MCID: HPT022
MIFTS: 53

Hepatoblastoma malady

Rare diseases, Liver diseases, Cancer diseases categories

Aliases & Classifications for Hepatoblastoma

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Sources:
9Disease Ontology, 41NIH Rare Diseases, 11DISEASES, 43Novoseek, 47Orphanet, 22GTR, 60UMLS, 55SNOMED-CT, 33MeSH, 38NCIt, 34MESH via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet
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Hepatoblastoma, Aliases & Descriptions:

Name: Hepatoblastoma 9 41 11 43 47 22 60
 
Hbl 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Liver diseases


Characteristics (Orphanet epidemiological data):

47
hepatoblastoma:
Inheritance: Not applicable; Prevalence: <1/1000000 (Europe),1-9/1000000 (Europe); Age of onset: Childhood,Infancy,Neonatal


External Ids:

Disease Ontology9 DOID:687
MeSH33 D018197
NCIt38 C3728
Orphanet47 449
SNOMED-CT55 45024009, 109843000
MESH via Orphanet34 D018197
ICD10 via Orphanet26 C22.2
UMLS via Orphanet61 C0206624

Summaries for Hepatoblastoma

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Wikipedia:63 Hepatoblastoma is an uncommon malignant liver neoplasm occurring in infants and children and composed of... more...

MalaCards based summary: Hepatoblastoma, also known as hbl, is related to hepatitis and beckwith-wiedemann syndrome. An important gene associated with Hepatoblastoma is APC (adenomatous polyposis coli), and among its related pathways are Canonical Wnt signaling pathway and Wnt / Hedgehog / Notch. The compounds 1-hydroxyanthraquinone and methylazoxymethanol acetate have been mentioned in the context of this disorder. Affiliated tissues include liver, fetal liver and lung, and related mouse phenotypes are no phenotypic analysis and tumorigenesis.

Related Diseases for Hepatoblastoma

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Diseases related to Hepatoblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 134)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis31.3AFP, THPO, MGAT3
2beckwith-wiedemann syndrome30.7CDKN1C, H19, IGF2
3adenomatous polyposis coli30.6CTNNB1, APC
4purpura30.6THPO
5wilms tumor30.4CDKN1C, CTNNB1
6pancytopenia30.3THPO, MPL
7thrombocytosis30.2EPOR, THPO, MPL
8biliary atresia30.1OTC, SLC10A1
9adenocarcinoma30.0APC, CTNNB1, AFP, CDKN1C, H19, EPOR
10hypoglycemia29.7CDKN1C, SERPINA6, IGF2
11hepatocellular carcinoma29.7H19, EPOR, APC, CDKN1C, CTNNB1, OTC
12breast cancer29.6H19, CTNNB1, EPOR, IGF2
13leukemia29.6CDKN1C, MPL, THPO, MGAT3, OTC, EPOR
14mixed hepatoblastoma10.6
15polyposis, juvenile intestinal10.5APC
16gallbladder cancer10.5APC
17thrombocythemia 110.5THPO
18intestinal neoplasm10.5APC, CTNNB1
19desmoid disease, hereditary10.4APC, CTNNB1
20mismatch repair cancer syndrome10.4CTNNB1, APC
21acinar cell carcinoma10.4CTNNB1, AFP
22fibromatosis10.4APC, CTNNB1
23malignant mixed mullerian tumor10.4AFP, CTNNB1
24portal vein thrombosis10.4AFP, THPO
25hepatocellular adenoma10.4AFP, CTNNB1, APC
26tubular adenocarcinoma10.4CTNNB1, AFP
27emphysema due to aat deficiency10.4OTC
28thrombocytopenia, congenital amegakaryocytic10.4MPL, THPO
29peutz-jeghers syndrome10.4APC, CTNNB1
30thrombocytopenia due to platelet alloimmunization10.3MPL, THPO
31chronic myeloproliferative disease10.3MPL, THPO
32hypobetalipoproteinemia, familial, 210.3
33megakaryocytic leukemia10.3THPO, EPOR
34thrombocytopenic purpura, autoimmune10.3MPL, THPO
35neuroblastoma10.3
36hepatitis b10.3
37aicardi syndrome10.3
38simpson-golabi-behmel syndrome10.3
39essential thrombocythemia10.3MPL, THPO
40splenomegaly10.3THPO, MPL
41gestational trophoblastic tumor10.2CDKN1C, H19
42acute liver failure10.2THPO, OTC
43gastric adenocarcinoma10.2CTNNB1, APC, AFP, EPOR
44refractory anemia10.2EPOR, THPO, MPL
45polycythemia10.2EPOR, MPL, THPO
46macrotrabecular hepatoblastoma10.2
47polycythemia vera10.2EPOR, MPL, THPO
48neutropenia10.2MPL, THPO, EPOR
49silver-russell syndrome10.2H19, IGF2
50embryonal cancer10.2H19, IGF2

Graphical network of the top 20 diseases related to Hepatoblastoma:



Diseases related to hepatoblastoma

Symptoms for Hepatoblastoma

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Drugs & Therapeutics for Hepatoblastoma

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Drug clinical trials:

Search ClinicalTrials for Hepatoblastoma

Search NIH Clinical Center for Hepatoblastoma

Genetic Tests for Hepatoblastoma

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Genetic tests related to Hepatoblastoma:

id Genetic test Affiliating Genes
1 Hepatoblastoma22

Anatomical Context for Hepatoblastoma

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MalaCards organs/tissues related to Hepatoblastoma:

31
Liver, Fetal liver, Lung, Brain, Kidney, Heart, Thyroid, Breast, Prostate, Nk cells, Endothelial

Animal Models for Hepatoblastoma or affiliated genes

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MGI Mouse Phenotypes related to Hepatoblastoma:

35 (show all 24)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.9IGF2, APC, SERPINA6, EPOR, H19, CTNNB1
2MP:00020068.9MGAT3, NQO2, AFP, APC, H19, CTNNB1
3MP:00053818.7IGF2, CYP7A1, APC, H19, CDKN1C, CTNNB1
4MP:00028738.6MGAT3, APC, EPOR, H19, CDKN1C, CTNNB1
5MP:00053808.5IGF2, APC, MPL, EPOR, H19, CDKN1C
6MP:00053678.4IGF2, APC, SERPINA6, CDKN1C, CTNNB1, OTC
7MP:00053718.4IGF2, APC, CDKN1C, CDO1, CTNNB1
8MP:00107718.3IGF2, CYP7A1, NQO2, APC, CTNNB1, OTC
9MP:00053828.2IGF2, APC, CDKN1C, CDO1, CTNNB1
10MP:00053908.1IGF2, APC, H19, CDKN1C, CDO1, CTNNB1
11MP:00053918.1IGF2, CYP7A1, APC, CDKN1C, CDO1, CTNNB1
12MP:00053857.9CTNNB1, CDO1, CDKN1C, EPOR, APC, IGF2
13MP:00053887.9IGF2, EPOR, CDKN1C, CDO1, CTNNB1
14MP:00053707.8MGAT3, IGF2, CYP7A1, APC, SERPINA6, EPOR
15MP:00036317.8IGF2, APC, EPOR, H19, CDKN1C, CTNNB1
16MP:00053797.7IGF2, AFP, APC, CDKN1C, CDO1, CTNNB1
17MP:00053897.6IGF2, AFP, APC, CDKN1C, CDO1, CTNNB1
18MP:00053977.5THPO, IGF2, NQO2, APC, MPL, EPOR
19MP:00053847.4MGAT3, IGF2, APC, MPL, EPOR, H19
20MP:00053877.2APC, NQO2, IGF2, THPO, MPL, SERPINA6
21MP:00053786.7MPL, APC, CYP7A1, IGF2, EPOR, H19
22MP:00053866.7IGF2, CYP7A1, NQO2, AFP, APC, SERPINA6
23MP:00107686.5APC, AFP, CYP7A1, IGF2, MPL, EPOR
24MP:00053765.6OTC, MGAT3, IGF2, CYP7A1, NQO2, AFP

Publications for Hepatoblastoma

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Articles related to Hepatoblastoma:

(show top 50)    (show all 708)
idTitleAuthorsYear
1
Neonatal medical exposures and characteristics of low birth weight hepatoblastoma cases: a report from the Children's Oncology Group. (25044669)
2014
2
Unravelling the genetics of hepatoblastoma: Few mutations, what else? (25239079)
2014
3
Hepatoblastoma evaluated by 18F-fluoromethyl choline PET/CT. (23334143)
2013
4
Analysis of national and single-center incidence and survival after liver transplantation for hepatoblastoma: new trends and future opportunities. (23331862)
2013
5
Epigallocatechin-3-gallate inhibits hepatoblastoma growth by reactivating the Wnt inhibitor SFRP1. (24127655)
2013
6
Imaging analysis of hepatoblastoma resectability across neoadjuvant chemotherapy. (23845613)
2013
7
High mobility group AT-hook 2 is overexpressed in hepatoblastoma. (23134771)
2013
8
ER stress and ASK1-JNK activation contribute to oridonin-induced apoptosis and growth inhibition in cultured human hepatoblastoma HuH-6 cells. (23580093)
2013
9
Cytogenetics of hepatoblastoma. (22201954)
2012
10
Hepatoblastoma in an infant with paternal uniparental disomy 14. (23181499)
2012
11
Prognostic implications of serum alpha-fetoprotein response during treatment of hepatoblastoma. (21370433)
2011
12
Initial liver transplantation for unresectable hepatoblastoma after chemotherapy. (21910210)
2011
13
Hepatoblastoma with tumor extension through the inferior vena cava into the right atrium. (20479678)
2010
14
Sterol-regulatory-element-binding protein 2 and nuclear factor Y control human farnesyl diphosphate synthase expression and affect cell proliferation in hepatoblastoma cells. (20450493)
2010
15
Hepatoblastoma in association with bilateral polycystic kidneys. (21034924)
2010
16
Altered microRNA Expression Patterns in Hepatoblastoma Patients. (19701500)
2009
17
Overexpression of Dickkopf 3 in hepatoblastomas and hepatocellular carcinomas. (19437037)
2009
18
Arachidonic Acid Activates K-Cl-cotransport in HepG2 Human Hepatoblastoma Cells. (19915704)
2009
19
Treatment-related acute myelomonocytic leukemia with t(11;19) in a child following chemotherapy for hepatoblastoma. (17973320)
2008
20
Hepatoblastoma in a Noonan syndrome patient with a PTPN11 mutation. (18253957)
2008
21
Teratoid hepatoblastoma. (19065325)
2008
22
In vitro and in vivo evaluation of photodynamic techniques for the experimental treatment of human hepatoblastoma and neuroblastoma: preliminary results. (19009300)
2008
23
Evaluation and treatment of hepatoblastoma. (16423617)
2006
24
Hepatoblastoma: why so many low-birth-weight infants? (16456653)
2006
25
Chromosome 7 aberrations in a young girl with myelodysplasia and hepatoblastoma: an unusual association. (16317299)
2006
26
Second case of hepatoblastoma in a young patient with Simpson-Golabi-Behmel syndrome. (16166055)
2005
27
Liver transplantation for hepatoblastoma: results from the International Society of Pediatric Oncology (SIOP) study SIOPEL-1 and review of the world experience. (14752798)
2004
28
Hepatoblastoma and hepatocellular carcinoma in children. (15146904)
2004
29
Curative resection by superior hepatectomy for advanced hepatoblastoma facilitated by the presence of a large inferior right hepatic vein. (18333062)
2004
30
Brain metastases in hepatoblastoma. (15087112)
2004
31
Tamoxifen cytotoxicity in hepatoblastoma cells stably transfected with human CYP3A4. (15006542)
2004
32
Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas. (15221005)
2004
33
Improved survival outcome for hepatoblastoma based on an optimal chemotherapeutic regimen--a report from the study group for pediatric solid malignant tumors in the Kyushu area. (14966739)
2004
34
Hepatoblastoma in a girl with biliary atresia: coincidence or co-incidence. (15382280)
2004
35
Analysis of treatment outcome for children with recurrent or metastatic hepatoblastoma. (12768314)
2003
36
Orthotopic liver transplantation for unresectable hepatoblastoma. (12352881)
2002
37
Hepatoblastoma: assessment of criteria for histologic classification. (12228903)
2002
38
Beta-catenin mutations and protein accumulation in all hepatoblastomas examined from B6C3F1 mice treated with anthraquinone or oxazepam. (10850429)
2000
39
Role of Ca2+ influx in the tert-butyl hydroperoxide-induced apoptosis of HepG2 human hepatoblastoma cells. (9873835)
1998
40
Thrombopoietin in patients with hepatoblastoma. (9766812)
1998
41
Hepatoblastoma and APC gene mutation in familial adenomatous polyposis. (9378405)
1997
42
Timing and magnitude of decline in alpha-fetoprotein levels in treated children with unresectable or metastatic hepatoblastoma are predictors of outcome: a report from the Children's Cancer Group. (9060563)
1997
43
Hepatoblastoma and APC gene mutation in familial adenomatous polyposis. (9038672)
1996
44
Differential effects of insulin and insulin-like growth factor I on the production of plasma steroid-binding globulins by human hepatoblastoma-derived (Hep G2) cells. (7536204)
1995
45
Establishment and characterization of a novel hepatoblastoma-derived cell line. (7595832)
1995
46
Identification of a human immunodeficiency virus type 1 TAR binding protein in human hepatoblastoma HepG2 cells that trans-activates HIV-1 LTR-directed gene expression. (8286041)
1994
47
Production of interleukin-1 beta and interleukin-6 in hepatoblastoma. (8383628)
1993
48
Combined cystic teratoma and hepatoblastoma of the liver. Probable divergent differentiation of an uncommitted hepatic precursor cell. (8221556)
1993
49
Epithelial and mixed hepatoblastoma in the adult. Histological observations and general considerations. (1317555)
1992
50
Hepatoblastoma, pigmented ocular fundus lesions and jaw lesions in Gardner syndrome. (3354603)
1988

Variations for Hepatoblastoma

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Expression for genes affiliated with Hepatoblastoma

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Search GEO for disease gene expression data for Hepatoblastoma.

Pathways for genes affiliated with Hepatoblastoma

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Compounds for genes affiliated with Hepatoblastoma

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Compounds related to Hepatoblastoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 97)
idCompoundScoreTop Affiliating Genes
11-hydroxyanthraquinone4310.4CTNNB1, APC
2methylazoxymethanol acetate4310.4CTNNB1, APC
3samp4310.3APC, CTNNB1
4megapoietin4310.2THPO, MPL
51,2-dimethylhydrazine4310.2APC, CTNNB1
6nap-24310.0H19, IGF2
7sodium bisulfite439.9APC, IGF2, CTNNB1
8thromboxane43 2410.7MPL, CYP7A1, THPO
9aspirin43 49 28 2412.7APC, MPL, CTNNB1, THPO
10methylcellulose439.5THPO, CTNNB1, IGF2, EPOR
11tgf beta1439.5IGF2, THPO, CTNNB1, AFP
12polyethylene glycol439.5IGF2, AFP, MPL, THPO
13rsai439.5H19, IGF2, OTC
14prostacyclin439.4APC, THPO, IGF2, CYP7A1
15triiodothyronine439.3CYP7A1, SERPINA6, IGF2
16vitamin d439.3AFP, CTNNB1, APC, IGF2
17tamoxifen43 49 28 1212.2IGF2, THPO, CTNNB1, SERPINA6
18polysaccharide439.2AFP, CTNNB1, THPO, MGAT3
19fatty acid439.2OTC, CTNNB1, SERPINA6, APC, AFP
20indomethacin43 28 59 1212.2APC, THPO, IGF2, SLC10A1
21acth439.2H19, IGF2, APC, SERPINA6, CDKN1C
22paraffin439.2AFP, IGF2, APC, EPOR, H19, CTNNB1
23paclitaxel43 49 1211.1THPO, CTNNB1, AFP, IGF2
24thymidine43 2410.0CTNNB1, THPO, IGF2, AFP, EPOR, H19
25glycogen43 2410.0IGF2, AFP, APC, CTNNB1, OTC
26chloramphenicol43 2 49 1212.0OTC, AFP, IGF2, CYP7A1
27glutamine439.0IGF2, AFP, APC, CTNNB1, OTC
28testosterone43 59 24 1212.0SLC10A1, CTNNB1, SERPINA6, APC, AFP, IGF2
29sodium43 2410.0APC, THPO, OTC, AFP, SLC10A1
30phosphatidylinositol439.0CTNNB1, EPOR, MPL, APC, IGF2, THPO
31vegf439.0IGF2, CTNNB1, AFP, THPO, MPL, EPOR
32butyrate438.9IGF2, CTNNB1, AFP, OTC, THPO
33dexamethasone43 49 28 1211.9THPO, SERPINA6, CTNNB1, AFP, CYP7A1, IGF2
345-aza-2deoxycytidine438.9CTNNB1, CDKN1C, THPO, H19, APC, IGF2
35cholesterol43 28 24 1211.9SERPINA6, AFP, CYP7A1, CDKN1C, SLC10A1
36iron43 249.8EPOR, MPL, AFP, CDO1, THPO
37agar438.8H19, CTNNB1, THPO, IGF2, AFP, MPL
38alanine438.7THPO, CTNNB1, EPOR, SERPINA6, MPL, AFP
39serine438.7SERPINA6, CTNNB1, EPOR, IGF2, MPL, APC
405fluorouracil438.7THPO, OTC, CTNNB1, MPL, IGF2, AFP
41progesterone43 28 59 24 1212.7IGF2, CTNNB1, SERPINA6, SLC10A1, CYP7A1, APC
42estrogen438.5CTNNB1, SERPINA6, APC, AFP, CYP7A1, IGF2
43steroid438.5SERPINA6, CTNNB1, H19, EPOR, AFP, CYP7A1
44oxygen43 249.4CYP7A1, AFP, EPOR, NQO2, CDO1, THPO
45retinoic acid43 249.3THPO, H19, MGAT3, CTNNB1, APC, AFP
46lipid438.2SERPINA6, OTC, EPOR, APC, CYP7A1, AFP
47tyrosine438.2H19, EPOR, MPL, APC, AFP, IGF2
48cysteine438.1IGF2, THPO, CTNNB1, EPOR, SERPINA6, MPL
49glucose438.1CYP7A1, SERPINA6, AFP, IGF2, THPO, EPOR
50oligonucleotide437.7CDO1, AFP, OTC, CTNNB1, THPO, IGF2

GO Terms for genes affiliated with Hepatoblastoma

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Cellular components related to Hepatoblastoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell-cell adherens junctionGO:000591310.0CTNNB1, APC
2beta-catenin destruction complexGO:00308779.7CTNNB1, APC

Biological processes related to Hepatoblastoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1canonical Wnt signaling pathway involved in negative regulation of apoptotic processGO:004433610.1CTNNB1, APC
2T cell differentiation in thymusGO:003307710.0CTNNB1, APC
3proximal/distal pattern formationGO:00099549.9APC, CTNNB1
4midgut developmentGO:00074949.6OTC, CTNNB1
5platelet activationGO:00301689.0MPL, IGF2, THPO

Molecular functions related to Hepatoblastoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cadherin bindingGO:004529610.0CTNNB1, APC

Products for genes affiliated with Hepatoblastoma

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Sources for Hepatoblastoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet