HCC
MCID: HPT023
MIFTS: 89

Hepatocellular Carcinoma (HCC) malady

Liver diseases, Cancer diseases categories

Summaries for Hepatocellular Carcinoma

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Sources:
8Disease Ontology, 33MedlinePlus, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Your liver is the largest organ inside your body. it helps your body digest food, store energy, and remove poisons. primary liver cancer starts in the liver. metastatic liver cancer starts somewhere else and spreads to your liver. risk factors for primary liver cancer include having hepatitis b or c heavy alcohol use having cirrhosis, or scarring of the liver having hemochromatosis, an iron storage disease obesity and diabetes symptoms can include a lump or pain on the right side of your abdomen and yellowing of the skin. however, you may not have symptoms until the cancer is advanced. this makes it harder to treat. doctors use tests that examine the liver and the blood diagnose liver cancer. treatment options include surgery, radiation, chemotherapy, or liver transplantation. nih: national cancer institute

MalaCards: Hepatocellular Carcinoma, also known as liver cancer, is related to hepatoblastoma and melanoma. An important gene associated with Hepatocellular Carcinoma is TP53 (tumor protein p53), and among its related pathways are Pathways in cancer and Endometrial cancer. The drugs mechlorethamine and irinotecan and the compounds actinomycin d and gefitinib have been mentioned in the context of this disorder. Affiliated tissues include the liver, liver and endothelial.

Disease Ontology:8 A gastrointestinal system cancer that is located in the liver.

Wikipedia:63 Hepatocellular carcinoma (HCC, also called malignant hepatoma) is the most common type of liver cancer.... more...

Description from OMIM:46 114550

Aliases & Classifications for Hepatocellular Carcinoma

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Sources:
8Disease Ontology, 46OMIM, 10DISEASES, 44Novoseek, 42NIH Rare Diseases, 60UMLS, 33MedlinePlus, 22GTR, 48Orphanet, 39NCIt, 34MeSH, 56SNOMED-CT, 26ICD10 via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Liver diseases


Aliases & Descriptions:

hepatocellular carcinoma 8 46 10 44
liver cancer 8 42 33
adult primary hepatocellular carcinoma 8 60
primary malignant neoplasm of liver 8 60
malignant hepato-biliary neoplasm 8 60
hepatocellular cancer 42 22
liver carcinoma 8 60
liver neoplasm 8 10
hepatic cancer 8 44
hepatoma 8 42
hcc 8 42
epithelial hepatic and intrahepatic bile duct neoplasm 8
malignant neoplasm of liver, not specified as primary 8
non-resectable primary hepatic malignant neoplasm 8
liver and intrahepatic biliary tract carcinoma 60
resectable malignant neoplasm of the liver 8
carcinoma of liver, specified as primary 8
primary malignant neoplasm of liver nos 8
malignant neoplasm of liver unspecified 8
resectable malignant neoplasm of liver 8
hepatocellular carcinoma of the mouse 60
primary carcinoma of the liver cells 8
malignant neoplasm of liver, primary 8
hepatocellular carcinoma, adult 42
adult hepatocellular carcinoma 48
adult primary liver carcinoma 8
malignant neoplasm of liver 8
primary carcinoma of liver 8
malignant tumor of liver 8
primary liver cancer 8
neoplasm metastasis 60
ca liver - primary 8
neoplasm of liver 8
hepatic neoplasm 8
liver neoplasms 60
hepatocarcinoma 42
adult hepatoma 8
secondary 8


Related Diseases for Hepatocellular Carcinoma

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Hepatocellular Carcinoma:



Diseases related to hepatocellular carcinoma

Clinical Features for Hepatocellular Carcinoma

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46OMIM
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Clinical features from OMIM:

114550

Drugs & Therapeutics for Hepatocellular Carcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Hepatocellular Carcinoma

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22GTR
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Genetic tests related to Hepatocellular Carcinoma:

id Genetic test Affiliating Genes
1 Hepatocellular Carcinoma22

Anatomical Context for Hepatocellular Carcinoma

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Hepatocellular Carcinoma:

32
Liver, Endothelial, T cells, Testes, Skin, Colon, Lung, Bone, Testis, Thyroid, Breast, Monocytes, Lymph node, B cells, Smooth muscle, Spleen, Prostate, Kidney, Bone marrow, Fetal liver, Myeloid, Placenta, Pituitary, Pancreas, Ovary, Adrenal gland, Skeletal muscle, Brain, Appendix

FMA organs/tissues related to Hepatocellular Carcinoma:

14
The liver

Animal Models for Hepatocellular Carcinoma or affiliated genes

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Publications for Hepatocellular Carcinoma

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Sources:
50PubMed
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Articles related to Hepatocellular Carcinoma:

(show top 50)    (show all 6532)
idTitleAuthorsYear
1
Hepatitis B virus X protein promotes P3 transcript expression of the insulin-like growth factor 2 (IGF2) gene via inducing hypomethylation of P3 promoter in hepatocellular carcinoma. (24423280)
2014
2
Prognostic factors in patients with hepatitis B virus-related hepatocellular carcinoma undergoing nucleoside analog antiviral therapy. (24179497)
2013
3
Prognostic value of I+-fetoprotein and des-I^-carboxy prothrombin responses in patients with hepatocellular carcinoma treated with transarterial chemoembolization. (23282286)
2013
4
The association between cyclooxygenase-2 1195A G/A polymorphism and hepatocellular carcinoma: evidence from a meta-analysis. (23494177)
2013
5
Branched-chain amino acids ameliorate fibrosis and suppress tumor growth in a rat model of hepatocellular carcinoma with liver cirrhosis. (24223741)
2013
6
Aberrant methylation of SPARC in human hepatocellular carcinoma and its clinical implication. (22563191)
2012
7
A genetic variant in the promoter region of miR-106b-25 cluster and risk of HBV infection and hepatocellular carcinoma. (22393390)
2012
8
The role of RhoC in the proliferation and apoptosis of hepatocellular carcinoma cells. (21674277)
2012
9
Serum DKK1 as a protein biomarker for the diagnosis of hepatocellular carcinoma: a large-scale, multicentre study. (22738799)
2012
10
IL-6 -174G/C polymorphism and IL-6 serum levels in patients with liver cirrhosis and hepatocellular carcinoma. (21329460)
2011
11
Inhibition of glypican-3 expression via RNA interference influences the growth and invasive ability of the MHCC97-H human hepatocellular carcinoma cell line. (21617840)
2011
12
Significance of DNA polymerase delta catalytic subunit p125 induced by mutant p53 in the invasive potential of human hepatocellular carcinoma. (21372597)
2010
13
Meta-analysis of the relationship between polymorphisms of 399 point of X-ray repair cross complementing gene group 1 and hepatocellular carcinoma]. (21351626)
2010
14
Intrahepatic cholangiocarcinoma and hepatocellular carcinoma: differential diagnosis with contrast-enhanced ultrasound. (19760416)
2010
15
Expression of Src and FAK in hepatocellular carcinoma and the effect of Src inhibitors on hepatocellular carcinoma in vitro. (18979199)
2009
16
CD133-positive hepatocellular carcinoma in an area endemic for hepatitis B virus infection. (19744348)
2009
17
Programmed cell death 4 (PDCD4) suppresses metastastic potential of human hepatocellular carcinoma cells. (19480673)
2009
18
Myeloid derived suppressor cells inhibit natural killer cells in patients with hepatocellular carcinoma via the NKp30 receptor. (19551844)
2009
19
Influence of DNA methyltransferase 3b on the expression of cyclin D1 gene and methylation of its promoters in human hepatocellular carcinoma cells]. (19567080)
2009
20
Evolving therapies in the treatment of hepatocellular carcinoma. (19707376)
2008
21
TIP30 induces apoptosis under oxidative stress through stabilization of p53 messenger RNA in human hepatocellular carcinoma. (18519672)
2008
22
Fluorescence of age in serum in detecting liver cirrhosis and hepatocellular carcinoma among patients with anti-HCV antibodies]. (18807486)
2008
23
Liver insulin-like growth factor 2 methylation in hepatitis C virus cirrhosis and further occurrence of hepatocellular carcinoma. (18803353)
2008
24
The progressive elevation of alpha fetoprotein for the diagnosis of hepatocellular carcinoma in patients with liver cirrhosis. (17288606)
2007
25
Low-molecular-weight protein (LMP)2/LMP7 abnormality underlies the downregulation of human leukocyte antigen class I antigen in a hepatocellular carcinoma cell line. (17608862)
2007
26
Phase II study of gemcitabine and oxaliplatin in combination with bevacizumab in patients with advanced hepatocellular carcinoma. (16622265)
2006
27
A study on the association of MTHFR C677T polymorphism with genetic susceptibility to hepatocellular carcinoma]. (16556414)
2006
28
Parthenolide cooperates with NS398 to inhibit growth of human hepatocellular carcinoma cells through effects on apoptosis and G0-G1 cell cycle arrest. (16778086)
2006
29
A dose-dependent decrease in the fraction of cases harboring M6P/IGF2R mutations in hepatocellular carcinomas from the atomic bomb survivors. (17149973)
2006
30
Clinical role of tissue and serum levels of SCCA antigen in hepatocellular carcinoma. (15825162)
2005
31
Detection of alpha-fetoproteins mRNA and melanoma antigen-1 mRNA in peripheral blood of patients with hepatocellular carcinoma and its clinical significance]. (15498320)
2004
32
Ultrasound guided fine needle biopsy of early hepatocellular carcinoma complicating liver cirrhosis: a multicentre study. (15306600)
2004
33
Alterations of RB1, p53 and Wnt pathways in hepatocellular carcinomas associated with hepatitis C, hepatitis B and alcoholic liver cirrhosis. (12845670)
2003
34
Metastatic hepatocellular carcinoma in a patient with niemann-pick disease, type C. (14581809)
2003
35
A comparison of patients with hepatocellular carcinoma between a short-term (less than 6 months) survival group and a long-term (over 24 months) survival group after treatment with transcatheter arterial chemoembolization]. (12499805)
2002
36
Down-regulated expression of atypical PKC-binding domain deleted asip isoforms in human hepatocellular carcinomas. (11642408)
2001
37
Cloning and characterization of a novel gene, DRH1, down-regulated in advanced human hepatocellular carcinoma. (11234883)
2001
38
Prospective validation of the CLIP score: a new prognostic system for patients with cirrhosis and hepatocellular carcinoma. The Cancer of the Liver Italian Program (CLIP) Investigators. (10733537)
2000
39
Clinical significance of urokinase-type plasminogen activator activity in hepatocellular carcinoma. (10824888)
2000
40
Modulating IGFBP-3 expression by trichostatin A: potential therapeutic role in the treatment of hepatocellular carcinoma. (10601571)
2000
41
Is choledocholithiasis a late complication of nonresectional therapies for hepatocellular carcinoma? (10626167)
1999
42
The mutation of deletion for glutathione S-transferase M1 gene in the tissue of hepatocellular carcinoma]. (10359869)
1999
43
Detection of telomerase in hepatocellular carcinomas using a PCR ELISA assay: comparison with hTR expression. (10674027)
1999
44
Hepatocellular carcinoma expressing both hepatocellular and biliary markers also expresses cytokeratin 14, a marker of bipotential progenitor cells. (10580599)
1999
45
Beta-catenin mutations in hepatocellular carcinoma correlate with a low rate of loss of heterozygosity. (10435629)
1999
46
Reduced p21(WAF1/CIP1) expression and p53 mutation in hepatocellular carcinomas. (9049201)
1997
47
Urinary transforming growth factor-beta 1 in relation to serum alpha-fetoprotein in hepatocellular carcinoma. (9085463)
1997
48
Expression of c-erbB-2 protein and EGF receptor in hepatitis B, cirrhosis and hepatocellular carcinoma]. (7788735)
1995
49
Incidence of hepatitis D virus infection in Japanese patients with hepatocellular carcinoma--immunohistochemical investigation of the delta antigen. (1339069)
1992
50
Quantitation of estrogen and androgen receptors in hepatocellular carcinoma and adjacent normal human liver. (1654243)
1991

Genetic Variations for Hepatocellular Carcinoma

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62UniProtKB/Swiss-Prot
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Genetic disease variations for Hepatocellular Carcinoma:

62 (show all 20)
id Symbol AA change Variation ID SNP ID
1AXIN1p.Leu106ArgVAR_015589
2AXIN1p.Pro345LeuVAR_015590
3AXIN1p.Gly425SerVAR_015591rs116350678
4AXIN1p.Gly650SerVAR_015592rs117208012
5CDKN3p.Trp31ArgVAR_013842
6CDKN3p.Phe78LeuVAR_013843
7CDKN3p.Cys79TyrVAR_013844
8CDKN3p.Asn91LysVAR_013845
9CDKN3p.Asp94ValVAR_013846
10CDKN3p.Leu95PheVAR_013847
11CDKN3p.Ile108ValVAR_013848rs144479038
12CDKN3p.Asn187SerVAR_013849
13CDKN3p.Lys195IleVAR_013850
14METp.Thr1173IleVAR_032490
15METp.Lys1244ArgVAR_032492
16METp.Met1250IleVAR_032493
17MTUS1p.Gln75LysVAR_035173rs61733703
18MTUS1p.Ala563SerVAR_035178
19MTUS1p.Asn873HisVAR_035180rs187103704
20MTUS1p.Gln1201ArgVAR_035184

Expression for genes affiliated with Hepatocellular Carcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hepatocellular Carcinoma

Search GEO for disease gene expression data for Hepatocellular Carcinoma.

Pathways for genes affiliated with Hepatocellular Carcinoma

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29KEGG, 12EMD Millipore, 51QIAGEN
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Pathways related to Hepatocellular Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.4MET, EGF, AXIN1, TP53
2
Hide members
11.2TP53, AXIN1, EGF
311.2TP53, AXIN1, EGF

Compounds for genes affiliated with Hepatocellular Carcinoma

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 59Tocris Bioscience
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Compounds related to Hepatocellular Carcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1actinomycin d4411.4TP53, CDKN3, EGF, MET
2gefitinib44 49 1113.3CDKN3, EGF, MET
3geldanamycin44 49 59 1114.2MET, EGF, TP53
4nocodazole44 1112.2TP53, CDKN3, EGF
5ly2940024411.1TP53, CDKN3, EGF, MET
6erbstatin4410.8EGF, CDKN3

GO Terms for genes affiliated with Hepatocellular Carcinoma

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16Gene Ontology
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Biological processes related to Hepatocellular Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of peptidyl-threonine phosphorylationGO:01080010.9AXIN1, EGF
2positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic processGO:200006010.6AXIN1, EGF

Products for genes affiliated with Hepatocellular Carcinoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hepatocellular Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet