HCC
MCID: HPT023
MIFTS: 89

Hepatocellular Carcinoma (HCC) malady

Liver diseases, Cancer diseases categories

Summaries for Hepatocellular Carcinoma

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Sources:
8Disease Ontology, 33MedlinePlus, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Your liver is the largest organ inside your body. it helps your body digest food, store energy, and remove poisons. primary liver cancer starts in the liver. metastatic liver cancer starts somewhere else and spreads to your liver. risk factors for primary liver cancer include having hepatitis b or c heavy alcohol use having cirrhosis, or scarring of the liver having hemochromatosis, an iron storage disease obesity and diabetes symptoms can include a lump or pain on the right side of your abdomen and yellowing of the skin. however, you may not have symptoms until the cancer is advanced. this makes it harder to treat. doctors use tests that examine the liver and the blood diagnose liver cancer. treatment options include surgery, radiation, chemotherapy, or liver transplantation. nih: national cancer institute

MalaCards: Hepatocellular Carcinoma, also known as liver cancer, is related to hepatoblastoma and melanoma. An important gene associated with Hepatocellular Carcinoma is TP53 (tumor protein p53), and among its related pathways are Pathways in cancer and Endometrial cancer. The drugs mechlorethamine and irinotecan and the compounds actinomycin d and gefitinib have been mentioned in the context of this disorder. Affiliated tissues include the liver, liver and endothelial.

Disease Ontology:8 A gastrointestinal system cancer that is located in the liver.

Wikipedia:63 Hepatocellular carcinoma (HCC, also called malignant hepatoma) is the most common type of liver cancer.... more...

Description from OMIM:46 114550

Aliases & Classifications for Hepatocellular Carcinoma

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Sources:
8Disease Ontology, 46OMIM, 10DISEASES, 44Novoseek, 42NIH Rare Diseases, 60UMLS, 33MedlinePlus, 22GTR, 48Orphanet, 39NCIt, 34MeSH, 56SNOMED-CT, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Liver diseases


Aliases & Descriptions:

hepatocellular carcinoma 8 46 10 44
liver cancer 8 42 33
adult primary hepatocellular carcinoma 8 60
primary malignant neoplasm of liver 8 60
malignant hepato-biliary neoplasm 8 60
hepatocellular cancer 42 22
liver carcinoma 8 60
liver neoplasm 8 10
hepatic cancer 8 44
hepatoma 8 42
hcc 8 42
epithelial hepatic and intrahepatic bile duct neoplasm 8
malignant neoplasm of liver, not specified as primary 8
non-resectable primary hepatic malignant neoplasm 8
liver and intrahepatic biliary tract carcinoma 60
resectable malignant neoplasm of the liver 8
carcinoma of liver, specified as primary 8
primary malignant neoplasm of liver nos 8
malignant neoplasm of liver unspecified 8
resectable malignant neoplasm of liver 8
hepatocellular carcinoma of the mouse 60
primary carcinoma of the liver cells 8
malignant neoplasm of liver, primary 8
hepatocellular carcinoma, adult 42
adult hepatocellular carcinoma 48
adult primary liver carcinoma 8
malignant neoplasm of liver 8
primary carcinoma of liver 8
malignant tumor of liver 8
primary liver cancer 8
neoplasm metastasis 60
ca liver - primary 8
neoplasm of liver 8
hepatic neoplasm 8
liver neoplasms 60
hepatocarcinoma 42
adult hepatoma 8
secondary 8


Related Diseases for Hepatocellular Carcinoma

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Hepatocellular Carcinoma:



Diseases related to hepatocellular carcinoma

Clinical Features for Hepatocellular Carcinoma

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46OMIM
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Clinical features from OMIM:

114550

Drugs & Therapeutics for Hepatocellular Carcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Hepatocellular Carcinoma

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22GTR
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Genetic tests related to Hepatocellular Carcinoma:

id Genetic test Affiliating Genes
1 Hepatocellular Carcinoma22

Anatomical Context for Hepatocellular Carcinoma

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Hepatocellular Carcinoma:

32
Liver, Endothelial, T cells, Testes, Skin, Colon, Lung, Bone, Testis, Thyroid, Breast, Monocytes, Lymph node, B cells, Smooth muscle, Spleen, Prostate, Kidney, Bone marrow, Fetal liver, Myeloid, Placenta, Pituitary, Pancreas, Ovary, Adrenal gland, Skeletal muscle, Brain, Appendix

FMA organs/tissues related to Hepatocellular Carcinoma:

14
The liver

Animal Models for Hepatocellular Carcinoma or affiliated genes

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Publications for Hepatocellular Carcinoma

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Sources:
50PubMed
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Articles related to Hepatocellular Carcinoma:

(show top 50)    (show all 6532)
idTitleAuthorsYear
1
Liver stiffness-based optimization of hepatocellular carcinoma risk score in patients with chronic hepatitis B. (24128413)
2014
2
Reduced organic anion transporter expression is a risk factor for hepatocellular carcinoma in chronic hepatitis C patients: a propensity score matching study. (24401597)
2014
3
Association of interleukin-8 gene polymorphisms with the risk of hepatocellular carcinoma. (24381110)
2014
4
Downregulation of microRNA-15b by hepatitis B virus X enhances hepatocellular carcinoma proliferation via fucosyltransferase 2-induced Globo H expression. (24122375)
2014
5
Diabetes mellitus is associated with hepatocellular carcinoma: a retrospective case-control study in hepatitis endemic area. (24386416)
2013
6
Collision tumors of hepatocellular carcinoma and malignant peritoneal mesothelioma. (23571781)
2013
7
Clinical implication of ZEB-1 and E-cadherin expression in hepatocellular carcinoma (HCC). (24304617)
2013
8
Silencing of DLGAP5 by siRNA Significantly Inhibits the Proliferation and Invasion of Hepatocellular Carcinoma Cells. (24324629)
2013
9
The expression and clinical significance of Omi/Htra2 in hepatocellular carcinoma. (23682386)
2013
10
The tumor-suppressive miR-497-195 cluster targets multiple cell-cycle regulators in hepatocellular carcinoma. (23544130)
2013
11
Study on the DNA repair gene XRCC1 and XRCC3 polymorphism in prediction and prognosis of hepatocellular carcinoma risk. (22456434)
2012
12
Heat shock protein 27 mediates the effect of 1,3,5-trihydroxy-13,13-dimethyl-2H-pyran [7,6-b] xanthone on mitochondrial apoptosis in hepatocellular carcinoma. (22677112)
2012
13
p53 codon 72 polymorphism is associated with susceptibility to hepatocellular carcinoma in the Turkish population: a case-control study. (21607615)
2012
14
A miR-1231 binding site polymorphism in the 3'UTR of IFNAR1 is associated with hepatocellular carcinoma susceptibility. (22824466)
2012
15
Autoimmune hepatitis, cirrhosis, and hepatocellular carcinoma (HCC). (21127980)
2011
16
CD1d gene is a target for a novel amplicon at 1q22-23.1 in human hepatocellular carcinoma. (19757161)
2010
17
Transthyretin-driven oncolytic adenovirus suppresses tumor growth in orthotopic and ascites models of hepatocellular carcinoma. (19134007)
2009
18
Milder liver cirrhosis and loss of serum HBeAg do not imply lower risk for hepatocellular carcinoma development in HBV-related cirrhosis. (19478697)
2009
19
Expression of galectin-3 involved in prognosis of patients with hepatocellular carcinoma. (18684128)
2008
20
Pilot clinical trial of localized concurrent chemoradiation therapy for locally advanced hepatocellular carcinoma with portal vein thrombosis. (18615601)
2008
21
Clinicopathological risk factors linked to recurrence pattern after curative hepatic resection for hepatocellular carcinoma--results of 152 resected cases. (18251164)
2007
22
AZD6244 and doxorubicin induce growth suppression and apoptosis in mouse models of hepatocellular carcinoma. (17876044)
2007
23
Expression of betacellulin and epidermal growth factor receptor in hepatocellular carcinoma: implications for angiogenesis. (16949929)
2006
24
Combined hepatocellular carcinoma and cholangiocarcinoma with components of mucinous carcinoma arising in a cirrhotic liver. (16634969)
2006
25
Interleukin-2 gene expression is a new biological prognostic marker in hepatocellular carcinomas. (15867481)
2005
26
Genes encoding Pir51, Beclin 1, RbAp48 and aldolase b are up or down-regulated in human primary hepatocellular carcinoma. (14966907)
2004
27
Cartilage oligomeric matrix protein expression in hepatocellular carcinoma and the cirrhotic liver. (14748877)
2004
28
Expression of WISPs and of their novel alternative variants in human hepatocellular carcinoma cells. (15650268)
2004
29
Complete disappearance with oral UFT administration of recurrent hepatocellular carcinoma of the remnant liver and multiple lung metastasis after hepatic resection]. (14518415)
2003
30
GSK-3beta phosphorylation and alteration of beta-catenin in hepatocellular carcinoma. (12969793)
2003
31
Expression of phosphatase and tensin homology deleted on chromosome ten(PTEN) and p53 protein and their significance in human hepatocellular carcinomas]. (12561434)
2003
32
Expression of angiogenic factors in hepatocellular carcinoma after transcatheter arterial chemoembolization. (14526434)
2003
33
Stable expression of antisense urokinase mRNA inhibits the proliferation and invasion of human hepatocellular carcinoma cells. (12536199)
2003
34
Reduced expression of insulin-like growth factor binding protein-3 and its promoter hypermethylation in human hepatocellular carcinoma. (11804742)
2002
35
RECK gene expression in hepatocellular carcinoma: correlation with invasion-related clinicopathological factors and its clinical significance. Reverse-inducing--cysteine-rich protein with Kazal motifs. (11124835)
2001
36
Biological impact of natural COOH-terminal deletions of hepatitis B virus X protein in hepatocellular carcinoma tissues. (11691796)
2001
37
Transforming growth factor beta1 and soluble Fas serum levels in hepatocellular carcinoma. (10843770)
2000
38
Fas and Fas ligand: strong co-expression in human hepatocytes surrounding hepatocellular carcinoma; can cancer induce suicide in peritumoural cells? (10861574)
2000
39
Small hyperechoic nodules in chronic liver diseases include hepatocellular carcinomas with low cyclin D1 and Ki-67 expression. (10347114)
1999
40
In situ detection of insulin-like growth factor II (IGF2) and H19 gene expression in hepatocellular carcinoma. (9609998)
1998
41
Homozygous deletions of the CDKN2 gene and loss of heterozygosity of 9p in primary hepatocellular carcinoma. (9464511)
1998
42
Lamellar fibrosis in the fibrolamellar variant of hepatocellular carcinoma: a role for transforming growth factor beta. (9249730)
1997
43
Target gene modulation in hepatocellular carcinomas by decreased DNA-binding of p53 mutations. (9096590)
1997
44
Comparative study of expression of p21 and c-myc protein in hepatocellular carcinoma with pericarcinomatous liver tissue]. (9868083)
1997
45
Nodular regenerative hyperplasia, dysplasia, and hepatocellular carcinoma. (8633567)
1996
46
Hepatocellular carcinoma arising in congenital hepatic fibrosis. (8122667)
1994
47
Cloning and increased expression of an insulin receptor substrate-1- like gene in human hepatocellular carcinoma. (1311924)
1992
48
HBV status and expression of ets-2, IGF-II, C-myc and N-ras in human hepatocellular carcinoma and adjacent nontumorous tissues--a comparative study]. (1653692)
1991
49
Immunohistochemical and ultrastructural localization of epidermal growth factor receptor in human liver and hepatocellular carcinoma tissues. (2156402)
1990
50
Pityriasis rotunda as a cutaneous marker of hepatocellular carcinoma: a comparison with its prevalence in other diseases. (2543437)
1989

Genetic Variations for Hepatocellular Carcinoma

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62UniProtKB/Swiss-Prot
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Genetic disease variations for Hepatocellular Carcinoma:

62 (show all 20)
id Symbol AA change Variation ID SNP ID
1AXIN1p.Leu106ArgVAR_015589
2AXIN1p.Pro345LeuVAR_015590
3AXIN1p.Gly425SerVAR_015591rs116350678
4AXIN1p.Gly650SerVAR_015592rs117208012
5CDKN3p.Trp31ArgVAR_013842
6CDKN3p.Phe78LeuVAR_013843
7CDKN3p.Cys79TyrVAR_013844
8CDKN3p.Asn91LysVAR_013845
9CDKN3p.Asp94ValVAR_013846
10CDKN3p.Leu95PheVAR_013847
11CDKN3p.Ile108ValVAR_013848rs144479038
12CDKN3p.Asn187SerVAR_013849
13CDKN3p.Lys195IleVAR_013850
14METp.Thr1173IleVAR_032490
15METp.Lys1244ArgVAR_032492
16METp.Met1250IleVAR_032493
17MTUS1p.Gln75LysVAR_035173rs61733703
18MTUS1p.Ala563SerVAR_035178
19MTUS1p.Asn873HisVAR_035180rs187103704
20MTUS1p.Gln1201ArgVAR_035184

Expression for genes affiliated with Hepatocellular Carcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hepatocellular Carcinoma

Search GEO for disease gene expression data for Hepatocellular Carcinoma.

Pathways for genes affiliated with Hepatocellular Carcinoma

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29KEGG, 12EMD Millipore, 51QIAGEN
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Pathways related to Hepatocellular Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.4MET, EGF, AXIN1, TP53
2
Hide members
11.2TP53, AXIN1, EGF
311.2TP53, AXIN1, EGF

Compounds for genes affiliated with Hepatocellular Carcinoma

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44Novoseek, 49PharmGKB, 11DrugBank, 59Tocris Bioscience
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Compounds related to Hepatocellular Carcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1actinomycin d4411.4TP53, CDKN3, EGF, MET
2gefitinib44 49 1113.3CDKN3, EGF, MET
3geldanamycin44 49 59 1114.2MET, EGF, TP53
4nocodazole44 1112.2TP53, CDKN3, EGF
5ly2940024411.1TP53, CDKN3, EGF, MET
6erbstatin4410.8EGF, CDKN3

GO Terms for genes affiliated with Hepatocellular Carcinoma

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16Gene Ontology
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Biological processes related to Hepatocellular Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of peptidyl-threonine phosphorylationGO:01080010.9AXIN1, EGF
2positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic processGO:200006010.6AXIN1, EGF

Products for genes affiliated with Hepatocellular Carcinoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hepatocellular Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet