MCID: HPT067
MIFTS: 46

Hepatocellular Adenoma malady

Liver, Cancer categories

Summaries for Hepatocellular Adenoma

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Hepatocellular adenoma, also hepatic adenoma, or rarely hepadenoma, is an uncommon benign liver tumor... more...

MalaCards: Hepatocellular Adenoma is related to adenoma and familial adenomatous polyposis. An important gene associated with Hepatocellular Adenoma is HNF1A (HNF1 homeobox A), and among its related pathways are Codeine and morphine metabolism and Gefitinib Pathway, Pharmacokinetics. The compounds estrogen and fatty acid have been mentioned in the context of this disorder. Affiliated tissues include ovary, liver and uterus, and related mouse phenotypes are tumorigenesis and liver/biliary system.

Aliases & Classifications for Hepatocellular Adenoma

Sources:
49Orphanet, 61UMLS, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Liver


Characteristics (Orphanet epidemiological data):

49
hepatocellular adenoma:
Age of onset: Adulthood


Aliases & Descriptions:

hepatocellular adenoma 49 61


External Ids:

MESH via Orphanet36 D018248
ICD10 via Orphanet26 D13.4
SNOMED-CT via Orphanet58 78058005
UMLS via Orphanet62 C0206669

Related Diseases for Hepatocellular Adenoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Hepatocellular Adenoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 107)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma31.7HNF1A, FABP1, CTNNB1, G6PC, NQO1, CYP1A2
2familial adenomatous polyposis30.6CTNNB1, MMP7, GSTP1
3fatty liver disease30.0SREBF1, ABCC2, MLXIPL, FABP1
4deficiency anemia30.0IL11
5hepatitis c30.0ABCC2, CYP1A2, AFP
6pregnancy adenoma10.3
7glycogen storage disease i10.2
8amyloidosis10.2
9glycogen storage disease vi10.0
10glycogen storage disease v10.0
11bone carcinoma10.0
12beta thalassemia10.0
13polycystic ovary syndrome10.0
14hepatocellular fibrolamellar carcinoma10.0
15fetal adenoma10.0
16iron deficiency anemia10.0
17colloid adenoma10.0
18sclerosing cholangitis10.0
19hepatitis a10.0
20thalassemia10.0
21primary sclerosing cholangitis10.0
22nodular regenerative hyperplasia10.0
23hepatitis c virus10.0
24renal dysplasia10.0
25pre-eclampsia10.0AFP
26hypertriglyceridemia10.0G6PC
27leukopenia10.0IL11
28arthritis10.0IL6ST
29primary open angle glaucoma10.0CYP1B1
30germ cell cancer10.0AFP
31lung cancer10.0GSTP1
32cholestasis10.0ABCC2
33thyroid cancer10.0GSTT1
34parkinson's disease10.0COMT
35testicular cancer10.0AFP
36myeloma10.0IL11, IL6ST
37laryngeal carcinoma10.0GSTT1
38laryngeal squamous cell carcinoma10.0GSTT1
39cholangiocarcinoma10.0MMP7, AFP
40glycogen storage disease type 1a10.0SLC37A4, G6PC
41malignant glioma10.0GSTP1
42coronary heart disease10.0GSTT1, COMT
43gastritis10.0MMP7
44brain cancer10.0GSTT1, NQO1
45multiple sclerosis10.0MMP7, COMT
46pancreatic cancer10.0MMP7, NQO1, CTNNB1
47diabetes mellitus10.0HNF1A, G6PC, MLXIPL, SREBF1
48myeloid leukemia10.0IL6ST, IL11, NQO1
49infertility10.0IL11, IL6ST, GSTT1
50neutropenia10.0G6PC, CYP3A5, IL11, SLC37A4

Graphical network of the top 20 diseases related to Hepatocellular Adenoma:



Diseases related to hepatocellular adenoma

Clinical Features for Hepatocellular Adenoma

Drugs & Therapeutics for Hepatocellular Adenoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Hepatocellular Adenoma

Drug clinical trials:

Search ClinicalTrials for Hepatocellular Adenoma

Search NIH Clinical Center for Hepatocellular Adenoma

Search CenterWatch for Hepatocellular Adenoma

Genetic Tests for Hepatocellular Adenoma

Anatomical Context for Hepatocellular Adenoma

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Hepatocellular Adenoma:

33
Ovary, Liver, Uterus, Bone marrow, Thyroid, Adrenal gland, Placenta, B cells, Fetal liver, Fetal thyroid

Animal Models for Hepatocellular Adenoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Hepatocellular Adenoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.4G6PC, AFP, CYP1A2, CYP1B1, MMP7, CTNNB1
2MP:00053708.2G6PC, CTNNB1, FABP1, HNF1A, MLXIPL, NQO1
3MP:00053768.0GSTT1, COMT, FABP1, G6PC, MLXIPL, AFP

Publications for Hepatocellular Adenoma

Sources:
51PubMed
See all sources

Articles related to Hepatocellular Adenoma:

(show top 50)    (show all 201)
idTitleAuthorsYear
1
Outcomes of liver resection in hepatocellular adenoma and focal nodular hyperplasia. (23509949)
2014
2
miR-106b downregulates adenomatous polyposis coli and promotes cell proliferation in human hepatocellular carcinoma. (23087084)
2013
3
Giant hepatocellular adenoma in a child. (24075794)
2013
4
Hepatocellular carcinoma arising from hepatocellular adenoma in a hepatitis B virus-associated cirrhotic liver. (22079485)
2012
5
Characteristics and distinguishing features of hepatocellular adenoma and focal nodular hyperplasia on gadoxetate disodium-enhanced MRI. (22194486)
2012
6
Liver-specific contrast agent-enhanced magnetic resonance and A^a8,F-fluorodeoxyglucose positron emission tomography findings of hepatocellular adenoma: report of a case. (22160355)
2012
7
The management of pregnancy in women with hepatocellular adenoma: a plea for an individualized approach. (23320183)
2012
8
Hepatocellular adenoma and focal nodular hyperplasia: value of gadoxetic acid-enhanced MR imaging in differential diagnosis. (22282184)
2012
9
Co-existence of hepatocellular adenoma and focal nodular hyperplasia in a young female. (23293718)
2012
10
Pigmented hepatocellular adenoma with complete CD34 immunostaining pattern: a diagnostic dilemma. (23455796)
2012
11
Hepatocellular adenoma containing hepatocellular carcinoma in a male patient with familial adenomatous polyposis coli: Report of a case. (21922375)
2011
12
Chronic administration of ethanol leads to an increased incidence of hepatocellular adenoma by promoting H-ras-mutated cells. (21168264)
2011
13
Characterization of hepatocellular adenoma based on the phenotypic classification: The Kanazawa experience. (21883740)
2011
14
Subtype classification of hepatocellular adenoma. (20357450)
2010
15
A Hepatocellular Adenoma in a Diet-induced Obese Mouse. (22319226)
2010
16
Management of ruptured hepatocellular adenoma. (20357452)
2010
17
Hepatocellular adenoma management and phenotypic classification: the Bordeaux experience. (19585623)
2009
18
Different mechanisms of DEHP-induced hepatocellular adenoma tumorigenesis in wild-type and Ppar alpha-null mice. (18403868)
2008
19
Hepatocellular adenomas: magnetic resonance imaging features as a function of molecular pathological classification. (18688875)
2008
20
Hepatocellular adenoma: what is new in 2008. (19669260)
2008
21
Percutaneous radiofrequency ablation of hepatocellular adenoma: initial experience in 10 patients. (17944897)
2008
22
Management of a giant ruptured hepatocellular adenoma. Report of a case. (19582184)
2007
23
Hepatocellular adenoma with malignant alteration. (17523280)
2007
24
Hepatocellular adenoma subtype classification using molecular markers and immunohistochemistry. (17663417)
2007
25
Association of CYP1B1 germ line mutations with hepatocyte nuclear factor 1alpha-mutated hepatocellular adenoma. (17363580)
2007
26
Genotype phenotype classification of hepatocellular adenoma. (17569132)
2007
27
Giant hepatocellular adenoma as cause of severe abdominal pain: a case report. (17662116)
2007
28
Progression of liver pathology in patients undergoing the Fontan procedure: Chronic passive congestion, cardiac cirrhosis, hepatic adenoma, and hepatocellular carcinoma. (15942576)
2005
29
Images in hepatology. Telangiectatic adenoma: a variant of hepatocellular adenoma. (15657559)
2004
30
Telangiectatic focal nodular hyperplasia: a variant of hepatocellular adenoma. (15131793)
2004
31
Hepatocellular adenoma in a 12-year-old crossbred German shepherd dog. (15144108)
2004
32
Concomitant hepatocellular adenoma and adenomatous hyperplasia in a patient without cirrhosis. (12632534)
2003
33
Treatment of unresectable hepatocellular adenoma in dogs with transarterial iodized oil and chemotherapy with and without an embolic agent: a report of two cases. (19379180)
2003
34
Hepatocellular adenoma and polycystic ovary syndrome. (12640725)
2003
35
Focal nodular hyperplasia and hepatocellular adenoma of the liver: differentiation with multiphasic helical CT. (11373219)
2001
36
Di(2-ethylhexyl)phthalate induces hepatocellular adenoma in transgenic mice carrying a human prototype c-Ha-ras gene in a 26-week carcinogenicity study. (11560251)
2001
37
Hepatocellular adenoma of the placenta: report of a case associated with maternal bicornuate uterus and fetal renal dysplasia. (10971709)
2000
38
Hepatocellular carcinoma in children associated with Gardner syndrome or familial adenomatous polyposis. (9628444)
1998
39
Radiology case of the month. Incidental liver mass found on abdominal CT. Hepatocellular adenoma. (9677782)
1998
40
Hepatic (hepatocellular) adenoma of the placenta: a study of four cases. (9656120)
1998
41
Comparison of the proliferative capacity of adenomatous hyperplasia and well differentiated hepatocellular carcinoma. (8726829)
1996
42
Biological potential of basophilic hepatocellular foci and hepatic adenoma induced by the peroxisome proliferator, Wy-14,643. (7507413)
1994
43
Androgen receptor in cirrhotic liver, adenomatous hyperplastic nodule and hepatocellular carcinoma in the human. (1334038)
1992
44
Cell proliferative activity in adenomatous hyperplasia of the liver and small hepatocellular carcinoma. An immunohistochemical study demonstrating proliferating cell nuclear antigen. (1352480)
1992
45
Hepatocellular carcinoma coexisting with hepatic adenoma. Incidental discovery after long-term oral contraceptive use. (1663298)
1991
46
Accumulation of technetium-99m sulfur colloid by hepatocellular adenoma: scintigraphic-pathologic correlation. (3034012)
1987
47
Systemic reactive amyloidosis caused by hepatocellular adenoma. A case report. (3722793)
1986
48
Test and teach. Number forty-one. Diagnosis: hepatocellular adenoma of the liver in a patient on oral contraceptive therapy. (6316235)
1983
49
The association between oral contraception and hepatocellular adenoma--a preliminary report. (203498)
1977
50
Letter: Hepatocellular adenoma: relationship to oral contraceptives? (181604)
1976

Genetic Variations for Hepatocellular Adenoma

Expression for genes affiliated with Hepatocellular Adenoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Hepatocellular Adenoma

Search GEO for disease gene expression data for Hepatocellular Adenoma.

Pathways for genes affiliated with Hepatocellular Adenoma

Sources:
38NCBI BioSystems Database, 50PharmGKB, 54Reactome, 12EMD Millipore, 4Cell Signaling Technology, 30KEGG
See all sources

Pathways related to Hepatocellular Adenoma according to GeneCards/GeneDecks:

(show all 26)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.1ABCC2, UGT2B7
2
Hide members
10.1CYP3A5, CYP1A2
3
Hide members
10.1CYP1B1, CYP1A2
4
Hide members
10.1ABCC2, CYP3A5
510.1GSTT1, CYP1A2
6
Hide members
10.0UGT2B7, CYP1A2, CYP3A5
710.0AFP, G6PC, HNF1A
8
Hide members
9.9UGT2B7, CYP3A5, ABCC2
9
Hide members
9.9CYP1A2, CYP3A5, CYP1B1
109.9NQO1, CYP1A2, CYP1B1
11
Estrone metabolism
Hide members
9.9CYP3A5, CYP1A2, COMT
129.8GSTP1, GSTT1, CYP3A5
13
Acetaminophen metabolism
Hide members
9.8NQO1, CYP1A2, GSTP1
149.8HNF1A, FABP1, ABCC2, SREBF1
15
Retinol metabolism
Hide members
9.8UGT2B7, CYP1A2, CYP3A5, CYP1B1
16
Hide members
9.8ABCC2, CYP1B1, CYP3A5, UGT2B7
179.7SREBF1, IL6ST, CTNNB1, HNF1A
18
Naphthalene metabolism
Hide members
9.6CYP1A2, CYP1B1, GSTT1, GSTP1
199.6NQO1, ABCC2, GSTT1, GSTP1
20
Hide members
9.6COMT, G6PC, UGT2B7, CYP3A5, CYP1B1
21
Hide members
9.5COMT, UGT2B7, CYP1A2, CYP3A5, CYP1B1
22
Hide members
9.5COMT, UGT2B7, NQO1, CYP1A2, CYP1B1
23
Hide members
9.3UGT2B7, CYP1A2, CYP3A5, CYP1B1, GSTT1, GSTP1
24
Hide members
9.3ABCC2, CYP3A5, CYP1A2, NQO1, UGT2B7, COMT
25
Hide members
9.1COMT, UGT2B7, CYP1A2, CYP3A5, CYP1B1, GSTT1
26
Hide members
8.9COMT, FABP1, G6PC, UGT2B7, MLXIPL, NQO1

Compounds for genes affiliated with Hepatocellular Adenoma

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Hepatocellular Adenoma according to GeneCards/GeneDecks:

(show top 50)    (show all 215)
idCompoundScoreTop Affiliating Genes
1estrogen4510.7ABCC2
2fatty acid4510.0HNF1A, CTNNB1, MLXIPL
31-hydroxypyrene4510.0CYP1B1, GSTP1, GSTT1, NQO1
42-hydroxyestrone4510.0CYP1A2, CYP1B1, COMT
5chlorzoxazone45 29 1112.0CYP1A2, CYP3A5, CYP1B1, NQO1
6phip459.9ABCC2, CYP1B1, CYP1A2, CTNNB1
7oltipraz459.9CYP1A2, ABCC2, GSTP1, HNF1A, NQO1
8aflatoxin b145 2410.9CYP1B1, CYP3A5, CYP1A2, GSTT1
9s-phenylmercapturic acid459.9NQO1, GSTT1, GSTP1
10diclofenac45 29 50 1112.9CYP1A2, CYP3A5, UGT2B7, ABCC2, CTNNB1
11ketoconazole45 29 11 2412.9NQO1, ABCC2, CYP1B1, CYP3A5, CYP1A2
12h2o2459.8MMP7, AFP, FABP1, G6PC, CTNNB1
13hydrocarbons459.8GSTP1, GSTT1, CYP1A2, NQO1, CYP1B1
14linoleic acid45 29 2411.8FABP1, CTNNB1, CYP1A2, CYP3A5, CYP1B1, SREBF1
15daunorubicin45 50 1111.8CYP3A5, CYP1A2, NQO1, ABCC2, CYP1B1
16epoxide459.8GSTP1, GSTT1, NQO1, CYP1A2, CYP1B1
17ifosfamide45 1110.7GSTT1, AFP, IL11, CYP3A5, GSTP1
18benzo(a)pyrene459.7GSTT1, GSTP1, CYP1B1, CYP1A2, NQO1, UGT2B7
19estrone45 29 11 2412.7UGT2B7, CYP3A5, CYP1A2, CYP1B1, AFP, COMT
20glucose459.7MMP7, FABP1, MLXIPL, IL11, SREBF1, SLC37A4
21oxaliplatin45 50 1111.6NQO1, CYP1A2, CYP1B1, ABCC2, GSTP1, GSTT1
22phenobarbital45 29 1111.6CTNNB1, CYP3A5, CYP1A2, NQO1, G6PC, ABCC2
23estradiol45 11 2411.5CYP1B1, CYP3A5, CYP1A2, AFP, UGT2B7, COMT
24carbon459.5COMT, GSTP1, CYP1B1, NQO1, FABP1, AFP
25carboplatin45 50 1111.5IL11, ABCC2, GSTT1, GSTP1, AFP, NQO1
26lovastatin45 50 60 29 1113.5UGT2B7, CYP3A5, ABCC2, SREBF1, CTNNB1
27tamoxifen45 50 29 1112.5UGT2B7, CYP1A2, CYP3A5, CYP1B1, COMT, ABCC2
28paclitaxel45 50 1111.4ABCC2, GSTP1, CTNNB1, IL11, CYP1B1, AFP
29folate459.4COMT, GSTP1, GSTT1, ABCC2, NQO1, AFP
30quercetin45 60 11 2412.4COMT, CTNNB1, NQO1, CYP1A2, CYP1B1, GSTP1
31valine459.4AFP, GSTT1, ABCC2, CYP1B1, COMT, GSTP1
32cyclophosphamide45 50 1111.4GSTT1, IL11, NQO1, AFP, GSTP1, CYP1B1
335fluorouracil459.3IL11, ABCC2, CYP1B1, NQO1, AFP, CTNNB1
34arachidonic acid45 29 11 2412.3CYP1A2, SREBF1, CYP3A5, IL11, CYP1B1, AFP
35valproic acid45 50 11 2412.3CTNNB1, CYP1A2, CYP3A5, CYP1B1, UGT2B7
36epinephrine45 11 2411.3AFP, UGT2B7, CYP1A2, IL11, ABCC2, GSTP1
37creatinine459.3ABCC2, GSTT1, HNF1A, AFP, NQO1, GSTP1
38etoposide45 50 60 1112.2CYP1A2, CYP3A5, CYP1B1, IL11, GSTT1, GSTP1
39steroid459.2CYP1B1, IL11, HNF1A, GSTT1, G6PC, UGT2B7
40genistein45 29 60 2 11 2414.1IL6ST, COMT, CTNNB1, CYP1B1, ABCC2, CYP1A2
41doxorubicin45 50 1111.0MMP7, AFP, CTNNB1, NQO1, CYP1B1, IL11
42oligonucleotide458.9CTNNB1, AFP, CYP3A5, CYP1B1, IL11, GSTT1
43testosterone45 60 11 2411.9UGT2B7, GSTP1, COMT, CTNNB1, AFP, NQO1
44cisplatin45 50 60 1111.9GSTP1, ABCC2, NQO1, CTNNB1, COMT, AFP
45progesterone45 60 29 11 2412.9CTNNB1, UGT2B7, CYP1A2, CYP3A5, CYP1B1, IL11
46oxygen45 249.9NQO1, AFP, CYP1A2, G6PC, CYP1B1, IL11
47dexamethasone45 50 29 1111.8HNF1A, FABP1, CTNNB1, G6PC, AFP, NQO1
48lipid458.8CYP1B1, CYP3A5, AFP, ABCC2, MLXIPL, G6PC
49tyrosine458.5SREBF1, ABCC2, G6PC, MMP7, IL11, CYP1B1
50retinoic acid45 249.1GSTP1, COMT, HNF1A, FABP1, CTNNB1, UGT2B7

GO Terms for genes affiliated with Hepatocellular Adenoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Hepatocellular Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endoplasmic reticulum membraneGO:0057899.3SREBF1, SLC37A4, CYP1B1, CYP3A5, CYP1A2, UGT2B7

Biological processes related to Hepatocellular Adenoma according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1glucose-6-phosphate transportGO:01576010.4SLC37A4, G6PC
2drug catabolic processGO:04273710.3CYP1A2, CYP3A5
3oxidative demethylationGO:07098910.2CYP3A5, CYP1A2
4glucose homeostasisGO:04259310.1HNF1A, G6PC, MLXIPL, SLC37A4
5steroid metabolic processGO:00820210.1CYP1B1, CYP3A5, G6PC
6omega-hydroxylase P450 pathwayGO:09726710.1CYP1B1, CYP1A2
7methylationGO:03225910.0CYP1A2, COMT
8response to estradiol stimulusGO:03235510.0CTNNB1, NQO1, CYP1A2
9epoxygenase P450 pathwayGO:01937310.0CYP1A2, CYP1B1
10response to drugGO:0424939.7COMT, CTNNB1, MMP7, SREBF1, GSTT1
11response to oxidative stressGO:0069799.6ABCC2, NQO1, HNF1A
12xenobiotic metabolic processGO:0068059.3GSTP1, COMT, NQO1, CYP1A2, CYP3A5, CYP1B1
13small molecule metabolic processGO:0442818.5COMT, FABP1, G6PC, MLXIPL, NQO1, CYP1A2

Molecular functions related to Hepatocellular Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprGO:01671210.1CYP1B1, CYP1A2
2aromatase activityGO:0703309.8CYP1B1, CYP3A5, CYP1A2
3monooxygenase activityGO:0044979.6CYP1B1, CYP3A5, CYP1A2

Products for genes affiliated with Hepatocellular Adenoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hepatocellular Adenoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet