated with Hepatoblastoma is AXIN1 (axin 1), and among its related pathways are Wnt / Hedgehog / Notch and Rho Family GTPases. The compounds oligonucleotide and progesterone have been mentioned in the context of this disorder. Affiliated tissues include liver, fetal liver and lung, and related mouse phenotypes are homeostasis/metabolism and mortality/aging.

Aliases & Classifications for Hepatoblastoma

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 22GTR, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 35MESH via Orphanet, 26ICD10 via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Liver diseases


Characteristics (Orphanet epidemiological data):

48
hepatoblastoma:
Inheritance: Sporadic; Age of onset: Childhood


Aliases & Descriptions:

hepatoblastoma 8 42 22 10 44 48 60
hbl 8


External Ids:

Disease Ontology8 DOID:687
NCIt39 C3728
MeSH34 D018197
SNOMED-CT via Orphanet57 45024009, 109843000
SNOMED-CT56 109843000, 45024009
UMLS via Orphanet61 C0206624
MESH via Orphanet35 D018197
ICD10 via Orphanet26 C22.2

Related Diseases for Hepatoblastoma

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Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Hepatoblastoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 124)
idRelated DiseaseScoreTop Affiliating Genes
1hepatocellular carcinoma30.8H19, APC, CTNNB1, MGAT3, AFP, IGF2
2hepatitis30.8MGAT3, AFP, THPO
3beckwith-wiedemann syndrome30.7H19, IGF2, CDKN1C, SLC22A18
4familial adenomatous polyposis30.6AXIN2, AXIN1, DKK1, CTNNB1, APC
5hepatitis b30.4MGAT3, AFP
6leukemia30.2H19, MGAT3, MPL, CDKN1C, EPOR, PLAG1
7adenocarcinoma30.1H19, APC, CTNNB1, AFP, CDKN1C, AXIN1
8acute leukemia30.0THPO, EPOR, MPL
9breast cancer29.8H19, APC, CTNNB1, IGF2, DKK1, CDKN1C
10hemihypertrophy29.8H19, IGF2, CDKN1C
11sarcoma29.8THPO, IGF2
12rhabdomyosarcoma29.8SLC22A18, IGF2, H19
13hypoglycemia29.8SERPINA6, CDKN1C, IGF2
14biliary atresia29.8SLC10A1, OTC
15pancytopenia29.8MPL, THPO
16thrombocytosis29.8THPO, EPOR, MPL
17meningioma29.8IGF2
18mixed hepatoblastoma10.5
19hepatitis a10.4
20hypobetalipoproteinemia, familial, 210.3
21neuroblastoma10.2
22macrotrabecular hepatoblastoma10.1
23aicardi syndrome10.1
24liver disease10.1
25peritonitis10.1
26cystic fibrosis10.0
27hepatitis c10.0
28gastrointestinal stromal tumor10.0
29diarrhea10.0
30laryngitis10.0
31simpson-golabi-behmel syndrome type 110.0
32hepatocellular carcinoma, somatic10.0
33hepatoblastoma, somatic10.0
34colorectal cancer10.0H19, APC, CTNNB1, IGF2, DKK1, CDKN1C
35adenoma10.0H19, APC, CTNNB1, IGF2, CDKN1C, AXIN2
36prostate cancer10.0APC, CTNNB1, IGF2, DKK1, AXIN1, EPOR
37stomach cancer10.0H19, APC, CTNNB1, AFP, CDKN1C, EPOR
38wilms tumor10.0H19, CTNNB1, IGF2, CDKN1C, SLC22A18
39choriocarcinoma10.0H19, AFP, IGF2, CDKN1C, EPOR
40squamous cell carcinoma10.0H19, APC, CTNNB1, CDKN1C, AXIN1, EPOR
41chronic myeloid leukemia10.0H19, MPL, CDKN1C, EPOR, THPO
42ovarian cancer10.0IGF2, AFP, CTNNB1, H19
43colon cancer10.0APC, CTNNB1, IGF2, AXIN2, EPOR
44liver cirrhosis10.0MGAT3, MPL, AFP, THPO
45myeloproliferative disorder10.0THPO, EPOR, MPL, H19
46gastric adenocarcinoma10.0APC, CTNNB1, AFP, EPOR
47endometrial carcinoma10.0APC, CTNNB1, IGF2, SERPINA6
48hepatocellular adenoma10.0APC, CTNNB1, AFP
49pancreatic cancer10.0CDKN1C, DKK1, CTNNB1
50refractory anemia10.0THPO, EPOR, MPL

Graphical network of the top 20 diseases related to Hepatoblastoma:



Diseases related to hepatoblastoma

Clinical Features for Hepatoblastoma

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Drugs & Therapeutics for Hepatoblastoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Hepatoblastoma

Drug clinical trials:

Search ClinicalTrials for Hepatoblastoma

Search NIH Clinical Center for Hepatoblastoma

Search CenterWatch for Hepatoblastoma

Genetic Tests for Hepatoblastoma

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Sources:
22GTR
See all sources

Genetic tests related to Hepatoblastoma:

id Genetic test Affiliating Genes
1 Hepatoblastoma22

Anatomical Context for Hepatoblastoma

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32MalaCards
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MalaCards organs/tissues related to Hepatoblastoma:

32
Liver, Fetal liver, Lung, Brain, Kidney, Heart, Breast, Prostate, Nk cells, Endothelial, Thyroid

Animal Models for Hepatoblastoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Hepatoblastoma:

36 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537611.8MPL, MGAT3, CTNNB1, APC, H19, AFP
2MP:001076811.7H19, APC, CTNNB1, MPL, AFP, IGF2
3MP:000538011.7H19, APC, CTNNB1, MPL, IGF2, DKK1
4MP:000538411.5H19, APC, CTNNB1, MGAT3, MPL, IGF2
5MP:000538211.5H19, APC, CTNNB1, IGF2, DKK1, CDKN1C
6MP:000536711.5H19, APC, CTNNB1, IGF2, DKK1, CDKN1C
7MP:000538511.4H19, APC, CTNNB1, IGF2, CDKN1C, CDO1
8MP:000537011.3H19, APC, CTNNB1, MGAT3, IGF2, EPOR
9MP:000537911.3H19, AFP, CDKN1C, CDO1, AXIN2, PLAG1
10MP:000537811.3H19, APC, CTNNB1, MPL, IGF2, CDKN1C
11MP:000538911.3APC, CTNNB1, AFP, CDKN1C, CDO1, PLAG1
12MP:000539011.3H19, APC, DKK1, CDKN1C, CDO1, AXIN1
13MP:000287311.2H19, APC, CTNNB1, MGAT3, CDKN1C, AXIN1
14MP:000539111.2H19, APC, DKK1, CDO1, AXIN2, PLAG1
15MP:000538611.2APC, CTNNB1, AFP, IGF2, CDKN1C, CDO1
16MP:000537111.1AXIN2, CDO1, DKK1, H19
17MP:000538711.1APC, CTNNB1, MPL, IGF2, CDKN1C, EPOR
18MP:000538811.0CTNNB1, IGF2, DKK1, CDO1, AXIN1, EPOR
19MP:000363111.0APC, DKK1, AXIN1, AXIN2, OTC
20MP:000301210.9APC, CTNNB1, IGF2, EPOR, SERPINA6, H19
21MP:000539710.8APC, CTNNB1, MPL, IGF2, CDKN1C, EPOR

Publications for Hepatoblastoma

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Sources:
50PubMed
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Articles related to Hepatoblastoma:

(show top 50)    (show all 666)
idTitleAuthorsYear
1
Dose-dense cisplatin-based chemotherapy and surgery for children with high-risk hepatoblastoma (SIOPEL-4): a prospective, single-arm, feasibility study. (23831416)
2013
2
Opioid growth factor (OGF) for hepatoblastoma: a novel non-toxic treatment. (23275062)
2013
3
A comparison between A^a8,F-FDG PET/CT imaging and biological and radiological findings in restaging of hepatoblastoma patients. (24063012)
2013
4
Correction: Resveratrol as a Pan-HDAC Inhibitor Alters the Acetylation Status of Jistone Proteins in Human-Derived Hepatoblastoma Cells. (24039676)
2013
5
Relapses in hepatoblastoma patients: clinical characteristics and outcome--experience of the International Childhood Liver Tumour Strategy Group (SIOPEL). (23146961)
2013
6
Cytogenetics of hepatoblastoma. (22201954)
2012
7
In vitro evaluation of the Aurora kinase inhibitor VX-680 for Hepatoblastoma. (22526548)
2012
8
Molecular imaging and photodynamic therapy in hepatoblastoma. (22201889)
2012
9
Engineered measles virus Edmonston strain used as a novel oncolytic viral system against human hepatoblastoma. (23009685)
2012
10
Sorafenib and bevacizumab for recurrent metastatic hepatoblastoma: stable radiographic disease with decreased AFP. (22492703)
2012
11
Hepatoblastoma in the neonatal period: An unusual presentation. (23326030)
2012
12
Initial liver transplantation for unresectable hepatoblastoma after chemotherapy. (21910210)
2011
13
MicroRNA-492 is processed from the keratin 19 gene and up-regulated in metastatic hepatoblastoma. (21319197)
2011
14
Hepatoblastoma with tumor extension through the inferior vena cava into the right atrium. (20479678)
2010
15
Mixed hepatoblastoma in child. Case report. (21173946)
2010
16
First report of ectopic ACTH syndrome and PTHrP-induced hypercalcemia due to a hepatoblastoma in a child. (20133447)
2010
17
The effect of differentiating and apoptotic agents on notch signalling pathway in hepatoblastoma. (21033247)
2010
18
Down-regulation of mTOR activity and survivin expression during tamoxifen-induced apoptosis in hepatoblastoma cells]. (21223797)
2010
19
Treatment and outcome of 14 children with hepatoblastoma]. (19558810)
2009
20
Comprehensive allelotyping of hepatoblastoma. (19453057)
2009
21
Redefining the role of doxorubicin for the treatment of children with hepatoblastoma. (18467729)
2008
22
Loss of imprinting of IGF2 correlates with hypermethylation of the H19 differentially methylated region in hepatoblastoma. (19034281)
2008
23
Staged resection for a ruptured hepatoblastoma: a 6-year follow-up. (17066271)
2007
24
Abdominal mass in a neonate: hepatoblastoma. (17978459)
2007
25
Adult hepatoblastoma in a female Down's. (17598340)
2007
26
Neoadjuvant chemotherapy before surgery of hepatoblastoma. (16936371)
2006
27
Thrombopoietin stimulates migration and activates multiple signaling pathways in hepatoblastoma cells. (16150872)
2006
28
Combined treatment of hepatoblastoma with transcatheter arterial chemoembolization and surgery. (16326406)
2006
29
Treatment of infantile hepatoblastoma and related complications. (16482940)
2005
30
Ruptured hepatoblastoma with massive internal bleeding in an adult. (16273660)
2005
31
Tamoxifen induces suppression of cell viability and apoptosis in the human hepatoblastoma cell line HepG2 via down-regulation of telomerase activity. (15102000)
2004
32
Hepatoblastoma--report of three cases. (15025365)
2003
33
Hepatoblastoma associated with Beckwith-Wiedemann syndrome and hemihypertrophy. (12721741)
2003
34
Treatment of unresectable and metastatic hepatoblastoma: a pediatric oncology group phase II study. (12177104)
2002
35
Mutational spectrum of beta-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas. (12101426)
2002
36
Effect of gemfibrozil on apolipoprotein B secretion and diacylglycerol acyltransferase activity in human hepatoblastoma (HepG2) cells. (12204791)
2002
37
Role of pertussis toxin-sensitive G-proteins in intracellular Ca2+ release and apoptosis induced by inhibiting cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channels in HepG2 human hepatoblastoma cells. (11180400)
2001
38
Beta-catenin mutations and protein accumulation in all hepatoblastomas examined from B6C3F1 mice treated with anthraquinone or oxazepam. (10850429)
2000
39
Overexpression of multidrug resistance genes MDR1 and cMOAT in human hepatocellular carcinoma and hepatoblastoma cell lines. (10427140)
1999
40
Mixed hepatoblastoma diagnosed by fine-needle aspiration biopsy cytology: a case report. (9784999)
1998
41
Hepatoblastoma and APC gene mutation in familial adenomatous polyposis. (9378405)
1997
42
Expression of cell adhesion molecules and common acute lymphoblastic leukaemia antigen in hepatoblastoma. (8972759)
1996
43
Down-regulation of thyroxine-binding globulin messenger ribonucleic acid by 3,5,3'-triiodothyronine in human hepatoblastoma cells. (7608285)
1995
44
A nuclear protein, synthesized in growth-arrested human hepatoblastoma cells, is a novel member of the short-chain alcohol dehydrogenase family. (7556196)
1995
45
Human hepatoblastoma cells (HepG2) and rat hepatoma cells are defective in important enzyme activities in the oxidation of the C27 steroid side chain in bile acid formation. (8301225)
1993
46
Characterization of amylin binding sites in a human hepatoblastoma cell line. (1337379)
1992
47
Human hepatocyte growth factor stimulates the growth of HUH-6 clone 5 human hepatoblastoma cells. (1312905)
1992
48
Hepatoblastoma, pigmented ocular fundus lesions and jaw lesions in Gardner syndrome. (3354603)
1988
49
Mixed hepatoblastoma in a young adult. (2846507)
1988
50
Mixed hepatoblastoma in the adult: case report and review of the literature. (6255014)
1980

Genetic Variations for Hepatoblastoma

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Expression for genes affiliated with Hepatoblastoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hepatoblastoma

Search GEO for disease gene expression data for Hepatoblastoma.

Pathways for genes affiliated with Hepatoblastoma

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Sources:
4Cell Signaling Technology, 51QIAGEN, 29KEGG, 52R&D Systems, 37NCBI BioSystems Database, 59Tocris Bioscience, 12EMD Millipore, 53Reactome
See all sources

Pathways related to Hepatoblastoma according to GeneCards/GeneDecks:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.9AXIN2, AXIN1, DKK1, AFP, CTNNB1, APC
2
Hide members
10.9APC, CTNNB1, IGF2, AXIN1, EPOR, THPO
3
Hide members
10.9APC, CTNNB1, IGF2, AXIN1, EPOR, THPO
410.9AXIN2, AXIN1, AFP, CTNNB1, APC
5
Hide members
10.9APC, CTNNB1, DKK1, AXIN1, AXIN2
610.8AXIN2, AXIN1, CTNNB1, APC
7
Hide members
10.8APC, CTNNB1, AXIN1, AXIN2
8
Hide members
10.8APC, CTNNB1, AXIN1, AXIN2
9
Hide members
10.8APC, CTNNB1, AXIN1, AXIN2
1010.8APC, CTNNB1, AXIN1, AXIN2
1110.8AXIN1, IGF2, CTNNB1, APC
12
Hide members
10.8AXIN1, DKK1, CTNNB1, APC
1310.8APC, CTNNB1, DKK1, AXIN1
1410.8APC, CTNNB1, DKK1, AXIN1
1510.8APC, CTNNB1, DKK1, AXIN1
1610.8APC, CTNNB1, DKK1, AXIN2
17
Hide members
10.7AXIN1, CTNNB1, APC
18
Cytoskeleton remodeling Reverse signaling by ephrin B
Hide members
10.7AXIN2, AXIN1, CTNNB1
1910.7CTNNB1, AXIN1, AXIN2
20
Hide members
10.7MGAT3, IGF2, AXIN1

Compounds for genes affiliated with Hepatoblastoma

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Sources:
44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB
See all sources

Compounds related to Hepatoblastoma according to GeneCards/GeneDecks:

(show top 50)    (show all 61)
idCompoundScoreTop Affiliating Genes
1oligonucleotide4411.6THPO, OTC, PLAG1, CDO1, IGF2, EPOR
2progesterone44 59 28 11 2415.5SLC10A1, DKK1, AFP, UGT2B4, IGF2, SERPINA6
3steroid4411.5CTNNB1, AFP, IGF2, EPOR, THPO, SERPINA6
4retinoic acid44 2412.5UGT2B4, AFP, H19, APC, CTNNB1, IGF2
5agar4411.5MPL, THPO, EPOR, IGF2, AFP, CTNNB1
6glycogen44 2412.5AFP, OTC, AXIN2, IGF2, DKK1, CTNNB1
7testosterone44 59 11 2414.4SERPINA6, SLC10A1, IGF2, UGT2B4, APC, CTNNB1
8alanine4411.4CTNNB1, MPL, AFP, IGF2, EPOR, THPO
9serine4411.4MPL, CTNNB1, APC, AFP, AXIN2, EPOR
105-aza-2deoxycytidine4411.4IGF2, THPO, CTNNB1, APC, H19, CDKN1C
115fluorouracil4411.4MPL, OTC, THPO, IGF2, AFP, CTNNB1
12cysteine4411.4CTNNB1, THPO, EPOR, CDO1, IGF2, SERPINA6
13paraffin4411.4AFP, APC, CTNNB1, H19, IGF2, EPOR
14thymidine44 2412.3AFP, CTNNB1, IGF2, H19, THPO, EPOR
15tyrosine4411.3MPL, EPOR, APC, H19, CTNNB1, THPO
16acth4411.3H19, SERPINA6, CDKN1C, IGF2, APC
17tamoxifen44 49 28 1114.2UGT2B4, CTNNB1, IGF2, THPO, SERPINA6
18vegf4411.2CTNNB1, EPOR, IGF2, AFP, MPL, THPO
19methylcellulose4411.2CTNNB1, IGF2, EPOR, THPO
20phosphatidylinositol4411.2APC, MPL, THPO, EPOR, IGF2, CTNNB1
21polyethylene glycol4411.2THPO, IGF2, AFP, MPL
22estrone44 28 11 2414.2AFP, UGT2B4, SERPINA6, IGF2
23glutamine4411.2APC, CTNNB1, AFP, OTC, IGF2
24threonine4411.2AFP, APC, CTNNB1, MPL, OTC, AXIN2
25iron44 2412.2THPO, EPOR, AFP, CDO1, MPL
26samp4411.2CTNNB1, APC, AXIN2
27glucose4411.1IGF2, OTC, SERPINA6, APC
28sodium bisulfite4411.1IGF2, APC, CTNNB1
29tgf beta14411.1THPO, IGF2, AFP, CTNNB1
30rsai4411.1H19, IGF2, OTC
31fatty acid4411.1APC, SERPINA6, OTC, CTNNB1
32sodium44 2412.0OTC, SLC10A1, APC, AFP, THPO
33butyrate4411.0THPO, OTC
34megapoietin4411.0THPO, MPL
35pidotimod4411.0AXIN2, CTNNB1
361-hydroxyanthraquinone4411.0CTNNB1, APC
37methylazoxymethanol acetate4411.0CTNNB1, APC
38sialic acid4411.0THPO, PLAG1
39aspirin44 49 28 2414.0APC, THPO, MPL, CTNNB1
40estrogen4411.0THPO
41dihydrotestosterone44 28 11 2414.0UGT2B4, SERPINA6
42nap-24411.0H19, IGF2
431,2-dimethylhydrazine4410.9APC, CTNNB1
44apai4410.8IGF2, H19
45acth 1-244410.7SERPINA6, IGF2
46lithium44 49 11 2413.7CTNNB1, DKK1, APC
47azoxymethane4410.7APC, CTNNB1
482-amino-3-methylimidazo(4,5-f)quinoline4410.6APC, CTNNB1
49anagrelide44 1111.5MPL, THPO
50indomethacin44 59 28 1113.5APC, IGF2, THPO, SLC10A1

GO Terms for genes affiliated with Hepatoblastoma

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Sources:
16Gene Ontology
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Cellular components related to Hepatoblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1beta-catenin destruction complexGO:03087710.8AXIN2, AXIN1, CTNNB1, APC
2cell cortexGO:00593810.7AXIN2, AXIN1, CTNNB1
3lateral plasma membraneGO:01632810.6APC, CTNNB1, AXIN1
4cytoplasmic microtubuleGO:00588110.4AXIN2, AXIN1, APC

Biological processes related to Hepatoblastoma according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of canonical Wnt receptor signaling pathwayGO:09009010.9AXIN2, AXIN1, DKK1, APC
2Wnt receptor signaling pathway involved in somitogenesisGO:09024410.9AXIN2, AXIN1, DKK1
3dorsal/ventral axis specificationGO:00995010.9CTNNB1, AXIN1, AXIN2
4regulation of centromeric sister chromatid cohesionGO:07060210.7CTNNB1, AXIN2
5cytoplasmic microtubule organizationGO:03112210.6AXIN1, APC
6midgut developmentGO:00749410.6OTC, CTNNB1
7canonical Wnt receptor signaling pathwayGO:06007010.6APC, CTNNB1, AXIN1
8positive regulation of protein phosphorylationGO:00193410.4AXIN2, AXIN1, IGF2

Molecular functions related to Hepatoblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein kinase bindingGO:01990110.8AXIN2, AXIN1, CTNNB1, APC
2I-SMAD bindingGO:07041110.8AXIN2, AXIN1, CTNNB1
3beta-catenin bindingGO:00801310.7AXIN2, AXIN1, APC
4signal transducer activityGO:00487110.7CTNNB1, DKK1, AXIN1, AXIN2
5armadillo repeat domain bindingGO:07001610.3AXIN2, AXIN1

Products for genes affiliated with Hepatoblastoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hepatoblastoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet