MCID: HPT068
MIFTS: 23

Hepatocellular Carcinoma, Childhood-Onset malady

Genetic diseases, Liver diseases, Cancer diseases, Rare diseases categories
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Summaries for Hepatocellular Carcinoma, Childhood-Onset

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MalaCards based summary: Hepatocellular Carcinoma, Childhood-Onset is related to thyroid cancer, anaplastic and synovial sarcoma. An important gene associated with Hepatocellular Carcinoma, Childhood-Onset is CTNNB1 (catenin (cadherin-associated protein), beta 1, 88kDa), and among its related pathways are Pathways in cancer and Ras signaling pathway. The compounds crcs and ag 1478 have been mentioned in the context of this disorder. Affiliated tissues include liver, and related mouse phenotype limbs/digits/tail.

Aliases & Classifications for Hepatocellular Carcinoma, Childhood-Onset

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Sources:
48Orphanet, 26ICD10 via Orphanet
See all sources

Hepatocellular Carcinoma, Childhood-Onset, Aliases & Descriptions:

Name: Hepatocellular Carcinoma, Childhood-Onset 48


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Cancer diseases, Rare diseases
Anatomical: Liver diseases


Characteristics (Orphanet epidemiological data):

48
hepatocellular carcinoma, childhood-onset:
Inheritance: Sporadic; Age of onset: Childhood


External Ids:

ICD10 via Orphanet26 C22.0

Related Diseases for Hepatocellular Carcinoma, Childhood-Onset

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Diseases in the Hepatocellular Carcinoma, Childhood family:

hepatocellular carcinoma, childhood-onset

Diseases related to Hepatocellular Carcinoma, Childhood-Onset via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 18)
idRelated DiseaseScoreTop Affiliating Genes
1thyroid cancer, anaplastic10.0CTNNB1, MET
2synovial sarcoma10.0CTNNB1, MET
3hepatoblastoma10.0CTNNB1, MET
4papillary thyroid carcinoma10.0CTNNB1, MET
5gastric adenocarcinoma10.0MET, CTNNB1
6lung adenocarcinoma10.0CTNNB1, MET
7prostate cancer10.0MET, CTNNB1
8non-small cell lung carcinoma10.0MET, CTNNB1
9pancreatic cancer10.0CTNNB1, MET
10adenoma10.0CTNNB1, MET
11stomach cancer10.0MET, CTNNB1
12breast cancer9.9CTNNB1, MET
13ovarian cancer9.9CTNNB1, MET
14colonic benign neoplasm9.9CTNNB1, MET
15liver cancer9.9MET, CTNNB1
16adenocarcinoma9.9CTNNB1, MET
17colorectal cancer9.8CTNNB1, MET
18tongue squamous cell carcinoma9.8CTNNB1, MET

Graphical network of diseases related to Hepatocellular Carcinoma, Childhood-Onset:



Diseases related to hepatocellular carcinoma, childhood-onset

Symptoms for Hepatocellular Carcinoma, Childhood-Onset

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Drugs & Therapeutics for Hepatocellular Carcinoma, Childhood-Onset

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Drug clinical trials:

Search ClinicalTrials for Hepatocellular Carcinoma, Childhood-Onset

Search NIH Clinical Center for Hepatocellular Carcinoma, Childhood-Onset

Genetic Tests for Hepatocellular Carcinoma, Childhood-Onset

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Anatomical Context for Hepatocellular Carcinoma, Childhood-Onset

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MalaCards organs/tissues related to Hepatocellular Carcinoma, Childhood-Onset:

32
Liver

Animal Models for Hepatocellular Carcinoma, Childhood-Onset or affiliated genes

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MGI Mouse Phenotypes related to Hepatocellular Carcinoma, Childhood-Onset:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053719.1CTNNB1, MET

Publications for Hepatocellular Carcinoma, Childhood-Onset

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Variations for Hepatocellular Carcinoma, Childhood-Onset

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Expression for genes affiliated with Hepatocellular Carcinoma, Childhood-Onset

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Expression patterns in normal tissues for genes affiliated with Hepatocellular Carcinoma, Childhood-Onset

Search GEO for disease gene expression data for Hepatocellular Carcinoma, Childhood-Onset.

Pathways for genes affiliated with Hepatocellular Carcinoma, Childhood-Onset

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Pathways related to Hepatocellular Carcinoma, Childhood-Onset according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1MET, CTNNB1
2
Show member pathways
9.1CTNNB1, MET
3
Show member pathways
9.1CTNNB1, MET
4
Show member pathways
9.1CTNNB1, MET
5
Show member pathways
9.1CTNNB1, MET
6
Show member pathways
9.1CTNNB1, MET
7
Show member pathways
9.1CTNNB1, MET
8
Show member pathways
Integrin-mediated cell adhesion37
Focal Adhesion37
9.1CTNNB1, MET
99.1MET, CTNNB1
109.1CTNNB1, MET
119.1CTNNB1, MET
129.1CTNNB1, MET
139.1MET, CTNNB1
149.1CTNNB1, MET
15
Show member pathways
Signaling Pathways in Glioblastoma37
9.1CTNNB1, MET
16
Show member pathways
9.1CTNNB1, MET
179.1CTNNB1, MET

Compounds for genes affiliated with Hepatocellular Carcinoma, Childhood-Onset

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Compounds related to Hepatocellular Carcinoma, Childhood-Onset according to GeneCards/GeneDecks:

(show all 34)
idCompoundScoreTop Affiliating Genes
1crcs449.5CTNNB1, MET
2ag 1478449.5CTNNB1, MET
3gefitinib44 50 1111.5CTNNB1, MET
4geldanamycin44 50 61 1112.5CTNNB1, MET
5p002449.5MET, CTNNB1
6adriamycin449.5CTNNB1, MET
7inositol449.5CTNNB1, MET
8herbimycin a44 6110.5CTNNB1, MET
9agar449.5MET, CTNNB1
10matrigel449.5CTNNB1, MET
11phosphotyrosine449.5CTNNB1, MET
12vitamin d449.5MET, CTNNB1
13rapamycin449.5CTNNB1, MET
14pd 98,059449.5MET, CTNNB1
15ly294002449.5CTNNB1, MET
16wortmannin449.5CTNNB1, MET
17doxorubicin44 50 1111.5CTNNB1, MET
18glycogen44 2410.4MET, CTNNB1
19phosphoinositide449.4CTNNB1, MET
20paraffin449.4CTNNB1, MET
21genistein44 28 61 2 24 1114.4CTNNB1, MET
22pge2449.4MET, CTNNB1
23thymidine44 2410.4CTNNB1, MET
24cisplatin44 50 61 1112.4CTNNB1, MET
25cycloheximide449.4CTNNB1, MET
26progesterone44 28 61 24 1113.3MET, CTNNB1
27testosterone44 61 24 1112.3CTNNB1, MET
28steroid449.3CTNNB1, MET
29oligonucleotide449.2CTNNB1, MET
30vegf449.2MET, CTNNB1
31arginine449.1CTNNB1, MET
32alanine449.1CTNNB1, MET
33phosphatidylinositol449.0CTNNB1, MET
34threonine448.8CTNNB1, MET

GO Terms for genes affiliated with Hepatocellular Carcinoma, Childhood-Onset

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Biological processes related to Hepatocellular Carcinoma, Childhood-Onset according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of transcription from RNA polymerase II promoterGO:0459449.1CTNNB1, MET
2liver developmentGO:0018898.8CTNNB1, MET

Molecular functions related to Hepatocellular Carcinoma, Childhood-Onset according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein phosphatase bindingGO:0199039.1CTNNB1, MET

Products for genes affiliated with Hepatocellular Carcinoma, Childhood-Onset

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  • Antibodies
  • Proteins
  • Lysates

Sources for Hepatocellular Carcinoma, Childhood-Onset

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet