MCID: HPT067
MIFTS: 44

Hepatocellular Adenoma malady

Liver diseases, Cancer diseases, Rare diseases categories
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Summaries for Hepatocellular Adenoma

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Wikipedia:65 Hepatocellular adenoma, also hepatic adenoma, or rarely hepadenoma, is an uncommon benign liver tumor... more...

MalaCards based summary: Hepatocellular Adenoma, also known as adenoma hepatocellular, is related to adenoma and glycogen storage disease. An important gene associated with Hepatocellular Adenoma is HNF1A (HNF1 homeobox A), and among its related pathways are Glucose / Energy Metabolism and FOXA2 and FOXA3 transcription factor networks. The compounds udpglucose and uric acid have been mentioned in the context of this disorder. Affiliated tissues include liver, placenta and bone marrow, and related mouse phenotypes are renal/urinary system and liver/biliary system.

Aliases & Classifications for Hepatocellular Adenoma

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Sources:
8Disease Ontology, 48Orphanet, 62UMLS, 44Novoseek, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet
See all sources

Hepatocellular Adenoma, Aliases & Descriptions:

Name: Hepatocellular Adenoma 8 48 62
 
Adenoma Hepatocellular 44


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Liver diseases


Characteristics (Orphanet epidemiological data):

48
hepatocellular adenoma:
Age of onset: Adulthood


External Ids:

Disease Ontology8 DOID:0050868
MESH via Orphanet35 D018248
ICD10 via Orphanet26 D13.4
UMLS via Orphanet63 C0206669

Related Diseases for Hepatocellular Adenoma

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Graphical network of the top 20 diseases related to Hepatocellular Adenoma:



Diseases related to hepatocellular adenoma

Symptoms for Hepatocellular Adenoma

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Drugs & Therapeutics for Hepatocellular Adenoma

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Drug clinical trials:

Search ClinicalTrials for Hepatocellular Adenoma

Search NIH Clinical Center for Hepatocellular Adenoma

Genetic Tests for Hepatocellular Adenoma

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Anatomical Context for Hepatocellular Adenoma

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MalaCards organs/tissues related to Hepatocellular Adenoma:

32
Liver, Placenta, Bone marrow, Bone, Ovary, Uterus, Testes

Animal Models for Hepatocellular Adenoma or affiliated genes

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MGI Mouse Phenotypes related to Hepatocellular Adenoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.9SLC37A4, G6PC, HNF1A
2MP:00053707.5MLXIPL, G6PC, FABP1, HNF1A, SLC37A4
3MP:00053767.3SLC37A4, MLXIPL, G6PC, FABP1, HNF1A

Publications for Hepatocellular Adenoma

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Articles related to Hepatocellular Adenoma:

(show top 50)    (show all 197)
idTitleAuthorsYear
1
Outcomes of liver resection in hepatocellular adenoma and focal nodular hyperplasia. (23509949)
2014
2
Diagnostic utility and limitations of glutamine synthetase and serum amyloid-associated protein immunohistochemistry in the distinction of focal nodular hyperplasia and inflammatory hepatocellular adenoma. (23807780)
2014
3
Glutamine synthetase interpretation in hepatocellular adenoma. (25216583)
2014
4
Risk factors for bleeding in hepatocellular adenoma. (24760723)
2014
5
I^-Catenin activated hepatocellular adenoma: a report of three cases in Korea. (25071913)
2014
6
Hepatocellular adenoma: different entities for a single lesion. (24927616)
2014
7
I^-catenin activated hepatocellular adenoma. (23837144)
2013
8
Case of telangiectatic/inflammatory hepatocellular adenoma arising in a patient with primary sclerosing cholangitis. (22568458)
2012
9
Hepatocellular adenoma associated with long-term exposure to phenobarbital: a paediatric case report. (22124572)
2012
10
Hepatocellular carcinoma arising from hepatocellular adenoma in a hepatitis B virus-associated cirrhotic liver. (22079485)
2012
11
Characteristics and distinguishing features of hepatocellular adenoma and focal nodular hyperplasia on gadoxetate disodium-enhanced MRI. (22194486)
2012
12
Hepatocellular adenoma: a rare benign tumor of the liver. (22472417)
2012
13
Somatic mutations activating STAT3 in human inflammatory hepatocellular adenomas. (21690253)
2011
14
Management of hepatocellular adenoma during pregnancy. (21094555)
2011
15
Hepatocellular adenoma containing hepatocellular carcinoma in a male patient with familial adenomatous polyposis coli: Report of a case. (21922375)
2011
16
Systematic review of hepatocellular adenoma in China and other regions. (21175790)
2011
17
Subtype classification of hepatocellular adenoma. (20357450)
2010
18
Loss of hepatocyte nuclear factor 1alpha function in human hepatocellular adenomas leads to aberrant activation of signaling pathways involved in tumorigenesis. (20041408)
2010
19
Spectrum of HNF1A somatic mutations in hepatocellular adenoma differs from that in patients with MODY3 and suggests genotoxic damage. (20393147)
2010
20
Surgical management of spontaneous ruptured hepatocellular adenoma. (19690662)
2009
21
Hepatocellular adenoma management and phenotypic classification: the Bordeaux experience. (19585623)
2009
22
Clonality and allelotype analyses of focal nodular hyperplasia compared with hepatocellular adenoma and carcinoma. (19787833)
2009
23
Hepatocellular adenoma in a male with familial adenomatous polyposis coli. (19288049)
2009
24
Molecular pathogenesis of focal nodular hyperplasia and hepatocellular adenoma. (17997499)
2008
25
Management of a giant ruptured hepatocellular adenoma. Report of a case. (19582184)
2007
26
Hepatocellular adenoma in a Eurasian otter (Lutra lutra). (17322782)
2007
27
Hepatocellular adenoma displaying a HNF1alpha inactivation in a patient with familial adenomatous polyposis coli. (17049664)
2006
28
Case-orientated approach to the management of hepatocellular adenoma. (17051603)
2006
29
Successful treatment of hepatocellular adenoma with percutaneous radiofrequency ablation. (15728604)
2005
30
Images in hepatology. Telangiectatic adenoma: a variant of hepatocellular adenoma. (15657559)
2004
31
Hepatocellular adenoma and focal nodular hyperplasia after long-term use of danazol for endometriosis: a case report. (15221322)
2004
32
Concomitant hepatocellular adenoma and adenomatous hyperplasia in a patient without cirrhosis. (12632534)
2003
33
Danazol-induced hepatocellular adenoma in patients with hereditary angio-oedema. (11983460)
2002
34
Idiopathic hepatocellular adenoma with intratumoral haemorrhage. (11943966)
2002
35
Diagnostic impact of fluorescence in situ hybridization in the differentiation of hepatocellular adenoma and well-differentiated hepatocellular carcinoma. (11333302)
2001
36
Focal nodular hyperplasia and hepatocellular adenoma of the liver: differentiation with multiphasic helical CT. (11373219)
2001
37
Hepatocellular adenoma: multiphasic CT and histopathologic findings in 25 patients. (10715059)
2000
38
Retrospective analysis of 29 patients surgically treated for hepatocellular adenoma or focal nodular hyperplasia. (11100357)
2000
39
Hepatocellular adenoma of the placenta: report of a case associated with maternal bicornuate uterus and fetal renal dysplasia. (10971709)
2000
40
Management of focal nodular hyperplasia and hepatocellular adenoma. (10414183)
1999
41
Childhood hepatocellular adenoma in familial adenomatous polyposis: mutations in adenomatous polyposis coli gene and p53. (9041254)
1997
42
Severe upper abdominal pain due to a large hepatocellular adenoma. (9260490)
1997
43
Hepatocellular adenoma in a beta-thalassemic woman having secondary iron overload. (7798835)
1994
44
Hepatocellular adenoma with a high level of alpha fetoprotein. Apropos of a case observed in the Central hospital of YaoundAc, Cameroon]. (1284392)
1992
45
Primary hepatocellular adenoma in men. (2541173)
1989
46
Hepatocellular adenoma of the placenta. (3013034)
1986
47
A hepatocellular adenoma in a rattlesnake. (6292263)
1982
48
Liver adenoma with granulomas. The appearance of granulomas in oral contraceptive-related hepatocellular adenoma and in the surrounding nontumorous liver. (6896136)
1982
49
Complete regression of hepatocellular adenoma after withdrawal of oral contraceptives. (6271517)
1981
50
The association between oral contraception and hepatocellular adenoma--a preliminary report. (203498)
1977

Variations for Hepatocellular Adenoma

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Expression for genes affiliated with Hepatocellular Adenoma

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Expression patterns in normal tissues for genes affiliated with Hepatocellular Adenoma

Search GEO for disease gene expression data for Hepatocellular Adenoma.

Pathways for genes affiliated with Hepatocellular Adenoma

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Pathways related to Hepatocellular Adenoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6HNF1A, FABP1
29.5HNF1A, G6PC
3
Show member pathways
9.4UGT2B7, G6PC
4
Show member pathways
9.3SLC37A4, G6PC
5
Show member pathways
glycolysis37
gluconeogenesis37
Glycolysis and Gluconeogenesis37
9.3G6PC, SLC37A4
69.3G6PC, SLC37A4
7
Show member pathways
7.5G6PC, MLXIPL, FABP1, SLC37A4, UGT2B7

Compounds for genes affiliated with Hepatocellular Adenoma

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Compounds related to Hepatocellular Adenoma according to GeneCards/GeneDecks:

(show all 15)
idCompoundScoreTop Affiliating Genes
1udpglucose449.6UGT2B7, G6PC
2uric acid44 2410.4G6PC, SLC37A4
3phosphoenolpyruvate44 1110.4HNF1A, FABP1, G6PC
4glucose 6-phosphate44 2410.3SLC37A4, G6PC
5cholesterol44 28 24 1112.2FABP1, G6PC, HNF1A
6troglitazone44 28 61 1112.1G6PC, UGT2B7
7steroid449.1UGT2B7, HNF1A, G6PC
8retinoic acid44 2410.1UGT2B7, FABP1, HNF1A
9dexamethasone44 50 28 1112.0HNF1A, FABP1, G6PC
10pyruvate449.0G6PC, MLXIPL, HNF1A
11leucine448.9MLXIPL, G6PC, HNF1A
12sterol448.5HNF1A, FABP1, G6PC, MLXIPL
13fatty acid448.5HNF1A, FABP1, G6PC, MLXIPL
14lipid448.5G6PC, HNF1A, FABP1, MLXIPL
15glucose447.4SLC37A4, HNF1A, FABP1, G6PC, UGT2B7, MLXIPL

GO Terms for genes affiliated with Hepatocellular Adenoma

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Cellular components related to Hepatocellular Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of endoplasmic reticulum membraneGO:0301769.0SLC37A4, G6PC
2endoplasmic reticulum membraneGO:0057898.8SLC37A4, G6PC, UGT2B7

Biological processes related to Hepatocellular Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glucose-6-phosphate transportGO:0157609.3SLC37A4, G6PC
2glucose transportGO:0157589.3G6PC, SLC37A4
3hexose transportGO:0086459.2SLC37A4, G6PC
4glucose homeostasisGO:0425938.2HNF1A, MLXIPL, G6PC, SLC37A4
5small molecule metabolic processGO:0442817.8SLC37A4, FABP1, G6PC, MLXIPL

Products for genes affiliated with Hepatocellular Adenoma

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Sources for Hepatocellular Adenoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet