MCID: HPT067
MIFTS: 42

Hepatocellular Adenoma malady

Categories: Liver diseases, Rare diseases, Cancer diseases

Aliases & Classifications for Hepatocellular Adenoma

Aliases & Descriptions for Hepatocellular Adenoma:

Name: Hepatocellular Adenoma 12 56 14 69

Characteristics:

Orphanet epidemiological data:

56
hepatocellular adenoma
Age of onset: Adult;

Classifications:

Orphanet: 56  
Rare hepatic diseases


External Ids:

Disease Ontology 12 DOID:0050868
Orphanet 56 ORPHA54272
MESH via Orphanet 43 D018248
UMLS via Orphanet 70 C0206669
ICD10 via Orphanet 34 D13.4

Summaries for Hepatocellular Adenoma

MalaCards based summary : Hepatocellular Adenoma is related to hepatic adenoma, somatic and adenoma. An important gene associated with Hepatocellular Adenoma is GLUL (Glutamate-Ammonia Ligase), and among its related pathways/superpathways are Metabolism and Cytochrome P450 - arranged by substrate type. The drugs Melphalan and Sorafenib have been mentioned in the context of this disorder. Affiliated tissues include liver, placenta and bone, and related phenotypes are homeostasis/metabolism and liver/biliary system

Wikipedia : 71 Hepatocellular adenoma, also hepatic adenoma, or rarely hepadenoma, is an uncommon benign liver tumor... more...

Related Diseases for Hepatocellular Adenoma

Graphical network of the top 20 diseases related to Hepatocellular Adenoma:



Diseases related to Hepatocellular Adenoma

Symptoms & Phenotypes for Hepatocellular Adenoma

MGI Mouse Phenotypes related to Hepatocellular Adenoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.61 CTNNB1 CYP1A1 CYP1A2 FABP1 G6PC GLUL
2 liver/biliary system MP:0005370 9.28 HNF1A MLXIPL SREBF1 CTNNB1 CYP1A1 CYP1A2

Drugs & Therapeutics for Hepatocellular Adenoma

Drugs for Hepatocellular Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 47)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Melphalan Approved Phase 2 148-82-3 4053 460612
2
Sorafenib Approved, Investigational Phase 1, Phase 2 284461-73-0 216239 406563
3
Bevacizumab Approved, Investigational Phase 2 216974-75-3
4
Everolimus Approved Phase 2 159351-69-6 6442177
5
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
6
Sirolimus Approved, Investigational Phase 2 53123-88-9 5284616 6436030 46835353
7
Folic Acid Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 59-30-3 6037
8
Niacin Approved, Investigational, Nutraceutical Phase 1, Phase 2 59-67-6 938
9
Nicotinamide Approved, Nutraceutical Phase 1, Phase 2 98-92-0 936
10 Alkylating Agents Phase 2
11 Antineoplastic Agents, Alkylating Phase 2
12 Immunosuppressive Agents Phase 2
13 Liver Extracts Phase 2,Phase 1
14 Protein Kinase Inhibitors Phase 1, Phase 2
15 Angiogenesis Inhibitors Phase 2
16 Angiogenesis Modulating Agents Phase 2
17 Vitamin B Complex Phase 1, Phase 2
18 Antibodies Phase 1, Phase 2
19 Antibodies, Monoclonal Phase 1, Phase 2
20 Immunoglobulins Phase 1, Phase 2
21 Micronutrients Phase 1, Phase 2
22 Nicotinic Acids Phase 1, Phase 2
23 Trace Elements Phase 1, Phase 2
24 Vitamins Phase 1, Phase 2
25 Anti-Bacterial Agents Phase 2
26 Antibiotics, Antitubercular Phase 2
27 Antifungal Agents Phase 2
28 Anti-Infective Agents Phase 2
29 Endothelial Growth Factors Phase 2
30 Immunoglobulin G Phase 2
31 Mitogens Phase 2
32 Cola Nutraceutical Phase 2
33 Folate Nutraceutical Phase 1, Phase 2
34 Vitamin B9 Nutraceutical Phase 1, Phase 2
35 Vitamin B3 Nutraceutical Phase 1, Phase 2
36
Cisplatin Approved Phase 1 15663-27-1 84093 441203 2767
37
Pemetrexed Approved, Investigational Phase 1 150399-23-8, 137281-23-3 446556 60843
38
leucovorin Approved, Nutraceutical Phase 1 58-05-9 54575, 6560146 143
39
Erlotinib Hydrochloride Phase 1 183319-69-9 176871
40 Folic Acid Antagonists Phase 1
41 Nucleic Acid Synthesis Inhibitors Phase 1
42 arginine Nutraceutical Phase 1
43
Sunitinib Approved, Investigational 341031-54-7, 557795-19-4 5329102
44
Pancrelipase Approved 53608-75-6
45 Hematinics
46 Gastrointestinal Agents
47 pancreatin

Interventional clinical trials:

(show all 13)
id Name Status NCT ID Phase
1 Isolated Hepatic Perfusion With Melphalan in Treating Patients With Primary Unresectable Liver Cancer or Liver Metastases Completed NCT00019786 Phase 2
2 Internal Radiation Therapy for Hepatocellular Carcinomas With Therasphere: Optimized Dosimetry Versus Standard Dosimetry Recruiting NCT02582034 Phase 2
3 Sorafenib and TRC105 in Hepatocellular Cancer Active, not recruiting NCT01306058 Phase 1, Phase 2
4 Temsirolimus and Bevacizumab in Treating Patients With Advanced Endometrial, Ovarian, Liver, Carcinoid, or Islet Cell Cancer Active, not recruiting NCT01010126 Phase 2
5 Erlotinib in Treating Patients With Solid Tumors and Liver or Kidney Dysfunction Completed NCT00030498 Phase 1
6 Ph 1 Study in Subjects With Tumors Requiring Arginine to Assess ADI-PEG 20 With Pemetrexed and Cisplatin Recruiting NCT02029690 Phase 1
7 CBT-501 Study for Select Advanced or Relapsed/Recurrent Solid Tumors Recruiting NCT03053466 Phase 1
8 Liver MRI With Primovist/Eovist in Pediatric Subjects Who Are Suspected or Have Focal Liver Lesions. Completed NCT01043523
9 Quality of Life After Liver Resection Completed NCT00681499
10 A Continuation Study Using Sunitinib Malate For Patients Leaving Treatment On A Previous Sunitinib Study. Completed NCT00428220
11 Observational Study of Biomarker During Liver Surgery Recruiting NCT02102971
12 LRP1 and Colon Cancer Recruiting NCT02788669
13 Tissue Procurement for Gastric Cancer, Gastrointestinal Stromal Tumors (GIST), Esophageal Cancer, Pancreas Cancer, Hepatocellular Cancer, Biliary Cancer, Neuroendocrine, Peritoneal Mesothelioma, Anal Cancer and Colorectal Cancer in Patients Undergoing Sur Recruiting NCT01416714

Search NIH Clinical Center for Hepatocellular Adenoma

Genetic Tests for Hepatocellular Adenoma

Anatomical Context for Hepatocellular Adenoma

MalaCards organs/tissues related to Hepatocellular Adenoma:

39
Liver, Placenta, Bone, Bone Marrow, Ovary, Testes, Pancreas

Publications for Hepatocellular Adenoma

Articles related to Hepatocellular Adenoma:

(show top 50) (show all 249)
id Title Authors Year
1
Hepatocellular adenoma: when and how to treat? Update of current evidence. ( 27803743 )
2016
2
Malignant transformation of hepatocellular adenoma with bone marrow metaplasia arising in glycogen storage disease type I: A case report. ( 27900094 )
2016
3
Evidence of good prognosis of hepatocellular adenoma in post-menopausal women. ( 27524464 )
2016
4
Combined use of heat-shock protein 70 and glutamine synthetase is useful in the distinction of typical hepatocellular adenoma from atypical hepatocellular neoplasms and well-differentiated hepatocellular carcinoma. ( 26769138 )
2016
5
Benign hepatocellular nodules of healthy liver: focal nodular hyperplasia and hepatocellular adenoma. ( 27189732 )
2016
6
A Pigmented hepatocellular adenoma with I^-catenin activation: case report and literature review. ( 27236161 )
2016
7
Malignant Transformation of Hepatocellular Adenoma. ( 27988517 )
2016
8
Hepatocellular adenoma classification: a comparative evaluation of immunohistochemistry and targeted mutational analysis. ( 26961851 )
2016
9
Response to 'The management of hepatocellular adenoma in obese patients: issues to consider'. ( 26767571 )
2016
10
Hepatocellular adenoma with malignant transformation in a patient with neonatal portal vein thrombosis. ( 27042773 )
2016
11
Hepatocellular adenoma among adult survivors of childhood and young adult cancer. ( 27781382 )
2016
12
Touch cytology smear of an inflammatory hepatocellular adenoma displaying an unusual pattern: A case report. ( 27434199 )
2016
13
PET-avid hepatocellular adenomas: incidental findings associated with HNF1-I+ mutated lesions. ( 26776850 )
2016
14
European experience of 573 liver resections for hepatocellular adenoma: a cross-sectional study by the AFC-HCA-2013 study group. ( 27593592 )
2016
15
Hepatocellular Adenoma of the Placenta With Updated Immunohistochemical and Molecular Markers: A Case Report. ( 27106781 )
2016
16
Hepatoblastoma Arising in a Pigmented I^-catenin-activated Hepatocellular Adenoma: Case Report and Review of the Literature. ( 27096257 )
2016
17
Outcomes of liver resection for haemorrhagic hepatocellular adenoma. ( 26805568 )
2016
18
Hepatocellular adenoma: comparison between real-time contrast-enhanced ultrasound and dynamic computed tomography. ( 27386395 )
2016
19
Molecular Classification of Hepatocellular Adenoma Associates With Risk Factors, Bleeding, and Malignant Transformation. ( 27939373 )
2016
20
Contrast-enhanced ultrasonographic findings of serum amyloid A-positive hepatocellular neoplasm: Does hepatocellular adenoma arise in cirrhotic liver? ( 27660679 )
2016
21
Ultrasound features of hepatocellular adenoma and the additional value of contrast-enhanced ultrasound. ( 26818543 )
2016
22
Distinction Between Inflammatory Hepatocellular Adenoma and Mass Effect on Liver Sampling. ( 27989788 )
2016
23
Correlation of exon 3 I^-catenin mutations with glutamine synthetase staining patterns in hepatocellular adenoma and hepatocellular carcinoma. ( 27469330 )
2016
24
LATE SURGICAL TREATMENT FOR SPONTANEOUS RUPTURE OF HEPATOCELLULAR ADENOMA: CASE REPORT. ( 26734808 )
2015
25
Hepatocellular Adenomas and Carcinoma in Asymptomatic, Non-Cirrhotic Type III Glycogen Storage Disease. ( 26697579 )
2015
26
Morphologic and Molecular Features of Hepatocellular Adenoma with Gadoxetic Acid-enhanced MR Imaging. ( 25985059 )
2015
27
Hepatocellular adenoma with malignant transformation in male patients with non-cirrhotic livers. ( 26058379 )
2015
28
The Evolving Role of Nonalcoholic Fatty Liver Disease in Hepatic Neoplasia: Inflammatory Hepatocellular Adenoma in a Man with Metabolic Syndrome. ( 26378649 )
2015
29
Hepatocellular adenoma: An update. ( 26557953 )
2015
30
Focal nodular hyperplasia and hepatocellular adenoma: The value of shear wave elastography for differential diagnosis. ( 26299323 )
2015
31
Giant hepatocellular adenoma with peliosis hepatis in a child: A diagnostic dilemma. ( 27522744 )
2015
32
Differentiation of focal nodular hyperplasia from hepatocellular adenoma: Role of the quantitative analysis of gadobenate dimeglumine-enhanced hepatobiliary phase MRI. ( 25851028 )
2015
33
Focal Nodular Hyperplasia and Hepatocellular Adenoma: Accuracy of Gadoxetic Acid-enhanced MR Imaging-A Systematic Review. ( 26599935 )
2015
34
Gd-EOB-DTPA-Enhanced Magnetic Resonance Findings of a Giant Inflammatory Hepatocellular Adenoma: a Case Report and Review of the Literature. ( 25894634 )
2015
35
Giant hepatocellular adenoma in a previously obese thirteen-year-old boy. ( 26019045 )
2015
36
Simultaneous occurrence of focal nodular hyperplasia and HNF1A-inactivated hepatocellular adenoma: a collision tumor simulating a composite FNH-HCA. ( 26274031 )
2015
37
Malignant transformation of hepatocellular adenoma: how frequently does it happen? ( 26020024 )
2015
38
A case of inflammatory hepatocellular adenoma displaying an unusual histological pattern. ( 26589902 )
2015
39
Focal Nodular Hyperplasia and Hepatocellular Adenoma: Accuracy of Gadoxetic Acid-enhanced MR Imaging-A Systematic Review. ( 26020440 )
2015
40
Current updates on the molecular genetics and magnetic resonance imaging of focal nodular hyperplasia and hepatocellular adenoma. ( 25790815 )
2015
41
Contrast-enhanced ultrasound in combination with color Doppler ultrasound can improve the diagnostic performance of focal nodular hyperplasia and hepatocellular adenoma. ( 25701530 )
2015
42
Minimal hepatic glucose-6-phosphatase-I+ activity required to sustain survival and prevent hepatocellular adenoma formation in murine glycogen storage disease type Ia. ( 26937391 )
2015
43
The management of hepatocellular adenoma in obese patients: issues to consider. ( 26386199 )
2015
44
A case of I^-catenin-positive hepatocellular adenoma with MR imaging sign of diffuse intratumoral fat deposition. ( 25875860 )
2015
45
Multiple hepatocellular adenomas presenting in a male 8 years post-pancreaticoduodenectomy for islet cell tumor of the pancreas. ( 25810673 )
2015
46
Hepatocellular adenoma management: Call for shared guidelines and multidisciplinary approach. ( 25434466 )
2015
47
Unique genetic alterations and clinicopathological features of hepatocellular adenoma in Chinese population. ( 26608415 )
2015
48
NF-I_B/RelA and Nrf2 cooperate to maintain hepatocyte integrity and to prevent development of hepatocellular adenoma. ( 26348541 )
2015
49
Fenofibrate-induced massive regression of mutiple inflammatory hepatocellular adenoma. ( 26572747 )
2015
50
Risk factors for bleeding in hepatocellular adenoma. ( 24760723 )
2014

Variations for Hepatocellular Adenoma

Expression for Hepatocellular Adenoma

Search GEO for disease gene expression data for Hepatocellular Adenoma.

Pathways for Hepatocellular Adenoma

Pathways related to Hepatocellular Adenoma according to GeneCards Suite gene sharing:

(show all 26)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.79 CYP1A1 CYP1A2 CYP3A4 FABP1 G6PC GLUL
2
Show member pathways
13.02 CYP1A1 CYP1A2 CYP3A4 GSTP1 UGT2B7
3
Show member pathways
12.42 CYP1A1 CYP1A2 CYP3A4 GSTP1 UGT2B7
4
Show member pathways
12.32 CYP3A4 G6PC MLXIPL SREBF1
5 12.23 CYP1A2 CYP3A4 FABP1 HNF1A SREBF1
6
Show member pathways
12.03 CYP1A1 CYP1A2 CYP3A4
7 11.87 CTNNB1 HNF1A SREBF1
8
Show member pathways
11.77 G6PC MLXIPL SREBF1
9
Show member pathways
11.55 CYP1A1 CYP1A2 CYP3A4
10
Show member pathways
11.52 CYP1A1 CYP1A2 CYP3A4 GSTP1
11
Show member pathways
11.42 CYP1A2 CYP3A4 UGT2B7
12
Show member pathways
11.39 CYP1A1 CYP1A2 CYP3A4
13
Show member pathways
11.36 CYP1A1 CYP1A2 CYP3A4 UGT2B7
14
Show member pathways
11.24 CYP1A1 CYP1A2 CYP3A4 UGT2B7
15 11.2 CYP1A1 CYP1A2
16 11.17 CYP1A2 CYP3A4
17 11.14 CYP3A4 MLXIPL SREBF1
18
Show member pathways
11.04 CYP1A2 CYP3A4
19
Show member pathways
10.98 CYP3A4 UGT2B7
20 10.95 CYP1A2 CYP3A4
21 10.88 CYP3A4 UGT2B7
22
Show member pathways
10.79 CYP1A1 CYP1A2 CYP3A4 UGT2B7
23 10.74 CYP3A4 GSTP1
24 10.66 CYP1A1 CYP1A2
25 10.3 CYP1A1 CYP1A2 CYP3A4 GSTP1
26 10.21 CYP3A4 UGT2B7

GO Terms for Hepatocellular Adenoma

Cellular components related to Hepatocellular Adenoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein complex GO:0043234 9.65 CTNNB1 FABP1 GLUL HNF1A SREBF1
2 endoplasmic reticulum membrane GO:0005789 9.63 CYP1A1 CYP1A2 CYP3A4 G6PC SREBF1 UGT2B7
3 transcription factor complex GO:0005667 9.5 CTNNB1 HNF1A MLXIPL
4 organelle membrane GO:0031090 9.26 CYP1A1 CYP1A2 CYP3A4 UGT2B7
5 intracellular membrane-bounded organelle GO:0043231 9.17 CYP1A1 CYP1A2 CYP3A4 G6PC GLUL SREBF1

Biological processes related to Hepatocellular Adenoma according to GeneCards Suite gene sharing:

(show all 31)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.95 CTNNB1 HNF1A MLXIPL SREBF1
2 regulation of transcription from RNA polymerase II promoter GO:0006357 9.94 CTNNB1 HNF1A MLXIPL SREBF1
3 lipid metabolic process GO:0006629 9.94 CYP1A2 CYP3A4 SREBF1 UGT2B7
4 response to drug GO:0042493 9.88 CTNNB1 CYP1A1 CYP1A2 SREBF1
5 regulation of gene expression GO:0010468 9.82 CTNNB1 CYP1A2 G6PC
6 response to organic cyclic compound GO:0014070 9.79 CYP1A1 CYP1A2 SREBF1
7 glucose homeostasis GO:0042593 9.77 G6PC HNF1A MLXIPL
8 response to estradiol GO:0032355 9.76 CTNNB1 CYP1A2 GSTP1
9 lung development GO:0030324 9.74 CTNNB1 CYP1A2 SREBF1
10 xenobiotic metabolic process GO:0006805 9.71 CYP1A2 CYP3A4 GSTP1
11 response to glucose GO:0009749 9.67 GLUL HNF1A SREBF1
12 response to immobilization stress GO:0035902 9.63 CYP1A1 CYP1A2
13 bone resorption GO:0045453 9.63 CTNNB1 HNF1A
14 epoxygenase P450 pathway GO:0019373 9.62 CYP1A1 CYP1A2
15 androgen metabolic process GO:0008209 9.61 CYP3A4 UGT2B7
16 cellular response to copper ion GO:0071280 9.61 CYP1A1 CYP1A2
17 exogenous drug catabolic process GO:0042738 9.59 CYP1A2 CYP3A4
18 vitamin D metabolic process GO:0042359 9.56 CYP1A1 CYP3A4
19 hydrogen peroxide biosynthetic process GO:0050665 9.55 CYP1A1 CYP1A2
20 oxidative demethylation GO:0070989 9.52 CYP1A2 CYP3A4
21 omega-hydroxylase P450 pathway GO:0097267 9.51 CYP1A1 CYP1A2
22 drug catabolic process GO:0042737 9.48 CYP1A2 CYP3A4
23 heterocycle metabolic process GO:0046483 9.46 CYP1A2 CYP3A4
24 monoterpenoid metabolic process GO:0016098 9.43 CYP1A2 CYP3A4
25 porphyrin-containing compound metabolic process GO:0006778 9.4 CYP1A1 CYP1A2
26 steroid catabolic process GO:0006706 9.37 CYP1A2 CYP3A4
27 drug metabolic process GO:0017144 9.33 CYP1A1 CYP1A2 CYP3A4
28 lipid hydroxylation GO:0002933 9.32 CYP1A1 CYP3A4
29 dibenzo-p-dioxin metabolic process GO:0018894 9.26 CYP1A1 CYP1A2
30 response to food GO:0032094 9.13 CYP1A1 G6PC SREBF1
31 steroid metabolic process GO:0008202 9.1 CYP1A1 CYP1A2 CYP3A4 G6PC SREBF1 UGT2B7

Molecular functions related to Hepatocellular Adenoma according to GeneCards Suite gene sharing:

(show all 16)
id Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.81 CTNNB1 CYP1A1 CYP1A2 CYP3A4
2 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 9.8 CTNNB1 HNF1A MLXIPL SREBF1
3 transcription regulatory region DNA binding GO:0044212 9.73 CTNNB1 HNF1A SREBF1
4 protein dimerization activity GO:0046983 9.72 HNF1A MLXIPL SREBF1
5 iron ion binding GO:0005506 9.71 CYP1A1 CYP1A2 CYP3A4
6 heme binding GO:0020037 9.7 CYP1A1 CYP1A2 CYP3A4
7 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.63 CYP1A1 CYP1A2 CYP3A4
8 monooxygenase activity GO:0004497 9.54 CYP1A1 CYP1A2 CYP3A4
9 steroid hydroxylase activity GO:0008395 9.48 CYP1A1 CYP3A4
10 estrogen 16-alpha-hydroxylase activity GO:0101020 9.43 CYP1A1 CYP3A4
11 oxygen binding GO:0019825 9.43 CYP1A1 CYP1A2 CYP3A4
12 demethylase activity GO:0032451 9.4 CYP1A1 CYP1A2
13 caffeine oxidase activity GO:0034875 9.32 CYP1A2 CYP3A4
14 vitamin D 24-hydroxylase activity GO:0070576 9.16 CYP1A1 CYP3A4
15 aromatase activity GO:0070330 9.13 CYP1A1 CYP1A2 CYP3A4
16 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 8.8 CYP1A1 CYP1A2 CYP3A4

Sources for Hepatocellular Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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