Hepatocellular Carcinoma malady
Categories: Genetic diseases, Rare diseases, Liver diseases, Cancer diseases, Gastrointestinal diseases, Neuronal diseases
11Disease Ontology, 12diseasecard, 13DISEASES, 26GTR, 29ICD10, 30ICD10 via Orphanet, 31ICD9CM, 34LifeMap Discovery®, 36MedGen, 37MedlinePlus, 38MeSH, 39MESH via Orphanet, 44NCIt, 47NIH Rare Diseases, 49Novoseek, 51OMIM, 53Orphanet, 61SNOMED-CT, 63The Human Phenotype Ontology, 67UMLS, 68UMLS via Orphanet, 69UniProtKB/Swiss-Prot
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Aliases & Descriptions for Hepatocellular Carcinoma:
Orphanet epidemiological data:53
Inheritance: Not applicable; Prevalence: <1/1000000 (Europe),1-9/1000000 (Europe); Age of onset: Childhood,Infancy,Neonatal; Age of death: early childhood,infantile
Inheritance: Not applicable; Prevalence: 1-9/100000 (United States),1-5/10000 (Europe); Age of onset: All ages; Age of death: adult
adult hepatocellular carcinoma:
Inheritance: Not applicable
Global: Genetic diseases, Rare diseases, Cancer diseases
Anatomical: Liver diseases, Gastrointestinal diseases, Neuronal diseases
ICD10: 30 29
Rare hepatic diseases
MedlinePlus:37 Your liver is the largest organ inside your body. it helps your body digest food, store energy, and remove poisons. primary liver cancer starts in the liver. metastatic liver cancer starts somewhere else and spreads to your liver. risk factors for primary liver cancer include having hepatitis b or c heavy alcohol use having cirrhosis, or scarring of the liver having hemochromatosis, an iron storage disease obesity and diabetes symptoms can include a lump or pain on the right side of your abdomen and yellowing of the skin. however, you may not have symptoms until the cancer is advanced. this makes it harder to treat. doctors use tests that examine the liver and the blood to diagnose liver cancer. treatment options include surgery, radiation, chemotherapy, or liver transplantation. nih: national cancer institute
MalaCards based summary: Hepatocellular Carcinoma, also known as liver cancer, is related to glomerulonephritis and plasmacytoma, and has symptoms including hepatocellular carcinoma, micronodular cirrhosis and subacute progressive viral hepatitis. An important gene associated with Hepatocellular Carcinoma is AXIN1 (Axin 1), and among its related pathways are Pathways in cancer and Apoptosis Pathway. The drugs interferon alfa-2b and recombinant interferon beta-1a have been mentioned in the context of this disorder. Affiliated tissues include the liver, liver and lung, and related mouse phenotypes are cellular and mortality/aging.
Disease Ontology:11 A liver carcinoma that has material basis in undifferentiated hepatocytes.
OMIM:51 Hepatocellular carcinoma is the major histologic type of malignant primary liver neoplasm. It is the fifth most common... (114550) more...
UniProtKB/Swiss-Prot:69 Hepatocellular carcinoma: A primary malignant neoplasm of epithelial liver cells. The major risk factors for HCC are chronic hepatitis B virus (HBV) infection, chronic hepatitis C virus (HCV) infection, prolonged dietary aflatoxin exposure, alcoholic cirrhosis, and cirrhosis due to other causes.
Wikipedia:70 Hepatocellular carcinoma (HCC), also called malignant hepatoma, is the most common type of liver cancer. more...
UMLS symptoms related to Hepatocellular Carcinoma:hepatomegaly, hepatosplenomegaly, abdominal pain, malaise, constipation, diarrhea, dyspepsia, heartburn, nausea and vomiting, gastrointestinal gas, ataxia, hemiplegia, muscle spasticity, seizures, tremor, pyramidal sign, extrapyramidal sign
FDA approved drugs:
Drugs for Hepatocellular Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):(show top 50) (show all 923)
Interventional clinical trials:(show top 50) (show all 3289)
Search NIH Clinical Center for Hepatocellular Carcinoma
Inferred drug relations via UMLS67/NDF-RT45:
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Hepatocellular Carcinoma cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Hepatocellular Carcinoma:
Embryonic/Adult Cultured Cells Related to Hepatocellular Carcinoma:
MalaCards organs/tissues related to Hepatocellular Carcinoma:35
Liver, Lung, T cells, Prostate, Endothelial, Colon, Kidney
FMA organs/tissues related to Hepatocellular Carcinoma:17
MGI Mouse Phenotypes related to Hepatocellular Carcinoma:40 (show all 16)
Articles related to Hepatocellular Carcinoma:(show top 50) (show all 8790)
UniProtKB/Swiss-Prot genetic disease variations for Hepatocellular Carcinoma:69 (show all 21)
Clinvar genetic disease variations for Hepatocellular Carcinoma:5 (show all 20)
Cosmic variations for Hepatocellular Carcinoma:8 (show top 50) (show all 569)
Copy number variations for Hepatocellular Carcinoma from CNVD:6 (show top 50) (show all 259)
Genes differentially expressed in tissues of Hepatocellular Carcinoma patients vs. healthy controls: 34
Search GEO for disease gene expression data for Hepatocellular Carcinoma.
Pathways related to Hepatocellular Carcinoma according to GeneCards Suite gene sharing:(show all 20)
Cellular components related to Hepatocellular Carcinoma according to GeneCards Suite gene sharing:
Biological processes related to Hepatocellular Carcinoma according to GeneCards Suite gene sharing:(show all 10)
Molecular functions related to Hepatocellular Carcinoma according to GeneCards Suite gene sharing:
30ICD10 via Orphanet
39MESH via Orphanet
52OMIM via Orphanet
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
68UMLS via Orphanet