HCC
MCID: HPT023
MIFTS: 79

Hepatocellular Carcinoma (HCC) malady

Genetic diseases, Rare diseases, Liver diseases, Cancer diseases, Gastrointestinal diseases categories

Summaries for Hepatocellular Carcinoma

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Sources:
9Disease Ontology, 35MedlinePlus, 66Wikipedia, 48OMIM, 34MalaCards
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MedlinePlus:35 Your liver is the largest organ inside your body. it helps your body digest food, store energy, and remove poisons. primary liver cancer starts in the liver. metastatic liver cancer starts somewhere else and spreads to your liver. risk factors for primary liver cancer include having hepatitis b or c heavy alcohol use having cirrhosis, or scarring of the liver having hemochromatosis, an iron storage disease obesity and diabetes symptoms can include a lump or pain on the right side of your abdomen and yellowing of the skin. however, you may not have symptoms until the cancer is advanced. this makes it harder to treat. doctors use tests that examine the liver and the blood to diagnose liver cancer. treatment options include surgery, radiation, chemotherapy, or liver transplantation. nih: national cancer institute

MalaCards: Hepatocellular Carcinoma, also known as liver cancer, is related to glioblastoma multiforme and thyroid cancer. An important gene associated with Hepatocellular Carcinoma is TP53 (tumor protein p53). The drugs mechlorethamine and irinotecan and the compound crcs have been mentioned in the context of this disorder. Affiliated tissues include the liver, liver and endothelial.

Disease Ontology:9 A gastrointestinal system cancer that is located in the liver.

Wikipedia:66 Hepatocellular carcinoma (HCC, also called malignant hepatoma) is the most common type of liver cancer.... more...

Description from OMIM:48 114550

Aliases & Classifications for Hepatocellular Carcinoma

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9Disease Ontology, 44NIH Rare Diseases, 23GTR, 48OMIM, 11DISEASES, 46Novoseek, 50Orphanet, 35MedlinePlus, 63UMLS, 41NCIt, 36MeSH, 59SNOMED-CT, 27ICD10 via Orphanet
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Classifications:



Aliases & Descriptions:

hepatocellular carcinoma 9 48 11 46
liver cancer 9 44 35
adult primary hepatocellular carcinoma 9 63
primary malignant neoplasm of liver 9 63
malignant hepato-biliary neoplasm 9 63
hepatocellular cancer 44 23
liver carcinoma 9 63
hepatic cancer 9 46
liver neoplasm 9 11
hepatoma 9 44
hcc 9 44
epithelial hepatic and intrahepatic bile duct neoplasm 9
malignant neoplasm of liver, not specified as primary 9
non-resectable primary hepatic malignant neoplasm 9
liver and intrahepatic biliary tract carcinoma 63
resectable malignant neoplasm of the liver 9
carcinoma of liver, specified as primary 9
primary malignant neoplasm of liver nos 9
malignant neoplasm of liver unspecified 9
resectable malignant neoplasm of liver 9
hepatocellular carcinoma of the mouse 63
malignant neoplasm of liver, primary 9
primary carcinoma of the liver cells 9
hepatocellular carcinoma, adult 44
adult hepatocellular carcinoma 50
adult primary liver carcinoma 9
malignant neoplasm of liver 9
primary carcinoma of liver 9
liver cell carcinoma adult 44
primary tumor of the liver 44
malignant tumor of liver 9
primary liver cancer 9
neoplasm metastasis 63
ca liver - primary 9
liver cancer adult 44
neoplasm of liver 9
hepatic neoplasm 9
liver neoplasms 63
hepatocarcinoma 44
adult hepatoma 9
secondary 9


Related Diseases for Hepatocellular Carcinoma

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Hepatocellular Carcinoma:



Diseases related to hepatocellular carcinoma

Symptoms for Hepatocellular Carcinoma

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48OMIM
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Clinical features from OMIM:

114550

Drugs & Therapeutics for Hepatocellular Carcinoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Genetic Tests for Hepatocellular Carcinoma

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23GTR
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Genetic tests related to Hepatocellular Carcinoma:

id Genetic test Affiliating Genes
1 Hepatocellular Carcinoma23

Anatomical Context for Hepatocellular Carcinoma

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34MalaCards, 15FMA
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MalaCards organs/tissues related to Hepatocellular Carcinoma:

34
Liver, Endothelial, T cells, Testes, Skin, Colon, Lung, Bone, Testis, Thyroid, Monocytes, Breast, Lymph node, B cells, Smooth muscle, Spleen, Prostate, Kidney, Myeloid, Fetal liver, Placenta, Pituitary, Bone marrow, Appendix, Brain, Skeletal muscle, Pancreas, Adrenal gland, Ovary

FMA organs/tissues related to Hepatocellular Carcinoma:

15
The liver

Animal Models for Hepatocellular Carcinoma or affiliated genes

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Publications for Hepatocellular Carcinoma

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53PubMed
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Articles related to Hepatocellular Carcinoma:

(show top 50)    (show all 6433)
idTitleAuthorsYear
1
Low expression of PAI-2 as a novel marker of portal vein tumor thrombosis and poor prognosis in hepatocellular carcinoma. (23188538)
2013
2
Modification of sialylation mediates the invasive properties and chemosensitivity of human hepatocellular carcinoma. (24255131)
2013
3
Complete pathological regression of hepatocellular carcinoma with portal vein thrombosis treated with sorafenib. (23914915)
2013
4
Combination of SLC administration and tregs depletion is an attractive strategy for targeting hepatocellular carcinoma. (24304581)
2013
5
Interobserver agreement of semi-automated and manual measurements of functional MRI metrics of treatment response in hepatocellular carcinoma. (24387824)
2013
6
Combining Locoregional Therapies in the Treatment of Hepatocellular Carcinoma. (24436520)
2013
7
Expression of FOXJ1 in hepatocellular carcinoma: correlation with patients' prognosis and tumor cell proliferation. (22488567)
2013
8
Clinical significance of therapy using branched-chain amino acid granules in patients with liver cirrhosis and hepatocellular carcinoma. (23819582)
2013
9
Effect of one-off complete tumor radiofrequency ablation on liver function and postoperative complication in small hepatocellular carcinoma. (24387942)
2013
10
Coronal reformatted CT images contribute to the precise evaluation of the radiofrequency ablative margin for hepatocellular carcinoma. (24346490)
2013
11
Notch1 activation contributes to tumor cell growth and proliferation in human hepatocellular carcinoma HepG2 and SMMC7721 cells. (22922832)
2012
12
Hepatocellular carcinoma as unusual cause for paraplegia. (22965954)
2012
13
Comparative analyses of regulatory T cell subsets in patients with hepatocellular carcinoma: a crucial role of CD25(-) FOXP3(-) T cells. (22419479)
2012
14
Metabonomic profiles discriminate hepatocellular carcinoma from liver cirrhosis by ultraperformance liquid chromatography-mass spectrometry. (22200553)
2012
15
Total and high molecular weight adiponectin and hepatocellular carcinoma with HCV infection. (22110596)
2011
16
Underexpressed microRNA-199b-5p targets hypoxia-inducible factor-1I+ in hepatocellular carcinoma and predicts prognosis of hepatocellular carcinoma patients. (21557766)
2011
17
Epidermal growth factor-containing fibulin-like extracellular matrix protein 1, EFEMP1, a novel tumor-suppressor gene detected in hepatocellular carcinoma using double combination array analysis. (19898900)
2010
18
Hepatocellular carcinoma and regenerating nodule in a 3-year-old child with Alagille syndrome. (20714715)
2010
19
Expression of I+-taxilin in hepatocellular carcinoma correlates with growth activity and malignant potential of the tumor. (21042709)
2010
20
Expression characteristics of nuclear factor kappa B in hepatocellular carcinoma tissues]. (19958645)
2009
21
Role of serum prothrombin induced by vitamin K absence or antagonist-II in the early detection of hepatocellular carcinoma in patients with chronic hepatitis B virus infection. (19391065)
2009
22
Expression of KiSS-1 gene and its role in invasion and metastasis of human hepatocellular carcinoma. (19645016)
2009
23
Expression of STK15 mRNA in hepatocellular carcinoma and its prognostic significance. (19232520)
2009
24
Association analysis between the Cdc6 G1321A polymorphism and the risk for non-Hodgkin lymphoma and hepatocellular carcinoma. (19101572)
2009
25
Expression of p53 protein in liver and sera of patients with liver fibrosis, liver cirrhosis or hepatocellular carcinoma associated with chronic HCV infection. (19063876)
2009
26
Glycomic analysis of alpha-fetoprotein L3 in hepatoma cell lines and hepatocellular carcinoma patients. (18479159)
2008
27
Epigenetic instability is rare in fibrolamellar carcinomas but common in viral-associated hepatocellular carcinomas. (18264082)
2008
28
Inhibitory effect of RNAi targeting human telomerase reverse transcriptase against human hepatocellular carcinoma cells]. (18753050)
2008
29
No association exists between E-cadherin gene polymorphism and tumor recurrence in patients with hepatocellular carcinoma after transplantation. (17548247)
2007
30
UDP-glucuronosyltransferase UGT1A7 genetic polymorphisms in hepatocellular carcinoma: a differential impact according to seropositivity of HBV or HCV markers? (18021430)
2007
31
Novel identification of zyxin upregulations in the motile phenotype of hepatocellular carcinoma. (16680155)
2006
32
Role of immunosuppression and tumor differentiation in predicting recurrence after liver transplantation for hepatocellular carcinoma: a multicenter study of 412 patients. (17143948)
2006
33
Expression of epithelial cellular adhesion molecule (Ep-CAM) in chronic (necro-)inflammatory liver diseases and hepatocellular carcinoma. (16364680)
2006
34
UDP-glucuronosyltransferase 1A7 genetic polymorphisms are associated with hepatocellular carcinoma risk and onset age. (16086712)
2005
35
Acyclic retinoid in the chemoprevention of hepatocellular carcinoma (review). (15010815)
2004
36
High levels of p53 protein expression do not correlate with p53 mutations in hepatocellular carcinoma. (15500550)
2004
37
CD44 and VEGF expression in extrahepatic metastasis of human hepatocellular carcinoma. (15239258)
2004
38
Factors related to acute upper gastrointestinal bleeding after transcatheter arterial chemoembolization in patients with hepatocellular carcinoma]. (12478898)
2002
39
Enzymatic activity of cathepsin B, cathepsin B and L, plasmin, trypsin and collagenase in hepatocellular carcinoma]. (12412410)
2002
40
Subacute cutaneous lupus erythematosus associated with hepatocellular carcinoma. (11309033)
2001
41
Effects of vascular endothelial growth factor on adhesion molecular expression of hepatocellular carcinoma HepG]. (11509135)
2001
42
Lack of frameshift mutations at coding mononucleotide repeats in hepatocellular carcinoma in Japanese patients. (10699890)
2000
43
Circulating intercellular adhesion molecule-1 in chronic liver disease and hepatocellular carcinoma. (10462824)
1999
44
Retrovirus-mediated gene therapy for hepatocellular carcinoma: selective and enhanced suicide gene expression regulated by human alpha-fetoprotein enhancer directly linked to its promoter. (9824049)
1998
45
Up-regulation of peripheral benzodiazepine receptor system in hepatocellular carcinoma. (9771915)
1998
46
Detection of a unique gamma-glutamyl transpeptidase messenger RNA species closely related to the development of hepatocellular carcinoma in humans: a new candidate for early diagnosis of hepatocellular carcinoma. (8621139)
1996
47
Hepatocellular carcinoma associated with alcoholic liver disease: a clinicopathological study and genetic polymorphism of aldehyde dehydrogenase 2. (8986242)
1996
48
Comparison of clinico-pathological features in hepatitis B virus-associated hepatocellular carcinoma with or without hepatitis D virus superinfection. (8912142)
1996
49
p53 mutations and aflatoxin B1 exposure in hepatocellular carcinoma patients from Thailand. (8380058)
1993
50
Late recurrence of a hepatocellular carcinoma in a patient with incomplete Alagille syndrome. (2170223)
1990

Variations for Hepatocellular Carcinoma

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Sources:
65UniProtKB/Swiss-Prot, 1 National Center for Biotechnology Information (Clinvar), 8dbSNP
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UniProtKB/Swiss-Prot genetic disease variations for Hepatocellular Carcinoma:

65 (show all 20)
id Symbol AA change Variation ID SNP ID
1AXIN1p.Leu106ArgVAR_015589
2AXIN1p.Pro345LeuVAR_015590
3AXIN1p.Gly425SerVAR_015591rs116350678
4AXIN1p.Gly650SerVAR_015592rs117208012
5CDKN3p.Trp31ArgVAR_013842
6CDKN3p.Phe78LeuVAR_013843
7CDKN3p.Cys79TyrVAR_013844
8CDKN3p.Asn91LysVAR_013845
9CDKN3p.Asp94ValVAR_013846
10CDKN3p.Leu95PheVAR_013847
11CDKN3p.Ile108ValVAR_013848rs144479038
12CDKN3p.Asn187SerVAR_013849
13CDKN3p.Lys195IleVAR_013850
14METp.Thr1173IleVAR_032490
15METp.Lys1244ArgVAR_032492
16METp.Met1250IleVAR_032493
17MTUS1p.Gln75LysVAR_035173rs61733703
18MTUS1p.Ala563SerVAR_035178
19MTUS1p.Asn873HisVAR_035180rs187103704
20MTUS1p.Gln1201ArgVAR_035184

Clinvar genetic disease variations for Hepatocellular Carcinoma:

1 (show all 13)
id Gene Name Type Significance SNP ID Assembly Location
1TP53NM_000546.5(TP53): c.747G> T (p.Arg249Ser)single nucleotide variantPathogenicrs28934571GRCh37Chr 17, 7577534: 7577534
2TP53NM_000546.5(TP53): c.469G> T (p.Val157Phe)single nucleotide variantPathogenicrs121912654GRCh37Chr 17, 7578461: 7578461
3PIK3CANM_006218.2(PIK3CA): c.3140A> G (p.His1047Arg)single nucleotide variantPathogenicrs121913279GRCh37Chr 3, 178952085: 178952085
4PIK3CANM_006218.2(PIK3CA): c.3203dupA (p.Asn1068Lysfs)duplicationPathogenicGRCh37Chr 3, 178952148: 178952148
5PIK3CANM_006218.2(PIK3CA): c.1634A> C (p.Glu545Ala)single nucleotide variantPathogenicrs121913274GRCh37Chr 3, 178936092: 178936092
6IGF2RNM_000876.2(IGF2R): c.4346G> T (p.Gly1449Val)single nucleotide variantPathogenicrs121434587GRCh37Chr 6, 160490993: 160490993
7IGF2RNM_000876.2(IGF2R): c.4391G> A (p.Gly1464Glu)single nucleotide variantPathogenicrs121434588GRCh37Chr 6, 160491038: 160491038
8CTNNB1NM_001904.3(CTNNB1): c.134C> T (p.Ser45Phe)single nucleotide variantPathogenicrs121913409GRCh37Chr 3, 41266137: 41266137
9CTNNB1NM_001904.3(CTNNB1): c.133T> C (p.Ser45Pro)single nucleotide variantLikely pathogenic, Pathogenicrs121913407GRCh37Chr 3, 41266136: 41266136
10PDGFRLPDGRL, 2-BP DELdeletionPathogenic
11AXIN1NM_003502.3(AXIN1): c.1085_1116del32 (p.Val362Alafs)deletionPathogenicGRCh38Chr 16, 309973: 310004
12CASP8NM_001228.4(CASP8): c.1279_1280delGT (p.Val427Phefs)deletionPathogenicGRCh37Chr 2, 202149964: 202149965
13APCNM_000038.5(APC): c.1695delA (p.Val566Leufs)deletionPathogenicrs397514032GRCh37Chr 5, 112164621: 112164621

Expression for genes affiliated with Hepatocellular Carcinoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hepatocellular Carcinoma

Search GEO for disease gene expression data for Hepatocellular Carcinoma.

Pathways for genes affiliated with Hepatocellular Carcinoma

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Compounds for genes affiliated with Hepatocellular Carcinoma

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46Novoseek
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Compounds related to Hepatocellular Carcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1crcs4610.5MET, TP53

GO Terms for genes affiliated with Hepatocellular Carcinoma

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17Gene Ontology
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Cellular components related to Hepatocellular Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563410.6AXIN1, VPS37A, TP53, C9orf78, YY1AP1, CHP2

Products for genes affiliated with Hepatocellular Carcinoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hepatocellular Carcinoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet