HCC
MCID: HPT023
MIFTS: 69

Hepatocellular Carcinoma (HCC) malady

Liver, Cancer categories

Summaries for Hepatocellular Carcinoma

Sources:
8Disease Ontology, 34MedlinePlus, 64Wikipedia, 47OMIM, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MedlinePlus:34 Your liver is the largest organ inside your body. it helps your body digest food, store energy, and remove poisons. primary liver cancer starts in the liver. metastatic liver cancer starts somewhere else and spreads to your liver. risk factors for primary liver cancer include having hepatitis b or c heavy alcohol use having cirrhosis, or scarring of the liver having hemochromatosis, an iron storage disease obesity and diabetes symptoms can include a lump or pain on the right side of your abdomen and yellowing of the skin. however, you may not have symptoms until the cancer is advanced. this makes it harder to treat. doctors use tests that examine the liver and the blood diagnose liver cancer. treatment options include surgery, radiation, chemotherapy, or liver transplantation. nih: national cancer institute

MalaCards: Hepatocellular Carcinoma, also known as liver cancer, is related to hepatitis c and hepatitis c virus. An important gene associated with Hepatocellular Carcinoma is TP53 (tumor protein p53). The drugs mechlorethamine and irinotecan and the compound sulindac sulfide have been mentioned in the context of this disorder. Affiliated tissues include the liver.

Disease Ontology:8 A gastrointestinal system cancer that is located in the liver.

Wikipedia:64 Hepatocellular carcinoma (HCC, also called malignant hepatoma) is the most common type of liver cancer.... more...

Description from OMIM:47 114550

Aliases & Classifications for Hepatocellular Carcinoma

Sources:
8Disease Ontology, 47OMIM, 10DISEASES, 45Novoseek, 43NIH Rare Diseases, 61UMLS, 34MedlinePlus, 22GTR, 49Orphanet, 40NCIt, 35MeSH, 57SNOMED-CT, 26ICD10 via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Liver


Aliases & Descriptions:

hepatocellular carcinoma 8 47 10 45
liver cancer 8 43 34
adult primary hepatocellular carcinoma 8 61
primary malignant neoplasm of liver 8 61
malignant hepato-biliary neoplasm 8 61
hepatocellular cancer 43 22
liver carcinoma 8 61
liver neoplasm 8 10
hepatic cancer 8 45
hepatoma 8 43
hcc 8 43
epithelial hepatic and intrahepatic bile duct neoplasm 8
malignant neoplasm of liver, not specified as primary 8
non-resectable primary hepatic malignant neoplasm 8
liver and intrahepatic biliary tract carcinoma 61
resectable malignant neoplasm of the liver 8
carcinoma of liver, specified as primary 8
primary malignant neoplasm of liver nos 8
malignant neoplasm of liver unspecified 8
resectable malignant neoplasm of liver 8
hepatocellular carcinoma of the mouse 61
primary carcinoma of the liver cells 8
malignant neoplasm of liver, primary 8
hepatocellular carcinoma, adult 43
adult hepatocellular carcinoma 49
adult primary liver carcinoma 8
malignant neoplasm of liver 8
primary carcinoma of liver 8
malignant tumor of liver 8
primary liver cancer 8
neoplasm metastasis 61
ca liver - primary 8
neoplasm of liver 8
hepatic neoplasm 8
liver neoplasms 61
hepatocarcinoma 43
adult hepatoma 8
secondary 8


Related Diseases for Hepatocellular Carcinoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Hepatocellular Carcinoma:



Diseases related to hepatocellular carcinoma

Clinical Features for Hepatocellular Carcinoma

Sources:
47OMIM
See all sources

Clinical features from OMIM:

114550

Drugs & Therapeutics for Hepatocellular Carcinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Genetic Tests for Hepatocellular Carcinoma

Sources:
22GTR
See all sources

Genetic tests related to Hepatocellular Carcinoma:

id Genetic test Affiliating Genes
1 Hepatocellular Carcinoma22

Anatomical Context for Hepatocellular Carcinoma

Sources:
14FMA
See all sources

FMA organs/tissues related to Hepatocellular Carcinoma:

14
The liver

Animal Models for Hepatocellular Carcinoma or affiliated genes

Sources:
28inGenious Targeting Laboratory
See all sources

Publications for Hepatocellular Carcinoma

Sources:
51PubMed
See all sources

Articles related to Hepatocellular Carcinoma:

(show top 50)    (show all 6535)
idTitleAuthorsYear
1
Epirubicin, Cisplatin, 5-FU combination chemotherapy in sorafenib-refractory metastatic hepatocellular carcinoma. (24415877)
2014
2
The down-regulation of Notch1 inhibits the invasion and migration of hepatocellular carcinoma cells by inactivating the cyclooxygenase-2/Snail/E-cadherin pathway in vitro. (23053901)
2013
3
SL1122-37, a novel derivative of sorafenib, has greater effects than sorafenib on the inhibition of human hepatocellular carcinoma (HCC) growth and prevention of angiogenesis. (24241174)
2013
4
Somatostatin receptor subtypes 2 and 5 are associated with better survival in operable hepatitis B-related hepatocellular carcinoma following octreotide long-acting release treatment. (24137418)
2013
5
Therapeutically targeting glypican-3 via a conformation-specific single-domain antibody in hepatocellular carcinoma. (23471984)
2013
6
Human O6 -methylguanine-DNA methyltransferase containing C145A does not prevent hepatocellular carcinoma in C3HeB/FeJ transgenic mice. (22213062)
2013
7
Dyskerin overexpression in human hepatocellular carcinoma is associated with advanced clinical stage and poor patient prognosis. (22912812)
2012
8
Hepatic angiomyolipoma with minimal fat, mimicking hepatocellular carcinoma. (23091816)
2012
9
CHK1 targets spleen tyrosine kinase (L) for proteolysis in hepatocellular carcinoma. (22585575)
2012
10
Association between fibroblast growth factor receptor 4 polymorphisms and risk of hepatocellular carcinoma. (21656577)
2012
11
Loss of membranous carcinoembryonic antigen-related cell adhesion molecule 1 expression is related to decreased relapse-free survival of hepatocellular carcinoma following liver transplantation. (22932077)
2012
12
Lack of association between stretch-activated and volume-activated Cla8> currents in hepatocellular carcinoma cells. (20945353)
2011
13
DNA methylation suppresses expression of the urea cycle enzyme carbamoyl phosphate synthetase 1 (CPS1) in human hepatocellular carcinoma. (21281797)
2011
14
Integrin-linked kinase overexpression and its oncogenic role in promoting tumorigenicity of hepatocellular carcinoma. (21347395)
2011
15
Development of glycoprotein capture-based label-free method for the high-throughput screening of differential glycoproteins in hepatocellular carcinoma. (21474793)
2011
16
Acetylcholinesterase, a key prognostic predictor for hepatocellular carcinoma, suppresses cell growth and induces chemosensitization. (21274871)
2011
17
Glutamine synthetase as an early marker for hepatocellular carcinoma based on proteomic analysis of resected small hepatocellular carcinomas. (20525558)
2010
18
Reduced risk of hepatocellular carcinoma after interferon therapy in aged patients with chronic hepatitis C is limited to sustained virological responders. (19709362)
2010
19
Frequent down-regulation and deletion of KLF6 in primary hepatocellular carcinoma. (20714872)
2010
20
Suppression of tumorigenesis and metastasis of hepatocellular carcinoma by shRNA interference targeting on homeoprotein Six1. (20013809)
2010
21
Inhibition of neuropilin-1 by RNA-interference and its angiostatic potential in the treatment of hepatocellular carcinoma. (20072992)
2010
22
Stromal cell-derived factor-1 but not its receptor, CXCR4, gene variants increase susceptibility and pathological development of hepatocellular carcinoma. (19327121)
2009
23
Anti-glypican 3 antibodies cause ADCC against human hepatocellular carcinoma cells. (19022220)
2009
24
Expression of p53, Bcl-2, VEGF, Ki67 and PCNA and prognostic significance in hepatocellular carcinoma. (19104702)
2008
25
Prognostic analysis of pulmonary metastases from hepatocellular carcinoma. (19669310)
2008
26
Bilateral breast cancer in a male patient with hepatocellular carcinoma. A case report. (18727274)
2008
27
Aberrant expression of the glycolytic enzymes aldolase B and type II hexokinase in hepatocellular carcinoma are predictive markers for advanced stage, early recurrence and poor prognosis. (18357395)
2008
28
Identification and characterization of BH3 domain protein Bim and its isoforms in human hepatocellular carcinomas. (17503221)
2007
29
TP53 mutations and hepatocellular carcinoma: insights into the etiology and pathogenesis of liver cancer. (17401425)
2007
30
The receptor for beta(2)GP I on membrane of hepatocellular carcinoma cell line SMMC-7721 is annexin II. (17659677)
2007
31
Functional polymorphisms in the promoters of MMP-1, MMP-2, MMP-3, MMP-9, MMP-12 and MMP-13 are not associated with hepatocellular carcinoma risk. (17339256)
2007
32
Metastatic eyelid disease associated with hepatocellular carcinoma. (17724490)
2007
33
Effects of melittin on growth and angiogenesis of human hepatocellular carcinoma BEL-7402 cell xenografts in nude mice]. (18076793)
2007
34
The expression levels of the translational factors eEF1A 1/2 correlate with cell growth but not apoptosis in hepatocellular carcinoma cell lines with different differentiation grade. (17825975)
2007
35
Claudin-4 differentiates biliary tract cancers from hepatocellular carcinomas. (16439986)
2006
36
Cytotoxic T cell responses to human telomerase reverse transcriptase in patients with hepatocellular carcinoma. (16729333)
2006
37
Molecular markers of hepatitis C virus-related hepatocellular carcinoma. (16627984)
2006
38
Overexpression of decoy receptor 3 in hepatocellular carcinoma and its association with resistance to Fas ligand-mediated apoptosis. (16273601)
2005
39
Prophylactic alpha interferon treatment increases the therapeutic index of oncolytic vesicular stomatitis virus virotherapy for advanced hepatocellular carcinoma in immune-competent rats. (16227290)
2005
40
Telomerase-dependent virotherapy overcomes resistance of hepatocellular carcinomas against chemotherapy and tumor necrosis factor-related apoptosis-inducing ligand by elimination of Mcl-1. (16103092)
2005
41
A comparative study of P53/MDM2 genes alterations and P53/MDM2 proteins immunoreactivity in liver cirrhosis and hepatocellular carcinoma. (15943041)
2005
42
Transarterial chemoembolization (TACE) for unresectable hepatocellular carcinoma in cirrhotics: functional hepatic reserve and survival. (12630024)
2003
43
Overexpression of X-linked inhibitor of apoptosis in human hepatocellular carcinoma. (14532997)
2003
44
Mutational spectrum of beta-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas. (12101426)
2002
45
Analysis of alterations of WFDC1, a new putative tumour suppressor gene, in hepatocellular carcinoma. (12032731)
2002
46
Heterochronous development of intrahepatic cholangiocellular carcinoma following hepatocellular carcinoma in a hepatitis B virus carrier. (11506304)
2001
47
Sensitive measurement of serum abnormal prothrombin (PIVKA-II) as a marker of hepatocellular carcinoma. (10522021)
1999
48
The non-surgical treatments of hepatocellular carcinomas in a patient with severe hemophilia A. (10370684)
1999
49
Regulation of transforming growth factor-beta1 gene expression and cell proliferation in human hepatocellular carcinoma cells (PLC/PRF/5) by tamoxifen. (10402064)
1999
50
Recombinant interferon-alpha in inoperable hepatocellular carcinoma: a randomized controlled trial. (8383088)
1993

Genetic Variations for Hepatocellular Carcinoma

Expression for genes affiliated with Hepatocellular Carcinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Hepatocellular Carcinoma

Search GEO for disease gene expression data for Hepatocellular Carcinoma.

Pathways for genes affiliated with Hepatocellular Carcinoma

Compounds for genes affiliated with Hepatocellular Carcinoma

Sources:
45Novoseek
See all sources

Compounds related to Hepatocellular Carcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1sulindac sulfide4510.9TP53, EGF

GO Terms for genes affiliated with Hepatocellular Carcinoma

Products for genes affiliated with Hepatocellular Carcinoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hepatocellular Carcinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet