Hepatocellular Carcinoma malady
Categories: Genetic diseases, Rare diseases, Liver diseases, Cancer diseases, Gastrointestinal diseases
50OMIM, 33LifeMap Discovery®, 11Disease Ontology, 46NIH Rare Diseases, 13DISEASES, 52Orphanet, 68UniProtKB/Swiss-Prot, 25GTR, 12diseasecard, 48Novoseek, 36MedlinePlus, 37MeSH, 66UMLS, 28ICD10, 30ICD9CM, 43NCIt, 29ICD10 via Orphanet, 38MESH via Orphanet, 67UMLS via Orphanet, 35MedGen, 60SNOMED-CT, 62The Human Phenotype Ontology
See all MalaCards sources
Aliases & Descriptions for Hepatocellular Carcinoma:
Orphanet epidemiological data:52
Inheritance: Not applicable; Prevalence: <1/1000000 (Europe),1-9/1000000 (Europe); Age of onset: Childhood,Infancy,Neonatal; Age of death: early childhood,infantile
adult hepatocellular carcinoma:
Inheritance: Not applicable
Inheritance: Not applicable; Prevalence: 1-9/100000 (United States),1-5/10000 (Europe); Age of onset: All ages; Age of death: adult
Global: Genetic diseases, Rare diseases, Cancer diseases
Anatomical: Liver diseases, Gastrointestinal diseases
ICD10: 29 28
Rare hepatic diseases
MedlinePlus:36 Your liver is the largest organ inside your body. it helps your body digest food, store energy, and remove poisons. primary liver cancer starts in the liver. metastatic liver cancer starts somewhere else and spreads to your liver. risk factors for primary liver cancer include having hepatitis b or c heavy alcohol use having cirrhosis, or scarring of the liver having hemochromatosis, an iron storage disease obesity and diabetes symptoms can include a lump or pain on the right side of your abdomen and yellowing of the skin. however, you may not have symptoms until the cancer is advanced. this makes it harder to treat. doctors use tests that examine the liver and the blood to diagnose liver cancer. treatment options include surgery, radiation, chemotherapy, or liver transplantation. nih: national cancer institute
MalaCards based summary: Hepatocellular Carcinoma, also known as liver cancer, is related to glomerulonephritis and plasmacytoma, and has symptoms including hepatomegaly, hepatosplenomegaly and abdominal pain. An important gene associated with Hepatocellular Carcinoma is AXIN1 (Axin 1), and among its related pathways are Pathways in cancer and Wnt Signaling Pathways: beta-Catenin-independent Wnt/PCP Signaling Pathways. The drugs interferon alfa-2a and interferon alfa-2b have been mentioned in the context of this disorder. Affiliated tissues include the liver, liver and breast, and related mouse phenotypes are cellular and liver/biliary system.
Disease Ontology:11 A gastrointestinal system cancer that is located in the liver.
UniProtKB/Swiss-Prot:68 Hepatocellular carcinoma: A primary malignant neoplasm of epithelial liver cells. The major risk factors for HCC are chronic hepatitis B virus (HBV) infection, chronic hepatitis C virus (HCV) infection, prolonged dietary aflatoxin exposure, alcoholic cirrhosis, and cirrhosis due to other causes.
OMIM:50 Hepatocellular carcinoma is the major histologic type of malignant primary liver neoplasm. It is the fifth most common... (114550) more...
Wikipedia:69 Hepatocellular carcinoma (HCC), also called malignant hepatoma, is the most common type of liver cancer. more...
UMLS symptoms related to Hepatocellular Carcinoma:hepatomegaly, hepatosplenomegaly, abdominal pain, malaise, constipation, diarrhea, dyspepsia, heartburn, nausea and vomiting, gastrointestinal gas
FDA approved drugs:
Drugs for Hepatocellular Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):(show top 50) (show all 503)
Interventional clinical trials:(show top 50) (show all 3173)
Search NIH Clinical Center for Hepatocellular Carcinoma
Inferred drug relations via UMLS66/NDF-RT44:
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Hepatocellular Carcinoma cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Hepatocellular Carcinoma:
Embryonic/Adult Cultured Cells Related to Hepatocellular Carcinoma:
MalaCards organs/tissues related to Hepatocellular Carcinoma:34
Liver, Breast, Lung, T cells, Prostate, Endothelial, Colon
FMA organs/tissues related to Hepatocellular Carcinoma:17
MGI Mouse Phenotypes related to Hepatocellular Carcinoma:39 (show all 17)
Articles related to Hepatocellular Carcinoma:(show top 50) (show all 8542)
UniProtKB/Swiss-Prot genetic disease variations for Hepatocellular Carcinoma:68 (show all 21)
Clinvar genetic disease variations for Hepatocellular Carcinoma:5 (show all 13)
Cosmic variations for Hepatocellular Carcinoma:8 (show top 50) (show all 569)
Copy number variations for Hepatocellular Carcinoma from CNVD:6 (show top 50) (show all 259)
Genes differentially expressed in tissues of Hepatocellular Carcinoma patients vs. healthy controls: 33
Search GEO for disease gene expression data for Hepatocellular Carcinoma.
Pathways related to Hepatocellular Carcinoma according to GeneCards Suite gene sharing:(show all 22)
Cellular components related to Hepatocellular Carcinoma according to GeneCards Suite gene sharing:
Biological processes related to Hepatocellular Carcinoma according to GeneCards Suite gene sharing:(show all 9)
Molecular functions related to Hepatocellular Carcinoma according to GeneCards Suite gene sharing:
29ICD10 via Orphanet
38MESH via Orphanet
51OMIM via Orphanet
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
67UMLS via Orphanet