HCC
MCID: HPT023
MIFTS: 89

Hepatocellular Carcinoma (HCC) malady

Liver diseases, Cancer diseases categories

Summaries for Hepatocellular Carcinoma

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Sources:
8Disease Ontology, 33MedlinePlus, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Your liver is the largest organ inside your body. it helps your body digest food, store energy, and remove poisons. primary liver cancer starts in the liver. metastatic liver cancer starts somewhere else and spreads to your liver. risk factors for primary liver cancer include having hepatitis b or c heavy alcohol use having cirrhosis, or scarring of the liver having hemochromatosis, an iron storage disease obesity and diabetes symptoms can include a lump or pain on the right side of your abdomen and yellowing of the skin. however, you may not have symptoms until the cancer is advanced. this makes it harder to treat. doctors use tests that examine the liver and the blood diagnose liver cancer. treatment options include surgery, radiation, chemotherapy, or liver transplantation. nih: national cancer institute

MalaCards: Hepatocellular Carcinoma, also known as liver cancer, is related to hepatoblastoma and melanoma. An important gene associated with Hepatocellular Carcinoma is TP53 (tumor protein p53), and among its related pathways are Pathways in cancer and Endometrial cancer. The drugs mechlorethamine and irinotecan and the compounds actinomycin d and gefitinib have been mentioned in the context of this disorder. Affiliated tissues include the liver, liver and endothelial.

Disease Ontology:8 A gastrointestinal system cancer that is located in the liver.

Wikipedia:63 Hepatocellular carcinoma (HCC, also called malignant hepatoma) is the most common type of liver cancer.... more...

Description from OMIM:46 114550

Aliases & Classifications for Hepatocellular Carcinoma

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Sources:
8Disease Ontology, 46OMIM, 10DISEASES, 44Novoseek, 42NIH Rare Diseases, 60UMLS, 33MedlinePlus, 22GTR, 48Orphanet, 39NCIt, 34MeSH, 56SNOMED-CT, 26ICD10 via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Liver diseases


Aliases & Descriptions:

hepatocellular carcinoma 8 46 10 44
liver cancer 8 42 33
adult primary hepatocellular carcinoma 8 60
primary malignant neoplasm of liver 8 60
malignant hepato-biliary neoplasm 8 60
hepatocellular cancer 42 22
liver carcinoma 8 60
liver neoplasm 8 10
hepatic cancer 8 44
hepatoma 8 42
hcc 8 42
epithelial hepatic and intrahepatic bile duct neoplasm 8
malignant neoplasm of liver, not specified as primary 8
non-resectable primary hepatic malignant neoplasm 8
liver and intrahepatic biliary tract carcinoma 60
resectable malignant neoplasm of the liver 8
carcinoma of liver, specified as primary 8
primary malignant neoplasm of liver nos 8
malignant neoplasm of liver unspecified 8
resectable malignant neoplasm of liver 8
hepatocellular carcinoma of the mouse 60
primary carcinoma of the liver cells 8
malignant neoplasm of liver, primary 8
hepatocellular carcinoma, adult 42
adult hepatocellular carcinoma 48
adult primary liver carcinoma 8
malignant neoplasm of liver 8
primary carcinoma of liver 8
malignant tumor of liver 8
primary liver cancer 8
neoplasm metastasis 60
ca liver - primary 8
neoplasm of liver 8
hepatic neoplasm 8
liver neoplasms 60
hepatocarcinoma 42
adult hepatoma 8
secondary 8


Related Diseases for Hepatocellular Carcinoma

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Hepatocellular Carcinoma:



Diseases related to hepatocellular carcinoma

Clinical Features for Hepatocellular Carcinoma

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Sources:
46OMIM
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Clinical features from OMIM:

114550

Drugs & Therapeutics for Hepatocellular Carcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Hepatocellular Carcinoma

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Sources:
22GTR
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Genetic tests related to Hepatocellular Carcinoma:

id Genetic test Affiliating Genes
1 Hepatocellular Carcinoma22

Anatomical Context for Hepatocellular Carcinoma

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Hepatocellular Carcinoma:

32
Liver, Endothelial, T cells, Testes, Skin, Colon, Lung, Bone, Testis, Thyroid, Monocytes, Breast, Lymph node, Smooth muscle, B cells, Spleen, Prostate, Kidney, Bone marrow, Fetal liver, Myeloid, Placenta, Pancreas, Pituitary, Ovary, Skeletal muscle, Adrenal gland, Brain, Appendix

FMA organs/tissues related to Hepatocellular Carcinoma:

14
The liver

Animal Models for Hepatocellular Carcinoma or affiliated genes

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Publications for Hepatocellular Carcinoma

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Sources:
50PubMed
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Articles related to Hepatocellular Carcinoma:

(show top 50)    (show all 6532)
idTitleAuthorsYear
1
Hepatocellular carcinoma: illustrated guide to systematic radiologic diagnosis and staging according to guidelines of the american association for the study of liver diseases. (24428297)
2014
2
Low expression of the putative tumour suppressor spinophilin is associated with higher proliferative activity and poor prognosis in patients with hepatocellular carcinoma. (23591196)
2013
3
MicroRNA-657 promotes tumorigenesis in hepatocellular carcinoma by targeting transducin-like enhancer protein 1 through nuclear factor kappa B pathways. (23175432)
2013
4
Dysfunctional activation of neurotensin/IL-8 pathway in hepatocellular carcinoma is associated with increased inflammatory response in microenvironment, more epithelial mesenchymal transition in cancer and worse prognosis in patients. (23418512)
2013
5
Synchronous development of intrahepatic cholangiocarcinoma and hepatocellular carcinoma in different sites of the liver with chronic B-viral hepatitis: two case reports. (24313990)
2013
6
Chronic liver diseases and hepatocellular carcinoma: an update for 2013. (24281012)
2013
7
Notch1 activation contributes to tumor cell growth and proliferation in human hepatocellular carcinoma HepG2 and SMMC7721 cells. (22922832)
2012
8
Hepatocellular carcinoma as unusual cause for paraplegia. (22965954)
2012
9
Expression features of SOX9 associate with tumor progression and poor prognosis of hepatocellular carcinoma. (22515642)
2012
10
IGFBP7 downregulation is associated with tumor progression and clinical outcome in hepatocellular carcinoma. (21328580)
2012
11
DNA binding protein A expression and methylation status in hepatocellular carcinoma and the adjacent tissue. (22159460)
2012
12
Involvement of discoidin domain 1 receptor in recurrence of hepatocellular carcinoma by genome-wide analysis. (22752569)
2012
13
HIWI is associated with prognosis in patients with hepatocellular carcinoma after curative resection. (21989785)
2012
14
The clinical relevance of the expression of the ratio of laminin-5 subchains messenger RNA of hepatocellular carcinoma to non-cancerous liver remnant: a prospective study. (21940345)
2011
15
Cyclophilin A promotes human hepatocellular carcinoma cell metastasis via regulation of MMP3 and MMP9. (21667159)
2011
16
Effects of the knockdown of hypoxia inducible factor-1I+ expression by adenovirus-mediated shRNA on angiogenesis and tumor growth in hepatocellular carcinoma cell lines. (20924210)
2010
17
Hypoxia and retinoic acid-inducible NDRG1 expression is responsible for doxorubicin and retinoic acid resistance in hepatocellular carcinoma cells. (20573444)
2010
18
Evaluation of the role of hexokinase type II in cellular proliferation and apoptosis using human hepatocellular carcinoma cell lines. (19690031)
2009
19
Overexpression of EphA2, MMP-9, and MVD-CD34 in hepatocellular carcinoma: Implications for tumor progression and prognosis. (19788698)
2009
20
Genetic polymorphisms in the cytokine genes and risk of hepatocellular carcinoma in low-risk non-Asians of USA. (19126646)
2009
21
Prostaglandin E2 receptors and COX enzymes in human hepatocellular carcinoma: role in the regulation of cell growth. (19250221)
2009
22
Cucurbitacin D isolated from Trichosanthes kirilowii induces apoptosis in human hepatocellular carcinoma cells in vitro. (19185617)
2009
23
Predeposit autologous plasma donation in liver resection for hepatocellular carcinoma: toward allogenic blood-free operations. (19632597)
2009
24
Clinical challenges and images in GI. Diagnosis: Hepatic angiomyolipoma mimicking hepatocellular carcinoma. (19254682)
2009
25
Epigallocatechin gallate induces apoptosis in human hepatocellular carcinoma HepG2 cells via TGF/Smad signaling pathway]. (20021857)
2009
26
Impairment of clathrin-mediated endocytosis via cytoskeletal change by epithelial to fibroblastoid conversion in HepG2 cells: a possible mechanism of des-gamma-carboxy prothrombin production in hepatocellular carcinoma. (19020747)
2008
27
Des-gamma-carboxyprothrombin, alpha-fetoprotein and AFP-L3 in patients with chronic hepatitis, cirrhosis and hepatocellular carcinoma. (18422961)
2008
28
Chemokine system polymorphisms, survival and hepatocellular carcinoma occurrence in patients with hepatitis C virus-related cirrhosis. (18205260)
2008
29
Rab23 is a potential biological target for treating hepatocellular carcinoma. (17373734)
2007
30
Tissue factor pathway inhibitor-2 as a frequently silenced tumor suppressor gene in hepatocellular carcinoma. (17464989)
2007
31
Proliferation and migration mediated by Dkk-1/Wnt/beta-catenin cascade in a model of hepatocellular carcinoma cells. (17964517)
2007
32
Hepatoid adenocarcinoma of the gallbladder: a mimicker of hepatocellular carcinoma. (18065642)
2007
33
Hepatocellular carcinoma and its early detection by AFP testing in Mongolia. (17059345)
2006
34
Hepatocellular carcinoma cells containing hepatitis B virus X protein have enhanced invasive potential conditionally. (16461023)
2006
35
A novel, rapid strategy to form dendritomas from human dendritic cells and hepatocellular carcinoma cell line HCCLM3 cells using mature dendritic cells derived from human peripheral blood CD14+ monocytes within 48 hours of in vitro culture. (15534907)
2004
36
Inducible nitric oxide synthase expression is related to angiogenesis, bcl-2 and cell proliferation in hepatocellular carcinoma. (12659238)
2003
37
Platelet-derived endothelial cell growth factor (PD-ECGF) is up-regulated in human hepatocellular carcinoma (HCC) and the corresponding hepatitis liver. (14571777)
2003
38
Methylation framework of cell cycle gene inhibitors in cirrhosis and associated hepatocellular carcinoma. (12143052)
2002
39
Expression of a tumor-associated antigen RCAS1 in hepatocellular carcinoma. (11403925)
2001
40
A case of hepatocellular carcinoma mimicking cavernous hemangioma on Tc-99m RBC liver SPECT. (11245128)
2001
41
Microsatellite instability in European hepatocellular carcinoma. (9926933)
1999
42
The role of MMP-2 in the invasion and metastasis of hepatocellular carcinoma (HCC)]. (9772533)
1997
43
Microheterogeneity of serum transferrin in the diagnosis of hepatocellular carcinoma. (8713703)
1996
44
Gene expression of mutant erythropoietin in hepatocellular carcinoma. (8396923)
1993
45
Carbohydrate structures of human alpha-fetoprotein of patients with hepatocellular carcinoma: presence of fucosylated and non-fucosylated triantennary glycans. (7679920)
1993
46
Molecular analysis of the p53 alleles in primary hepatocellular carcinomas and cell lines. (1847999)
1991
47
Serum CA 19-9 and alpha-fetoprotein levels in primary hepatocellular carcinoma and liver cirrhosis. (1717126)
1991
48
Characterization of high-molecular-mass forms of basic fibroblast growth factor produced by hepatocellular carcinoma cells: possible involvement of basic fibroblast growth factor in hepatocarcinogenesis. (1721615)
1991
49
Late recurrence of a hepatocellular carcinoma in a patient with incomplete Alagille syndrome. (2170223)
1990
50
Pityriasis rotunda. A cutaneous marker of hepatocellular carcinoma in South African blacks. (3015046)
1986

Genetic Variations for Hepatocellular Carcinoma

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62UniProtKB/Swiss-Prot
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Genetic disease variations for Hepatocellular Carcinoma:

62 (show all 20)
id Symbol AA change Variation ID SNP ID
1AXIN1p.Leu106ArgVAR_015589
2AXIN1p.Pro345LeuVAR_015590
3AXIN1p.Gly425SerVAR_015591rs116350678
4AXIN1p.Gly650SerVAR_015592rs117208012
5CDKN3p.Trp31ArgVAR_013842
6CDKN3p.Phe78LeuVAR_013843
7CDKN3p.Cys79TyrVAR_013844
8CDKN3p.Asn91LysVAR_013845
9CDKN3p.Asp94ValVAR_013846
10CDKN3p.Leu95PheVAR_013847
11CDKN3p.Ile108ValVAR_013848rs144479038
12CDKN3p.Asn187SerVAR_013849
13CDKN3p.Lys195IleVAR_013850
14METp.Thr1173IleVAR_032490
15METp.Lys1244ArgVAR_032492
16METp.Met1250IleVAR_032493
17MTUS1p.Gln75LysVAR_035173rs61733703
18MTUS1p.Ala563SerVAR_035178
19MTUS1p.Asn873HisVAR_035180rs187103704
20MTUS1p.Gln1201ArgVAR_035184

Expression for genes affiliated with Hepatocellular Carcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hepatocellular Carcinoma

Search GEO for disease gene expression data for Hepatocellular Carcinoma.

Pathways for genes affiliated with Hepatocellular Carcinoma

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29KEGG, 12EMD Millipore, 51QIAGEN
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Pathways related to Hepatocellular Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.4MET, EGF, AXIN1, TP53
2
Hide members
11.2TP53, AXIN1, EGF
311.2TP53, AXIN1, EGF

Compounds for genes affiliated with Hepatocellular Carcinoma

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 59Tocris Bioscience
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Compounds related to Hepatocellular Carcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1actinomycin d4411.4TP53, CDKN3, EGF, MET
2gefitinib44 49 1113.3CDKN3, EGF, MET
3geldanamycin44 49 59 1114.2MET, EGF, TP53
4nocodazole44 1112.2TP53, CDKN3, EGF
5ly2940024411.1TP53, CDKN3, EGF, MET
6erbstatin4410.8EGF, CDKN3

GO Terms for genes affiliated with Hepatocellular Carcinoma

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16Gene Ontology
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Biological processes related to Hepatocellular Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of peptidyl-threonine phosphorylationGO:01080010.9AXIN1, EGF
2positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic processGO:200006010.6AXIN1, EGF

Products for genes affiliated with Hepatocellular Carcinoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hepatocellular Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet