MCID: HPT067
MIFTS: 40

Hepatocellular Adenoma malady

Liver diseases, Cancer diseases categories

Summaries for Hepatocellular Adenoma

About this section
Sources:
63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 Hepatocellular adenoma, also hepatic adenoma, or rarely hepadenoma, is an uncommon benign liver tumor... more...

MalaCards: Hepatocellular Adenoma is related to adenoma and hepatocellular carcinoma. An important gene associated with Hepatocellular Adenoma is HNF1A (HNF1 homeobox A), and among its related pathways are Codeine and morphine metabolism and Gefitinib Pathway, Pharmacokinetics. The compounds estrogen and fatty acid have been mentioned in the context of this disorder. Affiliated tissues include liver, and related mouse phenotypes are tumorigenesis and liver/biliary system.

Aliases & Classifications for Hepatocellular Adenoma

About this section
Sources:
48Orphanet, 60UMLS, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Liver diseases


Characteristics (Orphanet epidemiological data):

48
hepatocellular adenoma:
Age of onset: Adulthood


Aliases & Descriptions:

hepatocellular adenoma 48 60


External Ids:

MESH via Orphanet35 D018248
ICD10 via Orphanet26 D13.4
SNOMED-CT via Orphanet57 78058005
UMLS via Orphanet61 C0206669

Related Diseases for Hepatocellular Adenoma

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Hepatocellular Adenoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 108)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma31.6HNF1A, FABP1, CTNNB1, G6PC, NQO1, CYP1A2
2hepatocellular carcinoma30.9AFP, G6PC, CTNNB1, FABP1, HNF1A, NQO1
3familial adenomatous polyposis30.5CTNNB1, MMP7, GSTP1
4hepatitis30.4COMT, AFP, CYP1A2, ABCC2, GSTT1
5obesity30.2COMT, HNF1A, FABP1, MLXIPL, CYP1A2, IL6ST
6fatty liver disease30.0SREBF1, ABCC2, MLXIPL, FABP1
7hepatitis b30.0HNF1A, AFP, CYP1A2, GSTT1
8deficiency anemia30.0IL11
9endometriosis30.0COMT, CYP1B1, IL11, MMP7, GSTT1
10glycogen storage disease10.5
11glycogen storage disease i10.3
12pregnancy adenoma10.2
13hepatitis a10.2
14amyloidosis10.2
15glycogen storage disease iv10.0
16bone carcinoma10.0
17beta thalassemia10.0
18polycystic ovary syndrome10.0
19hepatocellular fibrolamellar carcinoma10.0
20fetal adenoma10.0
21iron deficiency anemia10.0
22colloid adenoma10.0
23sclerosing cholangitis10.0
24cholangitis10.0
25chromosomal disease10.0
26in situ carcinoma10.0
27liver disease10.0
28renal adenoma10.0
29thalassemia10.0
30pre-eclampsia10.0AFP
31hypertriglyceridemia10.0G6PC
32leukopenia10.0IL11
33arthritis10.0IL6ST
34primary open angle glaucoma10.0CYP1B1
35germ cell cancer10.0AFP
36lung cancer10.0GSTP1
37cholestasis10.0ABCC2
38thyroid cancer10.0GSTT1
39parkinson's disease10.0COMT
40testicular cancer10.0AFP
41myeloma10.0IL11, IL6ST
42laryngeal benign neoplasm10.0GSTT1
43laryngeal squamous cell carcinoma10.0GSTT1
44cholangiocarcinoma10.0MMP7, AFP
45glycogen storage disease type 1a10.0SLC37A4, G6PC
46malignant glioma10.0GSTP1
47coronary heart disease10.0GSTT1, COMT
48gastritis10.0MMP7
49brain cancer10.0GSTT1, NQO1
50multiple sclerosis10.0MMP7, COMT

Graphical network of the top 20 diseases related to Hepatocellular Adenoma:



Diseases related to hepatocellular adenoma

Clinical Features for Hepatocellular Adenoma

About this section

Drugs & Therapeutics for Hepatocellular Adenoma

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Hepatocellular Adenoma

Drug clinical trials:

Search ClinicalTrials for Hepatocellular Adenoma

Search NIH Clinical Center for Hepatocellular Adenoma

Search CenterWatch for Hepatocellular Adenoma

Genetic Tests for Hepatocellular Adenoma

About this section

Anatomical Context for Hepatocellular Adenoma

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Hepatocellular Adenoma:

32
Liver

Animal Models for Hepatocellular Adenoma or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Hepatocellular Adenoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.4G6PC, AFP, CYP1A2, CYP1B1, MMP7, CTNNB1
2MP:00053708.2G6PC, CTNNB1, FABP1, HNF1A, MLXIPL, NQO1
3MP:00053768.0GSTT1, COMT, FABP1, G6PC, MLXIPL, AFP

Publications for Hepatocellular Adenoma

About this section

Genetic Variations for Hepatocellular Adenoma

About this section

Expression for genes affiliated with Hepatocellular Adenoma

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Hepatocellular Adenoma

Search GEO for disease gene expression data for Hepatocellular Adenoma.

Pathways for genes affiliated with Hepatocellular Adenoma

About this section
Sources:
37NCBI BioSystems Database, 49PharmGKB, 53Reactome, 12EMD Millipore, 4Cell Signaling Technology, 29KEGG
See all sources

Pathways related to Hepatocellular Adenoma according to GeneCards/GeneDecks:

(show all 26)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.1ABCC2, UGT2B7
2
Hide members
10.1CYP3A5, CYP1A2
3
Hide members
10.1CYP1B1, CYP1A2
4
Hide members
10.1ABCC2, CYP3A5
510.1GSTT1, CYP1A2
6
Hide members
10.0UGT2B7, CYP1A2, CYP3A5
710.0AFP, G6PC, HNF1A
8
Hide members
9.9UGT2B7, CYP3A5, ABCC2
9
Hide members
9.9CYP1A2, CYP3A5, CYP1B1
109.9NQO1, CYP1A2, CYP1B1
11
Estrone metabolism
Hide members
9.9CYP3A5, CYP1A2, COMT
129.8GSTP1, GSTT1, CYP3A5
13
Acetaminophen metabolism
Hide members
9.8NQO1, CYP1A2, GSTP1
149.8HNF1A, FABP1, ABCC2, SREBF1
15
Retinol metabolism
Hide members
9.8UGT2B7, CYP1A2, CYP3A5, CYP1B1
16
Hide members
9.8ABCC2, CYP1B1, CYP3A5, UGT2B7
179.7SREBF1, IL6ST, CTNNB1, HNF1A
18
Naphthalene metabolism
Hide members
9.6CYP1A2, CYP1B1, GSTT1, GSTP1
199.6NQO1, ABCC2, GSTT1, GSTP1
20
Hide members
9.6COMT, G6PC, UGT2B7, CYP3A5, CYP1B1
21
Hide members
9.5COMT, UGT2B7, CYP1A2, CYP3A5, CYP1B1
22
Hide members
9.5COMT, UGT2B7, NQO1, CYP1A2, CYP1B1
23
Hide members
9.3UGT2B7, CYP1A2, CYP3A5, CYP1B1, GSTT1, GSTP1
24
Hide members
9.3ABCC2, CYP3A5, CYP1A2, NQO1, UGT2B7, COMT
25
Hide members
9.1COMT, UGT2B7, CYP1A2, CYP3A5, CYP1B1, GSTT1
26
Hide members
8.9COMT, FABP1, G6PC, UGT2B7, MLXIPL, NQO1

Compounds for genes affiliated with Hepatocellular Adenoma

About this section
Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Hepatocellular Adenoma according to GeneCards/GeneDecks:

(show top 50)    (show all 215)
idCompoundScoreTop Affiliating Genes
1estrogen4410.7ABCC2
2fatty acid4410.0HNF1A, CTNNB1, MLXIPL
31-hydroxypyrene4410.0CYP1B1, GSTP1, GSTT1, NQO1
42-hydroxyestrone4410.0CYP1A2, CYP1B1, COMT
5chlorzoxazone44 28 1112.0CYP1A2, CYP3A5, CYP1B1, NQO1
6phip449.9ABCC2, CYP1B1, CYP1A2, CTNNB1
7oltipraz449.9CYP1A2, ABCC2, GSTP1, HNF1A, NQO1
8aflatoxin b144 2410.9CYP1B1, CYP3A5, CYP1A2, GSTT1
9s-phenylmercapturic acid449.9NQO1, GSTT1, GSTP1
10diclofenac44 28 49 1112.9CYP1A2, CYP3A5, UGT2B7, ABCC2, CTNNB1
11ketoconazole44 28 11 2412.9NQO1, ABCC2, CYP1B1, CYP3A5, CYP1A2
12h2o2449.8MMP7, AFP, FABP1, G6PC, CTNNB1
13hydrocarbons449.8GSTP1, GSTT1, CYP1A2, NQO1, CYP1B1
14linoleic acid44 28 2411.8FABP1, CTNNB1, CYP1A2, CYP3A5, CYP1B1, SREBF1
15daunorubicin44 49 1111.8CYP3A5, CYP1A2, NQO1, ABCC2, CYP1B1
16epoxide449.8GSTP1, GSTT1, NQO1, CYP1A2, CYP1B1
17ifosfamide44 1110.7GSTT1, AFP, IL11, CYP3A5, GSTP1
18benzo(a)pyrene449.7GSTT1, GSTP1, CYP1B1, CYP1A2, NQO1, UGT2B7
19estrone44 28 11 2412.7UGT2B7, CYP3A5, CYP1A2, CYP1B1, AFP, COMT
20glucose449.7MMP7, FABP1, MLXIPL, IL11, SREBF1, SLC37A4
21oxaliplatin44 49 1111.6NQO1, CYP1A2, CYP1B1, ABCC2, GSTP1, GSTT1
22phenobarbital44 28 1111.6CTNNB1, CYP3A5, CYP1A2, NQO1, G6PC, ABCC2
23estradiol44 11 2411.5CYP1B1, CYP3A5, CYP1A2, AFP, UGT2B7, COMT
24carbon449.5COMT, GSTP1, CYP1B1, NQO1, FABP1, AFP
25carboplatin44 49 1111.5IL11, ABCC2, GSTT1, GSTP1, AFP, NQO1
26lovastatin44 49 59 28 1113.5UGT2B7, CYP3A5, ABCC2, SREBF1, CTNNB1
27tamoxifen44 49 28 1112.5UGT2B7, CYP1A2, CYP3A5, CYP1B1, COMT, ABCC2
28paclitaxel44 49 1111.4ABCC2, GSTP1, CTNNB1, IL11, CYP1B1, AFP
29folate449.4COMT, GSTP1, GSTT1, ABCC2, NQO1, AFP
30quercetin44 59 11 2412.4COMT, CTNNB1, NQO1, CYP1A2, CYP1B1, GSTP1
31valine449.4AFP, GSTT1, ABCC2, CYP1B1, COMT, GSTP1
32cyclophosphamide44 49 1111.4GSTT1, IL11, NQO1, AFP, GSTP1, CYP1B1
335fluorouracil449.3IL11, ABCC2, CYP1B1, NQO1, AFP, CTNNB1
34arachidonic acid44 28 11 2412.3CYP1A2, SREBF1, CYP3A5, IL11, CYP1B1, AFP
35valproic acid44 49 11 2412.3CTNNB1, CYP1A2, CYP3A5, CYP1B1, UGT2B7
36epinephrine44 11 2411.3AFP, UGT2B7, CYP1A2, IL11, ABCC2, GSTP1
37creatinine449.3ABCC2, GSTT1, HNF1A, AFP, NQO1, GSTP1
38etoposide44 49 59 1112.2CYP1A2, CYP3A5, CYP1B1, IL11, GSTT1, GSTP1
39steroid449.2CYP1B1, IL11, HNF1A, GSTT1, G6PC, UGT2B7
40genistein44 28 59 2 11 2414.1IL6ST, COMT, CTNNB1, CYP1B1, ABCC2, CYP1A2
41doxorubicin44 49 1111.0MMP7, AFP, CTNNB1, NQO1, CYP1B1, IL11
42oligonucleotide448.9CTNNB1, AFP, CYP3A5, CYP1B1, IL11, GSTT1
43testosterone44 59 11 2411.9UGT2B7, GSTP1, COMT, CTNNB1, AFP, NQO1
44cisplatin44 49 59 1111.9GSTP1, ABCC2, NQO1, CTNNB1, COMT, AFP
45progesterone44 59 28 11 2412.9CTNNB1, UGT2B7, CYP1A2, CYP3A5, CYP1B1, IL11
46oxygen44 249.9NQO1, AFP, CYP1A2, G6PC, CYP1B1, IL11
47dexamethasone44 49 28 1111.8HNF1A, FABP1, CTNNB1, G6PC, AFP, NQO1
48lipid448.8CYP1B1, CYP3A5, AFP, ABCC2, MLXIPL, G6PC
49tyrosine448.5SREBF1, ABCC2, G6PC, MMP7, IL11, CYP1B1
50retinoic acid44 249.1GSTP1, COMT, HNF1A, FABP1, CTNNB1, UGT2B7

GO Terms for genes affiliated with Hepatocellular Adenoma

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Hepatocellular Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endoplasmic reticulum membraneGO:0057899.3SREBF1, SLC37A4, CYP1B1, CYP3A5, CYP1A2, UGT2B7

Biological processes related to Hepatocellular Adenoma according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1glucose-6-phosphate transportGO:01576010.4SLC37A4, G6PC
2drug catabolic processGO:04273710.3CYP1A2, CYP3A5
3oxidative demethylationGO:07098910.2CYP3A5, CYP1A2
4glucose homeostasisGO:04259310.1HNF1A, G6PC, MLXIPL, SLC37A4
5steroid metabolic processGO:00820210.1CYP1B1, CYP3A5, G6PC
6omega-hydroxylase P450 pathwayGO:09726710.1CYP1B1, CYP1A2
7methylationGO:03225910.0CYP1A2, COMT
8response to estradiol stimulusGO:03235510.0CTNNB1, NQO1, CYP1A2
9epoxygenase P450 pathwayGO:01937310.0CYP1A2, CYP1B1
10response to drugGO:0424939.7COMT, CTNNB1, MMP7, SREBF1, GSTT1
11response to oxidative stressGO:0069799.6ABCC2, NQO1, HNF1A
12xenobiotic metabolic processGO:0068059.3GSTP1, COMT, NQO1, CYP1A2, CYP3A5, CYP1B1
13small molecule metabolic processGO:0442818.5COMT, FABP1, G6PC, MLXIPL, NQO1, CYP1A2

Molecular functions related to Hepatocellular Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprGO:01671210.1CYP1B1, CYP1A2
2aromatase activityGO:0703309.8CYP1B1, CYP3A5, CYP1A2
3monooxygenase activityGO:0044979.6CYP1B1, CYP3A5, CYP1A2

Products for genes affiliated with Hepatocellular Adenoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hepatocellular Adenoma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet