MCID: HPT067
MIFTS: 43

Hepatocellular Adenoma

Categories: Liver diseases, Rare diseases, Cancer diseases

Aliases & Classifications for Hepatocellular Adenoma

MalaCards integrated aliases for Hepatocellular Adenoma:

Name: Hepatocellular Adenoma 12 55 14 69

Characteristics:

Orphanet epidemiological data:

55
hepatocellular adenoma
Age of onset: Adult;

Classifications:

Orphanet: 55  
Rare hepatic diseases


External Ids:

Disease Ontology 12 DOID:0050868
Orphanet 55 ORPHA54272
MESH via Orphanet 42 D018248
UMLS via Orphanet 70 C0206669
ICD10 via Orphanet 33 D13.4
UMLS 69 C0206669

Summaries for Hepatocellular Adenoma

MalaCards based summary : Hepatocellular Adenoma is related to hepatic adenomas, familial and hepatocellular carcinoma. An important gene associated with Hepatocellular Adenoma is GLUL (Glutamate-Ammonia Ligase), and among its related pathways/superpathways are Metabolism and Cytochrome P450 - arranged by substrate type. The drugs Epinephrine and Racepinephrine have been mentioned in the context of this disorder. Affiliated tissues include liver, bone marrow and placenta, and related phenotypes are homeostasis/metabolism and liver/biliary system

Wikipedia : 72 Hepatocellular adenoma (also known as hepatic adenoma or hepadenoma) is a rare, benign liver tumor. It... more...

Related Diseases for Hepatocellular Adenoma

Diseases related to Hepatocellular Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Related Disease Score Top Affiliating Genes
1 hepatic adenomas, familial 32.5 CTNNB1 G6PC HNF1A
2 hepatocellular carcinoma 28.7 CTNNB1 CYP1A1 G6PC GLUL GSTP1 HNF1A
3 adenoma 10.9
4 glycogen storage disease 10.3
5 hepatitis 10.1
6 glycogen storage disease ia 10.0
7 body mass index quantitative trait locus 11 10.0
8 body mass index quantitative trait locus 9 10.0
9 body mass index quantitative trait locus 8 10.0
10 body mass index quantitative trait locus 4 10.0
11 body mass index quantitative trait locus 10 10.0
12 body mass index quantitative trait locus 7 10.0
13 body mass index quantitative trait locus 12 10.0
14 body mass index quantitative trait locus 14 10.0
15 body mass index quantitative trait locus 18 10.0
16 familial adenomatous polyposis 10.0
17 glycogen storage disease due to glucose-6-phosphatase deficiency 10.0
18 aging 9.8
19 episodic pain syndrome, familial, 1 9.8
20 liver disease 9.8
21 polycystic ovary syndrome 9.8
22 hemosiderosis 9.8
23 amyloidosis 9.8
24 fatty liver disease 9.8
25 blood group--diego system 9.7
26 complement hyperactivation, angiopathic thrombosis, and protein-losing enteropathy 9.7
27 fanconi anemia, complementation group a 9.7
28 body mass index quantitative trait locus 1 9.7
29 cholangitis, primary sclerosing 9.7
30 beta-thalassemia 9.7
31 alpha-fetoprotein deficiency 9.7
32 deficiency anemia 9.7
33 hepatitis b 9.7
34 islet cell tumor 9.7
35 thalassemia 9.7
36 thrombosis 9.7
37 glucose intolerance 9.7
38 portal vein thrombosis 9.7
39 iron deficiency anemia 9.7
40 sclerosing cholangitis 9.7
41 iron metabolism disease 9.7
42 endometriosis 9.7
43 hepatoblastoma 9.7
44 peliosis hepatis 9.7
45 cholangitis 9.7
46 congenital hepatic fibrosis 9.7
47 nodular regenerative hyperplasia 9.7
48 glycogen storage disease due to glycogen branching enzyme deficiency 9.7
49 renal dysplasia 9.7
50 kleptomania 9.4 CYP1A2 CYP3A4

Graphical network of the top 20 diseases related to Hepatocellular Adenoma:



Diseases related to Hepatocellular Adenoma

Symptoms & Phenotypes for Hepatocellular Adenoma

MGI Mouse Phenotypes related to Hepatocellular Adenoma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.81 CYP1A2 FABP1 G6PC GLUL HNF1A IL6ST
2 liver/biliary system MP:0005370 9.56 FABP1 G6PC GLUL HNF1A IL6ST CTNNB1
3 normal MP:0002873 9.1 G6PC GLUL IL6ST ASS1 CTNNB1 CYP1A1

Drugs & Therapeutics for Hepatocellular Adenoma

Drugs for Hepatocellular Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Epinephrine Approved, Vet_approved 51-43-4 5816
2 Racepinephrine Approved 329-65-7
3 Coagulants
4 Hemostatics
5 Epinephryl borate
6 Liver Extracts

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy and Tolerability of Hemopatch After Hepatic Resection Recruiting NCT03323359

Search NIH Clinical Center for Hepatocellular Adenoma

Genetic Tests for Hepatocellular Adenoma

Anatomical Context for Hepatocellular Adenoma

MalaCards organs/tissues related to Hepatocellular Adenoma:

38
Liver, Bone Marrow, Placenta, Bone, Ovary, Testes, Pancreas

Publications for Hepatocellular Adenoma

Articles related to Hepatocellular Adenoma:

(show top 50) (show all 277)
# Title Authors Year
1
Unclassified hepatocellular adenoma in a middle-aged woman with glucose intolerance. ( 29116626 )
2018
2
Diagnostic Value of Gd-EOB-DTPA-MRI for Hepatocellular Adenoma: A Meta-Analysis. ( 28607606 )
2017
3
Systematic review: benefits and harms of transarterial embolisation for treating hepatocellular adenoma. ( 28318052 )
2017
4
Retrospective study on timing of resection of hepatocellular adenoma. ( 28857134 )
2017
5
Hepatocellular adenoma: Classification, variants and clinical relevance. ( 28131467 )
2017
6
Response to "Quantitative analysis of hepatocellular adenoma and focal nodular hyperplasia in the hepatobiliary phase: External validation of llcer method using gadobenate dimeglumine as contrast agent". ( 28580722 )
2017
7
Argininosuccinate synthase 1 (ASS1): A marker of unclassified hepatocellular adenoma and high bleeding risk. ( 28646562 )
2017
8
Malignant potential of hepatocellular adenoma. ( 28635168 )
2017
9
Laparoscopic liver resection for hemorrhagic hepatocellular adenoma in a pregnant patient. ( 28982300 )
2017
10
Short-term outcomes of laparoscopic vs. open liver resection for hepatocellular adenoma: a multicenter propensity score adjustment analysis by the AFC-HCA-2013 study group. ( 28281121 )
2017
11
Molecular classification of hepatocellular adenoma in clinical practice. ( 28733222 )
2017
12
Expression of c-MET Protein in Various Subtypes of Hepatocellular Adenoma Compared to Hepatocellular Carcinoma and Non-Neoplastic Liver in Human Tissue. ( 29256857 )
2017
13
Exome analysis of the evolutionary path of hepatocellular adenoma-carcinoma transition, vascular invasion and brain dissemination. ( 28323122 )
2017
14
Quantitative analysis Of hepatocellular adenoma and focal nodular hyperplasia in the hepatobiliary phase: External validation of LLCER method using gadobenate dimeglumine as contrast agent. ( 28589549 )
2017
15
Differentiating focal nodular hyperplasia from hepatocellular adenoma: Is hepatobiliary phase MRI (HBP-MRI) using linear gadolinium chelates always useful? ( 29110059 )
2017
16
Management and outcome of hepatocellular adenoma with massive bleeding at presentation. ( 28740346 )
2017
17
Unexpected discovery of small HNF1I+-inactivated hepatocellular adenoma in pathological specimens from patients resected for liver tumours. ( 29265678 )
2017
18
Intravoxel incoherent motion and dynamic contrast-enhanced MRI for differentiation between hepatocellular adenoma and focal nodular hyperplasia. ( 28590780 )
2017
19
Hepatocellular Carcinoma Arising in a Huge Hepatocellular Adenoma with Bone Marrow Metaplasia. ( 29281780 )
2017
20
Copper deposition in focal nodular hyperplasia and inflammatory hepatocellular adenoma. ( 29127141 )
2017
21
Correction to: Differentiating focal nodular hyperplasia from hepatocellular adenoma: Is hepatobiliary phase MRI (HBP-MRI) using linear gadolinium chelates always useful? ( 29230554 )
2017
22
Screening the key genes of hepatocellular adenoma via microarray analysis of DNA expression and methylation profiles. ( 28943905 )
2017
23
Hepatocellular adenoma with severe fatty change in a male Spontaneously Diabetic Torii rat. ( 28190927 )
2017
24
Hepatocellular adenoma in a European flatfish (Limanda limanda): Genetic alterations in laser-capture micro-dissected tissue and global transcriptomic approach. ( 28473212 )
2017
25
Men with biopsy-confirmed hepatocellular adenoma have a high risk of progression to hepatocellular carcinoma: AA nationwide population-based study. ( 28317318 )
2017
26
A cost-effectiveness analysis of the diagnostic strategies for differentiating focal nodular hyperplasia from hepatocellular adenoma. ( 28726119 )
2017
27
Inflammatory and multiple hepatocellular adenoma are associated with a higher BMI. ( 28704224 )
2017
28
Polymorphic multiple hepatocellular adenoma including a non-steatotic HNF1I+-inactivated variant. ( 28992889 )
2017
29
Touch cytology smear of an inflammatory hepatocellular adenoma displaying an unusual pattern: A case report. ( 27434199 )
2016
30
Benign hepatocellular nodules of healthy liver: focal nodular hyperplasia and hepatocellular adenoma. ( 27189732 )
2016
31
Combined use of heat-shock protein 70 and glutamine synthetase is useful in the distinction of typical hepatocellular adenoma from atypical hepatocellular neoplasms and well-differentiated hepatocellular carcinoma. ( 26769138 )
2016
32
Hepatocellular adenoma: comparison between real-time contrast-enhanced ultrasound and dynamic computed tomography. ( 27386395 )
2016
33
PET-avid hepatocellular adenomas: incidental findings associated with HNF1-I+ mutated lesions. ( 26776850 )
2016
34
Hepatocellular adenoma with malignant transformation in a patient with neonatal portal vein thrombosis. ( 27042773 )
2016
35
Evidence of good prognosis of hepatocellular adenoma in post-menopausal women. ( 27524464 )
2016
36
Hepatocellular adenoma classification: a comparative evaluation of immunohistochemistry and targeted mutational analysis. ( 26961851 )
2016
37
Distinction Between Inflammatory Hepatocellular Adenoma and Mass Effect on Liver Sampling. ( 27989788 )
2016
38
Malignant transformation of hepatocellular adenoma with bone marrow metaplasia arising in glycogen storage disease type I: A case report. ( 27900094 )
2016
39
Hepatocellular adenoma: when and how to treat? Update of current evidence. ( 27803743 )
2016
40
Molecular Classification of Hepatocellular Adenoma Associates With Risk Factors, Bleeding, and Malignant Transformation. ( 27939373 )
2016
41
European experience of 573 liver resections for hepatocellular adenoma: a cross-sectional study by the AFC-HCA-2013 study group. ( 27593592 )
2016
42
Malignant Transformation of Hepatocellular Adenoma. ( 27988517 )
2016
43
Hepatoblastoma Arising in a Pigmented I^-catenin-activated Hepatocellular Adenoma: Case Report and Review of the Literature. ( 27096257 )
2016
44
Contrast-enhanced ultrasonographic findings of serum amyloid A-positive hepatocellular neoplasm: Does hepatocellular adenoma arise in cirrhotic liver? ( 27660679 )
2016
45
Hepatocellular adenoma among adult survivors of childhood and young adult cancer. ( 27781382 )
2016
46
Correlation of exon 3 I^-catenin mutations with glutamine synthetase staining patterns in hepatocellular adenoma and hepatocellular carcinoma. ( 27469330 )
2016
47
Ultrasound features of hepatocellular adenoma and the additional value of contrast-enhanced ultrasound. ( 26818543 )
2016
48
Outcomes of liver resection for haemorrhagic hepatocellular adenoma. ( 26805568 )
2016
49
A Pigmented hepatocellular adenoma with I^-catenin activation: case report and literature review. ( 27236161 )
2016
50
Response to 'The management of hepatocellular adenoma in obese patients: issues to consider'. ( 26767571 )
2016

Variations for Hepatocellular Adenoma

Expression for Hepatocellular Adenoma

Search GEO for disease gene expression data for Hepatocellular Adenoma.

Pathways for Hepatocellular Adenoma

Pathways related to Hepatocellular Adenoma according to GeneCards Suite gene sharing:

(show all 28)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.82 ASS1 CYP1A1 CYP1A2 CYP3A4 FABP1 G6PC
2
Show member pathways
13.02 CYP1A1 CYP1A2 CYP3A4 GSTP1 UGT2B7
3
Show member pathways
12.52 CYP1A1 CYP1A2 CYP3A4 GSTP1 UGT2B7
4 12.12 ASS1 CYP1A2 CYP3A4 FABP1 GLUL HNF1A
5
Show member pathways
12.03 CYP1A1 CYP1A2 CYP3A4
6 11.89 ASS1 CTNNB1 GSTP1
7 11.89 CTNNB1 HNF1A IL6ST
8 11.85 CTNNB1 HNF1A IL6ST
9
Show member pathways
11.57 CYP1A1 CYP1A2 CYP3A4 GSTP1
10
Show member pathways
11.48 CYP1A1 CYP1A2 CYP3A4
11
Show member pathways
11.44 CYP1A1 CYP1A2 CYP3A4 UGT2B7
12
Show member pathways
11.4 CYP1A2 CYP3A4 UGT2B7
13
Show member pathways
11.37 CYP1A1 CYP1A2 CYP3A4
14
Show member pathways
11.34 CYP1A1 CYP1A2 CYP3A4 UGT2B7
15
Show member pathways
11.22 CYP3A4 UGT2B7
16 11.2 CYP1A1 CYP1A2
17 11.17 ASS1 GLUL
18 11.17 CYP1A2 CYP3A4
19
Show member pathways
11.02 ASS1 GLUL
20
Show member pathways
11.01 CYP1A2 CYP3A4
21 10.95 CYP1A2 CYP3A4
22
Show member pathways
10.9 CYP1A1 CYP1A2 CYP3A4
23 10.88 CYP3A4 UGT2B7
24
Show member pathways
10.79 CYP1A1 CYP1A2 CYP3A4 UGT2B7
25 10.72 CYP3A4 GSTP1
26 10.64 CYP1A1 CYP1A2
27 10.3 CYP1A1 CYP1A2 CYP3A4 GSTP1
28 10.19 CYP3A4 UGT2B7

GO Terms for Hepatocellular Adenoma

Cellular components related to Hepatocellular Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.8 ASS1 CTNNB1 FABP1 GLUL GSTP1 IL6ST
2 endoplasmic reticulum membrane GO:0005789 9.55 CYP1A1 CYP1A2 CYP3A4 G6PC UGT2B7
3 intracellular membrane-bounded organelle GO:0043231 9.43 CYP1A1 CYP1A2 CYP3A4 G6PC GLUL UGT2B7
4 organelle membrane GO:0031090 8.92 CYP1A1 CYP1A2 CYP3A4 UGT2B7

Biological processes related to Hepatocellular Adenoma according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 regulation of gene expression GO:0010468 9.79 CTNNB1 CYP1A2 G6PC
2 response to estradiol GO:0032355 9.73 CTNNB1 CYP1A2 GSTP1
3 xenobiotic metabolic process GO:0006805 9.69 CYP1A2 CYP3A4 GSTP1
4 glycogen metabolic process GO:0005977 9.62 G6PC IL6ST
5 response to immobilization stress GO:0035902 9.61 CYP1A1 CYP1A2
6 bone resorption GO:0045453 9.61 CTNNB1 HNF1A
7 epoxygenase P450 pathway GO:0019373 9.6 CYP1A1 CYP1A2
8 response to food GO:0032094 9.59 CYP1A1 G6PC
9 androgen metabolic process GO:0008209 9.58 CYP3A4 UGT2B7
10 cellular response to copper ion GO:0071280 9.58 CYP1A1 CYP1A2
11 exogenous drug catabolic process GO:0042738 9.57 CYP1A2 CYP3A4
12 vitamin D metabolic process GO:0042359 9.55 CYP1A1 CYP3A4
13 hydrogen peroxide biosynthetic process GO:0050665 9.54 CYP1A1 CYP1A2
14 omega-hydroxylase P450 pathway GO:0097267 9.52 CYP1A1 CYP1A2
15 oxidative demethylation GO:0070989 9.49 CYP1A2 CYP3A4
16 toxin metabolic process GO:0009404 9.48 CYP1A1 CYP1A2
17 drug catabolic process GO:0042737 9.46 CYP1A2 CYP3A4
18 monoterpenoid metabolic process GO:0016098 9.43 CYP1A2 CYP3A4
19 lipid hydroxylation GO:0002933 9.4 CYP1A1 CYP3A4
20 steroid catabolic process GO:0006706 9.37 CYP1A2 CYP3A4
21 drug metabolic process GO:0017144 9.33 CYP1A1 CYP1A2 CYP3A4
22 porphyrin-containing compound metabolic process GO:0006778 9.32 CYP1A1 CYP1A2
23 dibenzo-p-dioxin metabolic process GO:0018894 9.26 CYP1A1 CYP1A2
24 heterocycle metabolic process GO:0046483 9.13 CYP1A1 CYP1A2 CYP3A4
25 steroid metabolic process GO:0008202 9.02 CYP1A1 CYP1A2 CYP3A4 G6PC UGT2B7

Molecular functions related to Hepatocellular Adenoma according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.78 CTNNB1 CYP1A1 CYP1A2 CYP3A4
2 iron ion binding GO:0005506 9.69 CYP1A1 CYP1A2 CYP3A4
3 heme binding GO:0020037 9.67 CYP1A1 CYP1A2 CYP3A4
4 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.63 CYP1A1 CYP1A2 CYP3A4
5 monooxygenase activity GO:0004497 9.54 CYP1A1 CYP1A2 CYP3A4
6 steroid hydroxylase activity GO:0008395 9.52 CYP1A1 CYP3A4
7 estrogen 16-alpha-hydroxylase activity GO:0101020 9.43 CYP1A1 CYP3A4
8 oxygen binding GO:0019825 9.43 CYP1A1 CYP1A2 CYP3A4
9 demethylase activity GO:0032451 9.4 CYP1A1 CYP1A2
10 caffeine oxidase activity GO:0034875 9.32 CYP1A2 CYP3A4
11 vitamin D 24-hydroxylase activity GO:0070576 9.16 CYP1A1 CYP3A4
12 aromatase activity GO:0070330 9.13 CYP1A1 CYP1A2 CYP3A4
13 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 8.8 CYP1A1 CYP1A2 CYP3A4

Sources for Hepatocellular Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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