MCID: HPT067
MIFTS: 44

Hepatocellular Adenoma malady

Liver diseases, Cancer diseases, Rare diseases categories
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Summaries for Hepatocellular Adenoma

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65Wikipedia, 33MalaCards
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Wikipedia:65 Hepatocellular adenoma, also hepatic adenoma, or rarely hepadenoma, is an uncommon benign liver tumor... more...

MalaCards: Hepatocellular Adenoma, also known as adenoma hepatocellular, is related to adenoma and hepatocellular carcinoma. An important gene associated with Hepatocellular Adenoma is HNF1A (HNF1 homeobox A), and among its related pathways are Glucose / Energy Metabolism and FOXA2 and FOXA3 transcription factor networks. The compounds udpglucose and uric acid have been mentioned in the context of this disorder. Affiliated tissues include liver, placenta and bone, and related mouse phenotypes are renal/urinary system and liver/biliary system.

Aliases & Classifications for Hepatocellular Adenoma

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8Disease Ontology, 49Orphanet, 62UMLS, 45Novoseek, 36MESH via Orphanet, 26ICD10 via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Liver diseases


Characteristics (Orphanet epidemiological data):

49
hepatocellular adenoma:
Age of onset: Adulthood


Aliases & Descriptions:

hepatocellular adenoma 8 49 62
adenoma hepatocellular 45


External Ids:

Disease Ontology8 DOID:0050868
MESH via Orphanet36 D018248
ICD10 via Orphanet26 D13.4
SNOMED-CT via Orphanet59 78058005
UMLS via Orphanet63 C0206669

Related Diseases for Hepatocellular Adenoma

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Hepatocellular Adenoma:



Diseases related to hepatocellular adenoma

Symptoms for Hepatocellular Adenoma

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Drugs & Therapeutics for Hepatocellular Adenoma

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Hepatocellular Adenoma

Search NIH Clinical Center for Hepatocellular Adenoma

Genetic Tests for Hepatocellular Adenoma

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Anatomical Context for Hepatocellular Adenoma

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33MalaCards
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MalaCards organs/tissues related to Hepatocellular Adenoma:

33
Liver, Placenta, Bone, Bone marrow, Ovary, Uterus, Testes

Animal Models for Hepatocellular Adenoma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Hepatocellular Adenoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.9SLC37A4, HNF1A, G6PC
2MP:00053707.5SLC37A4, HNF1A, FABP1, G6PC, MLXIPL
3MP:00053767.3MLXIPL, G6PC, FABP1, HNF1A, SLC37A4

Publications for Hepatocellular Adenoma

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52PubMed
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Articles related to Hepatocellular Adenoma:

(show top 50)    (show all 179)
idTitleAuthorsYear
1
Outcomes of liver resection in hepatocellular adenoma and focal nodular hyperplasia. (23509949)
2014
2
Diagnostic utility and limitations of glutamine synthetase and serum amyloid-associated protein immunohistochemistry in the distinction of focal nodular hyperplasia and inflammatory hepatocellular adenoma. (23807780)
2014
3
I^-catenin activated hepatocellular adenoma. (23837144)
2013
4
Case of telangiectatic/inflammatory hepatocellular adenoma arising in a patient with primary sclerosing cholangitis. (22568458)
2012
5
Hepatocellular adenoma associated with long-term exposure to phenobarbital: a paediatric case report. (22124572)
2012
6
Hepatocellular carcinoma arising from hepatocellular adenoma in a hepatitis B virus-associated cirrhotic liver. (22079485)
2012
7
Characteristics and distinguishing features of hepatocellular adenoma and focal nodular hyperplasia on gadoxetate disodium-enhanced MRI. (22194486)
2012
8
Hepatocellular adenoma: a rare benign tumor of the liver. (22472417)
2012
9
Liver-specific contrast agent-enhanced magnetic resonance and A^a8,F-fluorodeoxyglucose positron emission tomography findings of hepatocellular adenoma: report of a case. (22160355)
2012
10
Somatic mutations activating STAT3 in human inflammatory hepatocellular adenomas. (21690253)
2011
11
Management of hepatocellular adenoma during pregnancy. (21094555)
2011
12
Hepatocellular adenoma containing hepatocellular carcinoma in a male patient with familial adenomatous polyposis coli: Report of a case. (21922375)
2011
13
Systematic review of hepatocellular adenoma in China and other regions. (21175790)
2011
14
Subtype classification of hepatocellular adenoma. (20357450)
2010
15
Loss of hepatocyte nuclear factor 1alpha function in human hepatocellular adenomas leads to aberrant activation of signaling pathways involved in tumorigenesis. (20041408)
2010
16
Spectrum of HNF1A somatic mutations in hepatocellular adenoma differs from that in patients with MODY3 and suggests genotoxic damage. (20393147)
2010
17
A Hepatocellular Adenoma in a Diet-induced Obese Mouse. (22319226)
2010
18
Surgical management of spontaneous ruptured hepatocellular adenoma. (19690662)
2009
19
Hepatocellular adenoma management and phenotypic classification: the Bordeaux experience. (19585623)
2009
20
Clonality and allelotype analyses of focal nodular hyperplasia compared with hepatocellular adenoma and carcinoma. (19787833)
2009
21
Hepatocellular adenoma in a male with familial adenomatous polyposis coli. (19288049)
2009
22
Molecular pathogenesis of focal nodular hyperplasia and hepatocellular adenoma. (17997499)
2008
23
Management of a giant ruptured hepatocellular adenoma. Report of a case. (19582184)
2007
24
Hepatocellular adenoma in a Eurasian otter (Lutra lutra). (17322782)
2007
25
Hepatocellular adenoma displaying a HNF1alpha inactivation in a patient with familial adenomatous polyposis coli. (17049664)
2006
26
Case-orientated approach to the management of hepatocellular adenoma. (17051603)
2006
27
Successful treatment of hepatocellular adenoma with percutaneous radiofrequency ablation. (15728604)
2005
28
Images in hepatology. Telangiectatic adenoma: a variant of hepatocellular adenoma. (15657559)
2004
29
Hepatocellular adenoma and focal nodular hyperplasia after long-term use of danazol for endometriosis: a case report. (15221322)
2004
30
Kupffer cell function of hepatocellular adenoma: pulse sequence effects in superparamagnetic iron oxide-enhanced magnetic resonance imaging. (15242510)
2004
31
Concomitant hepatocellular adenoma and adenomatous hyperplasia in a patient without cirrhosis. (12632534)
2003
32
Danazol-induced hepatocellular adenoma in patients with hereditary angio-oedema. (11983460)
2002
33
Idiopathic hepatocellular adenoma with intratumoral haemorrhage. (11943966)
2002
34
Diagnostic impact of fluorescence in situ hybridization in the differentiation of hepatocellular adenoma and well-differentiated hepatocellular carcinoma. (11333302)
2001
35
Focal nodular hyperplasia and hepatocellular adenoma of the liver: differentiation with multiphasic helical CT. (11373219)
2001
36
Hepatocellular adenoma: multiphasic CT and histopathologic findings in 25 patients. (10715059)
2000
37
Retrospective analysis of 29 patients surgically treated for hepatocellular adenoma or focal nodular hyperplasia. (11100357)
2000
38
Hepatocellular adenoma of the placenta: report of a case associated with maternal bicornuate uterus and fetal renal dysplasia. (10971709)
2000
39
Management of focal nodular hyperplasia and hepatocellular adenoma. (10414183)
1999
40
Radiology case of the month. Incidental liver mass found on abdominal CT. Hepatocellular adenoma. (9677782)
1998
41
Childhood hepatocellular adenoma in familial adenomatous polyposis: mutations in adenomatous polyposis coli gene and p53. (9041254)
1997
42
Severe upper abdominal pain due to a large hepatocellular adenoma. (9260490)
1997
43
Solitary hepatocellular adenoma in infancy. (9269027)
1997
44
Hepatocellular adenoma in a beta-thalassemic woman having secondary iron overload. (7798835)
1994
45
Hepatocellular adenoma with a high level of alpha fetoprotein. Apropos of a case observed in the Central hospital of YaoundAc, Cameroon]. (1284392)
1992
46
Hepatocellular adenoma of the placenta. (3013034)
1986
47
A hepatocellular adenoma in a rattlesnake. (6292263)
1982
48
Liver adenoma with granulomas. The appearance of granulomas in oral contraceptive-related hepatocellular adenoma and in the surrounding nontumorous liver. (6896136)
1982
49
Complete regression of hepatocellular adenoma after withdrawal of oral contraceptives. (6271517)
1981
50
The association between oral contraception and hepatocellular adenoma--a preliminary report. (203498)
1977

Variations for Hepatocellular Adenoma

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Expression for genes affiliated with Hepatocellular Adenoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hepatocellular Adenoma

Search GEO for disease gene expression data for Hepatocellular Adenoma.

Pathways for genes affiliated with Hepatocellular Adenoma

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Sources:
50PathCards, 5Cell Signaling Technology, 38NCBI BioSystems Database, 55Reactome, 30KEGG, 60Thomson Reuters
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Pathways related to Hepatocellular Adenoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6HNF1A, FABP1
29.5HNF1A, G6PC
3
Show member pathways
9.4UGT2B7, G6PC
4
Show member pathways
9.3SLC37A4, G6PC
5
Show member pathways
glycolysis38
gluconeogenesis38
Glycolysis and Gluconeogenesis38
9.3G6PC, SLC37A4
69.3G6PC, SLC37A4
7
Show member pathways
7.5G6PC, MLXIPL, FABP1, SLC37A4, UGT2B7

Compounds for genes affiliated with Hepatocellular Adenoma

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45Novoseek, 24HMDB, 11DrugBank, 29IUPHAR, 61Tocris Bioscience, 51PharmGKB
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Compounds related to Hepatocellular Adenoma according to GeneCards/GeneDecks:

(show all 15)
idCompoundScoreTop Affiliating Genes
1udpglucose459.6G6PC, UGT2B7
2uric acid45 2410.4SLC37A4, G6PC
3phosphoenolpyruvate45 1110.4G6PC, FABP1, HNF1A
4glucose 6-phosphate45 2410.3SLC37A4, G6PC
5cholesterol45 29 24 1112.2HNF1A, FABP1, G6PC
6troglitazone45 29 61 1112.1G6PC, UGT2B7
7steroid459.1UGT2B7, G6PC, HNF1A
8retinoic acid45 2410.1HNF1A, FABP1, UGT2B7
9dexamethasone45 51 29 1112.0G6PC, FABP1, HNF1A
10pyruvate459.0MLXIPL, G6PC, HNF1A
11leucine458.9MLXIPL, G6PC, HNF1A
12sterol458.5HNF1A, FABP1, G6PC, MLXIPL
13fatty acid458.5HNF1A, FABP1, G6PC, MLXIPL
14lipid458.5MLXIPL, G6PC, FABP1, HNF1A
15glucose457.4SLC37A4, MLXIPL, UGT2B7, G6PC, FABP1, HNF1A

GO Terms for genes affiliated with Hepatocellular Adenoma

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16Gene Ontology
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Cellular components related to Hepatocellular Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of endoplasmic reticulum membraneGO:0301769.0SLC37A4, G6PC
2endoplasmic reticulum membraneGO:0057898.8SLC37A4, G6PC, UGT2B7

Biological processes related to Hepatocellular Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glucose-6-phosphate transportGO:0157609.3SLC37A4, G6PC
2glucose transportGO:0157589.3SLC37A4, G6PC
3hexose transportGO:0086459.2G6PC, SLC37A4
4glucose homeostasisGO:0425938.2SLC37A4, HNF1A, G6PC, MLXIPL
5small molecule metabolic processGO:0442817.8SLC37A4, FABP1, G6PC, MLXIPL

Products for genes affiliated with Hepatocellular Adenoma

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Sources for Hepatocellular Adenoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet