Hepatocellular Cancer malady

MalaCards: Hepatocellular Cancer, also known as liver carcinoma, is related to hepatitis and viral hepatitis. An important gene associated with Hepatocellular Cancer is MAGEC2 (melanoma antigen family C, 2), and among its related pathways are Actin-Based Motility by Rho Family GTPases and Colorectal cancer. The drugs interferon alfa-2a,recombinant and interferon alfa-2a and the compounds egcg and threonine have been mentioned in the context of this disorder. Affiliated tissues include liver and b cells, and related mouse phenotypes are respiratory system and craniofacial.

OMIM: 114550

hepatocellular cancer 7 33 liver carcinoma 43

Diseases related to hepatocellular cancer by text searches and GeneDecks gene sharing:

(show top 50)    (show all 564)

id	Related Disease	Score	Top Affiliating Genes
1	hepatitis	30.6	F2, TGFB1, HGF, AFP
2	viral hepatitis	27.6	BAX, F2, TNFRSF10B, TERT, TGFB1, SOD1
3	hepatitis b	27.5	IL2RA, F2, TGFB1, AFP
4	liver cirrhosis	27.0	SERPINB3, SERPINA7, UGT1A7, MAGEC2, F2, GLUL
5	alpha 1-antitrypsin deficiency	26.8	BMP6, F2, TGFB1, AFP
6	hepatitis c	20.4	MYC, BMP6, UGT1A7, BAX, MIR21, FGF2
7	liver cancer	18.5	MYC, BMP6, BIRC5, BAX, CDKN1B, CDK4
8	hepatocellular carcinoma	15.2	SERPINB3, SERPINA7, MYC, BMP6, BIRC5, UGT1A7
9	carcinoma	14.8	SERPINB3, SERPINA7, MYC, BMP6, BIRC5, UGT1A7
10	pancreatoblastoma	13.5	APC, CTNNB1, AFP
11	gardner syndrome	13.5	APC, CTNNB1
12	desmoid disease	13.5	APC, CTNNB1
13	soft tissue neoplasm	13.4	CDK4, MDM2
14	spindle cell liposarcoma	13.4	CDK4, MDM2
15	periampullary adenocarcinoma	13.4	BAX, CDKN1B, CCND1
16	acinar cell carcinoma	13.4	APC, CTNNB1, AFP
17	sm-ahnmd	13.4	FGFR1, IL2RA, PDGFRA
18	small intestine adenocarcinoma	13.4	BAX, APC, CTNNB1
19	chondroma	13.3	CDK4, MDM2, PDGFRA
20	superficial spreading melanoma	13.3	MYC, CDK4, CCND1
21	gastroschisis	13.3	BMP6, F2, AFP
22	galactosemia	13.3	F2, GLUL, HGF, AFP
23	mature t-cell and nk-cell neoplasm	13.3	CDKN1B, PTEN
24	arteriosclerosis obliterans	13.2	MIR21, FGF2, HGF
25	creatine phosphokinase	13.2	GLUL, SOD1, AFP
26	acute liver failure	13.2	F2, GLUL, HGF, AFP
27	juvenile polyposis syndrome	13.2	APC, PTEN, CTNNB1
28	alveolar rhabdomyosarcoma	13.2	FGFR1, MDM2, CCND1, PDGFRA
29	superficial urinary bladder cancer	13.2	CCND1, TP53
30	alcoholic liver cirrhosis	13.1	HGF, AFP
31	cerebellar liponeurocytoma	13.1	APC, TP53, CTNNB1
32	craniosynostosis	13.1	BMP6, FGF2, FGFR1, PDGFRA, TGFBR2
33	desmoid tumor	13.0	CDKN1B, APC, CCND1, CTNNB1, PDGFRA
34	maxillary sinus squamous cell carcinoma	13.0	BAX, FGF2, TP53
35	pleomorphic adenoma carcinoma	13.0	CCND1, TP53, CTNNB1
36	acute lymphoblastic leukemia, childhood	13.0	BAX, CDKN1B, CDK4, MDM2
37	benign mesothelioma	13.0	CDK4, MET, TNFRSF10B, SPP1, HGF
38	colonic neoplasm	13.0	TP53, CTNNB1, HBEGF
39	embryonal sarcoma	13.0	CDK4, MDM2, TP53
40	pediatric osteosarcoma	13.0	CCND1, TP53, PDGFRA
41	drug dependence	13.0	UGT1A7, MDM2, SOD1, PENK
42	large cell medulloblastoma	13.0	MYC, MET, HGF
43	atypical teratoid rhabdoid tumor	12.9	CCND1, TP53, SPP1, CTNNB1
44	kidney cancer	12.9	FGF2, MET, SPP1, HGF
45	lynch syndrome	12.9	BAX, TP53, TGFBR2
46	hemimegalencephaly	12.9	MYC, PTEN, CTNNB1
47	cystadenocarcinoma	12.9	BIRC5, BAX, TP53, SPP1
48	follicular lymphoma	12.9	MYC, BAX, CDKN1B, CCND1
49	hematologic cancer	12.9	BIRC5, CDKN1B, FGFR1, IL2RA, SMAD2
50	retinal ischemia	12.9	BAX, FGF2, SOD1

Clinical features from OMIM: 114550

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 interferon, interferon alfa 2-b, interferon alfa-2a, interferon alfa-2a,recombinant, interferon alfa-2b,recombinant, interferon alfa-3n,human leukocyte derived, interferon alfacon-1, interferon beta-1a,recombinant, interferon beta-1b,recombinant, interferon gamma-1b, peginterferon alfa-2a, peginterferon alfa-2b

MalaCards organs/tissues related to hepatocellular cancer:

²²

MGI Mouse Phenotypes related to hepatocellular cancer:

²⁵ (show all 28)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.5	MEG3
2	craniofacial phenotype	MP:0005382	10.1	PDGFRA, ILK, SPTBN1, SULF1
3	endocrine/exocrine gland phenotype	MP:0005379	10.0	AFP, CDKN1B, FGFR1, SPTBN1
4	hematopoietic system phenotype	MP:0005397	8.5	CDK4, FGF2, MDM2, APC, CCND1, CCR7
5	liver/biliary system phenotype	MP:0005370	8.5	MEG3, MET, TP53, SPTBN1, SMAD2, EGFR
6	normal phenotype	MP:0002873	8.2	TGFBR2, PDGFRA, HBEGF, STAT3, SMAD2, SULF1
7	limbs/digits/tail phenotype	MP:0005371	8.1	MDM2, EGFR, PDGFRA, CTNNB1, SULF1, MET
8	behavior/neurological phenotype	MP:0005386	7.9	PENK, APC, MDM2, ILK, FGFR1, CDKN1B
9	reproductive system phenotype	MP:0005389	7.9	AFP, CDKN1B, FGF2, APC, CCND1, SULF1
10	immune system phenotype	MP:0005387	7.5	STAT3, ENPP2, TERT, EGFR, TP53, F2
11	renal/urinary system phenotype	MP:0005367	7.3	PDGFRA, CTNNB1, SPTBN1, SULF1, PTEN, APC
12	no phenotypic analysis	MP:0003012	7.3	MYC, CDKN1B, FGFR1, MET, ILK, APC
13	embryogenesis phenotype	MP:0005380	7.1	EGFR, MEG3, PDGFRA, CTNNB1, MYC, BIRC5
14	hearing/vestibular/ear phenotype	MP:0005377	7.1	SOD1, EGFR, CTNNB1, SPTBN1, FGFR1, FGF2
15	pigmentation phenotype	MP:0001186	7.0	MYC, CDKN1B, ILK, MDM2, APC, EGFR
16	adipose tissue phenotype	MP:0005375	6.8	EGFR, TP53, STAT3, TGFBR2, MYC, CDKN1B
17	integument phenotype	MP:0010771	6.5	HBEGF, EGFR, MYC, CDK4, F2, AIFM1
18	digestive/alimentary phenotype	MP:0005381	6.0	SMAD2, CTNNB1, SPTBN1, SULF1, PTEN, TERT
19	mortality/aging	MP:0010768	5.9	AFP, TGFBR2, HBEGF, EGFR, PDGFRA, SMAD2
20	skeleton phenotype	MP:0005390	5.4	TERT, TP53, CCND1, APC, MDM2, ILK
21	vision/eye phenotype	MP:0005391	5.0	SULF1, CTNNB1, SMAD2, TGFB1, TGFBR2, STAT3
22	tumorigenesis	MP:0002006	4.5	AFP, STAT3, TGFBR2, TGFB1, EGFR, PDGFRA
23	muscle phenotype	MP:0005369	4.2	SOD1, FGF2, CDK4, CDKN1B, BAX, MYC
24	cardiovascular system phenotype	MP:0005385	3.3	AIFM1, TP53, PTEN, SPTBN1, SPP1, CTNNB1
25	nervous system phenotype	MP:0003631	3.2	BAX, FGFR1, FGF2, CDK4, CDKN1B, MYC
26	homeostasis/metabolism phenotype	MP:0005376	3.1	AFP, PENK, SOD1, ILK, APC, ENPP2
27	growth/size phenotype	MP:0005378	2.8	CDKN1B, HGF, STAT3, TGFBR2, TGFB1, HBEGF
28	cellular phenotype	MP:0005384	2.1	EGFR, IL2RA, MET, MEG3, FGFR1, FGF2

Articles related to hepatocellular cancer:

(show all 42)

id	Title	Authors	Year	Affiliating Genes
1	microRNA-29 can regulate expression of the long non-c oding RNA gene MEG3 in hepatocellular cancer. (21625215)	Braconi C.... Patel T.	2011	MEG3, MIR29A
2	Analysis of microRNA expression profiling identifies microRNA-503 regulates metastatic function in hepatocellular cancer cell. (21495032)	Zhou J.... Wang W.	2011	MIR503
3	The opioid growth factor-opioid growth factor recepto r axis regulates cell proliferation of human hepatocellular cancer. (19923357)	Avella D.M.... Staveley-O'Carroll K.F.	2010	PENK, OGFR
4	Micro-RNA-181a regulates osteopontin-dependent metast atic function in hepatocellular cancer cell lines. (20576283)	Bhattacharya S.D.... Kuo P.C.	2010	SPP1, MIR181A2
5	Up-regulation of hTERT expression by low-dose cisplat in contributes to chemotherapy resistance in human hepatocellular cancer cells. (19639202)	Guo X.L.... Wei L.X.	2009	TERT
6	A phase II study of lapatinib in patients with advanced biliary tree and hepatocellular cancer. (19169683)	Ramanathan R.K.... Gandara D.R.	2009	EGFR
7	The STAT3 inhibitor NSC 74859 is effective in hepatocellular cancers with disrupted TGF-beta signaling. (19137011)	Lin L.... He A.R.	2009	STAT3
8	Unique phenotype of hepatocellular cancers with exon-3 mutations in beta-catenin gene. (19101982)	Cieply B.... Monga S.P.	2009	APC, CTNNB1, GLUL
9	RNA stability regulates differential expression of the metastasis protein, osteopontin, in hepatocellular cancer. (18549897)	Emani S.... Kuo P.C.	2008	SPP1
10	Silencing alpha-fetoprotein expression induces growth arrest and apoptosis in human hepatocellular cancer cell. (18657899)	Yang X.... Mao J.	2008	AFP
11	AFP, PIVKAII, GP3, SCCA-1 and follisatin as surveilla nce biomarkers for hepatocellular cancer in non-alcoholic and alcoholic fatty l iver disease. (18638391)	Beale G.... Reeves H.	2008	AFP, SERPINB3
12	Synergistic lethal effect of mDRA-6 and nimesulide on human hepatocellular cancer cell line SMMC-7721 (18423123)	Liu Y.J.... Li S.L.	2008	TNFRSF10B
13	A survivin double point mutant has potent inhibitory effect on the growth of hepatocellular cancer cells. (18296918)	Zhang R.... Yang A.G.	2008	BIRC5
14	Hepatocellular cancer arises from loss of transforming growth factor beta signaling adaptor protein embryonic liver fodrin through abnormal angiogenesis. (18704924)	Baek H.J.... Mishra L.	2008	TGFB1, SPTBN1
15	Real-time quantification of human telomerase reverse transcriptase mRNA in liver tissues from patients with hepatocellular cancer and chronic viral hepatitis. (17212643)	Satra M.... Tsezou A.	2007	TERT
16	Is autotaxin (ENPP2) the link between hepatitis C and hepatocellular cancer? (17902023)	Cooper A.B.... Maluccio M.A.	2007	ENPP2
17	Platelet-derived growth factor receptor-alpha: a novel therapeutic target in human hepatocellular cancer. (17604334)	Stock P.... Monga S.P.	2007	PDGFRA
18	MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer. (17681183)	Meng F.... Patel T.	2007	PTEN, MIR21
19	Disruption of transforming growth factor-beta signaling through beta-spectrin ELF leads to hepatocellular cancer through cyclin D1 activation. (17546056)	Kitisin K.... Mishra L.	2007	CDK4, MDM2, TGFBR2
20	Recent advances in immunotherapy for hepatocellular cancer. (17370144)	Butterfield L.H.	2007	AFP
21	Expression of integrin-linked kinase is not a useful prognostic marker in resected hepatocellular cancer. (18214046)	Intaraprasong P.... Salh B.	2007	ILK
22	Signaling pathways involved in the inhibition of epidermal growth factor receptor by erlotinib in hepatocellular cancer. (16937526)	Huether A.... Scherubl H.	2006	EGFR
23	Effect of hydroxycamptothecin on apoptosis-inducing factor (AIF) expression and on AIF translocation in human hepatocellular cancer cell SMMC-7721 (16635299)	Fu Y.R.... Yan Y.R.	2006	AIFM1
24	Chemokine receptor CCR7 enhances intrahepatic and lymphatic dissemination of human hepatocellular cancer. (16786131)	Schimanski C.C.... Moehler M.	2006	CCR7
25	Overexpression of Bax induces apoptosis and enhances drug sensitivity of hepatocellular cancer-9204 cells. (15962362)	Zheng J.Y.... Wang W.L.	2005	BAX
26	Alpha fetoprotein for screening for hepatocellular cancer in populations with viral hepatitis B: an appraisal of Thai reports. (16436007)	Wiwanitkit V.	2005	AFP
27	Predictors of survival after laparoscopic radiofrequency thermal ablation of hepatocellular cancer: a prospective study. (15759186)	Berber E.... Siperstein A.	2005	AFP
28	EGFR blockade by cetuximab alone or as combination therapy for growth control of hepatocellular cancer. (16226226)	Huether A.... Scherubl H.	2005	EGFR, CCND1, CDKN1B
29	Phase II study of Erlotinib (OSI-774) in patients with advanced hepatocellular cancer. (16170173)	Philip P.A.... Erlichman C.	2005	FGFR1
30	hSulf1 Sulfatase promotes apoptosis of hepatocellular cancer cells by decreasing heparin-binding growth factor signaling. (14699503)	Lai J.P.... Roberts L.R.	2004	HGF, FGF2, HBEGF
31	UGT1A7 polymorphisms, polycyclic aromatic hydrocarbons and the development of hepatocellular cancer. (15382168)	Kuchenbauer F.... Beuers U.	2004	UGT1A7
32	Surgical treatment of hepatocellular cancer in the era of hepatic transplantation. (12788425)	De Carlis L.... Forti D.	2003	AFP
33	Detection of mutant p53 in hepatocellular cancer from Turkey and its correlation with clinicopathologic parameters. (12772781)	Cengiz C.... Yuce G.	2003	TP53
34	Liver transplantation for hepatocellular cancer: should the current indication criteria be changed? (12595973)	De Carlis L.... Forti D.	2003	AFP
35	Expression and clinical significance of hepatocellular cancer antigen genes in human hepatocellular carcinoma (12921655)	Wang W.X.... Chen W.F.	2003	MAGEC2
36	Experimental therapy of adenovirus-transferred antis ense c-myc on hepatocellular cancer cell (11798947)	Zhang H.... Shao Y.	2001	MYC
37	Soluble interleukin-2 receptor levels in hepatocellular cancer: a more sensitive marker than alfa fetoprotein. (10082044)	Izzo F.... Curley S.A.	1999	AFP
38	Correction of both prothrombin time and primary haemostasis by recombinant factor VII during therapeutic alcohol injection of hepatocellular cancer in liver cirrhosis. (10551401)	Papatheodoridis G.V.... Burroughs A.K.	1999	F2
39	Overexpression of CuZnSOD gene suppresses the growth of hepatocellular cancer cell line HepG2. (11155667)	Bai J.... Wu Y.	1998	SOD1
40	c-met expression in human hepatocellular cancer (10374571)	Liu R.... Liu Y.	1997	MET
41	Correlation of soluble interleukin-2 receptor levels with severity of chronic hepatitis C virus liver injury and development of hepatocellular cancer. (8693411)	Izzo F.... Castello G.	1996	IL2RA
42	Thyroxine-binding globulin--not a tumor marker of hepatocellular cancer (1647573)	Sieg A.... Kommerell B.	1991	SERPINA7

Genes related to hepatocellular cancer according to GeneCards:

(show all 50)

id	Symbol	Description	Score	GeneCards Section Context
1	MAGEC2	melanoma antigen family C, 2	11.0	Publications, Aliases & Descriptions
2	WFDC1	WAP four-disulfide core domain 1	11.0	Summaries
3	MIR503	microRNA 503	10.9	Publications
4	MIR181A2	microRNA 181a-2	10.9	Publications
5	MIR29A	microRNA 29a	10.9	Publications
6	MEG3	maternally expressed 3 (non-protein coding)	10.9	Publications
7	OGFR	opioid growth factor receptor	10.9	Publications
8	PENK	proenkephalin	10.9	Publications
9	SERPINB3	serpin peptidase inhibitor, clade B (ovalbumin), member 3	10.9	Publications
10	UGT1A7	UDP glucuronosyltransferase 1 family, polypeptide A7	10.9	Publications
11	MIR21	microRNA 21	10.9	Publications
12	SERPINA7	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7	10.9	Publications
13	AFP	alpha-fetoprotein	10.9	Publications
14	ENPP2	ectonucleotide pyrophosphatase/phosphodiesterase 2	10.9	Publications
15	GLUL	glutamate-ammonia ligase	10.9	Publications
16	CCR7	chemokine (C-C motif) receptor 7	10.9	Publications
17	ILK	integrin-linked kinase	10.9	Publications
18	AIFM1	apoptosis-inducing factor, mitochondrion-associated, 1	10.9	Publications
19	SULF1	sulfatase 1	10.9	Publications
20	PDGFRL	platelet-derived growth factor receptor-like	10.9
21	HBEGF	heparin-binding EGF-like growth factor	10.9	Publications
22	TNFRSF10B	tumor necrosis factor receptor superfamily, member 10b	10.9	Publications
23	SPP1	secreted phosphoprotein 1	10.9	Publications
24	SPTBN1	spectrin, beta, non-erythrocytic 1	10.9	Publications
25	SMAD2	SMAD family member 2	10.9	Publications
26	TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	10.9	Publications
27	TERT	telomerase reverse transcriptase	10.9	Publications
28	PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	10.9	Publications
29	FGFR1	fibroblast growth factor receptor 1	10.9	Publications
30	CDK4	cyclin-dependent kinase 4	10.9	Publications
31	BAX	BCL2-associated X protein	10.9	Publications
32	CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	10.9	Publications
33	CDKN1B	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	10.9	Publications
34	F2	coagulation factor II (thrombin)	10.9	Publications
35	STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	10.9	Publications
36	APC	adenomatous polyposis coli	10.9	Publications
37	CCND1	cyclin D1	10.9	Publications
38	MET	met proto-oncogene (hepatocyte growth factor receptor)	10.9	Publications
39	BMP6	bone morphogenetic protein 6	10.9	Publications
40	BIRC5	baculoviral IAP repeat containing 5	10.9	Publications
41	SOD1	superoxide dismutase 1, soluble	10.9	Publications
42	MDM2	Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)	10.9	Publications
43	IL2RA	interleukin 2 receptor, alpha	10.9	Publications
44	MYC	v-myc myelocytomatosis viral oncogene homolog (avian)	10.9	Publications
45	HGF	hepatocyte growth factor (hepapoietin A; scatter factor)	10.9	Publications
46	FGF2	fibroblast growth factor 2 (basic)	10.9	Publications
47	PTEN	phosphatase and tensin homolog	10.9	Publications
48	TGFB1	transforming growth factor, beta 1	10.9	Publications
49	EGFR	epidermal growth factor receptor	10.9	Publications
50	TP53	tumor protein p53	10.9	Publications

Pathways related to hepatocellular cancer according to GeneDecks:

(show top 50)    (show all 130)

id	Pathway	Score	Top Affiliating Genes
1	Actin-Based Motility by Rho Family GTPases36	10.7	OGFR
2	Colorectal cancer20	10.0	TGFBR2, SMAD2, TGFB1
3	CREB Pathway36	9.6	FGFR1, PENK, BMP6, PDGFRA, OGFR, IL2RA
4	Breast Cancer Regulation by Stathmin136	9.0	PENK, EGFR, FGF2, OGFR, HGF
5	Akt Signaling36	8.7	HGF, PENK, PDGFRA, CCR7, CCND1, MDM2
6	ILK Signaling36	8.6	FGF2, FGFR1, MET, CTNNB1, ILK, PDGFRA
7	PPAR Pathway36	8.4	EGFR, MET, FGFR1, FGF2, PDGFRA, OGFR
8	p53 signaling pathway20	8.3	PTEN, TNFRSF10B, TP53, CCND1, MDM2, BAX
9	ERK Signaling36	8.2	PENK, PDGFRA, TGFB1, EGFR, MYC, BMP6
10	Signal transduction_AKT signaling41	8.2	MET, MDM2, PTEN, BAX, MYC, CDKN1B
11	Chronic myeloid leukemia20	8.1	TGFBR2, TP53, CCND1, MYC, CDKN1B, CDK4
12	Rac1 Pathway36	8.1	FGF2, BMP6, FGFR1, MET, IL2RA, OGFR
13	JNK Pathway36	8.0	IL2RA, BMP6, BAX, FGF2, FGFR1, TP53
14	Glioblastoma Multiforme36	7.9	CDKN1B, MDM2, APC, TP53, CDK4, PTEN
15	Cell cycle20	7.9	SMAD2, TP53, CCND1, MDM2, CDK4, CDKN1B
16	Endometrial cancer20	7.8	CTNNB1, EGFR, MYC, ILK, APC, CCND1
17	eIF2 Pathway36	7.7	PENK, OGFR, EGFR, PDGFRA, HGF, BMP6
18	Glioma20	7.7	CCND1, TP53, PDGFRA, EGFR, PTEN, CDK4
19	Prostate cancer20	7.7	CCND1, MDM2, TP53, PTEN, CTNNB1, FGFR1
20	ERK5 Signaling36	7.3	HGF, FGFR1, PDGFRA, IL2RA, TGFB1, OGFR
21	Telomerase Components in Cell Signaling36	7.1	FGF2, FGFR1, MET, TP53, BMP6, MYC
22	Nanog in Mammalian ESC Pluripotency36	7.1	CTNNB1, FGF2, FGFR1, MET, APC, BMP6
23	Nuclear Receptor Activation by Vitamin-A36	7.1	IL2RA, BMP6, EGFR, PDGFRA, OGFR, FGFR1
24	Activation of PKC through GPCR36	7.1	HGF, PENK, OGFR, TGFB1, PDGFRA, MET
25	Colorectal Cancer Metastasis36	7.0	CTNNB1, STAT3, TGFBR2, TGFB1, EGFR, TP53
26	DHA Signaling36	7.0	IL2RA, EGFR, HGF, TGFB1, PDGFRA, MET
27	NF-KappaB (p50-p65) Pathway36	7.0	PENK, OGFR, TGFB1, EGFR, MET, FGFR1
28	p70S6K Signaling36	7.0	PDGFRA, MET, EGFR, F2, TGFB1, OGFR
29	Renin-Angiotensin Pathway36	6.9	TGFB1, STAT3, PDGFRA, IL2RA, MET, FGFR1
30	GSK3 Signaling36	6.9	APC, PENK, HGF, PDGFRA, CTNNB1, MET
31	TGF-Beta Pathway36	6.9	TGFBR2, TNFRSF10B, IL2RA, MET, FGFR1, FGF2
32	PAK Pathway36	6.9	BAX, PENK, HGF, FGF2, FGFR1, MET
33	MAPK Family Pathway36	6.9	OGFR, BMP6, HGF, FGFR1, PENK, TGFB1
34	Melanoma20	6.8	HGF, EGFR, FGFR1, PTEN, MET, MDM2
35	IP3 Pathway36	6.8	HGF, PENK, BMP6, FGF2, FGFR1, OGFR
36	Phospholipase-C Pathway36	6.8	FGF2, HGF, PENK, OGFR, TGFB1, EGFR
37	PTEN Pathway36	6.8	OGFR, PENK, HGF, EGFR, FGF2, FGFR1
38	Antioxidant Action of Vitamin-C36	6.7	HGF, PENK, BAX, TNFRSF10B, FGFR1, MET
39	Epithelial Adherens Junctions36	6.7	TGFBR2, TGFB1, EGFR, CTNNB1, MET, FGFR1
40	Apoptotic Pathways in Synovial Fibroblasts36	6.7	BMP6, EGFR, TP53, IL2RA, MET, FGFR1
41	Tec Kinases Signaling36	6.6	HGF, IL2RA, FGF2, CCR7, PENK, BMP6
42	p38 Signaling36	6.3	FGFR1, PDGFRA, BMP6, BAX, FGF2, IL2RA
43	Cellular Apoptosis Pathway36	6.2	FGFR1, FGF2, BAX, BMP6, MET, IL2RA
44	Mitochondrial Apoptosis36	6.2	TP53, FGF2, BAX, BMP6, FGFR1, MET
45	JAK-STAT Pathway36	6.2	MYC, MET, FGF2, FGFR1, IL2RA, BAX
46	MAPK Signaling36	5.9	PDGFRA, SPP1, IL2RA, MET, FGFR1, TP53
47	p53 Mediated Apoptosis36	5.5	TP53, MDM2, IL2RA, MET, FGFR1, FGF2
48	Pancreatic Adenocarcinoma36	5.5	MET, FGFR1, MDM2, CCND1, TP53, FGF2
49	Pathways in cancer20	4.4	BAX, CTNNB1, PTEN, TP53, CCND1, MDM2
50	Molecular Mechanisms of Cancer36	4.1	HGF, PENK, TGFBR2, TGFB1, EGFR, PDGFRA

Compounds related to hepatocellular cancer according to GeneDecks:

(show top 50)    (show all 245)

id	Compound	Score	Top Affiliating Genes
1	egcg32	10.3	SOD1
2	threonine32	9.9	ILK, FGFR1, CDKN1B, SERPINA7, SPTBN1, AFP
3	h2o232	9.9	PENK, TNFRSF10B, AIFM1, GLUL, IL2RA
4	vincristine32 34 9 9	12.6	FGF2, AFP
5	bleomycin32 9 9	10.9	AFP, TGFBR2, SMAD2, CTNNB1, TP53, IL2RA
6	pge232	8.8	HGF, EGFR, SPP1, APC, FGF2
7	rapamycin32 42	9.7	EGFR, PDGFRA, TERT, AIFM1, MDM2, MET
8	estrogen32	8.6	PDGFRA, GLUL, F2, APC, ILK, SERPINA7
9	agar32	8.6	BIRC5, CDKN1B, CDK4, AFP, HBEGF, CTNNB1
10	ly29400232	8.5	CDKN1B, FGF2, STAT3, TGFB1, SMAD2, SPP1
11	sulindac32 9 9	10.2	STAT3, AIFM1, CTNNB1, BIRC5, BAX, TNFRSF10B
12	indole-3-carbinol32	7.9	STAT3, CTNNB1, PTEN, TP53, CCND1, CDK4
13	sb 20358032 42	8.7	HGF, STAT3, HBEGF, SMAD2, CTNNB1, SPP1
14	flavopiridol32 9 9	9.6	UGT1A7, BIRC5, BAX, CDKN1B, STAT3, EGFR
15	adpribose32	7.5	CCND1, MDM2, CDK4, BAX, BIRC5, AIFM1
16	matrigel32	7.5	SPP1, CCR7, CCND1, ENPP2, ILK, MET
17	adriamycin32	7.4	HGF, SOD1, CTNNB1, TERT, TNFRSF10B, TP53
18	mg 13232 42	8.3	HGF, EGFR, PTEN, TNFRSF10B, AIFM1, CCND1
19	bortezomib32 9 9	9.2	STAT3, MYC, EGFR, PTEN, TNFRSF10B, TP53
20	progesterone32 42 9 18 9	11.2	AFP, CDKN1B, BIRC5, SERPINA7, CDK4, FGFR1
21	butyrate32	7.1	AFP, TGFB1, CTNNB1, SPP1, TERT, TNFRSF10B
22	geldanamycin32 9 9	9.1	EGFR, CCND1, HGF, STAT3, CTNNB1, TP53
23	retinoic acid32 42 18	9.0	AFP, HGF, PENK, STAT3, UGT1A7, BIRC5
24	tgf beta132	6.8	CDKN1B, BMP6, HBEGF, PDGFRA, SMAD2, CTNNB1
25	gefitinib32 34 9 9	9.8	HGF, STAT3, EGFR, CTNNB1, PTEN, CCND1
26	n acetylcysteine32	6.8	CDK4, CDKN1B, BIRC5, IL2RA, CCND1, HGF
27	arsenite32 18	7.7	CCND1, MDM2, BAX, BIRC5, MYC, SOD1
28	etoposide32 42 9 9	9.6	BIRC5, BAX, CDKN1B, MDM2, TNFRSF10B, TERT
29	imatinib32 34 9 9	9.6	BIRC5, BMP6, MYC, CDKN1B, FGFR1, HGF
30	wortmannin32 42	7.6	TGFBR2, HBEGF, CTNNB1, SPP1, PTEN, TERT
31	5fluorouracil32	6.3	EGFR, CTNNB1, PTEN, TERT, TNFRSF10B, TP53
32	alanine32	6.3	AFP, HGF, TGFBR2, SERPINA7, MYC, BMP6
33	curcumin32	6.2	STAT3, TGFB1, EGFR, CTNNB1, SPP1, MYC
34	actinomycin d32	6.2	TP53, AIFM1, GLUL, MDM2, MET, FGF2
35	dexamethasone32 42 34 9 9	10.1	SMAD2, CTNNB1, SPP1, GLUL, ENPP2, MDM2
36	vegf32	6.0	CTNNB1, SPP1, TERT, TNFRSF10B, TP53, MDM2
37	phosphatidylinositol32	5.9	MDM2, ILK, IL2RA, MET, FGFR1, CDKN1B
38	doxorubicin32 34 9 9	8.9	AFP, HGF, STAT3, EGFR, CTNNB1, PTEN
39	tamoxifen32 34 9 9	8.8	STAT3, TGFBR2, TGFB1, BMP6, CDKN1B, CTNNB1
40	testosterone32 9 18 9	8.7	AFP, HGF, MET, FGFR1, CDK4, CDKN1B
41	genistein32 9 18 9	8.1	FGF2, CDK4, CDKN1B, BAX, BIRC5, MYC
42	oligonucleotide32	4.9	TGFB1, MDM2, ILK, MET, FGFR1, CDK4
43	thymidine32 18	5.8	MYC, AFP, HGF, CCND1, MDM2, IL2RA
44	pd 98,05932	4.4	HGF, PENK, STAT3, TGFB1, HBEGF, EGFR
45	cisplatin32 34 9 9	7.0	BAX, BIRC5, BMP6, MYC, TERT, TNFRSF10B
46	paclitaxel32 34 9 9	7.0	CDK4, CDKN1B, BAX, BIRC5, BMP6, MYC
47	cycloheximide32	3.7	HGF, PENK, STAT3, APC, MDM2, MET
48	paraffin32	3.7	AFP, HGF, STAT3, TGFB1, APC, MDM2
49	tyrosine32	3.3	BMP6, MYC, SERPINA7, AFP, HGF, PENK
50	serine32	2.7	F2, MYC, SERPINA7, SERPINB3, BMP6, BIRC5

Cellular components related to hepatocellular cancer according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	APC-Axin-1-beta-catenin complex	GO:034742	10.1	APC, CTNNB1
2	extracellular space	GO:005615	6.4	SERPINA7, AFP, HGF, WFDC1, SOD1, TGFB1
3	cytosol	GO:005829	6.0	AIFM1, TP53, PTEN, SPTBN1, CTNNB1, SMAD2
4	cytoplasm	GO:005737	3.7	PTEN, SPTBN1, CTNNB1, SMAD2, PDGFRA, EGFR

Biological processes related to hepatocellular cancer according to GeneDecks:

(show all 49)

id	Name	GO ID	Score	Top Affiliating Genes
1	embryonic cranial skeleton morphogenesis	GO:048701	10.2	SMAD2, TGFBR2, PDGFRA
2	positive regulation of BMP signaling pathway	GO:030513	10.2	ILK, SULF1, SMAD2
3	common-partner SMAD protein phosphorylation	GO:007182	10.2	SMAD2, SPTBN1
4	pancreas development	GO:031016	10.2	AFP, MET, SMAD2, APC
5	negative regulation of hydrogen peroxide-mediated programmed cell death	GO:1901299	10.1	MET, HGF
6	positive regulation of phospholipase C activity	GO:010863	10.1	PDGFRA, FGF2, FGFR1
7	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	GO:060665	10.1	HGF, MET, FGFR1
8	positive regulation of mesenchymal cell proliferation	GO:002053	10.0	CTNNB1, MYC, FGFR1, TGFBR2
9	gastrulation	GO:007369	10.0	SMAD2, TGFBR2, TP53
10	response to cholesterol	GO:070723	9.9	TGFBR2, TGFB1, SMAD2
11	apoptotic DNA fragmentation	GO:006309	9.9	BAX, AIFM1, SOD1, MYC
12	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	9.9	FGFR1, F2, PDGFRA, HGF
13	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO:006919	9.8	AIFM1, CDKN1B, BAX, MYC, TNFRSF10B
14	kidney development	GO:001822	9.8	SULF1, APC, BAX, BMP6
15	positive regulation of B cell apoptotic process	GO:002904	9.8	MYC, BAX
16	positive regulation of reactive oxygen species metabolic process	GO:2000379	9.8	TGFBR2, F2, TP53
17	liver development	GO:001889	9.7	AFP, CCND1, MET, HGF
18	cell aging	GO:007569	9.7	MET, ILK, SOD1, TP53
19	chromosome organization	GO:051276	9.7	APC, TP53, MYC
20	negative regulation of fibroblast proliferation	GO:048147	9.6	TP53, BAX, MYC
21	response to axon injury	GO:048678	9.6	SOD1, FGF2, BAX
22	positive regulation of phosphatidylinositol 3-kinase activity	GO:043552	9.5	FGF2, CCR7, TGFB1, PDGFRA
23	phosphatidylinositol-mediated signaling	GO:048015	9.5	PDGFRA, FGFR1, MDM2, CDKN1B, PTEN
24	organ regeneration	GO:031100	9.5	AFP, TGFB1, CCND1, HGF
25	release of cytochrome c from mitochondria	GO:001836	9.4	BAX, TP53, MYC
26	canonical Wnt receptor signaling pathway	GO:060070	9.3	CCND1, MYC, CTNNB1, PTEN, APC
27	negative regulation of transforming growth factor beta receptor signaling pathway	GO:030512	9.3	SMAD2, TGFB1, TGFBR2, TP53
28	positive regulation of fibroblast proliferation	GO:048146	9.3	MYC, EGFR, CDK4, PDGFRA
29	response to DNA damage stimulus	GO:006974	9.2	MYC, APC, CCND1, TP53, BAX
30	fibroblast growth factor receptor signaling pathway	GO:008543	9.1	PTEN, MDM2, FGFR1, FGF2, CDKN1B
31	positive regulation of MAP kinase activity	GO:043406	9.1	TGFB1, FGFR1, EGFR, ILK
32	positive regulation of protein kinase B signaling cascade	GO:051897	9.1	EGFR, ILK, CCR7, HBEGF, TGFB1
33	transforming growth factor beta receptor signaling pathway	GO:007179	9.0	MYC, TGFBR2, TGFB1, SMAD2, TP53
34	in utero embryonic development	GO:001701	9.0	SMAD2, TGFBR2, FGFR1, TP53, CTNNB1
35	negative regulation of cell growth	GO:030308	8.9	CDKN1B, FGF2, TP53, WFDC1, TGFB1
36	cell surface receptor signaling pathway	GO:007166	8.9	F2, EGFR, TNFRSF10B, MET, IL2RA
37	positive regulation of cell migration	GO:030335	8.8	PDGFRA, EGFR, HBEGF, TGFB1, ILK, APC
38	cell cycle arrest	GO:007050	8.8	CDKN1B, TGFB1, MYC, ILK, APC, TP53
39	MAPK cascade	GO:000165	8.8	FGFR1, MYC, EGFR, TGFB1
40	positive regulation of epithelial cell proliferation	GO:050679	8.8	TGFB1, EGFR, MYC, BMP6
41	epidermal growth factor receptor signaling pathway	GO:007173	8.3	EGFR, MDM2, PTEN, TGFB1, CDKN1B, HBEGF
42	positive regulation of transcription, DNA-dependent	GO:045893	8.1	MYC, ILK, TP53, CTNNB1, SMAD2, TGFB1
43	negative regulation of transcription, DNA-dependent	GO:045892	8.1	BIRC5, CDKN1B, FGF2, MDM2, TP53, CTNNB1
44	response to drug	GO:042493	8.0	CCND1, WFDC1, SERPINA7, SOD1, CTNNB1, STAT3
45	negative regulation of cell proliferation	GO:008285	8.0	PTEN, TP53, TGFB1, SMAD2, CTNNB1, APC
46	cell proliferation	GO:008283	8.0	STAT3, TP53, PTEN, EGFR, IL2RA, GLUL
47	apoptotic process	GO:006915	7.8	FGF2, APC, CTNNB1, TGFBR2, IL2RA, SULF1
48	negative regulation of apoptotic process	GO:043066	7.8	PTEN, TP53, APC, MDM2, FGFR1, CDKN1B
49	positive regulation of cell proliferation	GO:008284	6.3	PDGFRA, CDKN1B, CDK4, FGF2, FGFR1, ILK

Molecular functions related to hepatocellular cancer according to GeneDecks:

(show all 8)

id	Name	GO ID	Score	Top Affiliating Genes
1	transcription factor binding	GO:008134	8.8	STAT3, SMAD2, CTNNB1, TP53, ENPP2, MYC
2	protein homodimerization activity	GO:042803	8.5	TGFB1, PDGFRA, TERT, FGFR1, BAX, UGT1A7
3	growth factor activity	GO:008083	8.4	FGF2, F2, HBEGF, TGFB1, HGF, BMP6
4	protein kinase binding	GO:019901	8.3	TP53, PTEN, ILK, STAT3, CCND1, APC
5	identical protein binding	GO:042802	8.1	EGFR, TP53, MDM2, FGFR1, BAX, BIRC5
6	enzyme binding	GO:019899	7.0	BIRC5, UGT1A7, CCND1, TGFB1, EGFR, CTNNB1
7	protein heterodimerization activity	GO:046982	6.8	HGF, UGT1A7, BAX, MET, TP53, TGFB1
8	protein binding	GO:005515	2.6	PDGFRA, HGF, SOD1, MET, STAT3, TGFBR2