HCC
MCID: HPT023
MIFTS: 54

Hepatocellular Carcinoma (HCC) malady

Cancer diseases, Liver diseases categories
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Summaries for Hepatocellular Carcinoma

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Disease Ontology:8 A liver carcinoma that has material basis in undifferentiated hepatocytes.

MalaCards based summary: Hepatocellular Carcinoma, also known as adult primary hepatocellular carcinoma, is related to liver cancer and hepatitis. An important gene associated with Hepatocellular Carcinoma is PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha), and among its related pathways are p75(NTR)-mediated signaling and Neurotrophic factor-mediated Trk receptor signaling. The drugs interferon alfa-2a and interferon alfa-2b have been mentioned in the context of this disorder. Affiliated tissues include liver, endothelial and t cells.

Description from OMIM:46 114550

Aliases & Classifications for Hepatocellular Carcinoma

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Hepatocellular Carcinoma, Aliases & Descriptions:

Name: Hepatocellular Carcinoma 30 8
Adult Primary Hepatocellular Carcinoma 8 62
Hepatocellular Carcinoma of the Mouse 62
Liver Carcinoma 62
 
Adult Hepatoma 8
Hepatoma 8
Hcc 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Liver diseases


External Ids:

Disease Ontology8 DOID:684
MeSH34 D006528
OMIM46 114550
NCIt39 C7956, C7711

Related Diseases for Hepatocellular Carcinoma

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Graphical network of the top 20 diseases related to Hepatocellular Carcinoma:



Diseases related to hepatocellular carcinoma

Symptoms for Hepatocellular Carcinoma

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Clinical features from OMIM:

114550

Drugs & Therapeutics for Hepatocellular Carcinoma

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Genetic Tests for Hepatocellular Carcinoma

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Anatomical Context for Hepatocellular Carcinoma

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MalaCards organs/tissues related to Hepatocellular Carcinoma:

32
Liver, Endothelial, T cells, Colon, Lung, Bone, Testis, Testes, Thyroid, Breast, Monocytes, Lymph node, Smooth muscle, B cells, Spleen, Prostate, Neutrophil, Kidney, Skin, Myeloid, Placenta, Fetal liver, Pituitary, Bone marrow, Brain, Spinal cord, Skeletal muscle, Pancreas, Adrenal gland, Ovary, Appendix

Animal Models for Hepatocellular Carcinoma or affiliated genes

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Publications for Hepatocellular Carcinoma

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Articles related to Hepatocellular Carcinoma:

(show top 50)    (show all 6742)
idTitleAuthorsYear
1
Low expression of PAI-2 as a novel marker of portal vein tumor thrombosis and poor prognosis in hepatocellular carcinoma. (23188538)
2013
2
Modification of sialylation mediates the invasive properties and chemosensitivity of human hepatocellular carcinoma. (24255131)
2013
3
Complete pathological regression of hepatocellular carcinoma with portal vein thrombosis treated with sorafenib. (23914915)
2013
4
Combination of SLC administration and tregs depletion is an attractive strategy for targeting hepatocellular carcinoma. (24304581)
2013
5
Interobserver agreement of semi-automated and manual measurements of functional MRI metrics of treatment response in hepatocellular carcinoma. (24387824)
2013
6
Combining Locoregional Therapies in the Treatment of Hepatocellular Carcinoma. (24436520)
2013
7
Significant association between XRCC3 C241T polymorphism and increased risk of hepatocellular carcinoma: a meta-analysis. (23873110)
2013
8
Expression of FOXJ1 in hepatocellular carcinoma: correlation with patients' prognosis and tumor cell proliferation. (22488567)
2013
9
Clinical significance of therapy using branched-chain amino acid granules in patients with liver cirrhosis and hepatocellular carcinoma. (23819582)
2013
10
Effect of one-off complete tumor radiofrequency ablation on liver function and postoperative complication in small hepatocellular carcinoma. (24387942)
2013
11
The effect of alkaline phosphatase and intrahepatic metastases in large hepatocellular carcinoma. (23432910)
2013
12
Notch1 activation contributes to tumor cell growth and proliferation in human hepatocellular carcinoma HepG2 and SMMC7721 cells. (22922832)
2012
13
Comparative analyses of regulatory T cell subsets in patients with hepatocellular carcinoma: a crucial role of CD25(-) FOXP3(-) T cells. (22419479)
2012
14
Metabonomic profiles discriminate hepatocellular carcinoma from liver cirrhosis by ultraperformance liquid chromatography-mass spectrometry. (22200553)
2012
15
Total and high molecular weight adiponectin and hepatocellular carcinoma with HCV infection. (22110596)
2011
16
Underexpressed microRNA-199b-5p targets hypoxia-inducible factor-1I+ in hepatocellular carcinoma and predicts prognosis of hepatocellular carcinoma patients. (21557766)
2011
17
Epidermal growth factor-containing fibulin-like extracellular matrix protein 1, EFEMP1, a novel tumor-suppressor gene detected in hepatocellular carcinoma using double combination array analysis. (19898900)
2010
18
Hepatocellular carcinoma and regenerating nodule in a 3-year-old child with Alagille syndrome. (20714715)
2010
19
Expression of I+-taxilin in hepatocellular carcinoma correlates with growth activity and malignant potential of the tumor. (21042709)
2010
20
Expression characteristics of nuclear factor kappa B in hepatocellular carcinoma tissues]. (19958645)
2009
21
Role of serum prothrombin induced by vitamin K absence or antagonist-II in the early detection of hepatocellular carcinoma in patients with chronic hepatitis B virus infection. (19391065)
2009
22
Expression of KiSS-1 gene and its role in invasion and metastasis of human hepatocellular carcinoma. (19645016)
2009
23
Expression of STK15 mRNA in hepatocellular carcinoma and its prognostic significance. (19232520)
2009
24
Association analysis between the Cdc6 G1321A polymorphism and the risk for non-Hodgkin lymphoma and hepatocellular carcinoma. (19101572)
2009
25
Glycomic analysis of alpha-fetoprotein L3 in hepatoma cell lines and hepatocellular carcinoma patients. (18479159)
2008
26
Epigenetic instability is rare in fibrolamellar carcinomas but common in viral-associated hepatocellular carcinomas. (18264082)
2008
27
Inhibitory effect of RNAi targeting human telomerase reverse transcriptase against human hepatocellular carcinoma cells]. (18753050)
2008
28
No association exists between E-cadherin gene polymorphism and tumor recurrence in patients with hepatocellular carcinoma after transplantation. (17548247)
2007
29
UDP-glucuronosyltransferase UGT1A7 genetic polymorphisms in hepatocellular carcinoma: a differential impact according to seropositivity of HBV or HCV markers? (18021430)
2007
30
Novel identification of zyxin upregulations in the motile phenotype of hepatocellular carcinoma. (16680155)
2006
31
Role of immunosuppression and tumor differentiation in predicting recurrence after liver transplantation for hepatocellular carcinoma: a multicenter study of 412 patients. (17143948)
2006
32
Expression of epithelial cellular adhesion molecule (Ep-CAM) in chronic (necro-)inflammatory liver diseases and hepatocellular carcinoma. (16364680)
2006
33
UDP-glucuronosyltransferase 1A7 genetic polymorphisms are associated with hepatocellular carcinoma risk and onset age. (16086712)
2005
34
Acyclic retinoid in the chemoprevention of hepatocellular carcinoma (review). (15010815)
2004
35
High levels of p53 protein expression do not correlate with p53 mutations in hepatocellular carcinoma. (15500550)
2004
36
CD44 and VEGF expression in extrahepatic metastasis of human hepatocellular carcinoma. (15239258)
2004
37
Metastatic hepatocellular carcinoma of gingiva mimicking pyogenic granuloma. (12894096)
2003
38
Factors related to acute upper gastrointestinal bleeding after transcatheter arterial chemoembolization in patients with hepatocellular carcinoma]. (12478898)
2002
39
Enzymatic activity of cathepsin B, cathepsin B and L, plasmin, trypsin and collagenase in hepatocellular carcinoma]. (12412410)
2002
40
Subacute cutaneous lupus erythematosus associated with hepatocellular carcinoma. (11309033)
2001
41
Effects of vascular endothelial growth factor on adhesion molecular expression of hepatocellular carcinoma HepG]. (11509135)
2001
42
Lack of frameshift mutations at coding mononucleotide repeats in hepatocellular carcinoma in Japanese patients. (10699890)
2000
43
Circulating intercellular adhesion molecule-1 in chronic liver disease and hepatocellular carcinoma. (10462824)
1999
44
Retrovirus-mediated gene therapy for hepatocellular carcinoma: selective and enhanced suicide gene expression regulated by human alpha-fetoprotein enhancer directly linked to its promoter. (9824049)
1998
45
Up-regulation of peripheral benzodiazepine receptor system in hepatocellular carcinoma. (9771915)
1998
46
Detection of a unique gamma-glutamyl transpeptidase messenger RNA species closely related to the development of hepatocellular carcinoma in humans: a new candidate for early diagnosis of hepatocellular carcinoma. (8621139)
1996
47
Hepatocellular carcinoma associated with alcoholic liver disease: a clinicopathological study and genetic polymorphism of aldehyde dehydrogenase 2. (8986242)
1996
48
Comparison of clinico-pathological features in hepatitis B virus-associated hepatocellular carcinoma with or without hepatitis D virus superinfection. (8912142)
1996
49
p53 mutations and aflatoxin B1 exposure in hepatocellular carcinoma patients from Thailand. (8380058)
1993
50
Late recurrence of a hepatocellular carcinoma in a patient with incomplete Alagille syndrome. (2170223)
1990

Variations for Hepatocellular Carcinoma

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Clinvar genetic disease variations for Hepatocellular Carcinoma:

6
id Gene Name Type Significance SNP ID Assembly Location
1PIK3CANM_006218.2(PIK3CA): c.3140A> G (p.His1047Arg)single nucleotide variantPathogenicrs121913279GRCh37Chr 3, 178952085: 178952085

Expression for genes affiliated with Hepatocellular Carcinoma

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Expression patterns in normal tissues for genes affiliated with Hepatocellular Carcinoma

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Pathways for genes affiliated with Hepatocellular Carcinoma

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Pathways related to Hepatocellular Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.3NDNL2, PIK3CA
2
Show member pathways
10.3EHD4, PIK3CA

Compounds for genes affiliated with Hepatocellular Carcinoma

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GO Terms for genes affiliated with Hepatocellular Carcinoma

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Cellular components related to Hepatocellular Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:0056349.5ZC4H2, EHD4, VPS37A, C9orf78, YY1AP1, CHP2

Products for genes affiliated with Hepatocellular Carcinoma

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Sources for Hepatocellular Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet