Search MalaCards:
HCC
MCID: HPT023

Hepatocellular Carcinoma malady
16 drugs, 2031 genes, 32 tissues, 1645 related diseases, 29 phenotypes, 4233 articles, clinical trials.

Summaries for Hepatocellular Carcinoma

about this section
Sources:
17Genetics Home Reference, 44Wikipedia, 22MalaCards
See all sources

Export this MalaCard
Genetics Home Reference: Hypomyelination and congenital cataract is an inherited condition that affects the nervous system and the eyes. This disease is one of a group of genetic disorders called leukoencephalopathies. Leukoencephalopathies involve abnormalities of the brain's white matter. White matter consists of nerve fibers covered by a fatty substance called myelin. Myelin insulates nerve fibers and promotes the rapid transmission of nerve impulses. Hypomyelination and congenital cataract is caused by a reduced ability to form myelin (hypomyelination). Additionally, people with this disorder are typically born with a clouding of the lens (cataract) in both eyes.17

MalaCards: Hepatocellular Carcinoma, also known as adult primary hepatocellular carcinoma, is related to carcinoma and prostatitis. An important gene associated with Hepatocellular Carcinoma is FGL1 (fibrinogen-like 1), and among its related pathways are Rho Family GTPases and Pancreatic Adenocarcinoma. The drugs carmustine and diethylstilbestrol diphosphate and the compounds calcium and dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, lymph node and spleen, and related mouse phenotypes are homeostasis/metabolism and mortality/aging.

Wikipedia: Hepatocellular carcinoma (HCC, also called malignant hepatoma) is the most common type of liver cancer....44 more...

Aliases & Descriptions for Hepatocellular Carcinoma

about this section
Sources:
6Disease Ontology, 7diseasecard, 8DISEASES, 33OMIM, 32Novoseek , 43UMLS, 27NCIt, 24MeSH
See all sources

Aliases & Descriptions:

hepatocellular carcinoma 6 7 8 33 32
adult primary hepatocellular carcinoma 6 43
liver carcinoma 6 43
hepatocellular carcinoma (morphologic abnormality) 6
carcinoma of liver, specified as primary 6
hepatocellular carcinoma of the mouse 43
primary carcinoma of liver (disorder) 6
primary carcinoma of the liver cells 6
hepatocellular carcinoma (clinical) 6
adult primary liver carcinoma 6
primary carcinoma 43
adult hepatoma 6
carcinoma 43
hepatoma 6
hcc 6

External Ids:

Related Diseases for Hepatocellular Carcinoma

about this section
Sources:
13GeneCards, 14GeneDecks
See all sources

Disease types for hepatocellular carcinoma family:

hepatocellular carcinoma (fibrolamellar variant)

Diseases related to hepatocellular carcinoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1641)
idRelated DiseaseScoreTop Affiliating Genes
1carcinoma508.4ZNF148, ZNF384, ZNF689, ZNF592, PIGR, PIK3CB
2prostatitis302.0PIK3CB, PIK3CD, PIM2, PIK3CA, PIK3R1, PIK3CG
3leukemia280.6ZNF384, PIK3CB, PIK3CD, PIM2, PIK3CA, PIK3R1
4pancreatitis271.7ZNF148, PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIM3
5adenocarcinoma263.3ZNF148, PIGR, PIK3CB, PIM2, PIK3CA, PIK3R1
6neuronitis253.2ZNF148, ZNF384, PIK3CB, PIK3CD, PI4K2A, PIK3CA
7melanoma239.7PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, KL
8gastric cancer227.7ZNF148, PIK3CB, PIK3CA, PIK3R1, PIK3CG, PIN1
9ovarian cancer220.7PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, KLF6
10thyroiditis215.2PIK3CB, PIK3CA, PIK3R1, PIK3CG, PIN1, NCAM1
11colon cancer202.1PIK3CB, PIK3CA, PIK3R1, PIM3, PIK3CG, KLF6
12esophagitis197.5PIK3CB, PIK3CA, PIK3CG, PIN1, KLF6, NCAM1
13cervicitis187.6ZNF384, PIK3CA, PIK3CG, PIN1, KL, NCL
14breast carcinoma186.7PIK3CA, PIK3R1, PIK3CG, NCL, NCOA3, RECK
15hypoxia182.3PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, PDCD4
16neuroblastoma173.3PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, PIN1
17arthritis169.3PIK3CD, PIK3CG, PIN1, KL, PDCD1, PDCD1LG2
18ovarian carcinoma168.3PIK3CA, PIK3CG, NCOA3, PDCD4, RECK, RELA
19sarcoma165.4ZNF384, PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG
20adenoma161.8PIK3CA, PIM3, NCAM1, NCOA3, PDCD4, RECK
21lung carcinoma160.7PIK3CA, PIK3R1, PIK3CG, KLF6, NCAM1, RECK
22fibrosis160.0PIK3CA, PIK3CG, PIN1, KL, KLF6, NCOA3
23rheumatoid arthritis154.1PIK3CD, PIK3CG, PIN1, KL, PDCD1, PDCD1LG2
24myeloma153.4PIM2, PIK3CA, PIK3R1, PIK3CG, NCAM1, RECK
25alzheimer's disease152.2PIK3CB, PIK3CD, PI4K2A, PIK3CA, PIK3R1, PIK3CG
26myeloid leukemia150.1PIK3CB, PIK3CD, PIM2, PIK3CA, PIK3R1, PIK3CG
27cholesterol149.7PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, KL
28cervical cancer141.6PIK3CA, PIK3CG, PIN1, NCL, NCR3, PDCD1
29malaria137.4PIM2, PIM3, WDR16, RFC4, NCL, NCR3
30colon carcinoma135.2PIGR, PIK3CB, PIK3CA, PIK3R1, PIK3CG, KL
31oral squamous cell carcinoma133.5PIK3CA, PIN1, PDCD1, PDCD1LG2, PDCD4, RECK
32retinitis131.2PIK3CA, PIK3CG, KLF6, REV3L, CNR1, CNR2
33esophageal squamous cell carcinoma130.5PIK3CA, PIN1, NCAM1, NCOA3, RECK, RELA
34cerebritis129.3PIK3R1, PIK3CG, KLF6, NCAM1, REG1A, RELA
35osteosarcoma127.0PIK3CB, PIK3CA, PIK3CG, RECK, RELA, REV3L
36multiple myeloma125.8PIK3CA, PIK3R1, PIK3CG, NCAM1, RECK, RELA
37lymphocytic leukemia125.2PIK3CD, PIM2, PIK3CA, PIK3CG, NCAM1, NCL
38tuberculosis124.2PIM2, PIK3CG, PDCD1, PDCD1LG2, RELA, RELB
39diabetes mellitus122.1PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, PDCD1
40ischemia121.1PIK3CA, PIK3CG, NCAM1, RELA, CNR1, CNR2
41cholangiocarcinoma118.0PIK3CA, PIK3CG, NCAM1, PDCD4, RECK, KIT
42hypertension117.6PIK3CB, PIK3R1, PIK3CG, KL, KLF6, NCAM1
43obesity117.2PIK3CB, PIK3CA, PIK3R1, PIK3CG, NCOA3, NCR3
44nasopharyngitis116.9PIGR, PIK3CA, PIK3CG, KLF6, NCOA3, PDCD1
45asthma116.0PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, PIN1
46astrocytoma115.5PIK3CA, PIK3R1, PIK3CG, KLF6, NCAM1, RECK
47endometrial cancer114.5PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, NCOA3
48acute myeloid leukemia114.3PIK3CB, PIK3CD, PIM2, PIK3CA, PIK3R1, PIK3CG
49endometrial carcinoma114.2PIK3CB, PIK3CA, PIK3CG, NCOA3, RELA, CNR2
50retinoblastoma110.8PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, KLF6

Graphical network of the top 20 diseases related to hepatocellular carcinoma:



Graphical network of diseases related to hepatocellular carcinoma

Clinical Features for Hepatocellular Carcinoma

about this section

Drugs & Therapeutics for Hepatocellular Carcinoma

about this section
Sources:
4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
See all sources

Approved drugs:

Search CenterWatch for hepatocellular carcinoma

Drug clinical trials:

Search ClinicalTrials for hepatocellular carcinoma

Search NIH Clinical Center for hepatocellular carcinoma

Search CenterWatch for hepatocellular carcinoma

Inferred drug relations via UMLS/NDF-RT:

43 28 carmustine, diethylstilbestrol, diethylstilbestrol diphosphate, interferon, interferon alfa 2-b, interferon alfa-2a, interferon alfa-2a,recombinant, interferon alfa-2b,recombinant, interferon alfa-3n,human leukocyte derived, interferon alfacon-1, interferon beta-1a,recombinant, interferon beta-1b,recombinant, interferon gamma-1b, nilutamide, peginterferon alfa-2a, peginterferon alfa-2b

Genetic Tests for Hepatocellular Carcinoma

about this section

Anatomical Context for Hepatocellular Carcinoma

about this section
Sources:
22MalaCards
See all sources

MalaCards organs/tissues related to hepatocellular carcinoma:

22
Bone marrow, Lymph node, Spleen, Brain, Smooth muscle, Skeletal muscle, Small intestine, Colon, Kidney, Liver, Lung, Pancreas, Thyroid, Breast, Skin, Placenta, Prostate, Testis, Myeloid, Monocytes, Nk cells, T cells, B cells, Endothelial, Fetal brain, Caudate nucleus, Cardiac myocytes, Fetal liver, Fetal lung, Fetal thyroid, Pituitary, Testis germ

Phenotypes for genes affiliated with Hepatocellular Carcinoma

about this section
Sources:
25MGI
See all sources

MGI Mouse Phenotypes related to hepatocellular carcinoma:

25 (show all 29)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1homeostasis/metabolism phenotypeMP:0005376136.4ZNF148, PIGR, PIK3CB, PIK3CD, PI4K2A, PIK3CA
2mortality/agingMP:0010768128.1ZNF148, PIK3CB, PI4K2A, PIK3CA, PINX1, KL
3cellular phenotypeMP:0005384125.1ZNF148, PIK3CB, PIK3CD, PIM2, PIK3CA, PIK3R1
4growth/size phenotypeMP:0005378113.8ZNF148, ZNF384, PIK3CB, PI4K2A, PIM2, PIK3CA
5cardiovascular system phenotypeMP:000538595.6ZNF148, PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG
6immune system phenotypeMP:000538782.4ZNF148, PIGR, PIK3CD, PIM2, PIM3, KL
7nervous system phenotypeMP:000363177.4ZNF148, PI4K2A, KL, PDCD1, RECK, RELA
8behavior/neurological phenotypeMP:000538669.8PI4K2A, PIK3CA, KL, NCAM1, NCOA3, RELB
9hematopoietic system phenotypeMP:000539768.2PIGR, PIM2, PIM3, PINX1, KLF6, RFWD2
10normal phenotypeMP:000287364.4ZNF148, PI4K2A, PIK3R1, PIM3, PDCD6, RELA
11tumorigenesisMP:000200662.8PIK3CB, PIK3CA, PIK3R1, PINX1, RFWD2, NCOA3
12reproductive system phenotypeMP:000538962.1ZNF148, ZNF384, PIGR, PI4K2A, PIK3CA, KLF6
13integument phenotypeMP:001077160.4ZNF148, PIK3CG, PIN1, PINX1, KL, KLF6
14muscle phenotypeMP:000536959.6PIK3CA, PIK3R1, PIK3CG, KL, NCOA3, PDCD1
15digestive/alimentary phenotypeMP:000538159.3ZNF148, PIGR, KL, NCOA3, RELB, RELN
16embryogenesis phenotypeMP:000538058.8ZNF148, PIK3CB, PIK3CA, PINX1, KLF6, KLF8
17vision/eye phenotypeMP:000539154.6PIK3CA, PIN1, NCAM1, PDCD1, RELA, RELN
18skeleton phenotypeMP:000539054.5ZNF384, PIK3CD, PIK3CG, RECK, RELA, CNN1
19renal/urinary system phenotypeMP:000536746.5PI4K2A, KL, NCOA3, PDCD1, PDCD4, RET
20no phenotypic analysisMP:000301238.9PIK3CD, PIK3R1, RFWD2, PDCD1LG2, RET, CNR1
21liver/biliary system phenotypeMP:000537038.7KLF6, NCOA3, RECK, RELB, WASF2, KIT
22limbs/digits/tail phenotypeMP:000537136.5KL, RECK, RELA, RELB, RET, CNN1
23craniofacial phenotypeMP:000538232.5NCOA3, REV3L, KIT, VPS54, LMNB1, BMI1
24adipose tissue phenotypeMP:000537531.0PIK3CA, PIK3R1, KL, NCOA3, CNR1, SFRP1
25endocrine/exocrine gland phenotypeMP:000537930.7ZNF148, ZNF384, KL, RFWD2, PDCD4, REG1A
26hearing/vestibular/ear phenotypeMP:000537730.2NCOA3, KIT, RB1, RBP1, VDR, LMNA
27respiratory system phenotypeMP:000538823.4KL, RELB, RET, KIF1B, SFRP4, RBPJ
28other phenotypeMP:000539522.2KL, RECK, RELB, CNR1, VPS35, BUB1
29pigmentation phenotypeMP:000118621.9RFWD2, KIT, BTD, RB1, RBPJ, RBP1

Publications for genes affiliated with Hepatocellular Carcinoma

about this section
Sources:
35PubMed
See all sources

Articles related to hepatocellular carcinoma:

(show top 50)    (show all 4233)
idTitleAuthorsYearAffiliating Genes
1Expression and clinicopathologic significance of GPC 3 and other antibodies in well-differentiated hepatocellular carcinoma]. (21429352)Du J.L.... Wang Y.L.2011GPC3
2Gene expression profiling of fixed tissues identified hypoxia-inducible factor-1I+, VEGF, and matrix metalloproteinase-2 as biomarker s of lymph node metastasis in hepatocellular carcinoma. (21712445)Xiang Z.L.... Gao D.M.2011MMP2, VEGFA, HIF1A
3MicroRNA-99a inhibits hepatocellular carcinoma growth and correlates with prognosis of patients with hepatocellular carcinoma. (21878637)Li D.... Cao X.2011MIR99A
4Inhibition of c-FLIP expression by miR-512-3p contrib utes to taxol-induced apoptosis in hepatocellular carcinoma cells. (20372864)Chen F.... Chen Z.2010CFLAR, MIR512-1, MIR512-2
5Fibrolamellar hepatocellular carcinoma: an immunohist ochemical comparison with conventional hepatocellular carcinoma. (20444731)Abdul-Al H.M.... Goodman Z.D.2010BIRC5, UQCC
6Strategy and mechanism for the prevention of hepatocellular carcinoma: phosphorylated retinoid X receptor alpha is a critical target for hepatocellular carcinoma chemoprevention. (19068086)Shimizu M.... Moriwaki H.2009RXRA, NR1H2
7Reduced expression of C/EBP alpha protein in hepatocellular carcinoma is associated with advanced tumor stage and shortened patient survival. (18663475)Tseng H.H.... Yu H.S.2009CEBPA
8ING1a and ING1b different expressed in sporadic hepatocellular carcinoma. (18450387)Chen X.... Zhu T.2009ING1
9Lack of somatic mutations in VEGFR-2 tyrosine kinase domain in hepatocellular carcinoma. (19160077)Chuah B.Y.... Lee S.C.2009KDR
10Alpha-fetoprotein response after locoregional therapy for hepatocellular carcinoma: oncologic marker of radiologic response, progres sion, and survival. (19805671)Riaz A.... Salem R.2009AFP
11Expression of Src and FAK in hepatocellular carcinoma and the effect of Src inhibitors on hepatocellular carcinoma in vitro. (18979199)Lau G.M.... Fang J.W.2009SRC, PTK2
12Cellular retinaldehyde-binding protein-like (CRALBPL), a novel human Sec14p-like gene that is upregulated in human hepatocellular carcinomas, may be used as a marker for human hepatocellular carcinomas. (18271718)Zhao S.... Mao Y.2008NF1, CLVS1
13Circulating and hepatic Fas expression in HCV-induced chronic liver disease and hepatocellular carcinoma. (18679533)El Bassiouny A.E.... Ibrahim R.A.2008FAS
14Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice. (18318442)Martinez-Chantar M.L.... Mato J.M.2008GNMT
15Activation of B-Myb by E2F1 in hepatocellular carcinoma. (18624722)Nakajima T.... Okanoue T.2008E2F1, MYBL2
16Significance of serum hepatocyte growth factor levels in patients with hepatocellular carcinoma undergoing hepatic resection. (17218078)Chau G.Y.... Wu C.W.2008HGF
17Protein kinase C delta regulates the phosphorylation of heat shock protein 27 in human hepatocellular carcinoma. (17673262)Takai S.... Kozawa O.2007PRKCD, HSPB1, DYT10
18Proteomic identification of down-regulation of oncoprotein DJ-1 and proteasome activator subunit 1 in hepatitis B virus-infected well-differentiated hepatocellular carcinoma. (17671684)Zhang D.... Koay E.S.2007PARK7, PSME1
19Proteome analysis of hepatocellular carcinoma by two-dimensional difference gel electrophoresis: novel protein markers in hepatocellular carcinoma tissues. (17627933)Sun W.... He F.2007FTCD, HNRNPC
20Comparison of the expression of agrin, a basement membrane heparan sulfate proteoglycan, in cholangiocarcinoma and hepatocellular carcinoma. (17640714)Batmunkh E.... Kovalszky I.2007AGRN
21Mutations of the tumor suppressor Kruppel-like factor 6 (KLF6) gene in hepatocellular carcinoma and its effect of growth suppression on human hepatocellular carcinoma cell line HepG2 (16494780)Pan X.C.... Yang Z.G.2006KLF6
22Agrin, a novel basement membrane component in human and rat liver, accumulates in cirrhosis and hepatocellular carcinoma. (16983329)Tatrai P.... Kovalszky I.2006AGRN
23Opposite roles of human pancreatitis-associated protein and REG1A expression in hepatocellular carcinoma: association of pancreatitis-associated protein expression with low-stage hepatocellular carcinoma, beta-catenin mutation, and favorable prognosis. (15814635)Yuan R.H.... Hsu H.C.2005CTNNB1, REG3A
24PIK3CA gene is frequently mutated in breast carcinomas and hepatocellular carcinomas. (15608678)Lee J.W.... Lee S.H.2005PIK3CA, AGK
25Expression profiling in hepatocellular carcinoma with intrahepatic metastasis: identification of high-mobility group I(Y) protein as a molecular marker of hepatocellular carcinoma metastasis. (15247513)Chuma M.... Sakamoto M.2004HMGA1
26Midkine protects hepatocellular carcinoma cells against TRAIL-mediated apoptosis through down-regulation of caspase-3 activity. (15160348)Ohuchida T.... Itoh H.2004CASP3, CASP8, TNFSF10
27Two variants of the human hepatocellular carcinoma-associated HCAP1 gene and their effect on the growth of the human liver cancer cell line Hep3B. (14603441)Wan D.... Gu J.2004GEMIN4
28Ultrasound guided fine needle biopsy of early hepatocellular carcinoma complicating liver cirrhosis: a multicentre study. (15306600)Caturelli E.... de Sio I.2004AFP
29Newer markers for hepatocellular carcinoma. (15508074)Marrero J.A.... Lok A.S.2004AFP
30Overexpression of squamous cell carcinoma antigen variants in hepatocellular carcinoma. (14970861)Pontisso P.... Fassina G.2004SERPINB3, SERPINB4
31Differentially expressed genes between solitary large hepatocellular carcinoma and nodular hepatocellular carcinoma. (15534908)Yang L.Y.... Huang G.W.2004CDHR2
32Evaluation of antioxidant status in patients with primary hepatocellular carcinoma (14648972)Czeczot H.... Porembska Z.2003SOD1, CAT
33Laminin and its alpha 6 integrin receptor in the regulation of human hepatocellular carcinoma cell phenotypes (12678983)Lu T.J.... Zhou R.L.2003ITGA6
34S-phase delay in human hepatocellular carcinoma cells induced by overexpression of integrin beta1. (12918102)Liang Y.L.... Zha X.L.2003AKT1, ITGB1, CDKN1B
35Epitope of somatic mutations in the hepatocyte growth factor receptor naturally processed and presented by HLA-A2 on human hepatocellular carcinoma (11798848)Guo A.... Ye J.2001MET
36Increased expression of transforming growth factor-alpha in a patient with recurrent hepatocellular carcinoma following partial hepatectomy. (11827422)Sohda T.... Sakisaka S.2001TGFA
37Expression of cyclin D1, cyclin E, cdk4 and loss of heterozygosity of 8p, 13q, 17p in hepatocellular carcinoma: comparison study of childhood and adult hepatocellular carcinoma. (10847487)Kim H.... Jang J.J.2000CDK4, CCND1
38Expression of MAGE-1 gene in hepatocellular carcinoma (10488416)Liu B.... He P.1999MAGEA1
39Development of hepatocellular carcinoma in a patient with chronic hepatitis C after 6 years of a sustained and complete response to IFN-alpha. (10478890)Yamaguchi K.... Kohno S.1999IFNA1
40Expression of alpha-fetoprotein and albumin genes in human hepatocellular carcinomas: limitations in the application of the genes for targeting human hepatocellular carcinoma in gene therapy. (9462663)Ohguchi S.... Tsuji T.1998ALB, AFP
41Activation of the beta-catenin gene in primary hepatocellular carcinomas by somatic alterations involving exon 3. (9635572)Miyoshi Y.... Nakamura Y.1998CTNNB1
42In vivo gene therapy for alpha-fetoprotein-producing hepatocellular carcinoma by adenovirus-mediated transfer of cytosine deaminase gene. (9012474)Kanai F.... Omata M.1997AFP
43The expression of mdm2 gene related to the invasiveness of human hepatocellular carcinoma (11038752)Qiu S.... Wu Z.1997MDM2
44Detection of a unique gamma-glutamyl transpeptidase messenger RNA species closely related to the development of hepatocellular carcinoma in humans: a new candidate for early diagnosis of hepatocellular carcinoma. (8621139)Tsutsumi M.... Taniguchi N.1996GGT1
45Hepatitis B- and hepatitis C-associated hepatocellular carcinoma: evaluation of alpha-fetoprotein as a diagnostic marker. (8703246)Songsivilai S.... Senawong S.1995AFP
46Expression of functional receptors for human C5a anaphylatoxin (CD88) on the human hepatocellular carcinoma cell line HepG2. Stimulation of acute-phase protein-specific mRNA and protein synthesis by human C5a anaphylatoxin. (7541417)Buchner R.R.... Morgan E.L.1995SERPINA3, C5AR1
47Point mutations of the P53 gene, human hepatocellular carcinoma and aflatoxins. (8301066)Gerbes A.L.... Caselmann W.H.1993TP53
48p53 mutations and aflatoxin B1 exposure in hepatocellular carcinoma patients from Thailand. (8380058)Hollstein M.C.... Montesano R.1993TP53
49Expression in human hepatocellular carcinoma of nucleoside diphosphate kinase, a homologue of the nm23 gene product. (1322996)Nakayama T.... Nagataki S.1992NME1
50Expression of transforming growth factor-beta 1 mRNA in human hepatocellular carcinoma. (1703520)Ito N.... Tarui S.1990TGFB1

Expression for genes affiliated with Hepatocellular Carcinoma

about this section
Sources:
1BioGPS
See all sources
Expression patterns in normal tissues for genes affiliated with Hepatocellular Carcinoma

Pathways for genes affiliated with Hepatocellular Carcinoma

about this section
Sources:
36QIAGEN, 20KEGG, 41Thomson Reuters, 10EMD Millipore, 37R&D Systems
See all sources

Pathways related to hepatocellular carcinoma according to GeneDecks:

(show top 50)    (show all 337)
idPathwayScoreTop Affiliating Genes
1Rho Family GTPases3634.7PIK3R1, KIT, BTC, VIM, VEGFB, VEGFC
2Pancreatic Adenocarcinoma3631.7PIK3R1, KIT, BTC, RB1, BRAF, BRCA2
3Estrogen Pathway3627.1PIK3R1, NCOA3, KIT, BTC, BRAF, VEGFB
4p70S6K Signaling3625.7PIK3R1, KIT, BTC, VEGFB, VEGFC, BMP6
5Transendothelial Migration of Leukocytes3625.0PIK3R1, VCAM1, MYH1, BMX, RASSF5, RAC1
614-3-3 Induced Intracellular Signaling3624.1PIK3R1, BTC, VEGFB, VEGFC, BMP7, BMP8A
7Paxillin Interactions3623.9PIK3R1, KIT, BTC, VEGFB, VEGFC, VCL
8STAT3 Pathway3623.4BRAF, MYC, BMP6, BMP7, RAF1, RAC1
9Influenza A2023.1PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, RELA
10Nuclear Receptor Activation by Vitamin-A3622.9NCOA3, KIT, BTC, RBP5, VEGFB, VEGFC
11Rap1 Pathway3622.8BTC, BRAF, VEGFB, VEGFC, BMP6, BMP7
12Glucocorticoid Receptor Signaling3621.2NCOA3, BMP6, BMP7, BCL2, BAX, CEBPB
13Measles2020.9PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, RELA
14Tuberculosis2020.4RELA, VDR, RAF1, RAB5A, RAB7A, BID
15Chemokine signaling pathway2020.2PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, RELA
16Hepatitis C2020.2PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, RELA
17PEDF Induced Signaling3620.1RELA, SERPINF1, BRAF, BMP6, BMP7, RAF1
18Apoptosis2018.4PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, RELA
1914-3-3 Induced Apoptosis3616.9PIK3R1, BID, BCL2, CHUK, YWHAB, YWHAE
20RAR-Gamma-RXR-Alpha Degradation3616.5RBP5, BMP7, RARG, UBD, UBC, CD80
21Amoebiasis2016.4PIK3CB, PIK3CD, PIK3CA, PIK3R1, RELA, SERPINB3
22Insulin Receptor Pathway3616.3PIK3R1, BRAF, RAF1, YWHAB, YWHAE, YWHAG
23Development_HGF signaling pathway4116.2PIK3CB, PIK3CD, PIK3CA, PIK3R1, RAF1, RAC1
24Signal transduction PTEN pathway1016.2PIK3CB, PIK3CD, PIK3CA, PIK3R1, PCNA, RAF1
25Apoptosis through Death Receptors3616.2BID, BCL2, CHUK, BAX, CFLAR, APAF1
26IL-2 Pathway3616.1PIK3R1, MYC, RAF1, CHUK, JUN, JAK1
27TREM1 Pathway3616.0PIK3R1, BRAF, RAF1, BID, CHUK, BAD
28TRAF Pathway3615.8PIK3R1, CHUK, UBD, UBC, JUN, FOS
29HIF1Alpha Pathway3615.5VHL, VEGFB, VEGFC, LDHA, UBD, UBC
30Pertussis2015.5RELA, SERPING1, CFL1, JUN, CD14, ITGA5
31Apoptosis and survival_TNFR1 signaling pathway4115.4RELA, RELB, BRE, BID, BCL2, CHUK
32Development_A2A receptor signaling4115.4PIK3CB, PIK3CD, PIK3CA, RELA, RELB, BRAF
33Adipocytokine signaling pathway2015.4RELA, PCK2, LEP, LEPR, CHUK, MTOR
34IL-3 Pathway3615.2PIK3R1, BRAF, RAF1, BCL2L1, CHUK, YWHAB
35Immune response_IL-9 signaling pathway4115.1PIK3CB, PIK3CD, PIK3CA, PIK3R1, RELA, RAF1
36ErbB Family Pathway3615.1PIK3R1, BTC, BRAF, RAF1, PAK1, PAK4
37Development Flt3 signaling1014.9PIK3CB, PIK3CD, PIK3CA, PIK3R1, RAF1, RAC1
38Development_Neurotrophin family signaling4114.9PIK3CB, PIK3CD, PIK3CA, PIK3R1, BRAF, RAF1
39Immune response_IL-6 signaling pathway4114.7RELA, RELB, RAF1, CEBPB, JUN, JUND
40Adipocytokines & Insulin Signaling3714.7PIK3CB, PIK3CD, PIK3R1, PIK3CG, RBP4, BRAF
41Cell adhesion PLAU signaling1014.6PIK3CB, PIK3CD, PIK3CA, PIK3R1, NCL, VTN
42Immune response_Oncostatin M signaling via MAPK in human cells4114.5RAF1, RAC1, LIFR, LDLR, CEBPB, ATF2
43Translation _Regulation of EIF4F activity4114.3PIK3CB, PIK3CA, PIK3R1, RAC1, PAK1, MTOR
44Development_Growth hormone signaling via PI3K/AKT and MAPK cascades4114.3PIK3R1, CEBPB, ATF2, JUN, JUNB, JAK2
45Development A2A receptor signaling1014.2PIK3CB, PIK3CD, PIK3CA, RELA, RELB, BRAF
46Malaria2014.2SELE, SELP, VCAM1, SDC1, CD36, CD81
47Immune response IL-9 signaling pathway1014.1PIK3CB, PIK3CD, RELA, RAF1, BCL3, CISH
48ErbB2-ErbB3 Heterodimers3613.8PIK3R1, RAF1, BAD, FOXO3, GSK3B, GRB2
49Apoptosis and survival Role of CDK5 in neuronal death and survival1012.1BCL2, BAD, APAF1, CASP9, AKT3, ERBB3
50Translation Regulation activity of EIF4F1011.2PIK3CB, PIK3CD, PAK1, MAPK12, AKT2, AKT3

Compounds for genes affiliated with Hepatocellular Carcinoma

about this section
Sources:
32Novoseek , 9DrugBank, 18HMDB, 42Tocris Bioscience, 34PharmGKB
See all sources

Compounds related to hepatocellular carcinoma according to GeneDecks:

(show top 50)    (show all 465)
idCompoundScoreTop Affiliating Genes
1calcium32 9 18 9 95.2PIGR, PIK3CD, PIN1, KL, NCL, PDCD6
2dexamethasone32 42 34 9 9 75.0PIK3CA, PIK3R1, NCAM1, VWF, VTN, PCK2
3atp32 66.3PIK3CB, PIK3CA, RFC4, NCAM1, NCL, RECK
4cholesterol32 9 18 9 57.4PIK3CB, PIK3CA, PIK3R1, RECK, RELN, CNR2
5progesterone32 42 9 18 9 55.1PIK3CA, PIK3R1, NCAM1, NCOA3, KIT, KISS1
6paclitaxel32 34 9 9 48.5PIK3CA, PIK3CG, PIN1, NCL, KIT, PCNA
7glucose32 41.7REG3A, KIT, KISS1, BTC, BTD, SETD2
8heparin32 9 18 9 41.3PIK3CA, PIK3CG, NCAM1, NCL, RECK, VWF
9forskolin32 42 9 9 38.9PIK3R1, CNR2, VIM, VIP, VIPR1, BRAF
10hydrogen32 18 36.9PIN1, CNR2, KIR3DL1, RBP1, SERPINB2, RAD51
11vitamin d32 35.0NCOA3, SERPINE1, VIM, VDR, BMP6, BMP7
12ribonucleic acid32 33.1KLF6, RET, KIT, RBP4, SERPINA7, SERPINA6
13polyacrylamide32 27.1NCL, RECK, RB1, RBP4, SERPINA7, SERPINA6
14camptothecin32 42 9 9 29.4PIK3CG, NCL, PCNA, RB1, SETD2, BRCA2
15norepinephrine32 9 18 9 29.1CNR1, VWF, SELE, SELP, VIP, VCAM1
16cytochalasin d32 42 25.4PIK3CG, VWF, VTN, SELE, VIM, VCAM1
17potassium32 9 18 9 27.1PIK3CA, NCAM1, KIR3DL1, VTN, SERPINF1, VIP
18magnesium32 9 18 9 26.5RECQL, RBP4, RAD51, RAB5A, RAC1, PAK1
19histidine32 22.0SERPINA7, VHL, RAD51, RARA, SCT, LGALS1
20sucrose32 9 18 9 24.9RECK, RBP4, BSG, VCL, RAD51, RARA
21simvastatin32 34 42 9 18 9 26.6VWF, RBP4, SELE, SELP, SERPINE1, VEGFA
22irinotecan32 34 9 9 24.1KIT, BRAF, VEGFA, PARP1, BCL2L1, UMPS
23pdtc32 20.7PIK3CA, PIK3CG, GCLC, SELE, SETD2, SERPINB5
24ornithine32 18 20.1PCK2, RBP4, SERPINB2, MYC, RARA, CLU
25ionomycin32 18.6PIK3CB, SETD2, SERPINA3, LMNB1, BCL10, CHUK
26vitamin-e32 18.6RBP4, SERPINB2, LPA, VCAM1, RARA, BIRC5
27thalidomide32 42 9 9 21.4VTN, VEGFA, BIRC5, KDR, BCL2L1, CHUK
28sodium dodecylsulfate32 18.3VWF, VTN, SERPINA7, SERPINE1, LPA, MYC
29atorvastatin32 34 9 18 9 22.3VWF, SELE, SELP, VEGFA, LPA, VCAM1
30hydroxyurea32 9 9 20.3NCL, KIT, PCNA, BRCA2, VCAM1, MYC
31silymarin32 17.7PCNA, VEGFA, BMP6, BIRC5, PARP1, CHUK
32cytosine32 18 18.4RELN, SERPINB5, SERPINB2, RAD51, RASSF1, LCP1
33procollagen32 17.2PCNA, VIM, BMP6, LGALS1, P4HB, CD36
34dithiothreitol32 16.6VWF, SERPINB2, SEPP1, VKORC1, NAT1, LPA
35crcs32 16.6PIK3CA, RB1, BRAF, RASSF1, BIRC5, MUC1
36losartan32 34 9 9 19.4VWF, PCNA, SELE, SELP, SERPINE1, VCAM1
37hydroxyproline32 18 17.1BMP6, PARK2, P4HA2, P4HB, CD36, ITGB1
38palmitate32 15.9SELE, SCP2, LDLR, UCP2, S100A6, XBP1
39melphalan32 9 9 17.9GCLC, RAD51, BIRC5, BCL2L1, BCL2L11, CHKB
40peroxynitrite32 15.5SERPINA1, SEPP1, NAT1, PARP1, CHKB, MPO
41phosphoenolpyruvate32 9 9 17.4PCK2, BLZF1, CEBPB, ATF2, FOXM1, FOXO1
42gsts32 15.3KIT, NAT1, NAT2, MVP, MTHFR, XRCC1
43tbhq32 15.0GCLC, UGT1A, UGT1A6, JUN, JUND, FOS
44poly(i-c)32 14.8VCAM1, CHUK, MX1, CD69, IRF1, IRF3
45neopterin32 14.8PAH, LGALS3BP, CHKB, MX1, SAA4, B2M
46ifosfamide32 9 9 16.7B2M, CGA, MGMT, GSTM1, GSTP1, GSTT1
47leupeptin32 14.6PIGR, VWF, VIP, CD4, MME, IGFBP3
48vitamin b1232 14.1VWF, PCNA, SERPINA3, LPA, BHMT, MTRR
49il 1032 13.6VDR, BMP6, CD8A, CD40, IL10, IL15
50levonorgestrel32 9 9 14.6SERPINC1, SERPINA7, SERPINA6, FUCA1, MMP1, MMP3

GO Terms for genes affiliated with Hepatocellular Carcinoma

about this section
Sources:
12Gene Ontology
See all sources

Cellular components related to hepatocellular carcinoma according to GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1nucleusGO:005634113.1ZNF148, ZNF384, ZNF689, ZNF592, PIK3CB, PIN1
2cytoplasmGO:005737108.5PIM3, PIK3CG, PIN1, PINX1, WDR16, KLF6
3cytosolGO:00582990.3PIK3CB, PIK3CD, PI4K2A, PIK3CA, PIK3R1, PIK3CG
4plasma membraneGO:00588676.8PIK3CD, PIK3R1, PIK3CG, KL, NCAM1, PDCD1
5extracellular regionGO:00557651.6PIGR, KL, NCAM1, PDCD1LG2, REG1A, CNDP1
6nucleoplasmGO:00565448.4PIN1, RFC4, RFWD2, NCOA3, RELA, PCBP2
7extracellular spaceGO:00561544.7KL, REG3A, RELN, KIT, VTN, SFRP1
8integral to plasma membraneGO:00588743.4PIGR, PI4K2A, KL, NCR3, RET, SGCE
9nucleolusGO:00573042.1ZNF148, ZNF384, PINX1, RFWD2, NCL, NCOA3
10mitochondrionGO:00573933.8PI4K2A, PINX1, KIF1B, KIAA0101, PCK2, GCSH
11cell surfaceGO:00998627.2NCAM1, KISS1R, SFRP1, SFRP4, VEGFA, VCAM1
12perinuclear region of cytoplasmGO:04847126.0BUB1B, SELE, SET, LMNA, RAD51, CLU
13external side of plasma membraneGO:00989718.4NCAM1, KIT, VWF, SELP, VCAM1, KDR
14extracellular matrixGO:03101217.1VWF, VTN, SFRP1, SFRP2, SERPINF1, SERPINE1
15membrane raftGO:04512116.9PI4K2A, SELE, BSG, RAB5A, BCL10, JAK2
16melanosomeGO:04247015.9SERPINF1, BSG, RAB27A, RAB5A, RAC1, RAB7A
17platelet alpha granule lumenGO:03109314.5VWF, SERPINA1, SERPINE1, SERPING1, VEGFA, VEGFB

Biological processes related to hepatocellular carcinoma according to GeneDecks:

(show top 50)    (show all 89)
idNameGO IDScoreTop Affiliating Genes
1signal transductionGO:00716542.7PIK3CB, PIK3CD, PDCD1, RET, KIT, SFRP5
2apoptotic processGO:00691540.9PIM3, PDCD1, PDCD4, KIF1B, SFRP5, BUB1
3positive regulation of transcription from RNA polymerase II promoterGO:04594435.4ZNF148, KLF6, NCOA3, RELA, SFRP2, RB1
4gene expressionGO:01046732.0PCBP2, RBPJ, SET, SERPINE1, VDR, MYC
5positive regulation of transcription, DNA-dependentGO:04589331.8PIM2, KLF6, NCOA3, RELA, RET, SFRP1
6blood coagulationGO:00759631.7PIK3CB, PIK3CA, PIK3R1, PIK3CG, VWF, SELP
7negative regulation of transcription from RNA polymerase II promoterGO:00012231.4ZNF148, RBPJ, VHL, VDR, MYC, BMI1
8negative regulation of apoptotic processGO:04306630.0PIM3, PIK3CG, RELA, SFRP1, BTC, BTG2
9response to drugGO:04249328.6SFRP1, SFRP2, SERPINA7, VEGFC, MYC, PARK7
10virus-host interactionGO:01904827.7PIK3R1, RELA, BUB1, BTRC, RB1, VIM
11cell proliferationGO:00828326.6PIM2, REG3A, PCNA, BUB1, BUB1B, SERPINF1
12cell adhesionGO:00715525.5NCAM1, RELN, VWF, VTN, BYSL, SELP
13negative regulation of transcription, DNA-dependentGO:04589225.3ZNF148, PDCD4, RELA, SFRP1, SFRP2, GCLC
14anti-apoptosisGO:00691625.1PIM2, PIK3CA, RELA, GCLC, SERPINB2, BRAF
15angiogenesisGO:00152523.2PIK3CA, PIK3CG, NCL, WASF2, SETD2, SERPINE1
16mitotic cell cycleGO:00027822.9RFC4, PCNA, BUB1, BUB1B, BUB3, BTRC
17platelet activationGO:03016822.2PIK3CB, PIK3CA, PIK3R1, PIK3CG, VWF, SELP
18cell-cell signalingGO:00726722.2SFRP2, S100A9, XCL1, CGA, CEACAM6, CD86
19positive regulation of apoptotic processGO:04306521.6CNR1, SFRP1, SFRP2, SFRP4, RARG, RARB
20nerve growth factor receptor signaling pathwayGO:04801121.5PIK3CB, PIK3CA, PIK3R1, RELA, BRAF, RAF1
21transcription initiation from RNA polymerase II promoterGO:00636720.5RBPJ, SERPINE1, VDR, MYC, RARG, RARA
22cytokine-mediated signaling pathwayGO:01922120.0PIN1, KLF6, NCAM1, RELA, KIT, VCAM1
23induction of apoptosisGO:00691719.9BNIP3L, BNIPL, BCL10, BCL2L11, MX1, BBC3
24G1/S transition of mitotic cell cycleGO:00008219.6PIM2, PCNA, RB1, BCL2, CKS1B, UBC
25xenobiotic metabolic processGO:00680519.4CNDP2, GCLC, NAT1, NAT2, PAPSS1, UGT1A1
26cell cycle arrestGO:00705018.9RB1, MYC, RASSF1, SART1, MSH2, CDK6
27response to organic cyclic compoundGO:01407018.9SFRP1, BTG2, SELP, SERPINA1, LEF1, UGT1A1
28transforming growth factor beta receptor signaling pathwayGO:00717918.7SERPINE1, MYC, PARP1, PARD3, UCHL5, UBC
29response to lipopolysaccharideGO:03249618.2CNR1, CNR2, SELE, SELP, SERPINA1, UGT1A1
30response to estradiol stimulusGO:03235518.0SFRP4, SERPINA1, BRCA2, VDR, RARA, BID
31activation of cysteine-type endopeptidase activity involved in apoptotic processGO:00691917.9PDCD6, VCP, MYC, BCL2L11, BBC3, BAD
32agingGO:00756817.8KL, CNR1, SERPINA7, SERPINF1, VDR, VCAM1
33positive regulation of gene expressionGO:01062817.6NCOA3, RELB, KIT, SFRP4, BRAF, VEGFA
34epidermal growth factor receptor signaling pathwayGO:00717317.4PIK3CA, PIK3R1, RAF1, BCAR1, CHUK, YWHAB
35platelet degranulationGO:00257616.9VWF, SELP, SERPINA1, SERPINE1, SERPING1, VEGFA
36activation of MAPK activityGO:00018716.7PIK3CB, KIT, UBC, FRS2, CD81, CD74
37induction of apoptosis by intracellular signalsGO:00862916.4MYC, BMF, BID, CLU, BCL2, BCL2L1
38phosphatidylinositol-mediated signalingGO:04801516.4PIK3CB, PIK3CA, PIK3R1, RFC4, PCNA, BUB1B
39toll-like receptor 4 signaling pathwayGO:03414216.3RELA, CHUK, UBC, S100A14, ATF1, ATF2
40Toll signaling pathwayGO:00806316.2RELA, CHUK, UBC, ATF1, ATF2, JUN
41response to ethanolGO:04547116.2CNR1, RBP4, BCL2, BAK1, S100A8, S100A9
42response to woundingGO:00961116.0VWF, RAC1, FN1, FGF7, MET, MDK
43leukocyte migrationGO:05090016.0PIK3CB, PIK3CA, PIK3R1, SELP, BSG, YES1
44toll-like receptor 3 signaling pathwayGO:03413815.9RELA, CHUK, UBC, ATF1, ATF2, JUN
45TRIF-dependent toll-like receptor signaling pathwayGO:03566615.9RELA, CHUK, UBC, ATF1, ATF2, JUN
46response to glucocorticoid stimulusGO:05138415.8SFRP4, PCK2, SERPINF1, SERPINE1, UCN, CEBPA
47MyD88-independent toll-like receptor signaling pathwayGO:00275615.6RELA, CHUK, UBC, ATF1, ATF2, JUN
48positive regulation of NF-kappaB transcription factor activityGO:05109215.3RELA, CLU, BCL10, CHUK, UBC, MTDH
49positive regulation of peptidyl-tyrosine phosphorylationGO:05073114.6RELN, VTN, VEGFA, VEGFB, MTOR, JAK2
50MAPK cascadeGO:00016514.3RET, MYC, RAF1, PAK1, YWHAB, CDK1

Molecular functions related to hepatocellular carcinoma according to GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:005515159.5ZNF148, PIK3CB, PIK3CD, PI4K2A, PIK3CA, PIK3R1
2ATP bindingGO:00552446.5PIK3CB, PIK3CD, PI4K2A, PIM2, PIK3CA, PIM3
3sequence-specific DNA binding transcription factor activityGO:00370033.9ZNF148, KLF6, RELA, RELB, RB1, RBPJ
4protein homodimerization activityGO:04280331.2PDCD6, KIT, VWF, RCHY1, VEGFA, VEGFB
5sequence-specific DNA bindingGO:04356526.8ZNF148, VDR, MYC, RARG, RARA, RARB
6protein kinase bindingGO:01990124.5RELA, VIM, PAK1, PARK2, BCAR1, BCL10
7identical protein bindingGO:04280223.5RELA, SFRP1, PCNA, VIM, VCP, BNIP3L
8protein heterodimerization activityGO:04698223.2BRAF, VEGFA, VEGFB, BNIP3L, MYC, BMP6
9transcription factor bindingGO:00813422.4RELA, RB1, VHL, MYC, RARA, PARP1
10receptor bindingGO:00510221.7RCHY1, SERPINE1, VCP, RARA, RARRES2, SCP2
11enzyme bindingGO:01989920.8PCBP2, GCSH, SERPINB12, VHL, RARA, RAC1
12growth factor activityGO:00808320.1REG1A, BTC, VEGFA, VEGFB, VEGFC, BMP6
13transcription regulatory region DNA bindingGO:04421219.2RELA, MZF1, ZFHX3, KDM1A, LEF1, CIITA
14double-stranded DNA bindingGO:00369016.1ZNF148, KLF6, MYC, RAD51, RAD51AP1, YBX1
15heme bindingGO:02003716.0SDHC, MPO, JAK2, FLVCR2, FADS2, IDO1

Sources for Hepatocellular Carcinoma

about this section
2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
Browse MalaCards: 1-9 | A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z